LOCUS       NP_001429756             261 aa            linear   VRT 27-AUG-2025
DEFINITION  scavenger receptor cysteine-rich type 1 protein M130 [Danio rerio].
ACCESSION   NP_001429756
VERSION     NP_001429756.1
DBSOURCE    REFSEQ: accession NM_001442827.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..261
                     /product="scavenger receptor cysteine-rich type 1 protein
                     M130"
                     /calculated_mol_wt=28677
     CDS             1..261
                     /gene="LOC101886073"
                     /coded_by="NM_001442827.1:60..845"
                     /db_xref="GeneID:101886073"
ORIGIN      
        1 mlrplldfif amvlndylft gaenirlvng ldvcfgtvev knsnsqwetv cddswdinna
       61 avvcselgcg raiialgqai fgegtgnvsw ikfrcignet sfkscssrna tsvcshseda
      121 gvvcaassvv yiaaaviivl fisssllivl lvkkrkkmkt iqicsssida vnmpavlhne
      181 rneetidddy evvdmdpgvr edsdseqdyv nidqgdsdpd yvnvetdese qdyvnmetdd
      241 seqdyinaai teniiydrql q
//
LOCUS       NP_001429755            1016 aa            linear   VRT 27-AUG-2025
DEFINITION  scavenger receptor cysteine-rich domain-containing protein DMBT1
            precursor [Danio rerio].
ACCESSION   NP_001429755
VERSION     NP_001429755.1
DBSOURCE    REFSEQ: accession NM_001442826.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1016)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588721.510723.1,
                                           SRR32588727.536342.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505372,
                                           SAMEA3505373 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..1016
                     /product="scavenger receptor cysteine-rich
                     domain-containing protein DMBT1 precursor"
                     /calculated_mol_wt=105292
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3715
     CDS             1..1016
                     /gene="LOC560447"
                     /coded_by="NM_001442826.1:85..3135"
                     /db_xref="GeneID:560447"
ORIGIN      
        1 mhiptflhnt ritmarfsll twilasalts itgyslrlin gnndcsgrve ilyngvwgtv
       61 cdddwdmnda avvcrqmgcg gavsapqsas fgqgrgriwl ddvrcsgses sltdcshrgf
      121 gehncghsed agvvclvsdv rlvggfhscs grveiqyngv wgtvcddswd mndaavvcrq
      181 mgcggavsas qsasfgqgsg piwlddvgcs gsessliqcs rkgfgehncg hsedagvvct
      241 qdngklsdir lvdgfdsccg rveihhsgqw gsvcddnwdm ndaavvcrql qcgsaisaph
      301 saafgpgsgs iwldevqctg segtliqcsh dglgkhncnh gedtgvvcss elqmaslali
      361 sthsvvspge ivqfrcstpk prcsanaefq lfingsslss qthvsnvtfs invdvshqge
      421 yscqysyqnn tvksplsntv titvvhlpqp sispsapdgg fffistasal tsvtarfslr
      481 lvngnndcsg rveilynsvw gtvcgdywdm ndaavvcrqm gcggavsapq sasfgqgsgq
      541 iwmddvgcsg sessltdcsh rgfgehdcgh hedagvvctq gklpsirlad gfdsccgrve
      601 ilqygewgsv cddnwdmnda avvcrqlqcg saisaphsaa fgpgsgsiwl devqctgseg
      661 tliqcshdgl grhncnhged agvvcsselq maslalisth savspgeivq frcstpkprc
      721 sanaefqlfi ngsllssqkh vssvtfslnv dvshqgeysc qysyqnntvk sslsntvtit
      781 vvhlqqpsis psapdggfvv gpqgpviprg hrftitcstk sqfpggsfyl fresnihriq
      841 rsvsistsfs fpeaeysdeg iyscvyevrv ssrsfrsyas elllititas llpavigaal
      901 sagllllail iivmflkrrq kkkkndeahl kcsfrkgaan tyasssadnn ykeddedddy
      961 yenvelkfkn ldhddyeedy mkvdvgseed yvnaditknk cvadksdeni yesycd
//
LOCUS       NP_001429759            1448 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 1 [Danio rerio].
ACCESSION   NP_001429759 XP_073781297
VERSION     NP_001429759.1
DBSOURCE    REFSEQ: accession NM_001442830.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1448)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            On Aug 27, 2025 this sequence version replaced XP_073781297.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588727.522584.1,
                                           SRR32588725.431787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1448
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     1"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=162347
     CDS             1..1448
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442830.1:190..4536"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh dgyidelgdg ytehvnpale hpqlsdlpqk
     1261 mtfdsqpkph sdgnmpritl nkarvysdln dstdrtglrs dfpdvtfdlg vnywddfddr
     1321 nlvdasnvcc esqqfnpmie hhqpahsgls sglshcpaqt lqetvspvlp qrvqpmavtp
     1381 qtamwtnlnt ntlssdqsqa skgsvqkrfd ffsrtdaalk entpvgsdht keisdeahvf
     1441 fgmfdglf
//
LOCUS       NP_001429762            1433 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 2 [Danio rerio].
ACCESSION   NP_001429762
VERSION     NP_001429762.1
DBSOURCE    REFSEQ: accession NM_001442833.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1433)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.10754481.1,
                                           SRR32588727.2637627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1433
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     2"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=160611
     CDS             1..1433
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442833.1:190..4491"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh degeqsslgl egheemtfds qpkphsdgnm
     1261 pritlnkarv ysdlndstdr tglrsdfpdv tfdlgvnywd dfddrnlvda snvccesqqf
     1321 npmiehhqpa hsglssglsh cpaqtlqetv spvlpqrvqp mavtpqtamw tnlntntlss
     1381 dqsqaskgsv qkrfdffsrt daalkentpv gsdhtkeisd eahvffgmfd glf
//
LOCUS       NP_001429775             265 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized LOC137490038 [Danio rerio].
ACCESSION   NP_001429775
VERSION     NP_001429775.1
DBSOURCE    REFSEQ: accession NM_001442846.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA3505381, SAMEA3505382
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..265
                     /product="uncharacterized LOC137490038"
                     /calculated_mol_wt=30242
     CDS             1..265
                     /gene="LOC137490038"
                     /coded_by="NM_001442846.1:126..923"
                     /db_xref="GeneID:137490038"
ORIGIN      
        1 msdpepcrik hedteqqidq ieenteikee ehhvkvedkn hlqtddikrk knsfictecg
       61 ksfsqlyhvn rhmkihtgek pftctqcgks fsqssdlndh mkthtgekpf tctqcgksfs
      121 qsahlnlhmr ihtgekpftc tqcgrsfiql phlnkhmlsh tgekpytctq cgrsfssssn
      181 lnvhmrihtg erpftctqce ksfsqlshln ghlrihtgek pftctqcgks fsqishlnrh
      241 mmshtgerpy tctqkmssss snlnt
//
LOCUS       NP_001352115            2435 aa            linear   VRT 27-AUG-2025
DEFINITION  CREB binding protein b [Danio rerio].
ACCESSION   NP_001352115 XP_009297440 XP_021328554
VERSION     NP_001352115.2
DBSOURCE    REFSEQ: accession NM_001365186.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 2435)
  AUTHORS   Duan,W., Huang,G., Sui,Y., Wang,K., Yu,Y., Chu,X., Cao,X., Chen,L.,
            Liu,J., Eichler,E.E. and Xiong,B.
  TITLE     Deficiency of DDX3X results in neurogenesis defects and abnormal
            behaviors via dysfunction of the Notch signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (45), e2404173121 (2024)
   PUBMED   39471229
REFERENCE   2  (residues 1 to 2435)
  AUTHORS   Zhou,W.H., Luo,Y., Li,R.X., Degrace,P., Jourdan,T., Qiao,F.,
            Chen,L.Q., Zhang,M.L. and Du,Z.Y.
  TITLE     Inhibition of mitochondrial fatty acid beta-oxidation activates
            mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation
            of Raptor in zebrafish
  JOURNAL   J Biol Chem 299 (10), 105220 (2023)
   PUBMED   37660921
REFERENCE   3  (residues 1 to 2435)
  AUTHORS   Kumari,S., Sharma,P., Mazumder,A.G., Rana,A.K., Sharma,S. and
            Singh,D.
  TITLE     Development and validation of chemical kindling in adult zebrafish:
            A simple and improved chronic model for screening of antiepileptic
            agents
  JOURNAL   J Neurosci Methods 346, 108916 (2020)
   PUBMED   32818549
REFERENCE   4  (residues 1 to 2435)
  AUTHORS   Fellous,A., Earley,R.L. and Silvestre,F.
  TITLE     Identification and expression of mangrove rivulus (Kryptolebias
            marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase
            (KAT) genes
  JOURNAL   Gene 691, 56-69 (2019)
   PUBMED   30615915
REFERENCE   5  (residues 1 to 2435)
  AUTHORS   Zhang,B., Wu,X., Zhang,W., Shen,W., Sun,Q., Liu,K., Zhang,Y.,
            Wang,Q., Li,Y., Meng,A. and Xie,W.
  TITLE     Widespread Enhancer Dememorization and Promoter Priming during
            Parental-to-Zygotic Transition
  JOURNAL   Mol Cell 72 (4), 673-686 (2018)
   PUBMED   30444999
REFERENCE   6  (residues 1 to 2435)
  AUTHORS   Batut,J., Duboe,C. and Vandel,L.
  TITLE     Expression patterns of CREB binding protein (CREBBP) and its
            methylated species during zebrafish development
  JOURNAL   Int J Dev Biol 59 (4-6), 229-234 (2015)
   PUBMED   26260685
  REMARK    GeneRIF: Data suggest that methylation may regulate coactivator
            cAMP-response element-binding protein (CREB) binding protein
            (CREBBP) import to the nucleus during development and could
            therefore participate in the control of early developmental
            processes.
REFERENCE   7  (residues 1 to 2435)
  AUTHORS   Huang,H.T., Kathrein,K.L., Barton,A., Gitlin,Z., Huang,Y.H.,
            Ward,T.P., Hofmann,O., Dibiase,A., Song,A., Tyekucheva,S., Hide,W.,
            Zhou,Y. and Zon,L.I.
  TITLE     A network of epigenetic regulators guides developmental
            haematopoiesis in vivo
  JOURNAL   Nat Cell Biol 15 (12), 1516-1525 (2013)
   PUBMED   24240475
REFERENCE   8  (residues 1 to 2435)
  AUTHORS   Pei,D.S., Yang,X.J., Liu,W., Guikema,J.E., Schrader,C.E. and
            Strauss,P.R.
  TITLE     A novel regulatory circuit in base excision repair involving AP
            endonuclease 1, Creb1 and DNA polymerase beta
  JOURNAL   Nucleic Acids Res 39 (8), 3156-3165 (2011)
   PUBMED   21172930
REFERENCE   9  (residues 1 to 2435)
  AUTHORS   Sato,Y., Hashiguchi,Y. and Nishida,M.
  TITLE     Temporal pattern of loss/persistence of duplicate genes involved in
            signal transduction and metabolic pathways after teleost-specific
            genome duplication
  JOURNAL   BMC Evol Biol 9, 127 (2009)
   PUBMED   19500364
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 2435)
  AUTHORS   Bertrand,S., Thisse,B., Tavares,R., Sachs,L., Chaumot,A.,
            Bardet,P.L., Escriva,H., Duffraisse,M., Marchand,O., Safi,R.,
            Thisse,C. and Laudet,V.
  TITLE     Unexpected novel relational links uncovered by extensive
            developmental profiling of nuclear receptor expression
  JOURNAL   PLoS Genet 3 (11), e188 (2007)
   PUBMED   17997606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            On Aug 27, 2025 this sequence version replaced NP_001352115.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01007260.1,
                                           SRR26395012.1056391.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505371,
                                           SAMEA3505372 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..2435
                     /product="CREB binding protein b"
                     /EC_number="2.3.1.48"
                     /note="CREBBPa"
                     /calculated_mol_wt=267704
     CDS             1..2435
                     /gene="crebbpb"
                     /gene_synonym="CBP-A; crebbp; gb:dq017638; im:7150488;
                     si:ch211-121i18.1; wu:fp53a03; Zfcbp"
                     /coded_by="NM_001365186.2:737..8044"
                     /db_xref="GeneID:567111"
                     /db_xref="ZFIN:ZDB-GENE-050302-102"
ORIGIN      
        1 madnlldmgp saakrpklns palsssdtpd fvslfdlend lpdelipngd lglmsmpsng
       61 dggvgsrmgg nvpdaaakhk qlsqllqags gsglggnlsp qsgmggqlga lgkspmgqgs
      121 pghqtqapkp vgtptgqgnn spgmgmntgf npamlnnnnq ahglmgqnmt pqgqmmngvm
      181 gpagrgrtap gmqyqgqgmq gapvgagggq gvgvsgsvla etltqgapqm gahnalnqqa
      241 gnmnkmglat angpfgqqyv qgsvqqmsna glnaqmqnka alpnslqptl kgassvpnll
      301 qqqvpsvgmv pgqgvsagpt adpekrkliq qqlvlllhah kcqrreqang evracalphc
      361 rtmknvlnhm thcqagkscq vahcassrqi ishwknctrh dcpvclplkn asdkrnqqpm
      421 lsspnpgmqs plgqvgtsqp aapaissgth idpssmqray aalglpygnq paaqtqvagq
      481 qptqtqqmrs maalgsnqmn iggngmadqt nlhtdsslps slssnqmmpd gsnmggagnl
      541 ptaaplsmpg mkkpwhehvt qdlrnhlvhk lvqaifptpd paalkdrrme nlvayarkve
      601 gdmyesansr deyyhflaek iykiqkelee krksrlskpq mgaqgpqqpg lpqpnpmgpa
      661 qairppngpv smsnvpnqlm armqvpqgmg qfnpvtmqnv qmsqsqvgap raaspmthnp
      721 qmgmgnvppm vmspsrmpqa qammgghann mvgqtpnqnq fmnqtpfpas aggmnvnvnl
      781 aqqsgqtvqq qqqqnanltl navgslgpps alcstpppps astpsaaasl qslqtqpstp
      841 asvgghvtpt hipsglprpp svlgsspaps qphtplqsqp eppmqmqqpt svqaqqpstp
      901 lsqmapsvdn rvptpasvae thsqqalpdy paaepkiehq edeqevesgk krpdikmede
      961 dvkppqvkeq petvepkqep metedkkpet ktepkeeevs stnsstpanq saqsrkkifk
     1021 peelrqalmp tlealyrqdp eslpfrqpvd pnllgipdyf divknpidls tikrkldtgq
     1081 yqepwqyvdd iwlmfnnawl ynrktsrvyk ycsklaevfe qeidpvmqgl gyccgrkyef
     1141 spqtlccygk qlctisrdgt yysyqnryhf cekcfneiqg dsvtlgddpt qsqtyvssaa
     1201 qkslsmiske qfekkkndtl dsepfveckd cgrkmhqicv lhydviwpsg ficdnclkks
     1261 gksrkenkfs akklqctrlg syiedrvnky lkrqnhpeag evfvrvvass dktvevkpgm
     1321 ksrfvdsgem sesfpyrtka lfafeeidgv dvcffgmhvq eygsdcpfpn trrvyisyld
     1381 sihffkprll rtavyheili gyleyvkklg yvtghiwacp psegddyifh chppdqkipk
     1441 pkrlqewyrk mldkafaeri ihdykdifkq atedrltsay elpyfegdfw pnvleesike
     1501 leqeeeerkk eentassett egaqadskna kkknnkktnk nkssvsrank kkpgmpnvan
     1561 dlsqklyatm ekhkevffvi hlhagpvvnt lppimdpdpl ltcdlmdgrd afltlardkh
     1621 wefsslrrck wstmcmlvel hnqgqdrfvy tcneckhhve trwhctvced fdlcincyns
     1681 kghehqmvkw glgldddsnn qggeankspq esrrlsiqrc iqslvhacqc rnancslpsc
     1741 qkmkrvvqht kgckrktngg cpvckqlial ccyhakhcqe nkcpvpfcln ikhklrqqqi
     1801 qqrlqqaqmm rrrmalmqgr gmppslpspt tsggpgtpns qqlqqpntpq tsqalanqpq
     1861 qthpnvaamv qafpnqpptp gsqgkpgpqs splpqqqspl pippqqqpqp spqqqalkva
     1921 kqiemmtkvk qqqqqqqqqq qqqqqqqqqq qqqqqqqdyr msmngmpmnq prmmtsmqmm
     1981 gprgpqmvqn mqqgqwapgm amqnpqgppp qqvpqqqmam aqqqsqvaqt pqqaqmiqra
     2041 lmqqqqqqqq qprqiqavmp pqqvqpqapq qqgmqqrgvt snitpgalqd llrtlkspss
     2101 pqqqqqvlni lksnphlmaa fikqrtakyq anqpqqqqnp qamlasqqgm qnmaamqpgs
     2161 vqrpvmppqq qpqpqpaatq amaalgsqgq mmnaahngnq qlfrrqllrq mqqqqqhqqq
     2221 qgamppgqgr fpqpqgaasy sqirvqqqma mqggagpmgq mppmaqmgqp gmgldaqqqq
     2281 nlmqqrmlqq qqqqqqqmmk qqmgspaqaa smspqphmlg gqpqgahmpg qamanalgnq
     2341 vrspapvqsp rppsqqpphs spsprmqpqp splhpgsshp slagpmpgpm dqahmctaeq
     2401 samlpqlntp nrggltndln mdttgdtlek fvegl
//
LOCUS       NP_001429763            1433 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 2 [Danio rerio].
ACCESSION   NP_001429763
VERSION     NP_001429763.1
DBSOURCE    REFSEQ: accession NM_001442834.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1433)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.27250832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1433
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     2"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=160611
     CDS             1..1433
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442834.1:68..4369"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh degeqsslgl egheemtfds qpkphsdgnm
     1261 pritlnkarv ysdlndstdr tglrsdfpdv tfdlgvnywd dfddrnlvda snvccesqqf
     1321 npmiehhqpa hsglssglsh cpaqtlqetv spvlpqrvqp mavtpqtamw tnlntntlss
     1381 dqsqaskgsv qkrfdffsrt daalkentpv gsdhtkeisd eahvffgmfd glf
//
LOCUS       NP_001429764            1509 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 3 [Danio rerio].
ACCESSION   NP_001429764 XP_021322847
VERSION     NP_001429764.1
DBSOURCE    REFSEQ: accession NM_001442835.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1509)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            On Aug 27, 2025 this sequence version replaced XP_021322847.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588732.10739522.1,
                                           SRR32588722.13467350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1509
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1509
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     3"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=168514
     CDS             1..1509
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442835.1:190..4719"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh dgyidelgdg ytehvnpale hpqlsdlpqk
     1261 geqsslgleg heemtfdsqp kphsdgnmpr itlnkarvys dlndstdrtg lrsdfpdvtf
     1321 dlgvnywddf ddrnlvdasn vccesqqfnp miehhqpahs glssglshcp aqtlqetvsp
     1381 vlpqrvqpma vtpqtamwtn lntntlssdq sqaskgsvqk rfdffsrtda alkentpvgs
     1441 dhtkeisdea hvffdslnlg malvlalgqg lalglalglf lccpalsciv dvalsrlgfa
     1501 nnktvqqlv
//
LOCUS       NP_001429776             265 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized LOC137490038 [Danio rerio].
ACCESSION   NP_001429776
VERSION     NP_001429776.1
DBSOURCE    REFSEQ: accession NM_001442847.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26395062.563716.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..265
                     /product="uncharacterized LOC137490038"
                     /calculated_mol_wt=30242
     CDS             1..265
                     /gene="LOC137490038"
                     /coded_by="NM_001442847.1:198..995"
                     /db_xref="GeneID:137490038"
ORIGIN      
        1 msdpepcrik hedteqqidq ieenteikee ehhvkvedkn hlqtddikrk knsfictecg
       61 ksfsqlyhvn rhmkihtgek pftctqcgks fsqssdlndh mkthtgekpf tctqcgksfs
      121 qsahlnlhmr ihtgekpftc tqcgrsfiql phlnkhmlsh tgekpytctq cgrsfssssn
      181 lnvhmrihtg erpftctqce ksfsqlshln ghlrihtgek pftctqcgks fsqishlnrh
      241 mmshtgerpy tctqkmssss snlnt
//
LOCUS       NP_001429753             675 aa            linear   VRT 27-AUG-2025
DEFINITION  DC-STAMP domain-containing protein 1 isoform 1 [Danio rerio].
ACCESSION   NP_001429753 XP_068070252
VERSION     NP_001429753.1
DBSOURCE    REFSEQ: accession NM_001442824.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 675)
  AUTHORS   Noda,T., Blaha,A., Fujihara,Y., Gert,K.R., Emori,C., Deneke,V.E.,
            Oura,S., Panser,K., Lu,Y., Berent,S., Kodani,M., Cabrera-Quio,L.E.,
            Pauli,A. and Ikawa,M.
  TITLE     Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg
            interaction in mice and fish
  JOURNAL   Commun Biol 5 (1), 332 (2022)
   PUBMED   35393517
  REMARK    GeneRIF: Sperm membrane proteins DCST1 and DCST2 are required for
            sperm-egg interaction in mice and fish.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 675)
  AUTHORS   Molagoda,I.M.N., Kang,C.H., Lee,M.H., Choi,Y.H., Lee,C.M., Lee,S.
            and Kim,G.Y.
  TITLE     Fisetin promotes osteoblast differentiation and osteogenesis
            through GSK-3beta phosphorylation at Ser9 and consequent
            beta-catenin activation, inhibiting osteoporosis
  JOURNAL   Biochem Pharmacol 192, 114676 (2021)
   PUBMED   34256044
  REMARK    Erratum:[Biochem Pharmacol. 2025 Jul;237:116956. doi:
            10.1016/j.bcp.2025.116956. PMID: 40306225]
REFERENCE   3  (residues 1 to 675)
  AUTHORS   Kitamura,K., Takahira,K., Inari,M., Satoh,Y., Hayakawa,K.,
            Tabuchi,Y., Ogai,K., Nishiuchi,T., Kondo,T., Mikuni-Takagaki,Y.,
            Chen,W., Hattori,A. and Suzuki,N.
  TITLE     Zebrafish scales respond differently to in vitro dynamic and static
            acceleration: analysis of interaction between osteoblasts and
            osteoclasts
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 166 (1), 74-80 (2013)
   PUBMED   23632157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000016.1.
            
            On Aug 27, 2025 this sequence version replaced XP_068070252.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.628756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN18715719, SAMN18715720
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     Protein         1..675
                     /product="DC-STAMP domain-containing protein 1 isoform 1"
                     /calculated_mol_wt=77462
     CDS             1..675
                     /gene="dcst1"
                     /coded_by="NM_001442824.1:347..2374"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:556016"
                     /db_xref="ZFIN:ZDB-GENE-070809-5"
ORIGIN      
        1 metrrktphs tleqvckril plrvfkflfg plsefsvarr itgavfgals gaglffgliy
       61 niamttvqhi ivgcvfvglc tlggmfsslf rcsvllmfps migshgrtfl mvfvlhglyq
      121 gpianiqhnv qdvassmgcn idlqithskl mwrmltepyv evvqeiveds eefqneaqnv
      181 smqfqkvrde vmgqygfnsl gkesvhtans tqeeyvaktr arcdyvvqqg itrcqdwfrv
      241 kwdecmntiq vplinhfici pmqfhflcdi mrvmnpwcte kipvegnfgq tfdklndsin
      301 rlaehfttnl vleeleqqav lgvnvlqdfs kelsrefqek taiaekisgv infllsftfi
      361 tvftsafgyv rqycrdilfd nvyittyfrq idarriraek rhllplkkae reslinpwrl
      421 sihaselmpv ivgflqvasl alfvcvllav dgilynifdl irrhtfttys itsvqhadiv
      481 iggdsmlarl lrktigafnt ssnfdiessn ldclpqphsl ilsdylrifi plllmflmcl
      541 lqvysnrlrr vitafyfpkr ekkrilflyn lqiqkrisfi nrqchrlrnp kqtfvmvlsg
      601 vlaplkrvgc rllwccvceg fvrqnqavec ssvgctmiyc qqcwtdldni ccicyprnqc
      661 apqdssydse vyygc
//
LOCUS       NP_001429656             311 aa            linear   VRT 27-AUG-2025
DEFINITION  deoxynucleotidyltransferase terminal interacting protein 1 [Danio
            rerio].
ACCESSION   NP_001429656
VERSION     NP_001429656.1
DBSOURCE    REFSEQ: accession NM_001442727.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 311)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000006.1.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="6"
                     /map="6"
     Protein         1..311
                     /product="deoxynucleotidyltransferase terminal interacting
                     protein 1"
                     /calculated_mol_wt=35381
     CDS             1..311
                     /gene="dnttip1"
                     /coded_by="NM_001442727.1:274..1209"
                     /db_xref="GeneID:100331919"
ORIGIN      
        1 mgahtsegrr dwlqqdfgeq qvqtvnpwni mikhrqvhrr grrsqmavsy tdpiismdll
       61 rtvlqpsfne diravfrkym kffekaasnv kenvggdtqp dqlirdacrn clehakqlfp
      121 eaektapkpi vdptvkrarq pddtsgqrds pvpkkrkgrp pgsgsqyasa qystpaklkv
      181 tepikregpk wdpsrlness tfvlgsrank algmggtrgr iyikhaelfk yaadaqdkhw
      241 lserqhmrat ggkmayllie edildlarsd dykdspelkm delkpfsvpi wmvekmqkam
      301 evqksenela v
//
LOCUS       NP_001429773             265 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized LOC137490038 [Danio rerio].
ACCESSION   NP_001429773
VERSION     NP_001429773.1
DBSOURCE    REFSEQ: accession NM_001442844.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26395012.10016.1,
                                           SRR32588717.43917057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505374, SAMEA3505376
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..265
                     /product="uncharacterized LOC137490038"
                     /calculated_mol_wt=30242
     CDS             1..265
                     /gene="LOC137490038"
                     /coded_by="NM_001442844.1:198..995"
                     /db_xref="GeneID:137490038"
ORIGIN      
        1 msdpepcrik hedteqqidq ieenteikee ehhvkvedkn hlqtddikrk knsfictecg
       61 ksfsqlyhvn rhmkihtgek pftctqcgks fsqssdlndh mkthtgekpf tctqcgksfs
      121 qsahlnlhmr ihtgekpftc tqcgrsfiql phlnkhmlsh tgekpytctq cgrsfssssn
      181 lnvhmrihtg erpftctqce ksfsqlshln ghlrihtgek pftctqcgks fsqishlnrh
      241 mmshtgerpy tctqkmssss snlnt
//
LOCUS       NP_001188383             384 aa            linear   VRT 27-AUG-2025
DEFINITION  serpin peptidase inhibitor, clade B (ovalbumin), member 1-like
            [Danio rerio].
ACCESSION   NP_001188383
VERSION     NP_001188383.2
DBSOURCE    REFSEQ: accession NM_001201454.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000020.1 and BC153323.1.
            
            On Aug 27, 2025 this sequence version replaced NP_001188383.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588730.11296134.1,
                                           SRR32588719.10287360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505371,
                                           SAMEA3505372 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     Protein         1..384
                     /product="serpin peptidase inhibitor, clade B (ovalbumin),
                     member 1-like"
                     /calculated_mol_wt=43503
     CDS             1..384
                     /gene="LOC569077"
                     /coded_by="NM_001201454.2:95..1249"
                     /db_xref="GeneID:569077"
ORIGIN      
        1 megvsransl faldlyrals assaegniff splsisaals mvylgargdt aaemervlsl
       61 ssvsdvhshf eslissinsp sasyilrlan rlygektfsf lpeyldstmk lyhaelqtvd
      121 firaseesrq linkwvekqt enkirdllkp gmvttmtrla lvnaiyfkgk wthtfqakyt
      181 remafkinqk eshpvrmmhq lnklpfrclp eyklqvlelp yirqelsmli llpdetkdgs
      241 dpllklekel tleklldwtn rdkmdtqgav ivhlpkfkle iesclsetle kmgmssvfqe
      301 tkadltgmgs ngglfvsavi hkafvdvsee gteaaaatcv yiitsyvprp epryyftadh
      361 pfmffirhnp snnilflgry rsps
//
LOCUS       NP_001429760            1448 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 1 [Danio rerio].
ACCESSION   NP_001429760 XP_073781303
VERSION     NP_001429760.1
DBSOURCE    REFSEQ: accession NM_001442831.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1448)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            On Aug 27, 2025 this sequence version replaced XP_073781303.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588730.11851395.1,
                                           SRR32588722.19254886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1448
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     1"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=162347
     CDS             1..1448
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442831.1:101..4447"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh dgyidelgdg ytehvnpale hpqlsdlpqk
     1261 mtfdsqpkph sdgnmpritl nkarvysdln dstdrtglrs dfpdvtfdlg vnywddfddr
     1321 nlvdasnvcc esqqfnpmie hhqpahsgls sglshcpaqt lqetvspvlp qrvqpmavtp
     1381 qtamwtnlnt ntlssdqsqa skgsvqkrfd ffsrtdaalk entpvgsdht keisdeahvf
     1441 fgmfdglf
//
LOCUS       NP_001429771             209 aa            linear   VRT 27-AUG-2025
DEFINITION  oocyte zinc finger protein XlCOF6-like [Danio rerio].
ACCESSION   NP_001429771
VERSION     NP_001429771.1
DBSOURCE    REFSEQ: accession NM_001442842.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 209)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..209
                     /product="oocyte zinc finger protein XlCOF6-like"
                     /calculated_mol_wt=24298
     CDS             1..209
                     /gene="LOC137490242"
                     /coded_by="NM_001442842.1:193..822"
                     /db_xref="GeneID:137490242"
ORIGIN      
        1 msdpepcrik hedteqqidl ieeyeqikee ehhvnieeny lqtdgilkst dknrftctqc
       61 grslarlsnl kvhmrihtge kpytcphcgk nfsrrpslyr hlkihtgekp ytctqcgrsf
      121 iqsahlnqhi rihtgekpft ctqcgntfnh sssfnlhmks htgireymcl ecdksfitag
      181 dlkrhqriht gekpykcshp ykkkrtavn
//
LOCUS       NP_001429770             426 aa            linear   VRT 27-AUG-2025
DEFINITION  gastrula zinc finger protein XlCGF57.1 [Danio rerio].
ACCESSION   NP_001429770
VERSION     NP_001429770.1
DBSOURCE    REFSEQ: accession NM_001442841.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..426
                     /product="gastrula zinc finger protein XlCGF57.1"
                     /calculated_mol_wt=49667
     CDS             1..426
                     /gene="LOC110439310"
                     /coded_by="NM_001442841.1:126..1406"
                     /db_xref="GeneID:110439310"
ORIGIN      
        1 msdpepcrik hedteqqidl ikeneemkee ehhvrieenh lqtddilksg dknhftctqc
       61 grslarqsnl kvhmmihtge kphtctqcgk sfrrssnlkr hmmshigekl ftcaqceksf
      121 sqssnlklhm rihtgeklfi ctqcgkrfyk lehfnqhmmi htgekpytct qcgksfsqss
      181 nlnqhmkiht dlieeyeeik eeehhvniee khlqtddilk krdknrlict qcgksfgrks
      241 slkihmriht gekpftctec gmsfrqssdl nqhmmihtge kpytcpqcer sfsrlsnlne
      301 hmkihagerp ytctqcgksf crishfnehm rihtgekpft ctqcgmsfsc ssnlikhmrt
      361 htgekpfict pcgtsfsqss slklhmmiht gekpykcshc ekkfrdlqal krherihtge
      421 qwcpnf
//
LOCUS       NP_001429774             265 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized LOC137490038 [Danio rerio].
ACCESSION   NP_001429774
VERSION     NP_001429774.1
DBSOURCE    REFSEQ: accession NM_001442845.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.25262312.1,
                                           SRR32588730.22002345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06350655, SAMN06645146
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..265
                     /product="uncharacterized LOC137490038"
                     /calculated_mol_wt=30242
     CDS             1..265
                     /gene="LOC137490038"
                     /coded_by="NM_001442845.1:269..1066"
                     /db_xref="GeneID:137490038"
ORIGIN      
        1 msdpepcrik hedteqqidq ieenteikee ehhvkvedkn hlqtddikrk knsfictecg
       61 ksfsqlyhvn rhmkihtgek pftctqcgks fsqssdlndh mkthtgekpf tctqcgksfs
      121 qsahlnlhmr ihtgekpftc tqcgrsfiql phlnkhmlsh tgekpytctq cgrsfssssn
      181 lnvhmrihtg erpftctqce ksfsqlshln ghlrihtgek pftctqcgks fsqishlnrh
      241 mmshtgerpy tctqkmssss snlnt
//
LOCUS       NP_001429758             818 aa            linear   VRT 27-AUG-2025
DEFINITION  Uncharacterized LOC143174136 [Danio rerio].
ACCESSION   NP_001429758
VERSION     NP_001429758.1
DBSOURCE    REFSEQ: accession NM_001442829.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..818
                     /product="Uncharacterized LOC143174136"
                     /calculated_mol_wt=88510
     CDS             1..818
                     /gene="LOC143174136"
                     /coded_by="NM_001442829.1:161..2617"
                     /db_xref="GeneID:143174136"
ORIGIN      
        1 mkdaavvcrq mgcggavsap nnvsfgqgsg piwlnnvrcs gnesslrdcs hhgfgvnnsr
       61 hyedagvvcl kdirlvggfh scsgrveily ngtwgtvrdd nwdmkdaavv crqmgcggav
      121 sapnnvsfgr gsgpiwlnnv rcsgnesslr dcshhgfgvn nsrhyedagv vclkdirlvg
      181 gfhscsgrve ilyngtwgtv cdddwdmnda avvcrqmgcg eaiskesdas fglesgqiwl
      241 dgvrcsgses tlrdcshrgf gvnnckhqky agvvcldirl vggfhscsgr veilynstwg
      301 tvcdddwdmn daavvcrqmg cgravsapqs asfgqgrnqi wlndvkcsgn essltncshr
      361 gfgvnncghq kdaevvcldi rlvppifnkf dsccgrveih hngewgsvcd enwdmndaav
      421 vcrqlqcgsa isapysaafg egsgsiwlde vnctgseesl iqcshngvgk hncnhgevag
      481 vvcygtagel qmaslalist hsvvspgeiv qfrcstpkpr csanaefhlf ingsslssqt
      541 hvsnvtfsin vdvshhgeys cqysyqrslk stlsntvtit vvhlqqpsis psapdggfvv
      601 gpqgpvitrg hsftitcstk sqypggsfyl fresnisriq ryvslsasfs fpeadysdeg
      661 nyscvyevsv ssrsfrssas elllititas llsavigaal saglllltvl iivmflkrrq
      721 kkkedrskcs fkkgpvnkia ggshdstcnd dkkdddnddd ddddepdyen pecdenmkhe
      781 vseedyeivd dddhdaddae qdyinvdldd seedyinf
//
LOCUS       NP_001429754             623 aa            linear   VRT 27-AUG-2025
DEFINITION  DC-STAMP domain-containing protein 1 isoform 2 [Danio rerio].
ACCESSION   NP_001429754 XP_073782191
VERSION     NP_001429754.1
DBSOURCE    REFSEQ: accession NM_001442825.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Noda,T., Blaha,A., Fujihara,Y., Gert,K.R., Emori,C., Deneke,V.E.,
            Oura,S., Panser,K., Lu,Y., Berent,S., Kodani,M., Cabrera-Quio,L.E.,
            Pauli,A. and Ikawa,M.
  TITLE     Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg
            interaction in mice and fish
  JOURNAL   Commun Biol 5 (1), 332 (2022)
   PUBMED   35393517
  REMARK    GeneRIF: Sperm membrane proteins DCST1 and DCST2 are required for
            sperm-egg interaction in mice and fish.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 623)
  AUTHORS   Molagoda,I.M.N., Kang,C.H., Lee,M.H., Choi,Y.H., Lee,C.M., Lee,S.
            and Kim,G.Y.
  TITLE     Fisetin promotes osteoblast differentiation and osteogenesis
            through GSK-3beta phosphorylation at Ser9 and consequent
            beta-catenin activation, inhibiting osteoporosis
  JOURNAL   Biochem Pharmacol 192, 114676 (2021)
   PUBMED   34256044
  REMARK    Erratum:[Biochem Pharmacol. 2025 Jul;237:116956. doi:
            10.1016/j.bcp.2025.116956. PMID: 40306225]
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Kitamura,K., Takahira,K., Inari,M., Satoh,Y., Hayakawa,K.,
            Tabuchi,Y., Ogai,K., Nishiuchi,T., Kondo,T., Mikuni-Takagaki,Y.,
            Chen,W., Hattori,A. and Suzuki,N.
  TITLE     Zebrafish scales respond differently to in vitro dynamic and static
            acceleration: analysis of interaction between osteoblasts and
            osteoclasts
  JOURNAL   Comp Biochem Physiol A Mol Integr Physiol 166 (1), 74-80 (2013)
   PUBMED   23632157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000016.1.
            
            On Aug 27, 2025 this sequence version replaced XP_073782191.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.29042693.1,
                                           SRR32588725.1124258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN18715719, SAMN18715720
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     Protein         1..623
                     /product="DC-STAMP domain-containing protein 1 isoform 2"
                     /calculated_mol_wt=71416
     CDS             1..623
                     /gene="dcst1"
                     /coded_by="NM_001442825.1:543..2414"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:556016"
                     /db_xref="ZFIN:ZDB-GENE-070809-5"
ORIGIN      
        1 mcvcgfspga avsptspktc vldelglctl ggmfsslfrc svllmfpsmi gshgrtflmv
       61 fvlhglyqgp ianiqhnvqd vassmgcnid lqithsklmw rmltepyvev vqeivedsee
      121 fqneaqnvsm qfqkvrdevm gqygfnslgk esvhtanstq eeyvaktrar cdyvvqqgit
      181 rcqdwfrvkw decmntiqvp linhficipm qfhflcdimr vmnpwcteki pvegnfgqtf
      241 dklndsinrl aehfttnlvl eeleqqavlg vnvlqdfske lsrefqekta iaekisgvin
      301 fllsftfitv ftsafgyvrq ycrdilfdnv yittyfrqid arriraekrh llplkkaere
      361 slinpwrlsi haselmpviv gflqvaslal fvcvllavdg ilynifdlir rhtfttysit
      421 svqhadivig gdsmlarllr ktigafntss nfdiessnld clpqphslil sdylrifipl
      481 llmflmcllq vysnrlrrvi tafyfpkrek krilflynlq iqkrisfinr qchrlrnpkq
      541 tfvmvlsgvl aplkrvgcrl lwccvcegfv rqnqavecss vgctmiycqq cwtdldnicc
      601 icyprnqcap qdssydsevy ygc
//
LOCUS       NP_001429757             670 aa            linear   VRT 27-AUG-2025
DEFINITION  low affinity immunoglobulin gamma Fc region receptor II-b-like
            precursor [Danio rerio].
ACCESSION   NP_001429757
VERSION     NP_001429757.1
DBSOURCE    REFSEQ: accession NM_001442828.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..670
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b-like precursor"
                     /calculated_mol_wt=70623
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2119
     CDS             1..670
                     /gene="LOC137490184"
                     /coded_by="NM_001442828.1:32..2044"
                     /db_xref="GeneID:137490184"
ORIGIN      
        1 mprslqlifi lasaltsvtg yslrlvngtn dcsgrveily ngvwgtvcdd swdlndaavv
       61 crqlgcggav nasqsasfgq gsgqiwldnv gcsgsesslt dcshrgfgeh ncghhedagv
      121 vclkdirlvg gnyscsgrve ilyngmwgtv cdddwdmnna avvcrqmgcg gavsapqras
      181 fgqgngriwl ddvrcsgqef sltncshrgf gehdcghhed agvvcldirl vdgldsccgr
      241 veihhngvwg svcndnwdmn daavvcrqlq cgsaisaphs aafgpgngsi wldevnctgs
      301 etrltqcshs glgnhncdhs kdagvvcyag elqraslali sthsvvspge nvhfrcstpk
      361 prcsanaefq lfingsslss qthvsnvtfs lnvdvshhge yscqysyqss lkstlsntvt
      421 itvvhlqqps ispsapddef vvgpqrpvit rghsftitcs tksqypggff ylfkesnisr
      481 iepsvslsas fffpeadysh egnyscvyev rvssrsfrss aselllitit asllpaviga
      541 alsaglllla ifiivlslkr rqkkkedhsk csfkkgpant yagashnnry eddddnddep
      601 dyenaecden mkhedseedy vnvdddddae edyinvnsdn seedyvnmdi kensnmtnks
      661 ddnlyeivkn
//
LOCUS       NP_001429761            1448 aa            linear   VRT 27-AUG-2025
DEFINITION  probable ATP-dependent DNA helicase HFM1 isoform 1 [Danio rerio].
ACCESSION   NP_001429761
VERSION     NP_001429761.1
DBSOURCE    REFSEQ: accession NM_001442832.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 1448)
  AUTHORS   Ma,J., Gu,Y., Liu,J., Song,J., Zhou,T., Jiang,M., Wen,Y., Guo,X.,
            Zhou,Z., Sha,J., He,J., Hu,Z., Luo,L. and Liu,M.
  TITLE     Functional screening of congenital heart disease risk loci
            identifies 5 genes essential for heart development in zebrafish
  JOURNAL   Cell Mol Life Sci 80 (1), 19 (2022)
   PUBMED   36574072
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588722.38944782.1,
                                           SRR32588718.5379857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     Protein         1..1448
                     /product="probable ATP-dependent DNA helicase HFM1 isoform
                     1"
                     /EC_number="3.6.4.12"
                     /note="HFM1, ATP-dependent DNA helicase homolog"
                     /calculated_mol_wt=162347
     CDS             1..1448
                     /gene="hfm1"
                     /gene_synonym="si:ch211-83f14.5"
                     /coded_by="NM_001442832.1:63..4409"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="GeneID:557052"
                     /db_xref="ZFIN:ZDB-GENE-061207-43"
ORIGIN      
        1 mvdseesvss ldnlfydrpv ihkvkplcqg qgswvwdapp slsqipstqd iqreaahass
       61 fsfsqrsktf lppaqkpihn ptegiqgqtv qsheleepgl wshepsstge qavfrmgfae
      121 trplptasap pfktrlfqas trrtsgnged gisnqtlstt ndtafqsqap rrtsgpqaah
      181 avaacspfig laqteekcdv psshslhlgl kpaefkgsse kgtlrsvsei pakfrsvfkd
      241 fpyfnyvqsq alddvlysnk nfvacaptgs gktvlfelai vrllieasep whnvravyma
      301 pikalcsqqy dnwkqkfgpl glkckeltgd teiddffeiq dahlifttae kwdsmtrrwk
      361 dnclltsirl flvdevhvvk dktrgatlev vvsrmktmhf yrqainpesk asvrfvavsa
      421 tipniqdvse wlsdesgpat clemdeshrp vklrkvvlgf pcgsnqnefk fdlslnykla
      481 niiqtysdqk ptlvfcstrk gvqqsasvla kdarfimsid hkqrlvkyan slldaklrdl
      541 fvygigyhha gmdvsdrkit enaftvgdlp vlfttstlam gvnmpahlvv ikstmhyvgg
      601 aceeyseadl lqmigragrp qfdttatavi mtrpqtkdky mhflsgldci esslhtnlve
      661 hlnaeivlht isdvnmaldw irstflyira lknpkhygfp pevdkcgiet klqelclknl
      721 nslasfnlit mdedinikpt etgklmaryc vafdtvkqfs mvtgtetlpe liemiskake
      781 fsdmqlrvne rktlntlnkd knrttirfpi egkiksndmk vncliqaqlg cipiqefgli
      841 qdtgkifrna vrvsryltef lchhsksnfa aqlnalilak cfraklwens pyiskqleri
      901 glslatalvn aglttfskie qtspreleli vnrhppfgnq ikeaisklpr cevsleqipr
      961 yspstaeivf tvnmnnfkel alkrtapdhh yvtlivgdcd nkvvfqqkis dtlllksgsw
     1021 skrievtrsp kgeelsihli sseyvgldiq qdysahysgv hglqaefsit ekptwrfqri
     1081 hdtmkkrqgp tvatpnssvn dilfvdqvap nmvkrnchhl cknkelcrhd cckigvkrtv
     1141 lqsnvssyld nlkmrneklc etpvkrlkmm mnngtaavsm qqfsykpkdt hsaakrfegs
     1201 qcytqsayqi qdleasfatp sqnssseawh dgyidelgdg ytehvnpale hpqlsdlpqk
     1261 mtfdsqpkph sdgnmpritl nkarvysdln dstdrtglrs dfpdvtfdlg vnywddfddr
     1321 nlvdasnvcc esqqfnpmie hhqpahsgls sglshcpaqt lqetvspvlp qrvqpmavtp
     1381 qtamwtnlnt ntlssdqsqa skgsvqkrfd ffsrtdaalk entpvgsdht keisdeahvf
     1441 fgmfdglf
//
LOCUS       NP_001429772             265 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized LOC137490038 [Danio rerio].
ACCESSION   NP_001429772
VERSION     NP_001429772.1
DBSOURCE    REFSEQ: accession NM_001442843.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26395028.889843.1,
                                           SRR26395062.1036159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505381, SAMEA3505382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..265
                     /product="uncharacterized LOC137490038"
                     /calculated_mol_wt=30242
     CDS             1..265
                     /gene="LOC137490038"
                     /coded_by="NM_001442843.1:126..923"
                     /db_xref="GeneID:137490038"
ORIGIN      
        1 msdpepcrik hedteqqidq ieenteikee ehhvkvedkn hlqtddikrk knsfictecg
       61 ksfsqlyhvn rhmkihtgek pftctqcgks fsqssdlndh mkthtgekpf tctqcgksfs
      121 qsahlnlhmr ihtgekpftc tqcgrsfiql phlnkhmlsh tgekpytctq cgrsfssssn
      181 lnvhmrihtg erpftctqce ksfsqlshln ghlrihtgek pftctqcgks fsqishlnrh
      241 mmshtgerpy tctqkmssss snlnt
//
LOCUS       NP_002030                694 aa            linear   PRI 27-AUG-2025
DEFINITION  GRB2-associated-binding protein 1 isoform b [Homo sapiens].
ACCESSION   NP_002030
VERSION     NP_002030.2
DBSOURCE    REFSEQ: accession NM_002039.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 694)
  AUTHORS   Nam,D.E., Park,S.J., Omole,S., Um,E., Hakami,R.M. and Hahn,Y.S.
  TITLE     Activated Gab1 drives hepatocyte proliferation and anti-apoptosis
            in liver fibrosis via potential involvement of the HGF/c-Met
            signaling axis
  JOURNAL   PLoS One 19 (6), e0306345 (2024)
   PUBMED   38935609
  REMARK    GeneRIF: Activated Gab1 drives hepatocyte proliferation and
            anti-apoptosis in liver fibrosis via potential involvement of the
            HGF/c-Met signaling axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 694)
  AUTHORS   Zhang,Y., Liu,J., Zhi,Y., You,X. and Wei,B.
  TITLE     Association of GAB1 gene with asthma susceptibility and the
            efficacy of inhaled corticosteroids in children
  JOURNAL   BMC Pulm Med 23 (1), 493 (2023)
   PUBMED   38057792
  REMARK    GeneRIF: Association of GAB1 gene with asthma susceptibility and
            the efficacy of inhaled corticosteroids in children.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 694)
  AUTHORS   Boetto,J., Bielle,F., Tran,S., Marijon,P., Peyre,M., Rigau,V. and
            Kalamarides,M.
  TITLE     GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma
  JOURNAL   Neurosurgery 92 (2), 391-397 (2023)
   PUBMED   36637273
  REMARK    GeneRIF: GAB1 as a Marker of Recurrence in Anterior Skull Base
            Meningioma.
REFERENCE   4  (residues 1 to 694)
  AUTHORS   Li,J., Yang,N., Tian,X., Ouyang,L., Jiang,M. and Zhang,S.
  TITLE     Interference of PTK6/GAB1 signaling inhibits cell proliferation,
            invasion, and migration of cervical cancer cells
  JOURNAL   Mol Med Rep 26 (3) (2022)
   PUBMED   35894144
  REMARK    GeneRIF: Interference of PTK6/GAB1 signaling inhibits cell
            proliferation, invasion, and migration of cervical cancer cells.
REFERENCE   5  (residues 1 to 694)
  AUTHORS   Chen,J., Kang,Z., Li,S., Wang,C., Zheng,X., Cai,Z., Pan,L., Chen,F.
            and Li,W.
  TITLE     Molecular profile reveals immune-associated markers of
            medulloblastoma for different subtypes
  JOURNAL   Front Immunol 13, 911260 (2022)
   PUBMED   35967388
  REMARK    GeneRIF: Molecular profile reveals immune-associated markers of
            medulloblastoma for different subtypes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 694)
  AUTHORS   Holgado-Madruga,M., Moscatello,D.K., Emlet,D.R., Dieterich,R. and
            Wong,A.J.
  TITLE     Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase
            activation and the promotion of cell survival by nerve growth
            factor
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12419-12424 (1997)
   PUBMED   9356464
REFERENCE   7  (residues 1 to 694)
  AUTHORS   Nguyen,L., Holgado-Madruga,M., Maroun,C., Fixman,E.D., Kamikura,D.,
            Fournier,T., Charest,A., Tremblay,M.L., Wong,A.J. and Park,M.
  TITLE     Association of the multisubstrate docking protein Gab1 with the
            hepatocyte growth factor receptor requires a functional Grb2
            binding site involving tyrosine 1356
  JOURNAL   J Biol Chem 272 (33), 20811-20819 (1997)
   PUBMED   9252406
REFERENCE   8  (residues 1 to 694)
  AUTHORS   Fixman,E.D., Holgado-Madruga,M., Nguyen,L., Kamikura,D.M.,
            Fournier,T.M., Wong,A.J. and Park,M.
  TITLE     Efficient cellular transformation by the Met oncoprotein requires a
            functional Grb2 binding site and correlates with phosphorylation of
            the Grb2-associated proteins, Cbl and Gab1
  JOURNAL   J Biol Chem 272 (32), 20167-20172 (1997)
   PUBMED   9242692
REFERENCE   9  (residues 1 to 694)
  AUTHORS   Kanai,M., Goke,M., Tsunekawa,S. and Podolsky,D.K.
  TITLE     Signal transduction pathway of human fibroblast growth factor
            receptor 3. Identification of a novel 66-kDa phosphoprotein
  JOURNAL   J Biol Chem 272 (10), 6621-6628 (1997)
   PUBMED   9045692
REFERENCE   10 (residues 1 to 694)
  AUTHORS   Holgado-Madruga,M., Emlet,D.R., Moscatello,D.K., Godwin,A.K. and
            Wong,A.J.
  TITLE     A Grb2-associated docking protein in EGF- and insulin-receptor
            signalling
  JOURNAL   Nature 379 (6565), 560-564 (1996)
   PUBMED   8596638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA109618.1, AK289767.1,
            AK022142.1, DA249555.1, AC104685.2, BC030115.1 and AL049449.1.
            
            On Apr 14, 2004 this sequence version replaced NP_002030.1.
            
            Summary: The protein encoded by this gene is a member of the
            IRS1-like multisubstrate docking protein family. It is an important
            mediator of branching tubulogenesis and plays a central role in
            cellular growth response, transformation and apoptosis. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon
            compared to variant 1, resulting in a shorter isoform (b) with the
            same N- and C-termini, but missing a 30 aa protein segment compared
            to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.48357.1,
                                           SRR1660809.95651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262994.9/ ENSP00000262994.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     Protein         1..694
                     /product="GRB2-associated-binding protein 1 isoform b"
                     /note="GRB2-associated binder 1; growth factor receptor
                     bound protein 2-associated protein 1; deafness, autosomal
                     recessive 26"
                     /calculated_mol_wt=76485
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:22223895; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Region          3..125
                     /region_name="PH_Gab1_Gab2"
                     /note="Grb2-associated binding proteins 1 and 2 pleckstrin
                     homology (PH) domain; cd01266"
                     /db_xref="CDD:241297"
     Region          122..164
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Region          194..231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            253
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            266
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Region          323..386
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Site            387
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            454
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYY0; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Region          493..532
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Region          544..656
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Site            547
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            627
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            651
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Site            659
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     Region          671..694
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13480.2)"
     Site            683
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13480.2)"
     CDS             1..694
                     /gene="GAB1"
                     /gene_synonym="DFNB26"
                     /coded_by="NM_002039.4:314..2398"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS3759.1"
                     /db_xref="GeneID:2549"
                     /db_xref="HGNC:HGNC:4066"
                     /db_xref="MIM:604439"
ORIGIN      
        1 msggevvcsg wlrksppekk lkryawkrrw fvlrsgrltg dpdvleyykn dhakkpirii
       61 dlnlcqqvda gltfnkkefe nsyifdinti drifylvads eeemnkwvrc icdicgfnpt
      121 eedpvkppgs slqapadlpl aintappstq adsssatlpp pyqlinvpph letlgiqedp
      181 qdylllincq skkpeptrth adsakstsse tdcndnvpsh knpassqskh gmngffqqqm
      241 iydsppsrap sasvdsslyn lprsyshdvl pkvspsstea dgelyvfntp sgtssvetqm
      301 rhvsisydip ptpgntyqip rtfpegtlgq tskldtipdi ppprppkphp ahdrspvetc
      361 siprtasdtd ssyciptagm spsrsntist vdlnklrkda ssqdcydipr afpsdrsssl
      421 egfhnhfkvk nvltvgsvss eeldenyvpm npnspprqhs ssftepiqea nyvpmtpgtf
      481 dfssfgmqvp ppahmgfrss pktpprrpvp vadcepppvd rnlkpdrkvk papleikplp
      541 eweelqapvr spitrsfard ssrfpmsprp dsvhsttsss dshdseenyv pmnpnlssed
      601 pnlfgsnsld ggsspmikpk gdkqveyldl dldsgkstpp rkqkssgsgs svadervdyv
      661 vvdqqktlal kstreawtdg rqstesetpa ksvk
//
LOCUS       NP_001128308             244 aa            linear   PRI 27-AUG-2025
DEFINITION  signal-regulatory protein beta-2 isoform 2 precursor [Homo
            sapiens].
ACCESSION   NP_001128308
VERSION     NP_001128308.1
DBSOURCE    REFSEQ: accession NM_001134836.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 244)
  AUTHORS   Song,Q., Qin,S., Pascal,L.E., Zou,C., Wang,W., Tong,H., Zhang,J.,
            Catalona,W.J., Dhir,R., Morrell,M., Balasubramani,G.K., Lu,Y. and
            Wang,Z.
  TITLE     SIRPB1 promotes prostate cancer cell proliferation via Akt
            activation
  JOURNAL   Prostate 80 (4), 352-364 (2020)
   PUBMED   31905248
  REMARK    GeneRIF: Results suggest that SIRPB1 is a potential oncogene
            capable of activating Akt signaling to stimulate prostate cancer
            proliferation and could be a biomarker for patients at risk of
            developing aggressive prostate cancer.
REFERENCE   2  (residues 1 to 244)
  AUTHORS   Reiner,A.P., Hartiala,J., Zeller,T., Bis,J.C., Dupuis,J.,
            Fornage,M., Baumert,J., Kleber,M.E., Wild,P.S., Baldus,S.,
            Bielinski,S.J., Fontes,J.D., Illig,T., Keating,B.J., Lange,L.A.,
            Ojeda,F., Muller-Nurasyid,M., Munzel,T.F., Psaty,B.M., Rice,K.,
            Rotter,J.I., Schnabel,R.B., Tang,W.H., Thorand,B., Erdmann,J.,
            Jacobs,D.R. Jr., Wilson,J.G., Koenig,W., Tracy,R.P.,
            Blankenberg,S., Marz,W., Gross,M.D., Benjamin,E.J., Hazen,S.L. and
            Allayee,H.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Genome-wide and gene-centric analyses of circulating
            myeloperoxidase levels in the charge and care consortia
  JOURNAL   Hum Mol Genet 22 (16), 3381-3393 (2013)
   PUBMED   23620142
REFERENCE   3  (residues 1 to 244)
  AUTHORS   Nyati,M.K., Feng,F.Y., Maheshwari,D., Varambally,S., Zielske,S.P.,
            Ahsan,A., Chun,P.Y., Arora,V.A., Davis,M.A., Jung,M., Ljungman,M.,
            Canman,C.E., Chinnaiyan,A.M. and Lawrence,T.S.
  TITLE     Ataxia telangiectasia mutated down-regulates phospho-extracellular
            signal-regulated kinase 1/2 via activation of MKP-1 in response to
            radiation
  JOURNAL   Cancer Res 66 (24), 11554-11559 (2006)
   PUBMED   17178844
  REMARK    GeneRIF: Relationship between ATM kinase and extracellular
            signal-regulated kinase 1/2 (ERK1/2), a key mitogenic stimulator.
REFERENCE   4  (residues 1 to 244)
  AUTHORS   Barclay,A.N. and Brown,M.H.
  TITLE     The SIRP family of receptors and immune regulation
  JOURNAL   Nat Rev Immunol 6 (6), 457-464 (2006)
   PUBMED   16691243
  REMARK    Review article
REFERENCE   5  (residues 1 to 244)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   6  (residues 1 to 244)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK297072.1, AL109658.5 and AK095499.1.
            
            Transcript Variant: This variant (2) lacks an in-frame segment of
            the coding region, compared to version 1, that results in a shorter
            protein (isoform 2) that lacks one of two immunoglobulin domains,
            when compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.485708.1,
                                           DRR138517.1079173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     Protein         1..244
                     /product="signal-regulatory protein beta-2 isoform 2
                     precursor"
                     /note="protein tyrosine phosphatase, non-receptor type
                     substrate 1-like 3; SIRP-beta-2; protein tyrosine
                     phosphatase non-receptor type substrate protein"
                     /calculated_mol_wt=22596
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3260
     Region          63..166
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          78..82
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          92..96
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          127..131
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..146
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..161
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..244
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /coded_by="NM_001134836.2:62..796"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS46570.1"
                     /db_xref="GeneID:284759"
                     /db_xref="HGNC:HGNC:16247"
                     /db_xref="MIM:621323"
ORIGIN      
        1 mcstmsaptc lahlppcfll lalvlvpsda sgqssrndwq vlqpegpmlv aegagdpepd
       61 lwiiqpqelv lgttgdtvfl nctvlgdgpp gpirwfqgag lsreaiynfg gishpketav
      121 qasnndfsil lqnvssedag tyycvkfqrk pnrqylsgqg tslkvkakst sskeaeftse
      181 patemsptgl lvvfapvvlg lkaitlaall lalatsrrsp gqedvkttgp agamntlaws
      241 kgqe
//
LOCUS       NP_001002660             488 aa            linear   VRT 27-AUG-2025
DEFINITION  sestrin-1 [Danio rerio].
ACCESSION   NP_001002660
VERSION     NP_001002660.1
DBSOURCE    REFSEQ: accession NM_001002660.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Chen,Z., Zhou,Z., Peng,X., Sun,C., Yang,D., Li,C., Zhu,R.,
            Zhang,P., Zheng,L. and Tang,C.
  TITLE     Cardioprotective responses to aerobic exercise-induced
            physiological hypertrophy in zebrafish heart
  JOURNAL   J Physiol Sci 71 (1), 33 (2021)
   PUBMED   34749643
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Zhao,T., Ye,S., Tang,Z., Guo,L., Ma,Z., Zhang,Y., Yang,C., Peng,J.
            and Chen,J.
  TITLE     Loss-of-function of p53 isoform Delta113p53 accelerates brain aging
            in zebrafish
  JOURNAL   Cell Death Dis 12 (2), 151 (2021)
   PUBMED   33542214
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Smeeton,J., Natarajan,N., Naveen Kumar,A., Miyashita,T., Baddam,P.,
            Fabian,P., Graf,D. and Crump,J.G.
  TITLE     Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia
            reveals post-embryonic roles of Nkx3.2 in the skeleton
  JOURNAL   Development 148 (2) (2021)
   PUBMED   33462117
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Ye,S., Zhao,T., Zhang,W., Tang,Z., Gao,C., Ma,Z., Xiong,J.W.,
            Peng,J., Tan,W.Q. and Chen,J.
  TITLE     p53 isoform Delta113p53 promotes zebrafish heart regeneration by
            maintaining redox homeostasis
  JOURNAL   Cell Death Dis 11 (7), 568 (2020)
   PUBMED   32703938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Wu,J., Yang,Y., He,Y., Li,Q., Wang,X., Sun,C., Wang,L., An,Y. and
            Luo,F.
  TITLE     EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits
            chondrocyte differentiation via activation of the p53 signaling
            pathway
  JOURNAL   Hum Genomics 13 (1), 63 (2019)
   PUBMED   31806011
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Emerson,S.E., St Clair,R.M., Waldron,A.L., Bruno,S.R., Duong,A.,
            Driscoll,H.E., Ballif,B.A., McFarlane,S. and Ebert,A.M.
  TITLE     Identification of target genes downstream of semaphorin6A/PlexinA2
            signaling in zebrafish
  JOURNAL   Dev Dyn 246 (7), 539-549 (2017)
   PUBMED   28440030
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Mihaljevic,I., Popovic,M., Zaja,R. and Smital,T.
  TITLE     Phylogenetic, syntenic, and tissue expression analysis of slc22
            genes in zebrafish (Danio rerio)
  JOURNAL   BMC Genomics 17 (1), 626 (2016)
   PUBMED   27519738
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Nourizadeh-Lillabadi,R., Seilo Torgersen,J., Vestrheim,O.,
            Konig,M., Alestrom,P. and Syed,M.
  TITLE     Early embryonic gene expression profiling of zebrafish prion
            protein (Prp2) morphants
  JOURNAL   PLoS One 5 (10), e13573 (2010)
   PUBMED   21042590
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Peeters,H., Voz,M.L., Verschueren,K., De Cat,B., Pendeville,H.,
            Thienpont,B., Schellens,A., Belmont,J.W., David,G., Van De
            Ven,W.J., Fryns,J.P., Gewillig,M., Huylebroeck,D., Peers,B. and
            Devriendt,K.
  TITLE     Sesn1 is a novel gene for left-right asymmetry and mediating nodal
            signaling
  JOURNAL   Hum Mol Genet 15 (22), 3369-3377 (2006)
   PUBMED   17038485
  REMARK    GeneRIF: identify SESN1 as an indispensable gene for vertebrate
            left-right asymmetry and a new player in mediating Nodal signaling
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076550.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076550.1, DQ858215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     Protein         1..488
                     /product="sestrin-1"
                     /EC_number="1.11.1.15"
                     /calculated_mol_wt=56462
     Region          47..487
                     /region_name="PA26"
                     /note="PA26 p53-induced protein (sestrin); pfam04636"
                     /db_xref="CDD:461375"
     CDS             1..488
                     /gene="sesn1"
                     /gene_synonym="si:ch211-51a19.4; zgc:103669; zgc:91970"
                     /coded_by="NM_001002660.1:115..1581"
                     /db_xref="GeneID:436933"
                     /db_xref="ZFIN:ZDB-GENE-040718-408"
ORIGIN      
        1 mrhalasnet menssltmtd lfkictqcer lskkdvgvri prpvgngpsr fipekeilqv
       61 skldertqsi fedafavlgr ldnislvmgf hpqylesflr tqhyllqmdg plslhcrhyi
      121 gimaaarhqc tylvnlhvnd flqvggdpkw lngleeaprk lqalgelnki lahrpwlltk
      181 ehierllkae ehswslaeli havvllthyh slasftfgcg itpdihtdgg htfrppslsg
      241 ycvcdiangn gaqedmfgnq qvsessgeve vlmermkqlq ecrdeeeasq eematrfere
      301 ktecmlvvts edeecvpsrd vsrhfedpsy gykdfsrrge hvptlrvqdy swedhgfslv
      361 nrlysdfgql ldekfqiafn ltyntmathq gvdtsmlrra iwnyihcmfg iryddydyge
      421 inqlldrsfk vyiktmvcsp ekitkrmyes fwrqfrhsek vhvnlllmea rmqaellyal
      481 raitrymt
//
LOCUS       NP_001428632             417 aa            linear   VRT 27-AUG-2025
DEFINITION  zinc finger protein 568 [Danio rerio].
ACCESSION   NP_001428632 XP_009299293
VERSION     NP_001428632.1
DBSOURCE    REFSEQ: accession NM_001441703.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 417)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000004.1.
            
            On Jun 30, 2025 this sequence version replaced XP_009299293.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588723.1112736.1,
                                           SRR32588734.3647896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476735 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     Protein         1..417
                     /product="zinc finger protein 568"
                     /note="gastrula zinc finger protein XlCGF7.1"
                     /calculated_mol_wt=48465
     CDS             1..417
                     /gene="LOC100333031"
                     /coded_by="NM_001441703.1:103..1356"
                     /db_xref="GeneID:100333031"
ORIGIN      
        1 mafikeesdd lritevftlk redreeqtgm mvlkeetqeq ykmeeedqne ehqdflpdep
       61 ssvtknssce saektksssy fpcqecgkpf cqkssleahm rihtgeslit cdqcgksfsr
      121 ksyfdrhrkt htkekpywct ecgkrftqkn nleghmriht gekpfscqyc gktfrriqnl
      181 nahitlhttk kpyacqqcgt gftkaenlrv hmrihtgekp facehcgkrf rrvqnlkahi
      241 pvhtgekpya cqpcgktftk aenfrvhmrv htgespytca qcgksftqkt glnhhsrvht
      301 gekpptctqc gknfkckynl achmkihtge kpftcdecgk sflrkfhlkq hkwlhrtdkp
      361 facdqcgksf vredyltehm rvhteksfkc drcgksfvhk rtlkvhmakh spkddpq
//
LOCUS       NP_001157753             564 aa            linear   PRI 27-AUG-2025
DEFINITION  E3 ubiquitin ligase TRAF3IP2 isoform 3 [Homo sapiens].
ACCESSION   NP_001157753
VERSION     NP_001157753.1
DBSOURCE    REFSEQ: accession NM_001164281.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 564)
  AUTHORS   Che,J., DePalma,T.J., Sivakumar,H., Mezache,L.S., Tallman,M.M.,
            Venere,M., Swindle-Reilly,K., Veeraraghavan,R. and Skardal,A.
  TITLE     alphaCT1 peptide sensitizes glioma cells to temozolomide in a
            glioblastoma organoid platform
  JOURNAL   Biotechnol Bioeng 120 (4), 1108-1119 (2023)
   PUBMED   36544242
  REMARK    GeneRIF: alphaCT1 peptide sensitizes glioma cells to temozolomide
            in a glioblastoma organoid platform.
REFERENCE   2  (residues 1 to 564)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 564)
  AUTHORS   Yan,Q. and Li,B.
  TITLE     TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation,
            migration, and extracellular matrix deposition in keloid through
            the TGF-beta1/Smad pathway
  JOURNAL   J Cosmet Dermatol 21 (10), 5148-5155 (2022)
   PUBMED   35441794
  REMARK    GeneRIF: TRAF3IP2 regulated by FOXO4 affects fibroblast
            proliferation, migration, and extracellular matrix deposition in
            keloid through the TGF-beta1/Smad pathway.
REFERENCE   4  (residues 1 to 564)
  AUTHORS   De Benedittis,G., Latini,A., Conigliaro,P., Triggianese,P.,
            Bergamini,A., Novelli,L., Ciccacci,C., Chimenti,M.S. and
            Borgiani,P.
  TITLE     A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients
  JOURNAL   Immunobiology 227 (4), 152232 (2022)
   PUBMED   35642993
  REMARK    GeneRIF: A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients.
REFERENCE   5  (residues 1 to 564)
  AUTHORS   Huang,X., Li,Z., Shen,X., Nie,N. and Shen,Y.
  TITLE     IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in
            experimental autoimmune myocarditis
  JOURNAL   Cytokine 152, 155823 (2022)
   PUBMED   35183823
  REMARK    Erratum:[Cytokine. 2022 Jun;154:155879. doi:
            10.1016/j.cyto.2022.155879. PMID: 35413623]
REFERENCE   6  (residues 1 to 564)
  AUTHORS   Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
  TITLE     Identification of alternatively spliced Act1 and implications for
            its roles in oncogenesis
  JOURNAL   Biochem Biophys Res Commun 296 (2), 406-412 (2002)
   PUBMED   12163033
  REMARK    GeneRIF: Data indicate that the newly identified alternatively
            spliced Act1 is a major transcript of the molecule and that Act1
            may play important roles in oncogenesis.
REFERENCE   7  (residues 1 to 564)
  AUTHORS   Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
  TITLE     Role of NF kappa B activator Act1 in CD40-mediated signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9386-9391 (2002)
   PUBMED   12089335
  REMARK    GeneRIF: Endogenous Act1 is recruited to the CD40 receptor in human
            intestinal (HT29) and cervical (HeLa) epithelial cells upon
            stimulation with CD40 ligand, indicating that Act1 is involved in
            this signaling pathway.
REFERENCE   8  (residues 1 to 564)
  AUTHORS   Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and
            Siebenlist,U.
  TITLE     CIKS, a connection to Ikappa B kinase and stress-activated protein
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10494-10499 (2000)
   PUBMED   10962033
REFERENCE   9  (residues 1 to 564)
  AUTHORS   Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D.,
            Haag,M. and Stark,G.R.
  TITLE     Act1, an NF-kappa B-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10489-10493 (2000)
   PUBMED   10962024
REFERENCE   10 (residues 1 to 564)
  AUTHORS   Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and
            Barbanti-Brodano,G.
  TITLE     Cloning and characterization of two overlapping genes in a
            subregion at 6q21 involved in replicative senescence and
            schizophrenia
  JOURNAL   Gene 252 (1-2), 217-225 (2000)
   PUBMED   10903453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA836923.1, AK025351.1,
            AF136405.1, AL008730.1, AF136407.1, AW296296.1 and DA130363.1.
            
            Summary: This gene encodes a protein involved in regulating
            responses to cytokines by members of the Rel/NF-kappaB
            transcription factor family. These factors play a central role in
            innate immunity in response to pathogens, inflammatory signals and
            stress. This gene product interacts with TRAF proteins (tumor
            necrosis factor receptor-associated factors) and either I-kappaB
            kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
            Several alternative transcripts encoding different isoforms have
            been identified. Another transcript, which does not encode a
            protein and is transcribed in the opposite orientation, has been
            identified. Overexpression of this transcript has been shown to
            reduce expression of at least one of the protein encoding
            transcripts, suggesting it has a regulatory role in the expression
            of this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            acceptor splice site at an internal coding exon compared to variant
            2. This results in an isoform (3) that is 1 aa shorter than isoform
            2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025351.1, SRR14038192.2456427.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..564
                     /product="E3 ubiquitin ligase TRAF3IP2 isoform 3"
                     /EC_number="2.3.2.27"
                     /note="connection to IKK and SAPK/JNK; NFkB-activating
                     protein ACT1; adapter protein CIKS; nuclear factor
                     NF-kappa-B activator 1; E3 ubiquitin-protein ligase CIKS;
                     E3 ubiquitin ligase TRAF3IP2"
                     /calculated_mol_wt=63326
     Region          <224..387
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          401..542
                     /region_name="SEFIR"
                     /note="SEFIR domain; pfam08357"
                     /db_xref="CDD:254756"
     CDS             1..564
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /coded_by="NM_001164281.3:112..1806"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS55050.1"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
ORIGIN      
        1 mnrsipvevd esepypsqll kpipeyspee eseppapnir nmapnslsap tmlhnssgdf
       61 sqahstlkla nhqrpvsrqv tclrtqvled sedsfcrrhp glgkafpsgc savsepases
      121 vvgalpaehq fsfmekrnqw lvsqlsaasp dtghdsdksd qslpnasads lggsqemvqr
      181 pqphrnragl dlptidtgyd sqpqdvlgir qlerplplts vcypqdlprp lrsrefpqfe
      241 pqrypacaqm lppnlsphap wnyhyhcpgs pdhqvpyghd ypraayqqvi qpalpgqplp
      301 gasvrglhpv qkvilnypsp wdheerpaqr dcsfpglprh qdqphhqppn ragapgesle
      361 cpaelrpqvp qppspaavpr ppsnppargt lktsnlpeel rkvfitysmd tamevvkfvn
      421 fllvngfqta idifedrirg idiikwmery lrdtvmiiva ispkykqdve gaesqldede
      481 hglhtkyihr mmqiefikqg smnfrfipvl fpnakkehvp twlqnthvys wpknkknill
      541 rllreeeyva pprgplptlq vvpl
//
LOCUS       NP_001116434             342 aa            linear   PRI 27-AUG-2025
DEFINITION  signal-regulatory protein beta-2 isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_001116434 XP_001724827 XP_209363 XP_944990
VERSION     NP_001116434.1
DBSOURCE    REFSEQ: accession NM_001122962.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 342)
  AUTHORS   Song,Q., Qin,S., Pascal,L.E., Zou,C., Wang,W., Tong,H., Zhang,J.,
            Catalona,W.J., Dhir,R., Morrell,M., Balasubramani,G.K., Lu,Y. and
            Wang,Z.
  TITLE     SIRPB1 promotes prostate cancer cell proliferation via Akt
            activation
  JOURNAL   Prostate 80 (4), 352-364 (2020)
   PUBMED   31905248
  REMARK    GeneRIF: Results suggest that SIRPB1 is a potential oncogene
            capable of activating Akt signaling to stimulate prostate cancer
            proliferation and could be a biomarker for patients at risk of
            developing aggressive prostate cancer.
REFERENCE   2  (residues 1 to 342)
  AUTHORS   Reiner,A.P., Hartiala,J., Zeller,T., Bis,J.C., Dupuis,J.,
            Fornage,M., Baumert,J., Kleber,M.E., Wild,P.S., Baldus,S.,
            Bielinski,S.J., Fontes,J.D., Illig,T., Keating,B.J., Lange,L.A.,
            Ojeda,F., Muller-Nurasyid,M., Munzel,T.F., Psaty,B.M., Rice,K.,
            Rotter,J.I., Schnabel,R.B., Tang,W.H., Thorand,B., Erdmann,J.,
            Jacobs,D.R. Jr., Wilson,J.G., Koenig,W., Tracy,R.P.,
            Blankenberg,S., Marz,W., Gross,M.D., Benjamin,E.J., Hazen,S.L. and
            Allayee,H.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Genome-wide and gene-centric analyses of circulating
            myeloperoxidase levels in the charge and care consortia
  JOURNAL   Hum Mol Genet 22 (16), 3381-3393 (2013)
   PUBMED   23620142
REFERENCE   3  (residues 1 to 342)
  AUTHORS   Nyati,M.K., Feng,F.Y., Maheshwari,D., Varambally,S., Zielske,S.P.,
            Ahsan,A., Chun,P.Y., Arora,V.A., Davis,M.A., Jung,M., Ljungman,M.,
            Canman,C.E., Chinnaiyan,A.M. and Lawrence,T.S.
  TITLE     Ataxia telangiectasia mutated down-regulates phospho-extracellular
            signal-regulated kinase 1/2 via activation of MKP-1 in response to
            radiation
  JOURNAL   Cancer Res 66 (24), 11554-11559 (2006)
   PUBMED   17178844
  REMARK    GeneRIF: Relationship between ATM kinase and extracellular
            signal-regulated kinase 1/2 (ERK1/2), a key mitogenic stimulator.
REFERENCE   4  (residues 1 to 342)
  AUTHORS   Barclay,A.N. and Brown,M.H.
  TITLE     The SIRP family of receptors and immune regulation
  JOURNAL   Nat Rev Immunol 6 (6), 457-464 (2006)
   PUBMED   16691243
  REMARK    Review article
REFERENCE   5  (residues 1 to 342)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   6  (residues 1 to 342)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC313096.1, AK095499.1, AY424277.1, DC358609.1, BM285394.1,
            AL109658.5 and BG539998.1.
            
            On or before Apr 3, 2008 this sequence version replaced
            XP_209363.5, XP_944990.1, XP_001724827.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.132123.1,
                                           DRR138524.794375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359801.8/ ENSP00000352849.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     Protein         1..342
                     /product="signal-regulatory protein beta-2 isoform 1
                     precursor"
                     /note="protein tyrosine phosphatase, non-receptor type
                     substrate 1-like 3; SIRP-beta-2; protein tyrosine
                     phosphatase non-receptor type substrate protein"
                     /calculated_mol_wt=33726
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3260
     mat_peptide     33..342
                     /product="Signal-regulatory protein beta-2.
                     /id=PRO_0000338629"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5JXA9.1)"
                     /calculated_mol_wt=33726
     Region          40..150
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          56..60
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          70..74
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            116
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5JXA9.1)"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          142..145
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          161..264
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          176..180
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Site            179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5JXA9.1)"
     Region          190..194
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          225..229
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            231
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5JXA9.1)"
     Region          239..244
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          256..259
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            288..308
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5JXA9.1)"
     Region          317..342
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5JXA9.1)"
     CDS             1..342
                     /gene="SIRPB2"
                     /gene_synonym="dJ776F14.2; PTPN1L; PTPNS1L3"
                     /coded_by="NM_001122962.2:62..1090"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS42849.1"
                     /db_xref="GeneID:284759"
                     /db_xref="HGNC:HGNC:16247"
                     /db_xref="MIM:621323"
ORIGIN      
        1 mcstmsaptc lahlppcfll lalvlvpsda sgqssrndwq vlqpegpmlv aegetlllrc
       61 mvvgsctdgm ikwvkvstqd qqeiynfkrg sfpgvmpmiq rtseplncdy siyihnvtre
      121 htgtyhcvrf dglsehsemk sdegtsvlvk gagdpepdlw iiqpqelvlg ttgdtvflnc
      181 tvlgdgppgp irwfqgagls reaiynfggi shpketavqa snndfsillq nvssedagty
      241 ycvkfqrkpn rqylsgqgts lkvkakstss keaeftsepa temsptgllv vfapvvlglk
      301 aitlaallla latsrrspgq edvkttgpag amntlawskg qe
//
LOCUS       NP_001073272             952 aa            linear   PRI 27-AUG-2025
DEFINITION  lysosomal alpha-glucosidase preproprotein [Homo sapiens].
ACCESSION   NP_001073272
VERSION     NP_001073272.1
DBSOURCE    REFSEQ: accession NM_001079804.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Ruiz-Saavedra,S., Salazar,N., Suarez,A., Diaz,Y., Gonzalez Del
            Rey,C., Gonzalez,S. and de Los Reyes-Gavilan,C.G.
  TITLE     Human fecal alpha-glucosidase activity and its relationship with
            gut microbiota profiles and early stages of intestinal mucosa
            damage
  JOURNAL   Anaerobe 87, 102853 (2024)
   PUBMED   38614290
  REMARK    GeneRIF: Human fecal alpha-glucosidase activity and its
            relationship with gut microbiota profiles and early stages of
            intestinal mucosa damage.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wirth,T., Clement,G., Delvallee,C., Bonnet,C., Bogdan,T., Iosif,A.,
            Schalk,A., Chanson,J.B., Pellerin,D., Brais,B., Roth,V.,
            Wandzel,M., Fleury,M.C., Piton,A., Calmels,N., Namer,I.J.,
            Kremer,S., Tranchant,C., Renaud,M. and Anheim,M.
  TITLE     Natural History and Phenotypic Spectrum of GAA-FGF14 Sporadic
            Late-Onset Cerebellar Ataxia (SCA27B)
  JOURNAL   Mov Disord 38 (10), 1950-1956 (2023)
   PUBMED   37470282
  REMARK    GeneRIF: Natural History and Phenotypic Spectrum of GAA-FGF14
            Sporadic Late-Onset Cerebellar Ataxia (SCA27B).
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Chan,M.Y., Jalil,J.A., Yakob,Y., Wahab,S.A.A., Ali,E.Z.,
            Khalid,M.K.N.M., Leong,H.Y., Chew,H.B., Sivabalakrishnan,J.B. and
            Ngu,L.H.
  TITLE     Genotype, phenotype and treatment outcomes of 17 Malaysian patients
            with infantile-onset Pompe disease and the identification of 3
            novel GAA variants
  JOURNAL   Orphanet J Rare Dis 18 (1), 231 (2023)
   PUBMED   37542277
  REMARK    GeneRIF: Genotype, phenotype and treatment outcomes of 17 Malaysian
            patients with infantile-onset Pompe disease and the identification
            of 3 novel GAA variants.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Lim,J.A., Li,L. and Raben,N.
  TITLE     Pompe disease: from pathophysiology to therapy and back again
  JOURNAL   Front Aging Neurosci 6, 177 (2014)
   PUBMED   25183957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Moreland,R.J., Jin,X., Zhang,X.K., Decker,R.W., Albee,K.L.,
            Lee,K.L., Cauthron,R.D., Brewer,K., Edmunds,T. and Canfield,W.M.
  TITLE     Lysosomal acid alpha-glucosidase consists of four different
            peptides processed from a single chain precursor
  JOURNAL   J Biol Chem 280 (8), 6780-6791 (2005)
   PUBMED   15520017
  REMARK    GeneRIF: data show that the mature forms of GAA characterized by
            polypeptides of 76 or 70 kDa are in fact larger molecular mass
            multicomponent enzyme complexes; peptides released during
            proteolytic processing remained tightly associated with the major
            species
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sperry,E., Leslie,N., Berry,L. and Pena,L.
  TITLE     Pompe Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301438
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Martiniuk,F., Mehler,M., Bodkin,M., Tzall,S., Hirschhorn,K.,
            Zhong,N. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in an adult-onset patient
            with glycogenosis type II expressing only one allele
  JOURNAL   DNA Cell Biol 10 (9), 681-687 (1991)
   PUBMED   1684505
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Zhong,N., Martiniuk,F., Tzall,S. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in one allele of a patient
            with Pompe disease, and use of endonuclease digestion of
            PCR-amplified RNA to demonstrate lack of mRNA expression from the
            second allele
  JOURNAL   Am J Hum Genet 49 (3), 635-645 (1991)
   PUBMED   1652892
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Hermans,M.M., Kroos,M.A., van Beeumen,J., Oostra,B.A. and
            Reuser,A.J.
  TITLE     Human lysosomal alpha-glucosidase. Characterization of the
            catalytic site
  JOURNAL   J Biol Chem 266 (21), 13507-13512 (1991)
   PUBMED   1856189
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Hoefsloot,L.H., Hoogeveen-Westerveld,M., Kroos,M.A., van
            Beeumen,J., Reuser,A.J. and Oostra,B.A.
  TITLE     Primary structure and processing of lysosomal alpha-glucosidase;
            homology with the intestinal sucrase-isomaltase complex
  JOURNAL   EMBO J 7 (6), 1697-1704 (1988)
   PUBMED   3049072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC392486.1, BF206270.1,
            M34424.1, BQ711289.1, BC040431.1 and BF344248.1.
            
            Summary: This gene encodes lysosomal alpha-glucosidase, which is
            essential for the degradation of glycogen to glucose in lysosomes.
            The encoded preproprotein is proteolytically processed to generate
            multiple intermediate forms and the mature form of the enzyme.
            Defects in this gene are the cause of glycogen storage disease II,
            also known as Pompe's disease, which is an autosomal recessive
            disorder with a broad clinical spectrum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1771713.1,
                                           SRR1803613.175893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..952
                     /product="lysosomal alpha-glucosidase preproprotein"
                     /EC_number="3.2.1.20"
                     /note="lysosomal alpha-glucosidase; acid maltase;
                     aglucosidase alfa; glucosidase alpha, acid"
                     /calculated_mol_wt=102542
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=2800
     Region          47..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
     mat_peptide     70..952
                     /product="Lysosomal alpha-glucosidase. /id=PRO_0000018566"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=98009
     Region          81..132
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(95,125..126)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            order(111,125)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     mat_peptide     123..952
                     /product="76 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018567"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=92314
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Region          159..254
                     /region_name="NtCtMGAM_N"
                     /note="N-terminal barrel of NtMGAM and CtMGAM,
                     maltase-glucoamylase; pfam16863"
                     /db_xref="CDD:465286"
     mat_peptide     204..952
                     /product="70 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018568"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=82826
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Region          246..359
                     /region_name="GH31_N"
                     /note="N-terminal domain of glycosyl hydrolase family 31
                     (GH31); cd14752"
                     /db_xref="CDD:270212"
     Site            282
                     /site_type="active"
                     /db_xref="CDD:270212"
     Region          340..824
                     /region_name="Glyco_hydro_31"
                     /note="Glycosyl hydrolases family 31; pfam01055"
                     /db_xref="CDD:460044"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            470
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            652
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            882
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:8435067; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
     CDS             1..952
                     /gene="GAA"
                     /gene_synonym="IOPD; LOPD; LYAG"
                     /coded_by="NM_001079804.3:78..2936"
                     /db_xref="CCDS:CCDS32760.1"
                     /db_xref="GeneID:2548"
                     /db_xref="HGNC:HGNC:4065"
                     /db_xref="MIM:606800"
ORIGIN      
        1 mgvrhppcsh rllavcalvs lataallghi llhdfllvpr elsgsspvle ethpahqqga
       61 srpgprdaqa hpgrpravpt qcdvppnsrf dcapdkaitq eqceargccy ipakqglqga
      121 qmgqpwcffp psypsyklen lsssemgyta tltrttptff pkdiltlrld vmmetenrlh
      181 ftikdpanrr yevpletphv hsrapsplys vefseepfgv ivrrqldgrv llnttvaplf
      241 fadqflqlst slpsqyitgl aehlsplmls tswtritlwn rdlaptpgan lygshpfyla
      301 ledggsahgv fllnsnamdv vlqpspalsw rstggildvy iflgpepksv vqqyldvvgy
      361 pfmppywglg fhlcrwgyss taitrqvven mtrahfpldv qwndldymds rrdftfnkdg
      421 frdfpamvqe lhqggrrymm ivdpaisssg pagsyrpyde glrrgvfitn etgqpligkv
      481 wpgstafpdf tnptalawwe dmvaefhdqv pfdgmwidmn epsnfirgse dgcpnnelen
      541 ppyvpgvvgg tlqaaticas shqflsthyn lhnlygltea iashralvka rgtrpfvisr
      601 stfaghgrya ghwtgdvwss weqlassvpe ilqfnllgvp lvgadvcgfl gntseelcvr
      661 wtqlgafypf mrnhnsllsl pqepysfsep aqqamrkalt lryallphly tlfhqahvag
      721 etvarplfle fpkdsstwtv dhqllwgeal litpvlqagk aevtgyfplg twydlqtvpv
      781 ealgslpppp aaprepaihs egqwvtlpap ldtinvhlra gyiiplqgpg ltttesrqqp
      841 malavaltkg geargelfwd dgeslevler gaytqvifla rnntivnelv rvtsegaglq
      901 lqkvtvlgva tapqqvlsng vpvsnftysp dtkvldicvs llmgeqflvs wc
//
LOCUS       NP_848555                197 aa            linear   PRI 27-AUG-2025
DEFINITION  signal-regulatory protein delta isoform 1 precursor [Homo sapiens].
ACCESSION   NP_848555
VERSION     NP_848555.2
DBSOURCE    REFSEQ: accession NM_178460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 197)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   2  (residues 1 to 197)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049634.8, BC033502.1 and DA466740.1.
            
            On Sep 15, 2009 this sequence version replaced NP_848555.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.148972.1,
                                           SRR5189667.249750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381623.4/ ENSP00000371036.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     Protein         1..197
                     /product="signal-regulatory protein delta isoform 1
                     precursor"
                     /note="protein tyrosine phosphatase, non-receptor type
                     substrate 1-like 2; SIRP-delta"
                     /calculated_mol_wt=18602
     sig_peptide     1..29
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H106.2)"
                     /calculated_mol_wt=3103
     mat_peptide     30..197
                     /product="Signal-regulatory protein delta.
                     /id=PRO_0000014919"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H106.2)"
                     /calculated_mol_wt=18602
     Region          32..139
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          47..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409516"
     Region          61..65
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409516"
     Region          100..104
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409516"
     Region          114..119
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409516"
     Region          132..135
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409516"
     Region          139..158
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H106.2)"
     Site            174
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H106.2)"
     CDS             1..197
                     /gene="SIRPD"
                     /gene_synonym="dJ576H24.4; PTPNS1L2"
                     /coded_by="NM_178460.3:53..646"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS13018.1"
                     /db_xref="GeneID:128646"
                     /db_xref="HGNC:HGNC:16248"
                     /db_xref="MIM:621320"
ORIGIN      
        1 mpipasplhp plpslllyll lelagvthvf hvqqtemsqt vstgesiils csvpntlpng
       61 pvlwfkgtgp nrkliynfkq gnfprvkeig dttkpgntdf strireisla dagtyycvkf
      121 ikgraikeyq sgrgtqvfvt eqnprppknr pagragsrah hdahtclsal pernstnyfv
      181 qpccclrllg ltgllsk
//
LOCUS       NP_001393670             952 aa            linear   PRI 27-AUG-2025
DEFINITION  lysosomal alpha-glucosidase preproprotein [Homo sapiens].
ACCESSION   NP_001393670 XP_005257250
VERSION     NP_001393670.1
DBSOURCE    REFSEQ: accession NM_001406741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Ruiz-Saavedra,S., Salazar,N., Suarez,A., Diaz,Y., Gonzalez Del
            Rey,C., Gonzalez,S. and de Los Reyes-Gavilan,C.G.
  TITLE     Human fecal alpha-glucosidase activity and its relationship with
            gut microbiota profiles and early stages of intestinal mucosa
            damage
  JOURNAL   Anaerobe 87, 102853 (2024)
   PUBMED   38614290
  REMARK    GeneRIF: Human fecal alpha-glucosidase activity and its
            relationship with gut microbiota profiles and early stages of
            intestinal mucosa damage.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wirth,T., Clement,G., Delvallee,C., Bonnet,C., Bogdan,T., Iosif,A.,
            Schalk,A., Chanson,J.B., Pellerin,D., Brais,B., Roth,V.,
            Wandzel,M., Fleury,M.C., Piton,A., Calmels,N., Namer,I.J.,
            Kremer,S., Tranchant,C., Renaud,M. and Anheim,M.
  TITLE     Natural History and Phenotypic Spectrum of GAA-FGF14 Sporadic
            Late-Onset Cerebellar Ataxia (SCA27B)
  JOURNAL   Mov Disord 38 (10), 1950-1956 (2023)
   PUBMED   37470282
  REMARK    GeneRIF: Natural History and Phenotypic Spectrum of GAA-FGF14
            Sporadic Late-Onset Cerebellar Ataxia (SCA27B).
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Chan,M.Y., Jalil,J.A., Yakob,Y., Wahab,S.A.A., Ali,E.Z.,
            Khalid,M.K.N.M., Leong,H.Y., Chew,H.B., Sivabalakrishnan,J.B. and
            Ngu,L.H.
  TITLE     Genotype, phenotype and treatment outcomes of 17 Malaysian patients
            with infantile-onset Pompe disease and the identification of 3
            novel GAA variants
  JOURNAL   Orphanet J Rare Dis 18 (1), 231 (2023)
   PUBMED   37542277
  REMARK    GeneRIF: Genotype, phenotype and treatment outcomes of 17 Malaysian
            patients with infantile-onset Pompe disease and the identification
            of 3 novel GAA variants.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Lim,J.A., Li,L. and Raben,N.
  TITLE     Pompe disease: from pathophysiology to therapy and back again
  JOURNAL   Front Aging Neurosci 6, 177 (2014)
   PUBMED   25183957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Moreland,R.J., Jin,X., Zhang,X.K., Decker,R.W., Albee,K.L.,
            Lee,K.L., Cauthron,R.D., Brewer,K., Edmunds,T. and Canfield,W.M.
  TITLE     Lysosomal acid alpha-glucosidase consists of four different
            peptides processed from a single chain precursor
  JOURNAL   J Biol Chem 280 (8), 6780-6791 (2005)
   PUBMED   15520017
  REMARK    GeneRIF: data show that the mature forms of GAA characterized by
            polypeptides of 76 or 70 kDa are in fact larger molecular mass
            multicomponent enzyme complexes; peptides released during
            proteolytic processing remained tightly associated with the major
            species
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sperry,E., Leslie,N., Berry,L. and Pena,L.
  TITLE     Pompe Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301438
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Martiniuk,F., Mehler,M., Bodkin,M., Tzall,S., Hirschhorn,K.,
            Zhong,N. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in an adult-onset patient
            with glycogenosis type II expressing only one allele
  JOURNAL   DNA Cell Biol 10 (9), 681-687 (1991)
   PUBMED   1684505
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Zhong,N., Martiniuk,F., Tzall,S. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in one allele of a patient
            with Pompe disease, and use of endonuclease digestion of
            PCR-amplified RNA to demonstrate lack of mRNA expression from the
            second allele
  JOURNAL   Am J Hum Genet 49 (3), 635-645 (1991)
   PUBMED   1652892
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Hermans,M.M., Kroos,M.A., van Beeumen,J., Oostra,B.A. and
            Reuser,A.J.
  TITLE     Human lysosomal alpha-glucosidase. Characterization of the
            catalytic site
  JOURNAL   J Biol Chem 266 (21), 13507-13512 (1991)
   PUBMED   1856189
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Hoefsloot,L.H., Hoogeveen-Westerveld,M., Kroos,M.A., van
            Beeumen,J., Reuser,A.J. and Oostra,B.A.
  TITLE     Primary structure and processing of lysosomal alpha-glucosidase;
            homology with the intestinal sucrase-isomaltase complex
  JOURNAL   EMBO J 7 (6), 1697-1704 (1988)
   PUBMED   3049072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087741.18.
            
            On May 20, 2022 this sequence version replaced XP_005257250.1.
            
            Summary: This gene encodes lysosomal alpha-glucosidase, which is
            essential for the degradation of glycogen to glucose in lysosomes.
            The encoded preproprotein is proteolytically processed to generate
            multiple intermediate forms and the mature form of the enzyme.
            Defects in this gene are the cause of glycogen storage disease II,
            also known as Pompe's disease, which is an autosomal recessive
            disorder with a broad clinical spectrum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1381455.1,
                                           SRR14038191.2153984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..952
                     /product="lysosomal alpha-glucosidase preproprotein"
                     /EC_number="3.2.1.20"
                     /note="lysosomal alpha-glucosidase; acid maltase;
                     aglucosidase alfa; glucosidase alpha, acid"
                     /calculated_mol_wt=102542
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=2800
     Region          47..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
     mat_peptide     70..952
                     /product="Lysosomal alpha-glucosidase. /id=PRO_0000018566"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=98009
     Region          81..132
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(95,125..126)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            order(111,125)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     mat_peptide     123..952
                     /product="76 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018567"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=92314
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Region          159..254
                     /region_name="NtCtMGAM_N"
                     /note="N-terminal barrel of NtMGAM and CtMGAM,
                     maltase-glucoamylase; pfam16863"
                     /db_xref="CDD:465286"
     mat_peptide     204..952
                     /product="70 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018568"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=82826
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Region          246..359
                     /region_name="GH31_N"
                     /note="N-terminal domain of glycosyl hydrolase family 31
                     (GH31); cd14752"
                     /db_xref="CDD:270212"
     Site            282
                     /site_type="active"
                     /db_xref="CDD:270212"
     Region          340..824
                     /region_name="Glyco_hydro_31"
                     /note="Glycosyl hydrolases family 31; pfam01055"
                     /db_xref="CDD:460044"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            470
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            652
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            882
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:8435067; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
     CDS             1..952
                     /gene="GAA"
                     /gene_synonym="IOPD; LOPD; LYAG"
                     /coded_by="NM_001406741.1:253..3111"
                     /db_xref="CCDS:CCDS32760.1"
                     /db_xref="GeneID:2548"
                     /db_xref="HGNC:HGNC:4065"
                     /db_xref="MIM:606800"
ORIGIN      
        1 mgvrhppcsh rllavcalvs lataallghi llhdfllvpr elsgsspvle ethpahqqga
       61 srpgprdaqa hpgrpravpt qcdvppnsrf dcapdkaitq eqceargccy ipakqglqga
      121 qmgqpwcffp psypsyklen lsssemgyta tltrttptff pkdiltlrld vmmetenrlh
      181 ftikdpanrr yevpletphv hsrapsplys vefseepfgv ivrrqldgrv llnttvaplf
      241 fadqflqlst slpsqyitgl aehlsplmls tswtritlwn rdlaptpgan lygshpfyla
      301 ledggsahgv fllnsnamdv vlqpspalsw rstggildvy iflgpepksv vqqyldvvgy
      361 pfmppywglg fhlcrwgyss taitrqvven mtrahfpldv qwndldymds rrdftfnkdg
      421 frdfpamvqe lhqggrrymm ivdpaisssg pagsyrpyde glrrgvfitn etgqpligkv
      481 wpgstafpdf tnptalawwe dmvaefhdqv pfdgmwidmn epsnfirgse dgcpnnelen
      541 ppyvpgvvgg tlqaaticas shqflsthyn lhnlygltea iashralvka rgtrpfvisr
      601 stfaghgrya ghwtgdvwss weqlassvpe ilqfnllgvp lvgadvcgfl gntseelcvr
      661 wtqlgafypf mrnhnsllsl pqepysfsep aqqamrkalt lryallphly tlfhqahvag
      721 etvarplfle fpkdsstwtv dhqllwgeal litpvlqagk aevtgyfplg twydlqtvpv
      781 ealgslpppp aaprepaihs egqwvtlpap ldtinvhlra gyiiplqgpg ltttesrqqp
      841 malavaltkg geargelfwd dgeslevler gaytqvifla rnntivnelv rvtsegaglq
      901 lqkvtvlgva tapqqvlsng vpvsnftysp dtkvldicvs llmgeqflvs wc
//
LOCUS       NP_001268801             594 aa            linear   VRT 27-AUG-2025
DEFINITION  ceramide transfer protein isoform 2 [Danio rerio].
ACCESSION   NP_001268801 XP_005165586
VERSION     NP_001268801.2
DBSOURCE    REFSEQ: accession NM_001281872.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Casey,M.A., Hill,J.T., Hoshijima,K., Bryan,C.D., Gribble,S.L.,
            Brown,J.T., Chien,C.B., Yost,H.J. and Kwan,K.M.
  TITLE     Shutdown corner, a large deletion mutant isolated from a haploid
            mutagenesis screen in zebrafish
  JOURNAL   G3 (Bethesda) 12 (3) (2022)
   PUBMED   35079792
REFERENCE   2  (residues 1 to 594)
  AUTHORS   Simoes,F.C., Cahill,T.J., Kenyon,A., Gavriouchkina,D., Vieira,J.M.,
            Sun,X., Pezzolla,D., Ravaud,C., Masmanian,E., Weinberger,M.,
            Mayes,S., Lemieux,M.E., Barnette,D.N., Gunadasa-Rohling,M.,
            Williams,R.M., Greaves,D.R., Trinh,L.A., Fraser,S.E., Dallas,S.L.,
            Choudhury,R.P., Sauka-Spengler,T. and Riley,P.R.
  TITLE     Macrophages directly contribute collagen to scar formation during
            zebrafish heart regeneration and mouse heart repair
  JOURNAL   Nat Commun 11 (1), 600 (2020)
   PUBMED   32001677
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 594)
  AUTHORS   Burguera,D., Marquez,Y., Racioppi,C., Permanyer,J.,
            Torres-Mendez,A., Esposito,R., Albuixech-Crespo,B., Fanlo,L.,
            D'Agostino,Y., Gohr,A., Navas-Perez,E., Riesgo,A., Cuomo,C.,
            Benvenuto,G., Christiaen,L.A., Marti,E., D'Aniello,S.,
            Spagnuolo,A., Ristoratore,F., Arnone,M.I., Garcia-Fernandez,J. and
            Irimia,M.
  TITLE     Evolutionary recruitment of flexible Esrp-dependent splicing
            programs into diverse embryonic morphogenetic processes
  JOURNAL   Nat Commun 8 (1), 1799 (2017)
   PUBMED   29180615
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 594)
  AUTHORS   Granero-Molto,F., Sarmah,S., O'Rear,L., Spagnoli,A., Abrahamson,D.,
            Saus,J., Hudson,B.G. and Knapik,E.W.
  TITLE     Goodpasture antigen-binding protein and its spliced variant,
            ceramide transfer protein, have different functions in the
            modulation of apoptosis during zebrafish development
  JOURNAL   J Biol Chem 283 (29), 20495-20504 (2008)
   PUBMED   18424781
  REMARK    GeneRIF: study found both GPBP isoforms are expressed during early
            development &, when depleted, lead to apoptosis; results suggest
            GPBP is an important factor for normal skeletal muscle & brain
            development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000005.1.
            
            On Jun 25, 2025 this sequence version replaced NP_001268801.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01002733.1, GDQH01012356.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505388, SAMEA4476731
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     Protein         1..594
                     /product="ceramide transfer protein isoform 2"
                     /EC_number="2.7.11.1"
                     /note="cert; ceramide transfer protein; goodpasture
                     antigen-binding protein; collagen, type IV, alpha 3
                     (Goodpasture antigen) binding protein a; collagen type IV
                     alpha-3-binding protein"
                     /calculated_mol_wt=67467
     CDS             1..594
                     /gene="cert1a"
                     /gene_synonym="cert1; col4a3bp; col4a3bpa; wu:fc37f11;
                     zgc:92147"
                     /coded_by="NM_001281872.2:58..1842"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:796455"
                     /db_xref="ZFIN:ZDB-GENE-080724-10"
ORIGIN      
        1 msdcsssgsd edldpesell delggklskw tnyihgwqdr wialkgnils yyrsadekey
       61 gcrgsiclsk avitphefde crfdisvnds iwylraehpl lrqqwidtie lhkaesgygs
      121 esslrrhgsl lsltsaasgl stasassfkk ayslqeklae metfrdilcr qvdtlqkyfd
      181 ncadteskde lhrdkvsdee edfptlrpda dyllnnnnss keklfsvntl kdpagidfkg
      241 eaitfkatta gilstlshci dilvkreesw qkrldkeier rrraedayka altelkkkph
      301 yggpdyeegp nslineeeff daveaaldkh dqieeqsqve rsrasrqisl tpdtfssist
      361 qkyltkveem vhshmtyslq dvggdanwql vveegdmkvy rreveengiv ldplkathav
      421 kgvtghevch yfwdtayrnd wettvesfqv vetlsdqaci ihqtlkrvwp asqrdvlyvs
      481 vmrkilstne ndpdtwlvcn fsvdhdgypp strcirakin vamicqtlis ppegdkeisr
      541 dniickityv anvnpggwap asvlravakr eypkflkrft syvevktsse ailf
//
LOCUS       NP_671733                574 aa            linear   PRI 27-AUG-2025
DEFINITION  E3 ubiquitin ligase TRAF3IP2 isoform 1 [Homo sapiens].
ACCESSION   NP_671733
VERSION     NP_671733.2
DBSOURCE    REFSEQ: accession NM_147200.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 574)
  AUTHORS   Che,J., DePalma,T.J., Sivakumar,H., Mezache,L.S., Tallman,M.M.,
            Venere,M., Swindle-Reilly,K., Veeraraghavan,R. and Skardal,A.
  TITLE     alphaCT1 peptide sensitizes glioma cells to temozolomide in a
            glioblastoma organoid platform
  JOURNAL   Biotechnol Bioeng 120 (4), 1108-1119 (2023)
   PUBMED   36544242
  REMARK    GeneRIF: alphaCT1 peptide sensitizes glioma cells to temozolomide
            in a glioblastoma organoid platform.
REFERENCE   2  (residues 1 to 574)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 574)
  AUTHORS   Yan,Q. and Li,B.
  TITLE     TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation,
            migration, and extracellular matrix deposition in keloid through
            the TGF-beta1/Smad pathway
  JOURNAL   J Cosmet Dermatol 21 (10), 5148-5155 (2022)
   PUBMED   35441794
  REMARK    GeneRIF: TRAF3IP2 regulated by FOXO4 affects fibroblast
            proliferation, migration, and extracellular matrix deposition in
            keloid through the TGF-beta1/Smad pathway.
REFERENCE   4  (residues 1 to 574)
  AUTHORS   De Benedittis,G., Latini,A., Conigliaro,P., Triggianese,P.,
            Bergamini,A., Novelli,L., Ciccacci,C., Chimenti,M.S. and
            Borgiani,P.
  TITLE     A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients
  JOURNAL   Immunobiology 227 (4), 152232 (2022)
   PUBMED   35642993
  REMARK    GeneRIF: A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients.
REFERENCE   5  (residues 1 to 574)
  AUTHORS   Huang,X., Li,Z., Shen,X., Nie,N. and Shen,Y.
  TITLE     IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in
            experimental autoimmune myocarditis
  JOURNAL   Cytokine 152, 155823 (2022)
   PUBMED   35183823
  REMARK    Erratum:[Cytokine. 2022 Jun;154:155879. doi:
            10.1016/j.cyto.2022.155879. PMID: 35413623]
REFERENCE   6  (residues 1 to 574)
  AUTHORS   Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
  TITLE     Identification of alternatively spliced Act1 and implications for
            its roles in oncogenesis
  JOURNAL   Biochem Biophys Res Commun 296 (2), 406-412 (2002)
   PUBMED   12163033
  REMARK    GeneRIF: Data indicate that the newly identified alternatively
            spliced Act1 is a major transcript of the molecule and that Act1
            may play important roles in oncogenesis.
REFERENCE   7  (residues 1 to 574)
  AUTHORS   Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
  TITLE     Role of NF kappa B activator Act1 in CD40-mediated signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9386-9391 (2002)
   PUBMED   12089335
  REMARK    GeneRIF: Endogenous Act1 is recruited to the CD40 receptor in human
            intestinal (HT29) and cervical (HeLa) epithelial cells upon
            stimulation with CD40 ligand, indicating that Act1 is involved in
            this signaling pathway.
REFERENCE   8  (residues 1 to 574)
  AUTHORS   Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and
            Siebenlist,U.
  TITLE     CIKS, a connection to Ikappa B kinase and stress-activated protein
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10494-10499 (2000)
   PUBMED   10962033
REFERENCE   9  (residues 1 to 574)
  AUTHORS   Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D.,
            Haag,M. and Stark,G.R.
  TITLE     Act1, an NF-kappa B-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10489-10493 (2000)
   PUBMED   10962024
REFERENCE   10 (residues 1 to 574)
  AUTHORS   Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and
            Barbanti-Brodano,G.
  TITLE     Cloning and characterization of two overlapping genes in a
            subregion at 6q21 involved in replicative senescence and
            schizophrenia
  JOURNAL   Gene 252 (1-2), 217-225 (2000)
   PUBMED   10903453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA665549.1, AF136405.1,
            AK025351.1 and AL008730.1.
            
            On Apr 3, 2015 this sequence version replaced NP_671733.1.
            
            Summary: This gene encodes a protein involved in regulating
            responses to cytokines by members of the Rel/NF-kappaB
            transcription factor family. These factors play a central role in
            innate immunity in response to pathogens, inflammatory signals and
            stress. This gene product interacts with TRAF proteins (tumor
            necrosis factor receptor-associated factors) and either I-kappaB
            kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
            Several alternative transcripts encoding different isoforms have
            been identified. Another transcript, which does not encode a
            protein and is transcribed in the opposite orientation, has been
            identified. Overexpression of this transcript has been shown to
            reduce expression of at least one of the protein encoding
            transcripts, suggesting it has a regulatory role in the expression
            of this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) contains an alternate 5' exon
            which results in the use of an upstream in-frame start codon,
            compared to variant 2. The encoded isoform (1) has a longer
            N-terminus compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136405.1, SRR1660803.252821.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..574
                     /product="E3 ubiquitin ligase TRAF3IP2 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="connection to IKK and SAPK/JNK; NFkB-activating
                     protein ACT1; adapter protein CIKS; nuclear factor
                     NF-kappa-B activator 1; E3 ubiquitin-protein ligase CIKS;
                     E3 ubiquitin ligase TRAF3IP2"
                     /calculated_mol_wt=64535
     Region          1..256
                     /region_name="Mediates interaction with TRAF6.
                     /evidence=ECO:0000269|PubMed:12459498"
                     /note="propagated from UniProtKB/Swiss-Prot (O43734.3)"
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O43734.3)"
     Region          155..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O43734.3)"
     Region          <233..396
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          327..403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O43734.3)"
     Region          410..552
                     /region_name="SEFIR"
                     /note="SEFIR domain; pfam08357"
                     /db_xref="CDD:254756"
     CDS             1..574
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /coded_by="NM_147200.3:196..1920"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5092.1"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
ORIGIN      
        1 mppqlqetrm nrsipvevde sepypsqllk pipeyspeee seppapnirn mapnslsapt
       61 mlhnssgdfs qahstlklan hqrpvsrqvt clrtqvleds edsfcrrhpg lgkafpsgcs
      121 avsepasesv vgalpaehqf sfmekrnqwl vsqlsaaspd tghdsdksdq slpnasadsl
      181 ggsqemvqrp qphrnragld lptidtgyds qpqdvlgirq lerplpltsv cypqdlprpl
      241 rsrefpqfep qrypacaqml ppnlsphapw nyhyhcpgsp dhqvpyghdy praayqqviq
      301 palpgqplpg asvrglhpvq kvilnypspw dheerpaqrd csfpglprhq dqphhqppnr
      361 agapgeslec paelrpqvpq ppspaavprp psnppargtl ktsnlpeelr kvfitysmdt
      421 amevvkfvnf llvngfqtai difedrirgi diikwmeryl rdktvmiiva ispkykqdve
      481 gaesqldede hglhtkyihr mmqiefikqg smnfrfipvl fpnakkehvp twlqnthvys
      541 wpknkknill rllreeeyva pprgplptlq vvpl
//
LOCUS       NP_679211                565 aa            linear   PRI 27-AUG-2025
DEFINITION  E3 ubiquitin ligase TRAF3IP2 isoform 2 [Homo sapiens].
ACCESSION   NP_679211 NP_056339
VERSION     NP_679211.2
DBSOURCE    REFSEQ: accession NM_147686.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 565)
  AUTHORS   Che,J., DePalma,T.J., Sivakumar,H., Mezache,L.S., Tallman,M.M.,
            Venere,M., Swindle-Reilly,K., Veeraraghavan,R. and Skardal,A.
  TITLE     alphaCT1 peptide sensitizes glioma cells to temozolomide in a
            glioblastoma organoid platform
  JOURNAL   Biotechnol Bioeng 120 (4), 1108-1119 (2023)
   PUBMED   36544242
  REMARK    GeneRIF: alphaCT1 peptide sensitizes glioma cells to temozolomide
            in a glioblastoma organoid platform.
REFERENCE   2  (residues 1 to 565)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 565)
  AUTHORS   Yan,Q. and Li,B.
  TITLE     TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation,
            migration, and extracellular matrix deposition in keloid through
            the TGF-beta1/Smad pathway
  JOURNAL   J Cosmet Dermatol 21 (10), 5148-5155 (2022)
   PUBMED   35441794
  REMARK    GeneRIF: TRAF3IP2 regulated by FOXO4 affects fibroblast
            proliferation, migration, and extracellular matrix deposition in
            keloid through the TGF-beta1/Smad pathway.
REFERENCE   4  (residues 1 to 565)
  AUTHORS   De Benedittis,G., Latini,A., Conigliaro,P., Triggianese,P.,
            Bergamini,A., Novelli,L., Ciccacci,C., Chimenti,M.S. and
            Borgiani,P.
  TITLE     A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients
  JOURNAL   Immunobiology 227 (4), 152232 (2022)
   PUBMED   35642993
  REMARK    GeneRIF: A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients.
REFERENCE   5  (residues 1 to 565)
  AUTHORS   Huang,X., Li,Z., Shen,X., Nie,N. and Shen,Y.
  TITLE     IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in
            experimental autoimmune myocarditis
  JOURNAL   Cytokine 152, 155823 (2022)
   PUBMED   35183823
  REMARK    Erratum:[Cytokine. 2022 Jun;154:155879. doi:
            10.1016/j.cyto.2022.155879. PMID: 35413623]
REFERENCE   6  (residues 1 to 565)
  AUTHORS   Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
  TITLE     Identification of alternatively spliced Act1 and implications for
            its roles in oncogenesis
  JOURNAL   Biochem Biophys Res Commun 296 (2), 406-412 (2002)
   PUBMED   12163033
  REMARK    GeneRIF: Data indicate that the newly identified alternatively
            spliced Act1 is a major transcript of the molecule and that Act1
            may play important roles in oncogenesis.
REFERENCE   7  (residues 1 to 565)
  AUTHORS   Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
  TITLE     Role of NF kappa B activator Act1 in CD40-mediated signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9386-9391 (2002)
   PUBMED   12089335
  REMARK    GeneRIF: Endogenous Act1 is recruited to the CD40 receptor in human
            intestinal (HT29) and cervical (HeLa) epithelial cells upon
            stimulation with CD40 ligand, indicating that Act1 is involved in
            this signaling pathway.
REFERENCE   8  (residues 1 to 565)
  AUTHORS   Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and
            Siebenlist,U.
  TITLE     CIKS, a connection to Ikappa B kinase and stress-activated protein
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10494-10499 (2000)
   PUBMED   10962033
REFERENCE   9  (residues 1 to 565)
  AUTHORS   Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D.,
            Haag,M. and Stark,G.R.
  TITLE     Act1, an NF-kappa B-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10489-10493 (2000)
   PUBMED   10962024
REFERENCE   10 (residues 1 to 565)
  AUTHORS   Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and
            Barbanti-Brodano,G.
  TITLE     Cloning and characterization of two overlapping genes in a
            subregion at 6q21 involved in replicative senescence and
            schizophrenia
  JOURNAL   Gene 252 (1-2), 217-225 (2000)
   PUBMED   10903453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF136406.1, AF136405.1,
            AL008730.1, AF136407.1, AW296296.1 and DA130363.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 19, 2009 this sequence version replaced NP_679211.1.
            
            Summary: This gene encodes a protein involved in regulating
            responses to cytokines by members of the Rel/NF-kappaB
            transcription factor family. These factors play a central role in
            innate immunity in response to pathogens, inflammatory signals and
            stress. This gene product interacts with TRAF proteins (tumor
            necrosis factor receptor-associated factors) and either I-kappaB
            kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
            Several alternative transcripts encoding different isoforms have
            been identified. Another transcript, which does not encode a
            protein and is transcribed in the opposite orientation, has been
            identified. Overexpression of this transcript has been shown to
            reduce expression of at least one of the protein encoding
            transcripts, suggesting it has a regulatory role in the expression
            of this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (2) encodes isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136407.1, AF136406.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368761.11/ ENSP00000357750.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..565
                     /product="E3 ubiquitin ligase TRAF3IP2 isoform 2"
                     /EC_number="2.3.2.27"
                     /note="connection to IKK and SAPK/JNK; NFkB-activating
                     protein ACT1; adapter protein CIKS; nuclear factor
                     NF-kappa-B activator 1; E3 ubiquitin-protein ligase CIKS;
                     E3 ubiquitin ligase TRAF3IP2"
                     /calculated_mol_wt=63454
     Region          <224..387
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          401..543
                     /region_name="SEFIR"
                     /note="SEFIR domain; pfam08357"
                     /db_xref="CDD:254756"
     CDS             1..565
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /coded_by="NM_147686.4:112..1809"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS5093.1"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
ORIGIN      
        1 mnrsipvevd esepypsqll kpipeyspee eseppapnir nmapnslsap tmlhnssgdf
       61 sqahstlkla nhqrpvsrqv tclrtqvled sedsfcrrhp glgkafpsgc savsepases
      121 vvgalpaehq fsfmekrnqw lvsqlsaasp dtghdsdksd qslpnasads lggsqemvqr
      181 pqphrnragl dlptidtgyd sqpqdvlgir qlerplplts vcypqdlprp lrsrefpqfe
      241 pqrypacaqm lppnlsphap wnyhyhcpgs pdhqvpyghd ypraayqqvi qpalpgqplp
      301 gasvrglhpv qkvilnypsp wdheerpaqr dcsfpglprh qdqphhqppn ragapgesle
      361 cpaelrpqvp qppspaavpr ppsnppargt lktsnlpeel rkvfitysmd tamevvkfvn
      421 fllvngfqta idifedrirg idiikwmery lrdktvmiiv aispkykqdv egaesqlded
      481 ehglhtkyih rmmqiefikq gsmnfrfipv lfpnakkehv ptwlqnthvy swpknkknil
      541 lrllreeeyv apprgplptl qvvpl
//
LOCUS       NP_997006                724 aa            linear   PRI 27-AUG-2025
DEFINITION  GRB2-associated-binding protein 1 isoform a [Homo sapiens].
ACCESSION   NP_997006
VERSION     NP_997006.1
DBSOURCE    REFSEQ: accession NM_207123.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 724)
  AUTHORS   Nam,D.E., Park,S.J., Omole,S., Um,E., Hakami,R.M. and Hahn,Y.S.
  TITLE     Activated Gab1 drives hepatocyte proliferation and anti-apoptosis
            in liver fibrosis via potential involvement of the HGF/c-Met
            signaling axis
  JOURNAL   PLoS One 19 (6), e0306345 (2024)
   PUBMED   38935609
  REMARK    GeneRIF: Activated Gab1 drives hepatocyte proliferation and
            anti-apoptosis in liver fibrosis via potential involvement of the
            HGF/c-Met signaling axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 724)
  AUTHORS   Zhang,Y., Liu,J., Zhi,Y., You,X. and Wei,B.
  TITLE     Association of GAB1 gene with asthma susceptibility and the
            efficacy of inhaled corticosteroids in children
  JOURNAL   BMC Pulm Med 23 (1), 493 (2023)
   PUBMED   38057792
  REMARK    GeneRIF: Association of GAB1 gene with asthma susceptibility and
            the efficacy of inhaled corticosteroids in children.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 724)
  AUTHORS   Boetto,J., Bielle,F., Tran,S., Marijon,P., Peyre,M., Rigau,V. and
            Kalamarides,M.
  TITLE     GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma
  JOURNAL   Neurosurgery 92 (2), 391-397 (2023)
   PUBMED   36637273
  REMARK    GeneRIF: GAB1 as a Marker of Recurrence in Anterior Skull Base
            Meningioma.
REFERENCE   4  (residues 1 to 724)
  AUTHORS   Li,J., Yang,N., Tian,X., Ouyang,L., Jiang,M. and Zhang,S.
  TITLE     Interference of PTK6/GAB1 signaling inhibits cell proliferation,
            invasion, and migration of cervical cancer cells
  JOURNAL   Mol Med Rep 26 (3) (2022)
   PUBMED   35894144
  REMARK    GeneRIF: Interference of PTK6/GAB1 signaling inhibits cell
            proliferation, invasion, and migration of cervical cancer cells.
REFERENCE   5  (residues 1 to 724)
  AUTHORS   Chen,J., Kang,Z., Li,S., Wang,C., Zheng,X., Cai,Z., Pan,L., Chen,F.
            and Li,W.
  TITLE     Molecular profile reveals immune-associated markers of
            medulloblastoma for different subtypes
  JOURNAL   Front Immunol 13, 911260 (2022)
   PUBMED   35967388
  REMARK    GeneRIF: Molecular profile reveals immune-associated markers of
            medulloblastoma for different subtypes.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 724)
  AUTHORS   Holgado-Madruga,M., Moscatello,D.K., Emlet,D.R., Dieterich,R. and
            Wong,A.J.
  TITLE     Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase
            activation and the promotion of cell survival by nerve growth
            factor
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12419-12424 (1997)
   PUBMED   9356464
REFERENCE   7  (residues 1 to 724)
  AUTHORS   Nguyen,L., Holgado-Madruga,M., Maroun,C., Fixman,E.D., Kamikura,D.,
            Fournier,T., Charest,A., Tremblay,M.L., Wong,A.J. and Park,M.
  TITLE     Association of the multisubstrate docking protein Gab1 with the
            hepatocyte growth factor receptor requires a functional Grb2
            binding site involving tyrosine 1356
  JOURNAL   J Biol Chem 272 (33), 20811-20819 (1997)
   PUBMED   9252406
REFERENCE   8  (residues 1 to 724)
  AUTHORS   Fixman,E.D., Holgado-Madruga,M., Nguyen,L., Kamikura,D.M.,
            Fournier,T.M., Wong,A.J. and Park,M.
  TITLE     Efficient cellular transformation by the Met oncoprotein requires a
            functional Grb2 binding site and correlates with phosphorylation of
            the Grb2-associated proteins, Cbl and Gab1
  JOURNAL   J Biol Chem 272 (32), 20167-20172 (1997)
   PUBMED   9242692
REFERENCE   9  (residues 1 to 724)
  AUTHORS   Kanai,M., Goke,M., Tsunekawa,S. and Podolsky,D.K.
  TITLE     Signal transduction pathway of human fibroblast growth factor
            receptor 3. Identification of a novel 66-kDa phosphoprotein
  JOURNAL   J Biol Chem 272 (10), 6621-6628 (1997)
   PUBMED   9045692
REFERENCE   10 (residues 1 to 724)
  AUTHORS   Holgado-Madruga,M., Emlet,D.R., Moscatello,D.K., Godwin,A.K. and
            Wong,A.J.
  TITLE     A Grb2-associated docking protein in EGF- and insulin-receptor
            signalling
  JOURNAL   Nature 379 (6565), 560-564 (1996)
   PUBMED   8596638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA109618.1, BC064848.1,
            AK022142.1, DA249555.1, AC104685.2, BC030115.1 and AL049449.1.
            
            Summary: The protein encoded by this gene is a member of the
            IRS1-like multisubstrate docking protein family. It is an important
            mediator of branching tubulogenesis and plays a central role in
            cellular growth response, transformation and apoptosis. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.187448.1,
                                           SRR1803612.112025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     Protein         1..724
                     /product="GRB2-associated-binding protein 1 isoform a"
                     /note="GRB2-associated binder 1; growth factor receptor
                     bound protein 2-associated protein 1; deafness, autosomal
                     recessive 26"
                     /calculated_mol_wt=79874
     Region          3..125
                     /region_name="PH_Gab1_Gab2"
                     /note="Grb2-associated binding proteins 1 and 2 pleckstrin
                     homology (PH) domain; cd01266"
                     /db_xref="CDD:241297"
     CDS             1..724
                     /gene="GAB1"
                     /gene_synonym="DFNB26"
                     /coded_by="NM_207123.3:314..2488"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3760.1"
                     /db_xref="GeneID:2549"
                     /db_xref="HGNC:HGNC:4066"
                     /db_xref="MIM:604439"
ORIGIN      
        1 msggevvcsg wlrksppekk lkryawkrrw fvlrsgrltg dpdvleyykn dhakkpirii
       61 dlnlcqqvda gltfnkkefe nsyifdinti drifylvads eeemnkwvrc icdicgfnpt
      121 eedpvkppgs slqapadlpl aintappstq adsssatlpp pyqlinvpph letlgiqedp
      181 qdylllincq skkpeptrth adsakstsse tdcndnvpsh knpassqskh gmngffqqqm
      241 iydsppsrap sasvdsslyn lprsyshdvl pkvspsstea dgelyvfntp sgtssvetqm
      301 rhvsisydip ptpgntyqip rtfpegtlgq tskldtipdi ppprppkphp ahdrspvetc
      361 siprtasdtd ssyciptagm spsrsntist vdlnklrkda ssqdcydipr afpsdrsssl
      421 egfhnhfkvk nvltvgsvss eeldenyvpm npnspprqhs ssftepiqea nyvpmtpgtf
      481 dfssfgmqvp ppahmgfrss pktpprrpvp vadcepppvd rnlkpdrkgq spkilrlkph
      541 glertdsqti gdfatrrkvk papleikplp eweelqapvr spitrsfard ssrfpmsprp
      601 dsvhsttsss dshdseenyv pmnpnlssed pnlfgsnsld ggsspmikpk gdkqveyldl
      661 dldsgkstpp rkqkssgsgs svadervdyv vvdqqktlal kstreawtdg rqstesetpa
      721 ksvk
//
LOCUS       NP_001073271             952 aa            linear   PRI 27-AUG-2025
DEFINITION  lysosomal alpha-glucosidase preproprotein [Homo sapiens].
ACCESSION   NP_001073271
VERSION     NP_001073271.1
DBSOURCE    REFSEQ: accession NM_001079803.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Ruiz-Saavedra,S., Salazar,N., Suarez,A., Diaz,Y., Gonzalez Del
            Rey,C., Gonzalez,S. and de Los Reyes-Gavilan,C.G.
  TITLE     Human fecal alpha-glucosidase activity and its relationship with
            gut microbiota profiles and early stages of intestinal mucosa
            damage
  JOURNAL   Anaerobe 87, 102853 (2024)
   PUBMED   38614290
  REMARK    GeneRIF: Human fecal alpha-glucosidase activity and its
            relationship with gut microbiota profiles and early stages of
            intestinal mucosa damage.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wirth,T., Clement,G., Delvallee,C., Bonnet,C., Bogdan,T., Iosif,A.,
            Schalk,A., Chanson,J.B., Pellerin,D., Brais,B., Roth,V.,
            Wandzel,M., Fleury,M.C., Piton,A., Calmels,N., Namer,I.J.,
            Kremer,S., Tranchant,C., Renaud,M. and Anheim,M.
  TITLE     Natural History and Phenotypic Spectrum of GAA-FGF14 Sporadic
            Late-Onset Cerebellar Ataxia (SCA27B)
  JOURNAL   Mov Disord 38 (10), 1950-1956 (2023)
   PUBMED   37470282
  REMARK    GeneRIF: Natural History and Phenotypic Spectrum of GAA-FGF14
            Sporadic Late-Onset Cerebellar Ataxia (SCA27B).
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Chan,M.Y., Jalil,J.A., Yakob,Y., Wahab,S.A.A., Ali,E.Z.,
            Khalid,M.K.N.M., Leong,H.Y., Chew,H.B., Sivabalakrishnan,J.B. and
            Ngu,L.H.
  TITLE     Genotype, phenotype and treatment outcomes of 17 Malaysian patients
            with infantile-onset Pompe disease and the identification of 3
            novel GAA variants
  JOURNAL   Orphanet J Rare Dis 18 (1), 231 (2023)
   PUBMED   37542277
  REMARK    GeneRIF: Genotype, phenotype and treatment outcomes of 17 Malaysian
            patients with infantile-onset Pompe disease and the identification
            of 3 novel GAA variants.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Lim,J.A., Li,L. and Raben,N.
  TITLE     Pompe disease: from pathophysiology to therapy and back again
  JOURNAL   Front Aging Neurosci 6, 177 (2014)
   PUBMED   25183957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Moreland,R.J., Jin,X., Zhang,X.K., Decker,R.W., Albee,K.L.,
            Lee,K.L., Cauthron,R.D., Brewer,K., Edmunds,T. and Canfield,W.M.
  TITLE     Lysosomal acid alpha-glucosidase consists of four different
            peptides processed from a single chain precursor
  JOURNAL   J Biol Chem 280 (8), 6780-6791 (2005)
   PUBMED   15520017
  REMARK    GeneRIF: data show that the mature forms of GAA characterized by
            polypeptides of 76 or 70 kDa are in fact larger molecular mass
            multicomponent enzyme complexes; peptides released during
            proteolytic processing remained tightly associated with the major
            species
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sperry,E., Leslie,N., Berry,L. and Pena,L.
  TITLE     Pompe Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301438
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Martiniuk,F., Mehler,M., Bodkin,M., Tzall,S., Hirschhorn,K.,
            Zhong,N. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in an adult-onset patient
            with glycogenosis type II expressing only one allele
  JOURNAL   DNA Cell Biol 10 (9), 681-687 (1991)
   PUBMED   1684505
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Zhong,N., Martiniuk,F., Tzall,S. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in one allele of a patient
            with Pompe disease, and use of endonuclease digestion of
            PCR-amplified RNA to demonstrate lack of mRNA expression from the
            second allele
  JOURNAL   Am J Hum Genet 49 (3), 635-645 (1991)
   PUBMED   1652892
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Hermans,M.M., Kroos,M.A., van Beeumen,J., Oostra,B.A. and
            Reuser,A.J.
  TITLE     Human lysosomal alpha-glucosidase. Characterization of the
            catalytic site
  JOURNAL   J Biol Chem 266 (21), 13507-13512 (1991)
   PUBMED   1856189
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Hoefsloot,L.H., Hoogeveen-Westerveld,M., Kroos,M.A., van
            Beeumen,J., Reuser,A.J. and Oostra,B.A.
  TITLE     Primary structure and processing of lysosomal alpha-glucosidase;
            homology with the intestinal sucrase-isomaltase complex
  JOURNAL   EMBO J 7 (6), 1697-1704 (1988)
   PUBMED   3049072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY101855.1, BC040431.1,
            BF206270.1, M34424.1, BQ711289.1 and BF344248.1.
            
            Summary: This gene encodes lysosomal alpha-glucosidase, which is
            essential for the degradation of glycogen to glucose in lysosomes.
            The encoded preproprotein is proteolytically processed to generate
            multiple intermediate forms and the mature form of the enzyme.
            Defects in this gene are the cause of glycogen storage disease II,
            also known as Pompe's disease, which is an autosomal recessive
            disorder with a broad clinical spectrum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1783113.1,
                                           SRR7346977.1584163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..952
                     /product="lysosomal alpha-glucosidase preproprotein"
                     /EC_number="3.2.1.20"
                     /note="lysosomal alpha-glucosidase; acid maltase;
                     aglucosidase alfa; glucosidase alpha, acid"
                     /calculated_mol_wt=102542
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=2800
     Region          47..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
     mat_peptide     70..952
                     /product="Lysosomal alpha-glucosidase. /id=PRO_0000018566"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=98009
     Region          81..132
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(95,125..126)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            order(111,125)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     mat_peptide     123..952
                     /product="76 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018567"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=92314
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Region          159..254
                     /region_name="NtCtMGAM_N"
                     /note="N-terminal barrel of NtMGAM and CtMGAM,
                     maltase-glucoamylase; pfam16863"
                     /db_xref="CDD:465286"
     mat_peptide     204..952
                     /product="70 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018568"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=82826
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Region          246..359
                     /region_name="GH31_N"
                     /note="N-terminal domain of glycosyl hydrolase family 31
                     (GH31); cd14752"
                     /db_xref="CDD:270212"
     Site            282
                     /site_type="active"
                     /db_xref="CDD:270212"
     Region          340..824
                     /region_name="Glyco_hydro_31"
                     /note="Glycosyl hydrolases family 31; pfam01055"
                     /db_xref="CDD:460044"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            470
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            652
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            882
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:8435067; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
     CDS             1..952
                     /gene="GAA"
                     /gene_synonym="IOPD; LOPD; LYAG"
                     /coded_by="NM_001079803.3:158..3016"
                     /db_xref="CCDS:CCDS32760.1"
                     /db_xref="GeneID:2548"
                     /db_xref="HGNC:HGNC:4065"
                     /db_xref="MIM:606800"
ORIGIN      
        1 mgvrhppcsh rllavcalvs lataallghi llhdfllvpr elsgsspvle ethpahqqga
       61 srpgprdaqa hpgrpravpt qcdvppnsrf dcapdkaitq eqceargccy ipakqglqga
      121 qmgqpwcffp psypsyklen lsssemgyta tltrttptff pkdiltlrld vmmetenrlh
      181 ftikdpanrr yevpletphv hsrapsplys vefseepfgv ivrrqldgrv llnttvaplf
      241 fadqflqlst slpsqyitgl aehlsplmls tswtritlwn rdlaptpgan lygshpfyla
      301 ledggsahgv fllnsnamdv vlqpspalsw rstggildvy iflgpepksv vqqyldvvgy
      361 pfmppywglg fhlcrwgyss taitrqvven mtrahfpldv qwndldymds rrdftfnkdg
      421 frdfpamvqe lhqggrrymm ivdpaisssg pagsyrpyde glrrgvfitn etgqpligkv
      481 wpgstafpdf tnptalawwe dmvaefhdqv pfdgmwidmn epsnfirgse dgcpnnelen
      541 ppyvpgvvgg tlqaaticas shqflsthyn lhnlygltea iashralvka rgtrpfvisr
      601 stfaghgrya ghwtgdvwss weqlassvpe ilqfnllgvp lvgadvcgfl gntseelcvr
      661 wtqlgafypf mrnhnsllsl pqepysfsep aqqamrkalt lryallphly tlfhqahvag
      721 etvarplfle fpkdsstwtv dhqllwgeal litpvlqagk aevtgyfplg twydlqtvpv
      781 ealgslpppp aaprepaihs egqwvtlpap ldtinvhlra gyiiplqgpg ltttesrqqp
      841 malavaltkg geargelfwd dgeslevler gaytqvifla rnntivnelv rvtsegaglq
      901 lqkvtvlgva tapqqvlsng vpvsnftysp dtkvldicvs llmgeqflvs wc
//
LOCUS       NP_001428631             578 aa            linear   VRT 27-AUG-2025
DEFINITION  zinc finger protein 569 [Danio rerio].
ACCESSION   NP_001428631
VERSION     NP_001428631.1
DBSOURCE    REFSEQ: accession NM_001441702.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000004.1.
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     Protein         1..578
                     /product="zinc finger protein 569"
                     /calculated_mol_wt=66600
     CDS             1..578
                     /gene="si:ch73-120g24.5"
                     /coded_by="NM_001441702.1:111..1847"
                     /db_xref="GeneID:110437786"
                     /db_xref="ZFIN:ZDB-GENE-161017-9"
ORIGIN      
        1 malikeenee lrikeeneel rikeesegls itevftvkhe dpeeqtglmv lkeetrelne
       61 ieekdqcgkq fdlmtdepss vakntlceea ektkhfpchq cgksfsrkhg lnlhmrihtg
      121 ekpysctvcg ksfsaksgfn thmrihtgek pysctvcgks fteksrfnih mrihtgerpf
      181 sctvcgksfn ekkkleihmr ihtgekpysc tecgksfsek sklgmhmrih tgekpfacqh
      241 cgkrfsqmvs lkshfrvhtg ekphtcqqcg ksfaqkstlt ahiirhtgek pfpcdqcekr
      301 yvckhhlkrh krihakhkyf icdqcgssfk lkqnfdqhmk nhaeksficd qcgrncises
      361 gleshmkvht gekpysctec gkscshkhnl tvhmrvhtge kpfqchhcgk rfvtsyllks
      421 hmnfhtgkkp htcrpcgkrf vqysalkvhl rvhsgerpyt caqcgkgfaq khglyvhmrt
      481 htgekpftct qcgksftskk sqiihmrthh tgikpfacke cgrrfvckiy lnlhmkihte
      541 eitcfqsekr ftvrtrklhm akqacksghn nnpqdlpk
//
LOCUS       NP_001017914             620 aa            linear   VRT 27-AUG-2025
DEFINITION  ceramide transfer protein isoform 1 [Danio rerio].
ACCESSION   NP_001017914 XP_005165585
VERSION     NP_001017914.4
DBSOURCE    REFSEQ: accession NM_001017914.5
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 620)
  AUTHORS   Casey,M.A., Hill,J.T., Hoshijima,K., Bryan,C.D., Gribble,S.L.,
            Brown,J.T., Chien,C.B., Yost,H.J. and Kwan,K.M.
  TITLE     Shutdown corner, a large deletion mutant isolated from a haploid
            mutagenesis screen in zebrafish
  JOURNAL   G3 (Bethesda) 12 (3) (2022)
   PUBMED   35079792
REFERENCE   2  (residues 1 to 620)
  AUTHORS   Simoes,F.C., Cahill,T.J., Kenyon,A., Gavriouchkina,D., Vieira,J.M.,
            Sun,X., Pezzolla,D., Ravaud,C., Masmanian,E., Weinberger,M.,
            Mayes,S., Lemieux,M.E., Barnette,D.N., Gunadasa-Rohling,M.,
            Williams,R.M., Greaves,D.R., Trinh,L.A., Fraser,S.E., Dallas,S.L.,
            Choudhury,R.P., Sauka-Spengler,T. and Riley,P.R.
  TITLE     Macrophages directly contribute collagen to scar formation during
            zebrafish heart regeneration and mouse heart repair
  JOURNAL   Nat Commun 11 (1), 600 (2020)
   PUBMED   32001677
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 620)
  AUTHORS   Burguera,D., Marquez,Y., Racioppi,C., Permanyer,J.,
            Torres-Mendez,A., Esposito,R., Albuixech-Crespo,B., Fanlo,L.,
            D'Agostino,Y., Gohr,A., Navas-Perez,E., Riesgo,A., Cuomo,C.,
            Benvenuto,G., Christiaen,L.A., Marti,E., D'Aniello,S.,
            Spagnuolo,A., Ristoratore,F., Arnone,M.I., Garcia-Fernandez,J. and
            Irimia,M.
  TITLE     Evolutionary recruitment of flexible Esrp-dependent splicing
            programs into diverse embryonic morphogenetic processes
  JOURNAL   Nat Commun 8 (1), 1799 (2017)
   PUBMED   29180615
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 620)
  AUTHORS   Granero-Molto,F., Sarmah,S., O'Rear,L., Spagnoli,A., Abrahamson,D.,
            Saus,J., Hudson,B.G. and Knapik,E.W.
  TITLE     Goodpasture antigen-binding protein and its spliced variant,
            ceramide transfer protein, have different functions in the
            modulation of apoptosis during zebrafish development
  JOURNAL   J Biol Chem 283 (29), 20495-20504 (2008)
   PUBMED   18424781
  REMARK    GeneRIF: study found both GPBP isoforms are expressed during early
            development &, when depleted, lead to apoptosis; results suggest
            GPBP is an important factor for normal skeletal muscle & brain
            development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000005.1.
            
            On Jun 25, 2025 this sequence version replaced NP_001017914.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01004462.1,
                                           SRR26395064.1567181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505388, SAMEA4476731
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     Protein         1..620
                     /product="ceramide transfer protein isoform 1"
                     /EC_number="2.7.11.1"
                     /note="cert; ceramide transfer protein; goodpasture
                     antigen-binding protein; collagen, type IV, alpha 3
                     (Goodpasture antigen) binding protein a; collagen type IV
                     alpha-3-binding protein"
                     /calculated_mol_wt=70230
     Region          318..324
                     /region_name="FFAT.
                     /evidence=ECO:0000250|UniProtKB:Q9Y5P4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5M7Y0.2)"
     CDS             1..620
                     /gene="cert1a"
                     /gene_synonym="cert1; col4a3bp; col4a3bpa; wu:fc37f11;
                     zgc:92147"
                     /coded_by="NM_001017914.5:58..1920"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:796455"
                     /db_xref="ZFIN:ZDB-GENE-080724-10"
ORIGIN      
        1 msdcsssgsd edldpesell delggklskw tnyihgwqdr wialkgnils yyrsadekey
       61 gcrgsiclsk avitphefde crfdisvnds iwylraehpl lrqqwidtie lhkaesgygs
      121 esslrrhgsl lsltsaasgl stasassfkk ayslqeklae metfrdilcr qvdtlqkyfd
      181 ncadteskde lhrdkvsdee edfptlrpda dyllnnnnss keklfsvntl kdpagidfkg
      241 eaitfkatta gilstlshci dilvkreesw qkrldkeier rrraedayka altelkkkph
      301 yggpdyeegp nslineeeff daveaaldkh dqieeqsqve rsrasrqisl tpdtfssist
      361 qkyltkphsh tsslssvdli sasddvhrfs aqveemvhsh mtyslqdvgg danwqlvvee
      421 gdmkvyrrev eengivldpl kathavkgvt ghevchyfwd tayrndwett vesfqvvetl
      481 sdqaciihqt lkrvwpasqr dvlyvsvmrk ilstnendpd twlvcnfsvd hdgyppstrc
      541 irakinvami cqtlisppeg dkeisrdnii ckityvanvn pggwapasvl ravakreypk
      601 flkrftsyve vktsseailf
//
LOCUS       NP_001116789             813 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized protein LOC799483 isoform 2 [Danio rerio].
ACCESSION   NP_001116789 XP_001339833
VERSION     NP_001116789.1
DBSOURCE    REFSEQ: accession NM_001123317.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 813)
  AUTHORS   Postlethwait,J.H., Farnsworth,D.R. and Miller,A.C.
  TITLE     An intestinal cell type in zebrafish is the nexus for the
            SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System
            that contributes to COVID-19 comorbidities
  JOURNAL   bioRxiv (2020)
   PUBMED   32908984
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 813)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 813)
  AUTHORS   Seiler,C., Gebhart,N., Zhang,Y., Shinton,S.A., Li,Y.S., Ross,N.L.,
            Liu,X., Li,Q., Bilbee,A.N., Varshney,G.K., LaFave,M.C.,
            Burgess,S.M., Balciuniene,J., Balciunas,D., Hardy,R.R.,
            Kappes,D.J., Wiest,D.L. and Rhodes,J.
  TITLE     Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for
            T lymphocyte Development in Zebrafish
  JOURNAL   PLoS One 10 (7), e0131908 (2015)
   PUBMED   26161877
  REMARK    Publication Status: Online-Only
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            JBMGRA010000008.1.
            
            On Apr 11, 2008 this sequence version replaced XP_001339833.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA4476741, SAMEA4476748
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     Protein         1..813
                     /product="uncharacterized protein LOC799483 isoform 2"
                     /calculated_mol_wt=91280
     Region          116..240
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(135,185,189..190,193,196..197,234..235,238,245)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          278..543
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(311..313,326..327,329..331,333..334,337..338,341,
                     376,379..380,382..384,386..389,391..392,412,415,420..422,
                     425,465..467,470..472,474..476,478..481,496,500,535,
                     538..539)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          697..782
                     /region_name="RA_RalGDS"
                     /note="Ras-associating (RA) domain found in Ral guanine
                     nucleotide dissociation stimulator (RalGDS) and similar
                     proteins; cd17209"
                     /db_xref="CDD:340729"
     Site            order(697..700,702,709..717,721..722,730,733..734,736)
                     /site_type="other"
                     /note="RA-Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:340729"
     CDS             1..813
                     /gene="ralgds"
                     /gene_synonym="si:ch211-251j10.3"
                     /coded_by="NM_001123317.1:1..2442"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:799483"
                     /db_xref="ZFIN:ZDB-GENE-081105-110"
ORIGIN      
        1 mvyimgiqsd algvkptsld elfesstwri kniwdgvkle iaagdgcpvv lnsfthldpd
       61 lpmlessvqe igeevedgai ytitlrkvql hqtaskgqrw lgvetdsals lyetckgrti
      121 kagtleklve ymvsafkgkd ytyvtiflct yrafattkqv ldlllnryak lpasgktkvs
      181 aedhtelknt vssilgawld qysedfwspp dheclqslis ylqlnfsgsd lerralnlle
      241 hfqhrqqcev eiegdlcscp fatpeessle defspshfms fspsivaeql tvmdaelfkr
      301 vvpyhclggi wsqrdkkgke hlaptiratv sqfnsvtncv iatcldnrsl rpfqrakrie
      361 hwievarkcr ilksfsslka ilsalqsnai hrlrrawddv sresyrtfqe lseifsddnn
      421 yslsrellik egtsksaive inhkgaqrrh qqqrdmgvvq gtipylgtfl tdlvmldtam
      481 kdhlevglin fekrrkefev iaqikllqlt cnyynfsrnq rfidwfkrve kltetesysm
      541 scdieppses lckknggimk rmseesgyss aashsksfeq prlsqfkdcf kdgadslslt
      601 sagssgsdad eslsllnspe sgsqrlwesp tpssleasgs glclesgcss stssssssss
      661 svsaftgrtf nfhkrsvsgi sdysslslpl ynqqandcci irvsldseng nmyksilvts
      721 qdktpgvirk amakhnldnd ksedyellqr vskhkelrip dngnvfyamn stanydfllr
      781 krgvpktcrs ksspsltlpr mkqkgfkipk sff
//
LOCUS       NP_001429469             837 aa            linear   VRT 27-AUG-2025
DEFINITION  uncharacterized protein LOC799483 isoform 1 [Danio rerio].
ACCESSION   NP_001429469 XP_005167239
VERSION     NP_001429469.1
DBSOURCE    REFSEQ: accession NM_001442540.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 837)
  AUTHORS   Postlethwait,J.H., Farnsworth,D.R. and Miller,A.C.
  TITLE     An intestinal cell type in zebrafish is the nexus for the
            SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System
            that contributes to COVID-19 comorbidities
  JOURNAL   bioRxiv (2020)
   PUBMED   32908984
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 837)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 837)
  AUTHORS   Seiler,C., Gebhart,N., Zhang,Y., Shinton,S.A., Li,Y.S., Ross,N.L.,
            Liu,X., Li,Q., Bilbee,A.N., Varshney,G.K., LaFave,M.C.,
            Burgess,S.M., Balciuniene,J., Balciunas,D., Hardy,R.R.,
            Kappes,D.J., Wiest,D.L. and Rhodes,J.
  TITLE     Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for
            T lymphocyte Development in Zebrafish
  JOURNAL   PLoS One 10 (7), e0131908 (2015)
   PUBMED   26161877
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000008.1.
            
            On Aug 12, 2025 this sequence version replaced XP_005167239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GDQH01010370.1,
                                           SRR32588715.2745457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     Protein         1..837
                     /product="uncharacterized protein LOC799483 isoform 1"
                     /calculated_mol_wt=93726
     CDS             1..837
                     /gene="ralgds"
                     /gene_synonym="si:ch211-251j10.3"
                     /coded_by="NM_001442540.1:88..2601"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:799483"
                     /db_xref="ZFIN:ZDB-GENE-081105-110"
ORIGIN      
        1 mvyimgiqsd algvkptsld elfesstwri kniwdgvkle iaagdgcpvv lnsfthldpd
       61 lpmlessvqe igeevedgai ytitlrkvql hqtaskgqrw lgvetdsals lyetckgrti
      121 kagtleklve ymvsafkgkd ytyvtiflct yrafattkqv ldlllnryak lpasgktkvs
      181 aedhtelknt vssilgawld qysedfwspp dheclqslis ylqlnfsgsd lerralnlle
      241 hfqhrqqcev eiegdlcscp fatpeessle defspshfms fspsivaeql tvmdaelfkr
      301 vvpyhclggi wsqrdkkgke hlaptiratv sqfnsvtncv iatcldnrsl rpfqrakrie
      361 hwievarkcr ilksfsslka ilsalqsnai hrlrrawddv sresyrtfqe lseifsddnn
      421 yslsrellik egtsksaive inhkgaqrrh qqqrdmgvvq gtipylgtfl tdlvmldtam
      481 kdhlevglin fekrrkefev iaqikllqlt cnyynfsrnq rfidwfkrve kltetesysm
      541 scdieppses lckknggimk rmseesgyss aashsksfeq prlsqfkdcf kdgadslslt
      601 sagssgsdad eslsllnspe sgsqrtstpt vkhsstsetg elpsdsstkl wesptpssle
      661 asgsglcles gcssstssss sssssvsaft grtfnfhkrs vsgisdyssl slplynqqan
      721 dcciirvsld sengnmyksi lvtsqdktpg virkamakhn ldndksedye llqrvskhke
      781 lripdngnvf yamnstanyd fllrkrgvpk tcrsksspsl tlprmkqkgf kipksff
//
LOCUS       NP_001373194             211 aa            linear   VRT 27-AUG-2025
DEFINITION  complement C1q like 1 precursor [Danio rerio].
ACCESSION   NP_001373194 XP_699016
VERSION     NP_001373194.1
DBSOURCE    REFSEQ: accession NM_001386265.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 211)
  AUTHORS   Farr,D., Nag,D., Chazin,W.J., Harrison,S., Thummel,R., Luo,X.,
            Raychaudhuri,S. and Withey,J.H.
  TITLE     Neutrophil-Associated Responses to Vibrio cholerae Infection in a
            Natural Host Model
  JOURNAL   Infect Immun 90 (3), e0046621 (2022)
   PUBMED   35072520
REFERENCE   2  (residues 1 to 211)
  AUTHORS   Earley,A.M., Graves,C.L. and Shiau,C.E.
  TITLE     Critical Role for a Subset of Intestinal Macrophages in Shaping Gut
            Microbiota in Adult Zebrafish
  JOURNAL   Cell Rep 25 (2), 424-436 (2018)
   PUBMED   30304682
REFERENCE   3  (residues 1 to 211)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 211)
  AUTHORS   Hu,Y.L., Pan,X.M., Xiang,L.X. and Shao,J.Z.
  TITLE     Characterization of C1q in teleosts: insight into the molecular and
            functional evolution of C1q family and classical pathway
  JOURNAL   J Biol Chem 285 (37), 28777-28786 (2010)
   PUBMED   20615881
REFERENCE   5  (residues 1 to 211)
  AUTHORS   Sie,C.P. and Maas,S.
  TITLE     Conserved recoding RNA editing of vertebrate C1q-related factor
            C1QL1
  JOURNAL   FEBS Lett 583 (7), 1171-1174 (2009)
   PUBMED   19275900
  REMARK    GeneRIF: Conserved recoding RNA editing of vertebrate C1q-related
            factor C1QL1.
REFERENCE   6  (residues 1 to 211)
  AUTHORS   Mei,J. and Gui,J.
  TITLE     Bioinformatic identification of genes encoding
            C1q-domain-containing proteins in zebrafish
  JOURNAL   J Genet Genomics 35 (1), 17-24 (2008)
   PUBMED   18222405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000020.1.
            
            On Aug 15, 2020 this sequence version replaced XP_699016.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01037591.1, EH472747.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505381, SAMEA4476746
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     Protein         1..211
                     /product="complement C1q like 1 precursor"
                     /note="C1ql3; complement component 1, q subcomponent-like
                     1"
                     /calculated_mol_wt=19999
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2039
     Region          87..208
                     /region_name="C1q"
                     /note="C1q domain; pfam00386"
                     /db_xref="CDD:395310"
     CDS             1..211
                     /gene="c1ql1"
                     /gene_synonym="si:dkey-5n18.1"
                     /coded_by="NM_001386265.2:68..703"
                     /db_xref="GeneID:570444"
                     /db_xref="ZFIN:ZDB-GENE-041014-144"
ORIGIN      
        1 mahrwtavll tllslsraqv seapsgscri vcdpssdrpv drsnglvipl sssaagapgp
       61 vgppgkagpp gppgpsglgs tskggvafsa vlqdsfsqnv vlkfkdvitn igsaydassg
      121 tftcktagvy yfsfhivktg qnlrvdmlln dksvvsavav dllhtdtasn svvlqlkagd
      181 riylqlnnsd lgkrdsqsrl ssfsgyllye i
//
LOCUS       NP_001076498             335 aa            linear   VRT 27-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 [Danio rerio].
ACCESSION   NP_001076498
VERSION     NP_001076498.2
DBSOURCE    REFSEQ: accession NM_001083029.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 335)
  AUTHORS   Yamakawa,N., Vanbeselaere,J., Chang,L.Y., Yu,S.Y., Ducrocq,L.,
            Harduin-Lepers,A., Kurata,J., Aoki-Kinoshita,K.F., Sato,C.,
            Khoo,K.H., Kitajima,K. and Guerardel,Y.
  TITLE     Systems glycomics of adult zebrafish identifies organ-specific
            sialylation and glycosylation patterns
  JOURNAL   Nat Commun 9 (1), 4647 (2018)
   PUBMED   30405127
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 335)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 335)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 335)
  AUTHORS   Petit,D., Teppa,E., Mir,A.M., Vicogne,D., Thisse,C., Thisse,B.,
            Filloux,C. and Harduin-Lepers,A.
  TITLE     Integrative view of alpha2,3-sialyltransferases (ST3Gal) molecular
            and functional evolution in deuterostomes: significance of
            lineage-specific losses
  JOURNAL   Mol Biol Evol 32 (4), 906-927 (2015)
   PUBMED   25534026
REFERENCE   5  (residues 1 to 335)
  AUTHORS   Briolat,V., Jouneau,L., Carvalho,R., Palha,N., Langevin,C.,
            Herbomel,P., Schwartz,O., Spaink,H.P., Levraud,J.P. and Boudinot,P.
  TITLE     Contrasted innate responses to two viruses in zebrafish: insights
            into the ancestral repertoire of vertebrate IFN-stimulated genes
  JOURNAL   J Immunol 192 (9), 4328-4341 (2014)
   PUBMED   24683187
REFERENCE   6  (residues 1 to 335)
  AUTHORS   Cannon,J.E., Place,E.S., Eve,A.M., Bradshaw,C.R., Sesay,A.,
            Morrell,N.W. and Smith,J.C.
  TITLE     Global analysis of the haematopoietic and endothelial transcriptome
            during zebrafish development
  JOURNAL   Mech Dev 130 (2-3), 122-131 (2013)
   PUBMED   23072875
REFERENCE   7  (residues 1 to 335)
  AUTHORS   Vanbeselaere,J., Chang,L.Y., Harduin-Lepers,A., Fabre,E.,
            Yamakawa,N., Slomianny,C., Biot,C., Khoo,K.H. and Guerardel,Y.
  TITLE     Mapping the expressed glycome and glycosyltransferases of zebrafish
            liver cells as a relevant model system for glycosylation studies
  JOURNAL   J Proteome Res 11 (4), 2164-2177 (2012)
   PUBMED   22352757
REFERENCE   8  (residues 1 to 335)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000018.1.
            
            On Jul 28, 2025 this sequence version replaced NP_001076498.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GDQH01010064.1,
                                           SRR32588730.17124171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     Protein         1..335
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4"
                     /EC_number="2.4.3.4"
                     /calculated_mol_wt=38463
     CDS             1..335
                     /gene="st3gal4"
                     /gene_synonym="im:7151092; siat4c; zgc:158162"
                     /coded_by="NM_001083029.2:345..1352"
                     /db_xref="GeneID:504044"
                     /db_xref="ZFIN:ZDB-GENE-050309-174"
ORIGIN      
        1 mtlkatktwf lrllpvvlff icyycsqfyf essggksphp tlalcpnyrl qkkwenlnln
       61 msrkpdlflk ledffwkdhl saealpygik gsellllkvl aaissftmpa niesldcrtc
      121 avigngfalk nsslgeiink ydvvirlnda pvrgfeedvg nkttlrlfyp esasynpgih
      181 ndpdtllvlv pfkqqdlrwl keilydekrv qkgfwkpppq iwlgrasqir vldpyflrit
      241 arkflqipvq prkqqkavhp ttgllavfva lnycdvvhva gfgypasrnq nqpihyygqq
      301 tmksmknsyh dlnqeaqilh rleeqgvily lhphs
//
LOCUS       NP_001268924             235 aa            linear   VRT 27-AUG-2025
DEFINITION  tumor necrosis factor ligand superfamily member 14 [Danio rerio].
ACCESSION   NP_001268924 XP_001338573
VERSION     NP_001268924.1
DBSOURCE    REFSEQ: accession NM_001281995.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 235)
  AUTHORS   Cao,M., Wang,N., Yan,X., Yang,N., Fu,Q., Zhang,X., Zhang,Y. and
            Li,C.
  TITLE     Structures, evolutionary relationships and expression profiles of
            the tumour necrosis factor superfamily and their receptors in black
            rockfish (Sebastes schlegelii)
  JOURNAL   Dev Comp Immunol 132, 104405 (2022)
   PUBMED   35364135
REFERENCE   2  (residues 1 to 235)
  AUTHORS   Ko,S., Lim,J. and Hong,S.
  TITLE     Functional characterization of a novel tumor necrosis factor gene
            (TNF-New) in rock bream (Oplegnathus fasciatus)
  JOURNAL   Dev Comp Immunol 127, 104269 (2022)
   PUBMED   34600021
REFERENCE   3  (residues 1 to 235)
  AUTHORS   Shi,W., Shao,T., Li,J.Y., Fan,D.D., Lin,A.F., Xiang,L.X. and
            Shao,J.Z.
  TITLE     BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and
            Inflammation in a ConA-Induced Hepatitis Model in Zebrafish
  JOURNAL   J Immunol 203 (9), 2425-2442 (2019)
   PUBMED   31562209
REFERENCE   4  (residues 1 to 235)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 235)
  AUTHORS   Biswas,G., Kinoshita,S., Kono,T., Hikima,J. and Sakai,M.
  TITLE     Evolutionary evidence of tumor necrosis factor super family members
            in the Japanese pufferfish (Takifugu rubripes): Comprehensive
            genomic identification and expression analysis
  JOURNAL   Mar Genomics 22, 25-36 (2015)
   PUBMED   25792259
REFERENCE   6  (residues 1 to 235)
  AUTHORS   Tian,A.Y., Yang,H.J., Zhu,S.C., Zhang,Y.S., Jiang,Z.A., Song,J.Y.,
            Liu,H.Z. and Zhang,S.Q.
  TITLE     Isolation and characterization of LIGHT (TNFSF14) gene homologue in
            zebrafish (Danio rerio)
  JOURNAL   Int Immunopharmacol 14 (4), 629-634 (2012)
   PUBMED   23041296
  REMARK    GeneRIF: The isolation and characterization of TNFSF14 protein are
            reported.
REFERENCE   7  (residues 1 to 235)
  AUTHORS   Poulton,L.D., Nolan,K.F., Anastasaki,C., Waldmann,H. and
            Patton,E.E.
  TITLE     A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl)
            in early embryonic zebrafish development
  JOURNAL   Int J Dev Biol 54 (5), 815-825 (2010)
   PUBMED   19598108
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JX023464.1.
            
            On Aug 31, 2013 this sequence version replaced XP_001338573.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX023464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476765, SAMEA4476774
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..235
                     /product="tumor necrosis factor ligand superfamily member
                     14"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     14"
                     /calculated_mol_wt=26645
     Region          118..235
                     /region_name="TNF"
                     /note="Tumor Necrosis Factor; TNF superfamily members
                     include the cytokines: TNF (TNF-alpha), LT
                     (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
                     Fas ligand, and osteoprotegerin (OPG) ligand. These
                     proteins generally have an intracellular N-terminal...;
                     cl00147"
                     /db_xref="CDD:444713"
     Site            order(119,122,127,162,169,175)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     Site            order(147,149,198,203,229,233)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     CDS             1..235
                     /gene="tnfsf14"
                     /gene_synonym="light"
                     /coded_by="NM_001281995.1:1..708"
                     /db_xref="GeneID:798119"
                     /db_xref="ZFIN:ZDB-GENE-101109-3"
ORIGIN      
        1 masgnvsyps vfvvdghmrp pplppkpasr hrkeaiqtll filvtlalfg maveacfiyr
       61 lysvketiir tdeshtamsk qdkvvaepkk nrlgemkpsk pmgqlttglr vnnevvlwhe
      121 nhdsilhfik hksqegklii ekegfysvys kinykeesil fthsvvrntq rfageeilll
      181 qssslhpkip rpsiensfln gvfhlykdda ifvrvkncti vlsnsaenyf glfmi
//
LOCUS       NP_001157755             109 aa            linear   PRI 27-AUG-2025
DEFINITION  E3 ubiquitin ligase TRAF3IP2 isoform 5 [Homo sapiens].
ACCESSION   NP_001157755
VERSION     NP_001157755.1
DBSOURCE    REFSEQ: accession NM_001164283.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 109)
  AUTHORS   Che,J., DePalma,T.J., Sivakumar,H., Mezache,L.S., Tallman,M.M.,
            Venere,M., Swindle-Reilly,K., Veeraraghavan,R. and Skardal,A.
  TITLE     alphaCT1 peptide sensitizes glioma cells to temozolomide in a
            glioblastoma organoid platform
  JOURNAL   Biotechnol Bioeng 120 (4), 1108-1119 (2023)
   PUBMED   36544242
  REMARK    GeneRIF: alphaCT1 peptide sensitizes glioma cells to temozolomide
            in a glioblastoma organoid platform.
REFERENCE   2  (residues 1 to 109)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 109)
  AUTHORS   Yan,Q. and Li,B.
  TITLE     TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation,
            migration, and extracellular matrix deposition in keloid through
            the TGF-beta1/Smad pathway
  JOURNAL   J Cosmet Dermatol 21 (10), 5148-5155 (2022)
   PUBMED   35441794
  REMARK    GeneRIF: TRAF3IP2 regulated by FOXO4 affects fibroblast
            proliferation, migration, and extracellular matrix deposition in
            keloid through the TGF-beta1/Smad pathway.
REFERENCE   4  (residues 1 to 109)
  AUTHORS   De Benedittis,G., Latini,A., Conigliaro,P., Triggianese,P.,
            Bergamini,A., Novelli,L., Ciccacci,C., Chimenti,M.S. and
            Borgiani,P.
  TITLE     A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients
  JOURNAL   Immunobiology 227 (4), 152232 (2022)
   PUBMED   35642993
  REMARK    GeneRIF: A multilocus genetic study evidences the association of
            autoimmune-related genes with Psoriatic Arthritis in Italian
            patients.
REFERENCE   5  (residues 1 to 109)
  AUTHORS   Huang,X., Li,Z., Shen,X., Nie,N. and Shen,Y.
  TITLE     IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in
            experimental autoimmune myocarditis
  JOURNAL   Cytokine 152, 155823 (2022)
   PUBMED   35183823
  REMARK    Erratum:[Cytokine. 2022 Jun;154:155879. doi:
            10.1016/j.cyto.2022.155879. PMID: 35413623]
REFERENCE   6  (residues 1 to 109)
  AUTHORS   Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
  TITLE     Identification of alternatively spliced Act1 and implications for
            its roles in oncogenesis
  JOURNAL   Biochem Biophys Res Commun 296 (2), 406-412 (2002)
   PUBMED   12163033
  REMARK    GeneRIF: Data indicate that the newly identified alternatively
            spliced Act1 is a major transcript of the molecule and that Act1
            may play important roles in oncogenesis.
REFERENCE   7  (residues 1 to 109)
  AUTHORS   Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
  TITLE     Role of NF kappa B activator Act1 in CD40-mediated signaling in
            epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9386-9391 (2002)
   PUBMED   12089335
  REMARK    GeneRIF: Endogenous Act1 is recruited to the CD40 receptor in human
            intestinal (HT29) and cervical (HeLa) epithelial cells upon
            stimulation with CD40 ligand, indicating that Act1 is involved in
            this signaling pathway.
REFERENCE   8  (residues 1 to 109)
  AUTHORS   Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and
            Siebenlist,U.
  TITLE     CIKS, a connection to Ikappa B kinase and stress-activated protein
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10494-10499 (2000)
   PUBMED   10962033
REFERENCE   9  (residues 1 to 109)
  AUTHORS   Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D.,
            Haag,M. and Stark,G.R.
  TITLE     Act1, an NF-kappa B-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10489-10493 (2000)
   PUBMED   10962024
REFERENCE   10 (residues 1 to 109)
  AUTHORS   Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and
            Barbanti-Brodano,G.
  TITLE     Cloning and characterization of two overlapping genes in a
            subregion at 6q21 involved in replicative senescence and
            schizophrenia
  JOURNAL   Gene 252 (1-2), 217-225 (2000)
   PUBMED   10903453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB049654.1, AF136405.1,
            AL008730.1, AF136407.1, AW296296.1 and DA130363.1.
            
            Summary: This gene encodes a protein involved in regulating
            responses to cytokines by members of the Rel/NF-kappaB
            transcription factor family. These factors play a central role in
            innate immunity in response to pathogens, inflammatory signals and
            stress. This gene product interacts with TRAF proteins (tumor
            necrosis factor receptor-associated factors) and either I-kappaB
            kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
            Several alternative transcripts encoding different isoforms have
            been identified. Another transcript, which does not encode a
            protein and is transcribed in the opposite orientation, has been
            identified. Overexpression of this transcript has been shown to
            reduce expression of at least one of the protein encoding
            transcripts, suggesting it has a regulatory role in the expression
            of this gene. [provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (5) lacks several exons from the
            5' end, and contains an alternate 5' terminal exon compared to
            variant 2. This results in translation initiation from a downstream
            AUG, and a shorter isoform (5) compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138520.760456.1, AW953378.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..109
                     /product="E3 ubiquitin ligase TRAF3IP2 isoform 5"
                     /EC_number="2.3.2.27"
                     /note="connection to IKK and SAPK/JNK; NFkB-activating
                     protein ACT1; adapter protein CIKS; nuclear factor
                     NF-kappa-B activator 1; E3 ubiquitin-protein ligase CIKS;
                     E3 ubiquitin ligase TRAF3IP2"
                     /calculated_mol_wt=12672
     Region          <1..87
                     /region_name="SEFIR"
                     /note="SEFIR domain; cl23749"
                     /db_xref="CDD:474043"
     CDS             1..109
                     /gene="TRAF3IP2"
                     /gene_synonym="ACT1; C6orf2; C6orf4; C6orf5; C6orf6;
                     CANDF8; CIKS; PSORS13"
                     /coded_by="NM_001164283.3:74..403"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS55049.1"
                     /db_xref="GeneID:10758"
                     /db_xref="HGNC:HGNC:1343"
                     /db_xref="MIM:607043"
ORIGIN      
        1 miivaispky kqdvegaesq ldedehglht kyihrmmqie fikqgsmnfr fipvlfpnak
       61 kehvptwlqn thvyswpknk knillrllre eeyvapprgp lptlqvvpl
//
LOCUS       NP_001397731             198 aa            linear   PRI 27-AUG-2025
DEFINITION  signal-regulatory protein delta isoform 2 precursor [Homo sapiens].
ACCESSION   NP_001397731 XP_047295840
VERSION     NP_001397731.1
DBSOURCE    REFSEQ: accession NM_001410802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 198)
  AUTHORS   van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
            Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
            Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
            Zawatzky,R. and Barclay,A.N.
  TITLE     A nomenclature for signal regulatory protein family members
  JOURNAL   J Immunol 175 (12), 7788-7789 (2005)
   PUBMED   16339511
REFERENCE   2  (residues 1 to 198)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049634.8.
            
            On Aug 16, 2022 this sequence version replaced XP_047295840.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI826712.1, ERR279833.7582.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     Protein         1..198
                     /product="signal-regulatory protein delta isoform 2
                     precursor"
                     /note="protein tyrosine phosphatase, non-receptor type
                     substrate 1-like 2; SIRP-delta"
                     /calculated_mol_wt=18773
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3004
     Region          32..139
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          47..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          61..65
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          100..104
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          114..119
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          132..135
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            175
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9H106.2)"
     CDS             1..198
                     /gene="SIRPD"
                     /gene_synonym="dJ576H24.4; PTPNS1L2"
                     /coded_by="NM_001410802.1:53..649"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS93001.1"
                     /db_xref="GeneID:128646"
                     /db_xref="HGNC:HGNC:16248"
                     /db_xref="MIM:621320"
ORIGIN      
        1 mpipasplhp plpslllyll lelagvthvf hvqqtemsqt vstgesiils csvpntlpng
       61 pvlwfkgtgp nrkliynfkq gnfprvkeig dttkpgntdf strireisla dagtyycvkf
      121 ikgraikeyq sgrgtqvfvt aeqnprppkn rpagragsra hhdahtclsa lpernstnyf
      181 vqpccclrll gltgllsk
//
LOCUS       NP_000143                952 aa            linear   PRI 27-AUG-2025
DEFINITION  lysosomal alpha-glucosidase preproprotein [Homo sapiens].
ACCESSION   NP_000143
VERSION     NP_000143.2
DBSOURCE    REFSEQ: accession NM_000152.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Ruiz-Saavedra,S., Salazar,N., Suarez,A., Diaz,Y., Gonzalez Del
            Rey,C., Gonzalez,S. and de Los Reyes-Gavilan,C.G.
  TITLE     Human fecal alpha-glucosidase activity and its relationship with
            gut microbiota profiles and early stages of intestinal mucosa
            damage
  JOURNAL   Anaerobe 87, 102853 (2024)
   PUBMED   38614290
  REMARK    GeneRIF: Human fecal alpha-glucosidase activity and its
            relationship with gut microbiota profiles and early stages of
            intestinal mucosa damage.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wirth,T., Clement,G., Delvallee,C., Bonnet,C., Bogdan,T., Iosif,A.,
            Schalk,A., Chanson,J.B., Pellerin,D., Brais,B., Roth,V.,
            Wandzel,M., Fleury,M.C., Piton,A., Calmels,N., Namer,I.J.,
            Kremer,S., Tranchant,C., Renaud,M. and Anheim,M.
  TITLE     Natural History and Phenotypic Spectrum of GAA-FGF14 Sporadic
            Late-Onset Cerebellar Ataxia (SCA27B)
  JOURNAL   Mov Disord 38 (10), 1950-1956 (2023)
   PUBMED   37470282
  REMARK    GeneRIF: Natural History and Phenotypic Spectrum of GAA-FGF14
            Sporadic Late-Onset Cerebellar Ataxia (SCA27B).
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Chan,M.Y., Jalil,J.A., Yakob,Y., Wahab,S.A.A., Ali,E.Z.,
            Khalid,M.K.N.M., Leong,H.Y., Chew,H.B., Sivabalakrishnan,J.B. and
            Ngu,L.H.
  TITLE     Genotype, phenotype and treatment outcomes of 17 Malaysian patients
            with infantile-onset Pompe disease and the identification of 3
            novel GAA variants
  JOURNAL   Orphanet J Rare Dis 18 (1), 231 (2023)
   PUBMED   37542277
  REMARK    GeneRIF: Genotype, phenotype and treatment outcomes of 17 Malaysian
            patients with infantile-onset Pompe disease and the identification
            of 3 novel GAA variants.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Lim,J.A., Li,L. and Raben,N.
  TITLE     Pompe disease: from pathophysiology to therapy and back again
  JOURNAL   Front Aging Neurosci 6, 177 (2014)
   PUBMED   25183957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Moreland,R.J., Jin,X., Zhang,X.K., Decker,R.W., Albee,K.L.,
            Lee,K.L., Cauthron,R.D., Brewer,K., Edmunds,T. and Canfield,W.M.
  TITLE     Lysosomal acid alpha-glucosidase consists of four different
            peptides processed from a single chain precursor
  JOURNAL   J Biol Chem 280 (8), 6780-6791 (2005)
   PUBMED   15520017
  REMARK    GeneRIF: data show that the mature forms of GAA characterized by
            polypeptides of 76 or 70 kDa are in fact larger molecular mass
            multicomponent enzyme complexes; peptides released during
            proteolytic processing remained tightly associated with the major
            species
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sperry,E., Leslie,N., Berry,L. and Pena,L.
  TITLE     Pompe Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301438
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Martiniuk,F., Mehler,M., Bodkin,M., Tzall,S., Hirschhorn,K.,
            Zhong,N. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in an adult-onset patient
            with glycogenosis type II expressing only one allele
  JOURNAL   DNA Cell Biol 10 (9), 681-687 (1991)
   PUBMED   1684505
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Zhong,N., Martiniuk,F., Tzall,S. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in one allele of a patient
            with Pompe disease, and use of endonuclease digestion of
            PCR-amplified RNA to demonstrate lack of mRNA expression from the
            second allele
  JOURNAL   Am J Hum Genet 49 (3), 635-645 (1991)
   PUBMED   1652892
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Hermans,M.M., Kroos,M.A., van Beeumen,J., Oostra,B.A. and
            Reuser,A.J.
  TITLE     Human lysosomal alpha-glucosidase. Characterization of the
            catalytic site
  JOURNAL   J Biol Chem 266 (21), 13507-13512 (1991)
   PUBMED   1856189
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Hoefsloot,L.H., Hoogeveen-Westerveld,M., Kroos,M.A., van
            Beeumen,J., Reuser,A.J. and Oostra,B.A.
  TITLE     Primary structure and processing of lysosomal alpha-glucosidase;
            homology with the intestinal sucrase-isomaltase complex
  JOURNAL   EMBO J 7 (6), 1697-1704 (1988)
   PUBMED   3049072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY101855.1, HY047261.1,
            HY015584.1, Y00839.1, BF206270.1, M34424.1, BQ711289.1, BC040431.1
            and BF344248.1.
            
            On Dec 14, 2006 this sequence version replaced NP_000143.1.
            
            Summary: This gene encodes lysosomal alpha-glucosidase, which is
            essential for the degradation of glycogen to glucose in lysosomes.
            The encoded preproprotein is proteolytically processed to generate
            multiple intermediate forms and the mature form of the enzyme.
            Defects in this gene are the cause of glycogen storage disease II,
            also known as Pompe's disease, which is an autosomal recessive
            disorder with a broad clinical spectrum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00839.1, SRR1660809.207766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302262.8/ ENSP00000305692.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..952
                     /product="lysosomal alpha-glucosidase preproprotein"
                     /EC_number="3.2.1.20"
                     /note="lysosomal alpha-glucosidase; acid maltase;
                     aglucosidase alfa; glucosidase alpha, acid"
                     /calculated_mol_wt=102542
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=2800
     Region          47..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
     mat_peptide     70..952
                     /product="Lysosomal alpha-glucosidase. /id=PRO_0000018566"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=98009
     Region          81..132
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(95,125..126)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            order(111,125)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     mat_peptide     123..952
                     /product="76 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018567"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=92314
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Region          159..254
                     /region_name="NtCtMGAM_N"
                     /note="N-terminal barrel of NtMGAM and CtMGAM,
                     maltase-glucoamylase; pfam16863"
                     /db_xref="CDD:465286"
     mat_peptide     204..952
                     /product="70 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018568"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=82826
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Region          246..359
                     /region_name="GH31_N"
                     /note="N-terminal domain of glycosyl hydrolase family 31
                     (GH31); cd14752"
                     /db_xref="CDD:270212"
     Site            282
                     /site_type="active"
                     /db_xref="CDD:270212"
     Region          340..824
                     /region_name="Glyco_hydro_31"
                     /note="Glycosyl hydrolases family 31; pfam01055"
                     /db_xref="CDD:460044"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            470
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            652
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            882
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:8435067; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
     CDS             1..952
                     /gene="GAA"
                     /gene_synonym="IOPD; LOPD; LYAG"
                     /coded_by="NM_000152.5:343..3201"
                     /db_xref="CCDS:CCDS32760.1"
                     /db_xref="GeneID:2548"
                     /db_xref="HGNC:HGNC:4065"
                     /db_xref="MIM:606800"
ORIGIN      
        1 mgvrhppcsh rllavcalvs lataallghi llhdfllvpr elsgsspvle ethpahqqga
       61 srpgprdaqa hpgrpravpt qcdvppnsrf dcapdkaitq eqceargccy ipakqglqga
      121 qmgqpwcffp psypsyklen lsssemgyta tltrttptff pkdiltlrld vmmetenrlh
      181 ftikdpanrr yevpletphv hsrapsplys vefseepfgv ivrrqldgrv llnttvaplf
      241 fadqflqlst slpsqyitgl aehlsplmls tswtritlwn rdlaptpgan lygshpfyla
      301 ledggsahgv fllnsnamdv vlqpspalsw rstggildvy iflgpepksv vqqyldvvgy
      361 pfmppywglg fhlcrwgyss taitrqvven mtrahfpldv qwndldymds rrdftfnkdg
      421 frdfpamvqe lhqggrrymm ivdpaisssg pagsyrpyde glrrgvfitn etgqpligkv
      481 wpgstafpdf tnptalawwe dmvaefhdqv pfdgmwidmn epsnfirgse dgcpnnelen
      541 ppyvpgvvgg tlqaaticas shqflsthyn lhnlygltea iashralvka rgtrpfvisr
      601 stfaghgrya ghwtgdvwss weqlassvpe ilqfnllgvp lvgadvcgfl gntseelcvr
      661 wtqlgafypf mrnhnsllsl pqepysfsep aqqamrkalt lryallphly tlfhqahvag
      721 etvarplfle fpkdsstwtv dhqllwgeal litpvlqagk aevtgyfplg twydlqtvpv
      781 ealgslpppp aaprepaihs egqwvtlpap ldtinvhlra gyiiplqgpg ltttesrqqp
      841 malavaltkg geargelfwd dgeslevler gaytqvifla rnntivnelv rvtsegaglq
      901 lqkvtvlgva tapqqvlsng vpvsnftysp dtkvldicvs llmgeqflvs wc
//
LOCUS       NP_001393671             952 aa            linear   PRI 27-AUG-2025
DEFINITION  lysosomal alpha-glucosidase preproprotein [Homo sapiens].
ACCESSION   NP_001393671 XP_005257251
VERSION     NP_001393671.1
DBSOURCE    REFSEQ: accession NM_001406742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 952)
  AUTHORS   Ruiz-Saavedra,S., Salazar,N., Suarez,A., Diaz,Y., Gonzalez Del
            Rey,C., Gonzalez,S. and de Los Reyes-Gavilan,C.G.
  TITLE     Human fecal alpha-glucosidase activity and its relationship with
            gut microbiota profiles and early stages of intestinal mucosa
            damage
  JOURNAL   Anaerobe 87, 102853 (2024)
   PUBMED   38614290
  REMARK    GeneRIF: Human fecal alpha-glucosidase activity and its
            relationship with gut microbiota profiles and early stages of
            intestinal mucosa damage.
REFERENCE   2  (residues 1 to 952)
  AUTHORS   Wirth,T., Clement,G., Delvallee,C., Bonnet,C., Bogdan,T., Iosif,A.,
            Schalk,A., Chanson,J.B., Pellerin,D., Brais,B., Roth,V.,
            Wandzel,M., Fleury,M.C., Piton,A., Calmels,N., Namer,I.J.,
            Kremer,S., Tranchant,C., Renaud,M. and Anheim,M.
  TITLE     Natural History and Phenotypic Spectrum of GAA-FGF14 Sporadic
            Late-Onset Cerebellar Ataxia (SCA27B)
  JOURNAL   Mov Disord 38 (10), 1950-1956 (2023)
   PUBMED   37470282
  REMARK    GeneRIF: Natural History and Phenotypic Spectrum of GAA-FGF14
            Sporadic Late-Onset Cerebellar Ataxia (SCA27B).
REFERENCE   3  (residues 1 to 952)
  AUTHORS   Chan,M.Y., Jalil,J.A., Yakob,Y., Wahab,S.A.A., Ali,E.Z.,
            Khalid,M.K.N.M., Leong,H.Y., Chew,H.B., Sivabalakrishnan,J.B. and
            Ngu,L.H.
  TITLE     Genotype, phenotype and treatment outcomes of 17 Malaysian patients
            with infantile-onset Pompe disease and the identification of 3
            novel GAA variants
  JOURNAL   Orphanet J Rare Dis 18 (1), 231 (2023)
   PUBMED   37542277
  REMARK    GeneRIF: Genotype, phenotype and treatment outcomes of 17 Malaysian
            patients with infantile-onset Pompe disease and the identification
            of 3 novel GAA variants.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 952)
  AUTHORS   Lim,J.A., Li,L. and Raben,N.
  TITLE     Pompe disease: from pathophysiology to therapy and back again
  JOURNAL   Front Aging Neurosci 6, 177 (2014)
   PUBMED   25183957
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 952)
  AUTHORS   Moreland,R.J., Jin,X., Zhang,X.K., Decker,R.W., Albee,K.L.,
            Lee,K.L., Cauthron,R.D., Brewer,K., Edmunds,T. and Canfield,W.M.
  TITLE     Lysosomal acid alpha-glucosidase consists of four different
            peptides processed from a single chain precursor
  JOURNAL   J Biol Chem 280 (8), 6780-6791 (2005)
   PUBMED   15520017
  REMARK    GeneRIF: data show that the mature forms of GAA characterized by
            polypeptides of 76 or 70 kDa are in fact larger molecular mass
            multicomponent enzyme complexes; peptides released during
            proteolytic processing remained tightly associated with the major
            species
REFERENCE   6  (residues 1 to 952)
  AUTHORS   Sperry,E., Leslie,N., Berry,L. and Pena,L.
  TITLE     Pompe Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301438
REFERENCE   7  (residues 1 to 952)
  AUTHORS   Martiniuk,F., Mehler,M., Bodkin,M., Tzall,S., Hirschhorn,K.,
            Zhong,N. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in an adult-onset patient
            with glycogenosis type II expressing only one allele
  JOURNAL   DNA Cell Biol 10 (9), 681-687 (1991)
   PUBMED   1684505
REFERENCE   8  (residues 1 to 952)
  AUTHORS   Zhong,N., Martiniuk,F., Tzall,S. and Hirschhorn,R.
  TITLE     Identification of a missense mutation in one allele of a patient
            with Pompe disease, and use of endonuclease digestion of
            PCR-amplified RNA to demonstrate lack of mRNA expression from the
            second allele
  JOURNAL   Am J Hum Genet 49 (3), 635-645 (1991)
   PUBMED   1652892
REFERENCE   9  (residues 1 to 952)
  AUTHORS   Hermans,M.M., Kroos,M.A., van Beeumen,J., Oostra,B.A. and
            Reuser,A.J.
  TITLE     Human lysosomal alpha-glucosidase. Characterization of the
            catalytic site
  JOURNAL   J Biol Chem 266 (21), 13507-13512 (1991)
   PUBMED   1856189
REFERENCE   10 (residues 1 to 952)
  AUTHORS   Hoefsloot,L.H., Hoogeveen-Westerveld,M., Kroos,M.A., van
            Beeumen,J., Reuser,A.J. and Oostra,B.A.
  TITLE     Primary structure and processing of lysosomal alpha-glucosidase;
            homology with the intestinal sucrase-isomaltase complex
  JOURNAL   EMBO J 7 (6), 1697-1704 (1988)
   PUBMED   3049072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087741.18.
            
            On May 20, 2022 this sequence version replaced XP_005257251.1.
            
            Summary: This gene encodes lysosomal alpha-glucosidase, which is
            essential for the degradation of glycogen to glucose in lysosomes.
            The encoded preproprotein is proteolytically processed to generate
            multiple intermediate forms and the mature form of the enzyme.
            Defects in this gene are the cause of glycogen storage disease II,
            also known as Pompe's disease, which is an autosomal recessive
            disorder with a broad clinical spectrum. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.12521.1,
                                           SRR14038197.899956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..952
                     /product="lysosomal alpha-glucosidase preproprotein"
                     /EC_number="3.2.1.20"
                     /note="lysosomal alpha-glucosidase; acid maltase;
                     aglucosidase alfa; glucosidase alpha, acid"
                     /calculated_mol_wt=102542
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=2800
     Region          47..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
     mat_peptide     70..952
                     /product="Lysosomal alpha-glucosidase. /id=PRO_0000018566"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=98009
     Region          81..132
                     /region_name="PD"
                     /note="P or trefoil or TFF domain; smart00018"
                     /db_xref="CDD:197472"
     Site            order(95,125..126)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:238059"
     Site            order(111,125)
                     /site_type="active"
                     /note="putative binding specificity loop [active]"
                     /db_xref="CDD:238059"
     mat_peptide     123..952
                     /product="76 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018567"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=92314
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Region          159..254
                     /region_name="NtCtMGAM_N"
                     /note="N-terminal barrel of NtMGAM and CtMGAM,
                     maltase-glucoamylase; pfam16863"
                     /db_xref="CDD:465286"
     mat_peptide     204..952
                     /product="70 kDa lysosomal alpha-glucosidase.
                     /id=PRO_0000018568"
                     /note="propagated from UniProtKB/Swiss-Prot (P10253.4)"
                     /calculated_mol_wt=82826
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Region          246..359
                     /region_name="GH31_N"
                     /note="N-terminal domain of glycosyl hydrolase family 31
                     (GH31); cd14752"
                     /db_xref="CDD:270212"
     Site            282
                     /site_type="active"
                     /db_xref="CDD:270212"
     Region          340..824
                     /region_name="Glyco_hydro_31"
                     /note="Glycosyl hydrolases family 31; pfam01055"
                     /db_xref="CDD:460044"
     Site            390
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            470
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            652
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:29061980,
                     ECO:0000269|PubMed:8435067, ECO:0000269|Ref.19,
                     ECO:0007744|PDB:5KZW, ECO:0007744|PDB:5NN3; propagated
                     from UniProtKB/Swiss-Prot (P10253.4)"
     Site            882
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:29061980, ECO:0000269|PubMed:8435067,
                     ECO:0000269|Ref.19, ECO:0007744|PDB:5KZW,
                     ECO:0007744|PDB:5NN3; propagated from UniProtKB/Swiss-Prot
                     (P10253.4)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218,
                     ECO:0000269|PubMed:8435067; propagated from
                     UniProtKB/Swiss-Prot (P10253.4)"
     CDS             1..952
                     /gene="GAA"
                     /gene_synonym="IOPD; LOPD; LYAG"
                     /coded_by="NM_001406742.1:193..3051"
                     /db_xref="CCDS:CCDS32760.1"
                     /db_xref="GeneID:2548"
                     /db_xref="HGNC:HGNC:4065"
                     /db_xref="MIM:606800"
ORIGIN      
        1 mgvrhppcsh rllavcalvs lataallghi llhdfllvpr elsgsspvle ethpahqqga
       61 srpgprdaqa hpgrpravpt qcdvppnsrf dcapdkaitq eqceargccy ipakqglqga
      121 qmgqpwcffp psypsyklen lsssemgyta tltrttptff pkdiltlrld vmmetenrlh
      181 ftikdpanrr yevpletphv hsrapsplys vefseepfgv ivrrqldgrv llnttvaplf
      241 fadqflqlst slpsqyitgl aehlsplmls tswtritlwn rdlaptpgan lygshpfyla
      301 ledggsahgv fllnsnamdv vlqpspalsw rstggildvy iflgpepksv vqqyldvvgy
      361 pfmppywglg fhlcrwgyss taitrqvven mtrahfpldv qwndldymds rrdftfnkdg
      421 frdfpamvqe lhqggrrymm ivdpaisssg pagsyrpyde glrrgvfitn etgqpligkv
      481 wpgstafpdf tnptalawwe dmvaefhdqv pfdgmwidmn epsnfirgse dgcpnnelen
      541 ppyvpgvvgg tlqaaticas shqflsthyn lhnlygltea iashralvka rgtrpfvisr
      601 stfaghgrya ghwtgdvwss weqlassvpe ilqfnllgvp lvgadvcgfl gntseelcvr
      661 wtqlgafypf mrnhnsllsl pqepysfsep aqqamrkalt lryallphly tlfhqahvag
      721 etvarplfle fpkdsstwtv dhqllwgeal litpvlqagk aevtgyfplg twydlqtvpv
      781 ealgslpppp aaprepaihs egqwvtlpap ldtinvhlra gyiiplqgpg ltttesrqqp
      841 malavaltkg geargelfwd dgeslevler gaytqvifla rnntivnelv rvtsegaglq
      901 lqkvtvlgva tapqqvlsng vpvsnftysp dtkvldicvs llmgeqflvs wc
//
LOCUS       NP_001343937             347 aa            linear   ROD 27-AUG-2025
DEFINITION  P2Y purinoceptor 12 [Mus musculus].
ACCESSION   NP_001343937 XP_006502146
VERSION     NP_001343937.1
DBSOURCE    REFSEQ: accession NM_001357008.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 347)
  AUTHORS   Morimoto,K., Sano,H., Takahashi,M., Takahashi,R. and Nakajima,K.
  TITLE     Comprehensive analysis of immunoglobulin expression in the mouse
            brain from embryonic to adult stages
  JOURNAL   J Neuroinflammation 22 (1), 153 (2025)
   PUBMED   40490799
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 347)
  AUTHORS   Shirahama,S., Okunuki,Y., Lee,M.Y., Karg,M.M., Refaian,N.,
            Krasniqi,D., Connor,K.M., Gregory-Ksander,M.S. and Ksander,B.R.
  TITLE     Preventing the antigen-presenting function of retinal microglia
            blocks autoimmune neuroinflammation by dendritic cell-primed CD4+ T
            cells
  JOURNAL   J Autoimmun 153, 103417 (2025)
   PUBMED   40239533
REFERENCE   3  (residues 1 to 347)
  AUTHORS   McKinsey,G.L., Santander,N., Zhang,X., Kleemann,K.L., Tran,L.,
            Katewa,A., Conant,K., Barraza,M., Waddell,K., Lizama,C.O., La
            Russa,M., Koo,J.H., Lee,H., Mukherjee,D., Paidassi,H., Anton,E.S.,
            Atabai,K., Sheppard,D., Butovsky,O. and Arnold,T.D.
  TITLE     Radial glia integrin avb8 regulates cell autonomous microglial
            TGFbeta1 signaling that is necessary for microglial identity
  JOURNAL   Nat Commun 16 (1), 2840 (2025)
   PUBMED   40121230
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 347)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   5  (residues 1 to 347)
  AUTHORS   Fu,Z., Ganesana,M., Hwang,P., Tan,X., Kinkaid,M.M., Sun,Y.Y.,
            Bian,E., Weybright,A., Chen,H.R., Sol-Church,K., Eyo,U.B.,
            Pridans,C., Quintana,F.J., Robson,S.C., Kumar,P., Venton,B.J.,
            Schaefer,A. and Kuan,C.Y.
  TITLE     Microglia modulate the cerebrovascular reactivity through
            ectonucleotidase CD39
  JOURNAL   Nat Commun 16 (1), 956 (2025)
   PUBMED   39843911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 347)
  AUTHORS   Pausch,M.H., Lai,M., Tseng,E., Paulsen,J., Bates,B. and Kwak,S.
  TITLE     Functional expression of human and mouse P2Y12 receptors in
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 324 (1), 171-177 (2004)
   PUBMED   15464998
  REMARK    GeneRIF: Results describe the cloning of DNA sequences encoding the
            murine ortholog of the human P2Y12 receptor, and its expression in
            the mouse brain.
REFERENCE   7  (residues 1 to 347)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (residues 1 to 347)
  AUTHORS   Schulz,A. and Schoneberg,T.
  TITLE     The structural evolution of a P2Y-like G-protein-coupled receptor
  JOURNAL   J Biol Chem 278 (37), 35531-35541 (2003)
   PUBMED   12835326
REFERENCE   9  (residues 1 to 347)
  AUTHORS   Andre,P., Delaney,S.M., LaRocca,T., Vincent,D., DeGuzman,F.,
            Jurek,M., Koller,B., Phillips,D.R. and Conley,P.B.
  TITLE     P2Y12 regulates platelet adhesion/activation, thrombus growth, and
            thrombus stability in injured arteries
  JOURNAL   J Clin Invest 112 (3), 398-406 (2003)
   PUBMED   12897207
  REMARK    GeneRIF: role of P2Y12 in platelet thrombosis and how its complete
            absence affects the thrombotic process
REFERENCE   10 (residues 1 to 347)
  AUTHORS   Foster,C.J., Prosser,D.M., Agans,J.M., Zhai,Y., Smith,M.D.,
            Lachowicz,J.E., Zhang,F.L., Gustafson,E., Monsma,F.J. Jr.,
            Wiekowski,M.T., Abbondanzo,S.J., Cook,D.N., Bayne,M.L., Lira,S.A.
            and Chintala,M.S.
  TITLE     Molecular identification and characterization of the platelet ADP
            receptor targeted by thienopyridine antithrombotic drugs
  JOURNAL   J Clin Invest 107 (12), 1591-1598 (2001)
   PUBMED   11413167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122038.3.
            
            On Oct 14, 2017 this sequence version replaced XP_006502146.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.192097.1,
                                           ERR3363658.5465037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.01 cM"
     Protein         1..347
                     /product="P2Y purinoceptor 12"
                     /calculated_mol_wt=39343
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Site            12
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          32..315
                     /region_name="7tmA_P2Y12"
                     /note="P2Y purinoceptor 12, member of the class A family
                     of seven-transmembrane G protein-coupled receptors;
                     cd15150"
                     /db_xref="CDD:341326"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341326"
     Site            34..56
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPX4; propagated from
                     UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPX4; propagated from
                     UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          65..90
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341326"
     Site            68..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Site            order(99,103,107..108,111..112,115,158,161..162,165,169,
                     180..181,185,193,196..197,200,262,265,269,286)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:341326"
     Region          103..133
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341326"
     Site            104..124
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          145..167
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341326"
     Site            149..168
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341326"
     Site            192..213
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Site            240..265
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          241..269
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341326"
     Region          282..306
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341326"
     Site            285..304
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     Region          321..347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CPV9.1)"
     CDS             1..347
                     /gene="P2ry12"
                     /gene_synonym="2900079B22Rik; 4921504D23Rik; P2Y12"
                     /coded_by="NM_001357008.1:576..1619"
                     /db_xref="CCDS:CCDS17373.1"
                     /db_xref="GeneID:70839"
                     /db_xref="MGI:MGI:1918089"
ORIGIN      
        1 mdvpgvntts anttfspgts tlcvrdykit qvlfpllytv lffaglitns lamriffqir
       61 sksnfiiflk ntvisdllmi ltfpfkilsd aklgagplrt lvcqvtsvtf yftmyisisf
      121 lglitidryl kttrpfktss psnllgakil svviwafmfl islpnmiltn rrpkdkdvtk
      181 csflksefgl vwheivnyic qvifwinfli vivcyslitk elyrsyvrtr gsakvpkkkv
      241 nvkvfiiiav fficfvpfhf aripytlsqt ravfdcsaen tlfyvkestl wltslnacld
      301 pfiyfflcks frnsltsmlr csnststsgt nkkkgqegge pseetpm
//
LOCUS       NP_080853                427 aa            linear   ROD 27-AUG-2025
DEFINITION  ADP-ribosylation factor-like protein 13B [Mus musculus].
ACCESSION   NP_080853
VERSION     NP_080853.3
DBSOURCE    REFSEQ: accession NM_026577.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 427)
  AUTHORS   Nita,A., Abraham,S.P., Elrefaay,E.R., Fafilek,B., Cizkova,E.,
            Ursachi,V.C., Gudernova,I., Koudelka,A., Dudeja,P., Gregor,T.,
            Feketova,Z., Rico,G., Svozilova,K., Celiker,C., Czyrek,A.A.,
            Barta,T., Trantirek,L., Wiedlocha,A., Krejci,P. and Bosakova,M.
  TITLE     FGFR2 residence in primary cilia is necessary for epithelial cell
            signaling
  JOURNAL   J Cell Biol 224 (7) (2025)
   PUBMED   40257378
REFERENCE   2  (residues 1 to 427)
  AUTHORS   Tran,L.N., Shinde,A., Schuster,K.H., Sabaawy,A., Dale,E.,
            Welch,M.J., Isner,T.J., Nunez,S.A., Garcia-Moreno,F.,
            Sagerstrom,C.G., Appel,B.H. and Franco,S.J.
  TITLE     Epigenetic priming of neural progenitors by Notch enhances Sonic
            hedgehog signaling and establishes gliogenic competence
  JOURNAL   Genes Dev 39 (13-14), 886-906 (2025)
   PUBMED   40404401
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 427)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   4  (residues 1 to 427)
  AUTHORS   Yang,J., Mirhosseiniardakani,S., Qiu,L., Bicja,K., Del Greco,A.,
            Lin,K.J., Lyon,M. and Chen,X.
  TITLE     Cilia directionality reveals a slow reverse movement of principal
            neurons for positioning and lamina refinement in the cerebral
            cortex
  JOURNAL   Development 152 (5) (2025)
   PUBMED   40066717
REFERENCE   5  (residues 1 to 427)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 427)
  AUTHORS   Zeng,H., Hoover,A.N. and Liu,A.
  TITLE     PCP effector gene Inturned is an important regulator of cilia
            formation and embryonic development in mammals
  JOURNAL   Dev Biol 339 (2), 418-428 (2010)
   PUBMED   20067783
REFERENCE   7  (residues 1 to 427)
  AUTHORS   Weatherbee,S.D., Niswander,L.A. and Anderson,K.V.
  TITLE     A mouse model for Meckel syndrome reveals Mks1 is required for
            ciliogenesis and Hedgehog signaling
  JOURNAL   Hum Mol Genet 18 (23), 4565-4575 (2009)
   PUBMED   19776033
REFERENCE   8  (residues 1 to 427)
  AUTHORS   Heydeck,W., Zeng,H. and Liu,A.
  TITLE     Planar cell polarity effector gene Fuzzy regulates cilia formation
            and Hedgehog signal transduction in mouse
  JOURNAL   Dev Dyn 238 (12), 3035-3042 (2009)
   PUBMED   19877275
REFERENCE   9  (residues 1 to 427)
  AUTHORS   Zhang,H., Ables,E.T., Pope,C.F., Washington,M.K., Hipkens,S.,
            Means,A.L., Path,G., Seufert,J., Costa,R.H., Leiter,A.B.,
            Magnuson,M.A. and Gannon,M.
  TITLE     Multiple, temporal-specific roles for HNF6 in pancreatic endocrine
            and ductal differentiation
  JOURNAL   Mech Dev 126 (11-12), 958-973 (2009)
   PUBMED   19766716
REFERENCE   10 (residues 1 to 427)
  AUTHORS   Caspary,T., Larkins,C.E. and Anderson,K.V.
  TITLE     The graded response to Sonic Hedgehog depends on cilia architecture
  JOURNAL   Dev Cell 12 (5), 767-778 (2007)
   PUBMED   17488627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK021270.1, AK016794.1, CF741686.1 and AC154309.1.
            
            On Aug 8, 2009 this sequence version replaced NP_080853.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1274736.1,
                                           SRR7974084.12527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 36.43 cM"
     Protein         1..427
                     /product="ADP-ribosylation factor-like protein 13B"
                     /note="ADP-ribosylation factor-like 2-like 1; ARL2-like
                     protein 1; protein hennin"
                     /calculated_mol_wt=48013
     Region          23..189
                     /region_name="Arl2l1_Arl13_like"
                     /note="Arl2-like protein 1 (Arl2l1) and Arl13; cd04161"
                     /db_xref="CDD:133361"
     Site            28..35
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133361"
     Site            order(30..36,51..52,74,130..131,133,166..168)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:133361"
     Site            order(30..31,35,39,51..58,80,85)
                     /site_type="other"
                     /note="putative GAP interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133361"
     Site            order(40..43,45..55)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:133361"
     Site            order(52..56,61,71,75,81,83..85)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133361"
     Site            52
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133361"
     Site            order(53..60,70,81,84..85)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133361"
     Site            order(56..62,65..70)
                     /site_type="active"
                     /note="interswitch region [active]"
                     /db_xref="CDD:133361"
     Site            71..88
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:133361"
     Site            71..74
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:133361"
     Site            130..133
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133361"
     Site            166..168
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133361"
     Region          207..250
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q640N2.2)"
     Region          269..427
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q640N2.2)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q640N2.2)"
     CDS             1..427
                     /gene="Arl13b"
                     /gene_synonym="A530097K21Rik; A930014M17Rik; Arl2l1;
                     C530009C10Rik; hnn"
                     /coded_by="NM_026577.4:298..1581"
                     /db_xref="CCDS:CCDS28261.1"
                     /db_xref="GeneID:68146"
                     /db_xref="MGI:MGI:1915396"
ORIGIN      
        1 mfslmanccn lfkrwrepvr kvtlvmvgld nagktatakg iqgehpedva ptvgfskidl
       61 rqgkfqvtif dlgggkrirg iwknyyaesy gvifvvdssd eermeetket msevlrhpri
      121 sgkpilvlan kqdkegalge advieclsle klvnehkclc qiepcsavlg ygkkidksik
      181 kglywllhii akdfdalser iqkdtteqra leeqekrera ervrklreer ereqteldgt
      241 sglaeidsgp vlanpfqpia aviienekkq ekekkkqtve kdsdvglleh kvepeqaapq
      301 seadcclqnp dervvdsyre alsqqldsed eqdqrgsesg enskkktkkl rmkrshrvep
      361 vntdestpks ptppqppppv gwgtpkvtrl pkleplgetr hndfygkplp plavrqrpng
      421 daqdtis
//
LOCUS       NP_001191340             303 aa            linear   ROD 27-AUG-2025
DEFINITION  ATP-sensitive inward rectifier potassium channel 11 isoform 2 [Mus
            musculus].
ACCESSION   NP_001191340
VERSION     NP_001191340.1
DBSOURCE    REFSEQ: accession NM_001204411.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 303)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 303)
  AUTHORS   Stokum,J.A., Shim,B., Negoita,S., Tsymbalyuk,N., Tsymbalyuk,O.,
            Ivanova,S., Keledjian,K., Bryan,J., Blaustein,M.P., Jha,R.M.,
            Kahle,K.T., Gerzanich,V. and Simard,J.M.
  TITLE     Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet
            induces water influx through AQP4 and brain swelling after ischemic
            stroke
  JOURNAL   Sci Signal 16 (788), eadd6364 (2023)
   PUBMED   37279286
REFERENCE   4  (residues 1 to 303)
  AUTHORS   Grizzanti,J., Moritz,W.R., Pait,M.C., Stanley,M., Kaye,S.D.,
            Carroll,C.M., Constantino,N.J., Deitelzweig,L.J., Snipes,J.A.,
            Kellar,D., Caesar,E.E., Pettit-Mee,R.J., Day,S.M., Sens,J.P.,
            Nicol,N.I., Dhillon,J., Remedi,M.S., Kiraly,D.D., Karch,C.M.,
            Nichols,C.G., Holtzman,D.M. and Macauley,S.L.
  TITLE     KATP channels are necessary for glucose-dependent increases in
            amyloid-beta and Alzheimer's disease-related pathology
  JOURNAL   JCI Insight 8 (10), e162454 (2023)
   PUBMED   37129980
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 303)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 303)
  AUTHORS   Suzuki,M., Fujikura,K., Inagaki,N., Seino,S. and Takata,K.
  TITLE     Localization of the ATP-sensitive K+ channel subunit Kir6.2 in
            mouse pancreas
  JOURNAL   Diabetes 46 (9), 1440-1444 (1997)
   PUBMED   9287044
REFERENCE   7  (residues 1 to 303)
  AUTHORS   Yamada,M., Isomoto,S., Matsumoto,S., Kondo,C., Shindo,T., Horio,Y.
            and Kurachi,Y.
  TITLE     Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive
            but ATP-insensitive K+ channel
  JOURNAL   J Physiol 499 (Pt 3) (Pt 3), 715-720 (1997)
   PUBMED   9130167
REFERENCE   8  (residues 1 to 303)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P., Wang,C.Z., Aguilar-Bryan,L.,
            Bryan,J. and Seino,S.
  TITLE     A family of sulfonylurea receptors determines the pharmacological
            properties of ATP-sensitive K+ channels
  JOURNAL   Neuron 16 (5), 1011-1017 (1996)
   PUBMED   8630239
REFERENCE   9  (residues 1 to 303)
  AUTHORS   Sakura,H., Ammala,C., Smith,P.A., Gribble,F.M. and Ashcroft,F.M.
  TITLE     Cloning and functional expression of the cDNA encoding a novel
            ATP-sensitive potassium channel subunit expressed in pancreatic
            beta-cells, brain, heart and skeletal muscle
  JOURNAL   FEBS Lett 377 (3), 338-344 (1995)
   PUBMED   8549751
REFERENCE   10 (residues 1 to 303)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115036.10.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ895556.1, SRR17784648.104808.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     Protein         1..303
                     /product="ATP-sensitive inward rectifier potassium channel
                     11 isoform 2"
                     /note="ATP-sensitive inward rectifier potassium channel
                     11; inward rectifier K(+) channel Kir6.2"
                     /calculated_mol_wt=33122
     Region          <1..87
                     /region_name="IRK"
                     /note="Inward rectifier potassium channel transmembrane
                     domain; pfam01007"
                     /db_xref="CDD:460023"
     Region          94..267
                     /region_name="IRK_C"
                     /note="Inward rectifier potassium channel C-terminal
                     domain; pfam17655"
                     /db_xref="CDD:465439"
     CDS             1..303
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /coded_by="NM_001204411.2:181..1092"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:16514"
                     /db_xref="MGI:MGI:107501"
ORIGIN      
        1 mvwwliafah gdlapgegtn vpcvtsihsf ssaflfsiev qvtigfggrm vteecplail
       61 ilivqnivgl minaimlgci fmktaqahrr aetlifskha vitlrhgrlc fmlrvgdlrk
      121 smiisatihm qvvrkttspe gevvplhqvd ipmengvggn giflvaplii yhvidsnspl
      181 ydlapsdlhh hqdleiivil egvvettgit tqartsylad eilwgqrfvp ivaeedgrys
      241 vdyskfgnti kvptplctar qldedrslld altlassrgp lrkrsvavak akpkfsispd
      301 sls
//
LOCUS       NP_001389659            2783 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 2 [Mus musculus].
ACCESSION   NP_001389659 XP_030106147
VERSION     NP_001389659.1
DBSOURCE    REFSEQ: accession NM_001402730.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2783)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2783)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2783)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2783)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2783)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2783)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2783)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2783)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2783)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2783)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Mar 21, 2022 this sequence version replaced XP_030106147.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.690691.1,
                                           SRR7345562.5002438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2783
                     /product="adenomatous polyposis coli protein isoform 2"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=304060
     Region          66..146
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          279..331
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          332..405
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          398..449
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          404..447
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(438,442,446,481,485,489,525,529,533)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          451..492
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          455..492
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          499..534
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          542..583
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          588..628
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          592..626
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          630..670
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          634..670
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          671..958
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          975..1074
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1196..>1213
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1222..1308
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1576..1599
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1601..1654
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1655..1676
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1685..1778
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1812..1886
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          1973..1992
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2164..2509
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2611..2783
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2783
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402730.1:402..8753"
                     /note="isoform 2 is encoded by transcript variant 7"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 mtsgqidlle rlkefnldsn fpgvklrskm slrsygsreg svssrsgecs pvpmgsfprr
       61 tfvngsrest gyleeleker sllladldke ekekdwyyaq lqnltkrids lpltenfslq
      121 tdmtrrqley earqiraame eqlgtcqdme kraqrriari qqiekdilrv rqllqsqaae
      181 aerssqsrhd aasheagrqh eghgvaesnt aasssgqspa trvdhetasv lsssgthsap
      241 rrltshlgtk vemvysllsm lgthdkddms rtllamsssq dscismrqsg clplliqllh
      301 gndkdsvllg nsrgskeara rasaalhnii hsqpddkrgr reirvlhlle qiraycetcw
      361 ewqeaheqgm dqdknpmpap vehqicpavc vlmklsfdee hrhamnelgg lqaiaellqv
      421 dcemygltnd hysvtlrrya gmaltnltfg dvankatlcs mkgcmralva qlksesedlq
      481 qviasvlrnl swradvnskk tlrevgsvka lmecalevkk estlksvlsa lwnlsahcte
      541 nkadicavdg alaflvgtlt yrsqtntlai iesgggilrn vssliatned hrqilrennc
      601 lqtllqhlks hsltivsnac gtlwnlsarn pkdqealwdm gavsmlknli hskhkmiamg
      661 saaalrnlma nrpakykdan imspgsslps lhvrkqkale aeldaqhlse tfdnidnlsp
      721 kashrskqrh kqnlygdyaf danrhddsrs dnfntgnmtv lspylnttvl psssssrgsl
      781 dssrsekdrs lerergigls ayhpttenag tsskrglqit ttaaqiakvm eevsaihtsq
      841 ddrssastte fhcvaddrsa arrssashth sntynftkse nsnrtcsmpy akveykrssn
      901 dslnsvtssd gygkrgqmkp svesysedde skfcsygqyp adlahkihsa nhmddndgel
      961 dtpinyslky sdeqlnsgrq spsqnerwar pkhviedeik qneqrqarsq ntsypvysen
     1021 tddkhlkfqp hfgqqecvsp yrsrgtsgse tnrmgsshai nqnvnqslcq eddyeddkpt
     1081 nyseryseee qheeeeerpt nysikyneek hhvdqpidys lkyatdisss qkpsfsfskn
     1141 ssaqstkpeh lspssentav ppsnakrqnq lrpssaqrng qtqkgttckv psinqetiqt
     1201 ycvedtpicf srcsslssls saddeigcdq ttqeadsant lqtaevkend vtrsaedpat
     1261 evpavsqnar akpsrlqasg lssestrhnk avefssgaks psksgaqtpk sppehyvqet
     1321 plvfsrctsv ssldsfesrs iassvqsepc sgmvsgiisp sdlpdspgqt mppsrsktpp
     1381 pppqtvqakr evpkskvpaa ekresgpkqt avnaavqrvq vlpdvdtllh fatestpdgf
     1441 scssslsals ldepfiqkdv elrimppvqe ndngnetese qpeesnenqd kevekpdsek
     1501 dllddsdddd ieileeciis amptkssrka kklaqtaskl pppvarkpsq lpvykllpaq
     1561 nrlqaqkhvs ftpgddvprv ycvegtpinf statslsdlt iesppnelat gdgvragiqs
     1621 gefekrdtip tegrstddaq rgkissivtp dlddnkaeeg dilaecinsa mpkgkshkpf
     1681 rvkkimdqvq qasstssgan knqvdtkkkk ptspvkpmpq nteyrtrvrk ntdskvnvnt
     1741 eetfsdnkds kkpslqtnak afneklpnne drvrgsfald sphhytpieg tpycfsrnds
     1801 lssldfdddd vdlsrekael rkgkeskdse akvtcrpepn ssqqaasksq asikhpanra
     1861 qskpvlqkqp tfpqsskdgp drgaatdekl qnfaientpv cfsrnsslss lsdidqennn
     1921 nkesepikea epansqgeps kpqasgyapk sfhvedtpvc fsrnsslssl sidseddllq
     1981 ecissampkk krpsrlkses ekqsprkvgg ilaedltldl kdlqrpdseh afspdsenfd
     2041 wkaiqegans ivsslhqaaa aaaclsrqas sdsdsilslk sgislgspfh ltpdqeekpf
     2101 tsnkgprilk pgekstleak kiesenkgik ggkkvyksli tgkirsnsei ssqmkqplpt
     2161 nmpsisrgrt mihipglrns ssstspvskk gpplktpask spsegpgatt sprgtkpagk
     2221 selspitrqt sqisgsnkgs srsgsrdstp srptqqplsr pmqspgrnsi spgrngispp
     2281 nklsqlprts spstastkss gsgkmsytsp grqlsqqnlt kqaslsknas siprsesask
     2341 glnqmsngng snkkvelsrm sstkssgses drserpalvr qstfikeaps ptlrrklees
     2401 asfeslspss rpdsptrsqa qtpvlspslp dmslsthpsv qaggwrklpp nlsptieynd
     2461 grptkrhdia rshsespsrl pinragtwkr ehskhssslp rvstwrrtgs sssilsasse
     2521 ssekaksede rhvssmpapr qmkenqvptk gtwrkikesd isptgmasqs assgaasgae
     2581 skpliyqmap pvsktedvwv riedcpinnp rsgrsptgnt ppvidsvsek gsssikdskd
     2641 thgkqsvgsg spvqtvglet rlnsfvqvea peqkgteakp gqsnpvsiae taetciaert
     2701 pfsssssskh sspsgtvaar vtpfnynpsp rkssadstsa rpsqiptpvs tntkkrdskt
     2761 dstessgaqs pkrhsgsylv tsv
//
LOCUS       NP_001396723             802 aa            linear   ROD 27-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Mus
            musculus].
ACCESSION   NP_001396723 XP_036018851
VERSION     NP_001396723.1
DBSOURCE    REFSEQ: accession NM_001409794.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 802)
  AUTHORS   Acero-Bedoya,S., Higgs,E.F., Martinez,A.C., Tonea,R. and
            Gajewski,T.F.
  TITLE     Dendritic cell-intrinsic PTPN22 negatively regulates antitumor
            immunity and impacts anti-PD-L1 efficacy
  JOURNAL   J Immunother Cancer 12 (10), e009588 (2024)
   PUBMED   39461876
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 802)
  AUTHORS   Cai,H., Chen,S., Jiang,Z., Chen,L. and Yang,X.
  TITLE     PTPN22 through the regulation of Th17/Treg balance acts as a
            potential target for the treatment of Graves' disease
  JOURNAL   Tissue Cell 90, 102502 (2024)
   PUBMED   39083881
  REMARK    GeneRIF: PTPN22 through the regulation of Th17/Treg balance acts as
            a potential target for the treatment of Graves' disease.
REFERENCE   3  (residues 1 to 802)
  AUTHORS   Lee,J., Yurkovetskiy,L.A., Reiman,D., Frommer,L., Strong,Z.,
            Chang,A., Kahaly,G.J., Khan,A.A. and Chervonsky,A.V.
  TITLE     Androgens contribute to sex bias of autoimmunity in mice by T
            cell-intrinsic regulation of Ptpn22 phosphatase expression
  JOURNAL   Nat Commun 15 (1), 7688 (2024)
   PUBMED   39227386
  REMARK    GeneRIF: Androgens contribute to sex bias of autoimmunity in mice
            by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 802)
  AUTHORS   Orozco,R.C., Marquardt,K., Pratumchai,I., Shaikh,A.F., Mowen,K.,
            Domissy,A., Teijaro,J.R. and Sherman,L.A.
  TITLE     Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22
            enhances anti-viral immunity
  JOURNAL   PLoS Pathog 20 (3), e1012095 (2024)
   PUBMED   38512979
  REMARK    GeneRIF: Autoimmunity-associated allele of tyrosine phosphatase
            gene PTPN22 enhances anti-viral immunity.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 802)
  AUTHORS   Li,S., Luo,Z., Su,S., Wen,L., Xian,G., Zhao,J., Xu,X., Xu,D. and
            Zeng,Q.
  TITLE     Targeted inhibition of PTPN22 is a novel approach to alleviate
            osteogenic responses in aortic valve interstitial cells and aortic
            valve lesions in mice
  JOURNAL   BMC Med 21 (1), 252 (2023)
   PUBMED   37443055
  REMARK    GeneRIF: Targeted inhibition of PTPN22 is a novel approach to
            alleviate osteogenic responses in aortic valve interstitial cells
            and aortic valve lesions in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 802)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (residues 1 to 802)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (residues 1 to 802)
  AUTHORS   Gregorieff,A., Cloutier,J.F. and Veillette,A.
  TITLE     Sequence requirements for association of protein-tyrosine
            phosphatase PEP with the Src homology 3 domain of inhibitory
            tyrosine protein kinase p50(csk)
  JOURNAL   J Biol Chem 273 (21), 13217-13222 (1998)
   PUBMED   9582365
REFERENCE   9  (residues 1 to 802)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   10 (residues 1 to 802)
  AUTHORS   Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L.
  TITLE     Characterization of hematopoietic intracellular protein tyrosine
            phosphatases: description of a phosphatase containing an SH2 domain
            and another enriched in proline-, glutamic acid-, serine-, and
            threonine-rich sequences
  JOURNAL   Mol Cell Biol 12 (5), 2396-2405 (1992)
   PUBMED   1373816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124698.4.
            
            On Jul 22, 2022 this sequence version replaced XP_036018851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.124863.1,
                                           SRR1660821.141970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     Protein         1..802
                     /product="tyrosine-protein phosphatase non-receptor type
                     22 isoform 1"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, non-receptor type 8;
                     PEST domain-enriched tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 22;
                     hematopoietic cell protein-tyrosine phosphatase 70Z-PEP"
                     /calculated_mol_wt=89584
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCD.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2R2; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          57..290
                     /region_name="PTPc-N22"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 22; cd14602"
                     /db_xref="CDD:350450"
     Region          330..358
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          536..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          597..619
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          613..621
                     /region_name="Interaction with CSK.
                     /evidence=ECO:0000269|PubMed:8890164"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            634
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          653..695
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            680
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Site            687
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          713..802
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     CDS             1..802
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /coded_by="NM_001409794.1:599..3007"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
ORIGIN      
        1 mdqreilqql lkeaqkkkln seefaseflk lkrqstkyka dkiypttvaq rpknikknry
       61 kdilpydhsl velslltsde dssyinasfi kgvygpkayi atqgplsttl ldfwrmiwey
      121 rilvivmacm efemgkkkce rywaepgetq lqfgpfsisc eaekkksdyk irtlkakfnn
      181 etriiyqfhy knwpdhdvps sidpilqliw dmrcyqeddc vpicihcsag cgrtgvicav
      241 dytwmllkdg iipknfsvfn liqemrtqrp slvqtqeqye lvysavlelf krhmdvisdn
      301 hlgreiqaqc sipeqsltve adscpldlpk namrdvkttn qhskqgaeae stggsslglr
      361 tstmnaeeel vlhsakssps fnclelncgc nnkavitrng qaraspvvge plqkyqsldf
      421 gsmlfgscps alpintadry hnskgpvkrt kstpfeliqq rktndlavgd gfsclesqlh
      481 ehyslrelqv qrvahvssee lnyslpgacd ascvprhspg alrvhlytsl aedpyfsssp
      541 pnsadskmsf dlpekqdgat spgallpass ttsffysnph dslvmntlts fspplnqeta
      601 veapsrrtdd eippplpert pesfivveea gepsprvtes lplvvtfgas pecsgtsemk
      661 shdsvgftps knvklrspks drhqdgsppp plpertlesf fladedciqa qavqtsstsy
      721 pettenstss kqtlrtpgks ftrskslkif rnmkksvcns sspskpterv qpknsssfln
      781 fgfgnrfskp kgprnppsaw nm
//
LOCUS       NP_001395641             158 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
            [Mus musculus].
ACCESSION   NP_001395641
VERSION     NP_001395641.1
DBSOURCE    REFSEQ: accession NM_001408712.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 158)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 158)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 158)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 158)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 158)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 158)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 158)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 158)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 158)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 158)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1498071.1,
                                           SRR7652917.450065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..158
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 6"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=17918
     Region          49..143
                     /region_name="PWWP"
                     /note="PWWP (Pro-Trp-Trp-Pro) domain; cl02554"
                     /db_xref="CDD:470613"
     Site            order(65,68,99)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438958"
     Site            66..69
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438958"
     CDS             1..158
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408712.1:238..714"
                     /note="isoform 6 is encoded by transcript variant 16"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mppktrtals ddpdsspspl gnmleipgts spstsqelpf cqpkkkstpl kyevgdliwa
       61 kfkrrpwwpc ricsdplint hskmkvanrr pyreyyveaf gdpsekawva gkaivmfegr
      121 hqfeelpvlr krgkqkekgy rhktgflcva lavleltl
//
LOCUS       NP_001273986             190 aa            linear   ROD 27-AUG-2025
DEFINITION  vascular endothelial growth factor A, long form isoform Vegf-A
            precursor [Mus musculus].
ACCESSION   NP_001273986
VERSION     NP_001273986.1
DBSOURCE    REFSEQ: accession NM_001287057.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 190)
  AUTHORS   Man,X., Usui,N., Doi,M. and Shimada,S.
  TITLE     Sex differences in placental structure and gene expression in ICR
            mice during embryonic development
  JOURNAL   Sci Rep 15 (1), 24067 (2025)
   PUBMED   40617958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 190)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   3  (residues 1 to 190)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 190)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (residues 1 to 190)
  AUTHORS   Bastide,A., Karaa,Z., Bornes,S., Hieblot,C., Lacazette,E., Prats,H.
            and Touriol,C.
  TITLE     An upstream open reading frame within an IRES controls expression
            of a specific VEGF-A isoform
  JOURNAL   Nucleic Acids Res 36 (7), 2434-2445 (2008)
   PUBMED   18304943
REFERENCE   6  (residues 1 to 190)
  AUTHORS   Huez,I., Bornes,S., Bresson,D., Creancier,L. and Prats,H.
  TITLE     New vascular endothelial growth factor isoform generated by
            internal ribosome entry site-driven CUG translation initiation
  JOURNAL   Mol Endocrinol 15 (12), 2197-2210 (2001)
   PUBMED   11731620
REFERENCE   7  (residues 1 to 190)
  AUTHORS   Tee,M.K. and Jaffe,R.B.
  TITLE     A precursor form of vascular endothelial growth factor arises by
            initiation from an upstream in-frame CUG codon
  JOURNAL   Biochem J 359 (Pt 1), 219-226 (2001)
   PUBMED   11563986
REFERENCE   8  (residues 1 to 190)
  AUTHORS   Meiron,M., Anunu,R., Scheinman,E.J., Hashmueli,S. and Levi,B.Z.
  TITLE     New isoforms of VEGF are translated from alternative initiation CUG
            codons located in its 5'UTR
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1053-1060 (2001)
   PUBMED   11352659
REFERENCE   9  (residues 1 to 190)
  AUTHORS   Claffey,K.P., Wilkison,W.O. and Spiegelman,B.M.
  TITLE     Vascular endothelial growth factor. Regulation by cell
            differentiation and activated second messenger pathways
  JOURNAL   J Biol Chem 267 (23), 16317-16322 (1992)
   PUBMED   1644816
REFERENCE   10 (residues 1 to 190)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY001490.1, CK626177.1,
            BC061468.1 and AK031905.1.
            
            Summary: This gene is a member of the PDGF/VEGF growth factor
            family. It encodes a heparin-binding protein, which exists as a
            disulfide-linked homodimer. This growth factor induces
            proliferation and migration of vascular endothelial cells, and is
            essential for both physiological and pathological angiogenesis.
            Disruption of this gene in mice resulted in abnormal embryonic
            blood vessel formation. This gene is upregulated in many known
            tumors and its expression is correlated with tumor stage and
            progression. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. There is also
            evidence for alternative translation initiation from upstream
            non-AUG (CUG) codons resulting in additional isoforms. A recent
            study showed that a C-terminally extended isoform is produced by
            use of an alternative in-frame translation termination codon via a
            stop codon readthrough mechanism, and that this isoform is
            antiangiogenic. Expression of some isoforms derived from the AUG
            start codon is regulated by a small upstream open reading frame,
            which is located within an internal ribosome entry site.[provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2) lacks an internal, in-frame
            coding exon compared to variant 1. It can initiate translation from
            a non-AUG (CUG) codon, and also from an in-frame, downstream AUG
            start codon. The isoform (Vegf-A) represented in this RefSeq is
            derived from the AUG start codon. It has a shorter N-terminus and
            lacks an internal protein segment compared to isoform 1. This
            variant also encodes a C-terminally extended isoform (Vegf-Ax),
            which results from the use of an alternative in-frame, downstream
            translation termination codon (UAA). Isoform Vegf-Ax is represented
            in NM_001317041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061468.1, SRR1660821.338789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 18304943
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..190
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.79 cM"
     Protein         1..190
                     /product="vascular endothelial growth factor A, long form
                     isoform Vegf-A precursor"
                     /note="vascular permeability factor; vascular endothelial
                     growth factor A, long form"
                     /calculated_mol_wt=19278
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3180
     mat_peptide     27..190
                     /product="vascular endothelial growth factor A, long form
                     isoform Vegf-A"
                     /calculated_mol_wt=19278
     Region          49..131
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; smart00141"
                     /db_xref="CDD:197537"
     Site            order(49..52,86,88..91,106..109)
                     /site_type="active"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     Site            order(51,82,86,93,127,129)
                     /site_type="other"
                     /note="cysteine knot motif"
                     /db_xref="CDD:238079"
     Site            order(76,85)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238079"
     Region          142..190
                     /region_name="VEGF_C"
                     /note="VEGF heparin-binding domain; pfam14554"
                     /db_xref="CDD:405273"
     CDS             1..190
                     /gene="Vegfa"
                     /gene_synonym="L-VEGF; Vegf; Vpf"
                     /coded_by="NM_001287057.1:1022..1594"
                     /note="isoform Vegf-A precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:22339"
                     /db_xref="MGI:MGI:103178"
ORIGIN      
        1 mnfllswvhw tlalllylhh akwsqaaptt egeqkshevi kfmdvyqrsy crpietlvdi
       61 fqeypdeiey ifkpscvplm rcagccndea lecvptsesn itmqimrikp hqsqhigems
      121 flqhsrcecr pkkdrtkpen hcepcserrk hlfvqdpqtc kcsckntdsr ckarqlelne
      181 rtcrcdkprr
//
LOCUS       NP_001344072             284 aa            linear   ROD 27-AUG-2025
DEFINITION  deoxyribonuclease-1 precursor [Mus musculus].
ACCESSION   NP_001344072 XP_006521837
VERSION     NP_001344072.1
DBSOURCE    REFSEQ: accession NM_001357143.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 284)
  AUTHORS   Englert,H., Rangaswamy,C., Kullik,G.A., Divivier,M., Gobel,J.,
            Hermans-Borgmeyer,I., Borgmeyer,U., Mowen,K.A., Beerens,M.,
            Frye,M., Mailer,R.K., Gelderblom,M., Stavrou,E.X., Preston,R.J.S.,
            Schneider,S.W., Fuchs,T.A. and Renne,T.
  TITLE     Sepsis-induced NET formation requires MYD88 but is independent of
            GSDMD and PAD4
  JOURNAL   FASEB J 39 (1), e70301 (2025)
   PUBMED   39777764
REFERENCE   2  (residues 1 to 284)
  AUTHORS   Stabach,P.R., Sims,D., Gomez-Banuelos,E., Zehentmeier,S.,
            Dammen-Brower,K., Bernhisel,A., Kujawski,S., Lopez,S.G., Petri,M.,
            Goldman,D.W., Lester,E.R., Le,Q., Ishaq,T., Kim,H., Srivastava,S.,
            Kumar,D., Pereira,J.P., Yarema,K.J., Koumpouras,F., Andrade,F. and
            Braddock,D.T.
  TITLE     A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and
            death in genetic and induced lupus models
  JOURNAL   JCI Insight 9 (14), e177003 (2024)
   PUBMED   38888971
  REMARK    GeneRIF: A dual-acting DNASE1/DNASE1L3 biologic prevents
            autoimmunity and death in genetic and induced lupus models.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 284)
  AUTHORS   Willemsen,J.F., Wenskus,J., Lenz,M., Rhode,H., Trochimiuk,M.,
            Appl,B., Pagarol-Raluy,L., Bornigen,D., Bang,C., Reinshagen,K.,
            Herrmann,M., Elrod,J. and Boettcher,M.
  TITLE     DNases improve effectiveness of antibiotic treatment in murine
            polymicrobial sepsis
  JOURNAL   Front Immunol 14, 1254838 (2024)
   PUBMED   38259485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 284)
  AUTHORS   Elrod,J., Heuer,A., Knopf,J., Schoen,J., Schonfeld,L.,
            Trochimiuk,M., Stiel,C., Appl,B., Raluy,L.P., Saygi,C., Zlatar,L.,
            Hosari,S., Royzman,D., Winkler,T.H., Lochnit,G., Leppkes,M.,
            Grutzmann,R., Schett,G., Tomuschat,C., Reinshagen,K., Herrmann,M.,
            Fuchs,T.A. and Boettcher,M.
  TITLE     Neutrophil extracellular traps and DNases orchestrate formation of
            peritoneal adhesions
  JOURNAL   iScience 26 (12), 108289 (2023)
   PUBMED   38034352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 284)
  AUTHORS   Napirei,M., Karsunky,H., Zevnik,B., Stephan,H., Mannherz,H.G. and
            Moroy,T.
  TITLE     Features of systemic lupus erythematosus in Dnase1-deficient mice
  JOURNAL   Nat Genet 25 (2), 177-181 (2000)
   PUBMED   10835632
REFERENCE   7  (residues 1 to 284)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   8  (residues 1 to 284)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 284)
  AUTHORS   Takeshita,H., Yasuda,T., Nakajima,T., Hosomi,O., Nakashima,Y. and
            Kishi,K.
  TITLE     Mouse deoxyribonuclease I (DNase I): biochemical and immunological
            characterization, cDNA structure and tissue distribution
  JOURNAL   Biochem Mol Biol Int 42 (1), 65-75 (1997)
   PUBMED   9192086
REFERENCE   10 (residues 1 to 284)
  AUTHORS   Peitsch,M.C., Irmler,M., French,L.E. and Tschopp,J.
  TITLE     Genomic organisation and expression of mouse deoxyribonuclease I
  JOURNAL   Biochem Biophys Res Commun 207 (1), 62-68 (1995)
   PUBMED   7857306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087900.19.
            
            On Oct 21, 2017 this sequence version replaced XP_006521837.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83038.1, SRR5189673.149057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.37 cM"
     Protein         1..284
                     /product="deoxyribonuclease-1 precursor"
                     /EC_number="3.1.21.1"
                     /note="deoxyribonuclease-1"
                     /calculated_mol_wt=29666
     sig_peptide     1..22
                     /note="/evidence=ECO:0000250|UniProtKB:P00639; propagated
                     from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=2380
     Region          20..282
                     /region_name="DNaseIc"
                     /note="deoxyribonuclease I; smart00476"
                     /db_xref="CDD:128752"
     mat_peptide     23..284
                     /product="Deoxyribonuclease-1. /id=PRO_0000007278"
                     /note="propagated from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=29666
     Site            order(29..30,32,36,61,63..65,97..98,100,133,156,159,190,
                     192,197,229,233..234,273..274)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,100,156,190,192,234,273..274)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,273)
                     /site_type="other"
                     /note="putative Mg binding site IVb [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(31,156,190,192,274)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197337"
     Site            31
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:197337"
     Site            order(32,36,63..65,97..98,100,133,156,159,190,192,197,233,
                     274)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197337"
     Site            35
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            40
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            87
                     /site_type="other"
                     /note="Nitration by tetranitromethane destroys a Ca(2+)
                     binding site and inactivates enzyme.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            89
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(121,134)
                     /site_type="other"
                     /note="Ca binding site II [ion binding]"
                     /db_xref="CDD:197337"
     Site            128
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(190,234,274)
                     /site_type="other"
                     /note="putative Mg binding site IVa [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(194,220)
                     /site_type="metal-binding"
                     /note="metal binding site III [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(223,225)
                     /site_type="other"
                     /note="Ca binding site I [ion binding]"
                     /db_xref="CDD:197337"
     CDS             1..284
                     /gene="Dnase1"
                     /gene_synonym="DNaseI; Dnl1"
                     /coded_by="NM_001357143.2:161..1015"
                     /db_xref="CCDS:CCDS27913.1"
                     /db_xref="GeneID:13419"
                     /db_xref="MGI:MGI:103157"
ORIGIN      
        1 mrytglmgtl ltlvnllqla gtlriaafni rtfgetkmsn atlsvyfvki lsrydiaviq
       61 evrdshlvav gklldelnrd kpdtyryvvs eplgrksyke qylfvyrpdq vsildsyqyd
      121 dgcepcgndt fsrepaivkf fspytevqef aivplhaapt eavseidaly dvyldvwqkw
      181 gledimfmgd fnagcsyvts sqwssirlrt spifqwlipd sadttvtsth caydrivvag
      241 allqaavvpn savpfdfqae yglsnqlaea isdhypvevt lrki
//
LOCUS       NP_001389660            2842 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 3 [Mus musculus].
ACCESSION   NP_001389660 XP_030106137
VERSION     NP_001389660.1
DBSOURCE    REFSEQ: accession NM_001402731.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2842)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2842)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2842)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2842)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2842)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2842)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2842)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2842)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2842)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2842)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Mar 21, 2022 this sequence version replaced XP_030106137.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.344327.1,
                                           SRR17784647.258728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2842
                     /product="adenomatous polyposis coli protein isoform 3"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=310750
     Region          4..55
                     /region_name="APC_N_CC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     pfam16689"
                     /db_xref="CDD:435517"
     Region          125..205
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          338..390
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          391..464
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          457..508
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          463..506
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(497,501,505,540,544,548,584,588,592)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          510..551
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          514..551
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          558..593
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          601..642
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          647..687
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          651..685
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          689..729
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          693..729
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          730..1017
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          1034..1133
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1255..>1272
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1281..1367
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1635..1658
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1660..1713
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1714..1735
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1744..1837
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1871..1945
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          2032..2051
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2223..2568
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2670..2842
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2842
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402731.1:60..8588"
                     /note="isoform 3 is encoded by transcript variant 8"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 maaasydqll kqvealkmen snlrqeledn snhltklete asnmkevlkq lqgsiedetm
       61 tsgqidller lkefnldsnf pgvklrskms lrsygsregs vssrsgecsp vpmgsfprrt
      121 fvngsrestg yleelekers llladldkee kekdwyyaql qnltkridsl pltenfslqt
      181 dmtrrqleye arqiraamee qlgtcqdmek raqrriariq qiekdilrvr qllqsqaaea
      241 erssqsrhda asheagrqhe ghgvaesnta asssgqspat rvdhetasvl sssgthsapr
      301 rltshlgtkv emvysllsml gthdkddmsr tllamsssqd scismrqsgc lplliqllhg
      361 ndkdsvllgn srgskearar asaalhniih sqpddkrgrr eirvlhlleq iraycetcwe
      421 wqeaheqgmd qdknpmpapv ehqicpavcv lmklsfdeeh rhamnelggl qaiaellqvd
      481 cemygltndh ysvtlrryag maltnltfgd vankatlcsm kgcmralvaq lksesedlqq
      541 viasvlrnls wradvnskkt lrevgsvkal mecalevkke stlksvlsal wnlsahcten
      601 kadicavdga laflvgtlty rsqtntlaii esgggilrnv ssliatnedh rqilrenncl
      661 qtllqhlksh sltivsnacg tlwnlsarnp kdqealwdmg avsmlknlih skhkmiamgs
      721 aaalrnlman rpakykdani mspgsslpsl hvrkqkalea eldaqhlset fdnidnlspk
      781 ashrskqrhk qnlygdyafd anrhddsrsd nfntgnmtvl spylnttvlp sssssrgsld
      841 ssrsekdrsl erergiglsa yhpttenagt sskrglqitt taaqiakvme evsaihtsqd
      901 drssasttef hcvaddrsaa rrssashths ntynftksen snrtcsmpya kveykrssnd
      961 slnsvtssdg ygkrgqmkps vesyseddes kfcsygqypa dlahkihsan hmddndgeld
     1021 tpinyslkys deqlnsgrqs psqnerwarp khviedeikq neqrqarsqn tsypvysent
     1081 ddkhlkfqph fgqqecvspy rsrgtsgset nrmgsshain qnvnqslcqe ddyeddkptn
     1141 yseryseeeq heeeeerptn ysikyneekh hvdqpidysl kyatdisssq kpsfsfskns
     1201 saqstkpehl spssentavp psnakrqnql rpssaqrngq tqkgttckvp sinqetiqty
     1261 cvedtpicfs rcsslsslss addeigcdqt tqeadsantl qtaevkendv trsaedpate
     1321 vpavsqnara kpsrlqasgl ssestrhnka vefssgaksp sksgaqtpks ppehyvqetp
     1381 lvfsrctsvs sldsfesrsi assvqsepcs gmvsgiisps dlpdspgqtm ppsrsktppp
     1441 ppqtvqakre vpkskvpaae kresgpkqta vnaavqrvqv lpdvdtllhf atestpdgfs
     1501 cssslsalsl depfiqkdve lrimppvqen dngneteseq peesnenqdk evekpdsekd
     1561 llddsddddi eileeciisa mptkssrkak klaqtasklp ppvarkpsql pvykllpaqn
     1621 rlqaqkhvsf tpgddvprvy cvegtpinfs tatslsdlti esppnelatg dgvragiqsg
     1681 efekrdtipt egrstddaqr gkissivtpd lddnkaeegd ilaecinsam pkgkshkpfr
     1741 vkkimdqvqq asstssgank nqvdtkkkkp tspvkpmpqn teyrtrvrkn tdskvnvnte
     1801 etfsdnkdsk kpslqtnaka fneklpnned rvrgsfalds phhytpiegt pycfsrndsl
     1861 ssldfddddv dlsrekaelr kgkeskdsea kvtcrpepns sqqaasksqa sikhpanraq
     1921 skpvlqkqpt fpqsskdgpd rgaatdeklq nfaientpvc fsrnsslssl sdidqennnn
     1981 kesepikeae pansqgepsk pqasgyapks fhvedtpvcf srnsslssls idseddllqe
     2041 cissampkkk rpsrlksese kqsprkvggi laedltldlk dlqrpdseha fspdsenfdw
     2101 kaiqegansi vsslhqaaaa aaclsrqass dsdsilslks gislgspfhl tpdqeekpft
     2161 snkgprilkp gekstleakk iesenkgikg gkkvykslit gkirsnseis sqmkqplptn
     2221 mpsisrgrtm ihipglrnss sstspvskkg pplktpasks psegpgatts prgtkpagks
     2281 elspitrqts qisgsnkgss rsgsrdstps rptqqplsrp mqspgrnsis pgrngisppn
     2341 klsqlprtss pstastkssg sgkmsytspg rqlsqqnltk qaslsknass iprsesaskg
     2401 lnqmsngngs nkkvelsrms stkssgsesd rserpalvrq stfikeapsp tlrrkleesa
     2461 sfeslspssr pdsptrsqaq tpvlspslpd mslsthpsvq aggwrklppn lsptieyndg
     2521 rptkrhdiar shsespsrlp inragtwkre hskhssslpr vstwrrtgss ssilsasses
     2581 sekakseder hvssmpaprq mkenqvptkg twrkikesdi sptgmasqsa ssgaasgaes
     2641 kpliyqmapp vsktedvwvr iedcpinnpr sgrsptgntp pvidsvsekg sssikdskdt
     2701 hgkqsvgsgs pvqtvgletr lnsfvqveap eqkgteakpg qsnpvsiaet aetciaertp
     2761 fsssssskhs spsgtvaarv tpfnynpspr kssadstsar psqiptpvst ntkkrdsktd
     2821 stessgaqsp krhsgsylvt sv
//
LOCUS       NP_001415301             275 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 1 [Mus musculus].
ACCESSION   NP_001415301 XP_011241410
VERSION     NP_001415301.1
DBSOURCE    REFSEQ: accession NM_001428372.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 275)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 275)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 275)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 275)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 275)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 275)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 275)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 275)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 275)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 275)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            On Mar 11, 2024 this sequence version replaced XP_011241410.1.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3761359.1,
                                           SRR17784648.1070180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..275
                     /product="autophagy protein 5 isoform 1"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=32271
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1Y0; propagated from
                     UniProtKB/Swiss-Prot (Q99J83.1)"
     Region          79..270
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..275
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001428372.1:298..1125"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mtddkdvlrd vwfgriptcf tlyqdeiter eaepyylllp rvsyltlvtd kvkkhfqkvm
       61 rqedvseiwf eyegtplkwh ypigllfdll asssalpwni tvhfksfpek dllhcpskda
      121 veahfmscmk eadalkhksq vinemqkkdh kqlwmglqnd rfdqfwainr klmeyppeen
      181 gfryipfriy qttterpfiq klfrpvaadg qlhtlgdllr evcpsavape dgekrsqvmi
      241 hgiepmletp lqwlsehlsy pdnflhisiv pqptd
//
LOCUS       NP_001399782             307 aa            linear   ROD 27-AUG-2025
DEFINITION  G-protein coupled receptor 35 [Mus musculus].
ACCESSION   NP_001399782 XP_006529844
VERSION     NP_001399782.1
DBSOURCE    REFSEQ: accession NM_001412853.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 307)
  AUTHORS   Gupta,R.A., Higham,J.P., Pearce,A., Urriola-Munoz,P., Barker,K.H.,
            Paine,L., Ghooraroo,J., Raine,T., Hockley,J.R.F., Rahman,T., St
            John Smith,E., Brown,A.J.H., Ladds,G., Suzuki,R. and Bulmer,D.C.
  TITLE     GPR35 agonists inhibit TRPA1-mediated colonic nociception through
            suppression of substance P release
  JOURNAL   Pain 166 (3), 596-613 (2025)
   PUBMED   39382322
REFERENCE   2  (residues 1 to 307)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   3  (residues 1 to 307)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 307)
  AUTHORS   Cheng,L., Wu,H., Cai,X., Zhang,Y., Yu,S., Hou,Y., Yin,Z., Yan,Q.,
            Wang,Q., Sun,T., Wang,G., Yuan,Y., Zhang,X., Hao,H. and Zheng,X.
  TITLE     A Gpr35-tuned gut microbe-brain metabolic axis regulates
            depressive-like behavior
  JOURNAL   Cell Host Microbe 32 (2), 227-243 (2024)
   PUBMED   38198925
  REMARK    GeneRIF: A Gpr35-tuned gut microbe-brain metabolic axis regulates
            depressive-like behavior.
REFERENCE   5  (residues 1 to 307)
  AUTHORS   Miyamoto,K., Sujino,T., Harada,Y., Ashida,H., Yoshimatsu,Y.,
            Yonemoto,Y., Nemoto,Y., Tomura,M., Melhem,H., Niess,J.H.,
            Suzuki,T., Suzuki,T., Suzuki,S., Koda,Y., Okamoto,R., Mikami,Y.,
            Teratani,T., Tanaka,K.F., Yoshimura,A., Sato,T. and Kanai,T.
  TITLE     The gut microbiota-induced kynurenic acid recruits GPR35-positive
            macrophages to promote experimental encephalitis
  JOURNAL   Cell Rep 42 (8), 113005 (2023)
   PUBMED   37590143
REFERENCE   6  (residues 1 to 307)
  AUTHORS   Ronkainen,V.P., Tuomainen,T., Huusko,J., Laidinen,S., Malinen,M.,
            Palvimo,J.J., Yla-Herttuala,S., Vuolteenaho,O. and Tavi,P.
  TITLE     Hypoxia-inducible factor 1-induced G protein-coupled receptor 35
            expression is an early marker of progressive cardiac remodelling
  JOURNAL   Cardiovasc Res 101 (1), 69-77 (2014)
   PUBMED   24095869
  REMARK    GeneRIF: Cardiac expression of GPR35 is regulated by hypoxia
            through activation of HIF-1.
REFERENCE   7  (residues 1 to 307)
  AUTHORS   Min,K.D., Asakura,M., Liao,Y., Nakamaru,K., Okazaki,H.,
            Takahashi,T., Fujimoto,K., Ito,S., Takahashi,A., Asanuma,H.,
            Yamazaki,S., Minamino,T., Sanada,S., Seguchi,O., Nakano,A.,
            Ando,Y., Otsuka,T., Furukawa,H., Isomura,T., Takashima,S.,
            Mochizuki,N. and Kitakaze,M.
  TITLE     Identification of genes related to heart failure using global gene
            expression profiling of human failing myocardium
  JOURNAL   Biochem Biophys Res Commun 393 (1), 55-60 (2010)
   PUBMED   20100464
REFERENCE   8  (residues 1 to 307)
  AUTHORS   Wang,J., Simonavicius,N., Wu,X., Swaminath,G., Reagan,J., Tian,H.
            and Ling,L.
  TITLE     Kynurenic acid as a ligand for orphan G protein-coupled receptor
            GPR35
  JOURNAL   J Biol Chem 281 (31), 22021-22028 (2006)
   PUBMED   16754668
REFERENCE   9  (residues 1 to 307)
  AUTHORS   Horikawa,Y., Oda,N., Cox,N.J., Li,X., Orho-Melander,M., Hara,M.,
            Hinokio,Y., Lindner,T.H., Mashima,H., Schwarz,P.E., del
            Bosque-Plata,L., Horikawa,Y., Oda,Y., Yoshiuchi,I., Colilla,S.,
            Polonsky,K.S., Wei,S., Concannon,P., Iwasaki,N., Schulze,J.,
            Baier,L.J., Bogardus,C., Groop,L., Boerwinkle,E., Hanis,C.L. and
            Bell,G.I.
  TITLE     Genetic variation in the gene encoding calpain-10 is associated
            with type 2 diabetes mellitus
  JOURNAL   Nat Genet 26 (2), 163-175 (2000)
   PUBMED   11017071
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):502]
REFERENCE   10 (residues 1 to 307)
  AUTHORS   O'Dowd,B.F., Nguyen,T., Marchese,A., Cheng,R., Lynch,K.R.,
            Heng,H.H., Kolakowski,L.F. Jr. and George,S.R.
  TITLE     Discovery of three novel G-protein-coupled receptor genes
  JOURNAL   Genomics 47 (2), 310-313 (1998)
   PUBMED   9479505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119846.14.
            
            On Oct 19, 2022 this sequence version replaced XP_006529844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB582890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.65 cM"
     Protein         1..307
                     /product="G-protein coupled receptor 35"
                     /note="KYNA receptor; kynurenic acid receptor"
                     /calculated_mol_wt=34021
     Site            2
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            19..39
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          35..286
                     /region_name="7tmA_GPR35-like"
                     /note="G protein-coupled receptor 35 and similar proteins,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15164"
                     /db_xref="CDD:320292"
     Region          52..77
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320292"
     Site            54..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            order(73,76..77,87..92,94..95,98,143,145..149,167,
                     170..172,174..176,178..179,229,232..233,235..236,239,
                     253..254,256..258,261,264..265)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320292"
     Region          87..117
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320292"
     Site            89..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          129..151
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320292"
     Site            130..150
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          167..196
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320292"
     Site            177..197
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          209..239
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320292"
     Site            218..238
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          254..279
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320292"
     Site            258..278
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HC97; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     Region          288..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HC97; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HC97; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HC97; propagated from
                     UniProtKB/Swiss-Prot (Q9ES90.1)"
     CDS             1..307
                     /gene="Gpr35"
                     /gene_synonym="KPG_007"
                     /coded_by="NM_001412853.1:128..1051"
                     /db_xref="GeneID:64095"
                     /db_xref="MGI:MGI:1929509"
ORIGIN      
        1 mnsttcnstl twpasvnnff iiysalllvl glllnsvalw vfcyrmhqwt etriymtnla
       61 vadlcllcsl pfvlyslkys ssdtpvcqls qgiylanrym sislvtaiav dryvavrhpl
      121 rarelrsprq aaavcvalwv ivvtslvvrw rlgmqeggfc fssqtrrnfs ttafsllgfy
      181 lplaivvfcs lqvvtvlsrr paadvgqaea tqkathmvwa nlavfvicfl plhvvltvqv
      241 slnlntcaar dtfsralsit gklsdtnccl daicyyymar efqeaskpat ssntphksqd
      301 sqilslt
//
LOCUS       NP_001334505             442 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 5 [Mus musculus].
ACCESSION   NP_001334505 XP_006517192
VERSION     NP_001334505.1
DBSOURCE    REFSEQ: accession NM_001347576.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            On Dec 1, 2016 this sequence version replaced XP_006517192.1.
            
            Transcript Variant: This variant (13) differs in the 5' UTR and
            uses an alternate in-frame splice site in the 3' coding region,
            compared to variant 3, resulting in an isoform (5) that is shorter
            than isoform 3. Variants 8 through 14 all encode isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.136013.1,
                                           SRR10662774.4523165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..442
                     /product="myocyte-specific enhancer factor 2C isoform 5"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=47825
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..442
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347576.2:404..1732"
                     /note="isoform 5 is encoded by transcript variant 13"
                     /db_xref="CCDS:CCDS84043.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv sedvdlllnq rinnsqsaqs latpvvsvat
      301 ptlpgqgmgg ypsaisttyg teyslssadl sslsgfntas alhlgsvtgw qqqhlhnmpp
      361 salsqlgdrt ttpsrypqht trheagrspv dslsscsssy dgsdredhrn efhspigltr
      421 pspderesps vkrmrlsegw at
//
LOCUS       NP_001300850            1031 aa            linear   ROD 27-AUG-2025
DEFINITION  nitric oxide synthase, inducible isoform b [Mus musculus].
ACCESSION   NP_001300850
VERSION     NP_001300850.1
DBSOURCE    REFSEQ: accession NM_001313921.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1031)
  AUTHORS   Zhao,X., Li,J., Zhang,Y., Hu,L., Wu,D., Wu,J., Lyu,R., Li,P.,
            An,G., Cui,R., Sun,T., Zhu,P., Bai,L., Jiang,C. and Zhong,C.
  TITLE     Elevated nitric oxide during colitis restrains GM-CSF production in
            ILC3 cells via suppressing an AhR-Cyp4f13-NF-kappaB axis
  JOURNAL   Nat Commun 16 (1), 5654 (2025)
   PUBMED   40593752
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1031)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1031)
  AUTHORS   Mohanty,I., Fazelinia,H., Raimo,S., Ding,H., Spruce,L.,
            Symeonidou,M., Tenopoulou,M., Ichinose,F., Yamashita,H.,
            Shimokawa,H., Masato,T., Doulias,P.T. and Ischiropoulos,H.
  TITLE     Proteomic surveys of the mouse heart unveil cardiovascular
            responses to nitric oxide/cGMP signaling deficiencies
  JOURNAL   Commun Biol 8 (1), 817 (2025)
   PUBMED   40425728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1031)
  AUTHORS   Ananth,M.R., Gardus,J.D., Huang,C., Palekar,N., Slifstein,M.,
            Zaborszky,L., Parsey,R.V., Talmage,D.A., DeLorenzo,C. and Role,L.W.
  TITLE     A central role for acetylcholine in entorhinal cortex function and
            dysfunction with age in humans and mice
  JOURNAL   Cell Rep 44 (2), 115249 (2025)
   PUBMED   39891909
REFERENCE   5  (residues 1 to 1031)
  AUTHORS   Ball,A.B., Jones,A.E., Nguyen,K.B., Rios,A., Marx,N., Hsieh,W.Y.,
            Yang,K., Desousa,B.R., Kim,K.K.O., Veliova,M., Del Mundo,Z.M.,
            Shirihai,O.S., Beninca,C., Stiles,L., Bensinger,S.J. and
            Divakaruni,A.S.
  TITLE     Pro-inflammatory macrophage activation does not require inhibition
            of oxidative phosphorylation
  JOURNAL   EMBO Rep 26 (4), 982-1002 (2025)
   PUBMED   39753784
REFERENCE   6  (residues 1 to 1031)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   7  (residues 1 to 1031)
  AUTHORS   Lowenstein,C.J., Glatt,C.S., Bredt,D.S. and Snyder,S.H.
  TITLE     Cloned and expressed macrophage nitric oxide synthase contrasts
            with the brain enzyme
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6711-6715 (1992)
   PUBMED   1379716
REFERENCE   8  (residues 1 to 1031)
  AUTHORS   Xie,Q.W., Cho,H.J., Calaycay,J., Mumford,R.A., Swiderek,K.M.,
            Lee,T.D., Ding,A., Troso,T. and Nathan,C.
  TITLE     Cloning and characterization of inducible nitric oxide synthase
            from mouse macrophages
  JOURNAL   Science 256 (5054), 225-228 (1992)
   PUBMED   1373522
REFERENCE   9  (residues 1 to 1031)
  AUTHORS   Lyons,C.R., Orloff,G.J. and Cunningham,J.M.
  TITLE     Molecular cloning and functional expression of an inducible nitric
            oxide synthase from a murine macrophage cell line
  JOURNAL   J Biol Chem 267 (9), 6370-6374 (1992)
   PUBMED   1372907
REFERENCE   10 (residues 1 to 1031)
  AUTHORS   Liew,F.Y., Li,Y., Moss,D., Parkinson,C., Rogers,M.V. and Moncada,S.
  TITLE     Resistance to Leishmania major infection correlates with the
            induction of nitric oxide synthase in murine macrophages
  JOURNAL   Eur J Immunol 21 (12), 3009-3014 (1991)
   PUBMED   1721024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ057491.1, M87039.1 and
            AL592185.35.
            
            Summary: Nitric oxide is a reactive free radical which acts as a
            biologic mediator in several processes, including neurotransmission
            and antimicrobial and antitumoral activities. This gene encodes a
            nitric oxide synthase that is inducible by a combination of
            lipopolysaccharide and certain cytokines. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) contains an alternate exon in
            place of the first two exons compared to variant 1. This difference
            results in translation initiation at a downstream start codon and
            an isoform (b) that is shorter at the N-terminus compared to
            isoform a. Variants 2 and 3 both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     Protein         1..1031
                     /product="nitric oxide synthase, inducible isoform b"
                     /EC_number="1.14.13.39"
                     /note="nitric oxide synthase, inducible; inducible nitric
                     oxide synthase; NOS type II; inducible NOS; macrophage
                     NOS; inducible NO synthase; peptidyl-cysteine
                     S-nitrosylase NOS2; nitric oxide synthase 2, inducible,
                     macrophage"
                     /calculated_mol_wt=117824
     Region          1..377
                     /region_name="NOS_oxygenase_euk"
                     /note="Nitric oxide synthase (NOS) eukaryotic oxygenase
                     domain. NOS produces nitric oxide (NO) by catalyzing a
                     five-electron heme-based oxidation of a guanidine nitrogen
                     of L-arginine to L-citrulline via two successive
                     monooxygenation reactions producing N...; cd00795"
                     /db_xref="CDD:238410"
     Site            order(81,144,228,250..251,253..254,258,262..263,343..344,
                     372)
                     /site_type="active"
                     /db_xref="CDD:238410"
     Region          422..553
                     /region_name="Flavodoxin_1"
                     /note="pfam00258"
                     /db_xref="CDD:425562"
     Region          617..1013
                     /region_name="FNR_like"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; cl06868"
                     /db_xref="CDD:447143"
     Site            order(653,787..790,805..807,823..826,865)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99778"
     Site            order(787,789..790)
                     /site_type="other"
                     /note="conserved FAD binding motif [chemical binding]"
                     /db_xref="CDD:99778"
     Site            order(823,826,829,835)
                     /site_type="other"
                     /note="phosphate binding motif [ion binding]"
                     /db_xref="CDD:99778"
     Site            order(860,864..867,869)
                     /site_type="other"
                     /note="beta-alpha-beta structure motif"
                     /db_xref="CDD:99778"
     Site            order(865..866,896..898,964..965)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99778"
     CDS             1..1031
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /coded_by="NM_001313921.1:346..3441"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="GeneID:18126"
                     /db_xref="MGI:MGI:97361"
ORIGIN      
        1 mnpksltrgp rdkptpleel lphaiefinq yygsfkeaki eehlarleav tkeiettgty
       61 qltldelifa tkmawrnapr cigriqwsnl qvfdarncst aqemfqhicr hilyatnngn
      121 irsaitvfpq rsdgkhdfrl wnsqliryag yqmpdgtirg daatleftql cidlgwkpry
      181 grfdvlplvl qadgqdpevf eippdlvlev tmehpkyewf qelglkwyal pavanmllev
      241 gglefpacpf ngwymgteig vrdfcdtqry nileevgrrm glethtlasl wkdravtein
      301 vavlhsfqkq nvtimdhhta sesfmkhmqn eyrarggcpa dwiwlvppvs gsitpvfhqe
      361 mlnyvlspfy yyqiepwkth iwqneklrpr rreirfrvlv kvvffasmlm rkvmasrvra
      421 tvlfatetgk sealardlat lfsyafntkv vcmdqykast leeeqlllvv tstfgngdcp
      481 sngqtlkksl fmlrelnhtf ryavfglgss mypqfcafah didqklshlg asqlaptgeg
      541 delsgqedaf rswavqtfra acetfdvrsk hhiqipkrft snatwepqqy rliqspepld
      601 lnralssiha knvftmrlks qqnlqsekss rttllvqltf egsrgpsylp gehlgifpgn
      661 qtalvqgile rvvdcptphq tvclevldes gsywvkdkrl ppcslsqalt yfldittppt
      721 qlqlhklarf atdetdrqrl ealcqpseyn dwkfsnnptf levleefpsl hvpaafllsq
      781 lpilkpryys isssqdhtps evhltvavvt yrtrdgqgpl hhgvcstwir nlkpqdpvpc
      841 fvrsvsgfql pedpsqpcil igpgtgiapf rsfwqqrlhd sqhkglkggr mslvfgcrhp
      901 eedhlyqeem qemvrkrvlf qvhtgysrlp gkpkvyvqdi lqkqlanevl svlhgeqghl
      961 yicgdvrmar dvattlkklv atklnlseeq vedyffqlks qkryhedifg avfsygakkg
     1021 saleepkatr l
//
LOCUS       NP_777276                535 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon lambda receptor 1 precursor [Mus musculus].
ACCESSION   NP_777276
VERSION     NP_777276.3
DBSOURCE    REFSEQ: accession NM_174851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 535)
  AUTHORS   Song,J., Zhang,L., Moon,S., Fang,A., Wang,G., Gheshm,N., Loeb,S.A.,
            Cao,P., Wallace,J.R., Alfajaro,M.M., Strine,M.S., Beatty,W.L.,
            Jamieson,A.M., Orchard,R.C., Robinson,B.A., Nice,T.J., Wilen,C.B.,
            Orvedahl,A., Reese,T.A. and Lee,S.
  TITLE     Norovirus co-opts NINJ1 for selective protein secretion
  JOURNAL   Sci Adv 11 (9), eadu7985 (2025)
   PUBMED   40020060
REFERENCE   2  (residues 1 to 535)
  AUTHORS   Ramirez Reyes,B., Madden,S., Meyer,K.A., Bartsch,B., Wright,A.P.,
            Constant,D.A. and Nice,T.J.
  TITLE     Homeostatic antiviral protection of the neonatal gut epithelium by
            interferon lambda
  JOURNAL   Cell Rep 44 (2), 115243 (2025)
   PUBMED   39893635
REFERENCE   3  (residues 1 to 535)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   4  (residues 1 to 535)
  AUTHORS   Alippe,Y., Wang,L., Coskun,R., Muraro,S.P., Zhao,F.R.,
            Elam-Noll,M., White,J.M., Vota,D.M., Hauk,V.C., Gordon,J.I.,
            Handley,S.A. and Diamond,M.S.
  TITLE     Fetal MAVS and type I IFN signaling pathways control ZIKV infection
            in the placenta and maternal decidua
  JOURNAL   J Exp Med 221 (9) (2024)
   PUBMED   39042188
REFERENCE   5  (residues 1 to 535)
  AUTHORS   Ashby,K.M., Voboril,M., Salgado,O.C., Lee,S.T., Martinez,R.J.,
            O'Connor,C.H., Breed,E.R., Xuan,S., Roll,C.R., Bachigari,S.,
            Heiland,H., Stetson,D.B., Kotenko,S.V. and Hogquist,K.A.
  TITLE     Sterile production of interferons in the thymus affects T cell
            repertoire selection
  JOURNAL   Sci Immunol 9 (97), eadp1139 (2024)
   PUBMED   39058762
REFERENCE   6  (residues 1 to 535)
  AUTHORS   Frieman,M.B., Chen,J., Morrison,T.E., Whitmore,A., Funkhouser,W.,
            Ward,J.M., Lamirande,E.W., Roberts,A., Heise,M., Subbarao,K. and
            Baric,R.S.
  TITLE     SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type
            I, II and III interferon receptor independent mechanism
  JOURNAL   PLoS Pathog 6 (4), e1000849 (2010)
   PUBMED   20386712
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 535)
  AUTHORS   Mordstein,M., Kochs,G., Dumoutier,L., Renauld,J.C., Paludan,S.R.,
            Klucher,K. and Staeheli,P.
  TITLE     Interferon-lambda contributes to innate immunity of mice against
            influenza A virus but not against hepatotropic viruses
  JOURNAL   PLoS Pathog 4 (9), e1000151 (2008)
   PUBMED   18787692
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 535)
  AUTHORS   Ank,N., Iversen,M.B., Bartholdy,C., Staeheli,P., Hartmann,R.,
            Jensen,U.B., Dagnaes-Hansen,F., Thomsen,A.R., Chen,Z., Haugen,H.,
            Klucher,K. and Paludan,S.R.
  TITLE     An important role for type III interferon (IFN-lambda/IL-28) in
            TLR-induced antiviral activity
  JOURNAL   J Immunol 180 (4), 2474-2485 (2008)
   PUBMED   18250457
REFERENCE   9  (residues 1 to 535)
  AUTHORS   Lasfar,A., Lewis-Antes,A., Smirnov,S.V., Anantha,S., Abushahba,W.,
            Tian,B., Reuhl,K., Dickensheets,H., Sheikh,F., Donnelly,R.P.,
            Raveche,E. and Kotenko,S.V.
  TITLE     Characterization of the mouse IFN-lambda ligand-receptor system:
            IFN-lambdas exhibit antitumor activity against B16 melanoma
  JOURNAL   Cancer Res 66 (8), 4468-4477 (2006)
   PUBMED   16618774
REFERENCE   10 (residues 1 to 535)
  AUTHORS   Kotenko,S.V., Gallagher,G., Baurin,V.V., Lewis-Antes,A., Shen,M.,
            Shah,N.K., Langer,J.A., Sheikh,F., Dickensheets,H. and
            Donnelly,R.P.
  TITLE     IFN-lambdas mediate antiviral protection through a distinct class
            II cytokine receptor complex
  JOURNAL   Nat Immunol 4 (1), 69-77 (2003)
   PUBMED   12483210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662911.21.
            
            On Mar 21, 2009 this sequence version replaced NP_777276.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057856.1, AK141338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 67.94 cM"
     Protein         1..535
                     /product="interferon lambda receptor 1 precursor"
                     /note="class II cytokine receptor 12; interleukin-28
                     receptor subunit alpha; IL-28RA; IL-28R-alpha; IFN-lambda
                     R1; IL-28 receptor subunit alpha; cytokine receptor
                     class-II member 12; cytokine receptor family 2 member 12;
                     interleukin 28 receptor alpha"
                     /calculated_mol_wt=57637
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2358
     Region          16..109
                     /region_name="Tissue_fac"
                     /note="Tissue factor; pfam01108"
                     /db_xref="CDD:460067"
     mat_peptide     21..535
                     /product="Interferon lambda receptor 1.
                     /id=PRO_0000011020"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGK5.1)"
                     /calculated_mol_wt=57637
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Site            36
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Site            52
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Site            141
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Site            228..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Region          248..298
                     /region_name="JAK1bd_box_IFNLR1"
                     /note="JAK1 binding box domain found in interferon lambda
                     receptor 1 (IFNLR1) and similar proteins; cd21910"
                     /db_xref="CDD:439315"
     Site            order(251,254..258,261..269,271,273,275..279,281,283..284,
                     286..294)
                     /site_type="other"
                     /note="JAK1 binding site [polypeptide binding]"
                     /db_xref="CDD:439315"
     Region          301..419
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGK5.1)"
     Region          478..520
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CGK5.1)"
     CDS             1..535
                     /gene="Ifnlr1"
                     /gene_synonym="CRF2-12; Il28ra"
                     /coded_by="NM_174851.4:341..1948"
                     /db_xref="CCDS:CCDS18788.1"
                     /db_xref="GeneID:242700"
                     /db_xref="MGI:MGI:2429859"
ORIGIN      
        1 mwradrwapl llfllqsalg rprlapprnv tlfsqnftvy ltwlpglgsp pnvtyfvtyq
       61 syiktgwrpv ehcagikalv cplmclkkln lyskfkgrvq aasahgrspr vesryleylf
      121 dvelapptlv ltqmekilrv natyqlppcm pslelkyqve fwkeglgskt lfpdtpygqp
      181 vqiplqqgas rrhclsartv ytlidikysq fsepscifle apgdkravla mpslllllia
      241 avaagvawki mkgnpwfqgv ktpraldfse yrypvatfqp sgpefsddli lcpqkeltir
      301 nrpapqvrnp atlqagperd stedededtd ydddgdsvqp ylerplfise kprvmehset
      361 desgvdsggp wtspvgsdgs sawdssdrsw sstgdssykd evgssscldr kepdqapcgd
      421 wlqealpcle fsedlgtvee plkdglsgwr isgslsskrd lapveppvsl qtltfcwvnn
      481 pegeeeqede eeeeeeeeee dwesepkgsn agcwgtssvq rtevrgrmlg dylvr
//
LOCUS       NP_001165584             669 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRAF7 isoform 1 [Mus musculus].
ACCESSION   NP_001165584
VERSION     NP_001165584.1
DBSOURCE    REFSEQ: accession NM_001172113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 669)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 669)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Paterno,R.,
            Sherry,D.M., Johnson,A.C. and Dunn,I.F.
  TITLE     Spontaneous mutation in 2310061I04Rik results in reduced expression
            of mitochondrial genes and impaired brain myelination
  JOURNAL   PLoS One 19 (12), e0290487 (2024)
   PUBMED   39631040
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 669)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 669)
  AUTHORS   Tsitsikov,E.N., Phan,K.P., Liu,Y., Tsytsykova,A.V., Kinter,M.,
            Selland,L., Garman,L., Griffin,C. and Dunn,I.F.
  TITLE     TRAF7 is an essential regulator of blood vessel integrity during
            mouse embryonic and neonatal development
  JOURNAL   iScience 26 (8), 107474 (2023)
   PUBMED   37583551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 669)
  AUTHORS   Zotti,T., Vito,P. and Stilo,R.
  TITLE     The seventh ring: exploring TRAF7 functions
  JOURNAL   J Cell Physiol 227 (3), 1280-1284 (2012)
   PUBMED   22105767
  REMARK    GeneRIF: TRAF7 is involved in signal transduction pathways that
            lead either to activation or repression of NF-kappaB transcription
            factor.
            Review article
REFERENCE   6  (residues 1 to 669)
  AUTHORS   Tsikitis,M., Acosta-Alvear,D., Blais,A., Campos,E.I., Lane,W.S.,
            Sanchez,I. and Dynlacht,B.D.
  TITLE     Traf7, a MyoD1 transcriptional target, regulates nuclear
            factor-kappaB activity during myogenesis
  JOURNAL   EMBO Rep 11 (12), 969-976 (2010)
   PUBMED   20948544
  REMARK    GeneRIF: These results suggest a new mechanism by which MyoD1
            function is coupled to NF-kappaB activity through Traf7, regulating
            the balance between cell cycle progression and differentiation
            during myogenesis.
REFERENCE   7  (residues 1 to 669)
  AUTHORS   Morita,Y., Kanei-Ishii,C., Nomura,T. and Ishii,S.
  TITLE     TRAF7 sequesters c-Myb to the cytoplasm by stimulating its
            sumoylation
  JOURNAL   Mol Biol Cell 16 (11), 5433-5444 (2005)
   PUBMED   16162816
  REMARK    GeneRIF: TRAF7 negatively regulates c-Myb activity by sequestering
            c-Myb to the cytosol via sumoylation.
REFERENCE   8  (residues 1 to 669)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132367.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3324620.1,
                                           SRR13422590.84788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.4 cM"
     Protein         1..669
                     /product="E3 ubiquitin-protein ligase TRAF7 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="ring finger and WD repeat domain 1; E3
                     ubiquitin-protein ligase TRAF7; RING-type E3 ubiquitin
                     transferase TRAF7"
                     /calculated_mol_wt=74325
     Region          123..167
                     /region_name="mRING-HC-C3HC3D_TRAF7"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in tumor necrosis factor (TNF) receptor-associated
                     factor 7 (TRAF7) and similar proteins; cd16644"
                     /db_xref="CDD:438306"
     Region          207..>268
                     /region_name="Sina"
                     /note="Seven in absentia protein family; pfam03145"
                     /db_xref="CDD:460824"
     Region          281..321
                     /region_name="DD_cGKI"
                     /note="Dimerization/Docking domain of Cyclic GMP-dependent
                     Protein Kinase I; cl17044"
                     /db_xref="CDD:473057"
     Region          282..>372
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Site            order(282..283,286,289..290,293..294,297,300..301,304,
                     307..308,311,314..315,318..319,321)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:213373"
     Site            order(298..299,301,303)
                     /site_type="other"
                     /note="putative GKAP docking site [polypeptide binding]"
                     /db_xref="CDD:213373"
     Region          <386..667
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          442..476
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          481..516
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          526..555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..595
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          603..638
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          645..667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..669
                     /gene="Traf7"
                     /gene_synonym="RFWD1"
                     /coded_by="NM_001172113.2:135..2144"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50014.1"
                     /db_xref="GeneID:224619"
                     /db_xref="MGI:MGI:3042141"
ORIGIN      
        1 mssaksaryd rfsggpanlp ssdssgtrme ttfgptfstv ttitkadgtg tykqhrrtps
       61 ssstlayspr deedgmppin tprrsdsais vrslhsessm slrstfslpe eeeepeplvf
      121 aeqpsvklcc qlccsvfkdp vittcghtfc rrcalksekc pvdnakltvv vnniavaeqi
      181 gelfihcrhg chaagtgkpg vfevdprgcp ftiklsarkd hesscdyrpv rcpnnpscpp
      241 llkmnleahl kecehikcph skygctfign qdtyethlet crfeglkefl qqtddrfhem
      301 hvalaqkdqe iaflrsmlgk lsekidqlek slelkfdvld enqsklsedl mefrrdasml
      361 ndelshinar lnmgilgsyd pqqifkckgt fvghqgpvwc lcvysmgdll fsgssdktik
      421 vwdtcttykc qktleghdgi vlalciqgck lysgsadcti ivwdiqnlqk vntirahdnp
      481 vctlvsshnm lfsgslkaik vwdivgtelk lkkeltglnh wvralvaaqs ylysgsyqti
      541 kiwdirtldc ihvlqtsggs vysiavtnhh ivcgtyenli hvwdieskeq vrtltghvgt
      601 vyalavistp dqtkvfsasy drslrvwsmd nmictqtllr hqgsvtalav srgrlfsgav
      661 dstvkvwtc
//
LOCUS       NP_001398580             883 aa            linear   ROD 27-AUG-2025
DEFINITION  autotaxin isoform 5 [Mus musculus].
ACCESSION   NP_001398580 XP_036015146
VERSION     NP_001398580.1
DBSOURCE    REFSEQ: accession NM_001411651.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 883)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 883)
  AUTHORS   Dacheux,M.A., Norman,D.D., Shin,Y., Tigyi,G.J. and Lee,S.C.
  TITLE     Deleting autotaxin in LysM+ myeloid cells impairs innate tumor
            immunity in models of metastatic melanoma
  JOURNAL   iScience 27 (10), 110971 (2024)
   PUBMED   39398245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 883)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   4  (residues 1 to 883)
  AUTHORS   Petersen-Cherubini,C.L., Liu,Y., Deffenbaugh,J.L., Murphy,S.P.,
            Xin,M., Rau,C.N., Yang,Y. and Lovett-Racke,A.E.
  TITLE     Dysregulated autotaxin expression by T cells in multiple sclerosis
  JOURNAL   J Neuroimmunol 387, 578282 (2024)
   PUBMED   38183947
  REMARK    GeneRIF: Dysregulated autotaxin expression by T cells in multiple
            sclerosis.
REFERENCE   5  (residues 1 to 883)
  AUTHORS   Giganti,A., Rodriguez,M., Fould,B., Moulharat,N., Coge,F.,
            Chomarat,P., Galizzi,J.P., Valet,P., Saulnier-Blache,J.S.,
            Boutin,J.A. and Ferry,G.
  TITLE     Murine and human autotaxin alpha, beta, and gamma isoforms: gene
            organization, tissue distribution, and biochemical characterization
  JOURNAL   J Biol Chem 283 (12), 7776-7789 (2008)
   PUBMED   18175805
  REMARK    GeneRIF: Murine and human autotaxin alpha, beta, and gamma
            isoforms: gene organization, tissue distribution, and biochemical
            characterization.
REFERENCE   6  (residues 1 to 883)
  AUTHORS   Koike,S., Keino-Masu,K., Ohto,T. and Masu,M.
  TITLE     The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions
            as a signal peptide
  JOURNAL   Genes Cells 11 (2), 133-142 (2006)
   PUBMED   16436050
REFERENCE   7  (residues 1 to 883)
  AUTHORS   Jansen,S., Stefan,C., Creemers,J.W., Waelkens,E., Van Eynde,A.,
            Stalmans,W. and Bollen,M.
  TITLE     Proteolytic maturation and activation of autotaxin (NPP2), a
            secreted metastasis-enhancing lysophospholipase D
  JOURNAL   J Cell Sci 118 (Pt 14), 3081-3089 (2005)
   PUBMED   15985467
REFERENCE   8  (residues 1 to 883)
  AUTHORS   Bachner,D., Ahrens,M., Betat,N., Schroder,D. and Gross,G.
  TITLE     Developmental expression analysis of murine autotaxin (ATX)
  JOURNAL   Mech Dev 84 (1-2), 121-125 (1999)
   PUBMED   10473125
REFERENCE   9  (residues 1 to 883)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (residues 1 to 883)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123644.8.
            
            On Aug 30, 2022 this sequence version replaced XP_036015146.1.
            
            Summary: This gene encodes a member of the phosphodiesterase and
            nucleotide pyrophosphatase family of bifunctional enzymes that
            hydrolize phosphodiester bonds of various nucleotides. The encoded
            protein undergoes proteolytic processing to generate a mature
            protein with lysophospholipase D activity, catalyzing the cleavage
            of the choline group from lysophosphatidylcholine to produce
            lysophosphatidic acid. This gene is expressed in numerous tissues
            and participates in neural development, obesity, inflammation and
            oncogenesis. A complete lack of the encoded protein in mice results
            in aberrant vascular and neuronal development leading to embryonic
            lethality. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice site, lacks an in-frame exon, and contains an alternate
            in-frame exon in the central coding region, compared to variant 1.
            The encoded isoform (5) is shorter, compared to isoform 1. This
            isoform (5) may undergo proteolytic processing similar to isoform
            2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.129841.1,
                                           SRR1660817.91328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.6 cM"
     Protein         1..883
                     /product="autotaxin isoform 5"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; autotaxin; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2"
                     /calculated_mol_wt=101095
     Region          56..97
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          98..141
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          165..477
                     /region_name="Phosphodiest"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; pfam01663"
                     /db_xref="CDD:396300"
     Site            order(171,208..209,230,311,315,358..359,474)
                     /site_type="active"
                     /db_xref="CDD:293742"
     Site            order(171,208..209,230,311,315,359,474)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293742"
     Site            499..501
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:293742"
     Region          635..865
                     /region_name="NUC"
                     /note="DNA/RNA non-specific endonuclease; smart00477"
                     /db_xref="CDD:214683"
     Site            order(697..698,700,737,741)
                     /site_type="active"
                     /db_xref="CDD:238043"
     Site            order(697..698,741)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238043"
     CDS             1..883
                     /gene="Enpp2"
                     /gene_synonym="ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha;
                     Pdnp2"
                     /coded_by="NM_001411651.1:58..2709"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:18606"
                     /db_xref="MGI:MGI:1321390"
ORIGIN      
        1 marqgcfgsy qvislftfai gvnlclgfta srikraewde gpptvlsdsp wtntsgsckg
       61 rcfelqevgp pdcrcdnlck sysscchdfd elclktargw ectkdrcgev rneenachcs
      121 edclsrgdcc tnyqvvckge shwvdddcee irvpecpagf vrppliifsv dgfrasymkk
      181 gskvmpniek lrscgthapy mrpvyptktf pnlytlatgl ypeshgivgn smydpvfdat
      241 fhlrgrekfn hrwwggqplw itatkqgvra gtffwsvsip herriltilq wlslpdnerp
      301 svyafyseqp dfsghkygpf gpemtnplre idktvgqlmd glkqlklhrc vnvifvgdhg
      361 medvtcdrte flsnyltnvd ditlvpgtlg rirpkipnnl kydpkaiian ltckkpdqhf
      421 kpymkqhlpk rlhyannrri edlhllverr whvarkpldv ykkpsgkcff qgdhgfdnkv
      481 nsmqtvfvgy gptfkyrtkv ppfenielyn vmcdllglkp apnngthgsl nhllrtntfr
      541 ptlpeevsrp nypgimylqs dfdlgctcdd knkleelnkr lhtkgsteae tgkfrgskhe
      601 nkkslngnve prkerhllyg rpavlyrtsy dilyhtdfes gyseiflmpl wtsytiskqa
      661 evssipehlt ncvrpdvrvs pgfsqnclay kndkqmsygf lfppylsssp eakydaflvt
      721 nmvpmypafk rvwtyfqrvl vkkyaserng vnvisgpifd ynynglrdie deikqyvegs
      781 sipvpthyys iitscldftq padkcdgpls vssfilphrp dndescnsse deskwveelm
      841 kmhtarvrdi ehltgldfyr ktsrsyseil tlktylhtye sei
//
LOCUS       NP_001371256             147 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin regulatory light chain 2, ventricular/cardiac muscle isoform
            isoform 2 [Mus musculus].
ACCESSION   NP_001371256
VERSION     NP_001371256.1
DBSOURCE    REFSEQ: accession NM_001384327.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Xu,F., Huang,H., Peng,K., Jian,C., Wu,H., Jing,Z., Qiu,S., Chen,Y.,
            Liu,K., Fu,L., Wang,Y., Yang,J., Duan,X., Wang,C., Cheng,H. and
            Wang,X.
  TITLE     ROMO1 overexpression protects the mitochondrial cysteinome from
            oxidations in aging
  JOURNAL   Nat Commun 16 (1), 5133 (2025)
   PUBMED   40461459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Sheikh,F., Lyon,R.C. and Chen,J.
  TITLE     Functions of myosin light chain-2 (MYL2) in cardiac muscle and
            disease
  JOURNAL   Gene 569 (1), 14-20 (2015)
   PUBMED   26074085
  REMARK    Review article
            Erratum:[Gene. 2015 Oct 15;571(1):151]
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Lee,K.F., Simon,H., Chen,H., Bates,B., Hung,M.C. and Hauser,C.
  TITLE     Requirement for neuregulin receptor erbB2 in neural and cardiac
            development
  JOURNAL   Nature 378 (6555), 394-398 (1995)
   PUBMED   7477377
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Lee,K.J., Ross,R.S., Rockman,H.A., Harris,A.N., O'Brien,T.X., van
            Bilsen,M., Shubeita,H.E., Kandolf,R., Brem,G., Price,J. et al.
  TITLE     Myosin light chain-2 luciferase transgenic mice reveal distinct
            regulatory programs for cardiac and skeletal muscle-specific
            expression of a single contractile protein gene
  JOURNAL   J Biol Chem 267 (22), 15875-15885 (1992)
   PUBMED   1379240
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Hastings,K.E. and Emerson,C.P. Jr.
  TITLE     cDNA clone analysis of six co-regulated mRNAs encoding skeletal
            muscle contractile proteins
  JOURNAL   Proc Natl Acad Sci U S A 79 (5), 1553-1557 (1982)
   PUBMED   6951196
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Czosnek,H., Nudel,U., Shani,M., Barker,P.E., Pravtcheva,D.D.,
            Ruddle,F.H. and Yaffe,D.
  TITLE     The genes coding for the muscle contractile proteins, myosin heavy
            chain, myosin light chain 2, and skeletal muscle actin are located
            on three different mouse chromosomes
  JOURNAL   EMBO J 1 (11), 1299-1305 (1982)
   PUBMED   6897916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140353.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.120198.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     Protein         1..147
                     /product="myosin regulatory light chain 2,
                     ventricular/cardiac muscle isoform isoform 2"
                     /note="myosin light chain 2v; myosin light chain,
                     phosphorylatable, cardiac ventricles"
                     /calculated_mol_wt=16716
     Region          1..141
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..147
                     /gene="Myl2"
                     /gene_synonym="Gm32672; MLC-2; MLC-2s/v; MLC-2v; Mlc2v;
                     Mylpc"
                     /coded_by="NM_001384327.1:889..1332"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:17906"
                     /db_xref="MGI:MGI:97272"
ORIGIN      
        1 mfeqtqiqef keaftimdqn rdgfidkndl rdtfaalgrv nvkneeidem ikeapgpinf
       61 tvfltmfgek lkgadpeeti lnafkvfdpe gkgslkadyv remlttqaer fskeeidqmf
      121 aafppdvtgn ldyknlvhii thgeekd
//
LOCUS       NP_075618                 52 aa            linear   ROD 27-AUG-2025
DEFINITION  phospholamban [Mus musculus].
ACCESSION   NP_075618
VERSION     NP_075618.1
DBSOURCE    REFSEQ: accession NM_023129.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 52)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 52)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 52)
  AUTHORS   Klocke,B., Britzolaki,A., Saurine,J., Ott,H., Krone,K.,
            Bahamonde,K., Thelen,C., Tzimas,C., Sanoudou,D., Kranias,E.G. and
            Pitychoutis,P.M.
  TITLE     A novel role for phospholamban in the thalamic reticular nucleus
  JOURNAL   Sci Rep 14 (1), 6376 (2024)
   PUBMED   38493225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 52)
  AUTHORS   Stege,N.M., Oliveira Nunes Teixeira,V., Zijlstra,S.N.,
            Feringa,A.M., de Boer,R.A. and Sillje,H.H.W.
  TITLE     Deletion of DWORF does not affect cardiac function in aging and in
            PLN-R14del cardiomyopathy
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (3), H870-H876 (2024)
   PUBMED   38334971
REFERENCE   5  (residues 1 to 52)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   6  (residues 1 to 52)
  AUTHORS   Kadambi,V.J., Ponniah,S., Harrer,J.M., Hoit,B.D., Dorn,G.W. 2nd,
            Walsh,R.A. and Kranias,E.G.
  TITLE     Cardiac-specific overexpression of phospholamban alters calcium
            kinetics and resultant cardiomyocyte mechanics in transgenic mice
  JOURNAL   J Clin Invest 97 (2), 533-539 (1996)
   PUBMED   8567978
REFERENCE   7  (residues 1 to 52)
  AUTHORS   Hoit,B.D., Khoury,S.F., Kranias,E.G., Ball,N. and Walsh,R.A.
  TITLE     In vivo echocardiographic detection of enhanced left ventricular
            function in gene-targeted mice with phospholamban deficiency
  JOURNAL   Circ Res 77 (3), 632-637 (1995)
   PUBMED   7641333
REFERENCE   8  (residues 1 to 52)
  AUTHORS   Koss,K.L., Ponniah,S., Jones,W.K., Grupp,I.L. and Kranias,E.G.
  TITLE     Differential phospholamban gene expression in murine cardiac
            compartments. Molecular and physiological analyses
  JOURNAL   Circ Res 77 (2), 342-353 (1995)
   PUBMED   7542181
  REMARK    Erratum:[Circ Res 1995 Nov;77(5):1036]
REFERENCE   9  (residues 1 to 52)
  AUTHORS   Luo,W., Grupp,I.L., Harrer,J., Ponniah,S., Grupp,G., Duffy,J.J.,
            Doetschman,T. and Kranias,E.G.
  TITLE     Targeted ablation of the phospholamban gene is associated with
            markedly enhanced myocardial contractility and loss of beta-agonist
            stimulation
  JOURNAL   Circ Res 75 (3), 401-409 (1994)
   PUBMED   8062415
REFERENCE   10 (residues 1 to 52)
  AUTHORS   Ganim,J.R., Luo,W., Ponniah,S., Grupp,I., Kim,H.W., Ferguson,D.G.,
            Kadambi,V., Neumann,J.C., Doetschman,T. and Kranias,E.G.
  TITLE     Mouse phospholamban gene expression during development in vivo and
            in vitro
  JOURNAL   Circ Res 71 (5), 1021-1030 (1992)
   PUBMED   1394867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658675.1, AK002622.1 and BM123812.2.
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB658675.1, AK002622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..52
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 27.11 cM"
     Protein         1..52
                     /product="phospholamban"
                     /note="cardiac phospholamban"
                     /calculated_mol_wt=5963
     Region          1..52
                     /region_name="P_lamban"
                     /note="phospholamban; TIGR01294"
                     /db_xref="CDD:273541"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:A4IFH6; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:20890288,
                     ECO:0000269|PubMed:22971924, ECO:0000269|PubMed:26644582,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CaMK2.
                     /evidence=ECO:0000250|UniProtKB:P61012; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            32..52
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P61014.1)"
     CDS             1..52
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /coded_by="NM_023129.5:218..376"
                     /db_xref="CCDS:CCDS35899.1"
                     /db_xref="GeneID:18821"
                     /db_xref="MGI:MGI:97622"
ORIGIN      
        1 mekvqyltrs airrastiem pqqarqnlqn lfinfclili cllliciivm ll
//
LOCUS       NP_001408085             372 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform i [Mus musculus].
ACCESSION   NP_001408085 XP_030109112
VERSION     NP_001408085.1
DBSOURCE    REFSEQ: accession NM_001421156.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 372)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109112.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.3355397.1,
                                           SRR7345562.1230344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..372
                     /product="ELAV-like protein 4 isoform i"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40748
     Region          48..371
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..372
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421156.1:368..1486"
                     /note="isoform i is encoded by transcript variant 12"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mewnglkmii stmepqvsng ptsntsngps snnrncpspm qtgaatddsk tnlivnylpq
       61 nmtqeefrsl fgsigeiesc klvrdkitgq slgygfvnyi dpkdaekain tlnglrlqtk
      121 tikvsyarps sasirdanly vsglpktmtq keleqlfsqy griitsrilv dqvtgvsrgv
      181 gfirfdkrie aeeaikglng qkpsgatepi tvkfannpsq kssqallsql yqspnrrypg
      241 plhhqaqrfr lmsgpvppsa cpprfspiti dgmtslvgmn ipghtgtgwc ifvynlspds
      301 desvlwqlfg pfgavnnvkv irdfntnkck gfgfvtmtny deaamaiasl ngyrlgdrvl
      361 qvsfktnkah ks
//
LOCUS       NP_001346081             383 aa            linear   ROD 27-AUG-2025
DEFINITION  recombining binding protein suppressor of hairless isoform 5 [Mus
            musculus].
ACCESSION   NP_001346081 XP_017176232
VERSION     NP_001346081.1
DBSOURCE    REFSEQ: accession NM_001359152.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 383)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   2  (residues 1 to 383)
  AUTHORS   Chen,K.Y., Kibayashi,T., Giguelay,A., Hata,M., Nakajima,S.,
            Mikami,N., Takeshima,Y., Ichiyama,K., Omiya,R., Ludwig,L.S.,
            Hattori,K. and Sakaguchi,S.
  TITLE     Genome-wide CRISPR screen in human T cells reveals regulators of
            FOXP3
  JOURNAL   Nature 642 (8066), 191-200 (2025)
   PUBMED   40140585
  REMARK    Erratum:[Nature. 2025 Jul;643(8074):E25. doi:
            10.1038/s41586-025-09356-6. PMID: 40640568]
REFERENCE   3  (residues 1 to 383)
  AUTHORS   O'Hara,J., Dakle,P., Nguyen,M.L.T., Barugahare,A., Bennett,T.J.,
            Udupa,V.A., Murray,N., Schlegel,G., Kapouleas,C., Li,J.,
            Turner,S.J. and Russ,B.E.
  TITLE     Notch dependent chromatin remodeling enables Gata3 binding and
            drives lineage specific CD8+ T cell function
  JOURNAL   Immunol Cell Biol 103 (4), 365-382 (2025)
   PUBMED   40012375
REFERENCE   4  (residues 1 to 383)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   5  (residues 1 to 383)
  AUTHORS   Nakisli,S., Fanelli,K., LaComb,J., Arnold,L.J. and Nielsen,C.M.
  TITLE     CNS resident macrophages exhibit region-specific states and
            immunogenic responses during Rbpj-deficient brain arteriovenous
            malformation
  JOURNAL   Sci Rep 15 (1), 3932 (2025)
   PUBMED   39890825
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 383)
  AUTHORS   Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and
            Israel,A.
  TITLE     Signalling downstream of activated mammalian Notch
  JOURNAL   Nature 377 (6547), 355-358 (1995)
   PUBMED   7566092
REFERENCE   7  (residues 1 to 383)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
REFERENCE   8  (residues 1 to 383)
  AUTHORS   Hamaguchi,Y., Mastunami,N., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     Cloning and characterization of a protein binding to the J kappa
            recombination signal sequence of immunoglobulin genes
  JOURNAL   Adv Exp Med Biol 292, 177-186 (1991)
   PUBMED   1950768
REFERENCE   9  (residues 1 to 383)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
REFERENCE   10 (residues 1 to 383)
  AUTHORS   Siminovitch,K.A., Moore,M.W., Durdik,J. and Selsing,E.
  TITLE     The human kappa deleting element and the mouse recombining segment
            share DNA sequence homology
  JOURNAL   Nucleic Acids Res 15 (6), 2699-2705 (1987)
   PUBMED   3104881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084054.12.
            
            On Dec 22, 2017 this sequence version replaced XP_017176232.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region, initiates translation at an
            alternate start codon, and lacks an alternate exon in the 3' end
            compared to variant 1, that causes a frameshift. The encoded
            isoform (5) has shorter and distinct N- and C-termini compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.1229.1,
                                           SRR7345562.901085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.37 cM"
     Protein         1..383
                     /product="recombining binding protein suppressor of
                     hairless isoform 5"
                     /note="recombining binding protein suppressor of hairless;
                     J-kappa recombination signal binding protein; Jkappa
                     recombination signal binding protein"
                     /calculated_mol_wt=43087
     Region          35..165
                     /region_name="LAG1-DNAbind"
                     /note="LAG1, DNA binding; pfam09271"
                     /db_xref="CDD:462735"
     Region          193..315
                     /region_name="BTD"
                     /note="Beta-trefoil DNA-binding domain; pfam09270"
                     /db_xref="CDD:462734"
     CDS             1..383
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /coded_by="NM_001359152.1:220..1371"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
ORIGIN      
        1 mapvvtgkfg erpppkrltr eamrnylker gdqtvlilha kvaqksygne krffcpppcv
       61 ylmgsgwkkk keqmerdgcs eqesqpcafi gignsdqemq qlnlegknyc taktlyisds
      121 dkrkhfmlsv kmfygnsddi gvflskrikv iskpskkkqs lknadlcias gtkvalfnrl
      181 rsqtvstryl hveggnfhas sqqwgafyih lldddesege eftvrdgyih ygqtvklvcs
      241 vtgmalprli irkvdkqtal ldaddpvsql hkcafylkdt ermylclsqe riiqfqatpc
      301 pkeqnkemin dgaswtiist dkaeytfyeg mgpvlapvtp vpvveslqmw rehalcgprh
      361 fcipgrlemg ppaspgssdf gpk
//
LOCUS       NP_034260                931 aa            linear   ROD 27-AUG-2025
DEFINITION  adhesion G protein-coupled receptor E1 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_034260
VERSION     NP_034260.1
DBSOURCE    REFSEQ: accession NM_010130.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 931)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 931)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 931)
  AUTHORS   Kashimada,A., Mizuno,T., Tanaka,E., Hosokawa,S., Udagawa,T.,
            Hiraoka,Y., Uchida,K., Morio,T., Kosaki,K. and Takagi,M.
  TITLE     De novo variant in RING finger protein 213 causes systemic
            vasculopathy
  JOURNAL   JCI Insight 10 (11), e190094 (2025)
   PUBMED   40485582
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 931)
  AUTHORS   Weinhaus,B., Homan,S., Kincaid,M., Tadwalkar,A., Gu,X., Kumar,S.,
            Slaughter,A., Zhang,J., Wu,Q., Kofron,J.M., Troutman,T.D.,
            DeFalco,T. and Lucas,D.
  TITLE     Differential regulation of fetal bone marrow and liver
            hematopoiesis by yolk-sac-derived myeloid cells
  JOURNAL   Nat Commun 16 (1), 4427 (2025)
   PUBMED   40368906
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 931)
  AUTHORS   Hu,B., Liu,X., Xiong,S., Gong,Q., Yang,J., Shi,H., Zhang,M.,
            Liang,F. and Zhang,Z.
  TITLE     Increased cardiac macrophages in Sorbs2-deficient hearts: revealing
            a potential role for macrophage in responding to embryonic
            myocardial abnormalities
  JOURNAL   Front Genet 15, 1525931 (2025)
   PUBMED   39882075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 931)
  AUTHORS   McKnight,A.J. and Gordon,S.
  TITLE     EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte
            cell-surface molecules
  JOURNAL   Immunol Today 17 (6), 283-287 (1996)
   PUBMED   8962632
  REMARK    Review article
REFERENCE   7  (residues 1 to 931)
  AUTHORS   Luciani,M.F. and Chimini,G.
  TITLE     The ATP binding cassette transporter ABC1, is required for the
            engulfment of corpses generated by apoptotic cell death
  JOURNAL   EMBO J 15 (2), 226-235 (1996)
   PUBMED   8617198
REFERENCE   8  (residues 1 to 931)
  AUTHORS   McKnight,A.J., Macfarlane,A.J., Dri,P., Turley,L., Willis,A.C. and
            Gordon,S.
  TITLE     Molecular cloning of F4/80, a murine macrophage-restricted cell
            surface glycoprotein with homology to the G-protein-linked
            transmembrane 7 hormone receptor family
  JOURNAL   J Biol Chem 271 (1), 486-489 (1996)
   PUBMED   8550607
REFERENCE   9  (residues 1 to 931)
  AUTHORS   Timsit,S., Martinez,S., Allinquant,B., Peyron,F., Puelles,L. and
            Zalc,B.
  TITLE     Oligodendrocytes originate in a restricted zone of the embryonic
            ventral neural tube defined by DM-20 mRNA expression
  JOURNAL   J Neurosci 15 (2), 1012-1024 (1995)
   PUBMED   7869079
REFERENCE   10 (residues 1 to 931)
  AUTHORS   Chen,H.L., Kamath,R., Pace,J.L., Russell,S.W. and Hunt,J.S.
  TITLE     Gestation-related expression of the interferon-gamma receptor gene
            in mouse uterine and embryonic hematopoietic cells
  JOURNAL   J Leukoc Biol 55 (5), 617-625 (1994)
   PUBMED   8182339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010434.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66888.1, X93328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.8 cM"
     Protein         1..931
                     /product="adhesion G protein-coupled receptor E1 isoform 1
                     precursor"
                     /note="EGF-like module-containing mucin-like hormone
                     receptor-like 1; cell surface glycoprotein F4/80; EMR1
                     hormone receptor; EGF-like module receptor 1; EGF-like
                     module containing, mucin-like, hormone receptor-like
                     sequence 1"
                     /calculated_mol_wt=98893
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
                     /calculated_mol_wt=3256
     mat_peptide     28..931
                     /product="Adhesion G protein-coupled receptor E1.
                     /id=PRO_0000012874"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
                     /calculated_mol_wt=98893
     Region          33..63
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          81..115
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(81,84,100)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          133..172
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(133,136,151)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            148
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          173..>203
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(173,176,191)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          222..258
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(222,225,241)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            229
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            269
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          272..>301
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(272,275,288)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            283
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          319..352
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(319,322,338)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            405
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            417
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            474
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            498
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          506..508
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          591..640
                     /region_name="GPS"
                     /note="G-protein-coupled receptor proteolytic site domain;
                     smart00303"
                     /db_xref="CDD:197639"
     Region          595..642
                     /region_name="GPS.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00098"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          644..906
                     /region_name="7tmB2_EMR"
                     /note="epidermal growth factor-like module-containing
                     mucin-like hormone receptors, member of the class B2
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15439"
                     /db_xref="CDD:320555"
     Site            645..672
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          646..671
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320555"
     Site            order(651,655,697,700..701,704,711,718,795..796,798,800,
                     856,859,871,875)
                     /site_type="other"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]"
                     /db_xref="CDD:320555"
     Region          680..702
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320555"
     Site            680..701
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Site            706
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          711..738
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320555"
     Site            712..735
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Site            755..776
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          755..775
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320555"
     Region          792..815
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320555"
     Site            793..821
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          839..864
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320555"
     Site            840..859
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          868..893
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320555"
     Site            875..897
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     CDS             1..931
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /coded_by="NM_010130.5:27..2822"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS50160.1"
                     /db_xref="GeneID:13733"
                     /db_xref="MGI:MGI:106912"
ORIGIN      
        1 mwgfwlllfw gfsgmyrwgm ttlptlgqtl ggvnecqdtt tcpayatctd ttdsyyctck
       61 rgflssngqt nfqgpgvecq dvneclqsds pcgpnsvctn ilgrakcscl rgfssstgkd
      121 wilgsldnfl cadvdeclti gicpkysncs nsvgsysctc qpgfvlngsi cededecvtr
      181 dvcpehatch ntlgsyyctc nsglessggg pmfqgldesc edvdecsrns tlcgptfici
      241 ntlgsyscsc pagfslptfq ilghpadgnc tdidecddtc plnssctnti gsyfctchpg
      301 fassngqlnf kdlevtcedi dectqdplqc glnsvctnvp gsyicgclpd fqmdpegsqg
      361 ygnfnckril fkckedlilq seqiqqcqav qgrdlgyasf ctlvnatfti ldntcenksa
      421 pvslqsaats vslvleqatt wfelskeets tlgtilletv estmlaalli psgnasqmiq
      481 teyldieskv ineeckenes inlaargdkm nvgcfiikes vstgapgvaf vsfahmesvl
      541 nerffedgqs frklrmnsrv vggtvtgekk edfskpiiyt lqhiqpkqks erpicvswnt
      601 dvedgrwtps gceiveaset htvcscnrma nlaiimasge ltmefslyii shvgtvislv
      661 clalaiatfl lcravqnhnt ymhlhlcvcl flakilfltg idktdnqtac aiiagflhyl
      721 flacffwmlv eavmlflmvr nlkvvnyfss rnikmlhlca fgyglpvlvv iisasvqprg
      781 ygmhnrcwln tetgfiwsfl gpvcmiitin svllawtlwv lrqklcsvss evsklkdtrl
      841 ltfkaiaqif ilgcswvlgi fqigplasim aylftiinsl qgafiflihc llnrqvrdey
      901 kklltrktdl sshsqtsgil lssmpstskm g
//
LOCUS       NP_796103               1040 aa            linear   ROD 27-AUG-2025
DEFINITION  contactin-2 precursor [Mus musculus].
ACCESSION   NP_796103 XP_358332
VERSION     NP_796103.2
DBSOURCE    REFSEQ: accession NM_177129.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1040)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   2  (residues 1 to 1040)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1040)
  AUTHORS   Dolique,T., Baudet,S., Charron,F. and Ferent,J.
  TITLE     A central role for Numb/Nbl in multiple Shh-mediated axon repulsion
            processes
  JOURNAL   iScience 28 (5), 112293 (2025)
   PUBMED   40276749
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1040)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1040)
  AUTHORS   Shi,J., Chen,Q., Lai,J., Zhu,J., Zhang,R., Mazid,M.A., Li,D., Su,H.
            and Qin,D.
  TITLE     Impact of c-JUN deficiency on thalamus development in mice and
            human neural models
  JOURNAL   Cell Biosci 14 (1), 149 (2024)
   PUBMED   39707500
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1040)
  AUTHORS   Serafini,T., Colamarino,S.A., Leonardo,E.D., Wang,H.,
            Beddington,R., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Netrin-1 is required for commissural axon guidance in the
            developing vertebrate nervous system
  JOURNAL   Cell 87 (6), 1001-1014 (1996)
   PUBMED   8978605
REFERENCE   7  (residues 1 to 1040)
  AUTHORS   Orioli,D., Henkemeyer,M., Lemke,G., Klein,R. and Pawson,T.
  TITLE     Sek4 and Nuk receptors cooperate in guidance of commissural axons
            and in palate formation
  JOURNAL   EMBO J 15 (22), 6035-6049 (1996)
   PUBMED   8947026
REFERENCE   8  (residues 1 to 1040)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 1040)
  AUTHORS   Whitesides,J.G. 3rd and LaMantia,A.S.
  TITLE     Distinct adhesive behaviors of neurons and neural precursor cells
            during regional differentiation in the mammalian forebrain
  JOURNAL   Dev Biol 169 (1), 229-241 (1995)
   PUBMED   7750641
REFERENCE   10 (residues 1 to 1040)
  AUTHORS   Wolfer,D.P., Henehan-Beatty,A., Stoeckli,E.T., Sonderegger,P. and
            Lipp,H.P.
  TITLE     Distribution of TAG-1/axonin-1 in fibre tracts and migratory
            streams of the developing mouse nervous system
  JOURNAL   J Comp Neurol 345 (1), 1-32 (1994)
   PUBMED   8089271
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ108593.1, BC066106.1,
            BC079585.1 and AK083808.1.
            
            On or before Oct 25, 2004 this sequence version replaced
            XP_358332.2, NP_796103.1.
            
            Summary: This gene encodes a member of the contactin family of
            proteins, part of the immunoglobulin superfamily of cell adhesion
            molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored
            neuronal membrane protein plays a role in the proliferation,
            migration, and axon guidance of neurons of the developing
            cerebellum. Mice lacking a functional copy of this gene exhibit
            epileptic seizures and elevated expression of A1 adenosine
            receptors. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147602.1, BC066106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1040
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.42 cM"
     Protein         1..1040
                     /product="contactin-2 precursor"
                     /note="axonin; TAX-1; axonin-1; axonal glycoprotein TAG-1;
                     transient axonal glycoprotein 1"
                     /calculated_mol_wt=110090
     sig_peptide     1..30
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
                     /calculated_mol_wt=3146
     mat_peptide     31..1014
                     /product="Contactin-2. /id=PRO_0000014697"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61330.2)"
                     /calculated_mol_wt=107354
     Region          37..133
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          59..63
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409437"
     Region          72..76
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409437"
     Site            78
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          95..99
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409437"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409437"
     Region          124..127
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409437"
     Region          141..230
                     /region_name="Ig2_Contactin-2-like"
                     /note="Second Ig domain of the neural cell adhesion
                     molecule contactin-2, and similar domains; cd05727"
                     /db_xref="CDD:409392"
     Region          143..148
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409392"
     Region          152..158
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Site            order(153,183,186,188)
                     /site_type="other"
                     /note="domain-domain interface [polypeptide binding]"
                     /db_xref="CDD:409392"
     Region          166..172
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          177..179
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409392"
     Region          184..189
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409392"
     Region          192..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          206..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Site            206
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          218..230
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          241..326
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          259..263
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          272..276
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          291..295
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          305..310
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          318..321
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          330..414
                     /region_name="Ig4_Contactin-2-like"
                     /note="Fourth Ig domain of the neural cell adhesion
                     molecule contactin-2, and similar domains; cd05728"
                     /db_xref="CDD:143205"
     Region          330..333
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:143205"
     Region          337..341
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:143205"
     Region          345..353
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          359..364
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(363,394,396,411)
                     /site_type="other"
                     /note="domain-domain interface [polypeptide binding]"
                     /db_xref="CDD:143205"
     Region          366..369
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:143205"
     Region          374..378
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:143205"
     Region          380..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          394..401
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          405..414
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Region          419..507
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          419..424
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          427..432
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          436..443
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          451..455
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Site            463
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          469..472
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          473..478
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Site            479
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          486..494
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          500..507
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Site            500
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          509..605
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            527
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          528..532
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409440"
     Region          543..547
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409440"
     Region          572..576
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409440"
     Region          586..591
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409440"
     Region          599..602
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409440"
     Region          620..707
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(695..696,698..699)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          728..808
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            777
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          796..798
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61330.2)"
     Site            order(798..799,801..802)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          817..909
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            832
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Region          897..922
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61330.2)"
     Site            order(898..899,901..902)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            920
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     Site            942
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61330.2)"
     CDS             1..1040
                     /gene="Cntn2"
                     /gene_synonym="D130012K04Rik; TAG-1; TAG1; Tax"
                     /coded_by="NM_177129.5:304..3426"
                     /db_xref="CCDS:CCDS15288.1"
                     /db_xref="GeneID:21367"
                     /db_xref="MGI:MGI:104518"
ORIGIN      
        1 mgaparkras llllllatma lvsspgwsfs qgtpatfgpv feeqpvgllf peesaedqvt
       61 lacraraspp atyrwkmngt emnlepgsrh qlmggnlvim sptkaqdagv yqclasnpvg
      121 tvvskeavlr fgflqefske erdpvktheg wgvmlpcnpp ahypglsyrw llnefpnfip
      181 tdgrhfvsqt tgnlyiartn asdlgnyscl atshldfstk svfskfaqln laaedprlfa
      241 psikarfppe tyalvgqqvt lecfafgnpv prikwrkvdg slspqwgtae ptlqipsvsf
      301 edegtyecea enskgrdtvq griivqaqpe wlkvisdtea digsnlrwgc aaagkprpmv
      361 rwlrngepla sqnrvevlag dlrfsklnle dsgmyqcvae nkhgtiyasa elavqalapd
      421 frqnpvrrli paarggeisi pcqpraapka tilwskgtei lgnstrvtvt ldgtliirni
      481 srsdegkytc faenfmgkan stgilsvrda tkitlapssa dinvgdnltl qchashdptm
      541 dltftwtldd fpvdfdkpgg hyrrasvket igdltilnaq lrhggtytcm aqtvvdgask
      601 eatvlvrgpp gppggvvvrd igdttvqlsw srgfdnhspi akytlqartp psgkwkqvrt
      661 npvniegnae taqvlglmpw mdyefrvsas nilgtgepsg pssrirtkea vpsvapsgls
      721 ggggapgelt inwtpmsrey qngdgfgyll sfrrqgsssw qtarvpgadt qyfvysndsi
      781 hpytpfevki rsynrrgdgp esltaivysa eeepkvapak vwakgsssse mnvswepvlq
      841 dmngillgye irywkagdke aaadrvrtag ldssarvtgl ypntkyhvtv raynragtgp
      901 aspsadamtm kppprrppgn iswtfssssl slkwdpvvpl rnestvtgyk mlyqndlqpt
      961 pmlhltsknw ieipvpedig halvqirttg pggdgipaev hivrnggtsm mvessavrpa
     1021 hpgpvfscmv ilmlagcqrl
//
LOCUS       NP_001411817             416 aa            linear   ROD 27-AUG-2025
DEFINITION  TGF-beta receptor type-1 isoform 6 [Mus musculus].
ACCESSION   NP_001411817
VERSION     NP_001411817.1
DBSOURCE    REFSEQ: accession NM_001424888.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Ware,K., Peter,J., McClain,L. and Luo,Y.
  TITLE     Cell type-dependent role of transforming growth factor-beta
            signaling on postnatal neural stem cell proliferation and migration
  JOURNAL   Neural Regen Res 21 (3), 1151-1161 (2026)
   PUBMED   39885664
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Tang,Q., Li,L., Li,Y., Wang,A., Li,H., Wang,L., Gu,C., Lee,J.M.,
            Wu,Z., Kwon,H.E. and Chen,Y.
  TITLE     Distinct BMP-Smad signaling outputs confer diverse functions in
            dental mesenchyme
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40446216
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Sugimoto,A., Saito,Y., Wang,G., Sun,Q., Yin,C., Lee,K.H., Geng,Y.,
            Rajbhandari,P., Hernandez,C., Steffani,M., Qie,J., Savage,T.,
            Goyal,D.M., Ray,K.C., Neelakantan,T.V., Yin,D., Melms,J.,
            Lehrich,B.M., Yasaka,T.M., Liu,S., Oertel,M., Lan,T., Guillot,A.,
            Peiseler,M., Filliol,A., Kanzaki,H., Fujiwara,N., Ravi,S., Izar,B.,
            Brosch,M., Hampe,J., Remotti,H., Argemi,J., Sun,Z., Kendall,T.J.,
            Hoshida,Y., Tacke,F., Fallowfield,J.A., Blockley-Powell,S.K.,
            Haeusler,R.A., Steinman,J.B., Pajvani,U.B., Monga,S.P.,
            Bataller,R., Masoodi,M., Arpaia,N., Lee,Y.A., Stockwell,B.R.,
            Augustin,H.G. and Schwabe,R.F.
  TITLE     Hepatic stellate cells control liver zonation, size and functions
            via R-spondin 3
  JOURNAL   Nature 640 (8059), 752-761 (2025)
   PUBMED   40074890
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Wang,X., Zhao,X., Zheng,X., Peng,X., Chen,J., Wang,Y., Wang,Z.,
            Meng,M. and Du,J.
  TITLE     Sirt6 loss activates Got1 and facilitates cleft palate through
            abnormal activating glycolysis
  JOURNAL   Cell Death Dis 16 (1), 159 (2025)
   PUBMED   40050262
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Lozovska,A., Casaca,A., Novoa,A., Kuo,Y.Y., Jurberg,A.D.,
            Martins,G.G., Hadjantonakis,A.K. and Mallo,M.
  TITLE     Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization
            during the trunk to tail transition
  JOURNAL   Elife 13, 94290 (2025)
   PUBMED   39874182
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H.,
            Ohtani,H., Hayashi,Y. and Eto,K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (residues 1 to 416)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772150.11.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.148844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     Protein         1..416
                     /product="TGF-beta receptor type-1 isoform 6"
                     /EC_number="2.7.11.30"
                     /note="TGF-beta receptor type-1; TGF-beta receptor type I;
                     transforming growth factor-beta receptor type I"
                     /calculated_mol_wt=47056
     Region          89..116
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:462503"
     Region          122..409
                     /region_name="STKc_TGFbR1_ACVR1b_ACVR1c"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Transforming Growth Factor beta Type I Receptor and
                     Activin Type IB/IC Receptors; cd14143"
                     /db_xref="CDD:271045"
     Site            order(124..128,132,143,145,173,193..196,200,202,246,248,
                     250..251,253,264,267,287..290)
                     /site_type="active"
                     /db_xref="CDD:271045"
     Site            order(124..130,132,143,145,193..194,196,200,250..251,253,
                     264)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271045"
     Site            order(128,200,202,246,248,250,267,287..290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271045"
     Site            order(155..156,159..160,163..164,178,180)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271045"
     Site            263..290
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271045"
     CDS             1..416
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /coded_by="NM_001424888.1:174..1424"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
ORIGIN      
        1 mdlkslimvm medykditpl kklqenkekq saglgpvela aviagpvcfv cialmlmvyi
       61 chnrtvihhr vpneedpsld rpfisegttl kdliydmtts gsgsglpllv qrtiartivl
      121 qesigkgrfg evwrgkwrge evavkifssr eerswfreae iyqtvmlrhe nilgfiaadn
      181 kdngtwtqlw lvsdyhehgs lfdylnrytv tvegmiklal stasglahlh meivgtqgkp
      241 aiahrdlksk nilvkkngtc ciadlglavr hdsatdtidi apnhrvgtkr ymapevldds
      301 inmkhfesfk radiyamglv fweiarrcsi ggihedyqlp yydlvpsdps veemrkvvce
      361 qklrpnipnr wqscealrvm akimrecwya ngaarltalr ikktlsqlsq qegikm
//
LOCUS       NP_001351287             160 aa            linear   ROD 27-AUG-2025
DEFINITION  microtubule-associated protein 1 light chain 3 beta isoform 2 [Mus
            musculus].
ACCESSION   NP_001351287
VERSION     NP_001351287.1
DBSOURCE    REFSEQ: accession NM_001364358.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 160)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 160)
  AUTHORS   Qi,W., Cai,Y. and Wang,X.
  TITLE     Hydroxychloroquine confers placental protection in antiphospholipid
            Syndrome: Mechanistic insights into autophagy regulation and
            trophoblast dysfunction
  JOURNAL   Biochem Biophys Res Commun 770, 151994 (2025)
   PUBMED   40393103
REFERENCE   3  (residues 1 to 160)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   4  (residues 1 to 160)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 160)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   6  (residues 1 to 160)
  AUTHORS   Tanida,I., Ueno,T. and Kominami,E.
  TITLE     LC3 conjugation system in mammalian autophagy
  JOURNAL   Int J Biochem Cell Biol 36 (12), 2503-2518 (2004)
   PUBMED   15325588
  REMARK    Review article
REFERENCE   7  (residues 1 to 160)
  AUTHORS   Nemoto,T., Tanida,I., Tanida-Miyake,E., Minematsu-Ikeguchi,N.,
            Yokota,M., Ohsumi,M., Ueno,T. and Kominami,E.
  TITLE     The mouse APG10 homologue, an E2-like enzyme for Apg12p
            conjugation, facilitates MAP-LC3 modification
  JOURNAL   J Biol Chem 278 (41), 39517-39526 (2003)
   PUBMED   12890687
REFERENCE   8  (residues 1 to 160)
  AUTHORS   Gonzalez-Billault,C., Owen,R., Gordon-Weeks,P.R. and Avila,J.
  TITLE     Microtubule-associated protein 1B is involved in the initial stages
            of axonogenesis in peripheral nervous system cultured neurons
  JOURNAL   Brain Res 943 (1), 56-67 (2002)
   PUBMED   12088839
  REMARK    GeneRIF: MAP1B is involved in the initial stages of axonogenesis,
            as shown by reduced axon length and increased growth cone size of
            cultured dorsal root ganglion neurons from MAP1B deficient mice.
REFERENCE   9  (residues 1 to 160)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   10 (residues 1 to 160)
  AUTHORS   Gonzalez-Billault,C., Demandt,E., Wandosell,F., Torres,M.,
            Bonaldo,P., Stoykova,A., Chowdhury,K., Gruss,P., Avila,J. and
            Sanchez,M.P.
  TITLE     Perinatal lethality of microtubule-associated protein 1B-deficient
            mice expressing alternative isoforms of the protein at low levels
  JOURNAL   Mol Cell Neurosci 16 (4), 408-421 (2000)
   PUBMED   11085878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC182458.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.940526.1,
                                           SRR5189670.144111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.67 cM"
     Protein         1..160
                     /product="microtubule-associated protein 1 light chain 3
                     beta isoform 2"
                     /note="microtubule-associated proteins 1A/1B light chain
                     3B; MAP1A/MAP1B light chain 3 B; autophagy-related protein
                     LC3 B; MAP1 light chain 3-like protein 2;
                     autophagy-related ubiquitin-like modifier LC3 B"
                     /calculated_mol_wt=18045
     Region          5..154
                     /region_name="Ubl_ATG8_MAP1LC3B"
                     /note="ubiquitin-like (Ubl) domain found in microtubule
                     associate protein 1 light chain 3B (MAP1LC3B); cd17235"
                     /db_xref="CDD:340755"
     Site            order(5,10..11,19..20,23,26,30,32,84,86..90,92..93,98,101,
                     104..105,143)
                     /site_type="other"
                     /note="peptide binding site 2 [polypeptide binding]"
                     /db_xref="CDD:340755"
     Site            order(19..20,22..23,26..27,30,32,68,70,84,86..90,93,
                     97..98,100..102,104..105,143)
                     /site_type="other"
                     /note="peptide binding site 1 [polypeptide binding]"
                     /db_xref="CDD:340755"
     Site            order(23,28..30,86..88,90..92,97,101,105,143)
                     /site_type="other"
                     /note="Atg13 interaction site [polypeptide binding]"
                     /db_xref="CDD:340755"
     Site            order(30,71..72,84,87,96..97,99..101,103..105,111,
                     113..115,117,120..121,125..127,152..154)
                     /site_type="other"
                     /note="Atg7 interaction site [polypeptide binding]"
                     /db_xref="CDD:340755"
     Site            order(73,99,103,110..115,117,120..121,124..126,147,
                     149..154)
                     /site_type="other"
                     /note="Atg4 interaction site [polypeptide binding]"
                     /db_xref="CDD:340755"
     CDS             1..160
                     /gene="Map1lc3b"
                     /gene_synonym="1010001C15Rik; Atg8; LC3b; MAP1A/MAP1B;
                     Map1lc3"
                     /coded_by="NM_001364358.1:88..570"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS90470.1"
                     /db_xref="GeneID:67443"
                     /db_xref="MGI:MGI:1914693"
ORIGIN      
        1 mpsektfkqr rsfeqrvedv rlireqhptk ipvgspaarg dpnpigaprs pgkpqapdls
       61 rgkrgrrvii erykgekqlp vldktkflvp dhvnmselik iirrrlqlna nqaffllvng
      121 hsmvsvstpi sevyeserde dgflymvyas qetfgtamav
//
LOCUS       NP_076113                231 aa            linear   ROD 27-AUG-2025
DEFINITION  lecithin retinol acyltransferase [Mus musculus].
ACCESSION   NP_076113
VERSION     NP_076113.1
DBSOURCE    REFSEQ: accession NM_023624.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 231)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 231)
  AUTHORS   Shymotiuk,I., Froese,N., Werlein,C., Naasner,L., Szaroszyk,M.,
            Kuhnel,M.P., Jonigk,D.D., Blaner,W.S., Wende,A.R., Abel,E.D.,
            Bauersachs,J. and Riehle,C.
  TITLE     Vitamin A regulates tissue-specific organ remodeling in
            diet-induced obesity independent of mitochondrial function
  JOURNAL   Front Endocrinol (Lausanne) 14, 1118751 (2023)
   PUBMED   36891060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 231)
  AUTHORS   Huh,C.Y.L., Leinonen,H., Nakayama,T., Tomasello,J.R., Zhang,J.,
            Zeitoun,J., Peach,J.P., Halabi,M., Kiser,J.Z., Palczewski,K.,
            Kiser,P.D. and Gandhi,S.P.
  TITLE     Retinoid therapy restores eye-specific cortical responses in adult
            mice with retinal degeneration
  JOURNAL   Curr Biol 32 (20), 4538-4546 (2022)
   PUBMED   36152631
REFERENCE   4  (residues 1 to 231)
  AUTHORS   Chen,Q.T., Zhang,Z.Y., Huang,Q.L., Chen,H.Z., Hong,W.B., Lin,T.,
            Zhao,W.X., Wang,X.M., Ju,C.Y., Wu,L.Z., Huang,Y.Y., Hou,P.P.,
            Wang,W.J., Zhou,D., Deng,X. and Wu,Q.
  TITLE     HK1 from hepatic stellate cell-derived extracellular vesicles
            promotes progression of hepatocellular carcinoma
  JOURNAL   Nat Metab 4 (10), 1306-1321 (2022)
   PUBMED   36192599
REFERENCE   5  (residues 1 to 231)
  AUTHORS   Yan,F.Z., Qian,H., Liu,F., Ding,C.H., Liu,S.Q., Xiao,M.C.,
            Chen,S.J., Zhang,X., Luo,C. and Xie,W.F.
  TITLE     Inhibition of protein arginine methyltransferase 1 alleviates liver
            fibrosis by attenuating the activation of hepatic stellate cells in
            mice
  JOURNAL   FASEB J 36 (9), e22489 (2022)
   PUBMED   35959865
REFERENCE   6  (residues 1 to 231)
  AUTHORS   Liu,L. and Gudas,L.J.
  TITLE     Disruption of the lecithin:retinol acyltransferase gene makes mice
            more susceptible to vitamin A deficiency
  JOURNAL   J Biol Chem 280 (48), 40226-40234 (2005)
   PUBMED   16174770
  REMARK    GeneRIF: LRAT-/- mice are much more susceptible to vitamin A
            deficiency and should be an excellent animal model of vitamin A
            deficiency
REFERENCE   7  (residues 1 to 231)
  AUTHORS   O'Byrne,S.M., Wongsiriroj,N., Libien,J., Vogel,S., Goldberg,I.J.,
            Baehr,W., Palczewski,K. and Blaner,W.S.
  TITLE     Retinoid absorption and storage is impaired in mice lacking
            lecithin:retinol acyltransferase (LRAT)
  JOURNAL   J Biol Chem 280 (42), 35647-35657 (2005)
   PUBMED   16115871
  REMARK    GeneRIF: LRAT has a role in retinoid absorption and storage
REFERENCE   8  (residues 1 to 231)
  AUTHORS   Batten,M.L., Imanishi,Y., Maeda,T., Tu,D.C., Moise,A.R.,
            Bronson,D., Possin,D., Van Gelder,R.N., Baehr,W. and Palczewski,K.
  TITLE     Lecithin-retinol acyltransferase is essential for accumulation of
            all-trans-retinyl esters in the eye and in the liver
  JOURNAL   J Biol Chem 279 (11), 10422-10432 (2004)
   PUBMED   14684738
  REMARK    GeneRIF: Lecithin-retinol acyltransferase is essential for
            accumulation of all-trans-retinyl esters in the eye and in the
            liver
REFERENCE   9  (residues 1 to 231)
  AUTHORS   Zolfaghari,R. and Ross,A.C.
  TITLE     Lecithin:retinol acyltransferase from mouse and rat liver. CDNA
            cloning and liver-specific regulation by dietary vitamin a and
            retinoic acid
  JOURNAL   J Lipid Res 41 (12), 2024-2034 (2000)
   PUBMED   11108736
REFERENCE   10 (residues 1 to 231)
  AUTHORS   Ghyselinck,N.B., Bavik,C., Sapin,V., Mark,M., Bonnier,D.,
            Hindelang,C., Dierich,A., Nilsson,C.B., Hakansson,H., Sauvant,P.,
            Azais-Braesco,V., Frasson,M., Picaud,S. and Chambon,P.
  TITLE     Cellular retinol-binding protein I is essential for vitamin A
            homeostasis
  JOURNAL   EMBO J 18 (18), 4903-4914 (1999)
   PUBMED   10487743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158935.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255061.2, BC141375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.81 cM"
     Protein         1..231
                     /product="lecithin retinol acyltransferase"
                     /EC_number="2.3.1.135"
                     /note="phosphatidylcholine--retinol O-acyltransferase"
                     /calculated_mol_wt=25689
     Region          56..171
                     /region_name="LRAT"
                     /note="Lecithin retinol acyltransferase; pfam04970"
                     /db_xref="CDD:398571"
     Site            195..215
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JI60.1)"
     CDS             1..231
                     /gene="Lrat"
                     /gene_synonym="1300010A18Rik"
                     /coded_by="NM_023624.4:263..958"
                     /db_xref="CCDS:CCDS17430.1"
                     /db_xref="GeneID:79235"
                     /db_xref="MGI:MGI:1891259"
ORIGIN      
        1 mknpmleaas llleklllis nfklfsvsvp gggtgknrpy eissfvrgdv levsrthfih
       61 ygiylgenrv ahlmpdilla ltndkertqk vvsnkrlllg vickvasirv dtvedfayga
      121 dilvnhldgt lkkksllnee varraeqqlg ltpysllwnn cehfvtycry gsrispqaek
      181 fydtvkiiir dqrsslasav lglasivytg lasymtlpai cipfclwmms g
//
LOCUS       NP_001419109             475 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor EB [Mus musculus].
ACCESSION   NP_001419109
VERSION     NP_001419109.1
DBSOURCE    REFSEQ: accession NM_001432180.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Custode,B.M., Annunziata,F., Dos Santos Matos,F., Schiano,V.,
            Maffia,V., Lillo,M., Colonna,R., De Cegli,R., Ballabio,A. and
            Pastore,N.
  TITLE     Folliculin depletion results in liver cell damage and
            cholangiocarcinoma through MiT/TFE activation
  JOURNAL   Cell Death Differ 32 (8), 1460-1472 (2025)
   PUBMED   40189703
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Kumar,G.V.N., Wang,R.S., Sharma,A.X., David,N.L., Amorim,T.,
            Sinden,D.S., Doshi,N.K., Wabitsch,M., Gingras,S., Ejaz,A.,
            Rubin,J.P., Maron,B.A., Fazeli,P.K. and Steinhauser,M.L.
  TITLE     Non-canonical lysosomal lipolysis drives mobilization of adipose
            tissue energy stores with fasting
  JOURNAL   Nat Commun 16 (1), 1330 (2025)
   PUBMED   39900947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Lei,Q., Chen,X., Xiong,Y., Li,S., Wang,J., He,H. and Deng,Y.
  TITLE     Lysosomal Ca2+ release-facilitated TFEB nuclear translocation
            alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons
  JOURNAL   Sci Rep 14 (1), 24836 (2024)
   PUBMED   39438678
  REMARK    GeneRIF: Lysosomal Ca[2+] release-facilitated TFEB nuclear
            translocation alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124830.8 and AC113536.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.9884288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..475
                     /product="transcription factor EB"
                     /calculated_mol_wt=52483
     Region          1..166
                     /region_name="Interaction with ACSS2.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          4..161
                     /region_name="MITF_TFEB_C_3_N"
                     /note="MITF/TFEB/TFEC/TFE3 N-terminus; pfam15951"
                     /db_xref="CDD:464952"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          135..152
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          155..164
                     /region_name="Strong transcription activation domain.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          225..315
                     /region_name="bHLHzip_TFEB"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in transcription factor EB (TFEB) and similar
                     proteins; cd18927"
                     /db_xref="CDD:381497"
     Site            order(239..240,242..243,246..247,251,272..273)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381497"
     Region          244..247
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            order(249..250,253..254,256,260,273,277..278,281,283..285,
                     287..288,290..291,294,297..299)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381497"
     Region          297..318
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          320..472
                     /region_name="DUF3371"
                     /note="Domain of unknown function (DUF3371); pfam11851"
                     /db_xref="CDD:463372"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          351..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          445..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     CDS             1..475
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /coded_by="NM_001432180.1:387..1814"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
ORIGIN      
        1 masriglrmq lmreqaqqee qrermqqqav mhymqqqqqq qqqlggpptp aintpvhfqs
       61 pppvpgevlk vqsylenpts yhlqqsqhqk vreylsetyg nkfaahvspa qgspkpapaa
      121 spgvraghvl stsagnsapn spmamlhiss npekefddvi dnimrldsvl gyinpemqmp
      181 ntlplssshl nvysgdpqvt asmvgvtsss cpadltqkre ltdaesrala kerqkkdnhn
      241 lierrrrfni ndrikelgml ipkandldvr wnkgtilkas vdyirrmqkd lqksrelenh
      301 srrlemtnkq lwlriqelem qarvhglptt spsgvnmael aqqvvkqelp sedgpgealm
      361 lgpevpepeq mpalppqapl psaaqpqspf hhldfshgls fggggdegpt gypdtlgteh
      421 gspfpnlskk dldlmlldds llplasdplf stmspeaska ssrrssfsme egdvl
//
LOCUS       NP_001395642             147 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7
            [Mus musculus].
ACCESSION   NP_001395642
VERSION     NP_001395642.1
DBSOURCE    REFSEQ: accession NM_001408713.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.2232906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..147
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 7"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=16779
     Region          49..143
                     /region_name="PWWP"
                     /note="PWWP (Pro-Trp-Trp-Pro) domain; cl02554"
                     /db_xref="CDD:470613"
     Site            order(65,68,99)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438958"
     Site            66..69
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438958"
     CDS             1..147
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408713.1:274..717"
                     /note="isoform 7 is encoded by transcript variant 17"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mppktrtals ddpdsspspl gnmleipgts spstsqelpf cqpkkkstpl kyevgdliwa
       61 kfkrrpwwpc ricsdplint hskmkvanrr pyreyyveaf gdpsekawva gkaivmfegr
      121 hqfeelpvlr krgkqkekgy rhkgfcv
//
LOCUS       NP_001415445            1426 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 2 isoform 1 [Mus musculus].
ACCESSION   NP_001415445
VERSION     NP_001415445.1
DBSOURCE    REFSEQ: accession NM_001428516.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1426)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1426)
  AUTHORS   Iulianella,A., Vanden Heuvel,G. and Trainor,P.
  TITLE     Dynamic expression of murine Cux2 in craniofacial, limb, urogenital
            and neuronal primordia
  JOURNAL   Gene Expr Patterns 3 (5), 571-577 (2003)
   PUBMED   12971989
REFERENCE   7  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Quaggin,S.E. and Igarashi,P.
  TITLE     A unique variant of a homeobox gene related to Drosophila cut is
            expressed in mouse testis
  JOURNAL   Biol Reprod 55 (4), 731-739 (1996)
   PUBMED   8879483
REFERENCE   8  (residues 1 to 1426)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Bodmer,R., McConnell,K.R., Nagami,G.T. and
            Igarashi,P.
  TITLE     Expression of a cut-related homeobox gene in developing and
            polycystic mouse kidney
  JOURNAL   Kidney Int 50 (2), 453-461 (1996)
   PUBMED   8840273
REFERENCE   10 (residues 1 to 1426)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140353.2 and AC113302.13.
            
            Summary: This gene is a member of the Cut family of transcription
            factors that have multiple DNA binding domains and regulate cell
            proliferation and differentiation. This gene is primarily expressed
            in nervous tissues where it controls the proliferation of neuronal
            precursors, and may play a role in organogenesis earlier during
            embryonic development. Mice lacking the encoded protein exhibit
            smaller spinal cords with deficits in neural progenitor development
            as well as in neuroblast and interneuron differentiation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.311067.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.02 cM"
     Protein         1..1426
                     /product="homeobox protein cut-like 2 isoform 1"
                     /note="homeobox protein cut-like 2; homeobox protein
                     Cux-2"
                     /calculated_mol_wt=154533
     Region          77..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14529; propagated from
                     UniProtKB/Swiss-Prot (P70298.2)"
     Region          <116..>316
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          351..419
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          460..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          487..563
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          599..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          653..676
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          743..769
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          833..906
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          904..977
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          988..1064
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1114..1170
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1177..1392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     CDS             1..1426
                     /gene="Cux2"
                     /gene_synonym="1700051K22Rik; Cutl2; Cux-2"
                     /coded_by="NM_001428516.1:215..4495"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="GeneID:13048"
                     /db_xref="MGI:MGI:107321"
ORIGIN      
        1 mvapvlksfq aevvalskrs reaeaaflsv ykqlieapdp vpsfevartl ddrlqrpsfd
       61 psgqrlqdvh iawkrcpepp sareqnegtc ptghtpangn hlpgpedtlv tdtllqknea
      121 erqkglqevh itlaarlgea eekikvlhsa lkatqtelle lrrkydeeaa skadevglim
      181 tnlekanqra eaaqrevesl reqlasvnss irlaccspqg psgekvsfal csgprleaal
      241 askdreilrl lkdaqqlrhs lqeleevsan qiadlerqla akseaieklq ekleaqadye
      301 eiktelsilr amklasstcs lpqtlakpdd pllvakdvff ptqkfllekp allaspeedp
      361 seddsikgsl gteppyppql ppppgpedpl spspaqpllg pslgpdgprt fslspfpsla
      421 pgerlagdsl lskhmmgpaa fkgetgnlla fpptfyggak ppsapaasvp cpeptgapea
      481 vdgagpeeeq ldtaeiafqv keqllkhnig qrvfghyvlg lsqgsvseil arpkpwrklt
      541 vkgkepfikm kqflsdeqnv lalrtiqvrq rgsitprirt petgsddaik sileqakkei
      601 esqkggeskn spasvsipng tassstseda iknileqarr emqaqqqall emesgprgrs
      661 vppspperps patasqngal tcvkqedggg gsgssstvqa plavlspaaf vqriirkvks
      721 eigdagyfdh hwasdrglls rpyasvspsl sssssysgqp ngrawprgde atiapedeaa
      781 mgedeaprvg elkaeagape vgggrlpyyp ayvprtlkpt vppltpeqye lymyrevdtl
      841 eltrqvkekl akngicqrif gekvlglsqg svsdmlsrpk pwskltqkgr epfirmqlwl
      901 sdqlgqgqgq aptqqpsasq aspteptssp spppsptepe ktsqeplgls lesskenqqp
      961 egrassslgg kpfsssqaag giqemvamsp eldtysitkr vkevltdnnl gqrlfgesil
     1021 gltqgsvsdl lsrpkpwhkl slkgrepfvr mqlwlsdphn veklrdmkkl ekkaylkrry
     1081 gligtgsdse spaahsecps pclqpqelsl mqakkprvvl apaekealrk ayqlepypsq
     1141 qtiellsfql nlktntvinw fhnyrsrmrr emlvegtqdd pdfdpsggpn vltpghthre
     1201 ptpqspdset edqkppmksl elqepegplq raapdralvk ikqeeglevd gdsqpqdvgd
     1261 pdrgqdgpke ehthplgnsd lselapgpfl sgtpnpdcps lhnpqekgtg eqvhseplsf
     1321 kstsessccs legppnspsv isspdlttcv spapsssapi spslpgappa kvpstsptgd
     1381 taaalhpstk vnpnlqrrhe kmanlnsiiy rleraanree vlewef
//
LOCUS       NP_033268                302 aa            linear   ROD 27-AUG-2025
DEFINITION  SPARC precursor [Mus musculus].
ACCESSION   NP_033268 XP_916834
VERSION     NP_033268.1
DBSOURCE    REFSEQ: accession NM_009242.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 302)
  AUTHORS   Cain,J.W., Erikson,D.W., Seo,H., Ross,A., Burghardt,R.C.,
            Bazer,F.W. and Johnson,G.A.
  TITLE     SPARC expression in the mouse decidua, placenta, and fetus:
            correlations with SPP1 expression
  JOURNAL   Placenta 168, 125-134 (2025)
   PUBMED   40544540
REFERENCE   2  (residues 1 to 302)
  AUTHORS   Li,C., Zhang,M., Du,Y., Liu,S., Li,D., Zhang,S., Ji,F., Zhang,J.
            and Jiao,J.
  TITLE     Compromised cell competition exhausts neural stem cells pool
  JOURNAL   Cell Prolif 57 (12), e13710 (2024)
   PUBMED   39010274
REFERENCE   3  (residues 1 to 302)
  AUTHORS   Xiao,G., Wei,Y., Xie,R., Tsang,Y., Gu,J., Shen,D., Ding,M.,
            Yuan,J., Xu,D. and Fei,J.
  TITLE     Citric acid promotes SPARC release in pancreatic cancer cells and
            inhibits the progression of pancreatic tumors in mice on a high-fat
            diet
  JOURNAL   FEBS J 291 (8), 1699-1718 (2024)
   PUBMED   38245817
  REMARK    GeneRIF: Citric acid promotes SPARC release in pancreatic cancer
            cells and inhibits the progression of pancreatic tumors in mice on
            a high-fat diet.
REFERENCE   4  (residues 1 to 302)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 302)
  AUTHORS   Arai,M., Kaku,M., Thant,L., Kitami,M., Ono,Y., Dobashi,A.,
            Iwama,H., Mizukoshi,M., Kitami,K., Matsumoto,M., Saito,I. and
            Uoshima,K.
  TITLE     Effect of Sparc knockout on the extracellular matrix of mouse
            periodontal ligament cells
  JOURNAL   Biochem Biophys Res Commun 692, 149364 (2024)
   PUBMED   38070276
  REMARK    GeneRIF: Effect of Sparc knockout on the extracellular matrix of
            mouse periodontal ligament cells.
REFERENCE   6  (residues 1 to 302)
  AUTHORS   Baron,B., Poirier,C., Simon-Chazottes,D., Barnier,C. and
            Guenet,J.L.
  TITLE     A new strategy useful for rapid identification of microsatellites
            from DNA libraries with large size inserts
  JOURNAL   Nucleic Acids Res 20 (14), 3665-3669 (1992)
   PUBMED   1386425
REFERENCE   7  (residues 1 to 302)
  AUTHORS   Bloom,M.L., Lee,B.K., Birkenmeier,C.S., Ma,Y., Zimmer,W.E.,
            Goodman,S.R., Eicher,E.M. and Barker,J.E.
  TITLE     Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 3 (5), 293-295 (1992)
   PUBMED   1638088
REFERENCE   8  (residues 1 to 302)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 302)
  AUTHORS   Baldacci,P.A., Richoux,V., Renard,J.P., Guenet,J.L. and Babinet,C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   10 (residues 1 to 302)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781653.1, BB857564.1, AK161229.1, AA798908.1, CJ132527.1 and
            BE655213.1.
            
            On Dec 7, 2005 this sequence version replaced XP_916834.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.15933.1,
                                           SRR1660811.202887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.04 cM"
     Protein         1..302
                     /product="SPARC precursor"
                     /note="basement-membrane protein 40; secreted protein
                     acidic and rich in cysteine; osteonectin"
                     /calculated_mol_wt=32516
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1952
     mat_peptide     18..302
                     /product="SPARC. /id=PRO_0000020305"
                     /note="propagated from UniProtKB/Swiss-Prot (P07214.1)"
                     /calculated_mol_wt=32516
     Region          70..151
                     /region_name="FSL_SPARC"
                     /note="Follistatin-like SPARC (secreted protein, acidic,
                     and rich in cysteines) domain; SPARC/BM-40/osteonectin is
                     a multifunctional glycoprotein which modulates cellular
                     interaction with the extracellular matrix by its binding
                     to structural matrix proteins...; cd01328"
                     /db_xref="CDD:238649"
     Site            115
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238649"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:3427055; propagated from
                     UniProtKB/Swiss-Prot (P07214.1)"
     Region          154..293
                     /region_name="EFh_SPARC_SPARC"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in secreted protein acidic and rich in cysteine
                     (SPARC); cd16235"
                     /db_xref="CDD:320014"
     Site            order(161..162,165..166,168..169,172..173,176,180,258,
                     261..262)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320014"
     Region          226..259
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     Site            order(238,243,250,273,275,277,284)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320014"
     Site            order(248..249,263)
                     /site_type="other"
                     /note="EC/FS-domain interface"
                     /db_xref="CDD:320014"
     Region          261..293
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     CDS             1..302
                     /gene="Sparc"
                     /gene_synonym="BM-40; ON"
                     /coded_by="NM_009242.5:307..1215"
                     /db_xref="CCDS:CCDS24712.1"
                     /db_xref="GeneID:20692"
                     /db_xref="MGI:MGI:98373"
ORIGIN      
        1 mrawiffllc lagralaapq qtevaeeive eetvveetgv pvganpvqve mgefedgaee
       61 tveevvadnp cqnhhckhgk vceldesntp mcvcqdptsc papigefekv csndnktfds
      121 schffatkct legtkkghkl hldyigpcky iapcldselt efplrmrdwl knvlvtlyer
      181 degnnlltek qklrvkkihe nekrleagdh pvellardfe knynmyifpv hwqfgqldqh
      241 pidgylshte laplraplip mehcttrffe tcdldndkyi aleewagcfg ikeqdinkdl
      301 vi
//
LOCUS       NP_035169                503 aa            linear   ROD 27-AUG-2025
DEFINITION  paired box protein Pax-7 [Mus musculus].
ACCESSION   NP_035169
VERSION     NP_035169.1
DBSOURCE    REFSEQ: accession NM_011039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Li,Y., Li,C., Zhou,Q., Liu,X., Qiao,Y., Xie,T., Sun,H., Ong,M.T.
            and Wang,H.
  TITLE     Multiomics and cellular senescence profiling of aging human
            skeletal muscle uncovers Maraviroc as a senotherapeutic approach
            for sarcopenia
  JOURNAL   Nat Commun 16 (1), 6207 (2025)
   PUBMED   40617829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Aoto,M., Sakai,H., Tokunaga,N., Miyazaki,M., Kiyoi,T., Ohkubo,N.,
            Imai,Y. and Mitsuda,N.
  TITLE     The splicing factor Acin1 is essential for embryonic development
            but has limited effects on muscle structure and homeostasis
  JOURNAL   Sci Rep 15 (1), 14017 (2025)
   PUBMED   40269054
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Ham,D.J., Semeraro,M., Berger,B.M., McGowan,T.J., Lin,S., Maino,E.,
            Oliveri,F. and Ruegg,M.A.
  TITLE     Muscle fiber Myc is dispensable for muscle growth and its forced
            expression severely perturbs homeostasis
  JOURNAL   Nat Commun 16 (1), 3190 (2025)
   PUBMED   40180928
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Balnis,J., Jackson,E.L., Drake,L.A., Singer,D.V., Bossardi
            Ramos,R., Singer,H.A. and Jaitovich,A.
  TITLE     Rapamycin improves satellite cells' autophagy and muscle
            regeneration during hypercapnia
  JOURNAL   JCI Insight 10 (1), e182842 (2025)
   PUBMED   39589836
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Hill,R.E. and Hanson,I.M.
  TITLE     Molecular genetics of the Pax gene family
  JOURNAL   Curr Opin Cell Biol 4 (6), 967-972 (1992)
   PUBMED   1485966
  REMARK    Review article
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Weydert,A., Cloez-Tayarani,I., Fillion,M.P., Simon-Chazottes,D.,
            Guenet,J.L. and Fillion,G.
  TITLE     Molecular cloning of two partial serotonin 5-HT1D receptor
            sequences in mouse and one in guinea pig
  JOURNAL   C R Acad Sci III 314 (10), 429-435 (1992)
   PUBMED   1521164
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Jostes,B., Walther,C. and Gruss,P.
  TITLE     The murine paired box gene, Pax7, is expressed specifically during
            the development of the nervous and muscular system
  JOURNAL   Mech Dev 33 (1), 27-37 (1990)
   PUBMED   1982921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844480.29 and AL831790.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4795858.1,
                                           SRR7345562.3222161.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.83 cM"
     Protein         1..503
                     /product="paired box protein Pax-7"
                     /note="paired box transcription factor PAX7; paired box
                     gene 7"
                     /calculated_mol_wt=54808
     Region          27..208
                     /region_name="Sufficient to mediate interaction with
                     PAXBP1. /evidence=ECO:0000269|PubMed:22862948"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Region          34..159
                     /region_name="PAX"
                     /note="Paired Box domain; smart00351"
                     /db_xref="CDD:128645"
     Region          37..93
                     /region_name="PAI subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Site            order(39..40,45,47..49,51,56,68,70,79,82,84..85,89,
                     98..104,106..107,109..110,129..131,150,152..153,156,159)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     Site            105
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:34059674; propagated from
                     UniProtKB/Swiss-Prot (P47239.2)"
     Region          113..161
                     /region_name="RED subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Site            139
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:34059674; propagated from
                     UniProtKB/Swiss-Prot (P47239.2)"
     Region          165..221
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     Region          216..272
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          345..383
                     /region_name="Pax7"
                     /note="Paired box protein 7; pfam12360"
                     /db_xref="CDD:403540"
     Region          477..489
                     /region_name="OAR.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00138"
                     /note="propagated from UniProtKB/Swiss-Prot (P47239.2)"
     CDS             1..503
                     /gene="Pax7"
                     /gene_synonym="Pax-7"
                     /coded_by="NM_011039.3:36..1547"
                     /db_xref="CCDS:CCDS18850.1"
                     /db_xref="GeneID:18509"
                     /db_xref="MGI:MGI:97491"
ORIGIN      
        1 maalpgavpr mmrpgpgqny prtgfplevs tplgqgrvnq lggvfingrp lpnhirhkiv
       61 emahhgirpc visrqlrvsh gcvskilcry qetgsirpga iggskprqva tpdvekkiee
      121 ykrenpgmfs weirdrllkd ghcdrstvps vssisrvlri kfgkkeddee gdkkeedgek
      181 kakhsidgil gdkgnrldeg sdvesepdlp lkrkqrrsrt tftaeqleel ekaferthyp
      241 diytreelaq rtkltearvq vwfsnrrarw rkqaganqla afnhllpggf pptgmptlpp
      301 yqlpdstypt ttisqdggst vhrpqplpps tmhqgglaaa aaaadtssay garhsfssys
      361 dsfmnpgaps nhmnpvsngl spqvmsilsn psavppqpqa dfsisplhgg ldsassisas
      421 csqradsikp gdslptsqsy cpptysttgy svdpvagyqy sqygqtavdy laknvslstq
      481 rrmklgehsa vlgllpvetg qay
//
LOCUS       NP_001013801             354 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon-inducible protein AIM2 [Mus musculus].
ACCESSION   NP_001013801 XP_357160
VERSION     NP_001013801.2
DBSOURCE    REFSEQ: accession NM_001013779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 354)
  AUTHORS   Suresh Kumar Meena Kumari,M., Liu,P., Nitchman,M.S., Chaudhary,S.,
            Jump,K., Morales,Y., Miller,E.A., Shecter,I., Stadecker,M.J. and
            Kalantari,P.
  TITLE     NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell
            response to eggs of the helminth Schistosoma mansoni
  JOURNAL   PLoS Pathog 21 (3), e1012108 (2025)
   PUBMED   40100932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 354)
  AUTHORS   Senapati,S., Bertolini,T.B., Minnier,M.A., Yazicioglu,M.N.,
            Markusic,D.M., Zhang,R., Wicks,J., Nahvi,A., Herzog,R.W.,
            Walsh,M.C., Cejas,P.J. and Armour,S.M.
  TITLE     Inhibition of IFNAR-JAK signaling enhances tolerability and
            transgene expression of systemic non-viral DNA delivery
  JOURNAL   Mol Ther Nucleic Acids 36 (2), 102502 (2025)
   PUBMED   40206655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 354)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   4  (residues 1 to 354)
  AUTHORS   Cao,J., Roth,S., Zhang,S., Kopczak,A., Mami,S., Asare,Y.,
            Georgakis,M.K., Messerer,D., Horn,A., Shemer,R., Jacqmarcq,C.,
            Picot,A., Green,J.P., Schlegl,C., Li,X., Tomas,L., Dutsch,A.,
            Liman,T.G., Endres,M., Wernsdorf,S.R., Furle,C., Carofiglio,O.,
            Zhu,J., Brough,D., Hornung,V., Dichgans,M., Vivien,D., Schulz,C.,
            Dor,Y., Tiedt,S., Sager,H.B., Grosse,G.M. and Liesz,A.
  CONSRTM   DEMDAS Study Group
  TITLE     DNA-sensing inflammasomes cause recurrent atherosclerotic stroke
  JOURNAL   Nature 633 (8029), 433-441 (2024)
   PUBMED   39112714
REFERENCE   5  (residues 1 to 354)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   6  (residues 1 to 354)
  AUTHORS   Fernandes-Alnemri,T., Yu,J.W., Datta,P., Wu,J. and Alnemri,E.S.
  TITLE     AIM2 activates the inflammasome and cell death in response to
            cytoplasmic DNA
  JOURNAL   Nature 458 (7237), 509-513 (2009)
   PUBMED   19158676
  REMARK    GeneRIF: identification of AIM2 as an important inflammasome
            component that senses potentially dangerous cytoplasmic DNA,
            leading to activation of the ASC pyroptosome and caspase-1
REFERENCE   7  (residues 1 to 354)
  AUTHORS   Hornung,V., Ablasser,A., Charrel-Dennis,M., Bauernfeind,F.,
            Horvath,G., Caffrey,D.R., Latz,E. and Fitzgerald,K.A.
  TITLE     AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating
            inflammasome with ASC
  JOURNAL   Nature 458 (7237), 514-518 (2009)
   PUBMED   19158675
  REMARK    GeneRIF: observations identify AIM2 as a new receptor for
            cytoplasmic DNA, which forms an inflammasome with the ligand and
            ASC to activate caspase-1
REFERENCE   8  (residues 1 to 354)
  AUTHORS   Roberts,T.L., Idris,A., Dunn,J.A., Kelly,G.M., Burnton,C.M.,
            Hodgson,S., Hardy,L.L., Garceau,V., Sweet,M.J., Ross,I.L.,
            Hume,D.A. and Stacey,K.J.
  TITLE     HIN-200 proteins regulate caspase activation in response to foreign
            cytoplasmic DNA
  JOURNAL   Science 323 (5917), 1057-1060 (2009)
   PUBMED   19131592
  REMARK    GeneRIF: study showed p202 is an inhibitor of DNA-induced caspase
            activation; conversely AIM2 was required for caspase activation by
            cytoplasmic dsDNA; work indicates HIN-200 proteins can act as
            pattern recognition receptors mediating response to cytoplasmic
            dsDNA
REFERENCE   9  (residues 1 to 354)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   10 (residues 1 to 354)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084073.22, AK050724.1 and DT921984.1.
            
            On Dec 14, 2007 this sequence version replaced NP_001013801.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     Protein         1..354
                     /product="interferon-inducible protein AIM2"
                     /note="ifi-210; interferon-inducible protein 210;
                     interferon-inducible protein p210"
                     /calculated_mol_wt=40024
     Region          10..79
                     /region_name="Pyrin"
                     /note="a protein-protein interaction domain; cd08305"
                     /db_xref="CDD:260019"
     Region          95..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VJ1.2)"
     Region          156..321
                     /region_name="HIN"
                     /note="HIN-200/IF120x domain; pfam02760"
                     /db_xref="CDD:460680"
     CDS             1..354
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /coded_by="NM_001013779.2:455..1519"
                     /db_xref="CCDS:CCDS15529.2"
                     /db_xref="GeneID:383619"
                     /db_xref="MGI:MGI:2686159"
ORIGIN      
        1 meseyremll ltgldhitee elkrfkyfal tefqiarstl dvadrtelad hliqsagaas
       61 avtkainifq klnymhiana leekkkeaer klmtntkkrg tqkvenrsqa encsaasatr
      121 sdndfkeqaa tevcpqakpq kkqmvaeqea iredlqkdpl vvtvlkainp fecetqegrq
      181 eifhatvate tdfffvkvln aqfkdkfipk rtikisnylw hsnfmevtss svvvdvesnh
      241 evpnnvvkra retprisklk iqpcgtivng lfkvqkitee kdrvlygihd ktgtmevlvl
      301 gnpsktkcee gdkirltffe vskngvkiql ksgpcsffkv ikaakpktdm ksve
//
LOCUS       NP_899198                430 aa            linear   ROD 27-AUG-2025
DEFINITION  pre-B-cell leukemia transcription factor 1 isoform a [Mus
            musculus].
ACCESSION   NP_899198
VERSION     NP_899198.1
DBSOURCE    REFSEQ: accession NM_183355.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Menezes,N.A., Peterson,K.J., Guo,X., Castiglioni,V., Kalvisa,A.,
            Filimonow,K., Schachter,K., Schuh,C.M., Pasias,A., Mariani,L.,
            Brickman,J.M., Sedzinski,J. and Ferretti,E.
  TITLE     Cell-context response to germ layer differentiation signals is
            predetermined by the epigenome in regionalized epiblast populations
  JOURNAL   Nat Commun 16 (1), 5000 (2025)
   PUBMED   40442089
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Wu,M.L., Wheeler,K., Silasi,R., Lupu,F. and Griffin,C.T.
  TITLE     Endothelial Chromatin-Remodeling Enzymes Regulate the Production of
            Critical ECM Components During Murine Lung Development
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (8), 1784-1798 (2024)
   PUBMED   38868942
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Wang,F.C., Zhang,X.N., Wu,S.X., He,Z., Zhang,L.Y. and Yang,Q.E.
  TITLE     Loss of PBX1 function in Leydig cells causes testicular dysgenesis
            and male sterility
  JOURNAL   Cell Mol Life Sci 81 (1), 212 (2024)
   PUBMED   38724675
  REMARK    GeneRIF: Loss of PBX1 function in Leydig cells causes testicular
            dysgenesis and male sterility.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J Immunol 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Pbx1 is a novel lupus susceptibility gene that regulates T
            cell activation and tolerance.
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Knoepfler,P.S. and Kamps,M.P.
  TITLE     The pentapeptide motif of Hox proteins is required for cooperative
            DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA
            binding by Pbx1
  JOURNAL   Mol Cell Biol 15 (10), 5811-5819 (1995)
   PUBMED   7565734
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Kagawa,N., Ogo,A., Takahashi,Y., Iwamatsu,A. and Waterman,M.R.
  TITLE     A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for
            the homeodomain protein Pbx1
  JOURNAL   J Biol Chem 269 (29), 18716-18719 (1994)
   PUBMED   7913464
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK144346.1, BC058390.1,
            AC116129.13 and AK083616.1.
            
            Summary: This gene encodes a homeobox protein that belongs to the
            three-amino-acid loop extension/Pre-B cell leukemia transcription
            factor (TALE/PBX) family of proteins. The encoded protein is
            involved in several biological processes during embryogenesis
            including steroidogenesis, sexual development and the maintenance
            of hematopoietic stem cells. This protein functions in the
            development of several organ systems and plays a role in skeletal
            patterning and programming. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058390.1, AF020196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 75.95 cM"
     Protein         1..430
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform a"
                     /note="pre-B-cell leukemia transcription factor 1;
                     homeobox protein PBX1"
                     /calculated_mol_wt=46495
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          42..232
                     /region_name="PBC"
                     /note="PBC domain; pfam03792"
                     /db_xref="CDD:461052"
     Region          45..124
                     /region_name="PBC-A.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          127..232
                     /region_name="PBC-B.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          234..294
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(234..238,240,260,266,279,281..282,285..286,288..290,
                     292..293)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(236,239,282,285..286,289)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            286
                     /site_type="other"
                     /note="Required for binding to the NFIL3 promoter.
                     /evidence=ECO:0000269|PubMed:32190943; propagated from
                     UniProtKB/Swiss-Prot (P41778.2)"
     Region          317..338
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          395..430
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     CDS             1..430
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /coded_by="NM_183355.3:666..1958"
                     /note="isoform a is encoded by transcript variant a"
                     /db_xref="CCDS:CCDS15461.1"
                     /db_xref="GeneID:18514"
                     /db_xref="MGI:MGI:97495"
ORIGIN      
        1 mdeqprlmhs hagvgmaghp glsqhlqdga ggtegeggrk qdigdilqqi mtitdqslde
       61 aqarkhalnc hrmkpalfnv lceikektvl sirgaqeeep tdpqlmrldn mllaegvagp
      121 ekgggsaaaa aaaaasggag sdnsvehsdy raklsqirqi yhtelekyeq acneftthvm
      181 nllreqsrtr pispkeierm vsiihrkfss iqmqlkqstc eavmilrsrf ldarrkrrnf
      241 nkqateilne yfyshlsnpy pseeakeela kkcgitvsqv snwfgnkrir ykknigkfqe
      301 eaniyaakta vtatnvsahg sqanspstpn sagssssfnm snsgdlfmsv qslngdsyqg
      361 aqvganvqsq vdtlrhvisq tggysdglaa sqmyspqgis anggwqdatt pssvtspteg
      421 pgsvhsdtsn
//
LOCUS       NP_001396614            1209 aa            linear   ROD 27-AUG-2025
DEFINITION  protein jagged-2 isoform 2 precursor [Mus musculus].
ACCESSION   NP_001396614 XP_006515549
VERSION     NP_001396614.1
DBSOURCE    REFSEQ: accession NM_001409685.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1209)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   2  (residues 1 to 1209)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Fan,G., Zhang,S., Zhao,L., Wu,C.L.,
            Guo,H., Huyen,T.L.N., Zheng,Y., Fan,Z.C., Shou,W., Schwartz,R.J.,
            Liu,Y., Kumar,A., Sui,H., Serysheva,I.I., Burns,A.R., Wan,L.Q.,
            Zhou,B., Evans,S.M. and Wu,M.
  TITLE     Tunneling nanotube-like structures regulate distant cellular
            interactions during heart formation
  JOURNAL   Science 387 (6739), eadd3417 (2025)
   PUBMED   40080583
REFERENCE   3  (residues 1 to 1209)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1209)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (residues 1 to 1209)
  AUTHORS   Huang,H., Jiang,Y., Liu,J., Luo,D., Yuan,J., Mu,R., Yu,X., Sun,D.,
            Lin,J., Chen,Q., Li,X., Jiang,M., Xu,J., Chu,B., Yin,C., Zhang,L.,
            Ye,Y., Cao,B., Wang,Q. and Zhang,Y.
  TITLE     Jag1/2 maintain esophageal homeostasis and suppress foregut
            tumorigenesis by restricting the basal progenitor cell pool
  JOURNAL   Nat Commun 15 (1), 4124 (2024)
   PUBMED   38750026
  REMARK    GeneRIF: Jag1/2 maintain esophageal homeostasis and suppress
            foregut tumorigenesis by restricting the basal progenitor cell
            pool.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1209)
  AUTHORS   Luo,B., Aster,J.C., Hasserjian,R.P., Kuo,F. and Sklar,J.
  TITLE     Isolation and functional analysis of a cDNA for human Jagged2, a
            gene encoding a ligand for the Notch1 receptor
  JOURNAL   Mol Cell Biol 17 (10), 6057-6067 (1997)
   PUBMED   9315665
REFERENCE   7  (residues 1 to 1209)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
REFERENCE   8  (residues 1 to 1209)
  AUTHORS   Shawber,C., Boulter,J., Lindsell,C.E. and Weinmaster,G.
  TITLE     Jagged2: a serrate-like gene expressed during rat embryogenesis
  JOURNAL   Dev Biol 180 (1), 370-376 (1996)
   PUBMED   8948600
REFERENCE   9  (residues 1 to 1209)
  AUTHORS   Burmeister,M., Novak,J., Liang,M.Y., Basu,S., Ploder,L.,
            Hawes,N.L., Vidgen,D., Hoover,F., Goldman,D., Kalnins,V.I.,
            Roderick,T.H., Taylor,B.A., Hankin,M.H. and McInnes,R.R.
  TITLE     Ocular retardation mouse caused by Chx10 homeobox null allele:
            impaired retinal progenitor proliferation and bipolar cell
            differentiation
  JOURNAL   Nat Genet 12 (4), 376-384 (1996)
   PUBMED   8630490
REFERENCE   10 (residues 1 to 1209)
  AUTHORS   Milaire,J.
  TITLE     Histochemical observations on the developing foot of normal,
            oligosyndactylous (Os-plus) and syndactylous (sm-sm) mouse embryos
  JOURNAL   Arch Biol (Liege) 78 (2), 223-288 (1967)
   PUBMED   4305644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160929.2.
            
            On Jul 21, 2022 this sequence version replaced XP_006515549.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.12485.1,
                                           SRR14995045.183250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.37 cM"
     Protein         1..1209
                     /product="protein jagged-2 isoform 2 precursor"
                     /note="protein jagged-2; syndactylism"
                     /calculated_mol_wt=127596
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3046
     Region          28..196
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Region          178..240
                     /region_name="DSL"
                     /note="delta serrate ligand; smart00051"
                     /db_xref="CDD:128366"
     Region          307..345
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(307,310,325)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          351..381
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          385..421
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(385,388,402)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          423..458
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(423,426,439)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          462..496
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          498..533
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(498,501,515)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          598..633
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(598,601,615)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          638..671
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          678..708
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          719..749
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          <759..786
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          789..825
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(789,792,806)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          834..905
                     /region_name="VWC_out"
                     /note="von Willebrand factor (vWF) type C domain;
                     smart00215"
                     /db_xref="CDD:214565"
     CDS             1..1209
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /coded_by="NM_001409685.1:334..3963"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:16450"
                     /db_xref="MGI:MGI:1098270"
ORIGIN      
        1 mrargwgrlp rrlllllvlc vqatrpmgyf elqlsalrnv ngellsgacc dgdgrttrag
       61 gcgrdecdty vrvclkeyqa kvtptgpcsy gygatpvlgg nsfylppaga agdrararsr
      121 tgghqdpglv vipfqfawpr sftliveawd wdndttpdee lliervshag minpedrwks
      181 lhfsghvahl elqirvrcde nyysatcnkf crprndffgh ytcdqygnka cmdgwmgkec
      241 keavckqgcn llhggctvpg ecrcsygwqg kfcdecvpyp gcvhgscvep whcdcetnwg
      301 gllcdkdlny cgshhpcvng gtcinaepdq ylcacpdgyl gknceraeha casnpcangg
      361 schevpsgfe chcpsgwngp tcaldideca snpcaaggtc vdqvdgfeci cpeqwvgatc
      421 qldindchgq cqhggtckdl vngyqcvcpr gfggrhcele ydkcasspcr rggicedlvd
      481 gfrchcprgl sglhcevdmd lcepspclng arcynlegdy ycacpedfgg kncsvprdtc
      541 pggacrvidg cgfeagsrar gvapsgicgp hghcvslpgg nfscicdsgf tgtychenid
      601 dcmgqpcrng gtcidevdsf rcfcpsgweg elcdinpndc lpdpchsrgr cydlvndfyc
      661 acddgwkgkt chsrefqcda ytcsnggtcy dsgdtfrcac ppgwkgstct iaknsscvpn
      721 pcvnggtcvg sgdsfscicr dgwegrtcth ntndcnplpc ynggicvdgv nwfrcecapg
      781 fagpdcrini decqsspcay gatcvdeing yrcscppgrs gprcqevvif trpcwsrgms
      841 fphgsswmed cnscrcldgh rdcskvwcgw kpcllsgqps dpsaqcppgq qcqekavgqc
      901 lqppcenwge ctaeeplpps tpcqprsshl dnncarltlr fnrdqvpqgt tvgaicsgir
      961 alpatraaah drlllllcdr assgasavev avsfspardl pdssliqsta haivaaitqr
     1021 gnsslllavt evkvetvvmg gsstgllvpv lcsvfsvlwl acvvicvwwt rkrrkerers
     1081 rlprdesann qwaplnpirn pierpggsgl gtgghkdily qcknftpppr ragealpgpa
     1141 ghgaggedee deelsrgdgd speaekfish kftkdpscsl grparwapgp kvdnravrst
     1201 kdvrragre
//
LOCUS       NP_001398585             854 aa            linear   ROD 27-AUG-2025
DEFINITION  autotaxin isoform 10 [Mus musculus].
ACCESSION   NP_001398585 XP_006520659
VERSION     NP_001398585.1
DBSOURCE    REFSEQ: accession NM_001411656.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 854)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 854)
  AUTHORS   Dacheux,M.A., Norman,D.D., Shin,Y., Tigyi,G.J. and Lee,S.C.
  TITLE     Deleting autotaxin in LysM+ myeloid cells impairs innate tumor
            immunity in models of metastatic melanoma
  JOURNAL   iScience 27 (10), 110971 (2024)
   PUBMED   39398245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 854)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   4  (residues 1 to 854)
  AUTHORS   Petersen-Cherubini,C.L., Liu,Y., Deffenbaugh,J.L., Murphy,S.P.,
            Xin,M., Rau,C.N., Yang,Y. and Lovett-Racke,A.E.
  TITLE     Dysregulated autotaxin expression by T cells in multiple sclerosis
  JOURNAL   J Neuroimmunol 387, 578282 (2024)
   PUBMED   38183947
  REMARK    GeneRIF: Dysregulated autotaxin expression by T cells in multiple
            sclerosis.
REFERENCE   5  (residues 1 to 854)
  AUTHORS   Giganti,A., Rodriguez,M., Fould,B., Moulharat,N., Coge,F.,
            Chomarat,P., Galizzi,J.P., Valet,P., Saulnier-Blache,J.S.,
            Boutin,J.A. and Ferry,G.
  TITLE     Murine and human autotaxin alpha, beta, and gamma isoforms: gene
            organization, tissue distribution, and biochemical characterization
  JOURNAL   J Biol Chem 283 (12), 7776-7789 (2008)
   PUBMED   18175805
  REMARK    GeneRIF: Murine and human autotaxin alpha, beta, and gamma
            isoforms: gene organization, tissue distribution, and biochemical
            characterization.
REFERENCE   6  (residues 1 to 854)
  AUTHORS   Koike,S., Keino-Masu,K., Ohto,T. and Masu,M.
  TITLE     The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions
            as a signal peptide
  JOURNAL   Genes Cells 11 (2), 133-142 (2006)
   PUBMED   16436050
REFERENCE   7  (residues 1 to 854)
  AUTHORS   Jansen,S., Stefan,C., Creemers,J.W., Waelkens,E., Van Eynde,A.,
            Stalmans,W. and Bollen,M.
  TITLE     Proteolytic maturation and activation of autotaxin (NPP2), a
            secreted metastasis-enhancing lysophospholipase D
  JOURNAL   J Cell Sci 118 (Pt 14), 3081-3089 (2005)
   PUBMED   15985467
REFERENCE   8  (residues 1 to 854)
  AUTHORS   Bachner,D., Ahrens,M., Betat,N., Schroder,D. and Gross,G.
  TITLE     Developmental expression analysis of murine autotaxin (ATX)
  JOURNAL   Mech Dev 84 (1-2), 121-125 (1999)
   PUBMED   10473125
REFERENCE   9  (residues 1 to 854)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (residues 1 to 854)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123644.8.
            
            On Aug 30, 2022 this sequence version replaced XP_006520659.1.
            
            Summary: This gene encodes a member of the phosphodiesterase and
            nucleotide pyrophosphatase family of bifunctional enzymes that
            hydrolize phosphodiester bonds of various nucleotides. The encoded
            protein undergoes proteolytic processing to generate a mature
            protein with lysophospholipase D activity, catalyzing the cleavage
            of the choline group from lysophosphatidylcholine to produce
            lysophosphatidic acid. This gene is expressed in numerous tissues
            and participates in neural development, obesity, inflammation and
            oncogenesis. A complete lack of the encoded protein in mice results
            in aberrant vascular and neuronal development leading to embryonic
            lethality. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (10) uses an alternate exon 1,
            uses an alternate in-frame splice site in the central coding
            region, and lacks an in-frame exon, compared to variant 1. The
            encoded isoform (10) has a distinct N-terminus and is shorter,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2641096.1,
                                           SRR17784643.519306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.6 cM"
     Protein         1..854
                     /product="autotaxin isoform 10"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; autotaxin; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2"
                     /calculated_mol_wt=97867
     Region          52..93
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          94..137
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          161..473
                     /region_name="Phosphodiest"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; pfam01663"
                     /db_xref="CDD:396300"
     Site            order(167,204..205,226,307,311,354..355,470)
                     /site_type="active"
                     /db_xref="CDD:293742"
     Site            order(167,204..205,226,307,311,355,470)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293742"
     Site            495..497
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:293742"
     Region          606..836
                     /region_name="NUC"
                     /note="DNA/RNA non-specific endonuclease; smart00477"
                     /db_xref="CDD:214683"
     Site            order(668..669,671,708,712)
                     /site_type="active"
                     /db_xref="CDD:238043"
     Site            order(668..669,712)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238043"
     CDS             1..854
                     /gene="Enpp2"
                     /gene_synonym="ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha;
                     Pdnp2"
                     /coded_by="NM_001411656.1:107..2671"
                     /note="isoform 10 is encoded by transcript variant 10"
                     /db_xref="GeneID:18606"
                     /db_xref="MGI:MGI:1321390"
ORIGIN      
        1 msrhadpvis lftfaigvnl clgftasrik raewdegppt vlsdspwtnt sgsckgrcfe
       61 lqevgppdcr cdnlcksyss cchdfdelcl ktargwectk drcgevrnee nachcsedcl
      121 srgdcctnyq vvckgeshwv dddceeirvp ecpagfvrpp liifsvdgfr asymkkgskv
      181 mpnieklrsc gthapymrpv yptktfpnly tlatglypes hgivgnsmyd pvfdatfhlr
      241 grekfnhrww ggqplwitat kqgvragtff wsvsipherr iltilqwlsl pdnerpsvya
      301 fyseqpdfsg hkygpfgpem tnplreidkt vgqlmdglkq lklhrcvnvi fvgdhgmedv
      361 tcdrteflsn yltnvdditl vpgtlgrirp kipnnlkydp kaiianltck kpdqhfkpym
      421 kqhlpkrlhy annrriedlh llverrwhva rkpldvykkp sgkcffqgdh gfdnkvnsmq
      481 tvfvgygptf kyrtkvppfe nielynvmcd llglkpapnn gthgslnhll rtntfrptlp
      541 eevsrpnypg imylqsdfdl gctcddknkl eelnkrlhtk gsteerhlly grpavlyrts
      601 ydilyhtdfe sgyseiflmp lwtsytiskq aevssipehl tncvrpdvrv spgfsqncla
      661 ykndkqmsyg flfppylsss peakydaflv tnmvpmypaf krvwtyfqrv lvkkyasern
      721 gvnvisgpif dynynglrdi edeikqyveg ssipvpthyy siitscldft qpadkcdgpl
      781 svssfilphr pdndescnss edeskwveel mkmhtarvrd iehltgldfy rktsrsysei
      841 ltlktylhty esei
//
LOCUS       NP_001342184             202 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform c [Mus musculus].
ACCESSION   NP_001342184
VERSION     NP_001342184.1
DBSOURCE    REFSEQ: accession NM_001355255.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 202)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 202)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 202)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 202)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 202)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 202)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 202)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 202)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 202)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 202)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice junction and lacks an in-frame exon but contains a different
            in-frame exon in the central coding region, compared to variant 1.
            The encoded isoform (d) is the same length but contains an
            alternate internal segment, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU604911.1, SRR7652917.953840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..202
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..202
                     /product="synaptosomal-associated protein 25 isoform c"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=22754
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..138
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          139..197
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(139,141..142,145..150,152..153,156..157,159..161,
                     163..164,167..168,170..171,173..178,180..181,184,187,191,
                     194,197)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            170
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     CDS             1..202
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001355255.2:210..818"
                     /note="isoform c is encoded by transcript variant 4"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqleri
       61 eegmdqinkd mkeaeknltd lgkfcglcvc pcnndaykka wgnnqdgvva sqparvvder
      121 eqmaisggfi rrvtndaren emdenleqvs giignlrhma ldmgneidtq nrqidrimek
      181 adsnktride anqratkmlg sg
//
LOCUS       NP_001399020             568 aa            linear   ROD 27-AUG-2025
DEFINITION  fragile X messenger ribonucleoprotein 1 isoform 6 [Mus musculus].
ACCESSION   NP_001399020 XP_006527877
VERSION     NP_001399020.1
DBSOURCE    REFSEQ: accession NM_001412091.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 568)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 568)
  AUTHORS   Wang,Z.H., Xu,C., Ma,Y.Y., Xue,W.X., Wang,H.Y., Fan,L.Y.,
            Zhang,C.Y., Li,L., Zhang,X.Y., Zhu,J.N. and Zhang,Q.P.
  TITLE     Oxytocin Improves Autistic Behaviors by Positively Shifting GABA
            Reversal Potential via NKCC1 in Early-Postnatal-Stage
  JOURNAL   Adv Sci (Weinh) 12 (21), e2415432 (2025)
   PUBMED   40305761
REFERENCE   3  (residues 1 to 568)
  AUTHORS   Jing,P.B., Zhou,Y.W., Zhang,F.M., Ge,J.Y., Wu,J.N., Xu,J.H.,
            Cao,X.H., Chang,N., Zhou,X., Luo,L. and Liu,X.J.
  TITLE     Autistic-like behaviors and impaired chronic inflammatory pain in
            primary nociceptive neuron-specific deletion of Mecp2 or Fmr1
            knockout male mice
  JOURNAL   Behav Brain Res 486, 115570 (2025)
   PUBMED   40174753
REFERENCE   4  (residues 1 to 568)
  AUTHORS   Lee,Y., Ishikawa,T., Lee,H., Lee,B., Ryu,C., Davila Mejia,I.,
            Kim,M., Lu,G., Hong,Y., Feng,M., Shin,H., Meloche,S.,
            Locksley,R.M., Koltsova,E., Grivennikov,S.I., Heiman,M., Choi,G.B.
            and Huh,J.R.
  TITLE     Brain-wide mapping of immune receptors uncovers a neuromodulatory
            role of IL-17E and the receptor IL-17RB
  JOURNAL   Cell 188 (8), 2203-2217 (2025)
   PUBMED   40199322
REFERENCE   5  (residues 1 to 568)
  AUTHORS   Hooshmandi,M., Ho-Tieng,D., Lister,K.C., Cai,W., Wong,C., Brown,N.,
            Fan,J., Hovhannisyan,V., Uttam,S., Prager-Khoutorsky,M.,
            Sonenberg,N., Gkogkas,C.G. and Khoutorsky,A.
  TITLE     Postnatal downregulation of Fmr1 in microglia promotes microglial
            reactivity and causes behavioural alterations in female mice
  JOURNAL   Mol Autism 16 (1), 17 (2025)
   PUBMED   40055803
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 568)
  AUTHORS   Verheij,C., de Graaff,E., Bakker,C.E., Willemsen,R., Willems,P.J.,
            Meijer,N., Galjaard,H., Reuser,A.J., Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Characterization of FMR1 proteins isolated from different tissues
  JOURNAL   Hum Mol Genet 4 (5), 895-901 (1995)
   PUBMED   7633450
REFERENCE   7  (residues 1 to 568)
  AUTHORS   Khandjian,E.W., Fortin,A., Thibodeau,A., Tremblay,S., Cote,F.,
            Devys,D., Mandel,J.L. and Rousseau,F.
  TITLE     A heterogeneous set of FMR1 proteins is widely distributed in mouse
            tissues and is modulated in cell culture
  JOURNAL   Hum Mol Genet 4 (5), 783-789 (1995)
   PUBMED   7633436
REFERENCE   8  (residues 1 to 568)
  AUTHORS   Laval,S.H., Blair,H.J., Hirst,M.C., Davies,K.E. and Boyd,Y.
  TITLE     Mapping of FMR1, the gene implicated in fragile X-linked mental
            retardation, on the mouse X chromosome
  JOURNAL   Genomics 12 (4), 818-821 (1992)
   PUBMED   1572655
REFERENCE   9  (residues 1 to 568)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (residues 1 to 568)
  AUTHORS   Mandel,J.L., Arveiler,B., Camerino,G., Hanauer,A., Heilig,R.,
            Koenig,M. and Oberle,I.
  TITLE     Genetic mapping of the human X chromosome: linkage analysis of the
            q26-q28 region that includes the fragile X locus and isolation of
            expressed sequences
  JOURNAL   Cold Spring Harb Symp Quant Biol 51 Pt 1, 195-203 (1986)
   PUBMED   3472716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055766.31.
            
            On Sep 14, 2022 this sequence version replaced XP_006527877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.73295.1,
                                           SRR9219380.38390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.83 cM"
     Protein         1..568
                     /product="fragile X messenger ribonucleoprotein 1 isoform
                     6"
                     /note="FMRP translational regulator 1; synaptic functional
                     regulator FMR1"
                     /calculated_mol_wt=63867
     Region          1..55
                     /region_name="Tudor_Agenet_FMR1_rpt1"
                     /note="first Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20471"
                     /db_xref="CDD:410542"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410542"
     Region          58..120
                     /region_name="Tudor_Agenet_FMR1_rpt2"
                     /note="second Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20474"
                     /db_xref="CDD:410545"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410545"
     Region          123..199
                     /region_name="KH_I_FMR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22506"
                     /db_xref="CDD:411934"
     Region          218..280
                     /region_name="KH_I_FMR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22509"
                     /db_xref="CDD:411937"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411937"
     Region          281..402
                     /region_name="KH_I_FMR1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22512"
                     /db_xref="CDD:411940"
     Site            order(290..294,297,300..301,305,308..309,312..323,325)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:411940"
     Site            order(291,293..295,297..301,304..305,308..309,315..318)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411940"
     Region          398..>469
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:463501"
     Region          503..568
                     /region_name="FXMR_C2"
                     /note="Fragile X-related mental retardation protein
                     C-terminal region 2; pfam16098"
                     /db_xref="CDD:465020"
     CDS             1..568
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /coded_by="NM_001412091.1:236..1942"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:14265"
                     /db_xref="MGI:MGI:95564"
ORIGIN      
        1 meelvvevrg sngafykafv kdvhedsitv afennwqper qipfhdvrfp ppvgynkdin
       61 esdevevysr anekepccww lakvrmikge fyvieyaacd atyneivtie rlrsvnpnkp
      121 atkdtfhkik levpedlrqm cakesahkdf kkavgafsvt ydpenyqlvi lsinevtskr
      181 ahmlidmhfr slrtklslil rneeaskqle ssrqlasrfh eqfivredlm glaigthgan
      241 iqqarkvpgv taidldedtc tfhiygedqd avkkarsfle faedviqvpr nlvgkvigkn
      301 gkliqeivdk sgvvrvriea eneksvpqee eimppsslps nnsrvgpnss eekkhldtke
      361 nthfsqpnst kvqrgmvpfv fvgtkdsian atvlldyhln ylkevdqlrl erlqideqlr
      421 qigassrppp nrtdkekgyv tddgqgmgrg srpyrnrghg rrgpgytsap teeeresflr
      481 rgdgrrrggg grgqggrgrg ggfkgnddhs rtdnrprnpr eakgrtadgs lqsassegsr
      541 lrtgkdrnqk kekpdsvdgl qplvngvp
//
LOCUS       NP_035461                104 aa            linear   ROD 27-AUG-2025
DEFINITION  C-C motif chemokine 12 precursor [Mus musculus].
ACCESSION   NP_035461 XP_001480941 XP_001480942 XP_001480943
VERSION     NP_035461.2
DBSOURCE    REFSEQ: accession NM_011331.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 104)
  AUTHORS   Ross,J.L., Puigdelloses-Vallcorba,M., Pinero,G., Soni,N.,
            Thomason,W., DeSisto,J., Angione,A., Tsankova,N.M., Castro,M.G.,
            Schniederjan,M., Wadhwani,N.R., Raju,G.P., Morgenstern,P.,
            Becher,O.J., Green,A.L., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Microglia and monocyte-derived macrophages drive progression of
            pediatric high-grade gliomas and are transcriptionally shaped by
            histone mutations
  JOURNAL   Immunity 57 (11), 2669-2687 (2024)
   PUBMED   39395421
REFERENCE   2  (residues 1 to 104)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 104)
  AUTHORS   Sattiraju,A., Kang,S., Giotti,B., Chen,Z., Marallano,V.J.,
            Brusco,C., Ramakrishnan,A., Shen,L., Tsankov,A.M.,
            Hambardzumyan,D., Friedel,R.H. and Zou,H.
  TITLE     Hypoxic niches attract and sequester tumor-associated macrophages
            and cytotoxic T cells and reprogram them for immunosuppression
  JOURNAL   Immunity 56 (8), 1825-1843 (2023)
   PUBMED   37451265
REFERENCE   4  (residues 1 to 104)
  AUTHORS   Chen,Z., Soni,N., Pinero,G., Giotti,B., Eddins,D.J., Lindblad,K.E.,
            Ross,J.L., Puigdelloses Vallcorba,M., Joshi,T., Angione,A.,
            Thomason,W., Keane,A., Tsankova,N.M., Gutmann,D.H., Lira,S.A.,
            Lujambio,A., Ghosn,E.E.B., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Monocyte depletion enhances neutrophil influx and proneural to
            mesenchymal transition in glioblastoma
  JOURNAL   Nat Commun 14 (1), 1839 (2023)
   PUBMED   37012245
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 104)
  AUTHORS   Fang,Y., Fan,W., Xu,X., Janoshazi,A.K., Fargo,D.C. and Li,X.
  TITLE     SIRT1 regulates cardiomyocyte alignment during maturation
  JOURNAL   J Cell Sci 135 (7) (2022)
   PUBMED   35260907
REFERENCE   6  (residues 1 to 104)
  AUTHORS   Wagner,K., Dendorfer,U., Chilla,S., Schlondorff,D. and Luckow,B.
  TITLE     Identification of new regulatory sequences far upstream of the
            mouse monocyte chemoattractant protein-1 gene
  JOURNAL   Genomics 78 (3), 113-123 (2001)
   PUBMED   11735217
REFERENCE   7  (residues 1 to 104)
  AUTHORS   Cohen-Tannoudji,M., Vandormael-Pournin,S., Le Bras,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus
            region on mouse chromosome 11
  JOURNAL   Genomics 68 (3), 273-282 (2000)
   PUBMED   10995569
REFERENCE   8  (residues 1 to 104)
  AUTHORS   Teuscher,C., Butterfield,R.J., Ma,R.Z., Zachary,J.F., Doerge,R.W.
            and Blankenhorn,E.P.
  TITLE     Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2
            (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are
            candidates for eae7, a locus controlling susceptibility to
            monophasic remitting/nonrelapsing experimental allergic
            encephalomyelitis
  JOURNAL   J Immunol 163 (4), 2262-2266 (1999)
   PUBMED   10438970
REFERENCE   9  (residues 1 to 104)
  AUTHORS   Sarafi,M.N., Garcia-Zepeda,E.A., MacLean,J.A., Charo,I.F. and
            Luster,A.D.
  TITLE     Murine monocyte chemoattractant protein (MCP)-5: a novel CC
            chemokine that is a structural and functional homologue of human
            MCP-1
  JOURNAL   J Exp Med 185 (1), 99-109 (1997)
   PUBMED   8996246
REFERENCE   10 (residues 1 to 104)
  AUTHORS   Jia,G.Q., Gonzalo,J.A., Lloyd,C., Kremer,L., Lu,L., Martinez-A,C.,
            Wershil,B.K. and Gutierrez-Ramos,J.C.
  TITLE     Distinct expression and function of the novel mouse chemokine
            monocyte chemotactic protein-5 in lung allergic inflammation
  JOURNAL   J Exp Med 184 (5), 1939-1951 (1996)
   PUBMED   8920881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645596.7.
            
            On or before Sep 17, 2009 this sequence version replaced
            XP_001480941.1, XP_001480943.1, XP_001480942.1, NP_035461.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012356.1, U50712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..104
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 49.9 cM"
     Protein         1..104
                     /product="C-C motif chemokine 12 precursor"
                     /note="C-C motif chemokine 12; chemokine (C-C motif)
                     ligand 12; MCP-1-related chemokine; small-inducible
                     cytokine A12; monocyte chemotactic protein 5; monocyte
                     chemoattractant protein 5"
                     /calculated_mol_wt=9334
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2343
     mat_peptide     23..104
                     /product="C-C motif chemokine 12. /id=PRO_0000005199"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62401.1)"
                     /calculated_mol_wt=9334
     Region          30..89
                     /region_name="SCY"
                     /note="Intercrine alpha family (small cytokine C-X-C)
                     (chemokine CXC); smart00199"
                     /db_xref="CDD:197570"
     Site            order(33..37,39..46,57..58,80..90)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:238170"
     Site            order(35,37,50,52,58,63..65,73..75,81..82,85..86,89..90)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(35,37,55,57..58,64,72,74)
                     /site_type="other"
                     /note="dimer interface (P form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(35,64,73)
                     /site_type="active"
                     /note="putative receptor binding cleft [active]"
                     /db_xref="CDD:238170"
     Site            order(35..37,39..46)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238170"
     Site            order(37,50,52,63,65,73,75,81..82,85..86,89..90)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(39..41,44..46,69,71)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            order(52,60,78,80,83..84,87)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            57..58
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238170"
     Site            order(67,69)
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238170"
     CDS             1..104
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /coded_by="NM_011331.3:56..370"
                     /db_xref="CCDS:CCDS36247.1"
                     /db_xref="GeneID:20293"
                     /db_xref="MGI:MGI:108224"
ORIGIN      
        1 mkistllcll liattispqv lagpdavstp vtccynvvkq kihvrklksy rritssqcpr
       61 eavifrtild keicadpkek wvknsinhld ktsqtfilep sclg
//
LOCUS       NP_001408081             373 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform g [Mus musculus].
ACCESSION   NP_001408081 XP_006502865
VERSION     NP_001408081.1
DBSOURCE    REFSEQ: accession NM_001421152.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 373)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 373)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 373)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 373)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 373)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_006502865.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.1041241.1,
                                           SRR7345562.3375084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..373
                     /product="ELAV-like protein 4 isoform g"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40833
     Region          36..372
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..373
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421152.1:70..1191"
                     /note="isoform g is encoded by transcript variant 8"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mepqvsngpt sntsngpssn nrncpspmqt gaatddsktn livnylpqnm tqeefrslfg
       61 sigeiesckl vrdkitgqsl gygfvnyidp kdaekaintl nglrlqtkti kvsyarpssa
      121 sirdanlyvs glpktmtqke leqlfsqygr iitsrilvdq vtgvsrgvgf irfdkrieae
      181 eaikglngqk psgatepitv kfannpsqks sqallsqlyq spnrrypgpl hhqaqrfrld
      241 nllnmaygvk rlmsgpvpps acpprfspit idgmtslvgm nipghtgtgw cifvynlspd
      301 sdesvlwqlf gpfgavnnvk virdfntnkc kgfgfvtmtn ydeaamaias lngyrlgdrv
      361 lqvsfktnka hks
//
LOCUS       NP_033141                 92 aa            linear   ROD 27-AUG-2025
DEFINITION  protein S100-B [Mus musculus].
ACCESSION   NP_033141
VERSION     NP_033141.1
DBSOURCE    REFSEQ: accession NM_009115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 92)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 92)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 92)
  AUTHORS   Santiago,C., Siegrist,J., Africawala,N., Handler,A., Tasnim,A.,
            Anjum,R., Turecek,J., Lehnert,B.P., Renauld,S., Choi,J.,
            Nolan-Tamariz,M., Iskols,M., Magee,A.R., Paradis,S., Sharma,N. and
            Ginty,D.D.
  TITLE     Activity-dependent development of the body's touch receptors
  JOURNAL   Neuron 113 (11), 1758-1773 (2025)
   PUBMED   40381613
REFERENCE   4  (residues 1 to 92)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   5  (residues 1 to 92)
  AUTHORS   Bergamasco,M.I., Ozturk,E., Casillas-Espinosa,P.M., Garnham,A.L.,
            Abeysekera,W., Wimmer,V.C., Rajasekhar,P., Vanyai,H.K.,
            Whitehead,L., Blewitt,M.E., Rogers,K., Vogel,A.P., Hannan,A.J.,
            Smyth,G.K., Jones,N.C., Thomas,T. and Voss,A.K.
  TITLE     KAT6B overexpression in mice causes aggression, anxiety, and
            epilepsy
  JOURNAL   iScience 28 (3), 111953 (2025)
   PUBMED   40083716
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 92)
  AUTHORS   Shimizu,A., Sakai,Y., Ohno,K., Masaki,S., Kuwano,R., Takahashi,Y.,
            Miyashita,N. and Watanabe,T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   7  (residues 1 to 92)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   8  (residues 1 to 92)
  AUTHORS   MacDonald,G., Chu,M.L. and Cox,D.R.
  TITLE     Fine structure physical mapping of the region of mouse chromosome
            10 homologous to human chromosome 21
  JOURNAL   Genomics 11 (2), 317-323 (1991)
   PUBMED   1837533
REFERENCE   9  (residues 1 to 92)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (residues 1 to 92)
  AUTHORS   Naruse,I., Kato,K., Asano,T., Suzuki,F. and Kameyama,Y.
  TITLE     Developmental brain abnormalities accompanied with the retarded
            production of S-100 beta protein in genetic polydactyly mice
  JOURNAL   Brain Res Dev Brain Res 51 (2), 253-258 (1990)
   PUBMED   2323034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX205737.1, BC061178.1, AK135083.1 and AW456919.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX205737.1, AK135083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..92
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.76 cM"
     Protein         1..92
                     /product="protein S100-B"
                     /note="S-100 protein beta chain; S-100 protein subunit
                     beta; S100 calcium-binding protein B"
                     /calculated_mol_wt=10597
     Region          2..89
                     /region_name="S-100B"
                     /note="S-100B domain found in proteins similar to S100B.
                     S100B is a calcium-binding protein belonging to a large
                     S100 vertebrate-specific protein family within the EF-hand
                     superfamily of calcium-binding proteins. Note that the
                     S-100 hierarchy, to which this...; cd05027"
                     /db_xref="CDD:240154"
     Site            order(2..5,7..19,26,36,39..41,71..72,74..75,78..80,82..83,
                     87..89)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:240154"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P02638; propagated from
                     UniProtKB/Swiss-Prot (P50114.2)"
     Site            order(19,22,24,27,32,62,64,66,68,73)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:240154"
     Site            order(43..48,50,52..53,56..57,80..81,84..85,87..88)
                     /site_type="other"
                     /note="NDR kinase binding site [polypeptide binding]"
                     /db_xref="CDD:240154"
     Site            order(47,49,53,56..57,60,72,77,80..81,84..85,87..88)
                     /site_type="active"
                     /note="TRTK-12 binding site [active]"
                     /db_xref="CDD:240154"
     CDS             1..92
                     /gene="S100b"
                     /gene_synonym="Bpb"
                     /coded_by="NM_009115.3:132..410"
                     /db_xref="CCDS:CCDS35943.1"
                     /db_xref="GeneID:20203"
                     /db_xref="MGI:MGI:98217"
ORIGIN      
        1 mselekamva lidvfhqysg regdkhklkk selkelinne lshfleeike qevvdkvmet
       61 ldedgdgecd fqefmafvam vttacheffe he
//
LOCUS       NP_032579                231 aa            linear   ROD 27-AUG-2025
DEFINITION  achaete-scute homolog 1 [Mus musculus].
ACCESSION   NP_032579
VERSION     NP_032579.2
DBSOURCE    REFSEQ: accession NM_008553.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 231)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 231)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 231)
  AUTHORS   Duffie,R., Shayya,H., Escamilla Del Arenal,M., Wang,M., Kahiapo,J.,
            Ugurbil,A., Keskin,A., Clowney,F., Bashkirova,E.V.,
            Pourmorady,A.D., Schieren,I., Avila,H.I., Berchowitz,L.E.,
            Barriga,F.M., Batlle,E., Jovanovic,M. and Lomvardas,S.
  TITLE     Mex3a-dependent post-transcriptional silencing ensures olfactory
            receptor diversity and axon guidance specificity
  JOURNAL   Cell Rep 44 (8), 115979 (2025)
   PUBMED   40668674
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 231)
  AUTHORS   Wang,M., van Bruggen,R., Mohammed,L., Egor,K. and Tan,Q.
  TITLE     Loss of NFIA Impairs Adult Hippocampal Neurogenesis
  JOURNAL   Hippocampus 35 (4), e70016 (2025)
   PUBMED   40459218
REFERENCE   5  (residues 1 to 231)
  AUTHORS   Foote,A.G. and Sun,X.
  TITLE     Cellular heterogeneity and patterning strategies as revealed by
            upper respiratory epithelium single cell atlas
  JOURNAL   iScience 28 (7), 112845 (2025)
   PUBMED   40612507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 231)
  AUTHORS   Lee,J.E., Hollenberg,S.M., Snider,L., Turner,D.L., Lipnick,N. and
            Weintraub,H.
  TITLE     Conversion of Xenopus ectoderm into neurons by NeuroD, a basic
            helix-loop-helix protein
  JOURNAL   Science 268 (5212), 836-844 (1995)
   PUBMED   7754368
REFERENCE   7  (residues 1 to 231)
  AUTHORS   Conlon,R.A., Reaume,A.G. and Rossant,J.
  TITLE     Notch1 is required for the coordinate segmentation of somites
  JOURNAL   Development 121 (5), 1533-1545 (1995)
   PUBMED   7789282
REFERENCE   8  (residues 1 to 231)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
REFERENCE   9  (residues 1 to 231)
  AUTHORS   Johnson,J.E., Zimmerman,K., Saito,T. and Anderson,D.J.
  TITLE     Induction and repression of mammalian achaete-scute homologue
            (MASH) gene expression during neuronal differentiation of P19
            embryonal carcinoma cells
  JOURNAL   Development 114 (1), 75-87 (1992)
   PUBMED   1576967
REFERENCE   10 (residues 1 to 231)
  AUTHORS   Lo,L.C., Johnson,J.E., Wuenschell,C.W., Saito,T. and Anderson,D.J.
  TITLE     Mammalian achaete-scute homolog 1 is transiently expressed by
            spatially restricted subsets of early neuroepithelial and neural
            crest cells
  JOURNAL   Genes Dev 5 (9), 1524-1537 (1991)
   PUBMED   1909283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143210.1 and BX512680.1.
            
            On Dec 20, 2003 this sequence version replaced NP_032579.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143210.1, BC055748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.64 cM"
     Protein         1..231
                     /product="achaete-scute homolog 1"
                     /note="mammalian achaete scute homolog 1; achaete-scute
                     complex homolog-like 1; achaete-scute complex-like protein
                     1"
                     /calculated_mol_wt=24609
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02067.2)"
     Region          39..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02067.2)"
     Region          110..180
                     /region_name="bHLH_TS_ASCL1_Mash1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     achaete-scute-like protein 1 (ASCL-1) and similar
                     proteins; cd19742"
                     /db_xref="CDD:381585"
     Site            order(115,119,121..123,125,130,148..151)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381585"
     Site            order(128..129,132..133,135..136,152,155,159,161..162,166,
                     168..169)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381585"
     Site            151
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q02067.2)"
     CDS             1..231
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /coded_by="NM_008553.5:573..1268"
                     /db_xref="CCDS:CCDS24101.1"
                     /db_xref="GeneID:17172"
                     /db_xref="MGI:MGI:96919"
ORIGIN      
        1 messgkmesg agqqpqppqp flppaacffa taaaaaaaaa aaaqsaqqqq pqappqqapq
       61 lspvadsqps ggghksaakq vkrqrssspe lmrckrrlnf sgfgyslpqq qpaavarrne
      121 rernrvklvn lgfatlrehv pngaankkms kvetlrsave yiralqqlld ehdavsaafq
      181 agvlsptisp nysndlnsma gspvssyssd egsydplspe eqelldftnw f
//
LOCUS       NP_033160               1957 aa            linear   ROD 27-AUG-2025
DEFINITION  sodium channel protein type 10 subunit alpha isoform 2 [Mus
            musculus].
ACCESSION   NP_033160
VERSION     NP_033160.2
DBSOURCE    REFSEQ: accession NM_009134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1957)
  AUTHORS   Gupta,N., LoGrasso,G., Hazlett,L.D. and Xu,S.
  TITLE     New insight into the neuroimmune interplay in Pseudomonas
            aeruginosa keratitis
  JOURNAL   Ocul Surf 38, 170-183 (2025)
   PUBMED   40714297
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 1957)
  AUTHORS   Martinez-Padilla,A., Marquez,J., Huerta,M.A., Roza,C. and
            Cisneros,E.
  TITLE     Loss of Glutaminase 1 in Small Sensory Neurons Prevents Nerve
            Injury Induced Mechanical Allodynia: Insights From Conditional
            Knockout Mice
  JOURNAL   Eur J Pain 29 (6), e70069 (2025)
   PUBMED   40552835
REFERENCE   3  (residues 1 to 1957)
  AUTHORS   Santiago,C., Siegrist,J., Africawala,N., Handler,A., Tasnim,A.,
            Anjum,R., Turecek,J., Lehnert,B.P., Renauld,S., Choi,J.,
            Nolan-Tamariz,M., Iskols,M., Magee,A.R., Paradis,S., Sharma,N. and
            Ginty,D.D.
  TITLE     Activity-dependent development of the body's touch receptors
  JOURNAL   Neuron 113 (11), 1758-1773 (2025)
   PUBMED   40381613
REFERENCE   4  (residues 1 to 1957)
  AUTHORS   Passini,F.S., Bornstein,B., Rubin,S., Kuperman,Y., Krief,S.,
            Masschelein,E., Mehlman,T., Brandis,A., Addadi,Y., Shalom,S.H.,
            Richter,E.A., Yardeni,T., Tirosh,A., De Bock,K. and Zelzer,E.
  TITLE     Piezo2 in sensory neurons regulates systemic and adipose tissue
            metabolism
  JOURNAL   Cell Metab 37 (4), 987-1000 (2025)
   PUBMED   39919739
REFERENCE   5  (residues 1 to 1957)
  AUTHORS   Liu,D., Rahman,M., Johnson,A., Amo,R., Tsutsui-Kimura,I.,
            Sullivan,Z.A., Pena,N., Talay,M., Logeman,B.L., Finkbeiner,S.,
            Qian,L., Choi,S., Capo-Battaglia,A., Abdus-Saboor,I., Ginty,D.D.,
            Uchida,N., Watabe-Uchida,M. and Dulac,C.
  TITLE     A hypothalamic circuit underlying the dynamic control of social
            homeostasis
  JOURNAL   Nature 640 (8060), 1000-1010 (2025)
   PUBMED   40011768
REFERENCE   6  (residues 1 to 1957)
  AUTHORS   Ma,Q., Fode,C., Guillemot,F. and Anderson,D.J.
  TITLE     Neurogenin1 and neurogenin2 control two distinct waves of
            neurogenesis in developing dorsal root ganglia
  JOURNAL   Genes Dev 13 (13), 1717-1728 (1999)
   PUBMED   10398684
REFERENCE   7  (residues 1 to 1957)
  AUTHORS   Akopian,A.N., Souslova,V., England,S., Okuse,K., Ogata,N., Ure,J.,
            Smith,A., Kerr,B.J., McMahon,S.B., Boyce,S., Hill,R., Stanfa,L.C.,
            Dickenson,A.H. and Wood,J.N.
  TITLE     The tetrodotoxin-resistant sodium channel SNS has a specialized
            function in pain pathways
  JOURNAL   Nat Neurosci 2 (6), 541-548 (1999)
   PUBMED   10448219
REFERENCE   8  (residues 1 to 1957)
  AUTHORS   Gallo,R.L., Kim,K.J., Bernfield,M., Kozak,C.A., Zanetti,M.,
            Merluzzi,L. and Gennaro,R.
  TITLE     Identification of CRAMP, a cathelin-related antimicrobial peptide
            expressed in the embryonic and adult mouse
  JOURNAL   J Biol Chem 272 (20), 13088-13093 (1997)
   PUBMED   9148921
REFERENCE   9  (residues 1 to 1957)
  AUTHORS   Souslova,V.A., Fox,M., Wood,J.N. and Akopian,A.N.
  TITLE     Cloning and characterization of a mouse sensory neuron
            tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a
  JOURNAL   Genomics 41 (2), 201-209 (1997)
   PUBMED   9143495
REFERENCE   10 (residues 1 to 1957)
  AUTHORS   Kozak,C.A. and Sangameswaran,L.
  TITLE     Genetic mapping of the peripheral sodium channel genes, Scn9a and
            Scn10a, in the mouse
  JOURNAL   Mamm Genome 7 (10), 787-788 (1996)
   PUBMED   8854872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157866.1 and AC171201.1.
            
            On Mar 15, 2007 this sequence version replaced NP_033160.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     Protein         1..1957
                     /product="sodium channel protein type 10 subunit alpha
                     isoform 2"
                     /note="sodium channel protein type 10 subunit alpha;
                     sensory neuron sodium channel; peripheral nerve sodium
                     channel 3; sodium channel protein type X subunit alpha;
                     voltage-gated sodium channel subunit alpha Nav1.8; voltage
                     gated sodium channel"
                     /calculated_mol_wt=220294
     Region          27..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          116..404
                     /region_name="I. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            126..149
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          129..406
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            155..174
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            188..206
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            213..232
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            249..272
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            279
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            288
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            334
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            373..398
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          444..483
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          539..583
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            611
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            614
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          646..910
                     /region_name="II. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            659..683
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          663..893
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            695..718
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            727..746
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            753..772
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            789..809
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            864..889
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          903..1147
                     /region_name="Na_trans_assoc"
                     /note="Sodium ion transport-associated; pfam06512"
                     /db_xref="CDD:461936"
     Region          1140..1449
                     /region_name="III. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1148..1171
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          1151..1427
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            1185..1210
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1217..1238
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1243..1264
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1284..1311
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1322
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1328
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1336
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1392..1418
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          1419..1471
                     /region_name="Na_channel_gate"
                     /note="Inactivation gate of the voltage-gated sodium
                     channel alpha subunits; cd13433"
                     /db_xref="CDD:240441"
     Site            1433..1436
                     /site_type="other"
                     /note="putative hydrophobic latch"
                     /db_xref="CDD:240441"
     Site            1451
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:Q14524; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          1458..1757
                     /region_name="IV. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1472..1495
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          1475..1732
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            1499
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1507..1530
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1537..1560
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1573..1594
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1610..1632
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1686
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Site            1698..1722
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     Region          1900..1957
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QIY3.2)"
     CDS             1..1957
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /coded_by="NM_009134.3:71..5944"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS90682.1"
                     /db_xref="GeneID:20264"
                     /db_xref="MGI:MGI:108029"
ORIGIN      
        1 mefpfgsvgt tnfrrftpes laeiekqiaa hraakkgrpk qrgqkdksek prpqldlkac
       61 nqlprfygel paelvgeple dldpfysthr tfivldksrt isrfsatwal wlfspfnlir
      121 rtaikvsvhs wfsifitvti lvncvcmtrt dlpekleyaf tvvytfeali kilargfcln
      181 eftylrdpwn wldfsvitla yvgaaidlrg isglrtfrvl ralktvsvip glkvivgali
      241 hsvrkladvt iltvfclsvf alvglqlfkg nlknkcikng tdphkadnls semagdifik
      301 pgttdpllcg ngsdaghcpn dyvcrktsdn pdfnytsfds fawaflslfr lmtqdswerl
      361 yqqtlrasgk mymvffvlvi flgsfylvnl ilavvtmaye eqsqatiaei eakekkfkea
      421 levlqkeqev laalgidtts lyshngspla pknanerrpr vksrmsegst ddnrslqsdp
      481 ynqrrmsflg lssgrrrash ssvfhfraps qdvsfpdgil ddgvfhgdqe srrssillgr
      541 gagqagplpr splpqspnpg prrgeegqrg vptgelatga pegpaldaag qknflsadyl
      601 nepfraqram svvsimtsvi eeleesklkc ppclislaqk yliweccpkw kkfkmvlfel
      661 vtdpfaelti tlcivvntvf mamehypmtd afdamlqagn ivftvfftme mafkiiafdp
      721 yyyfqkkwni fdcvivtvsl lelstskkgs lsvlrtfrll rvfklakswp tlnmlikiig
      781 nsvgalgnlt filaiivfif alvgkqllse nygcrrdgis vwngerlrwh mcdffhsflv
      841 vfrilcgewi enmwvcmevs qdyicltlfl tvmvlgnlvv lnlfiallln sfsadnltap
      901 eddgevnnlq valariqvfg hrasraitsy irshcrlrwp kvetqlgmkp pltsckaenh
      961 iatdavnaav gnlakpalgg pkenhgdfit dpnvwvsvpi aegesdldel eedvehasqs
     1021 swqeespkgq ellqqvqkce dhqaarspps gmssedlapy lgerwqrees prvpaegvdd
     1081 tsssegstvd cpdpeeilrk ipelaeelde pddcfpegct rrcpcckvnt skfpwatgwq
     1141 vrktcyrive hswfesfiif millssgala fednyleekp rvksvleytd rvftfifvfe
     1201 mllkwvaygf kkyftnawcw ldflivnisl tsliakiley sdvasikalr tlralrplra
     1261 lsrfegmrvv vdalvgaips imnvllvcli fwlifsimgv nlfagkfsrc vdtrsnpfsv
     1321 vnstfvtnks dcynqnntgh ffwvnvkvnf dnvamgylal lqvatfkgwm dimyaavdsr
     1381 dinsqpnwee slymylyfvv fiifggfftl nlfvgviidn fnqqkkklgg qdifmteeqk
     1441 kyynamkklg skkpqkpipr plnkyqgfvf divtrqafdi iimaliclnm itmmvetdnq
     1501 seektkvlgr inqffvavft gecvmkmfal rqyyftngwn vfdfivvils issllfsail
     1561 sslesyfspt llrvirlari grilrliraa kgirtllfal mmslpalfni glllflvmfi
     1621 ysifgmasfa nvideagidd mfnfktfgns mlclfqitts agwdgllspi lntgppycdp
     1681 nrpnsngskg ncgspavgil ffttyiiisf livvnmyiav ilenfnvate esteplsedd
     1741 fdmfyetwek fdpeatqfia fsalsdfadt lsgplripkp nqniliqmdl plvpgdkihc
     1801 ldilfaftkn vlgesgelds lktnmeekfm atnlskasye piattlrckq edisatiiqk
     1861 ayrnymlqrs lmlsnplhvp raeedgvslp regyvtfman dngglpdkse tasatsfpps
     1921 ydsvtrglsd ranistsssm qnedevtake gkspgpq
//
LOCUS       NP_112455               1032 aa            linear   ROD 27-AUG-2025
DEFINITION  toll-like receptor 9 precursor [Mus musculus].
ACCESSION   NP_112455
VERSION     NP_112455.2
DBSOURCE    REFSEQ: accession NM_031178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1032)
  AUTHORS   Jayakumar,P., Jiang,T., Huang,H. and Deng,M.
  TITLE     An off-target effect of class A CpG-oligonucleotides on suppressing
            the cyclic GMP-AMP synthase signaling in fibroblastic reticular
            cells
  JOURNAL   Front Pharmacol 16, 1576151 (2025)
   PUBMED   40337520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1032)
  AUTHORS   Fan,R., Li,Q., Jiang,N., Zhang,Y., Yu,L., Zheng,Y., Su,Z.,
            Zhang,N., Chen,R., Feng,Y., Sang,X. and Chen,Q.
  TITLE     Plasmodium berghei TatD-like DNase hijacks host innate immunity by
            inhibiting the TLR9-NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 140, 112843 (2024)
   PUBMED   39098224
REFERENCE   3  (residues 1 to 1032)
  AUTHORS   Hatten,H., Colyn,L., Volkert,I., Gassler,N., Lammers,T.,
            Hofmann,U., Hengstler,J.G., Schneider,K.M. and Trautwein,C.
  TITLE     Loss of Toll-like receptor 9 protects from hepatocellular carcinoma
            in murine models of chronic liver disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167321 (2024)
   PUBMED   38943920
REFERENCE   4  (residues 1 to 1032)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1032)
  AUTHORS   Alippe,Y., Wang,L., Coskun,R., Muraro,S.P., Zhao,F.R.,
            Elam-Noll,M., White,J.M., Vota,D.M., Hauk,V.C., Gordon,J.I.,
            Handley,S.A. and Diamond,M.S.
  TITLE     Fetal MAVS and type I IFN signaling pathways control ZIKV infection
            in the placenta and maternal decidua
  JOURNAL   J Exp Med 221 (9) (2024)
   PUBMED   39042188
REFERENCE   6  (residues 1 to 1032)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   7  (residues 1 to 1032)
  AUTHORS   Chuang,T.H., Lee,J., Kline,L., Mathison,J.C. and Ulevitch,R.J.
  TITLE     Toll-like receptor 9 mediates CpG-DNA signaling
  JOURNAL   J Leukoc Biol 71 (3), 538-544 (2002)
   PUBMED   11867692
  REMARK    GeneRIF: TLR9 acts at the cell surface and engages an intracellular
            signaling pathway that includes MyD88, IRAK, and TRAF6
REFERENCE   8  (residues 1 to 1032)
  AUTHORS   Hemmi,H., Kaisho,T., Takeuchi,O., Sato,S., Sanjo,H., Hoshino,K.,
            Horiuchi,T., Tomizawa,H., Takeda,K. and Akira,S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
REFERENCE   9  (residues 1 to 1032)
  AUTHORS   Bauer,S., Kirschning,C.J., Hacker,H., Redecke,V., Hausmann,S.,
            Akira,S., Wagner,H. and Lipford,G.B.
  TITLE     Human TLR9 confers responsiveness to bacterial DNA via
            species-specific CpG motif recognition
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9237-9242 (2001)
   PUBMED   11470918
REFERENCE   10 (residues 1 to 1032)
  AUTHORS   Hemmi,H., Takeuchi,O., Kawai,T., Kaisho,T., Sato,S., Sanjo,H.,
            Matsumoto,M., Hoshino,K., Wagner,H., Takeda,K. and Akira,S.
  TITLE     A Toll-like receptor recognizes bacterial DNA
  JOURNAL   Nature 408 (6813), 740-745 (2000)
   PUBMED   11130078
  REMARK    Erratum:[Nature 2001 Feb 1;409(6820):646]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164430.3.
            
            On Sep 7, 2007 this sequence version replaced NP_112455.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045181.1, AF314224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     Protein         1..1032
                     /product="toll-like receptor 9 precursor"
                     /calculated_mol_wt=113659
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
                     /calculated_mol_wt=2772
     mat_peptide     26..1032
                     /product="Toll-like receptor 9. /id=PRO_0000034738"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
                     /calculated_mol_wt=113659
     Region          43..64
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          46..453
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          62..85
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          65..88
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..110
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          122..147
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          125..168
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            129
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          150..166
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          167..190
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          169..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          198..221
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          201..221
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            210
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF; propagated from UniProtKB/Swiss-Prot
                     (Q9EQU3.3)"
     Region          222..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          223..242
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            242
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          243..268
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          246..285
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          286..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          308..332
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            309
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          310..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            332
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPH; propagated
                     from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          333..356
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            340
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          363..386
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          390..413
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          393..411
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          415..440
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          430..462
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          471..495
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          <477..756
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          477..498
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            495
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          497..520
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          499..523
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            514
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          521..544
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          524..547
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          546..573
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          548..577
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            568
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          575..599
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          578..600
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          601..630
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          601..623
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          628..651
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          631..679
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          653..676
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            670
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          677..700
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          680..703
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            695
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            700
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          702..724
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          704..752
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          725..748
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            732
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPG,
                     ECO:0007744|PDB:3WPH, ECO:0007744|PDB:3WPI; propagated
                     from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          750..773
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            752
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          753..774
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            819..839
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          870..>974
                     /region_name="SEFIR"
                     /note="SEFIR domain; cl23749"
                     /db_xref="CDD:474043"
     CDS             1..1032
                     /gene="Tlr9"
                     /coded_by="NM_031178.2:107..3205"
                     /db_xref="CCDS:CCDS40755.1"
                     /db_xref="GeneID:81897"
                     /db_xref="MGI:MGI:1932389"
ORIGIN      
        1 mvlrrrtlhp lsllvqaavl aetlalgtlp aflpcelkph glvdcnwlfl ksvprfsaaa
       61 scsnitrlsl isnrihhlhn sdfvhlsnlr qlnlkwncpp tglsplhfsc hmtieprtfl
      121 amrtleelnl syngittvpr lpsslvnlsl shtnilvlda nslaglyslr vlfmdgncyy
      181 knpctgavkv tpgallglsn lthlslkynn ltkvprqlpp sleyllvsyn livklgpedl
      241 anltslrvld vggncrrcdh apnpciecgq kslhlhpetf hhlshleglv lkdsslhtln
      301 sswfqglvnl svldlsenfl yesithtnaf qnltrlrkln lsfnyrkkvs farlhlassf
      361 knlvslqeln mngiffrlln kytlrwladl pklhtlhlqm nfinqaqlsi fgtfralrfv
      421 dlsdnrisgp stlseatpee addaeqeell sadphpapls tpasknfmdr cknfkftmdl
      481 srnnlvtikp emfvnlsrlq clslshnsia qavngsqflp ltnlqvldls hnkldlyhwk
      541 sfselpqlqa ldlsynsqpf smkgighnfs fvthlsmlqs lslahndiht rvsshlnsns
      601 vrfldfsgng mgrmwdeggl ylhffqglsg llkldlsqnn lhilrpqnld nlpkslklls
      661 lrdnylsffn wtslsflpnl evldlagnql kaltngtlpn gtllqkldvs snsivsvvpa
      721 ffalavelke vnlshnilkt vdrswfgpiv mnltvldvrs nplhcacgaa fvdlllevqt
      781 kvpglangvk cgspgqlqgr sifaqdlrlc ldevlswdcf glsllavavg mvvpilhhlc
      841 gwdvwycfhl clawlpllar srrsaqtlpy dafvvfdkaq savadwvyne lrvrleerrg
      901 rralrlcled rdwlpgqtlf enlwasiygs rktlfvlaht drvsgllrts fllaqqrlle
      961 drkdvvvlvi lrpdahrsry vrlrqrlcrq svlfwpqqpn gqggfwaqls taltrdnrhf
     1021 ynqnfcrgpt ae
//
LOCUS       NP_001395634            1932 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
            [Mus musculus].
ACCESSION   NP_001395634
VERSION     NP_001395634.1
DBSOURCE    REFSEQ: accession NM_001408705.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1932)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1932)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1932)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 1932)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 1932)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 1932)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 1932)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 1932)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 1932)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 1932)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.13353.1,
                                           SRR10223969.12740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..1932
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 4"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=214802
     Region          49..164
                     /region_name="PWWP_NSD1_rpt1"
                     /note="first PWWP domain found in nuclear receptor-binding
                     SET domain-containing protein 1 (NSD1) and similar
                     proteins; cd20161"
                     /db_xref="CDD:438989"
     Site            order(65,68,99)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438989"
     Site            66..69
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438989"
     Site            order(137..139,142..143)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438989"
     Region          <1183..1317
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          1276..1317
                     /region_name="PHD1_NSD1_2"
                     /note="PHD finger 1 found in nuclear receptor-binding SET
                     domain-containing protein NSD1 and NSD2; cd15648"
                     /db_xref="CDD:277118"
     Site            order(1276,1285..1289,1294,1312)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277118"
     Region          1323..1369
                     /region_name="PHD2_NSD1"
                     /note="PHD finger 2 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15650"
                     /db_xref="CDD:277120"
     Site            order(1323,1333..1337,1343,1364)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277120"
     Region          1370..1423
                     /region_name="PHD3_NSD1"
                     /note="PHD finger 3 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15653"
                     /db_xref="CDD:277123"
     Site            order(1370,1388..1392,1396,1418)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277123"
     Region          1440..1479
                     /region_name="PHD4_NSD1"
                     /note="PHD finger 4 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15656"
                     /db_xref="CDD:277126"
     Site            order(1440,1449..1453,1457,1474)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277126"
     Region          1486..1581
                     /region_name="PWWP_NSD1_rpt2"
                     /note="second PWWP domain found in nuclear
                     receptor-binding SET domain-containing protein 1 (NSD1)
                     and similar proteins; cd20164"
                     /db_xref="CDD:438992"
     Site            order(1498,1501,1529)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438992"
     Site            1499..1502
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438992"
     Region          1632..1670
                     /region_name="AWS"
                     /note="AWS domain; pfam17907"
                     /db_xref="CDD:465559"
     Region          1672..1813
                     /region_name="SET_NSD1"
                     /note="SET domain (including post-SET domain) found in
                     nuclear receptor-binding SET domain-containing protein 1
                     (NSD1) and similar proteins; cd19210"
                     /db_xref="CDD:380987"
     Site            order(1683..1685,1702,1712,1716,1725..1731,1748..1752,
                     1759..1761,1776,1787..1797,1799..1803,1812)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380987"
     Site            order(1683..1685,1725..1728,1748..1752,1789,1796,
                     1800..1803,1812)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380987"
     Site            order(1702,1712,1716,1727..1731,1759..1761,1776,
                     1787..1791)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:380987"
     Site            order(1754,1801,1803,1808)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:380987"
     Region          1851..1886
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1851,1861..1864,1870)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277129"
     CDS             1..1932
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408705.1:395..6193"
                     /note="isoform 4 is encoded by transcript variant 9"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mppktrtals ddpdsspspl gnmleipgts spstsqelpf cqpkkkstpl kyevgdliwa
       61 kfkrrpwwpc ricsdplint hskmkvanrr pyreyyveaf gdpsekawva gkaivmfegr
      121 hqfeelpvlr krgkqkekgy rhkvpqkils kweasvglae qydvpkgskn qkcvsssvkl
      181 dseedmpfed ctndpdsehl llngclksla fdsehsadek ekpcaksrvr kssdnikrts
      241 vkkdlvpfes rkeerrgkip dnlgldfisg gvsdkqasne lsriansltg sstapgsflf
      301 sssvqntakt dfetpdcdsl sglsesalis khsgekkklq pgqvcsskvq lcyvgagdee
      361 krsnsvsvst tsddgcsdld ptehnsgfqn svlgitdafd ktenalsvhk netqysrypv
      421 tnrikekqks litnshadhl mgstktmepe taelsqvnls dlkisspipk pqpefrndgl
      481 ttkfsappgi rnenpltkgg lanqtllplk crqpkfrsik ckhkespava etsatsedls
      541 lkccssdtng splanisksg kgeglkllnn mhektrdssd ietavvkhvl selkelsyrs
      601 lsedvsdsgt akaskpllfs sassqnhipi epdykfstll mmlkdmhdsk tkeqrlmtaq
      661 nlasyrtpdr gdcssgspvg tskvlvlgss tpnsekpgds tqdsvhqspg ggdsalsgel
      721 ssslsslasd krelpacgki rsnciprrnc grakpssklr etisaqmvkp svnpkalkte
      781 rkrkfsrlpa vtlaanrlgn kesgsvngps rggaedpgke eplqqmdllr nedthfsdvh
      841 fdskakqsdp dknlekepsf enrkgpelgs emntendelh gvnqvvpkkr wqrlnqrrpk
      901 pgkranrfre kensegafgv llpadavqka redyleqrap ptskpedsaa dpnhgshses
      961 vaprlnvcek ssvgmgdvek etgipslmpq tklpepairs ekkrlrkpsk wlleyteeyd
     1021 qifapkkkqk kvqeqvhkvs srcedeslla rcqpsaqnkq vdenslistk eeppvlerea
     1081 pflegplaqs dlgvthaelp qltlsvpvap easprpales eellvktpgn yeskrqrkpt
     1141 kkllesndld pgfmpkkgdl glsrkcfeas rsgngivesr atshlkefsg gttkifdkpr
     1201 krkrqrlvta rvhykkvkke dltkdtpsse gellihrtaa spkeileegv ehdpgmsask
     1261 klqverggga alkenvcqnc eklgelllce aqccgafhle clglpemprg kficnechtg
     1321 ihtcfvckqs gedvkrcllp lcgkfyheec vqkypptvtq nkgfrcplhi citchaanpa
     1381 nvsaskgrlm rcvrcpvayh andfclaags kilasnsiic pnhftprrgc rnhehvnvsw
     1441 cfvcseggsl lccdscpaaf hreclnidip egnwycndck agkkphyrei vwvkvgryrw
     1501 wpaeichpra vpsnidkmrh dvgefpvlff gsndylwthq arvfpymegd vsskdkmgkg
     1561 vdgtykkalq eaaarfeelk aqkelrqlqe drkndkkppp ykhikvnrpi grvqiftadl
     1621 seiprcncka tdenpcgids ecinrmllye chptvcpagv rcqnqcfskr qypdveifrt
     1681 lqrgwglrtk tdikkgefvn eyvgelidee ecrariryaq ehditnfyml tldkdriida
     1741 gpkgnyarfm nhccqpncet qkwsvngdtr vglfalsdik agteltfnyn leclgngktv
     1801 ckcgapncsg flgvrpknqp ivteeksrkf krkphgkrrs qgevtkered ecfscgdagq
     1861 lvsckkpgcp kvyhadclnl tkrpagwcfs pfralllyqg fqnlmpatcv tqkahavckh
     1921 vptlrallhi li
//
LOCUS       NP_001389916             810 aa            linear   ROD 27-AUG-2025
DEFINITION  peroxisome proliferator-activated receptor gamma coactivator
            1-alpha isoform b [Mus musculus].
ACCESSION   NP_001389916 XP_006503837
VERSION     NP_001389916.1
DBSOURCE    REFSEQ: accession NM_001402987.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 810)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 810)
  AUTHORS   Cai,J.X., Le,A.W., Han,X.Y., Chen,J., Lei,X.H., Huang,C. and
            Zhang,J.V.
  TITLE     Chemerin sustains the growth of spongiotrophoblast and sinusoidal
            trophoblast giant cells through fatty acid oxidation
  JOURNAL   BMC Biol 23 (1), 199 (2025)
   PUBMED   40611253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 810)
  AUTHORS   Shi,H., Li,J., Li,F., Yu,H., Zhang,F., Wu,T., Yang,L., Li,Y.,
            Hu,R., Chen,M., Sg,N., Zhuang,X., Feng,S., Zhu,L. and Duan,R.
  TITLE     Vitamin C-Dependent Intergenerational Inheritance of Enhanced
            Endurance Performance Following Maternal Exercise
  JOURNAL   Adv Sci (Weinh) 12 (13), e2408912 (2025)
   PUBMED   39921869
REFERENCE   4  (residues 1 to 810)
  AUTHORS   Dumesic,P.A., Wilensky,S.E., Bose,S., Van Vranken,J.G., Gygi,S.P.
            and Spiegelman,B.M.
  TITLE     RBM43 controls PGC1alpha translation and a PGC1alpha-STING
            signaling axis
  JOURNAL   Cell Metab 37 (3), 742-757 (2025)
   PUBMED   39965564
REFERENCE   5  (residues 1 to 810)
  AUTHORS   Wang,Y., Li,X., Liu,C., Zhou,L., Shi,L., Zhang,Z., Chen,L., Gao,M.,
            Gao,L., Xu,Y., Huang,H., Li,J. and Chen,Z.
  TITLE     WTAP regulates postnatal development of brown adipose tissue by
            stabilizing METTL3 in mice
  JOURNAL   Life Metab 1 (3), 270-284 (2022)
   PUBMED   39872074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 810)
  AUTHORS   Kakuma,T., Wang,Z.W., Pan,W., Unger,R.H. and Zhou,Y.T.
  TITLE     Role of leptin in peroxisome proliferator-activated receptor gamma
            coactivator-1 expression
  JOURNAL   Endocrinology 141 (12), 4576-4582 (2000)
   PUBMED   11108270
REFERENCE   7  (residues 1 to 810)
  AUTHORS   Lehman,J.J., Barger,P.M., Kovacs,A., Saffitz,J.E., Medeiros,D.M.
            and Kelly,D.P.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator-1
            promotes cardiac mitochondrial biogenesis
  JOURNAL   J Clin Invest 106 (7), 847-856 (2000)
   PUBMED   11018072
REFERENCE   8  (residues 1 to 810)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   9  (residues 1 to 810)
  AUTHORS   Boss,O., Bachman,E., Vidal-Puig,A., Zhang,C.Y., Peroni,O. and
            Lowell,B.B.
  TITLE     Role of the beta(3)-adrenergic receptor and/or a putative
            beta(4)-adrenergic receptor on the expression of uncoupling
            proteins and peroxisome proliferator-activated receptor-gamma
            coactivator-1
  JOURNAL   Biochem Biophys Res Commun 261 (3), 870-876 (1999)
   PUBMED   10441518
REFERENCE   10 (residues 1 to 810)
  AUTHORS   Puigserver,P., Wu,Z., Park,C.W., Graves,R., Wright,M. and
            Spiegelman,B.M.
  TITLE     A cold-inducible coactivator of nuclear receptors linked to
            adaptive thermogenesis
  JOURNAL   Cell 92 (6), 829-839 (1998)
   PUBMED   9529258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC111037.8 and AC116763.11.
            
            On Mar 24, 2022 this sequence version replaced XP_006503837.1.
            
            Summary: This gene encodes a transcriptional coactivator that
            induces and coordinates gene expression regulating mitochondrial
            biogenesis, respiration, hepatic gluconeogenesis, thermogenic
            program in brown fat and muscle fiber-type switching. Mice lacking
            the encoded protein exhibit reduced thermogenic capacity,
            hyperactivity and resistance to diet-induced obesity. Mice lacking
            the encoded protein specifically in the heart exhibit peripartum
            cardiomyopathy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.159649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 27.02 cM"
     Protein         1..810
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha isoform b"
                     /note="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha; PPAR-gamma coactivator 1-alpha"
                     /calculated_mol_wt=91780
     Region          687..777
                     /region_name="RRM_PPARGC1A"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator 1-alpha
                     (PGC-1alpha, or PPARGC-1-alpha) and similar proteins;
                     cd12623"
                     /db_xref="CDD:410034"
     CDS             1..810
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /coded_by="NM_001402987.1:505..2937"
                     /note="isoform b is encoded by transcript variant 4"
                     /db_xref="GeneID:19017"
                     /db_xref="MGI:MGI:1342774"
ORIGIN      
        1 magcglsedt flssffynyg sswetpsnqc aalvgedqpl cpdlpeldls eldvndldtd
       61 sflgglkwcs dqseiisnqy nnepanifek ideeneanll avltetldsl pvdedglpsf
      121 daltdgavtt dneaspssmp dgtpppqeae epsllkklll apantqlsyn ecsglstqnh
      181 aanhthrirt npaivktens wsnkaksicq qqkpqrrpcs ellkylttnd dpphtkpten
      241 rnssrdkcas kkkshtqpqs qhaqakpttl slpltpespn dpkgspfenk tiertlsvel
      301 sgtagltppt tpphkanqdn pfkaspklkp scktvvpppt krarysecsg tqgshstkkg
      361 peqselyaql skssglsrgh eerktkrpsl rlfgdhdycq slnsktdili nisqelqdsr
      421 qldfkdascd wqghicsstd sgqcylretl easkqvspcs trkqlqdqei raelnkhfgh
      481 pcqavfddks dktselrdgd fsneqfsklp vfinsglamd glfddsedes dklsypwdgt
      541 qpyslfdvsp scssfnspcr dsvsppkslf sqrpqrmrsr srsfsrhrsc srspysrsrs
      601 rspgsrsssr scyyyesshy rhrthrnspl yvrsrsrspy srrprydsye ayeherlkrd
      661 eyrkehekre serakqrerq kqkaieerrv iyvgkirpdt trtelrdrfe vfgeieectv
      721 nlrddgdsyg fityrytcda faalengytl rrsnetdfel yfcgrkqffk snyadldtns
      781 ddfdpastks kydsldfdsl lkeaqrslrr
//
LOCUS       NP_001299797             499 aa            linear   ROD 27-AUG-2025
DEFINITION  TGF-beta receptor type-1 isoform 2 precursor [Mus musculus].
ACCESSION   NP_001299797 XP_006537819
VERSION     NP_001299797.1
DBSOURCE    REFSEQ: accession NM_001312868.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 499)
  AUTHORS   Ware,K., Peter,J., McClain,L. and Luo,Y.
  TITLE     Cell type-dependent role of transforming growth factor-beta
            signaling on postnatal neural stem cell proliferation and migration
  JOURNAL   Neural Regen Res 21 (3), 1151-1161 (2026)
   PUBMED   39885664
REFERENCE   2  (residues 1 to 499)
  AUTHORS   Tang,Q., Li,L., Li,Y., Wang,A., Li,H., Wang,L., Gu,C., Lee,J.M.,
            Wu,Z., Kwon,H.E. and Chen,Y.
  TITLE     Distinct BMP-Smad signaling outputs confer diverse functions in
            dental mesenchyme
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40446216
REFERENCE   3  (residues 1 to 499)
  AUTHORS   Sugimoto,A., Saito,Y., Wang,G., Sun,Q., Yin,C., Lee,K.H., Geng,Y.,
            Rajbhandari,P., Hernandez,C., Steffani,M., Qie,J., Savage,T.,
            Goyal,D.M., Ray,K.C., Neelakantan,T.V., Yin,D., Melms,J.,
            Lehrich,B.M., Yasaka,T.M., Liu,S., Oertel,M., Lan,T., Guillot,A.,
            Peiseler,M., Filliol,A., Kanzaki,H., Fujiwara,N., Ravi,S., Izar,B.,
            Brosch,M., Hampe,J., Remotti,H., Argemi,J., Sun,Z., Kendall,T.J.,
            Hoshida,Y., Tacke,F., Fallowfield,J.A., Blockley-Powell,S.K.,
            Haeusler,R.A., Steinman,J.B., Pajvani,U.B., Monga,S.P.,
            Bataller,R., Masoodi,M., Arpaia,N., Lee,Y.A., Stockwell,B.R.,
            Augustin,H.G. and Schwabe,R.F.
  TITLE     Hepatic stellate cells control liver zonation, size and functions
            via R-spondin 3
  JOURNAL   Nature 640 (8059), 752-761 (2025)
   PUBMED   40074890
REFERENCE   4  (residues 1 to 499)
  AUTHORS   Wang,X., Zhao,X., Zheng,X., Peng,X., Chen,J., Wang,Y., Wang,Z.,
            Meng,M. and Du,J.
  TITLE     Sirt6 loss activates Got1 and facilitates cleft palate through
            abnormal activating glycolysis
  JOURNAL   Cell Death Dis 16 (1), 159 (2025)
   PUBMED   40050262
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 499)
  AUTHORS   Lozovska,A., Casaca,A., Novoa,A., Kuo,Y.Y., Jurberg,A.D.,
            Martins,G.G., Hadjantonakis,A.K. and Mallo,M.
  TITLE     Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization
            during the trunk to tail transition
  JOURNAL   Elife 13, 94290 (2025)
   PUBMED   39874182
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 499)
  AUTHORS   Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H.,
            Ohtani,H., Hayashi,Y. and Eto,K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (residues 1 to 499)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (residues 1 to 499)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (residues 1 to 499)
  AUTHORS   Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (residues 1 to 499)
  AUTHORS   Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772232.18 and AL772150.11.
            
            On Aug 19, 2015 this sequence version replaced XP_006537819.1.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3676856.1,
                                           SRR9219381.91597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     Protein         1..499
                     /product="TGF-beta receptor type-1 isoform 2 precursor"
                     /EC_number="2.7.11.30"
                     /note="TGF-beta receptor type-1; TGF-beta receptor type I;
                     transforming growth factor-beta receptor type I"
                     /calculated_mol_wt=52924
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2885
     Region          30..104
                     /region_name="TFP_LU_ECD_ALK5"
                     /note="extracellular domain (ECD) found in activin
                     receptor-like kinase 5 (ALK-5) and similar proteins;
                     cd23537"
                     /db_xref="CDD:467067"
     Site            41
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Site            123..143
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64729.1)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Region          172..199
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:462503"
     Site            181
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by TGFBR2.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by TGFBR2.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Site            183
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TGFBR2.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TGFBR2.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TGFBR2.
                     /evidence=ECO:0000250|UniProtKB:P36897; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Region          189..190
                     /region_name="FKBP1A-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64729.1)"
     Region          205..492
                     /region_name="STKc_TGFbR1_ACVR1b_ACVR1c"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Transforming Growth Factor beta Type I Receptor and
                     Activin Type IB/IC Receptors; cd14143"
                     /db_xref="CDD:271045"
     Site            order(207..211,215,226,228,256,276..279,283,285,329,331,
                     333..334,336,347,350,370..373)
                     /site_type="active"
                     /db_xref="CDD:271045"
     Site            order(207..213,215,226,228,276..277,279,283,333..334,336,
                     347)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271045"
     Site            order(211,283,285,329,331,333,350,370..373)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271045"
     Site            order(238..239,242..243,246..247,261,263)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271045"
     Site            346..373
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271045"
     CDS             1..499
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /coded_by="NM_001312868.2:55..1554"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS84728.1"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
ORIGIN      
        1 meaaaaaprr pqllivlvaa atllpgakal qcfchlctkd nftcetdglc fvsvtettdk
       61 vihnsmciae idliprdrpf vcapssktga vtttyccnqd hcnkielptt ekqsaglgpv
      121 elaaviagpv cfvcialmlm vyichnrtvi hhrvpneedp sldrpfiseg ttlkdliydm
      181 ttsgsgsglp llvqrtiart ivlqesigkg rfgevwrgkw rgeevavkif ssreerswfr
      241 eaeiyqtvml rhenilgfia adnkdngtwt qlwlvsdyhe hgslfdylnr ytvtvegmik
      301 lalstasgla hlhmeivgtq gkpaiahrdl ksknilvkkn gtcciadlgl avrhdsatdt
      361 idiapnhrvg tkrymapevl ddsinmkhfe sfkradiyam glvfweiarr csiggihedy
      421 qlpyydlvps dpsveemrkv vceqklrpni pnrwqsceal rvmakimrec wyangaarlt
      481 alrikktlsq lsqqegikm
//
LOCUS       NP_031978                505 aa            linear   ROD 27-AUG-2025
DEFINITION  protein disulfide-isomerase A3 precursor [Mus musculus].
ACCESSION   NP_031978
VERSION     NP_031978.2
DBSOURCE    REFSEQ: accession NM_007952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 505)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 505)
  AUTHORS   Luo,J.H., Wang,F.X., Zhao,J.W., Yang,C.L., Rong,S.J., Lu,W.Y.,
            Chen,Q.J., Zhou,Q., Xiao,J., Wang,Y.N., Luo,X., Li,Y., Song,D.N.,
            Chen,C., Zhang,C.L., Chen,S.H., Yang,P., Xiong,F., Yu,Q.L.,
            Zhang,S., Liu,S.W., Sun,F. and Wang,C.Y.
  TITLE     PDIA3 defines a novel subset of adipose macrophages to exacerbate
            the development of obesity and metabolic disorders
  JOURNAL   Cell Metab 36 (10), 2262-2280 (2024)
   PUBMED   39293433
  REMARK    GeneRIF: PDIA3 defines a novel subset of adipose macrophages to
            exacerbate the development of obesity and metabolic disorders.
REFERENCE   3  (residues 1 to 505)
  AUTHORS   Liu,H., Zheng,Y., Li,F., Geng,B. and Liao,F.
  TITLE     Endoplasmic reticulum protein of 57 kDa sulfhydration promotes
            intestinal calcium absorption to attenuate primary osteoporosis
  JOURNAL   Nitric Oxide 149, 32-40 (2024)
   PUBMED   38830571
  REMARK    GeneRIF: Endoplasmic reticulum protein of 57 kDa sulfhydration
            promotes intestinal calcium absorption to attenuate primary
            osteoporosis.
REFERENCE   4  (residues 1 to 505)
  AUTHORS   Czyzynska-Cichon,I., Giergiel,M., Kwiatkowski,G., Kurpinska,A.,
            Wojnar-Lason,K., Kaczara,P., Szymonski,M., Lekka,M., Kalvins,I.,
            Zapotoczny,B. and Chlopicki,S.
  TITLE     Protein disulfide isomerase A1 regulates fenestration dynamics in
            primary mouse liver sinusoidal endothelial cells (LSECs)
  JOURNAL   Redox Biol 72, 103162 (2024)
   PUBMED   38669864
  REMARK    GeneRIF: Protein disulfide isomerase A1 regulates fenestration
            dynamics in primary mouse liver sinusoidal endothelial cells
            (LSECs).
REFERENCE   5  (residues 1 to 505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 505)
  AUTHORS   Merrick,B.A., Patterson,R.M., Witcher,L.L., He,C. and Selkirk,J.K.
  TITLE     Separation and sequencing of familiar and novel murine proteins
            using preparative two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 15 (5), 735-745 (1994)
   PUBMED   7523108
REFERENCE   7  (residues 1 to 505)
  AUTHORS   Burglin,T.R. and Barnes,T.M.
  TITLE     Introns in sequence tags
  JOURNAL   Nature 357 (6377), 367-368 (1992)
   PUBMED   1350660
REFERENCE   8  (residues 1 to 505)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
REFERENCE   9  (residues 1 to 505)
  AUTHORS   Melero,J.A. and Smith,A.E.
  TITLE     Possible transcriptional control of three polypeptides which
            accumulate in a temperature-sensitive mammalian cell line
  JOURNAL   Nature 272 (5655), 725-727 (1978)
   PUBMED   643066
REFERENCE   10 (residues 1 to 505)
  AUTHORS   Kirby,G.C.
  TITLE     The genetics of an electrophoretic variant of an erythrocytic
            protein in the house mouse (Mus musculus)
  JOURNAL   Anim Blood Groups Biochem Genet 5 (3), 153-157 (1974)
   PUBMED   4451294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ714617.1, AK133799.1, AK132459.1, AL845466.4 and BQ033063.1.
            
            On Aug 15, 2006 this sequence version replaced NP_031978.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132459.1, SRR1660815.40212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.38 cM"
     Protein         1..505
                     /product="protein disulfide-isomerase A3 precursor"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase A3; p58; 58 kDa
                     microsomal protein; disulfide isomerase ER-60; ER protein
                     57; ER protein 60; 58 kDa glucose-regulated protein;
                     endoplasmic reticulum resident protein 57; endoplasmic
                     reticulum resident protein 60; endoplasmic reticulum
                     protein; glucose regulated protein, 58 kDa; phospholipase
                     C, alpha"
                     /calculated_mol_wt=54268
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2429
     mat_peptide     25..505
                     /product="Protein disulfide-isomerase A3.
                     /id=PRO_0000034226"
                     /note="propagated from UniProtKB/Swiss-Prot (P27773.2)"
                     /calculated_mol_wt=54268
     Region          26..487
                     /region_name="ER_PDI_fam"
                     /note="protein disulfide isomerase, eukaryotic; TIGR01130"
                     /db_xref="CDD:273457"
     Site            58
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            59
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            61
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P30101; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            119
                     /site_type="other"
                     /note="Lowers pKa of C-terminal Cys of first active site.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            152
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            252
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P30101; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            362
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            407
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            408
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Site            471
                     /site_type="other"
                     /note="Lowers pKa of C-terminal Cys of second active site.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Region          484..505
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27773.2)"
     Site            494
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27773.2)"
     Region          502..505
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000250|UniProtKB:P11598"
                     /note="propagated from UniProtKB/Swiss-Prot (P27773.2)"
     CDS             1..505
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /coded_by="NM_007952.2:138..1655"
                     /db_xref="CCDS:CCDS16643.1"
                     /db_xref="GeneID:14827"
                     /db_xref="MGI:MGI:95834"
ORIGIN      
        1 mrfsclallp gvalllasar laaasdvlel tdenfesrvs dtgsaglmlv effapwcghc
       61 krlapeyeaa atrlkgivpl akvdctantn tcnkygvsgy ptlkifrdge eagaydgprt
      121 adgivshlkk qagpasvplr teeefkkfis dkdasvvgff rdlfsdghse flkaasnlrd
      181 nyrfahtnie slvkeyddng egitifrplh lankfedktv aytekkmtsg kikkfiqdsi
      241 fglcphmted nkdliqgkdl ltayydvdye knakgsnywr nrvmmvakkf ldaghklnfa
      301 vasrktfshe lsdfglestt gevpvvairt akgekfvmqe efsrdgkale qflqeyfdgn
      361 lkrylksepi pesnegpvkv vvaenfddiv needkdvlie fyapwcghck nlepkykelg
      421 eklskdpniv iakmdatand vpspyevkgf ptiyfspank kltpkkyegg relndfisyl
      481 qreatnppii qeekpkkkkk aqedl
//
LOCUS       NP_038702                450 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon regulatory factor 4 isoform a [Mus musculus].
ACCESSION   NP_038702
VERSION     NP_038702.1
DBSOURCE    REFSEQ: accession NM_013674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 450)
  AUTHORS   Tadepalli,S., Clements,D.R., Raquer-McKay,H.M., Ludtke,A.,
            Saravanan,S., Seong,D., Vitek,L., Richards,C.M., Carette,J.E.,
            Mack,M., Gottfried-Blackmore,A., Graves,E.E. and Idoyaga,J.
  TITLE     CD301b+ monocyte-derived dendritic cells mediate resistance to
            radiotherapy
  JOURNAL   J Exp Med 222 (6) (2025)
   PUBMED   40146036
REFERENCE   2  (residues 1 to 450)
  AUTHORS   Gao,X., Shen,X., Xu,Q., Zeng,Y., Dong,L., Hong,S., Jin,H., Wang,Q.,
            Wang,D., Lu,L. and Wang,L.
  TITLE     The transcription factor IRF4 regulates the homeostasis and
            function of intestinal ILC3s
  JOURNAL   iScience 28 (7), 112800 (2025)
   PUBMED   40585371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 450)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 450)
  AUTHORS   Gabele,A., Sprang,M., Cihan,M., Welzel,M., Nurbekova,A.,
            Romaniuk,K., Dietzen,S., Klein,M., Bundgen,G., Emelianov,M.,
            Harms,G., Rajalingam,K., Ziesmann,T., Pape,K., Wasser,B.,
            Gomez-Zepeda,D., Braband,K., Delacher,M., Lemmermann,N.,
            Bittner,S., Andrade-Navarro,M.A., Tenzer,S., Luck,K., Bopp,T. and
            Distler,U.
  TITLE     Unveiling IRF4-steered regulation of context-dependent effector
            programs in CD4+ T cells under Th17- and Treg-skewing conditions
  JOURNAL   Cell Rep 44 (3), 115407 (2025)
   PUBMED   40067830
REFERENCE   5  (residues 1 to 450)
  AUTHORS   Zhou,L., Lin,P., Deng,G., Mo,L., Hong,C., Jiang,Z., Zhu,Y.,
            Zhao,Y., Qi,Y., Hu,T., Wu,Q., Zhang,J., Li,Q. and Yang,Q.
  TITLE     IRF4 regulates myeloid-derived suppressor cells expansion and
            function in Schistosoma japonicum-infected mice
  JOURNAL   Parasit Vectors 17 (1), 492 (2024)
   PUBMED   39609883
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 450)
  AUTHORS   Mittrucker,H.W., Matsuyama,T., Grossman,A., Kundig,T.M., Potter,J.,
            Shahinian,A., Wakeham,A., Patterson,B., Ohashi,P.S. and Mak,T.W.
  TITLE     Requirement for the transcription factor LSIRF/IRF4 for mature B
            and T lymphocyte function
  JOURNAL   Science 275 (5299), 540-543 (1997)
   PUBMED   8999800
REFERENCE   7  (residues 1 to 450)
  AUTHORS   Grossman,A., Mittrucker,H.W., Nicholl,J., Suzuki,A., Chung,S.,
            Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P. and Mak,T.W.
  TITLE     Cloning of human lymphocyte-specific interferon regulatory factor
            (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
  JOURNAL   Genomics 37 (2), 229-233 (1996)
   PUBMED   8921401
REFERENCE   8  (residues 1 to 450)
  AUTHORS   Henkel,G.W., McKercher,S.R., Yamamoto,H., Anderson,K.L.,
            Oshima,R.G. and Maki,R.A.
  TITLE     PU.1 but not ets-2 is essential for macrophage development from
            embryonic stem cells
  JOURNAL   Blood 88 (8), 2917-2926 (1996)
   PUBMED   8874188
REFERENCE   9  (residues 1 to 450)
  AUTHORS   Matsuyama,T., Grossman,A., Mittrucker,H.W., Siderovski,D.P.,
            Kiefer,F., Kawakami,T., Richardson,C.D., Taniguchi,T.,
            Yoshinaga,S.K. and Mak,T.W.
  TITLE     Molecular cloning of LSIRF, a lymphoid-specific member of the
            interferon regulatory factor family that binds the
            interferon-stimulated response element (ISRE)
  JOURNAL   Nucleic Acids Res 23 (12), 2127-2136 (1995)
   PUBMED   7541907
REFERENCE   10 (residues 1 to 450)
  AUTHORS   Eisenbeis,C.F., Singh,H. and Storb,U.
  TITLE     Pip, a novel IRF family member, is a lymphoid-specific,
            PU.1-dependent transcriptional activator
  JOURNAL   Genes Dev 9 (11), 1377-1387 (1995)
   PUBMED   7797077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645745.7 and BC137714.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11692.1, AK154315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.28 cM"
     Protein         1..450
                     /product="interferon regulatory factor 4 isoform a"
                     /note="PU.1 interaction partner; transcriptional activator
                     PIP; lymphocyte-specific interferon regulatory factor;
                     Sfpi1/PU.1 interaction partner"
                     /calculated_mol_wt=51446
     Region          23..128
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(56,96,98..99,102)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            order(101..102,104,107)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          249..418
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:463076"
     Site            446
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK2.
                     /evidence=ECO:0000269|PubMed:20697158; propagated from
                     UniProtKB/Swiss-Prot (Q64287.1)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK2.
                     /evidence=ECO:0000269|PubMed:20697158; propagated from
                     UniProtKB/Swiss-Prot (Q64287.1)"
     CDS             1..450
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /coded_by="NM_013674.2:96..1448"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26419.1"
                     /db_xref="GeneID:16364"
                     /db_xref="MGI:MGI:1096873"
ORIGIN      
        1 mnletgsrgs efgmsavscg ngklrqwlid qidsgkypgl vweneeksvf ripwkhagkq
       61 dynreedaal fkawalfkgk fregidkpdp ptwktrlrca lnksndfeel versqldisd
      121 pykvyrivpe gakkgakqlt lddtqmamgh pypmtapygs lpaqqvhnym mpphdrswrd
      181 yapdqshpei pyqcpvtfgp rghhwqgpsc engcqvtgtf yacappesqa pgipiepsir
      241 saealalsdc rlhiclyyrd ilvkelttts pegcrishgh tydvsnldqv lfpypddngq
      301 rkniekllsh lerglvlwma pdglyakrlc qsriywdgpl alcsdrpnkl erdqtcklfd
      361 tqqflselqv fahhgrpapr fqvtlcfgee fpdpqrqrkl itahveplla rqlyyfaqqn
      421 tghflrgyel pehvttpdyh rslrhssiqe
//
LOCUS       NP_034678                178 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-10 precursor [Mus musculus].
ACCESSION   NP_034678
VERSION     NP_034678.1
DBSOURCE    REFSEQ: accession NM_010548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 178)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 178)
  AUTHORS   Zhou,W., Zhou,J.Z., Ahmed,A., Kim,M.J., Guo,C.J. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     ILC3s sense gut microbiota through STING to initiate immune
            tolerance
  JOURNAL   Immunity 58 (7), 1762-1777 (2025)
   PUBMED   40527323
REFERENCE   3  (residues 1 to 178)
  AUTHORS   Brown,E.M., Temple,E.R., Jeanfavre,S., Avila-Pacheco,J., Taylor,N.,
            Liu,K., Nguyen,P.N.U., Mohamed,A.M.T., Ung,P., Walker,R.A.,
            Graham,D.B., Clish,C.B. and Xavier,R.J.
  TITLE     Bacteroides sphingolipids promote anti-inflammatory responses
            through the mevalonate pathway
  JOURNAL   Cell Host Microbe 33 (6), 901-914 (2025)
   PUBMED   40449488
REFERENCE   4  (residues 1 to 178)
  AUTHORS   Saraiva,M., Christensen,J.R., Tsytsykova,A.V., Goldfeld,A.E.,
            Ley,S.C., Kioussis,D. and O'Garra,A.
  TITLE     Identification of a macrophage-specific chromatin signature in the
            IL-10 locus
  JOURNAL   J Immunol 175 (2), 1041-1046 (2005)
   PUBMED   16002704
  REMARK    GeneRIF: Production of IL-10 by primary mouse bone marrow-derived
            macrophages stimulated through pattern recognition receptors is
            associated with chromatin remodeling of the IL-10 locus.
REFERENCE   5  (residues 1 to 178)
  AUTHORS   Ghildyal,N., McNeil,H.P., Stechschulte,S., Austen,K.F.,
            Silberstein,D., Gurish,M.F., Somerville,L.L. and Stevens,R.L.
  TITLE     IL-10 induces transcription of the gene for mouse mast cell
            protease-1, a serine protease preferentially expressed in mucosal
            mast cells of Trichinella spiralis-infected mice
  JOURNAL   J Immunol 149 (6), 2123-2129 (1992)
   PUBMED   1517575
REFERENCE   6  (residues 1 to 178)
  AUTHORS   Kim,J.M., Brannan,C.I., Copeland,N.G., Jenkins,N.A., Khan,T.A. and
            Moore,K.W.
  TITLE     Structure of the mouse IL-10 gene and chromosomal localization of
            the mouse and human genes
  JOURNAL   J Immunol 148 (11), 3618-3623 (1992)
   PUBMED   1350294
REFERENCE   7  (residues 1 to 178)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   8  (residues 1 to 178)
  AUTHORS   Vieira,P., de Waal-Malefyt,R., Dang,M.N., Johnson,K.E.,
            Kastelein,R., Fiorentino,D.F., deVries,J.E., Roncarolo,M.G.,
            Mosmann,T.R. and Moore,K.W.
  TITLE     Isolation and expression of human cytokine synthesis inhibitory
            factor cDNA clones: homology to Epstein-Barr virus open reading
            frame BCRFI
  JOURNAL   Proc Natl Acad Sci U S A 88 (4), 1172-1176 (1991)
   PUBMED   1847510
REFERENCE   9  (residues 1 to 178)
  AUTHORS   Moore,K.W., Vieira,P., Fiorentino,D.F., Trounstine,M.L., Khan,T.A.
            and Mosmann,T.R.
  TITLE     Homology of cytokine synthesis inhibitory factor (IL-10) to the
            Epstein-Barr virus gene BCRFI
  JOURNAL   Science 248 (4960), 1230-1234 (1990)
   PUBMED   2161559
  REMARK    Erratum:[Science 1990 Oct 26;250(4980):494]
REFERENCE   10 (residues 1 to 178)
  AUTHORS   Fiorentino,D.F., Bond,M.W. and Mosmann,T.R.
  TITLE     Two types of mouse T helper cell. IV. Th2 clones secrete a factor
            that inhibits cytokine production by Th1 clones
  JOURNAL   J Exp Med 170 (6), 2081-2095 (1989)
   PUBMED   2531194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK152344.1 and AL513351.26.
            
            Summary: This gene encodes an anti-inflammatory cytokine that is a
            member of the class-2 cytokine family. The encoded protein is
            secreted by cells of both the innate and adaptive immune systems
            and is crucial for limiting the immune response to a broad range of
            pathogens. It also has been shown to suppress autoimmune responses.
            This protein mediates it's immunosuppressive signal through a
            specific interleukin 10 receptor complex. Aberrant functioning of
            this gene is associated with numerous immune disorders including
            graft-versus-host disease, and increased susceptibility to HIV-1
            infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152344.1, M37897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..178
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     Protein         1..178
                     /product="interleukin-10 precursor"
                     /note="cytokine synthesis inhibitory factor; interferon
                     2a"
                     /calculated_mol_wt=18754
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P18893.2)"
                     /calculated_mol_wt=1905
     Region          15..174
                     /region_name="IL10"
                     /note="Interleukin 10; pfam00726"
                     /db_xref="CDD:334228"
     mat_peptide     19..178
                     /product="Interleukin-10. /id=PRO_0000015367"
                     /note="propagated from UniProtKB/Swiss-Prot (P18893.2)"
                     /calculated_mol_wt=18754
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P18893.2)"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P18893.2)"
     CDS             1..178
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /coded_by="NM_010548.2:68..604"
                     /db_xref="CCDS:CCDS15265.1"
                     /db_xref="GeneID:16153"
                     /db_xref="MGI:MGI:96537"
ORIGIN      
        1 mpgsallccl llltgmrisr gqysrednnc thfpvgqshm llelrtafsq vktffqtkdq
       61 ldnilltdsl mqdfkgylgc qalsemiqfy lvevmpqaek hgpeikehln slgeklktlr
      121 mrlrrchrfl pcenkskave qvksdfnklq dqgvykamne fdifinciea ymmikmks
//
LOCUS       NP_031418                377 aa            linear   ROD 27-AUG-2025
DEFINITION  actin, aortic smooth muscle [Mus musculus].
ACCESSION   NP_031418 NP_899097
VERSION     NP_031418.1
DBSOURCE    REFSEQ: accession NM_007392.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Pan,Y., Wang,S., Yang,W., Wu,X., Zhang,H., Du,S., Zhang,M., Hou,L.,
            Plikus,M.V., Shuai,J., Lv,C., Yu,L. and Yu,Z.
  TITLE     Mesenchymal SLMAP coordinates with MST3 to govern gut elongation
            during development
  JOURNAL   Development 152 (20) (2025)
   PUBMED   40521668
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Kaw,A., Majumder,S., Esparza Pinelo,J.E., Wu,T., Starosolski,Z.,
            Zhou,Z., Pedroza,A.J., Duan,X., Kaw,K., Gonzalez,A.D., Sarkar,R.,
            Fischbein,M.P., Lorenzi,P.L., Tan,L., Martinez,S.A., Mahmud,I.,
            Devkota,L., Buja,L.M., Taegtmeyer,H., Ghaghada,K.B., Marrelli,S.P.,
            Kwartler,C.S. and Milewicz,D.M.
  TITLE     Immature Acta2R179C/+ smooth muscle cells cause moyamoya-like
            cerebrovascular lesions in mice prevented by boosting OXPHOS
  JOURNAL   Nat Commun 16 (1), 6105 (2025)
   PUBMED   40603847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Lin,S., Dieterich,C., Britto-Borges,T., Gunther,S., Kreher,S.,
            Eibach,Y., Kuenne,C., Schneider,A. and Braun,T.
  TITLE     Rbpms2 prevents major cardiac defects in cardiomyocyte-specific
            Rbpms-deficient mice
  JOURNAL   Dev Cell (2025) In press
   PUBMED   40602408
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Kashimada,A., Mizuno,T., Tanaka,E., Hosokawa,S., Udagawa,T.,
            Hiraoka,Y., Uchida,K., Morio,T., Kosaki,K. and Takagi,M.
  TITLE     De novo variant in RING finger protein 213 causes systemic
            vasculopathy
  JOURNAL   JCI Insight 10 (11), e190094 (2025)
   PUBMED   40485582
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Foster,D.N., Min,B., Foster,L.K., Stoflet,E.S., Sun,S., Getz,M.J.
            and Strauch,A.R.
  TITLE     Positive and negative cis-acting regulatory elements mediate
            expression of the mouse vascular smooth muscle alpha-actin gene
  JOURNAL   J Biol Chem 267 (17), 11995-12003 (1992)
   PUBMED   1601869
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Harris,D.E., Warshaw,D.M. and Periasamy,M.
  TITLE     Nucleotide sequences of the rabbit alpha-smooth-muscle and
            beta-non-muscle actin mRNAs
  JOURNAL   Gene 112 (2), 265-266 (1992)
   PUBMED   1555776
REFERENCE   8  (residues 1 to 377)
  AUTHORS   Rhyner,T.A., Lecain,E., Mallet,J. and Pessac,B.
  TITLE     Isolation of cDNAs from a mouse astroglial cell line by a
            subtracted cDNA library
  JOURNAL   J Neurosci Res 27 (2), 144-152 (1990)
   PUBMED   1701491
REFERENCE   9  (residues 1 to 377)
  AUTHORS   Min,B.H., Foster,D.N. and Strauch,A.R.
  TITLE     The 5'-flanking region of the mouse vascular smooth muscle
            alpha-actin gene contains evolutionarily conserved sequence motifs
            within a functional promoter
  JOURNAL   J Biol Chem 265 (27), 16667-16675 (1990)
   PUBMED   2398068
REFERENCE   10 (residues 1 to 377)
  AUTHORS   Schiffer,S.P., Prochazka,M., Jezyk,P.F., Roderick,T.H., Yudkoff,M.
            and Patterson,D.F.
  TITLE     Organic aciduria and butyryl CoA dehydrogenase deficiency in
            BALB/cByJ mice
  JOURNAL   Biochem Genet 27 (1-2), 47-58 (1989)
   PUBMED   2712823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC102285.7 and AK017374.1.
            
            On Apr 20, 2005 this sequence version replaced NP_899097.1.
            
            Summary: The protein encoded by this gene belongs to the actin
            family of proteins, which are highly conserved proteins that play a
            role in cell motility, structure and integrity. Alpha, beta and
            gamma actin isoforms have been identified, with alpha actins being
            a major constituent of the contractile apparatus, while beta and
            gamma actins are involved in the regulation of cell motility. This
            actin is an alpha actin that is found in smooth muscle. [provided
            by RefSeq, Feb 2021].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017374.1, AK156331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.41 cM"
     Protein         1..377
                     /product="actin, aortic smooth muscle"
                     /note="alpha-actin-2; actin, alpha, vascular smooth
                     muscle"
                     /calculated_mol_wt=41878
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylcysteine, in intermediate form.
                     /evidence=ECO:0000269|PubMed:36173861,
                     ECO:0000269|PubMed:6725286; propagated from
                     UniProtKB/Swiss-Prot (P62737.1)"
     mat_peptide     3..377
                     /product="Actin, aortic smooth muscle.
                     /evidence=ECO:0000269|PubMed:6725286. /id=PRO_0000442606"
                     /note="propagated from UniProtKB/Swiss-Prot (P62737.1)"
                     /calculated_mol_wt=41775
     Site            3
                     /site_type="acetylation"
                     /note="N-acetylglutamate, in Actin, aortic smooth muscle.
                     /evidence=ECO:0000269|PubMed:6725286; propagated from
                     UniProtKB/Swiss-Prot (P62737.1)"
     Region          8..372
                     /region_name="ASKHA_NBD_actin"
                     /note="nucleotide-binding domain (NBD) of actin and
                     similar proteins; cd10224"
                     /db_xref="CDD:466823"
     Site            75
                     /site_type="methylation"
                     /note="Tele-methylhistidine.
                     /evidence=ECO:0000250|UniProtKB:P62739; propagated from
                     UniProtKB/Swiss-Prot (P62737.1)"
     Site            86
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P68032; propagated from
                     UniProtKB/Swiss-Prot (P62737.1)"
     CDS             1..377
                     /gene="Acta2"
                     /gene_synonym="0610041G09Rik; a-SMA; Actvs; alphaSMA;
                     SMAalpha; SMalphaA"
                     /coded_by="NM_007392.3:108..1241"
                     /db_xref="CCDS:CCDS29757.1"
                     /db_xref="GeneID:11475"
                     /db_xref="MGI:MGI:87909"
ORIGIN      
        1 mceeedstal vcdngsglck agfagddapr avfpsivgrp rhqgvmvgmg qkdsyvgdea
       61 qskrgiltlk ypiehgiitn wddmekiwhh sfynelrvap eehptlltea plnpkanrek
      121 mtqimfetfn vpamyvaiqa vlslyasgrt tgivldsgdg vthnvpiyeg yalphaimrl
      181 dlagrdltdy lmkiltergy sfvttaerei vrdikeklcy valdfenema taasssslek
      241 syelpdgqvi tignerfrcp etlfqpsfig mesagihett ynsimkcdid irkdlyannv
      301 lsggttmypg iadrmqkeit alapstmkik iiapperkys vwiggsilas lstfqqmwis
      361 kqeydeagps ivhrkcf
//
LOCUS       NP_112466                224 aa            linear   ROD 27-AUG-2025
DEFINITION  myogenin [Mus musculus].
ACCESSION   NP_112466
VERSION     NP_112466.1
DBSOURCE    REFSEQ: accession NM_031189.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Zuo,H., Jiang,W., Gao,J., Ma,Z., Li,C., Peng,Y., Jin,J., Zhan,X.,
            Lv,W., Liu,X., Hu,J., Zhang,M., Jia,Y., Xu,Z., Tang,J., Zheng,R.
            and Zuo,B.
  TITLE     SYISL Knockout Promotes Embryonic Muscle Development of Offspring
            by Modulating Maternal Gut Microbiota and Fetal Myogenic Cell
            Dynamics
  JOURNAL   Adv Sci (Weinh) 12 (6), e2410953 (2025)
   PUBMED   39680624
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 224)
  AUTHORS   Lu,Y., Walji,T., Ravaux,B., Pandey,P., Yang,C., Li,B.,
            Luvsanjav,D., Lam,K.H., Zhang,R., Luo,Z., Zhou,C., Habela,C.W.,
            Snapper,S.B., Li,R., Goldhamer,D.J., Schmidtke,D.W., Pan,D.,
            Svitkina,T.M. and Chen,E.H.
  TITLE     Spatiotemporal coordination of actin regulators generates invasive
            protrusions in cell-cell fusion
  JOURNAL   Nat Cell Biol 26 (11), 1860-1877 (2024)
   PUBMED   39487253
REFERENCE   5  (residues 1 to 224)
  AUTHORS   Kawasaki,M., Kawasaki,K., Sari,F.T., Kudo,T., Nihara,J.,
            Kitamura,M., Nagai,T., Utama,V., Ishida,Y., Meguro,F., Kesuma,A.,
            Fujita,A., Nishimura,T., Kogure,Y., Maruyama,S., Tanuma,J.I.,
            Kakihara,Y., Maeda,T., Ghafoor,S., Khonsari,R.H., Corre,P.,
            Sharpe,P.T., Cobourne,M., Franco,B. and Ohazama,A.
  TITLE     Cell-cell interaction determines cell fate of mesoderm-derived cell
            in tongue development through Hh signaling
  JOURNAL   Elife 13, e85042 (2024)
   PUBMED   39392396
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 224)
  AUTHORS   Wolf,J.R., Hirschhorn,R.R. and Steiner,S.M.
  TITLE     Growth factor responsiveness: role of MyoD and myogenin
  JOURNAL   Exp Cell Res 202 (1), 105-112 (1992)
   PUBMED   1324843
REFERENCE   7  (residues 1 to 224)
  AUTHORS   Edmondson,D.G., Cheng,T.C., Cserjesi,P., Chakraborty,T. and
            Olson,E.N.
  TITLE     Analysis of the myogenin promoter reveals an indirect pathway for
            positive autoregulation mediated by the muscle-specific enhancer
            factor MEF-2
  JOURNAL   Mol Cell Biol 12 (9), 3665-3677 (1992)
   PUBMED   1324403
REFERENCE   8  (residues 1 to 224)
  AUTHORS   Wang,Y., Benezra,R. and Sassoon,D.A.
  TITLE     Id expression during mouse development: a role in morphogenesis
  JOURNAL   Dev Dyn 194 (3), 222-230 (1992)
   PUBMED   1361374
REFERENCE   9  (residues 1 to 224)
  AUTHORS   Yamaguchi,T.P., Conlon,R.A. and Rossant,J.
  TITLE     Expression of the fibroblast growth factor receptor FGFR-1/flg
            during gastrulation and segmentation in the mouse embryo
  JOURNAL   Dev Biol 152 (1), 75-88 (1992)
   PUBMED   1321062
REFERENCE   10 (residues 1 to 224)
  AUTHORS   Fuchtbauer,E.M. and Westphal,H.
  TITLE     MyoD and myogenin are coexpressed in regenerating skeletal muscle
            of the mouse
  JOURNAL   Dev Dyn 193 (1), 34-39 (1992)
   PUBMED   1311614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ096370.1 and BC048683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048683.1, X15784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.18 cM"
     Protein         1..224
                     /product="myogenin"
                     /note="MYOD1-related protein"
                     /calculated_mol_wt=25072
     Region          1..86
                     /region_name="BASIC"
                     /note="Basic domain in HLH proteins of MYOD family;
                     smart00520"
                     /db_xref="CDD:128794"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2G.
                     /evidence=ECO:0000250|UniProtKB:P20428; propagated from
                     UniProtKB/Swiss-Prot (P12979.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2G.
                     /evidence=ECO:0000250|UniProtKB:P20428; propagated from
                     UniProtKB/Swiss-Prot (P12979.2)"
     Region          81..139
                     /region_name="bHLH_TS_MYOG_Myf4"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     myogenin (MYOG) and similar proteins; cd18935"
                     /db_xref="CDD:381505"
     Site            order(82..83,87,89..91,93,98,115..118)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381505"
     Site            87
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CaMK2G.
                     /evidence=ECO:0000250|UniProtKB:P20428; propagated from
                     UniProtKB/Swiss-Prot (P12979.2)"
     Site            order(96..97,100..101,103..104,119,122,126,128..129,133,
                     135..136)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381505"
     CDS             1..224
                     /gene="Myog"
                     /gene_synonym="bHLHc3; MYF4; myo"
                     /coded_by="NM_031189.2:53..727"
                     /db_xref="CCDS:CCDS15306.1"
                     /db_xref="GeneID:17928"
                     /db_xref="MGI:MGI:97276"
ORIGIN      
        1 melyetspyf yqephfydge nylpvhlqgf eppgyertel slspeargpl eekglgtpeh
       61 cpgqclpwac kvckrksvsv drrraatlre krrlkkvnea fealkrstll npnqrlpkve
      121 ilrsaiqyie rlqallssln qeerdlryrg gggpqpmvps ecnshsascs pewgnalefg
      181 pnpgdhllaa dptdahnlhs ltsivdsitv edmsvafpde tmpn
//
LOCUS       NP_032765               2691 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 1
            [Mus musculus].
ACCESSION   NP_032765 XP_622088
VERSION     NP_032765.3
DBSOURCE    REFSEQ: accession NM_008739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2691)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2691)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2691)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 2691)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 2691)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 2691)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 2691)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 2691)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 2691)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 2691)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145783.1, AC160958.2, CD549506.1, BQ442794.1, CB247038.1,
            CD806124.1, CN529078.1, CA318563.1, BQ917954.1 and BI737132.1.
            
            On Dec 7, 2006 this sequence version replaced NP_032765.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..2691
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 1"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=296235
     Region          319..434
                     /region_name="PWWP_NSD1_rpt1"
                     /note="first PWWP domain found in nuclear receptor-binding
                     SET domain-containing protein 1 (NSD1) and similar
                     proteins; cd20161"
                     /db_xref="CDD:438989"
     Site            order(335,338,369)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438989"
     Site            336..339
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438989"
     Site            order(407..409,412..413)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438989"
     Region          <1453..1587
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          1546..1587
                     /region_name="PHD1_NSD1_2"
                     /note="PHD finger 1 found in nuclear receptor-binding SET
                     domain-containing protein NSD1 and NSD2; cd15648"
                     /db_xref="CDD:277118"
     Site            order(1546,1555..1559,1564,1582)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277118"
     Region          1593..1639
                     /region_name="PHD2_NSD1"
                     /note="PHD finger 2 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15650"
                     /db_xref="CDD:277120"
     Site            order(1593,1603..1607,1613,1634)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277120"
     Region          1640..1693
                     /region_name="PHD3_NSD1"
                     /note="PHD finger 3 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15653"
                     /db_xref="CDD:277123"
     Site            order(1640,1658..1662,1666,1688)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277123"
     Region          1710..1749
                     /region_name="PHD4_NSD1"
                     /note="PHD finger 4 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15656"
                     /db_xref="CDD:277126"
     Site            order(1710,1719..1723,1727,1744)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277126"
     Region          1756..1851
                     /region_name="PWWP_NSD1_rpt2"
                     /note="second PWWP domain found in nuclear
                     receptor-binding SET domain-containing protein 1 (NSD1)
                     and similar proteins; cd20164"
                     /db_xref="CDD:438992"
     Site            order(1768,1771,1799)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438992"
     Site            1769..1772
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438992"
     Region          1902..1940
                     /region_name="AWS"
                     /note="AWS domain; pfam17907"
                     /db_xref="CDD:465559"
     Region          1942..2083
                     /region_name="SET_NSD1"
                     /note="SET domain (including post-SET domain) found in
                     nuclear receptor-binding SET domain-containing protein 1
                     (NSD1) and similar proteins; cd19210"
                     /db_xref="CDD:380987"
     Site            order(1953..1955,1972,1982,1986,1995..2001,2018..2022,
                     2029..2031,2046,2057..2067,2069..2073,2082)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380987"
     Site            order(1953..1955,1995..1998,2018..2022,2059,2066,
                     2070..2073,2082)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380987"
     Site            order(1972,1982,1986,1997..2001,2029..2031,2046,
                     2057..2061)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:380987"
     Site            order(2024,2071,2073,2078)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:380987"
     Region          2121..2163
                     /region_name="PHD5_NSD1"
                     /note="PHD finger 5 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15659"
                     /db_xref="CDD:277129"
     Site            order(2121,2130..2134,2140,2158)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277129"
     Region          2162..2211
                     /region_name="C5HCH"
                     /note="NSD Cys-His rich domain; pfam17982"
                     /db_xref="CDD:465605"
     Region          2255..>2576
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..2691
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_008739.3:112..8187"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36673.1"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mdrtcelsrr ncllsfsnpv nldasedkds pfgngqsnfs eplngctmql ptaasgtsqn
       61 aygqdspscy iplrrlqdla sminveylsg sadgsesfqd paksdsraqs pivctslspg
      121 gptalamkqe ptcnnspelq lrvtkttkng flhfenftgv ddadvdsemd peqpvtedes
      181 ieeifeetqt natcnyepks engvevamgs eqdsmpesrh gaverpflpl apqtekqknk
      241 qrsevdgsne ktallpapts lgdtnvtvee qfnsinlsfq ddpdsspspl gnmleipgts
      301 spstsqelpf cqpkkkstpl kyevgdliwa kfkrrpwwpc ricsdplint hskmkvanrr
      361 pyreyyveaf gdpsekawva gkaivmfegr hqfeelpvlr krgkqkekgy rhkvpqkils
      421 kweasvglae qydvpkgskn qkcvsssvkl dseedmpfed ctndpdsehl llngclksla
      481 fdsehsadek ekpcaksrvr kssdnikrts vkkdlvpfes rkeerrgkip dnlgldfisg
      541 gvsdkqasne lsriansltg sstapgsflf sssvqntakt dfetpdcdsl sglsesalis
      601 khsgekkklq pgqvcsskvq lcyvgagdee krsnsvsvst tsddgcsdld ptehnsgfqn
      661 svlgitdafd ktenalsvhk netqysrypv tnrikekqks litnshadhl mgstktmepe
      721 taelsqvnls dlkisspipk pqpefrndgl ttkfsappgi rnenpltkgg lanqtllplk
      781 crqpkfrsik ckhkespava etsatsedls lkccssdtng splanisksg kgeglkllnn
      841 mhektrdssd ietavvkhvl selkelsyrs lsedvsdsgt akaskpllfs sassqnhipi
      901 epdykfstll mmlkdmhdsk tkeqrlmtaq nlasyrtpdr gdcssgspvg tskvlvlgss
      961 tpnsekpgds tqdsvhqspg ggdsalsgel ssslsslasd krelpacgki rsnciprrnc
     1021 grakpssklr etisaqmvkp svnpkalkte rkrkfsrlpa vtlaanrlgn kesgsvngps
     1081 rggaedpgke eplqqmdllr nedthfsdvh fdskakqsdp dknlekepsf enrkgpelgs
     1141 emntendelh gvnqvvpkkr wqrlnqrrpk pgkranrfre kensegafgv llpadavqka
     1201 redyleqrap ptskpedsaa dpnhgshses vaprlnvcek ssvgmgdvek etgipslmpq
     1261 tklpepairs ekkrlrkpsk wlleyteeyd qifapkkkqk kvqeqvhkvs srcedeslla
     1321 rcqpsaqnkq vdenslistk eeppvlerea pflegplaqs dlgvthaelp qltlsvpvap
     1381 easprpales eellvktpgn yeskrqrkpt kkllesndld pgfmpkkgdl glsrkcfeas
     1441 rsgngivesr atshlkefsg gttkifdkpr krkrqrlvta rvhykkvkke dltkdtpsse
     1501 gellihrtaa spkeileegv ehdpgmsask klqverggga alkenvcqnc eklgelllce
     1561 aqccgafhle clglpemprg kficnechtg ihtcfvckqs gedvkrcllp lcgkfyheec
     1621 vqkypptvtq nkgfrcplhi citchaanpa nvsaskgrlm rcvrcpvayh andfclaags
     1681 kilasnsiic pnhftprrgc rnhehvnvsw cfvcseggsl lccdscpaaf hreclnidip
     1741 egnwycndck agkkphyrei vwvkvgryrw wpaeichpra vpsnidkmrh dvgefpvlff
     1801 gsndylwthq arvfpymegd vsskdkmgkg vdgtykkalq eaaarfeelk aqkelrqlqe
     1861 drkndkkppp ykhikvnrpi grvqiftadl seiprcncka tdenpcgids ecinrmllye
     1921 chptvcpagv rcqnqcfskr qypdveifrt lqrgwglrtk tdikkgefvn eyvgelidee
     1981 ecrariryaq ehditnfyml tldkdriida gpkgnyarfm nhccqpncet qkwsvngdtr
     2041 vglfalsdik agteltfnyn leclgngktv ckcgapncsg flgvrpknqp ivteeksrkf
     2101 krkphgkrrs qgevtkered ecfscgdagq lvsckkpgcp kvyhadclnl tkrpagkwec
     2161 pwhqcdvcgk eaasfcemcp ssfckqhreg mlfiskldgr lsctehdpcg pnplepgeir
     2221 eyvpptatsp pspgtqpkeq ssematqgpk ksdqpptdat qllplskkal tgscqrpllp
     2281 erppertdss shlldrirdl agsgtksqsl vssqrpqdrp pakegprpqp pdraspmtrp
     2341 ssspsvsslp lerplrmtds rldksigaas pksqavektp astglrlssp drllttnspk
     2401 pqisdrppek shasltqrlp ppekvlsavv qslvakekal rpvdqntqsk hrpavvmdli
     2461 dltprqkera aspqevtpqa dektamless swpsskglgh ipratekisv seslqpsgkv
     2521 aapsehpwqa vksltharfl sppsakafly esatqasgrt pvgaeqtpgp pspapglvkq
     2581 vkqlsrglta ksgqsfrslg kisaslpnee kklttteqsp wglgkaspga glwpivagqt
     2641 laqacwsagg tqtlaqtcws lgrgqdpkpe naiqalnqap ssrkcadsek k
//
LOCUS       NP_001334437             449 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon regulatory factor 4 isoform b [Mus musculus].
ACCESSION   NP_001334437 XP_006516623
VERSION     NP_001334437.1
DBSOURCE    REFSEQ: accession NM_001347508.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Tadepalli,S., Clements,D.R., Raquer-McKay,H.M., Ludtke,A.,
            Saravanan,S., Seong,D., Vitek,L., Richards,C.M., Carette,J.E.,
            Mack,M., Gottfried-Blackmore,A., Graves,E.E. and Idoyaga,J.
  TITLE     CD301b+ monocyte-derived dendritic cells mediate resistance to
            radiotherapy
  JOURNAL   J Exp Med 222 (6) (2025)
   PUBMED   40146036
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Gao,X., Shen,X., Xu,Q., Zeng,Y., Dong,L., Hong,S., Jin,H., Wang,Q.,
            Wang,D., Lu,L. and Wang,L.
  TITLE     The transcription factor IRF4 regulates the homeostasis and
            function of intestinal ILC3s
  JOURNAL   iScience 28 (7), 112800 (2025)
   PUBMED   40585371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 449)
  AUTHORS   Gabele,A., Sprang,M., Cihan,M., Welzel,M., Nurbekova,A.,
            Romaniuk,K., Dietzen,S., Klein,M., Bundgen,G., Emelianov,M.,
            Harms,G., Rajalingam,K., Ziesmann,T., Pape,K., Wasser,B.,
            Gomez-Zepeda,D., Braband,K., Delacher,M., Lemmermann,N.,
            Bittner,S., Andrade-Navarro,M.A., Tenzer,S., Luck,K., Bopp,T. and
            Distler,U.
  TITLE     Unveiling IRF4-steered regulation of context-dependent effector
            programs in CD4+ T cells under Th17- and Treg-skewing conditions
  JOURNAL   Cell Rep 44 (3), 115407 (2025)
   PUBMED   40067830
REFERENCE   5  (residues 1 to 449)
  AUTHORS   Zhou,L., Lin,P., Deng,G., Mo,L., Hong,C., Jiang,Z., Zhu,Y.,
            Zhao,Y., Qi,Y., Hu,T., Wu,Q., Zhang,J., Li,Q. and Yang,Q.
  TITLE     IRF4 regulates myeloid-derived suppressor cells expansion and
            function in Schistosoma japonicum-infected mice
  JOURNAL   Parasit Vectors 17 (1), 492 (2024)
   PUBMED   39609883
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 449)
  AUTHORS   Mittrucker,H.W., Matsuyama,T., Grossman,A., Kundig,T.M., Potter,J.,
            Shahinian,A., Wakeham,A., Patterson,B., Ohashi,P.S. and Mak,T.W.
  TITLE     Requirement for the transcription factor LSIRF/IRF4 for mature B
            and T lymphocyte function
  JOURNAL   Science 275 (5299), 540-543 (1997)
   PUBMED   8999800
REFERENCE   7  (residues 1 to 449)
  AUTHORS   Grossman,A., Mittrucker,H.W., Nicholl,J., Suzuki,A., Chung,S.,
            Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P. and Mak,T.W.
  TITLE     Cloning of human lymphocyte-specific interferon regulatory factor
            (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
  JOURNAL   Genomics 37 (2), 229-233 (1996)
   PUBMED   8921401
REFERENCE   8  (residues 1 to 449)
  AUTHORS   Henkel,G.W., McKercher,S.R., Yamamoto,H., Anderson,K.L.,
            Oshima,R.G. and Maki,R.A.
  TITLE     PU.1 but not ets-2 is essential for macrophage development from
            embryonic stem cells
  JOURNAL   Blood 88 (8), 2917-2926 (1996)
   PUBMED   8874188
REFERENCE   9  (residues 1 to 449)
  AUTHORS   Matsuyama,T., Grossman,A., Mittrucker,H.W., Siderovski,D.P.,
            Kiefer,F., Kawakami,T., Richardson,C.D., Taniguchi,T.,
            Yoshinaga,S.K. and Mak,T.W.
  TITLE     Molecular cloning of LSIRF, a lymphoid-specific member of the
            interferon regulatory factor family that binds the
            interferon-stimulated response element (ISRE)
  JOURNAL   Nucleic Acids Res 23 (12), 2127-2136 (1995)
   PUBMED   7541907
REFERENCE   10 (residues 1 to 449)
  AUTHORS   Eisenbeis,C.F., Singh,H. and Storb,U.
  TITLE     Pip, a novel IRF family member, is a lymphoid-specific,
            PU.1-dependent transcriptional activator
  JOURNAL   Genes Dev 9 (11), 1377-1387 (1995)
   PUBMED   7797077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645745.7 and AK089319.1.
            
            On Nov 30, 2016 this sequence version replaced XP_006516623.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is 1 aa shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.28 cM"
     Protein         1..449
                     /product="interferon regulatory factor 4 isoform b"
                     /note="PU.1 interaction partner; transcriptional activator
                     PIP; lymphocyte-specific interferon regulatory factor;
                     Sfpi1/PU.1 interaction partner"
                     /calculated_mol_wt=51318
     Region          23..128
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(56,96,98..99,102)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            order(101..102,104,107)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          248..417
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:463076"
     Site            445
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK2.
                     /evidence=ECO:0000269|PubMed:20697158; propagated from
                     UniProtKB/Swiss-Prot (Q64287.1)"
     Site            446
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK2.
                     /evidence=ECO:0000269|PubMed:20697158; propagated from
                     UniProtKB/Swiss-Prot (Q64287.1)"
     CDS             1..449
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /coded_by="NM_001347508.1:96..1445"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS84017.1"
                     /db_xref="GeneID:16364"
                     /db_xref="MGI:MGI:1096873"
ORIGIN      
        1 mnletgsrgs efgmsavscg ngklrqwlid qidsgkypgl vweneeksvf ripwkhagkq
       61 dynreedaal fkawalfkgk fregidkpdp ptwktrlrca lnksndfeel versqldisd
      121 pykvyrivpe gakkgakqlt lddtqmamgh pypmtapygs lpaqvhnymm pphdrswrdy
      181 apdqshpeip yqcpvtfgpr ghhwqgpsce ngcqvtgtfy acappesqap gipiepsirs
      241 aealalsdcr lhiclyyrdi lvkeltttsp egcrishght ydvsnldqvl fpypddngqr
      301 kniekllshl erglvlwmap dglyakrlcq sriywdgpla lcsdrpnkle rdqtcklfdt
      361 qqflselqvf ahhgrpaprf qvtlcfgeef pdpqrqrkli tahvepllar qlyyfaqqnt
      421 ghflrgyelp ehvttpdyhr slrhssiqe
//
LOCUS       NP_001277955            1274 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase PRDM16 isoform 3 [Mus musculus].
ACCESSION   NP_001277955 XP_006539239
VERSION     NP_001277955.1
DBSOURCE    REFSEQ: accession NM_001291026.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1274)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1274)
  AUTHORS   Fu,L., Upadhyay,R., Pokrovskii,M., Chen,F.M., Romero-Meza,G.,
            Griesemer,A. and Littman,D.R.
  TITLE     PRDM16-dependent antigen-presenting cells induce tolerance to gut
            antigens
  JOURNAL   Nature 642 (8068), 756-765 (2025)
   PUBMED   40228524
REFERENCE   3  (residues 1 to 1274)
  AUTHORS   Zhang,H., Papiernik,T., Tian,S., Yaghmour,A., Alzein,A.,
            Lennon,J.B., Maini,R., Tan,X., Niazi,A., Park,J., Park,S.,
            Richter,C.P. and Ebeid,M.
  TITLE     Kolliker's Organ Functions as a Developmental Hub in Mouse Cochlea
            Regulating Spiral Limbus and Tectorial Membrane Development
  JOURNAL   J Neurosci 45 (13), e0721242025 (2025)
   PUBMED   39909560
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1274)
  AUTHORS   Wang,S., He,T., Luo,Y., Ren,K., Shen,H., Hou,L., Wei,Y., Fu,T.,
            Xie,W., Wang,P., Hu,J., Zhu,Y., Huang,Z., Li,Q., Li,W., Guo,H. and
            Li,B.
  TITLE     SOX4 facilitates brown fat development and maintenance through
            EBF2-mediated thermogenic gene program in mice
  JOURNAL   Cell Death Differ 32 (3), 447-465 (2025)
   PUBMED   39402212
REFERENCE   5  (residues 1 to 1274)
  AUTHORS   Wang,Y., Li,X., Liu,C., Zhou,L., Shi,L., Zhang,Z., Chen,L., Gao,M.,
            Gao,L., Xu,Y., Huang,H., Li,J. and Chen,Z.
  TITLE     WTAP regulates postnatal development of brown adipose tissue by
            stabilizing METTL3 in mice
  JOURNAL   Life Metab 1 (3), 270-284 (2022)
   PUBMED   39872074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1274)
  AUTHORS   Seale,P., Kajimura,S., Yang,W., Chin,S., Rohas,L.M., Uldry,M.,
            Tavernier,G., Langin,D. and Spiegelman,B.M.
  TITLE     Transcriptional control of brown fat determination by PRDM16
  JOURNAL   Cell Metab 6 (1), 38-54 (2007)
   PUBMED   17618855
REFERENCE   7  (residues 1 to 1274)
  AUTHORS   Warner,D.R., Horn,K.H., Mudd,L., Webb,C.L., Greene,R.M. and
            Pisano,M.M.
  TITLE     PRDM16/MEL1: a novel Smad binding protein expressed in murine
            embryonic orofacial tissue
  JOURNAL   Biochim Biophys Acta 1773 (6), 814-820 (2007)
   PUBMED   17467076
  REMARK    GeneRIF: PRDM16/MEL1 is a Smad binding protein that may be
            important for development of orofacial structures through
            modulation of the TGFbeta signaling pathway.
REFERENCE   8  (residues 1 to 1274)
  AUTHORS   Du,Y., Jenkins,N.A. and Copeland,N.G.
  TITLE     Insertional mutagenesis identifies genes that promote the
            immortalization of primary bone marrow progenitor cells
  JOURNAL   Blood 106 (12), 3932-3939 (2005)
   PUBMED   16109773
REFERENCE   9  (residues 1 to 1274)
  AUTHORS   Nishikata,I., Sasaki,H., Iga,M., Tateno,Y., Imayoshi,S., Asou,N.,
            Nakamura,T. and Morishita,K.
  TITLE     A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is
            expressed mainly in t(1;3)(p36;q21)-positive AML and blocks
            G-CSF-induced myeloid differentiation
  JOURNAL   Blood 102 (9), 3323-3332 (2003)
   PUBMED   12816872
REFERENCE   10 (residues 1 to 1274)
  AUTHORS   Herron,B.J., Lu,W., Rao,C., Liu,S., Peters,H., Bronson,R.T.,
            Justice,M.J., McDonald,J.D. and Beier,D.R.
  TITLE     Efficient generation and mapping of recessive developmental
            mutations using ENU mutagenesis
  JOURNAL   Nat Genet 30 (2), 185-189 (2002)
   PUBMED   11818962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627127.20, AL611950.17, AL627226.16 and AL627123.13.
            
            On Mar 22, 2014 this sequence version replaced XP_006539239.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083829.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1274
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.96 cM"
     Protein         1..1274
                     /product="histone-lysine N-methyltransferase PRDM16
                     isoform 3"
                     /EC_number="2.1.1.367"
                     /note="transcription factor MEL1; MDS1/EVI1-like gene 1;
                     PR domain-containing protein 16; PR domain zinc finger
                     protein 16; line 27; histone-lysine N-methyltransferase
                     PRDM16"
                     /calculated_mol_wt=140600
     Region          1..66
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          61..221
                     /region_name="PR-SET_PRDM16"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 16 (PRDM16) and similar proteins; cd19213"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,113,156,169..173,175,184..185,209)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,169..173,175,209)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380990"
     Region          231..251
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          281..303
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          283..303
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(288,290,292,294..295,298..299,302,316,318,322..323,
                     326..327,330,344,346,348,350..351,354..355)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          295..319
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          309..331
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          311..331
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          337..358
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          339..357
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          366..388
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          368..388
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          394..416
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          396..416
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          425..443
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          591..657
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          679..1037
                     /region_name="Interaction with CTBP1, CTBP2 and ZNF516.
                     /evidence=ECO:0000269|PubMed:18483224"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          739..1274
                     /region_name="Mediates interaction with SKI and regulation
                     of TGF-beta signaling.
                     /evidence=ECO:0000250|UniProtKB:Q9HAZ2"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          788..837
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          950..972
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          952..972
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(957,959,961,963..964,967..968,971,985,987,991..992,
                     995..996,1000,1014,1016,1018,1020..1021,1024..1025,1028)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          964..988
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          980..>1014
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          980..1006
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          980..1001
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(985,991,1003,1005,1008)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          1007..1029
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          1009..1029
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1026..1064
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          1083..1168
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     CDS             1..1274
                     /gene="Prdm16"
                     /gene_synonym="5730557K01Rik; csp1; mel1"
                     /coded_by="NM_001291026.2:58..3882"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS71530.1"
                     /db_xref="GeneID:70673"
                     /db_xref="MGI:MGI:1917923"
ORIGIN      
        1 mrskararkl aksdgdvvnn myepdpdlla gqsaeeeted gilspipmgp pspfptsedf
       61 tpkegspyea pvyipedipi ppdfelress ipgaglgiwa krkmeigerf gpyvvtpraa
      121 lkeadfgwem ltdtevssqe scikkisedl gsekfcvdan qagsgswlky irvacscddq
      181 nlamcqineq iyykvikdie pgeellvhvk egayslgvma psldedptfr cdecdelfqc
      241 rldlrrhkky acssagaqly eglgeelkpe glgvgsdgqa heckdcermf pnkysleqhm
      301 ivhteereyk cdqcpkafnw ksnlirhqms hdsgkrfece ncvkvftdps nlqrhirsqh
      361 vgarahacpd cgktfatssg lkqhkhihst vkpficevch ksytqfsnlc rhkrmhadcr
      421 tqikckdcgq mfsttsslnk hrrfcegknh ytpgsiftpg lpltpspmmd ktkpsptlnh
      481 gglgfseyfp srphpgslpf saappafpal tpgfpgifpp slyprppllp ptpllkspln
      541 haqdaklpsp lgnpalplvs avsnssqgat aatgseekfd grledayaek vknrspdmsd
      601 gsdfedintt tgtdldtttg tgsdldsdld sdrdkgkdkg kpveskpefg gasvppgamn
      661 svaevpafys qhsffpppee qlltasgaag dsikaiasia ekyfgpgfms mqekklgslp
      721 yhsvfpfqfl pnfphslypf tdralahnll vkaepksprd alkvggpsae cpfdlttkpk
      781 eakpallapk vplipssgee qpldlsigsr arasqngggr eprknhvyge rkpgvseglp
      841 kvcpaqlpqq pslhyakpsp ffmdpiyrve krkvadpvgv lkekylrpsp llfhpqmsai
      901 etmteklesf aamkadsgss lqplphhpfn frsppptlsd pilrkgkery tcrycgkifp
      961 rsanltrhlr thtgeqpyrc kycdrsfsis snlqrhvrni hnkekpfkch lcnrcfgqqt
     1021 nldrhlkkhe hegapvsqhs gvltnhlgts assptsesdn halldekeds yfseirnfia
     1081 nsemnqastr mdkrpeiqdl dsnppcpgsa sakpedveee eeeeleeedd dslagksqed
     1141 tvsptpepqg vyedeedeep psltmgfdht rrcveerggg llaleptptf gkgldlrraa
     1201 eeafevkdvl nstldsevlk qtlyrqaknq ayammlslse dtplhapsqs sldawlnitg
     1261 pssesgafnp inhl
//
LOCUS       NP_079816                 31 aa            linear   ROD 27-AUG-2025
DEFINITION  sarcolipin [Mus musculus].
ACCESSION   NP_079816
VERSION     NP_079816.1
DBSOURCE    REFSEQ: accession NM_025540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 31)
  AUTHORS   Ihara,K., Iwamiya,S., Ikuta,M., Soejima,Y., Hiraoka,Y., Nakano,A.,
            Minamisawa,S., Furukawa,T., Kuroyanagi,H. and Sasano,T.
  TITLE     Cytoplasmic mutant RBM20 causes arrhythmogenicity in murine atria
  JOURNAL   J Mol Cell Cardiol 205, 1-12 (2025)
   PUBMED   40480405
REFERENCE   2  (residues 1 to 31)
  AUTHORS   Skop,V., Liu,N., Xiao,C., Stinson,E., Chen,K.Y., Hall,K.D.,
            Piaggi,P., Gavrilova,O. and Reitman,M.L.
  TITLE     Beyond day and night: The importance of ultradian rhythms in mouse
            physiology
  JOURNAL   Mol Metab 84, 101946 (2024)
   PUBMED   38657735
REFERENCE   3  (residues 1 to 31)
  AUTHORS   Mareedu,S., Fefelova,N., Galindo,C.L., Prakash,G., Mukai,R.,
            Sadoshima,J., Xie,L.H. and Babu,G.J.
  TITLE     Improved mitochondrial function in the hearts of
            sarcolipin-deficient dystrophin and utrophin double-knockout mice
  JOURNAL   JCI Insight 9 (9), e170185 (2024)
   PUBMED   38564291
  REMARK    GeneRIF: Improved mitochondrial function in the hearts of
            sarcolipin-deficient dystrophin and utrophin double-knockout mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 31)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 31)
  AUTHORS   Su,K.N., Ma,Y., Cacheux,M., Ilkan,Z., Raad,N., Muller,G.K., Wu,X.,
            Guerrera,N., Thorn,S.L., Sinusas,A.J., Foretz,M., Viollet,B.,
            Akar,J.G., Akar,F.G. and Young,L.H.
  TITLE     Atrial AMP-activated protein kinase is critical for prevention of
            dysregulation of electrical excitability and atrial fibrillation
  JOURNAL   JCI Insight 7 (8), e141213 (2022)
   PUBMED   35451373
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 31)
  AUTHORS   Shimura,M., Minamisawa,S., Yokoyama,U., Umemura,S. and Ishikawa,Y.
  TITLE     Mechanical stress-dependent transcriptional regulation of
            sarcolipin gene in the rodent atrium
  JOURNAL   Biochem Biophys Res Commun 334 (3), 861-866 (2005)
   PUBMED   16036219
  REMARK    GeneRIF: we generated left-sided pressure-overload models by
            transverse aortic constriction (TAC) in ddY mice.  TAC
            significantly decreased the expression of sarcolipin, SERCA2a, and
            phospholamban mRNAs in the left atrium (LA) than those in the right
            atrium (RA).
REFERENCE   7  (residues 1 to 31)
  AUTHORS   Vangheluwe,P., Schuermans,M., Zador,E., Waelkens,E., Raeymaekers,L.
            and Wuytack,F.
  TITLE     Sarcolipin and phospholamban mRNA and protein expression in cardiac
            and skeletal muscle of different species
  JOURNAL   Biochem J 389 (Pt 1), 151-159 (2005)
   PUBMED   15801907
  REMARK    GeneRIF: The expression of SLN and PLB mRNA and protein relative to
            SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal
            msucle of mouse, rat, rabbit and pig.
REFERENCE   8  (residues 1 to 31)
  AUTHORS   Gramolini,A.O., Kislinger,T., Asahi,M., Li,W., Emili,A. and
            MacLennan,D.H.
  TITLE     Sarcolipin retention in the endoplasmic reticulum depends on its
            C-terminal RSYQY sequence and its interaction with
            sarco(endo)plasmic Ca(2+)-ATPases
  JOURNAL   Proc Natl Acad Sci U S A 101 (48), 16807-16812 (2004)
   PUBMED   15556994
  REMARK    GeneRIF: retention of sarcolipin in the endoplasmic reticulum is
            mediated through its association with other components through the
            C-terminal RSYQY sequence
REFERENCE   9  (residues 1 to 31)
  AUTHORS   Asahi,M., Otsu,K., Nakayama,H., Hikoso,S., Takeda,T.,
            Gramolini,A.O., Trivieri,M.G., Oudit,G.Y., Morita,T., Kusakari,Y.,
            Hirano,S., Hongo,K., Hirotani,S., Yamaguchi,O., Peterson,A.,
            Backx,P.H., Kurihara,S., Hori,M. and MacLennan,D.H.
  TITLE     Cardiac-specific overexpression of sarcolipin inhibits
            sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and
            impairs cardiac function in mice
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9199-9204 (2004)
   PUBMED   15201433
  REMARK    GeneRIF: SLN overexpression inhibits SERCA2a through stabilization
            of SERCA2a-phospholamban interaction in the absence of PLN.
REFERENCE   10 (residues 1 to 31)
  AUTHORS   Minamisawa,S., Wang,Y., Chen,J., Ishikawa,Y., Chien,K.R. and
            Matsuoka,R.
  TITLE     Atrial chamber-specific expression of sarcolipin is regulated
            during development and hypertrophic remodeling
  JOURNAL   J Biol Chem 278 (11), 9570-9575 (2003)
   PUBMED   12645548
  REMARK    GeneRIF: sarcolipin is likely to be an atrial chamber-specific
            regulator of Ca2+ cycling in heart
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008896.1, BC028496.1 and
            CA460968.1.
            
            Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane
            proteins that catalyze the ATP-dependent transport of Ca(2+) from
            the cytosol into the lumen of the sarcoplasmic reticulum in muscle
            cells. This gene encodes a small proteolipid that regulates several
            sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein
            interacts with Ca(2+)-ATPases and reduces the accumulation of
            Ca(2+) in the sarcoplasmic reticulum without affecting the rate of
            ATP hydrolysis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA460968.1, CB596554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..31
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.24 cM"
     Protein         1..31
                     /product="sarcolipin"
                     /calculated_mol_wt=3676
     Region          2..31
                     /region_name="Sarcolipin"
                     /note="Sarcolipin bioactive peptide and similar proteins;
                     cd20253"
                     /db_xref="CDD:380751"
     Site            8..26
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQD6.1)"
     CDS             1..31
                     /gene="Sln"
                     /gene_synonym="2310045A07Rik"
                     /coded_by="NM_025540.2:144..239"
                     /db_xref="CCDS:CCDS40640.1"
                     /db_xref="GeneID:66402"
                     /db_xref="MGI:MGI:1913652"
ORIGIN      
        1 merstqelfi nftvvlitvl lmwllvrsyq y
//
LOCUS       NP_032986                403 aa            linear   ROD 27-AUG-2025
DEFINITION  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and
            dual-specificity protein phosphatase PTEN [Mus musculus].
ACCESSION   NP_032986
VERSION     NP_032986.1
DBSOURCE    REFSEQ: accession NM_008960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Friedman,C.A., Saha,A., Clark,R., Wilder,C., Wright,J. and
            DiGiovanni,J.
  TITLE     Synergistic Inhibition of Prostate Cancer Progression in Mice With
            a Combination of Curcumin and Ursolic Acid in the Diet
  JOURNAL   Mol Carcinog 64 (9), 1487-1499 (2025)
   PUBMED   40618394
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Xiao,H., Shiu,J., Chen,C.F., Wu,J., Zhou,P., Telang,S.S.,
            Ruiz-Vega,R., Edwards,R.A., Nie,Q., Lander,A.D. and Ganesan,A.K.
  TITLE     Uncovering minimal pathways in melanoma initiation
  JOURNAL   Nat Commun 16 (1), 5369 (2025)
   PUBMED   40571713
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Lin,C., Pulliam,T.L., Han,J.J., Xu,J., Recio,C.V., Wilkenfeld,S.R.,
            Shi,Y., Kushwaha,M., Bench,S., Ruiz,E., Senthilkumar,S., Dileep,J.,
            Shepherd,P.D.A., Navone,N.M., Klekers,A.R., Whitley,E.M.,
            Ittmann,M.M., Eberlin,L.S., Wang,W. and Frigo,D.E.
  TITLE     Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes
            castration-resistant prostate cancer
  JOURNAL   Cell Rep 44 (6), 115792 (2025)
   PUBMED   40483692
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Yucebas,K., Ko,S., Zhou,J., Hamel,E.M., Hackworth,M.G., Diaz
            Miranda,E.A., Carpenter,H.S., Hunter,M.I., Khan,O.M., Weissman,I.L.
            and Jin,S.
  TITLE     Immunotherapy of endometrial cancer via CD47 blockade-mediated
            macrophage phagocytosis
  JOURNAL   PNAS Nexus 4 (5), pgaf143 (2025)
   PUBMED   40371397
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 403)
  AUTHORS   Suzuki,A., de la Pompa,J.L., Stambolic,V., Elia,A.J., Sasaki,T.,
            del Barco Barrantes,I., Ho,A., Wakeham,A., Itie,A., Khoo,W.,
            Fukumoto,M. and Mak,T.W.
  TITLE     High cancer susceptibility and embryonic lethality associated with
            mutation of the PTEN tumor suppressor gene in mice
  JOURNAL   Curr Biol 8 (21), 1169-1178 (1998)
   PUBMED   9799734
REFERENCE   7  (residues 1 to 403)
  AUTHORS   Stambolic,V., Suzuki,A., de la Pompa,J.L., Brothers,G.M.,
            Mirtsos,C., Sasaki,T., Ruland,J., Penninger,J.M., Siderovski,D.P.
            and Mak,T.W.
  TITLE     Negative regulation of PKB/Akt-dependent cell survival by the tumor
            suppressor PTEN
  JOURNAL   Cell 95 (1), 29-39 (1998)
   PUBMED   9778245
REFERENCE   8  (residues 1 to 403)
  AUTHORS   Di Cristofano,A., Pesce,B., Cordon-Cardo,C. and Pandolfi,P.P.
  TITLE     Pten is essential for embryonic development and tumour suppression
  JOURNAL   Nat Genet 19 (4), 348-355 (1998)
   PUBMED   9697695
REFERENCE   9  (residues 1 to 403)
  AUTHORS   Hansen,G.M. and Justice,M.J.
  TITLE     Pten, a candidate tumor suppressor gene, maps to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (1), 88-90 (1998)
   PUBMED   9434957
REFERENCE   10 (residues 1 to 403)
  AUTHORS   Steck,P.A., Pershouse,M.A., Jasser,S.A., Yung,W.K., Lin,H.,
            Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T.,
            Frye,C., Hu,R., Swedlund,B., Teng,D.H. and Tavtigian,S.V.
  TITLE     Identification of a candidate tumour suppressor gene, MMAC1, at
            chromosome 10q23.3 that is mutated in multiple advanced cancers
  JOURNAL   Nat Genet 15 (4), 356-362 (1997)
   PUBMED   9090379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U92437.1, AK138025.1,
            CK616227.1 and BU701098.1.
            
            Summary: This gene encodes a phosphatase with dual activity against
            phospholipids and proteins, and acts as a tumor-suppressor. The
            protein contains four structural domains, a PIP2-binding domain, a
            catalytic tensin-type phosphatase domain, a C2 tensin-type domain
            and a PDZ-binding domain. The protein belongs to the protein
            tyrosine phosphatase family. Deletion of this gene in mice
            contribute to tumorigenesis in multiple tissues. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076980.1, AK088717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 28.14 cM"
     Protein         1..403
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     3-phosphatase and dual-specificity protein phosphatase
                     PTEN"
                     /EC_number="3.1.3.67"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="mutated in multiple advanced cancers 1;
                     mitochondrial PTENalpha; PTENepsilon; inositol
                     polyphosphate 3-phosphatase"
                     /calculated_mol_wt=47021
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          24..181
                     /region_name="PTP_PTEN"
                     /note="protein tyrosine phosphatase-like catalytic domain
                     of phosphatase and tensin homolog; cd14509"
                     /db_xref="CDD:350359"
     Region          188..349
                     /region_name="PTEN_C2"
                     /note="C2 domain of PTEN tumour-suppressor protein;
                     pfam10409"
                     /db_xref="CDD:463081"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by FRK.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          338..348
                     /region_name="Required for interaction with NOP53.
                     /evidence=ECO:0000250|UniProtKB:P60484"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Region          352..403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta and PLK3.
                     /evidence=ECO:0000269|PubMed:20940307; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2 and PLK3.
                     /evidence=ECO:0000269|PubMed:20940307; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            385
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          401..403
                     /region_name="PDZ domain-binding.
                     /evidence=ECO:0000305|PubMed:33428810"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Site            401
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     CDS             1..403
                     /gene="Pten"
                     /gene_synonym="2310035O07Rik; A130070J02Rik;
                     B430203M17Rik; MMAC1; PTENbeta; TEP1"
                     /coded_by="NM_008960.2:869..2080"
                     /db_xref="CCDS:CCDS29753.1"
                     /db_xref="GeneID:19211"
                     /db_xref="MGI:MGI:109583"
ORIGIN      
        1 mtaiikeivs rnkrryqedg fdldltyiyp niiamgfpae rlegvyrnni ddvvrfldsk
       61 hknhykiynl caerhydtak fncrvaqypf edhnppqlel ikpfcedldq wlseddnhva
      121 aihckagkgr tgvmicayll hrgkflkaqe aldfygevrt rdkkgvtips qrryvyyysy
      181 llknhldyrp vallfhkmmf etipmfsggt cnpqfvvcql kvkiyssnsg ptrredkfmy
      241 fefpqplpvc gdikveffhk qnkmlkkdkm fhfwvntffi pgpeetsekv engslcdqei
      301 dsicsierad ndkeylvltl tkndldkank dkanryfspn fkvklyftkt veepsnpeas
      361 sstsvtpdvs dnepdhyrys dttdsdpene pfdedqhsqi tkv
//
LOCUS       NP_001318039             570 aa            linear   ROD 27-AUG-2025
DEFINITION  CD166 antigen isoform 2 precursor [Mus musculus].
ACCESSION   NP_001318039 XP_006521777
VERSION     NP_001318039.1
DBSOURCE    REFSEQ: accession NM_001331110.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 570)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 570)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 570)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 570)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   5  (residues 1 to 570)
  AUTHORS   Baek,S.M., Kim,M.N., Kim,E.G., Lee,Y.J., Park,C.H., Kim,M.J.,
            Kim,K.W. and Sohn,M.H.
  TITLE     Activated Leukocyte Cell Adhesion Molecule Regulates the Expression
            of Interleukin-33 in RSV Induced Airway Inflammation by Regulating
            MAPK Signaling Pathways
  JOURNAL   Lung 202 (2), 127-137 (2024)
   PUBMED   38502305
  REMARK    GeneRIF: Activated Leukocyte Cell Adhesion Molecule Regulates the
            Expression of Interleukin-33 in RSV Induced Airway Inflammation by
            Regulating MAPK Signaling Pathways.
REFERENCE   6  (residues 1 to 570)
  AUTHORS   Fraboulet,S., Schmidt-Petri,T., Dhouailly,D. and Pourquie,O.
  TITLE     Expression of DM-GRASP/BEN in the developing mouse spinal cord and
            various epithelia
  JOURNAL   Mech Dev 95 (1-2), 221-224 (2000)
   PUBMED   10906467
REFERENCE   7  (residues 1 to 570)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   8  (residues 1 to 570)
  AUTHORS   Sekine-Aizawa,Y., Omori,A. and Fujita,S.C.
  TITLE     MuSC, a novel member of the immunoglobulin superfamily, is
            expressed in neurons of a subset of cranial sensory ganglia in the
            mouse embryo
  JOURNAL   Eur J Neurosci 10 (9), 2810-2824 (1998)
   PUBMED   9758151
REFERENCE   9  (residues 1 to 570)
  AUTHORS   Bowen,M.A., Bajorath,J., D'Egidio,M., Whitney,G.S., Palmer,D.,
            Kobarg,J., Starling,G.C., Siadak,A.W. and Aruffo,A.
  TITLE     Characterization of mouse ALCAM (CD166): the CD6-binding domain is
            conserved in different homologs and mediates cross-species binding
  JOURNAL   Eur J Immunol 27 (6), 1469-1478 (1997)
   PUBMED   9209500
REFERENCE   10 (residues 1 to 570)
  AUTHORS   Kanki,J.P., Chang,S. and Kuwada,J.Y.
  TITLE     The molecular cloning and characterization of potential chick
            DM-GRASP homologs in zebrafish and mouse
  JOURNAL   J Neurobiol 25 (7), 831-845 (1994)
   PUBMED   8089660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154383.2, AC117780.5 and BE654940.1.
            
            On Sep 8, 2016 this sequence version replaced XP_006521777.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 32.88 cM"
     Protein         1..570
                     /product="CD166 antigen isoform 2 precursor"
                     /note="CD166 antigen"
                     /calculated_mol_wt=60898
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     Region          29..117
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          39..43
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          55..59
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          96..100
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          137..231
                     /region_name="C2-set_2"
                     /note="CD80-like C2-set immunoglobulin domain; pfam08205"
                     /db_xref="CDD:400489"
     Region          151..157
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          167..171
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          203..207
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          217..222
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          255..329
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          296..300
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          310..315
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          339..393
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          415..489
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..570
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /coded_by="NM_001331110.1:617..2329"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS84242.1"
                     /db_xref="GeneID:11658"
                     /db_xref="MGI:MGI:1313266"
ORIGIN      
        1 maskvspscr lvfcllisaa vlrpglgwyt vnsaygdtiv mpcrldvpqn lmfgkwkyek
       61 pdgspvfiaf rsstkksvqy ddvpeykdrl slsenytlsi anakisdekr fvcmlvtedn
      121 vfeaptlvkv fkqpskpeiv nkapfletdq lkklgdcisr dsypdgnitw yrngkvlqpv
      181 egevailfkk eidpgtqlyt vtssleyktt rsdiqmpftc svtyygpsgq ktiyseqeif
      241 diyypteqvt iqvlppknai kegdnitlqc lgngnpppee fmfylpgqpe girssntytl
      301 tdvrrnatgd ykcslidkrn maasttitvh yldlslnpsg evtkqigdtl pvsctisasr
      361 natvvwmkdn irlrsspsfs slhyqdagny vcetalqeve glkkresltl ivegkpqikm
      421 tkktdpsgls ktiichvegf pkpaihwtit gsgsvinqte espyingryy skiiispeen
      481 vtltctaenq lertvnslnv sanenrekvn dqaklivgiv vglllaalva gvvywlymkk
      541 sktaskhvnk dlgnmeenkk leennhktea
//
LOCUS       NP_001346202             934 aa            linear   ROD 27-AUG-2025
DEFINITION  netrin receptor UNC5B isoform 2 precursor [Mus musculus].
ACCESSION   NP_001346202 XP_006513091
VERSION     NP_001346202.1
DBSOURCE    REFSEQ: accession NM_001359273.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 934)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 934)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 934)
  AUTHORS   Zhao,R., Ren,B., Xiao,Y., Tian,J., Zou,Y., Wei,J., Qi,Y., Hu,A.,
            Xie,X., Huang,Z.J., Shu,Y., He,M., Lu,J. and Tai,Y.
  TITLE     Axo-axonic synaptic input drives homeostatic plasticity by tuning
            the axon initial segment structurally and functionally
  JOURNAL   Sci Adv 10 (31), eadk4331 (2024)
   PUBMED   39093969
REFERENCE   4  (residues 1 to 934)
  AUTHORS   Raudales,R., Kim,G., Kelly,S.M., Hatfield,J., Guan,W., Zhao,S.,
            Paul,A., Qian,Y., Li,B. and Huang,Z.J.
  TITLE     Specific and comprehensive genetic targeting reveals brain-wide
            distribution and synaptic input patterns of GABAergic axo-axonic
            interneurons
  JOURNAL   Elife 13, 93481 (2024)
   PUBMED   39012795
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 934)
  AUTHORS   Raza,Q., Nadeem,T., Youn,S.W., Swaminathan,B., Gupta,A., Sargis,T.,
            Du,J., Cuervo,H., Eichmann,A., Ackerman,S.L., Naiche,L.A. and
            Kitajewski,J.
  TITLE     Notch signaling regulates UNC5B to suppress endothelial
            proliferation, migration, junction activity, and retinal plexus
            branching
  JOURNAL   Sci Rep 14 (1), 13603 (2024)
   PUBMED   38866944
  REMARK    GeneRIF: Notch signaling regulates UNC5B to suppress endothelial
            proliferation, migration, junction activity, and retinal plexus
            branching.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 934)
  AUTHORS   Alcantara,S., Ruiz,M., De Castro,F., Soriano,E. and Sotelo,C.
  TITLE     Netrin 1 acts as an attractive or as a repulsive cue for distinct
            migrating neurons during the development of the cerebellar system
  JOURNAL   Development 127 (7), 1359-1372 (2000)
   PUBMED   10704383
REFERENCE   7  (residues 1 to 934)
  AUTHORS   Bloch-Gallego,E., Ezan,F., Tessier-Lavigne,M. and Sotelo,C.
  TITLE     Floor plate and netrin-1 are involved in the migration and survival
            of inferior olivary neurons
  JOURNAL   J Neurosci 19 (11), 4407-4420 (1999)
   PUBMED   10341242
REFERENCE   8  (residues 1 to 934)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 934)
  AUTHORS   Leonardo,E.D., Hinck,L., Masu,M., Keino-Masu,K., Ackerman,S.L. and
            Tessier-Lavigne,M.
  TITLE     Vertebrate homologues of C. elegans UNC-5 are candidate netrin
            receptors
  JOURNAL   Nature 386 (6627), 833-838 (1997)
   PUBMED   9126742
REFERENCE   10 (residues 1 to 934)
  AUTHORS   Doherty,T.M., Kastelein,R., Menon,S., Andrade,S. and Coffman,R.L.
  TITLE     Modulation of murine macrophage function by IL-13
  JOURNAL   J Immunol 151 (12), 7151-7160 (1993)
   PUBMED   7903102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018177.1, BC048162.1, AK147603.1 and AW488068.1.
            
            On Dec 30, 2017 this sequence version replaced XP_006513091.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 31.52 cM"
     Protein         1..934
                     /product="netrin receptor UNC5B isoform 2 precursor"
                     /note="netrin receptor UNC5B; protein unc-5 homolog B;
                     protein unc-5 homolog 2; unc5 homolog 2"
                     /calculated_mol_wt=99659
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2811
     Region          157..243
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          170..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          184..188
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            222
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          236..239
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          249..300
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          305..353
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Site            347
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Site            367..387
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Site            401..402
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-3.
                     /evidence=ECO:0000250|UniProtKB:O08722; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          530..633
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O08747; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          678..827
                     /region_name="UPA domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          680..819
                     /region_name="UPA"
                     /note="UPA domain; pfam17217"
                     /db_xref="CDD:465384"
     Region          696..714
                     /region_name="Interaction with DCC.
                     /evidence=ECO:0000250|UniProtKB:O08722"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          847..930
                     /region_name="Death_UNC5B"
                     /note="Death domain found in Uncoordinated-5B; cd08802"
                     /db_xref="CDD:176780"
     Site            order(880..881,883..884,894,897..898,901..902)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:176780"
     CDS             1..934
                     /gene="Unc5b"
                     /gene_synonym="6330415E02Rik; A630020F16; D10Bwg0792e;
                     Unc5h2"
                     /coded_by="NM_001359273.1:417..3221"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS88011.1"
                     /db_xref="GeneID:107449"
                     /db_xref="MGI:MGI:894703"
ORIGIN      
        1 mrarsgvrsa lllalllcwd ptpslagvds agqvlpdsyp sapaeqlpyf llepqdayiv
       61 knkpvelhcr afpatqiyfk cngewvsqnd hvtqesldea tglrvrevqi evsrqqveel
      121 fgledywcqc vawsssgttk srrayiriay lrknfdqepl akevpldhev llqcrppegv
      181 pvaevewlkn edvidpaqdt nflltidhnl iirqarlsdt anytcvakni vakrrsttat
      241 vivyvnggws swaewspcsn rcgrgwqkrt rtctnpapln ggafcegqaf qktacttvcp
      301 vdgawtewsk wsacstecah wrsrecmapp pqnggrdcsg tlldsknctd glcvltlets
      361 gdvalyaglv vavfvvvavl mavgvivyrr ncrdfdtdit dssaaltggf hpvnfktarp
      421 nnpqllhpsa ppdltasagi yrgpvyalqd sadkipmtns plldplpslk ikvynsstig
      481 sgsgladgad llgvlppgty pgdfsrdthf lhlrsaslgs qhllglprdp sssvsgtfgc
      541 lggrlslpgt gvsllvpnga ipqgkfydly lhinkaestl plsegsqtvl spsvtcgptg
      601 lllcrpvvlt vphcaeviag dwifqlktqa hqghweevvt ldeetlntpc ycqleaksch
      661 illdqlgtyv fmgesysrsa vkrlqlaifa palctsleys lrvycledtp valkevlele
      721 rtlggylvee pkpllfkdsy hnlrlslhdi phahwrskll akyqeipfyh vwngsqralh
      781 ctftlerhsl asteftckvc vrqvegegqi fqlhttlaet pagsldalcs apgnaittql
      841 gpyafkipls irqkicssld apnsrgndwr llaqklsmdr ylnyfatkas ptgvildlwe
      901 arqqddgdln slasaleemg ksemlvamat dgdc
//
LOCUS       NP_001074396             487 aa            linear   ROD 27-AUG-2025
DEFINITION  recombining binding protein suppressor of hairless isoform 2 [Mus
            musculus].
ACCESSION   NP_001074396
VERSION     NP_001074396.1
DBSOURCE    REFSEQ: accession NM_001080927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 487)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   2  (residues 1 to 487)
  AUTHORS   Chen,K.Y., Kibayashi,T., Giguelay,A., Hata,M., Nakajima,S.,
            Mikami,N., Takeshima,Y., Ichiyama,K., Omiya,R., Ludwig,L.S.,
            Hattori,K. and Sakaguchi,S.
  TITLE     Genome-wide CRISPR screen in human T cells reveals regulators of
            FOXP3
  JOURNAL   Nature 642 (8066), 191-200 (2025)
   PUBMED   40140585
  REMARK    Erratum:[Nature. 2025 Jul;643(8074):E25. doi:
            10.1038/s41586-025-09356-6. PMID: 40640568]
REFERENCE   3  (residues 1 to 487)
  AUTHORS   O'Hara,J., Dakle,P., Nguyen,M.L.T., Barugahare,A., Bennett,T.J.,
            Udupa,V.A., Murray,N., Schlegel,G., Kapouleas,C., Li,J.,
            Turner,S.J. and Russ,B.E.
  TITLE     Notch dependent chromatin remodeling enables Gata3 binding and
            drives lineage specific CD8+ T cell function
  JOURNAL   Immunol Cell Biol 103 (4), 365-382 (2025)
   PUBMED   40012375
REFERENCE   4  (residues 1 to 487)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   5  (residues 1 to 487)
  AUTHORS   Nakisli,S., Fanelli,K., LaComb,J., Arnold,L.J. and Nielsen,C.M.
  TITLE     CNS resident macrophages exhibit region-specific states and
            immunogenic responses during Rbpj-deficient brain arteriovenous
            malformation
  JOURNAL   Sci Rep 15 (1), 3932 (2025)
   PUBMED   39890825
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 487)
  AUTHORS   Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and
            Israel,A.
  TITLE     Signalling downstream of activated mammalian Notch
  JOURNAL   Nature 377 (6547), 355-358 (1995)
   PUBMED   7566092
REFERENCE   7  (residues 1 to 487)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
REFERENCE   8  (residues 1 to 487)
  AUTHORS   Hamaguchi,Y., Mastunami,N., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     Cloning and characterization of a protein binding to the J kappa
            recombination signal sequence of immunoglobulin genes
  JOURNAL   Adv Exp Med Biol 292, 177-186 (1991)
   PUBMED   1950768
REFERENCE   9  (residues 1 to 487)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
REFERENCE   10 (residues 1 to 487)
  AUTHORS   Siminovitch,K.A., Moore,M.W., Durdik,J. and Selsing,E.
  TITLE     The human kappa deleting element and the mouse recombining segment
            share DNA sequence homology
  JOURNAL   Nucleic Acids Res 15 (6), 2699-2705 (1987)
   PUBMED   3104881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084054.12, BY716845.1, AK080359.1, AK028363.1 and AK132145.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145187.1, BC051387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.37 cM"
     Protein         1..487
                     /product="recombining binding protein suppressor of
                     hairless isoform 2"
                     /note="recombining binding protein suppressor of hairless;
                     J-kappa recombination signal binding protein; Jkappa
                     recombination signal binding protein"
                     /calculated_mol_wt=54216
     Region          35..165
                     /region_name="LAG1-DNAbind"
                     /note="LAG1, DNA binding; pfam09271"
                     /db_xref="CDD:462735"
     Region          193..315
                     /region_name="BTD"
                     /note="Beta-trefoil DNA-binding domain; pfam09270"
                     /db_xref="CDD:462734"
     Region          337..433
                     /region_name="IPT_RBP-Jkappa"
                     /note="IPT domain of the recombination signal Jkappa
                     binding protein (RBP-Jkappa). RBP-J kappa, was initially
                     considered to be involved in V(D)J recombination because
                     of its DNA binding specificity and structural similarity
                     to site-specific recombinases known...; cd01176"
                     /db_xref="CDD:238581"
     CDS             1..487
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /coded_by="NM_001080927.2:220..1683"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS51504.1"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
ORIGIN      
        1 mapvvtgkfg erpppkrltr eamrnylker gdqtvlilha kvaqksygne krffcpppcv
       61 ylmgsgwkkk keqmerdgcs eqesqpcafi gignsdqemq qlnlegknyc taktlyisds
      121 dkrkhfmlsv kmfygnsddi gvflskrikv iskpskkkqs lknadlcias gtkvalfnrl
      181 rsqtvstryl hveggnfhas sqqwgafyih lldddesege eftvrdgyih ygqtvklvcs
      241 vtgmalprli irkvdkqtal ldaddpvsql hkcafylkdt ermylclsqe riiqfqatpc
      301 pkeqnkemin dgaswtiist dkaeytfyeg mgpvlapvtp vpvveslqln gggdvamlel
      361 tgqnftpnlr vwfgdveaet myrcgesmlc vvpdisafre gwrwvrqpvq vpvtlvrndg
      421 viystsltft ytpepgprph csaagailra nssqvpsnes ntnsegnytn astnstsvts
      481 statvvs
//
LOCUS       NP_001351549             730 aa            linear   ROD 27-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform 3 [Mus musculus].
ACCESSION   NP_001351549 XP_006515482
VERSION     NP_001351549.1
DBSOURCE    REFSEQ: accession NM_001364620.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 730)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 730)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 730)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   4  (residues 1 to 730)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   5  (residues 1 to 730)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 730)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (residues 1 to 730)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 730)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (residues 1 to 730)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (residues 1 to 730)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6 and AB794101.1.
            
            On Jun 26, 2018 this sequence version replaced XP_006515482.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB794101.1, SRR11927937.3440711.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     Protein         1..730
                     /product="metastasis-associated protein MTA1 isoform 3"
                     /note="metastasis-associated protein MTA1"
                     /calculated_mol_wt=82257
     Region          3..188
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          167..219
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          287..332
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(288,318..319,321..322,324..326,328..330)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          388..441
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          464..541
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..730
                     /gene="Mta1"
                     /coded_by="NM_001364620.1:141..2333"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd issslialad
       61 khatlsvcyr agpgadtgee geveeevenp emvdlpeklk hqlrhrelfl srqleslpat
      121 hirgkcsvtl lneteslksy leredfffys lvydpqqktl ladkgeirvg nryqaditdl
      181 lkegeedgrd qskletkvwe ahnplvdkqi dqflvvarsv gtfaraldcs ssvrqpslhm
      241 saaaasrdit lfhamdtlhk niydiskais alvpqggpvl crdemeewsa seanlfeeal
      301 ekygkdftdi qqdflpwksl tsiieyyymw kttdryvqqk rlkaaeaesk lkqvyipnyn
      361 kpnpnqisas svkatvvngt gtpgqspgag racescyttq syqwyswgpp nmqcrlcasc
      421 wtywkkyggl kmptrldger pgpnrnnmsp hgiparssgs pkfamktrqa fylhttkltr
      481 iarrlcreil rpwhaarhpy mpinsaaika ectarlpeas qsplvlkqvv rkpleavlry
      541 lethprppkp dpvkssssvl ssltpaksap vinngsptil gkrsyeqhng vdvdvfspsl
      601 scswalpgnm kkrllmpsrg lanhgqtrhm gpsrnlllng ksyptkvrli rggslppvkr
      661 rrmnwidapd dvfymateet rkirkllsss etkraarrpy kpialrqsqa lplrppppap
      721 vndepivied
//
LOCUS       NP_031508                323 aa            linear   ROD 27-AUG-2025
DEFINITION  arginase-1 [Mus musculus].
ACCESSION   NP_031508
VERSION     NP_031508.1
DBSOURCE    REFSEQ: accession NM_007482.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 323)
  AUTHORS   Heuser,S.K., Li,J., Li,Z., LoBue,A., Heard,K., Hocks,J.,
            Suvorava,T., Cadeddu,R.P., Strupp,C., Dunaway,L., Zhuge,Z.,
            Gelhaus,S.L., Heinen,A., Germing,U., Feelisch,M., Carlstrom,M.,
            Isakson,B., Kelm,M., Lundberg,J.O. and Cortese-Krott,M.M.
  TITLE     Divergent roles of red cell arginase in humans and mice: RBC Arg1
            KO mice show preserved systemic l-arginine bioavailability and
            infarct size in vivo
  JOURNAL   Redox Biol 86, 103768 (2025)
   PUBMED   40729962
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 323)
  AUTHORS   Nater,M., Brugger,M., Cecconi,V., Pereira,P., Forni,G., Koksal,H.,
            Dimakou,D., Herbst,M., Calvanese,A.L., Lucchiari,G., Schneider,C.,
            Valenta,T. and van den Broek,M.
  TITLE     Hepatic iNKT cells facilitate colorectal cancer metastasis by
            inducing a fibrotic niche in the liver
  JOURNAL   iScience 28 (5), 112364 (2025)
   PUBMED   40292307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 323)
  AUTHORS   Feng,X., Andersson,T., Fluchter,P., Gschwend,J., Berest,I.,
            Muff,J.L., Lechner,A., Gondrand,A., Westermann,P., Brander,N.,
            Carchidi,D., De Tenorio,J.C., Pan,T., Boehm,U., Klose,C.S.N.,
            Artis,D., Messner,C.B., Leinders-Zufall,T., Zufall,F. and
            Schneider,C.
  TITLE     Tuft cell IL-17RB restrains IL-25 bioavailability and reveals
            context-dependent ILC2 hypoproliferation
  JOURNAL   Nat Immunol 26 (4), 567-581 (2025)
   PUBMED   40074948
REFERENCE   4  (residues 1 to 323)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   5  (residues 1 to 323)
  AUTHORS   Braun,L.M., Giesler,S., Andrieux,G., Riemer,R., Talvard-Balland,N.,
            Duquesne,S., Ruckert,T., Unger,S., Kreutmair,S., Zwick,M.,
            Follo,M., Hartmann,A., Osswald,N., Melchinger,W., Chapman,S.,
            Hutchinson,J.A., Haferkamp,S., Torster,L., Kott,J., Gebhardt,C.,
            Hellwig,D., Karantzelis,N., Wallrabenstein,T., Lowinus,T.,
            Yucel,M., Brehm,N., Rawluk,J., Pfeifer,D., Bronsert,P., Rogg,M.,
            Mattern,S., Heikenwalder,M., Fusco,S., Malek,N.P., Singer,S.,
            Schmitt-Graeff,A., Ceteci,F., Greten,F.R., Blazar,B.R.,
            Boerries,M., Kohler,N., Duyster,J., Ihorst,G., Lassmann,S.,
            Keye,P., Minguet,S., Schadendorf,D., Ugurel,S.,
            Rafei-Shamsabadi,D., Thimme,R., Hasselblatt,P., Bengsch,B.,
            Schell,C., Pearce,E.L., Meiss,F., Becher,B., Funke-Lorenz,C.,
            Placke,J.M., Apostolova,P. and Zeiser,R.
  TITLE     Adiponectin reduces immune checkpoint inhibitor-induced
            inflammation without blocking anti-tumor immunity
  JOURNAL   Cancer Cell 43 (2), 269-291 (2025)
   PUBMED   39933899
REFERENCE   6  (residues 1 to 323)
  AUTHORS   Louis,C.A., Mody,V., Henry,W.L. Jr., Reichner,J.S. and Albina,J.E.
  TITLE     Regulation of arginase isoforms I and II by IL-4 in cultured murine
            peritoneal macrophages
  JOURNAL   Am J Physiol 276 (1), R237-R242 (1999)
   PUBMED   9887201
REFERENCE   7  (residues 1 to 323)
  AUTHORS   Iyer,R.K., Bando,J.M., Jenkinson,C.P., Vockley,J.G., Kim,P.S.,
            Kern,R.M., Cederbaum,S.D. and Grody,W.W.
  TITLE     Cloning and characterization of the mouse and rat type II arginase
            genes
  JOURNAL   Mol Genet Metab 63 (3), 168-175 (1998)
   PUBMED   9608538
REFERENCE   8  (residues 1 to 323)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
REFERENCE   9  (residues 1 to 323)
  AUTHORS   Hashimoto,C., Masuda,H., Ayaki,M., Suzuki,Y., Uenaka,A., Seya,T.,
            Miyoshi,J., Takahashi,K. and Inui,Y.
  TITLE     Molecular cloning and sequence analysis of the cDNA for the mouse
            counterpart to adult hamster liver purified growth inhibitory
            factor
  JOURNAL   Biochim Biophys Acta 1355 (3), 205-208 (1997)
   PUBMED   9060991
REFERENCE   10 (residues 1 to 323)
  AUTHORS   Ohtake,A., Takayanagi,M., Yamamoto,S., Nakajima,H. and Mori,M.
  TITLE     Ornithine transcarbamylase deficiency in spf and spf-ash mice:
            genes, mRNAs and mRNA precursors
  JOURNAL   Biochem Biophys Res Commun 146 (3), 1064-1070 (1987)
   PUBMED   3039990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB947842.1, AK149471.1 and U88541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149471.1, BC013341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     Protein         1..323
                     /product="arginase-1"
                     /EC_number="3.5.3.1"
                     /note="arginase I; type I arginase; liver-type arginase;
                     arginase 1, liver"
                     /calculated_mol_wt=34677
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61176.1)"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     Region          9..303
                     /region_name="Arginase-like"
                     /note="Arginase types I and II and arginase-like family;
                     cd11587"
                     /db_xref="CDD:212536"
     Site            order(14,17,25..26,29,32,49,52..53,242,246,250,254..255,
                     291,294..295,298,302)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:212536"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P05089; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     Site            order(101,124,126,128,141,232,234,277)
                     /site_type="active"
                     /db_xref="CDD:212536"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     Site            217
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P05089; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     Site            281
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61176.1)"
     CDS             1..323
                     /gene="Arg1"
                     /gene_synonym="AI; Arg-1; PGIF"
                     /coded_by="NM_007482.3:103..1074"
                     /db_xref="CCDS:CCDS48523.1"
                     /db_xref="GeneID:11846"
                     /db_xref="MGI:MGI:88070"
ORIGIN      
        1 msskpkslei igapfskgqp rggvekgpaa lrkagllekl keteydvrdh gdlafvdvpn
       61 dssfqivknp rsvgkaneel agvvaevqkn grvsvvlggd hslavgsisg harvhpdlcv
      121 iwvdahtdin tplttssgnl hgqpvsfllk elkgkfpdvp gfswvtpcis akdivyiglr
      181 dvdpgehyii ktlgikyfsm tevdklgigk vmeetfsyll grkkrpihls fdvdgldpaf
      241 tpatgtpvlg glsyreglyi teeiyktgll sgldimevnp tlgktaeevk stvntavalt
      301 lacfgtqreg nhkpgtdylk ppk
//
LOCUS       NP_036150                375 aa            linear   ROD 27-AUG-2025
DEFINITION  forkhead box protein L2 [Mus musculus].
ACCESSION   NP_036150 XP_981696
VERSION     NP_036150.1
DBSOURCE    REFSEQ: accession NM_012020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   2  (residues 1 to 375)
  AUTHORS   Dupont,S.M., Garcia-Moreno,A., O'Neil,E.V. and Capel,B.C.
  TITLE     KDM6B is a conserved activator at the top of the male sex
            determination pathway
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40406982
REFERENCE   3  (residues 1 to 375)
  AUTHORS   Sheridan,D., Chakravarty,P., Golan,G., Shiakola,Y., Olsen,J.,
            Burnett,E., Galichet,C., Fiordelisio,T., Mollard,P., Melamed,P.,
            Lovell-Badge,R. and Rizzoti,K.
  TITLE     Gonadotrophs have a dual origin, with most derived from early
            postnatal pituitary stem cells
  JOURNAL   Nat Commun 16 (1), 4280 (2025)
   PUBMED   40399281
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 375)
  AUTHORS   Li,J., Welte,T., Calzoncinth,K., Vuttaradhi,V.K., Brodsky,A.L.,
            Wong,K.K., Sebastian,M.M., Lawson,B., Kingsley,C.V. and
            Hillman,R.T.
  TITLE     An inducible FOXL2-dependent mouse model of ovarian adult type
            granulosa cell tumor
  JOURNAL   Gynecol Oncol 194, 125-130 (2025)
   PUBMED   40221170
REFERENCE   5  (residues 1 to 375)
  AUTHORS   Park,C.J., Oh,J.E., Lin,P., Zhou,S., Bunnell,M., Bikorimana,E.,
            Spinella,M.J., Lim,H.J. and Ko,C.J.
  TITLE     A Dynamic Shift in Estrogen Receptor Expression During Granulosa
            Cell Differentiation in the Ovary
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39834231
REFERENCE   6  (residues 1 to 375)
  AUTHORS   Ellsworth,B.S., Burns,A.T., Escudero,K.W., Duval,D.L., Nelson,S.E.
            and Clay,C.M.
  TITLE     The gonadotropin releasing hormone (GnRH) receptor activating
            sequence (GRAS) is a composite regulatory element that interacts
            with multiple classes of transcription factors including Smads,
            AP-1 and a forkhead DNA binding protein
  JOURNAL   Mol Cell Endocrinol 206 (1-2), 93-111 (2003)
   PUBMED   12943993
REFERENCE   7  (residues 1 to 375)
  AUTHORS   Loffler,K.A., Zarkower,D. and Koopman,P.
  TITLE     Etiology of ovarian failure in blepharophimosis ptosis epicanthus
            inversus syndrome: FOXL2 is a conserved, early-acting gene in
            vertebrate ovarian development
  JOURNAL   Endocrinology 144 (7), 3237-3243 (2003)
   PUBMED   12810580
  REMARK    GeneRIF: FOXL2 is a highly conserved early regulator of vertebrate
            ovarian development.
REFERENCE   8  (residues 1 to 375)
  AUTHORS   Cocquet,J., Pailhoux,E., Jaubert,F., Servel,N., Xia,X.,
            Pannetier,M., De Baere,E., Messiaen,L., Cotinot,C., Fellous,M. and
            Veitia,R.A.
  TITLE     Evolution and expression of FOXL2
  JOURNAL   J Med Genet 39 (12), 916-921 (2002)
   PUBMED   12471206
  REMARK    GeneRIF: Molecular evolution and expression of FOXL2
REFERENCE   9  (residues 1 to 375)
  AUTHORS   Crisponi,L., Deiana,M., Loi,A., Chiappe,F., Uda,M., Amati,P.,
            Bisceglia,L., Zelante,L., Nagaraja,R., Porcu,S., Ristaldi,M.S.,
            Marzella,R., Rocchi,M., Nicolino,M., Lienhardt-Roussie,A.,
            Nivelon,A., Verloes,A., Schlessinger,D., Gasparini,P., Bonneau,D.,
            Cao,A. and Pilia,G.
  TITLE     The putative forkhead transcription factor FOXL2 is mutated in
            blepharophimosis/ptosis/epicanthus inversus syndrome
  JOURNAL   Nat Genet 27 (2), 159-166 (2001)
   PUBMED   11175783
REFERENCE   10 (residues 1 to 375)
  AUTHORS   Kioussi,C., O'Connell,S., St-Onge,L., Treier,M., Gleiberman,A.S.,
            Gruss,P. and Rosenfeld,M.G.
  TITLE     Pax6 is essential for establishing ventral-dorsal cell boundaries
            in pituitary gland development
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14378-14382 (1999)
   PUBMED   10588713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120148.13.
            
            On May 4, 2006 this sequence version replaced XP_981696.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC137811.1, SRR7974084.25061.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.41 cM"
     Protein         1..375
                     /product="forkhead box protein L2"
                     /note="putative transcription factor foxl2; pituitary
                     forkhead factor"
                     /calculated_mol_wt=38756
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88470.2)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P58012; propagated from
                     UniProtKB/Swiss-Prot (O88470.2)"
     Region          50..138
                     /region_name="FH_FOXL2"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     L2 (FOXL2) and similar proteins; cd20028"
                     /db_xref="CDD:410802"
     Site            order(55,73..74,77,96..97,99..100,103,110,120..122,124)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410802"
     Region          272..341
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88470.2)"
     CDS             1..375
                     /gene="Foxl2"
                     /gene_synonym="BPES; P-Frk; Pfrk; PINTO"
                     /coded_by="NM_012020.3:220..1347"
                     /db_xref="CCDS:CCDS23430.1"
                     /db_xref="GeneID:26927"
                     /db_xref="MGI:MGI:1349428"
ORIGIN      
        1 mmasypeped tagtllapes gravkeaeas ppspgkgggt tpekpdpaqk ppysyvalia
       61 mairesaekr ltlsgiyqyi iakfpfyekn kkgwqnsirh nlslnecfik vpregggerk
      121 gnywtldpac edmfekgnyr rrrrmkrpfr pppahfqpgk glfgsggaag gcgvpgagad
      181 gygylappky lqsgflnnsw plpqppspmp yascqmaaaa aaaaaaaaaa gpgspgaaav
      241 vkglagpaas ygpysrvqsm alppgvvnsy nglggppaap ppppppphph phphahhlha
      301 aaapppapph hgaaapppgq lspaspataa ppapaptsap glqfacarqp elammhcsyw
      361 dhdsktgalh srldl
//
LOCUS       NP_001317615             110 aa            linear   ROD 27-AUG-2025
DEFINITION  parvalbumin alpha [Mus musculus].
ACCESSION   NP_001317615 XP_006520706
VERSION     NP_001317615.1
DBSOURCE    REFSEQ: accession NM_001330686.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Olinger,E., Schwaller,B., Loffing,J., Gailly,P. and Devuyst,O.
  TITLE     Parvalbumin: calcium and magnesium buffering in the distal nephron
  JOURNAL   Nephrol Dial Transplant 27 (11), 3988-3994 (2012)
   PUBMED   23144069
  REMARK    Review article
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Ritzler,J.M., Sawhney,R., Geurts van Kessel,A.H., Grzeschik,K.H.,
            Schinzel,A. and Berchtold,M.W.
  TITLE     The genes for the highly homologous Ca(2+)-binding proteins
            oncomodulin and parvalbumin are not linked in the human genome
  JOURNAL   Genomics 12 (3), 567-572 (1992)
   PUBMED   1559707
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Schleef,M., Zuhlke,C., Jockusch,H. and Schoffl,F.
  TITLE     The structure of the mouse parvalbumin gene
  JOURNAL   Mamm Genome 3 (4), 217-225 (1992)
   PUBMED   1611216
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Zuhlke,C., Schoffl,F., Jockusch,H., Simon,D. and Guenet,J.L.
  TITLE     cDNA sequence and chromosomal localization of the mouse parvalbumin
            gene, Pva
  JOURNAL   Genet Res 54 (1), 37-43 (1989)
   PUBMED   2572511
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Adolph,S., Berchtold,M.W. and Hameister,H.
  TITLE     Fine localization of genes on distal murine chromosome 15
  JOURNAL   Cytogenet Cell Genet 52 (3-4), 177-179 (1989)
   PUBMED   2630190
REFERENCE   10 (residues 1 to 110)
  AUTHORS   Iwasaki,Y., Ohkubo,A., Kamei,S. and Kosaka,K.
  TITLE     [Serial determination of serum GOT isozyme activities for the
            evaluation of acute hepatic damage (author's transl)]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 75 (1), 34-43 (1978)
   PUBMED   642215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131986.1, DV051867.1 and AI645659.1.
            
            On Sep 1, 2016 this sequence version replaced XP_006520706.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131986.1, AK013561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.93 cM"
     Protein         1..110
                     /product="parvalbumin alpha"
                     /note="alpha-PV; alpha-parvalbumin"
                     /calculated_mol_wt=11799
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000269|PubMed:10036163; propagated from
                     UniProtKB/Swiss-Prot (P32848.3)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02625; propagated from
                     UniProtKB/Swiss-Prot (P32848.3)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02625; propagated from
                     UniProtKB/Swiss-Prot (P32848.3)"
     Region          9..109
                     /region_name="EFh_parvalbumin_alpha"
                     /note="EF-hand, calcium binding motif, found in
                     alpha-parvalbumin; cd16254"
                     /db_xref="CDD:319997"
     Region          9..38
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319997"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02625; propagated from
                     UniProtKB/Swiss-Prot (P32848.3)"
     Region          43..72
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319997"
     Site            order(52,54,56,60,63,91,93,95,102)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319997"
     Region          82..109
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:319997"
     CDS             1..110
                     /gene="Pvalb"
                     /gene_synonym="Parv; PV; Pva"
                     /coded_by="NM_001330686.1:93..425"
                     /db_xref="CCDS:CCDS27609.1"
                     /db_xref="GeneID:19293"
                     /db_xref="MGI:MGI:97821"
ORIGIN      
        1 msmtdvlsae dikkaigafa aadsfdhkkf fqmvglkkkn pdevkkvfhi ldkdksgfie
       61 edelgsilkg fssdardlsa ketktllaag dkdgdgkigv eefstlvaes
//
LOCUS       NP_035771                586 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor protein 63 isoform d [Mus musculus].
ACCESSION   NP_035771
VERSION     NP_035771.1
DBSOURCE    REFSEQ: accession NM_011641.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Guo,J., Li,N., Liu,Q., Hao,Z., Zhu,G., Wang,X., Wang,H., Pan,Q.,
            Xu,B., Han,Y., Zhang,G., Lian,Y., Zhang,W., Gu,Y., Lin,N., Zeng,X.,
            Jin,Z., Lan,W., Jiang,J., Gao,D., Dong,L., Yuan,H., Liang,C. and
            Qin,J.
  TITLE     KMT2C deficiency drives transdifferentiation of double-negative
            prostate cancer and confer resistance to AR-targeted therapy
  JOURNAL   Cancer Cell 43 (7), 1261-1278 (2025)
   PUBMED   40280125
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Chen,X., Sun,W., Kong,X., Ming,X., Zhang,Y., Yan,W., Mohibi,S.,
            Chen,M., Mitchell,K. and Zhang,J.
  TITLE     TAp63gamma is the primary isoform of TP63 for tumor suppression but
            not development
  JOURNAL   Cell Death Discov 11 (1), 51 (2025)
   PUBMED   39915463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Mills,A.A., Zheng,B., Wang,X.J., Vogel,H., Roop,D.R. and Bradley,A.
  TITLE     p63 is a p53 homologue required for limb and epidermal
            morphogenesis
  JOURNAL   Nature 398 (6729), 708-713 (1999)
   PUBMED   10227293
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Kaelin,W.G. Jr.
  TITLE     The emerging p53 gene family
  JOURNAL   J Natl Cancer Inst 91 (7), 594-598 (1999)
   PUBMED   10203277
  REMARK    Review article
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Augustin,M., Bamberger,C., Paul,D. and Schmale,H.
  TITLE     Cloning and chromosomal mapping of the human p53-related KET gene
            to chromosome 3q27 and its murine homolog Ket to mouse chromosome
            16
  JOURNAL   Mamm Genome 9 (11), 899-902 (1998)
   PUBMED   9799841
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Senoo,M., Seki,N., Ohira,M., Sugano,S., Watanabe,M., Inuzuka,S.,
            Okamoto,T., Tachibana,M., Tanaka,T., Shinkai,Y. and Kato,H.
  TITLE     A second p53-related protein, p73L, with high homology to p73
  JOURNAL   Biochem Biophys Res Commun 248 (3), 603-607 (1998)
   PUBMED   9703973
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Schmale,H. and Bamberger,C.
  TITLE     A novel protein with strong homology to the tumor suppressor p53
  JOURNAL   Oncogene 15 (11), 1363-1367 (1997)
   PUBMED   9315105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK048623.1, AF075439.1 and
            BC090649.1.
            
            Summary: This gene encodes tumor protein p63, a member of the p53
            family of transcription factors involved in cellular responses to
            stress and development. The family members include tumor proteins
            p53, p63, and p73, which have high sequence similarity to one
            another. This similarity allows p63 and p73 to transactivate
            p53-responsive genes causing cell cycle arrest and apoptosis. The
            family members can interact with each other in many ways, including
            direct and indirect protein interactions. This results in mutual
            regulation of target gene promoters. Tumor protein p63 -/- mice
            have several developmental defects which include the lack of limbs
            and other tissues, such as teeth and mammary glands, which develop
            as a result of interactions between mesenchyme and epithelium. Both
            alternative splicing and the use of alternative promoters result in
            multiple transcript variants encoding different protein
            isoforms.[provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (4) is an alternate promoter
            product; it lacks several 5' exons but has an alternate 5' exon, as
            compared to variant 1. The resulting isoform (d, also known as
            DNp63alpha) has a shorter and different N-terminus, as compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010152.1, AF075439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 17.37 cM"
     Protein         1..586
                     /product="tumor protein 63 isoform d"
                     /note="tumor protein 63"
                     /calculated_mol_wt=65658
     Region          83..264
                     /region_name="P53"
                     /note="P53 DNA-binding domain; cd08367"
                     /db_xref="CDD:176262"
     Site            order(150,153,214,218)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:176262"
     Site            order(151..153,155)
                     /site_type="other"
                     /note="dimerization site [polypeptide binding]"
                     /db_xref="CDD:176262"
     Site            order(215,217,224,249,251..253,256)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     Region          297..337
                     /region_name="P53_tetramer"
                     /note="P53 tetramerization motif; pfam07710"
                     /db_xref="CDD:462238"
     Region          449..513
                     /region_name="SAM_tumor-p63"
                     /note="SAM domain of tumor-p63 proteins; cd09572"
                     /db_xref="CDD:188971"
     CDS             1..586
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /coded_by="NM_011641.2:145..1905"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS28085.1"
                     /db_xref="GeneID:22061"
                     /db_xref="MGI:MGI:1330810"
ORIGIN      
        1 mlylennaqt qfsepqytnl gllnsmdqqi qngssstspy ntdhaqnsvt apspyaqpss
       61 tfdalspspa ipsntdypgp hsfdvsfqqs staksatwty stelkklycq iaktcpiqik
      121 vmtpppqgav irampvykka ehvtevvkrc pnhelsrefn egqiappshl irvegnshaq
      181 yvedpitgrq svlvpyeppq vgtefttvly nfmcnsscvg gmnrrpilii vtletrdgqv
      241 lgrrcfeari cacpgrdrka dedsirkqqv sdsakngdgt krpfrqnthg iqmtsikkrr
      301 spddellylp vrgretyeml lkikeslelm qylpqhtiet yrqqqqqqhq hllqkqtsmq
      361 sqssygnssp plnkmnsmnk lpsvsqlinp qqrnaltptt mpegmganip mmgthmpmag
      421 dmnglsptqa lppplsmpst shctppppyp tdcsivsfla rlgcsscldy fttqglttiy
      481 qiehysmddl aslkipeqfr haiwkgildh rqlhdfsspp hllrtpsgas tvsvgssetr
      541 gervidavrf tlrqtisfpp rdewndfnfd mdsrrnkqqr ikeege
//
LOCUS       NP_062380                530 aa            linear   ROD 27-AUG-2025
DEFINITION  T-box transcription factor TBX21 [Mus musculus].
ACCESSION   NP_062380 XP_982720
VERSION     NP_062380.2
DBSOURCE    REFSEQ: accession NM_019507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Risley,C.A., Schultz,M.D., Allie,S.R., Liu,S., Peel,J.N.,
            Nellore,A., Fucile,C.F., Scharer,C.D., Boss,J.M., Randall,T.D.,
            Rosenberg,A.F. and Lund,F.E.
  TITLE     Transcription factor T-bet regulates the maintenance and
            differentiation potential of lymph node and lung effector memory B
            cell subsets
  JOURNAL   Immunity 58 (7), 1706-1724 (2025)
   PUBMED   40543512
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Caloba,C., Sturtz,A.J., Lyons,T.A., John,L., Ramachandran,A.,
            Minns,A.M., Cannon,A.M., Whalley,J.P., Watts,T.H., Kaplan,M.H.,
            Lindner,S.E. and Vijay,R.
  TITLE     Systemic 4-1BB stimulation augments extrafollicular memory B cell
            formation and recall responses during Plasmodium infection
  JOURNAL   Cell Rep 44 (4), 115528 (2025)
   PUBMED   40215168
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Kak,G., Van Roy,Z., Fallet,R.W., Korshoj,L.E. and Kielian,T.
  TITLE     CD4+ T cell-innate immune crosstalk is critical during
            Staphylococcus aureus craniotomy infection
  JOURNAL   JCI Insight 10 (4), e183327 (2025)
   PUBMED   39989461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 530)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   5  (residues 1 to 530)
  AUTHORS   Peng,S.L., Szabo,S.J. and Glimcher,L.H.
  TITLE     T-bet regulates IgG class switching and pathogenic autoantibody
            production
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5545-5550 (2002)
   PUBMED   11960012
  REMARK    GeneRIF: T-bet regulates IgG class switching and pathogenic
            autoantibody production.
REFERENCE   6  (residues 1 to 530)
  AUTHORS   Szabo,S.J., Sullivan,B.M., Stemmann,C., Satoskar,A.R.,
            Sleckman,B.P. and Glimcher,L.H.
  TITLE     Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma
            production in CD4 and CD8 T cells
  JOURNAL   Science 295 (5553), 338-342 (2002)
   PUBMED   11786644
  REMARK    GeneRIF: required for control of IFN-gamma production in CD4 and NK
            cells, but not in CD8 cells
REFERENCE   7  (residues 1 to 530)
  AUTHORS   Finotto,S., Neurath,M.F., Glickman,J.N., Qin,S., Lehr,H.A.,
            Green,F.H., Ackerman,K., Haley,K., Galle,P.R., Szabo,S.J.,
            Drazen,J.M., De Sanctis,G.T. and Glimcher,L.H.
  TITLE     Development of spontaneous airway changes consistent with human
            asthma in mice lacking T-bet
  JOURNAL   Science 295 (5553), 336-338 (2002)
   PUBMED   11786643
  REMARK    GeneRIF: T-bet deficiency, in the absence of allergen exposure,
            induces a murine phenotype reminiscent of both acute and chronic
            human asthma.
REFERENCE   8  (residues 1 to 530)
  AUTHORS   Zhang,W.X. and Yang,S.Y.
  TITLE     Cloning and characterization of a new member of the T-box gene
            family
  JOURNAL   Genomics 70 (1), 41-48 (2000)
   PUBMED   11087660
REFERENCE   9  (residues 1 to 530)
  AUTHORS   Shier,P., Hofstra,C.L., Ma,X.J., Wu,Y., Ngo,K. and Fung-Leung,W.P.
  TITLE     Tbt-1, a new T-box transcription factor induced in activated Th1
            and CD8+ T cells
  JOURNAL   Immunogenetics 51 (10), 771-778 (2000)
   PUBMED   10970091
REFERENCE   10 (residues 1 to 530)
  AUTHORS   Szabo,S.J., Kim,S.T., Costa,G.L., Zhang,X., Fathman,C.G. and
            Glimcher,L.H.
  TITLE     A novel transcription factor, T-bet, directs Th1 lineage commitment
  JOURNAL   Cell 100 (6), 655-669 (2000)
   PUBMED   10761931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627445.21, BC137986.1 and AK054495.1.
            
            On Jul 2, 2009 this sequence version replaced NP_062380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054495.1, AK156271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.95 cM"
     Protein         1..530
                     /product="T-box transcription factor TBX21"
                     /note="T-cell-specific T-box transcription factor T-bet;
                     T-box protein 21; transcription factor TBLYM"
                     /calculated_mol_wt=57721
     Region          1..55
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            55
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Region          135..325
                     /region_name="T-box_TBX21"
                     /note="DNA-binding domain of T-box transcription factor 21
                     and related T-box proteins; cd20203"
                     /db_xref="CDD:410329"
     Site            order(163..164,197,199,242,245,261..262,302,304,310,313,
                     317..319,322..323)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410329"
     Site            order(181,183,193,213..214,216..218,224..225,252..255,
                     274..278,288)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410329"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by ABL1.
                     /evidence=ECO:0000269|PubMed:21690296; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            224
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            265
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by ABL1.
                     /evidence=ECO:0000269|PubMed:21690296; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23616576; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            304
                     /site_type="other"
                     /note="Essential for its interaction with RUNX1 and its
                     ability to inhibit RUNX1 transcriptional activity and
                     suppress TH17 lineage development.
                     /evidence=ECO:0000269|PubMed:21151104; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by ABL1.
                     /evidence=ECO:0000269|PubMed:21690296; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Region          <393..520
                     /region_name="T-box_assoc"
                     /note="T-box transcription factor-associated; pfam16176"
                     /db_xref="CDD:465042"
     Region          444..530
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28424242; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     Site            525
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by ITK.
                     /evidence=ECO:0000269|PubMed:15662016; propagated from
                     UniProtKB/Swiss-Prot (Q9JKD8.1)"
     CDS             1..530
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /coded_by="NM_019507.2:195..1787"
                     /db_xref="CCDS:CCDS25315.1"
                     /db_xref="GeneID:57765"
                     /db_xref="MGI:MGI:1888984"
ORIGIN      
        1 mgivepgcgd mltgtepmps degrgpgadq qhrffypepg aqdptdrrag sslgtpysgg
       61 alvpaapgrf lgsfayppra qvagfpgpge ffpppagaeg yppvdgypap dpraglypgp
      121 redyalpagl evsgklrval snhllwskfn qhqtemiitk qgrrmfpfls ftvaglepts
      181 hyrmfvdvvl vdqhhwryqs gkwvqcgkae gsmpgnrlyv hpdspntgah wmrqevsfgk
      241 lkltnnkgas nnvtqmivlq slhkyqprlh ivevndgepe aacsasnthv ftfqetqfia
      301 vtayqnaeit qlkidnnpfa kgfrenfesm yasvdtsvps ppgpncqllg gdpfspllsn
      361 qypvpsrfyp dlpgqpkdmi sqpywlgtpr ehsyeaefra vsmkptllps apgptvpyyr
      421 gqdvlapgag wpvapqyppk mspagwfrpm rtlpmdpglg sseeqgssps lwpevtslqp
      481 epsdsglgeg dtkrrrispy pssgdssspa gapspfdket egqfynyfpn
//
LOCUS       NP_075017                175 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin regulatory light chain 2, atrial isoform [Mus musculus].
ACCESSION   NP_075017
VERSION     NP_075017.2
DBSOURCE    REFSEQ: accession NM_022879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 175)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 175)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 175)
  AUTHORS   Teng,X., He,H., Yu,H., Zhang,X., Xing,J., Shen,J., Li,C., Wang,M.,
            Shao,L., Wang,Z., Yang,H., Zhang,Y. and Wu,Q.
  TITLE     LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic
            Heart Development
  JOURNAL   Int J Mol Sci 25 (15), 8184 (2024)
   PUBMED   39125754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 175)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (residues 1 to 175)
  AUTHORS   Schule,K.M., Weckerle,J., Probst,S., Wehmeyer,A.E., Zissel,L.,
            Schroder,C.M., Tekman,M., Kim,G.J., Schlagl,I.M., Sagar and
            Arnold,S.J.
  TITLE     Eomes restricts Brachyury functions at the onset of mouse
            gastrulation
  JOURNAL   Dev Cell 58 (18), 1627-1642 (2023)
   PUBMED   37633271
REFERENCE   6  (residues 1 to 175)
  AUTHORS   Dyson,E., Sucov,H.M., Kubalak,S.W., Schmid-Schonbein,G.W.,
            DeLano,F.A., Evans,R.M., Ross,J. Jr. and Chien,K.R.
  TITLE     Atrial-like phenotype is associated with embryonic ventricular
            failure in retinoid X receptor alpha -/- mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7386-7390 (1995)
   PUBMED   7638202
REFERENCE   7  (residues 1 to 175)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (residues 1 to 175)
  AUTHORS   Kubalak,S.W., Miller-Hance,W.C., O'Brien,T.X., Dyson,E. and
            Chien,K.R.
  TITLE     Chamber specification of atrial myosin light chain-2 expression
            precedes septation during murine cardiogenesis
  JOURNAL   J Biol Chem 269 (24), 16961-16970 (1994)
   PUBMED   8207020
REFERENCE   9  (residues 1 to 175)
  AUTHORS   Faerman,A. and Shani,M.
  TITLE     The expression of the regulatory myosin light chain 2 gene during
            mouse embryogenesis
  JOURNAL   Development 118 (3), 919-929 (1993)
   PUBMED   8076526
REFERENCE   10 (residues 1 to 175)
  AUTHORS   Lowey,S. and Risby,D.
  TITLE     Light chains from fast and slow muscle myosins
  JOURNAL   Nature 234 (5324), 81-85 (1971)
   PUBMED   4942892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA461005.1, AK146716.1 and AJ348866.1.
            
            On Sep 14, 2006 this sequence version replaced NP_075017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA461005.1, BC061100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.88 cM"
     Protein         1..175
                     /product="myosin regulatory light chain 2, atrial isoform"
                     /note="MLC-2a; myosin light chain 2a; myosin regulatory
                     light chain 7; myosin light chain, regulatory A"
                     /calculated_mol_wt=19319
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:F1SSF9; propagated from
                     UniProtKB/Swiss-Prot (Q9QVP4.1)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QVP4.1)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QVP4.1)"
     Region          28..168
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..175
                     /gene="Myl7"
                     /gene_synonym="MLC-2alpha; MLC2a; MYL2A; Mylc2a; RLC-A"
                     /coded_by="NM_022879.2:20..547"
                     /db_xref="CCDS:CCDS24408.1"
                     /db_xref="GeneID:17898"
                     /db_xref="MGI:MGI:107495"
ORIGIN      
        1 masrkagtrg kaaatkqaqr gssnvfsmfe qaqiqefkea fscidqnrdg iicksdlket
       61 ysqlgrvsvp eeeldamlqe gkgpinftvf ltlfgeklng tdpeeailsa frmfdpsgqg
      121 vvnkeefkql lmtqadkfsp aeveqlfalt pmdlagnidy kslcyiithg dekee
//
LOCUS       NP_001407286             365 aa            linear   ROD 27-AUG-2025
DEFINITION  LIM/homeobox protein Lhx2 isoform b [Mus musculus].
ACCESSION   NP_001407286 XP_006497802
VERSION     NP_001407286.1
DBSOURCE    REFSEQ: accession NM_001420357.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 365)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 365)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 365)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 365)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            On May 2, 2023 this sequence version replaced XP_006497802.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.8111004.1,
                                           SRR17253011.4609385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..365
                     /product="LIM/homeobox protein Lhx2 isoform b"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=39878
     Region          2..65
                     /region_name="LIM1_Lhx2"
                     /note="The first LIM domain of Lhx2; cd09469"
                     /db_xref="CDD:188853"
     Site            order(12,15,33,36,39,42,61,64)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188853"
     Region          70..128
                     /region_name="LIM2_Lhx2_Lhx9"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     cd09377"
                     /db_xref="CDD:188763"
     Site            order(74,77,96,99,102,105,124,127)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188763"
     Region          <206..337
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          226..282
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..365
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001420357.1:32..1129"
                     /note="isoform b is encoded by transcript variant 6"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mpsissdraa lcagcggkis dryyllavdk qwhmrclkcc ecklnlesel tcfskdgsiy
       61 ckedyyrrfs vqrcarchlg isasemvmra rdlvyhlncf tcttcnkmlt tgdhfgmkds
      121 lvycrlhfea llqgeypahf nhadvaaaaa aaaaaksagl gsaganplgl pyyngvgtvq
      181 kgrprkrksp gpgadlaayn aalscnenda ehldrdqpyp ssqktkrmrt sfkhhqlrtm
      241 ksyfainhnp dakdlkqlaq ktgltkrvlq vwfqnarakf rrnllrqent gvdktsdatl
      301 qtgtpsgpas elsnaslsps stpttltdlt sptlptvtsv ltsvpgnleg hephspsqtt
      361 ltnlf
//
LOCUS       NP_001277698             404 aa            linear   ROD 27-AUG-2025
DEFINITION  sequestosome-1 isoform 2 [Mus musculus].
ACCESSION   NP_001277698 XP_006532513
VERSION     NP_001277698.1
DBSOURCE    REFSEQ: accession NM_001290769.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Qi,W., Cai,Y. and Wang,X.
  TITLE     Hydroxychloroquine confers placental protection in antiphospholipid
            Syndrome: Mechanistic insights into autophagy regulation and
            trophoblast dysfunction
  JOURNAL   Biochem Biophys Res Commun 770, 151994 (2025)
   PUBMED   40393103
REFERENCE   3  (residues 1 to 404)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   4  (residues 1 to 404)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 404)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   6  (residues 1 to 404)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (residues 1 to 404)
  AUTHORS   Okazaki,M., Ito,S., Kawakita,K., Takeshita,S., Kawai,S.,
            Makishima,F., Oda,H. and Kakinuma,A.
  TITLE     Cloning, expression profile, and genomic organization of the mouse
            STAP/A170 gene
  JOURNAL   Genomics 60 (1), 87-95 (1999)
   PUBMED   10458914
REFERENCE   8  (residues 1 to 404)
  AUTHORS   Yanagawa,T., Yuki,K., Yoshida,H., Bannai,S. and Ishii,T.
  TITLE     Phosphorylation of A170 stress protein by casein kinase II-like
            activity in macrophages
  JOURNAL   Biochem Biophys Res Commun 241 (1), 157-163 (1997)
   PUBMED   9405250
REFERENCE   9  (residues 1 to 404)
  AUTHORS   Ishii,T., Yanagawa,T., Yuki,K., Kawane,T., Yoshida,H. and Bannai,S.
  TITLE     Low micromolar levels of hydrogen peroxide and proteasome
            inhibitors induce the 60-kDa A170 stress protein in murine
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 232 (1), 33-37 (1997)
   PUBMED   9125146
REFERENCE   10 (residues 1 to 404)
  AUTHORS   Ishii,T., Yanagawa,T., Kawane,T., Yuki,K., Seita,J., Yoshida,H. and
            Bannai,S.
  TITLE     Murine peritoneal macrophages induce a novel 60-kDa protein with
            structural similarity to a tyrosine kinase p56lck-associated
            protein in response to oxidative stress
  JOURNAL   Biochem Biophys Res Commun 226 (2), 456-460 (1996)
   PUBMED   8806656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY267273.1 and AK028898.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006532513.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region but maintains reading frame, compared to
            variant 1. The encoded isoform (2) is shorter, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8865137.4679.1, SRR8865136.2933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.36 cM"
     Protein         1..404
                     /product="sequestosome-1 isoform 2"
                     /note="ubiquitin-binding protein p62; oxidative stress
                     induced"
                     /calculated_mol_wt=44061
     Region          5..102
                     /region_name="PB1_p62"
                     /note="The PB1 domain is an essential part of p62 scaffold
                     protein (alias sequestosome 1,SQSTM) involved in cell
                     signaling, receptor internalization, and protein turnover.
                     The PB1 domain is a modular domain mediating specific
                     protein-protein interaction which...; cd06402"
                     /db_xref="CDD:99723"
     Region          126..166
                     /region_name="ZZ_NBR1_like"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     Drosophila ref(2)P, NBR1, Human sequestosome 1 and related
                     proteins. The ZZ motif coordinates two zinc ions and most
                     likely participates in ligand binding or molecular
                     scaffolding. Drosophila ref(2)P appears...; cd02340"
                     /db_xref="CDD:239080"
     Site            order(128,131,142,145,151,154,160,163)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239080"
     Site            order(128,131,151,154)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239080"
     Site            order(129,139,141,147,149)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239080"
     Site            order(142,145,160,163)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239080"
     Region          353..404
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Site            order(368..370,373..376,379..380,383,394..396)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270505"
     CDS             1..404
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /coded_by="NM_001290769.1:64..1278"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS70176.1"
                     /db_xref="GeneID:18412"
                     /db_xref="MGI:MGI:107931"
ORIGIN      
        1 masftvkayl lgkeeatrei rrfsfcfspe peaeaqaaag pgpcerllsr vavlfptlrp
       61 ggfqahyrde dgdlvafssd eeltmamsyv kddifriyik ekkecrrehr ppcaqeaprn
      121 mvhpnvicdg cngpvvgtry kcsvcpdydl csvcegkglh rehsklifpn pfghlsdsfs
      181 hsrwlrklkh ghfgwpgwem gppgnwsprp pragdgrpcp taesasappe dpnvnflknv
      241 gesvaaalsp lgievdidve hggkrsrltp ttpessstgt edksntqpss cssevskpdg
      301 agegpaqslt eqmkkiales vgqpeeqmes gncsggdddw thlsskevdp steadprlie
      361 slsqmlsmgf sdeggwltrl lqtknydiga aldtiqyskh pppl
//
LOCUS       NP_035811                 96 aa            linear   ROD 27-AUG-2025
DEFINITION  uteroglobin precursor [Mus musculus].
ACCESSION   NP_035811
VERSION     NP_035811.1
DBSOURCE    REFSEQ: accession NM_011681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 96)
  AUTHORS   Gomez-Lopez,S., Alhendi,A.S.N., Przybilla,M.J., Bordeu,I.,
            Whiteman,Z.E., Butler,T., Rouhani,M.J., Kalinke,L., Uddin,I.,
            Otter,K.E.J., Chandrasekharan,D.P., Lebrusant-Fernandez,M.,
            Shurr,A.Y.L., Durrenberger,P.F., Moore,D.A., Falzon,M.,
            Reading,J.L., Martincorena,I., Simons,B.D., Campbell,P.J. and
            Janes,S.M.
  TITLE     Aberrant basal cell clonal dynamics shape early lung carcinogenesis
  JOURNAL   Science 388 (6752), eads9145 (2025)
   PUBMED   40310937
REFERENCE   2  (residues 1 to 96)
  AUTHORS   Kashimada,A., Mizuno,T., Tanaka,E., Hosokawa,S., Udagawa,T.,
            Hiraoka,Y., Uchida,K., Morio,T., Kosaki,K. and Takagi,M.
  TITLE     De novo variant in RING finger protein 213 causes systemic
            vasculopathy
  JOURNAL   JCI Insight 10 (11), e190094 (2025)
   PUBMED   40485582
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 96)
  AUTHORS   Armstrong,D., Chang,C.Y., Hong,M.J., Green,L., Shen,Y., Hudson,W.,
            Mauk,K.E., Song,L.Z., Jammi,S., Casal,B., Burns,B., Creighton,C.J.,
            Carisey,A., Zhang,X.H., McKenna,N.J., Kang,S.W., Lee,H.S.,
            Decker,W., Corry,D.B. and Kheradmand,F.
  TITLE     MAGE-A4 induces non-small cell lung cancer and tumor-promoting
            plasma cell accumulation
  JOURNAL   Sci Adv 11 (7), eads4227 (2025)
   PUBMED   39937892
REFERENCE   4  (residues 1 to 96)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 96)
  AUTHORS   Kim,K.H., Kim,S.J., Eccles,J.D., Ascoli,C. and Park,G.Y.
  TITLE     Tumor immunogenicity regulates host immune responses, and
            conventional dendritic cell type 2 uptakes the majority of tumor
            antigens in an orthotopic lung cancer model
  JOURNAL   Cancer Immunol Immunother 73 (12), 237 (2024)
   PUBMED   39358651
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 96)
  AUTHORS   Ray,M.K., Magdaleno,S.W., Finegold,M.J. and DeMayo,F.J.
  TITLE     cis-acting elements involved in the regulation of mouse Clara
            cell-specific 10-kDa protein gene. In vitro and in vivo analysis
  JOURNAL   J Biol Chem 270 (6), 2689-2694 (1995)
   PUBMED   7852338
REFERENCE   7  (residues 1 to 96)
  AUTHORS   Stripp,B.R., Huffman,J.A. and Bohinski,R.J.
  TITLE     Structure and regulation of the murine Clara cell secretory protein
            gene
  JOURNAL   Genomics 20 (1), 27-35 (1994)
   PUBMED   8020953
REFERENCE   8  (residues 1 to 96)
  AUTHORS   Ray,M.K., Magdaleno,S., O'Malley,B.W. and DeMayo,F.J.
  TITLE     Cloning and characterization of the mouse Clara cell specific 10
            kDa protein gene: comparison of the 5'-flanking region with the
            human rat and rabbit gene
  JOURNAL   Biochem Biophys Res Commun 197 (1), 163-171 (1993)
   PUBMED   7916613
REFERENCE   9  (residues 1 to 96)
  AUTHORS   Margraf,L.R., Finegold,M.J., Stanley,L.A., Major,A., Hawkins,H.K.
            and DeMayo,F.J.
  TITLE     Cloning and tissue-specific expression of the cDNA for the mouse
            Clara cell 10 kD protein: comparison of endogenous expression to
            rabbit uteroglobin promoter-driven transgene expression
  JOURNAL   Am J Respir Cell Mol Biol 9 (3), 231-238 (1993)
   PUBMED   8398159
REFERENCE   10 (residues 1 to 96)
  AUTHORS   Sandmoller,A., Voss,A.K., Hahn,J., Redemann-Fibi,B., Suske,G. and
            Beato,M.
  TITLE     Cell-specific, developmentally and hormonally regulated expression
            of the rabbit uteroglobin transgene and the endogenous mouse
            uteroglobin gene in transgenic mice
  JOURNAL   Mech Dev 34 (1), 57-67 (1991)
   PUBMED   1911394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB595042.1 and AK145844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB596926.1, CB595042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..96
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.05 cM"
     Protein         1..96
                     /product="uteroglobin precursor"
                     /note="CCPBP; PCB-binding protein; uteroglobin;
                     Blastokinin; club cell secretory protein; club cells 10
                     kDa secretory protein; club cell 17 kDa protein; club cell
                     phospholipid-binding protein"
                     /calculated_mol_wt=8379
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2159
     mat_peptide     22..96
                     /product="Uteroglobin. /id=PRO_0000036366"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06318.1)"
                     /calculated_mol_wt=8379
     Region          22..90
                     /region_name="UTG"
                     /note="Uteroglobin; smart00096"
                     /db_xref="CDD:128407"
     Site            order(26..27,30,42,46,49,54..59,61..62,65,73,75..77,
                     79..80,83)
                     /site_type="other"
                     /note="Dimer interface [polypeptide binding]"
                     /db_xref="CDD:238346"
     Site            order(27,34,42,59,62,77,80..81)
                     /site_type="other"
                     /note="Hydrophobic pocket - steroid binding site [chemical
                     binding]"
                     /db_xref="CDD:238346"
     CDS             1..96
                     /gene="Scgb1a1"
                     /gene_synonym="CC10; CC16; CCSP; PCB-BP; UG; UGB; Utg"
                     /coded_by="NM_011681.2:56..346"
                     /db_xref="CCDS:CCDS37911.1"
                     /db_xref="GeneID:22287"
                     /db_xref="MGI:MGI:98919"
ORIGIN      
        1 mkiaititvv mlsiccssas sdicpgflqv leallmeses gyvaslkpfn pgsdlqnagt
       61 qlkrlvdtlp qetrinimkl tekiltsplc kqdlrf
//
LOCUS       NP_808280                895 aa            linear   ROD 27-AUG-2025
DEFINITION  catenin alpha-3 isoform 1 [Mus musculus].
ACCESSION   NP_808280
VERSION     NP_808280.2
DBSOURCE    REFSEQ: accession NM_177612.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 895)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 895)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
REFERENCE   3  (residues 1 to 895)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   4  (residues 1 to 895)
  AUTHORS   Weng,A., Rabin,E.E., Flozak,A.S., Chiarella,S.E., Aillon,R.P. and
            Gottardi,C.J.
  TITLE     Alpha-T-catenin is expressed in peripheral nerves as a constituent
            of Schwann cell adherens junctions
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36420826
  REMARK    GeneRIF: Alpha-T-catenin is expressed in peripheral nerves as a
            constituent of Schwann cell adherens junctions.
REFERENCE   5  (residues 1 to 895)
  AUTHORS   Zhang,Y.
  TITLE     SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells
  JOURNAL   Cell Tissue Res 389 (1), 145-157 (2022)
   PUBMED   35536443
  REMARK    GeneRIF: SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells.
REFERENCE   6  (residues 1 to 895)
  AUTHORS   Goossens,S., Janssens,B., Bonne,S., De Rycke,R., Braet,F., van
            Hengel,J. and van Roy,F.
  TITLE     A unique and specific interaction between alphaT-catenin and
            plakophilin-2 in the area composita, the mixed-type junctional
            structure of cardiac intercalated discs
  JOURNAL   J Cell Sci 120 (Pt 12), 2126-2136 (2007)
   PUBMED   17535849
  REMARK    GeneRIF: By providing an extra link between the cadherin-catenin
            complex and intermediate filaments, the binding of alphaT-catenin
            to plakophilin-2 is proposed to be a means of modulating and
            strengthening cell-cell adhesion between cardiac muscle cells.
REFERENCE   7  (residues 1 to 895)
  AUTHORS   Goossens,S., Janssens,B., Vanpoucke,G., De Rycke,R., van Hengel,J.
            and van Roy,F.
  TITLE     Truncated isoform of mouse alphaT-catenin is testis-restricted in
            expression and function
  JOURNAL   FASEB J 21 (3), 647-655 (2007)
   PUBMED   17185752
REFERENCE   8  (residues 1 to 895)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   9  (residues 1 to 895)
  AUTHORS   Janssens,B., Mohapatra,B., Vatta,M., Goossens,S., Vanpoucke,G.,
            Kools,P., Montoye,T., van Hengel,J., Bowles,N.E., van Roy,F. and
            Towbin,J.A.
  TITLE     Assessment of the CTNNA3 gene encoding human alpha T-catenin
            regarding its involvement in dilated cardiomyopathy
  JOURNAL   Hum Genet 112 (3), 227-236 (2003)
   PUBMED   12596047
REFERENCE   10 (residues 1 to 895)
  AUTHORS   Janssens,B., Goossens,S., Staes,K., Gilbert,B., van Hengel,J.,
            Colpaert,C., Bruyneel,E., Mareel,M. and van Roy,F.
  TITLE     alphaT-catenin: a novel tissue-specific beta-catenin-binding
            protein mediating strong cell-cell adhesion
  JOURNAL   J Cell Sci 114 (Pt 17), 3177-3188 (2001)
   PUBMED   11590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030166.1, AC153513.6 and AK142745.1.
            
            On Sep 1, 2009 this sequence version replaced NP_808280.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ380429.1, AK030166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..895
                     /product="catenin alpha-3 isoform 1"
                     /note="alpha-catenin-like protein; alpha T-catenin;
                     catenin (cadherin associated protein), alpha 3;
                     cadherin-associated protein; alphaT-catenin"
                     /calculated_mol_wt=99672
     Region          18..856
                     /region_name="Vinculin"
                     /note="Vinculin family; pfam01044"
                     /db_xref="CDD:460040"
     Site            160
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            361
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Region          635..660
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            647
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     CDS             1..895
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /coded_by="NM_177612.3:88..2775"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS23901.1"
                     /db_xref="GeneID:216033"
                     /db_xref="MGI:MGI:2661445"
ORIGIN      
        1 msaetpitln mdtqdlqiqt ftvekllepl iiqvttlvnc pqnpsnrkkg rskrarvlla
       61 sveeatwnll dkgemiakea tvlkeelaaa lqevrkeska lkvsaerftd dpcylpkrea
      121 vvqaaralla avtrllvlad midvmcllqh vssfqrtfes lknvsnksdl qrtyqklgke
      181 lesldylafk rqqdlkspsq rdeiagarat lkenspllhs icsaclehsd vaslkaskdt
      241 vceeiqnald visnasqgiq napappepqa atlgsafdel enlivlnplt vteedvrpsl
      301 ekrleaiisg aalladssct rdlhreriia ecnairqalq dllteymsnt gktersntln
      361 taivnmskkt rdlrrqlrka iidhisdsfl dttvpllvli eaakngrvke ikdyaaifhe
      421 htgrlvevan lacsmstned gikivriaan hletlcpqii naalalasrp ksqvvkntme
      481 mykrtwehyi hvlteavddi tsiddflavs eshiledvnk ciialrdqda dnldraagai
      541 rgraarvahi vagemdsyep gaytegvmrn vnfltstvip efvtqvnval dalsknslta
      601 lddnqfvdis kkiydtihdi rcsvmmirtp eeledvsdle ddhevrshts iqtegktdra
      661 kmtqlpeaek ekiaeqvadf kkvkskldae ieiwddtsnd iivlakkmcm immemtdftr
      721 gkgplkhttd viyaakmise sgsrmdvlar qianqcpdpp ckqdllayle qikfyshqlk
      781 icsqvkaeiq nlggelivsa ldsvtsliqa aknlmnavvq tvkmsyiast kiiriqssag
      841 prhpvvmwrm kapakkplik rekpeetwaa vrrgsakkki hpvqvmsefr grqvy
//
LOCUS       NP_032388                576 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-1 receptor type 1 isoform 1 precursor [Mus musculus].
ACCESSION   NP_032388 XP_984959
VERSION     NP_032388.1
DBSOURCE    REFSEQ: accession NM_008362.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 576)
  AUTHORS   Xing,C., Duan,T., Li,L., Chen,L., Zhang,P., Du,Y., Liu,S.,
            Annaparthi,N., Wang,S., Qian,C., Wang,H.Y. and Wang,R.F.
  TITLE     TH17 cells regulate chemokine expression in epithelial cells
            through C/EBPbeta and dictate host sensitivity to colitis and
            cancer immunity
  JOURNAL   Sci Adv 11 (31), eads3530 (2025)
   PUBMED   40749055
REFERENCE   2  (residues 1 to 576)
  AUTHORS   Chen,S., Savas,A., Atici,A., Lee,Y., Lane,M., Aubuchon,E.,
            Moreira,D., Hsu-Wilbraham,A., Shimada,K., Crother,T.R., Noval
            Rivas,M. and Arditi,M.
  TITLE     Interleukin-1 Signaling on Vascular Smooth Muscle Cells Accelerates
            Atherosclerosis in a Murine Model of Kawasaki Disease
  JOURNAL   J Am Heart Assoc 14 (11), e040687 (2025)
   PUBMED   40417796
REFERENCE   3  (residues 1 to 576)
  AUTHORS   Chen,Y.T., Lohia,G.K., Chen,S., Liu,Z., Wong Fok Lung,T., Wang,C.
            and Riquelme,S.A.
  TITLE     A host-pathogen metabolic synchrony that facilitates disease
            tolerance
  JOURNAL   Nat Commun 16 (1), 3729 (2025)
   PUBMED   40253414
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 576)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   5  (residues 1 to 576)
  AUTHORS   Horn,S., Schmid,M., Berest,I., Piattini,F., Zhang,J., de Bock,K.,
            Devuyst,O., Nlandu Khodo,S., Kisielow,J. and Kopf,M.
  TITLE     IL-1 protects from fatal systemic candidiasis in mice by inhibiting
            oxidative phosphorylation and hypoxia
  JOURNAL   Nat Commun 16 (1), 2626 (2025)
   PUBMED   40097388
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 576)
  AUTHORS   Deyerle,K.L., Sims,J.E., Dower,S.K. and Bothwell,M.A.
  TITLE     Pattern of IL-1 receptor gene expression suggests role in
            noninflammatory processes
  JOURNAL   J Immunol 149 (5), 1657-1665 (1992)
   PUBMED   1387148
REFERENCE   7  (residues 1 to 576)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (residues 1 to 576)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     Distribution of type I interleukin-1 receptor messenger RNA in
            testis: an in situ histochemical study in the mouse
  JOURNAL   Neuroendocrinology 56 (1), 94-99 (1992)
   PUBMED   1386414
REFERENCE   9  (residues 1 to 576)
  AUTHORS   Ye,K., Koch,K.C., Clark,B.D. and Dinarello,C.A.
  TITLE     Interleukin-1 down-regulates gene and surface expression of
            interleukin-1 receptor type I by destabilizing its mRNA whereas
            interleukin-2 increases its expression
  JOURNAL   Immunology 75 (3), 427-434 (1992)
   PUBMED   1533388
REFERENCE   10 (residues 1 to 576)
  AUTHORS   Cunningham,E.T. Jr., Wada,E., Carter,D.B., Tracey,D.E., Battey,J.F.
            and De Souza,E.B.
  TITLE     In situ histochemical localization of type I interleukin-1 receptor
            messenger RNA in the central nervous system, pituitary, and adrenal
            gland of the mouse
  JOURNAL   J Neurosci 12 (3), 1101-1114 (1992)
   PUBMED   1532025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135085.3 and AC167168.5.
            
            On May 4, 2006 this sequence version replaced XP_984959.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20658.1, SRR17253014.3183290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 18.81 cM"
     Protein         1..576
                     /product="interleukin-1 receptor type 1 isoform 1
                     precursor"
                     /EC_number="3.2.2.6"
                     /note="interleukin-1 receptor type 1; interleukin-1
                     receptor alpha; CD121 antigen-like family member A; IL-1
                     receptor alpha chain"
                     /calculated_mol_wt=64598
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2118
     Region          27..117
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          42..46
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409583"
     Region          57..61
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409583"
     Site            63
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          82..86
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409583"
     Region          96..101
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409583"
     Site            103
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          109..112
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409583"
     Region          131..220
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          141..145
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409586"
     Region          160..164
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409586"
     Site            174
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          182..186
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409586"
     Region          196..201
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409586"
     Region          213..216
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409586"
     Region          229..332
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            236
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          247..251
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Site            252
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          260..264
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          297..301
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Region          312..317
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          325..328
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            339..359
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P13504.1)"
     Region          387..542
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     Site            499
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P14778; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     Site            556
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC.
                     /evidence=ECO:0000269|PubMed:1828344; propagated from
                     UniProtKB/Swiss-Prot (P13504.1)"
     CDS             1..576
                     /gene="Il1r1"
                     /gene_synonym="CD121a; CD121b; IL-1R-1; IL-1R-alpha;
                     IL-1R1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1"
                     /coded_by="NM_008362.3:247..1977"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS35547.1"
                     /db_xref="GeneID:16177"
                     /db_xref="MGI:MGI:96545"
ORIGIN      
        1 menmkvllgl iclmvpllsl eidvcteypn qivlflsvne idirkcpltp nkmhgdtiiw
       61 ykndsktpis adrdsrihqq nehlwfvpak vedsgyyyci vrnstyclkt kvtvtvlend
      121 pglcystqat fpqrlhiagd gslvcpyvsy fkdennelpe vqwyknckpl lldnvsffgv
      181 kdkllvrnva eehrgdyicr msytfrgkqy pvtrviqfit idenkrdrpv ilsprnetie
      241 adpgsmiqli cnvtgqfsdl vywkwngsei ewndpflaed yqfvehpstk rkytlittln
      301 isevksqfyr ypficvvknt nifesahvql iypvpdfkny liggfiilta tivccvciyk
      361 vfkvdivlwy rdscsgflps kasdgktyda yilypktlge gsfsdldtfv fkllpevleg
      421 qfgyklfiyg rddyvgedti evtnenvkks rrliiilvrd mggfswlgqs seeqiaiyna
      481 liqegikivl lelekiqdye kmpdsiqfik qkhgvicwsg dfqerpqsak trfwknlryq
      541 mpaqrrspls khrlltldpv rdtkeklpaa thlplg
//
LOCUS       NP_034790                561 aa            linear   ROD 27-AUG-2025
DEFINITION  keratin, type I cytoskeletal 10 [Mus musculus].
ACCESSION   NP_034790 XP_283025
VERSION     NP_034790.2
DBSOURCE    REFSEQ: accession NM_010660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 561)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 561)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   3  (residues 1 to 561)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   4  (residues 1 to 561)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 561)
  AUTHORS   Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
            Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
  TITLE     VAMP2 controls murine epidermal differentiation and carcinogenesis
            by regulation of nucleophagy
  JOURNAL   Dev Cell 59 (15), 2005-2016 (2024)
   PUBMED   38810653
REFERENCE   6  (residues 1 to 561)
  AUTHORS   Fuchs,E., Esteves,R.A. and Coulombe,P.A.
  TITLE     Transgenic mice expressing a mutant keratin 10 gene reveal the
            likely genetic basis for epidermolytic hyperkeratosis
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6906-6910 (1992)
   PUBMED   1379726
REFERENCE   7  (residues 1 to 561)
  AUTHORS   Kartasova,T., Roop,D.R. and Yuspa,S.H.
  TITLE     Relationship between the expression of differentiation-specific
            keratins 1 and 10 and cell proliferation in epidermal tumors
  JOURNAL   Mol Carcinog 6 (1), 18-25 (1992)
   PUBMED   1380247
REFERENCE   8  (residues 1 to 561)
  AUTHORS   Kaytes,P.S., McNab,A.R., Rea,T.J., Groppi,V., Kawabe,T.T.,
            Buhl,A.E., Bertolino,A.P., Hatzenbuhler,N.T. and Vogeli,G.
  TITLE     Hair-specific keratins: characterization and expression of a mouse
            type I keratin gene
  JOURNAL   J Invest Dermatol 97 (5), 835-842 (1991)
   PUBMED   1717610
REFERENCE   9  (residues 1 to 561)
  AUTHORS   Lussier,M., Filion,M., Compton,J.G., Nadeau,J.H., Lapointe,L. and
            Royal,A.
  TITLE     The mouse keratin 19-encoding gene: sequence, structure and
            chromosomal assignment
  JOURNAL   Gene 95 (2), 203-213 (1990)
   PUBMED   1701153
REFERENCE   10 (residues 1 to 561)
  AUTHORS   Ouellet,T., Lussier,M., Babai,F., Lapointe,L. and Royal,A.
  TITLE     Differential expression of the epidermal K1 and K10 keratin genes
            during mouse embryo development
  JOURNAL   Biochem Cell Biol 68 (2), 448-453 (1990)
   PUBMED   1693084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB648004.1, AK076508.1 and AI173281.1.
            
            On Aug 23, 2006 this sequence version replaced NP_034790.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081402.1, AK076508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     Protein         1..561
                     /product="keratin, type I cytoskeletal 10"
                     /note="epidermal keratin 10; intermediate filament
                     protein; CK-10; cytokeratin-10; 56 kDa cytokeratin;
                     keratin, type I cytoskeletal 59 kDa; keratin complex 1,
                     acidic, gene 10; suprabasal cytokeratin 10"
                     /calculated_mol_wt=56910
     Region          134..443
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     CDS             1..561
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /coded_by="NM_010660.2:33..1718"
                     /db_xref="CCDS:CCDS25380.1"
                     /db_xref="GeneID:16661"
                     /db_xref="MGI:MGI:96685"
ORIGIN      
        1 msvlyssssk qfsssrsggg ggggsvrvss trgslgggys sggfsggsfs rgssgggcfg
       61 gssggyggfg gggsfgggyg gssfgggygg ssfgggsfgg ggsfgggsfg ggsygggfgg
      121 ggfggdggsl lsgnekvtmq nlndrlasym dkvraleesn yelegkikew yekhgnssqr
      181 eprdyskyyk tiedlkgqil tlttdnanvl lqidnarlaa ddfrlkyene vtlrqsvead
      241 inglrrvlde ltlsksdlem qieslneela ylkknheeem rdlqnvstgd vnvemnaapg
      301 vdltqllnnm rnqyeqlaek nrkdaeewfn qkskelttei dsnieqmssh kseitelrrt
      361 vqgleielqs qlalkqslea slaetegryc vqlsqiqsqi saleeqlqqi raetecqnae
      421 yqqlldiktr leneiqtyrs llegegsssg ggggrgggsh ggsyggssgg gsyggssggg
      481 gsyggssggg gsygggssgg gshggssggg ygggsssgga gghggssggg ygggsssggq
      541 ggsggfkssg ggdqsskgpr y
//
LOCUS       NP_001164008             466 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 1 [Mus musculus].
ACCESSION   NP_001164008
VERSION     NP_001164008.1
DBSOURCE    REFSEQ: accession NM_001170537.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 466)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 466)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 466)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107750.9, CT025631.2 and CU074400.3.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the central coding region, compared to variant 3, resulting
            in an isoform (1) that is shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132573.1, SRR10223970.16219.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..466
                     /product="myocyte-specific enhancer factor 2C isoform 1"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=50262
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            4
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:18086704; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:8663403; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          91..118
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            116
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            119
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            234
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            239
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            252
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            264
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            285
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          360..391
                     /region_name="Transcription repressor.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          367..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            388
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            412
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK7.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            425..426
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     CDS             1..466
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001170537.2:445..1845"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49320.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv nqrinnsqsa qslatpvvsv atptlpgqgm
      301 ggypsaistt ygteyslssa dlsslsgfnt asalhlgsvt gwqqqhlhnm ppsalsqlga
      361 ctsthlsqss nlslpstqsl siksepvspp rdrtttpsry pqhttrheag rspvdslssc
      421 sssydgsdre dhrnefhspi gltrpspder espsvkrmrl segwat
//
LOCUS       NP_001390033            1582 aa            linear   ROD 27-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 8 isoform 3 [Mus
            musculus].
ACCESSION   NP_001390033 XP_006540812
VERSION     NP_001390033.1
DBSOURCE    REFSEQ: accession NM_001403104.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1582)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (residues 1 to 1582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1582)
  AUTHORS   Osipovich,A.B., Zhou,F.Y., Chong,J.J., Trinh,L.T., Cottam,M.A.,
            Shrestha,S., Cartailler,J.P. and Magnuson,M.A.
  TITLE     Deletion of Ascl1 in pancreatic beta-cells improves insulin
            secretion, promotes parasympathetic innervation, and attenuates
            dedifferentiation during metabolic stress
  JOURNAL   Mol Metab 78, 101811 (2023)
   PUBMED   37769990
REFERENCE   4  (residues 1 to 1582)
  AUTHORS   Peterson,S.M., Juliana,C.A., Hu,C.F., Chai,J., Holliday,C.,
            Chan,K.Y., Lujan Hernandez,A.G., Challocombe,Z., Wang,L., Han,Z.,
            Haas,N., Stafford,R., Axelrod,F., Yuan,T.Z., De Leon,D.D. and
            Sato,A.K.
  TITLE     Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist
            Antibody for Treatment of Hyperinsulinism
  JOURNAL   Diabetes 72 (9), 1320-1329 (2023)
   PUBMED   37358194
REFERENCE   5  (residues 1 to 1582)
  AUTHORS   Stokum,J.A., Shim,B., Negoita,S., Tsymbalyuk,N., Tsymbalyuk,O.,
            Ivanova,S., Keledjian,K., Bryan,J., Blaustein,M.P., Jha,R.M.,
            Kahle,K.T., Gerzanich,V. and Simard,J.M.
  TITLE     Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet
            induces water influx through AQP4 and brain swelling after ischemic
            stroke
  JOURNAL   Sci Signal 16 (788), eadd6364 (2023)
   PUBMED   37279286
REFERENCE   6  (residues 1 to 1582)
  AUTHORS   Hernandez-Sanchez,C., Wood,T.L. and LeRoith,D.
  TITLE     Developmental and tissue-specific sulfonylurea receptor gene
            expression
  JOURNAL   Endocrinology 138 (2), 705-711 (1997)
   PUBMED   9003005
REFERENCE   7  (residues 1 to 1582)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   8  (residues 1 to 1582)
  AUTHORS   Chung,W.K., Goldberg-Berman,J., Power-Kehoe,L. and Leibel,R.L.
  TITLE     Molecular mapping of the tubby (tub) mutation on mouse chromosome 7
  JOURNAL   Genomics 32 (2), 210-217 (1996)
   PUBMED   8833147
REFERENCE   9  (residues 1 to 1582)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   10 (residues 1 to 1582)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120135.7 and AC115036.10.
            
            On Mar 28, 2022 this sequence version replaced XP_006540812.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.17632.1,
                                           SRR9219382.128065.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1582
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     Protein         1..1582
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 3"
                     /note="sulfonylurea receptor; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 8"
                     /calculated_mol_wt=177147
     Region          224..1579
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1582
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /coded_by="NM_001403104.1:69..4817"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:20927"
                     /db_xref="MGI:MGI:1352629"
ORIGIN      
        1 mplafcgten hsaayrvdqg vlnngcfvda lnvvphvfll fitfpilfig wgsqsskvhi
       61 hhstwlhfpg hnlrwiltfm llfvlvceia egilsdgvte srhlhlympa gmafmaaits
      121 vvyyhniets nfpklliall iywtlafitk tikfvkfydh aigfsqlrfc ltgllvilyg
      181 mlllveinvi rvrryiffkt prevkppedl qdlgvrflqp fvnllskgty wwmnafikta
      241 hrkpidlrai gklpiamral tnyqrlcaaf daqarkdtqs qqgaraiwra lchafgrrlv
      301 lsstfrilad llgfagplci fgivdhlgke nhvfqpktqf lgvyfvssqe flgnayvlav
      361 llflalllqr tflqasyyva ietginlrga iqtkiynkim hlstsnlsmg emtagqicnl
      421 vaidtnqlmw ffflcpnlwa mpvqiivgvi llyyilgvsa ligaaviill apvqyfvatk
      481 lsqaqrstle ysnerlkqtn emlrgikllk lyawenifcs rvemtrrkem tslrafavyt
      541 sisifmntai piaavlitfv ghvsffkesd fspsvafasl slfhilvtpl fllssvvrst
      601 vkalvsvqkl seflssaeir eeqcaprepa pqgqagkyqa vplkvvnrkr pareevrdll
      661 gplqrltpsm dgdadnfcvq iiggfftwtp dgiptlsnit iriprgqltm ivgqvgcgks
      721 slllatlgem qrvsgavfwn sslpdseged psnperetaa dsdarsrgpv ayasqkpwll
      781 natveenitf espfnkqryk mvieacslqp didilphgdq tqigerginl sggqrqrisv
      841 aralyqhtnv vflddpfsal dvhlsdhlmq agilellrdd krtvvlvthk lqylphadwi
      901 iamkdgtiqr egtlkdfqrs ecqlfehwkt lmnrqdqele ketvmerkap epsqglpram
      961 ssrdglllde deeeeeaaes eeddnlssvl hqrakipwra ctkylssagv lllsllvfsq
     1021 llkhmvlvai dywlakwtds alvlspaarn cslsqecald qsvyamvftv lcslgialcl
     1081 vtsvtvewtg lkvakrlhrs llnriilapm rffettplgs ilnrfssdcn tidqhipstl
     1141 eclsrstllc vsaltvisyv tpvflvallp lavvcyfiqk yfrvasrdlq qlddttqlpl
     1201 lshfaetveg lttirafrye arfqqklley tdsnniaslf ltaanrwlev rmeyigacvv
     1261 liaaatsisn slhrelsagl vglgltyalm vsnylnwmvr nladmeiqlg avkrihtllk
     1321 teaesyegll apslipknwp dqgkiqiqnl svrydsslkp vlkhvnalia pgqkigicgr
     1381 tgsgkssfsl affrmvdmfe griiidgidi aklplhtlrs rlsiilqdpv lfsgtirfnl
     1441 dpekkcsdst lwealeiaql klvvkalpgg ldaiitegge nfsqgqrqlf clarafvrkt
     1501 sifimdeata sidmatenil qkvvmtafad rtvvtiahrv htilsadlvm vlkrgailef
     1561 dkpekllsqk dsvfasfvra dk
//
LOCUS       NP_031997                746 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 1 [Mus musculus].
ACCESSION   NP_031997
VERSION     NP_031997.2
DBSOURCE    REFSEQ: accession NM_007971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 746)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 746)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 746)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 746)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 746)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 746)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 746)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 746)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 746)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 746)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157853.1, AK220174.1 and BC079538.1.
            
            On Apr 9, 2009 this sequence version replaced NP_031997.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). This isoform is also
            known as ENX-1A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157853.1, BC003772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..746
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     1"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85161
     Region          1..340
                     /region_name="Interaction with DNMT1, DNMT3A and DNMT3B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          329..522
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          340..426
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            487
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          559..590
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          609..728
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(613,615..618,620,624,627,629,679..680,683,703,719)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(621..624,641,648,651..652,655,659,662..668,685..689,
                     697,724,726..727)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..689,726)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..688)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(641,648,651..652,655,659,664,666..668,697,724,
                     726..728)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..746
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_007971.2:145..2385"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20096.1"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhpfh
      301 atpntykrkn tetaldnkpc gpqcyqhleg akefaaalta eriktppkrp ggrrrgrlpn
      361 nssrpstpti svleskdtds dreagtetgg enndkeeeek kdetssssea nsrcqtpikm
      421 kpnieppenv ewsgaeasmf rvligtyydn fcaiarligt ktcrqvyefr vkessiiapv
      481 ptedvdtppr kkkrkhrlwa ahcrkiqlkk dgssnhvyny qpcdhprqpc dsscpcviaq
      541 nfcekfcqcs secqnrfpgc rckaqcntkq cpcylavrec dpdlcltcga adhwdsknvs
      601 ckncsiqrgs kkhlllapsd vagwgifikd pvqknefise ycgeiisqde adrrgkvydk
      661 ymcsflfnln ndfvvdatrk gnkirfanhs vnpncyakvm mvngdhrigi fakraiqtge
      721 elffdyrysq adalkyvgie remeip
//
LOCUS       NP_659093                724 aa            linear   ROD 27-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform 1
            precursor [Mus musculus].
ACCESSION   NP_659093
VERSION     NP_659093.2
DBSOURCE    REFSEQ: accession NM_144844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 724)
  AUTHORS   He,W., Marchuk,H., Koeberl,D., Kasumov,T., Chen,X. and Zhang,G.F.
  TITLE     Fasting alleviates metabolic alterations in mice with propionyl-CoA
            carboxylase deficiency due to Pcca mutation
  JOURNAL   Commun Biol 7 (1), 659 (2024)
   PUBMED   38811689
  REMARK    GeneRIF: Fasting alleviates metabolic alterations in mice with
            propionyl-CoA carboxylase deficiency due to Pcca mutation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 724)
  AUTHORS   Soria,L.R., Makris,G., D'Alessio,A.M., De Angelis,A., Boffa,I.,
            Pravata,V.M., Rufenacht,V., Attanasio,S., Nusco,E., Arena,P.,
            Ferenbach,A.T., Paris,D., Cuomo,P., Motta,A., Nitzahn,M.,
            Lipshutz,G.S., Martinez-Pizarro,A., Richard,E., Desviat,L.R.,
            Haberle,J., van Aalten,D.M.F. and Brunetti-Pierri,N.
  TITLE     O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and
            promotes ureagenesis
  JOURNAL   Nat Commun 13 (1), 5212 (2022)
   PUBMED   36064721
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 724)
  AUTHORS   Subramanian,C., Frank,M.W., Tangallapally,R., Yun,M.K., Edwards,A.,
            White,S.W., Lee,R.E., Rock,C.O. and Jackowski,S.
  TITLE     Pantothenate kinase activation relieves coenzyme A sequestration
            and improves mitochondrial function in mice with propionic acidemia
  JOURNAL   Sci Transl Med 13 (611), eabf5965 (2021)
   PUBMED   34524863
REFERENCE   5  (residues 1 to 724)
  AUTHORS   Jiang,L., Park,J.S., Yin,L., Laureano,R., Jacquinet,E., Yang,J.,
            Liang,S., Frassetto,A., Zhuo,J., Yan,X., Zhu,X., Fortucci,S.,
            Hoar,K., Mihai,C., Tunkey,C., Presnyak,V., Benenato,K.E.,
            Lukacs,C.M., Martini,P.G.V. and Guey,L.T.
  TITLE     Dual mRNA therapy restores metabolic function in long-term studies
            in mice with propionic acidemia
  JOURNAL   Nat Commun 11 (1), 5339 (2020)
   PUBMED   33087718
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 724)
  AUTHORS   Guenzel,A.J., Hofherr,S.E., Hillestad,M., Barry,M., Weaver,E.,
            Venezia,S., Kraus,J.P., Matern,D. and Barry,M.A.
  TITLE     Generation of a hypomorphic model of propionic acidemia amenable to
            gene therapy testing
  JOURNAL   Mol Ther 21 (7), 1316-1323 (2013)
   PUBMED   23648696
REFERENCE   7  (residues 1 to 724)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (residues 1 to 724)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 724)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 724)
  AUTHORS   Miyazaki,T., Ohura,T., Kobayashi,M., Shigematsu,Y., Yamaguchi,S.,
            Suzuki,Y., Hata,I., Aoki,Y., Yang,X., Minjares,C., Haruta,I.,
            Uto,H., Ito,Y. and Muller,U.
  TITLE     Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase
            and its rescue by postnatal, liver-specific supplementation via a
            transgene
  JOURNAL   J Biol Chem 276 (38), 35995-35999 (2001)
   PUBMED   11461925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144798.4, AC169511.1 and AC154499.2.
            
            On Jul 21, 2009 this sequence version replaced NP_659093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148002.1, BC049802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.99 cM"
     Protein         1..724
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform 1 precursor"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase alpha chain,
                     mitochondrial; propanoyl-CoA:carbon dioxide ligase subunit
                     alpha; propionyl CoA-carboxylase alpha; PCCase subunit
                     alpha"
                     /calculated_mol_wt=74430
     transit_peptide 1..48
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q91ZA3.2)"
                     /calculated_mol_wt=5510
     mat_peptide     49..724
                     /product="Propionyl-CoA carboxylase alpha chain,
                     mitochondrial. /id=PRO_0000002838"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZA3.2)"
                     /calculated_mol_wt=74430
     Region          59..508
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Site            61
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            146
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            150
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            196
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            324
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Site            492
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q91ZA3.2)"
     Region          521..649
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     Region          657..723
                     /region_name="biotinyl_domain"
                     /note="The biotinyl-domain or biotin carboxyl carrier
                     protein (BCCP) domain is present in all biotin-dependent
                     enzymes, such as acetyl-CoA carboxylase, pyruvate
                     carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA
                     carboxylase, geranyl-CoA carboxylase; cd06850"
                     /db_xref="CDD:133459"
     Site            order(680,689..691,698)
                     /site_type="active"
                     /note="carboxyltransferase (CT) interaction site [active]"
                     /db_xref="CDD:133459"
     Site            690
                     /site_type="other"
                     /note="biotinylation site [posttranslational
                     modification]"
                     /db_xref="CDD:133459"
     CDS             1..724
                     /gene="Pcca"
                     /coded_by="NM_144844.3:37..2211"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS27350.1"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
ORIGIN      
        1 magqwvrtva llaarrhwrr ssqqqllgtl khapvysyqc lvvsrslssv eyepkektfd
       61 kilianrgei acrviktckk mgiktvaihs dvdassvhvk madeavcvgp aptsksylnm
      121 daimeaikkt raqavhpgyg flsenkefak rlaaedvtfi gpdthaiqam gdkiesklla
      181 krakvntipg fdgvvkdade avriareigy pvmikasagg ggkgmriawd deetrdgfrf
      241 ssqeaassfg ddrlliekfi dnprhieiqv lgdkhgnalw lnerecsiqr rnqkvveeap
      301 sifldpetrq amgeqavala kavkyssagt veflvdsqkn fyflemntrl qvehpvteci
      361 tgldlvqemi lvakgyplrh kqedipisgw avecrvyaed pyksfglpsi grlsqyqepi
      421 hlpgvrvdsg iqpgsdisiy ydpmisklvt ygsdraealk rmedaldnyv irgvthnipl
      481 lreviintrf vkgdistkfl sdvypdgfkg htltlsernq llaiassvfv asqlraqrfq
      541 ehsrvpvirp dvakwelsvk lhdedhtvva snngpaftve vdgsklnvts twnlasplls
      601 vnvdgtqrtv qclsreaggn msiqflgtvy kvhiltklaa elnkfmlekv pkdtsstlcs
      661 pmpgvvvavs vkpgdmvaeg qeicvieamk mqnsmtagkm gkvklvhcka gdtvgegdll
      721 vele
//
LOCUS       NP_001364007             526 aa            linear   ROD 27-AUG-2025
DEFINITION  thymocyte selection-associated high mobility group box protein TOX
            [Mus musculus].
ACCESSION   NP_001364007 XP_006538008
VERSION     NP_001364007.1
DBSOURCE    REFSEQ: accession NM_001377078.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Huang,Y.J., Ngiow,S.F., Baxter,A.E., Manne,S., Park,S.L., Wu,J.E.,
            Khan,O., Giles,J.R. and Wherry,E.J.
  TITLE     Continuous expression of TOX safeguards exhausted CD8 T cell
            epigenetic fate
  JOURNAL   Sci Immunol 10 (105), eado3032 (2025)
   PUBMED   40053604
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Bao,K., Gu,X., Song,Y., Zhou,Y., Chen,Y., Yu,X., Yuan,W., Shi,L.,
            Zheng,J. and Hong,M.
  TITLE     TCF-1 and TOX regulate the memory formation of intestinal group 2
            innate lymphoid cells in asthma
  JOURNAL   Nat Commun 15 (1), 7850 (2024)
   PUBMED   39245681
  REMARK    GeneRIF: TCF-1 and TOX regulate the memory formation of intestinal
            group 2 innate lymphoid cells in asthma.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Das,A., Martinez-Ruiz,G.U., Bouladoux,N., Stacy,A., Moraly,J.,
            Vega-Sendino,M., Zhao,Y., Lavaert,M., Ding,Y., Morales-Sanchez,A.,
            Harly,C., Seedhom,M.O., Chari,R., Awasthi,P., Ikeuchi,T., Wang,Y.,
            Zhu,J., Moutsopoulos,N.M., Chen,W., Yewdell,J.W., Shapiro,V.S.,
            Ruiz,S., Taylor,N., Belkaid,Y. and Bhandoola,A.
  TITLE     Transcription factor Tox2 is required for metabolic adaptation and
            tissue residency of ILC3 in the gut
  JOURNAL   Immunity 57 (5), 1019-1036 (2024)
   PUBMED   38677292
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Laz,E.V., Holloway,M.G., Chen,C.S. and Waxman,D.J.
  TITLE     Characterization of three growth hormone-responsive transcription
            factors preferentially expressed in adult female liver
  JOURNAL   Endocrinology 148 (7), 3327-3337 (2007)
   PUBMED   17412818
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   9  (residues 1 to 526)
  AUTHORS   O'Flaherty,E. and Kaye,J.
  TITLE     TOX defines a conserved subfamily of HMG-box proteins
  JOURNAL   BMC Genomics 4 (1), 13 (2003)
   PUBMED   12697058
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671871.4 and AL831740.9.
            
            On Dec 12, 2019 this sequence version replaced XP_006538008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3636392.1,
                                           SRR17784645.1256658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 3.04 cM"
     Protein         1..526
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /note="thymus high mobility group box protein TOX;
                     thymocyte selection-associated HMG box"
                     /calculated_mol_wt=57072
     Region          194..264
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JW3.2)"
     Region          237..256
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JW3.2)"
     Region          262..331
                     /region_name="HMG-box_TOX-like"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; cd21995"
                     /db_xref="CDD:438811"
     Site            order(262..263,265..269,272..273,280,292..293,296,
                     299..300,307,311,314,318,321)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438811"
     CDS             1..526
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /coded_by="NM_001377078.1:211..1791"
                     /db_xref="GeneID:252838"
                     /db_xref="MGI:MGI:2181659"
ORIGIN      
        1 mdvrfypppa qpaaapaapc lgpspcldpy ycnkfdgenm ymsmtepsqd yvpasqsypg
       61 pslesedfni ppitppslpd hslvhlneve sgyhslchpm nhngllpfhp qtmdlpeitv
      121 snmlgqdgal lsnsisvmqe ignaegaqys shpqmaamrp rgqptdirqq asmmqpgqlt
      181 tinqsqlsaq lglnmggtnv ahnspsppgs ksatpspsss vhedecedas kinggekrpa
      241 sdmgkkpktp kkkkkkdpne pqkpvsayal ffrdtqaaik gqnpnatfge vskivasmwd
      301 glgeeqkqvy kkkteaakke ylkqlaayra slvsksytdp vdvktsqppq lvnskpsvfh
      361 gpsqahsaly lsshyhqqpg mtpqltamhp slprniapkp nnqmpvtvsi anmavspppp
      421 lqispplhqh lsmqqhqsla mqqplgsqlp mqvqtalhsp tmqqgftlqp dyqtiinpts
      481 taaqvvtqam eyvrsgcrnp ppqpvdwstd ycssggmqrd kalylt
//
LOCUS       NP_001095090             266 aa            linear   ROD 27-AUG-2025
DEFINITION  killer cell lectin-like receptor 8 isoform 1 [Mus musculus].
ACCESSION   NP_001095090 XP_001471827
VERSION     NP_001095090.1
DBSOURCE    REFSEQ: accession NM_001101620.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 266)
  AUTHORS   Vetters,J., van Helden,M., De Nolf,C., Rennen,S., Cloots,E., Van De
            Velde,E., Fayazpour,F., Van Moorleghem,J., Vanheerswynghels,M.,
            Vergote,K., Boon,L., Vivier,E., Lambrecht,B.N. and Janssens,S.
  TITLE     Canonical IRE1 function needed to sustain vigorous natural killer
            cell proliferation during viral infection
  JOURNAL   iScience 26 (12), 108570 (2023)
   PUBMED   38162021
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 266)
  AUTHORS   Khan,A.U.H., Ali,A.K., Marr,B., Jo,D., Ahmadvand,S.,
            Fong-McMaster,C., Almutairi,S.M., Wang,L., Sad,S., Harper,M.E. and
            Lee,S.H.
  TITLE     The TNFalpha/TNFR2 axis mediates natural killer cell proliferation
            by promoting aerobic glycolysis
  JOURNAL   Cell Mol Immunol 20 (10), 1140-1155 (2023)
   PUBMED   37553427
REFERENCE   3  (residues 1 to 266)
  AUTHORS   Potempa,M., Aguilar,O.A., Gonzalez-Hinojosa,M.D.R., Tenvooren,I.,
            Marquez,D.M., Spitzer,M.H. and Lanier,L.L.
  TITLE     Influence of Self-MHC Class I Recognition on the Dynamics of NK
            Cell Responses to Cytomegalovirus Infection
  JOURNAL   J Immunol 208 (7), 1742-1754 (2022)
   PUBMED   35321880
REFERENCE   4  (residues 1 to 266)
  AUTHORS   Riggan,L., Ma,F., Li,J.H., Fernandez,E., Nathanson,D.A.,
            Pellegrini,M. and O'Sullivan,T.E.
  TITLE     The transcription factor Fli1 restricts the formation of memory
            precursor NK cells during viral infection
  JOURNAL   Nat Immunol 23 (4), 556-567 (2022)
   PUBMED   35288713
REFERENCE   5  (residues 1 to 266)
  AUTHORS   Flommersfeld,S., Bottcher,J.P., Ersching,J., Flossdorf,M.,
            Meiser,P., Pachmayr,L.O., Leube,J., Hensel,I., Jarosch,S.,
            Zhang,Q., Chaudhry,M.Z., Andrae,I., Schiemann,M., Busch,D.H.,
            Cicin-Sain,L., Sun,J.C., Gasteiger,G., Victora,G.D., Hofer,T.,
            Buchholz,V.R. and Grassmann,S.
  TITLE     Fate mapping of single NK cells identifies a type 1 innate
            lymphoid-like lineage that bridges innate and adaptive recognition
            of viral infection
  JOURNAL   Immunity 54 (10), 2288-2304 (2021)
   PUBMED   34437840
REFERENCE   6  (residues 1 to 266)
  AUTHORS   Scalzo,A.A., Lyons,P.A., Fitzgerald,N.A., Forbes,C.A.,
            Yokoyama,W.M. and Shellam,G.R.
  TITLE     Genetic mapping of Cmv1 in the region of mouse chromosome 6
            encoding the NK gene complex-associated loci Ly49 and musNKR-P1
  JOURNAL   Genomics 27 (3), 435-441 (1995)
   PUBMED   7558024
REFERENCE   7  (residues 1 to 266)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 266)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   9  (residues 1 to 266)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
REFERENCE   10 (residues 1 to 266)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Simmons,A., La Vista,A.B. and
            Shellam,G.R.
  TITLE     Cmv-1, a genetic locus that controls murine cytomegalovirus
            replication in the spleen
  JOURNAL   J Exp Med 171 (5), 1469-1483 (1990)
   PUBMED   2159050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090127.11.
            
            On Sep 4, 2008 this sequence version replaced XP_001471827.1.
            
            Transcript Variant: represents the longer transcript and encodes
            the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12889.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     Protein         1..266
                     /product="killer cell lectin-like receptor 8 isoform 1"
                     /note="killer cell lectin-like receptor 8; ly-49h;
                     lymphocyte antigen 49h; T-cell surface glycoprotein
                     Ly-49H; cytomegalovirus resistance 1"
                     /calculated_mol_wt=31262
     Region          40..157
                     /region_name="Ly49"
                     /note="Ly49-like protein, N-terminal region; pfam08391"
                     /db_xref="CDD:462461"
     Site            45..66
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60682.1)"
     Site            87
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60682.1)"
     Site            104
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60682.1)"
     Region          145..259
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(198,225,243,245..246)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..266
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /coded_by="NM_001101620.1:146..946"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51927.1"
                     /db_xref="GeneID:16639"
                     /db_xref="MGI:MGI:102968"
ORIGIN      
        1 mseqevtfpt mrfhkssgln sqvrlegtqr srkaglrvcs vpwqlivial gilcslrlvi
       61 vavfvtkffq ysqhkqeine tlnhrhncsn mqrdfnlkee mltnksidcr psyelleyik
      121 reqerwdset ksvsdssrdt grgvkywfcy gtkcyyfimn kttwsgckan cqhysvpivk
      181 iededelkfl qrhvilesyw iglsydkkkk ewawihngqs kldmkikkmn ftsrgcvfls
      241 kariedtdcn tpyycicgkk ldkfpd
//
LOCUS       NP_001413966             676 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor protein 63 isoform i [Mus musculus].
ACCESSION   NP_001413966 XP_006522063
VERSION     NP_001413966.1
DBSOURCE    REFSEQ: accession NM_001427037.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 676)
  AUTHORS   Guo,J., Li,N., Liu,Q., Hao,Z., Zhu,G., Wang,X., Wang,H., Pan,Q.,
            Xu,B., Han,Y., Zhang,G., Lian,Y., Zhang,W., Gu,Y., Lin,N., Zeng,X.,
            Jin,Z., Lan,W., Jiang,J., Gao,D., Dong,L., Yuan,H., Liang,C. and
            Qin,J.
  TITLE     KMT2C deficiency drives transdifferentiation of double-negative
            prostate cancer and confer resistance to AR-targeted therapy
  JOURNAL   Cancer Cell 43 (7), 1261-1278 (2025)
   PUBMED   40280125
REFERENCE   2  (residues 1 to 676)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   3  (residues 1 to 676)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   4  (residues 1 to 676)
  AUTHORS   Chen,X., Sun,W., Kong,X., Ming,X., Zhang,Y., Yan,W., Mohibi,S.,
            Chen,M., Mitchell,K. and Zhang,J.
  TITLE     TAp63gamma is the primary isoform of TP63 for tumor suppression but
            not development
  JOURNAL   Cell Death Discov 11 (1), 51 (2025)
   PUBMED   39915463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 676)
  AUTHORS   Mills,A.A., Zheng,B., Wang,X.J., Vogel,H., Roop,D.R. and Bradley,A.
  TITLE     p63 is a p53 homologue required for limb and epidermal
            morphogenesis
  JOURNAL   Nature 398 (6729), 708-713 (1999)
   PUBMED   10227293
REFERENCE   6  (residues 1 to 676)
  AUTHORS   Kaelin,W.G. Jr.
  TITLE     The emerging p53 gene family
  JOURNAL   J Natl Cancer Inst 91 (7), 594-598 (1999)
   PUBMED   10203277
  REMARK    Review article
REFERENCE   7  (residues 1 to 676)
  AUTHORS   Augustin,M., Bamberger,C., Paul,D. and Schmale,H.
  TITLE     Cloning and chromosomal mapping of the human p53-related KET gene
            to chromosome 3q27 and its murine homolog Ket to mouse chromosome
            16
  JOURNAL   Mamm Genome 9 (11), 899-902 (1998)
   PUBMED   9799841
REFERENCE   8  (residues 1 to 676)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (residues 1 to 676)
  AUTHORS   Senoo,M., Seki,N., Ohira,M., Sugano,S., Watanabe,M., Inuzuka,S.,
            Okamoto,T., Tachibana,M., Tanaka,T., Shinkai,Y. and Kato,H.
  TITLE     A second p53-related protein, p73L, with high homology to p73
  JOURNAL   Biochem Biophys Res Commun 248 (3), 603-607 (1998)
   PUBMED   9703973
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
REFERENCE   10 (residues 1 to 676)
  AUTHORS   Schmale,H. and Bamberger,C.
  TITLE     A novel protein with strong homology to the tumor suppressor p53
  JOURNAL   Oncogene 15 (11), 1363-1367 (1997)
   PUBMED   9315105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113020.9 and AC109213.6.
            
            On Jan 9, 2024 this sequence version replaced XP_006522063.1.
            
            Summary: This gene encodes tumor protein p63, a member of the p53
            family of transcription factors involved in cellular responses to
            stress and development. The family members include tumor proteins
            p53, p63, and p73, which have high sequence similarity to one
            another. This similarity allows p63 and p73 to transactivate
            p53-responsive genes causing cell cycle arrest and apoptosis. The
            family members can interact with each other in many ways, including
            direct and indirect protein interactions. This results in mutual
            regulation of target gene promoters. Tumor protein p63 -/- mice
            have several developmental defects which include the lack of limbs
            and other tissues, such as teeth and mammary glands, which develop
            as a result of interactions between mesenchyme and epithelium. Both
            alternative splicing and the use of alternative promoters result in
            multiple transcript variants encoding different protein
            isoforms.[provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 17.37 cM"
     Protein         1..676
                     /product="tumor protein 63 isoform i"
                     /note="tumor protein 63"
                     /calculated_mol_wt=76189
     Region          1..107
                     /region_name="Transcription activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O88898.1)"
     Region          123..171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88898.1)"
     Region          177..358
                     /region_name="P53"
                     /note="P53 DNA-binding domain; cd08367"
                     /db_xref="CDD:176262"
     Site            order(244,247,308,312)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:176262"
     Site            order(245..247,249)
                     /site_type="other"
                     /note="dimerization site [polypeptide binding]"
                     /db_xref="CDD:176262"
     Site            order(309,311,318,343,345..347,350)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     Region          387..427
                     /region_name="P53_tetramer"
                     /note="P53 tetramerization motif; pfam07710"
                     /db_xref="CDD:462238"
     Region          390..439
                     /region_name="Oligomerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O88898.1)"
     Region          432..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88898.1)"
     Region          539..603
                     /region_name="SAM_tumor-p63"
                     /note="SAM domain of tumor-p63 proteins; cd09572"
                     /db_xref="CDD:188971"
     Region          606..676
                     /region_name="Transactivation inhibition.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O88898.1)"
     CDS             1..676
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /coded_by="NM_001427037.1:126..2156"
                     /note="isoform i is encoded by transcript variant 9"
                     /db_xref="GeneID:22061"
                     /db_xref="MGI:MGI:1330810"
ORIGIN      
        1 mnfetsrcat lqycpdpyiq rfietpahfs wkesyyrsam sqstqtsefl spevfqhiwd
       61 fleqpicsvq pielnfvdep sengatnkie ismdcirmqd sdlsdpmwpq ytnlgllnsm
      121 dqqiqngsss tspyntdhaq nsvtapspya qpsstfdals pspaipsntd ypgphsfdvs
      181 fqqsstaksa twtystelkk lycqiaktcp iqikvmtppp qgavirampv ykkaehvtev
      241 vkrcpnhels refnegqiap pshlirvegn shaqyvedpi tgrqsvlvpy eppqvgteft
      301 tvlynfmcns scvggmnrrp iliivtletr dgqvlgrrcf earicacpgr drkadedsir
      361 kqqvsdsakn gdafrqnthg iqmtsikkrr spddellylp vrgretyeml lkikeslelm
      421 qylpqhtiet yrqqqqqqhq hllqkqtsmq sqssygnssp plnkmnsmnk lpsvsqlinp
      481 qqrnaltptt mpegmganip mmgthmpmag dmnglsptqa lppplsmpst shctppppyp
      541 tdcsivsfla rlgcsscldy fttqglttiy qiehysmddl aslkipeqfr haiwkgildh
      601 rqlhdfsspp hllrtpsgas tvsvgssetr gervidavrf tlrqtisfpp rdewndfnfd
      661 mdsrrnkqqr ikeege
//
LOCUS       NP_001153061             698 aa            linear   ROD 27-AUG-2025
DEFINITION  NAD-dependent protein deacetylase sirtuin-1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001153061
VERSION     NP_001153061.1
DBSOURCE    REFSEQ: accession NM_001159589.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 698)
  AUTHORS   Hu,C., Geng,J., Shan,P., Zhang,T., Zhang,Z., Zhang,X., Lin,M.,
            Zhang,X., Chang,D., He,B., Jia,D., Zhang,M., Wang,C. and Zhang,S.
  TITLE     Deacetylation of nuclear AIF provides a braking mechanism for
            caspase-independent chromatinolysis and necrotic brain injury
  JOURNAL   Commun Biol 8 (1), 813 (2025)
   PUBMED   40425818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 698)
  AUTHORS   Zhao,Y., Wang,Y., Zheng,H., Xu,Q., Zhou,K., Liu,H., Xia,Y.,
            Wei,D.H., Jiang,M., Tang,Z.H., Liu,L.S., Zheng,H. and Jiang,Z.
  TITLE     Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced
            endothelial cell damage and mitochondrial dysfunction
  JOURNAL   Nitric Oxide 152, 78-89 (2024)
   PUBMED   39305980
  REMARK    GeneRIF: Hydrogen sulfide upregulates SIRT1 to inhibit
            ox-HDL-induced endothelial cell damage and mitochondrial
            dysfunction.
REFERENCE   3  (residues 1 to 698)
  AUTHORS   de Lima,J., Leite,J.A., Basso,P.J., Ghirotto,B., Martins da
            Silva,E., Menezes-Silva,L., Hiyane,M.I., Goes,C.P., Coutinho,L.L.,
            de Andrade Oliveira,V. and Olsen Saraiva Camara,N.
  TITLE     Sirtuin 1 regulates the phenotype and functions of dendritic cells
            through Ido1 pathway in obesity
  JOURNAL   Cell Death Dis 15 (10), 757 (2024)
   PUBMED   39424786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 698)
  AUTHORS   Nevoral,J., Drutovic,D., Vaskovicova,M., Benc,M., Liska,F.,
            Valentova,I., Stachovicova,S., Kubovciak,J., Havrankova,J.,
            Shavit,M., Monsef,L., Iniesta-Cuerda,M., Zalmanova,T., Hosek,P.,
            Strejcek,F., Kralickova,M. and Petr,J.
  TITLE     Dynamics and necessity of SIRT1 for maternal-zygotic transition
  JOURNAL   Sci Rep 14 (1), 21598 (2024)
   PUBMED   39285243
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 698)
  AUTHORS   Wu,L., Zhang,S., Zhang,M., Ou,Y. and Chen,J.
  TITLE     Occlusal disharmony promotes anxiety-like behaviours by suppressing
            Sirt1
  JOURNAL   Clin Oral Investig 28 (10), 526 (2024)
   PUBMED   39276172
  REMARK    GeneRIF: Occlusal disharmony promotes anxiety-like behaviours by
            suppressing Sirt1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 698)
  AUTHORS   Giblin,W., Skinner,M.E. and Lombard,D.B.
  TITLE     Sirtuins: guardians of mammalian healthspan
  JOURNAL   Trends Genet 30 (7), 271-286 (2014)
   PUBMED   24877878
  REMARK    Review article
REFERENCE   7  (residues 1 to 698)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
  REMARK    GeneRIF: Sirt1(Sir2alpha) deacetylates p53 and promotes survival
REFERENCE   8  (residues 1 to 698)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   9  (residues 1 to 698)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   10 (residues 1 to 698)
  AUTHORS   Imai,S., Armstrong,C.M., Kaeberlein,M. and Guarente,L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153516.8, AK140330.1,
            BE989110.1, BX523319.1, AK139946.1 and AK141245.1.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, characterized by their deacetylase activity and proposed
            role in longevity. The encoded protein regulates gene expression in
            a wide range of cell and tissue types through its NAD+-dependent
            deacetylation of histones, transcription factors and
            transcriptional coactivators. Brain-specific overexpression of this
            gene has been shown to result in increased median lifespan.
            Viability of homozygous knockout mice for this gene varies with
            strain background. Homozygous knockout mice of strains that do not
            exhibit embryonic lethality are sterile and have a reduced
            lifespan. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144203.1, SRR11927936.2947087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..698
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform 2"
                     /EC_number="2.3.1.286"
                     /note="SIR2-like protein 1; sirtuin 1 ((silent mating type
                     information regulation 2, homolog) 1; regulatory protein
                     SIR2 homolog 1; NAD-dependent protein deacetylase
                     sirtuin-1; NAD-dependent protein deacylase sirtuin-1"
                     /calculated_mol_wt=75913
     Region          207..442
                     /region_name="SIRT1"
                     /note="Eukaryotic group (class1) which includes human
                     sirtuins SIRT1-3 and yeast Hst1-4; and are members of the
                     SIR2 family of proteins, silent information regulator 2
                     (Sir2) enzymes which catalyze NAD+-dependent
                     protein/histone deacetylation. Sir2 proteins...; cd01408"
                     /db_xref="CDD:238699"
     Site            order(216,218..219,226..227,280,298..299,301,316,393,398,
                     419..420,434)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(300,316,365,367..371,397..399)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(324,327,348,351)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238699"
     CDS             1..698
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /coded_by="NM_001159589.2:66..2162"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48585.1"
                     /db_xref="GeneID:93759"
                     /db_xref="MGI:MGI:2135607"
ORIGIN      
        1 madevalalq aagspsaaaa meaasqpade plrkrprrdg pglgrspgep saavapaaag
       61 ceaasaaapa alwreaagaa asaereapat avagdgdngs glrrepraad dfdddegeee
      121 deaaaaaaaa aigyrgpytf vqqhlmigtd prtilkdllp etipppeldd mtlwqivini
      181 lseppkrkkr kdintiedav kllqeckkii vltgagvsvs cgipdfrsrd giyarlavdf
      241 pdlpdpqamf dieyfrkdpr pffkfakeiy pgqfqpslch kfialsdkeg kllrnytqni
      301 dtleqvagiq rilqchgsfa tasclickyk vdceavrgdi fnqvvprcpr cpadeplaim
      361 kpeivffgen lpeqfhramk ydkdevdlli vigsslkvrp valipssiph evpqilinre
      421 plphlhfdve llgdcdviin elchrlggey aklccnpvkl seitekpprp qkelvhlsel
      481 pptplhised ssspertvpq dssviatlvd qatnnnvndl evsesscvee kpqevqtsrn
      541 veninvenpd fkavgsstad knertsvaet vrkcwpnrla keqiskrleg nqylfvppnr
      601 yifhgaevys dseddvlsss scgsnsdsgt cqspsleepl edeseieefy ngleddterp
      661 ecaggsgfga dggdqevvne aiatrqeltd vnypsdks
//
LOCUS       NP_001415449             357 aa            linear   ROD 27-AUG-2025
DEFINITION  histone deacetylase 2 isoform c [Mus musculus].
ACCESSION   NP_001415449 XP_030100750
VERSION     NP_001415449.1
DBSOURCE    REFSEQ: accession NM_001428520.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 357)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 357)
  AUTHORS   Zrimsek,M., Draganic,K., Malzer,A., Doblmayr,V., Misura,K., de
            Freitas E Silva,R., Matthews,J.D., Iannelli,F., Wohlhaupter,S.,
            Perez Malla,C.U., Fischer,H., Schachner,H., Schiefer,A.I.,
            Sheibani-Tezerji,R., Chiarle,R., Turner,S.D., Ellmeier,W.,
            Seiser,C. and Egger,G.
  TITLE     HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large
            cell lymphoma: implications for HDAC inhibitor therapy
  JOURNAL   Leukemia 39 (6), 1412-1424 (2025)
   PUBMED   40175628
REFERENCE   3  (residues 1 to 357)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 357)
  AUTHORS   Iwamura,Y., Nakai,T., Kato,K., Ishioka,H., Yamamoto,M., Hirano,I.
            and Suzuki,N.
  TITLE     Erythropoietin Production in Embryonic Neural Cells is Controlled
            by Hypoxia Signaling and Histone Deacetylases with an
            Undifferentiated Cellular State
  JOURNAL   Mol Cell Biol 45 (1), 32-45 (2025)
   PUBMED   39620278
REFERENCE   5  (residues 1 to 357)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 357)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (residues 1 to 357)
  AUTHORS   Zeng,Y., Tang,C.M., Yao,Y.L., Yang,W.M. and Seto,E.
  TITLE     Cloning and characterization of the mouse histone deacetylase-2
            gene
  JOURNAL   J Biol Chem 273 (44), 28921-28930 (1998)
   PUBMED   9786895
REFERENCE   8  (residues 1 to 357)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   9  (residues 1 to 357)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (residues 1 to 357)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165370.4.
            
            On Mar 14, 2024 this sequence version replaced XP_030100750.1.
            
            Transcript Variant: This variant (3), as well as variant 4, encodes
            isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.523002.1,
                                           SRR7345562.4358065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 19.44 cM"
     Protein         1..357
                     /product="histone deacetylase 2 isoform c"
                     /EC_number="3.5.1.98"
                     /note="HD2; YY1 transcription factor-binding protein;
                     protein deacylase HDAC2"
                     /calculated_mol_wt=39942
     Region          <1..243
                     /region_name="Arginase_HDAC"
                     /note="Arginase-like and histone-like hydrolases; cl17011"
                     /db_xref="CDD:450134"
     Site            order(11,46,48,50,132,134,171)
                     /site_type="active"
                     /db_xref="CDD:212513"
     Site            order(46,48,134)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:212513"
     CDS             1..357
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /coded_by="NM_001428520.1:484..1557"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="GeneID:15182"
                     /db_xref="MGI:MGI:1097691"
ORIGIN      
        1 mavnwagglh hakkseasgf cyvndivlai lellkyhqrv lyididihhg dgveeafytt
       61 drvmtvsfhk ygeyfpgtgd lrdigagkgk yyavnfpmrd giddesygqi fkpiiskvme
      121 myqpsavvlq cgadslsgdr lgcfnltvkg hakcvevvkt fnlpllmlgg ggytirnvar
      181 cwtyetaval dceipnelpy ndyfeyfgpd fklhispsnm tnqntpeyme kikqrlfenl
      241 rmlphapgvq mqaipedavh edsgdedged pdkrisiras dkriacdeef sdsedegegg
      301 rrnvadhkkg akkarieedk ketedkktdv keedkskdns gektdpkgak seqlsnp
//
LOCUS       NP_033061                526 aa            linear   ROD 27-AUG-2025
DEFINITION  recombining binding protein suppressor of hairless isoform 1 [Mus
            musculus].
ACCESSION   NP_033061
VERSION     NP_033061.3
DBSOURCE    REFSEQ: accession NM_009035.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Chen,K.Y., Kibayashi,T., Giguelay,A., Hata,M., Nakajima,S.,
            Mikami,N., Takeshima,Y., Ichiyama,K., Omiya,R., Ludwig,L.S.,
            Hattori,K. and Sakaguchi,S.
  TITLE     Genome-wide CRISPR screen in human T cells reveals regulators of
            FOXP3
  JOURNAL   Nature 642 (8066), 191-200 (2025)
   PUBMED   40140585
  REMARK    Erratum:[Nature. 2025 Jul;643(8074):E25. doi:
            10.1038/s41586-025-09356-6. PMID: 40640568]
REFERENCE   3  (residues 1 to 526)
  AUTHORS   O'Hara,J., Dakle,P., Nguyen,M.L.T., Barugahare,A., Bennett,T.J.,
            Udupa,V.A., Murray,N., Schlegel,G., Kapouleas,C., Li,J.,
            Turner,S.J. and Russ,B.E.
  TITLE     Notch dependent chromatin remodeling enables Gata3 binding and
            drives lineage specific CD8+ T cell function
  JOURNAL   Immunol Cell Biol 103 (4), 365-382 (2025)
   PUBMED   40012375
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Nakisli,S., Fanelli,K., LaComb,J., Arnold,L.J. and Nielsen,C.M.
  TITLE     CNS resident macrophages exhibit region-specific states and
            immunogenic responses during Rbpj-deficient brain arteriovenous
            malformation
  JOURNAL   Sci Rep 15 (1), 3932 (2025)
   PUBMED   39890825
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and
            Israel,A.
  TITLE     Signalling downstream of activated mammalian Notch
  JOURNAL   Nature 377 (6547), 355-358 (1995)
   PUBMED   7566092
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Hamaguchi,Y., Mastunami,N., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     Cloning and characterization of a protein binding to the J kappa
            recombination signal sequence of immunoglobulin genes
  JOURNAL   Adv Exp Med Biol 292, 177-186 (1991)
   PUBMED   1950768
REFERENCE   9  (residues 1 to 526)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Siminovitch,K.A., Moore,M.W., Durdik,J. and Selsing,E.
  TITLE     The human kappa deleting element and the mouse recombining segment
            share DNA sequence homology
  JOURNAL   Nucleic Acids Res 15 (6), 2699-2705 (1987)
   PUBMED   3104881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152746.1, BY155397.1, AK132145.1 and AK028363.1.
            
            On Apr 28, 2006 this sequence version replaced NP_033061.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132145.1, AK152746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.37 cM"
     Protein         1..526
                     /product="recombining binding protein suppressor of
                     hairless isoform 1"
                     /note="recombining binding protein suppressor of hairless;
                     J-kappa recombination signal binding protein; Jkappa
                     recombination signal binding protein"
                     /calculated_mol_wt=58407
     Region          1..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P31266.1)"
     Region          74..204
                     /region_name="LAG1-DNAbind"
                     /note="LAG1, DNA binding; pfam09271"
                     /db_xref="CDD:462735"
     Region          83..93
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:18381292"
                     /note="propagated from UniProtKB/Swiss-Prot (P31266.1)"
     Region          191..196
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:18381292"
                     /note="propagated from UniProtKB/Swiss-Prot (P31266.1)"
     Site            201
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P31266.1)"
     Region          218..223
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:18381292"
                     /note="propagated from UniProtKB/Swiss-Prot (P31266.1)"
     Region          232..354
                     /region_name="BTD"
                     /note="Beta-trefoil DNA-binding domain; pfam09270"
                     /db_xref="CDD:462734"
     Region          376..472
                     /region_name="IPT_RBP-Jkappa"
                     /note="IPT domain of the recombination signal Jkappa
                     binding protein (RBP-Jkappa). RBP-J kappa, was initially
                     considered to be involved in V(D)J recombination because
                     of its DNA binding specificity and structural similarity
                     to site-specific recombinases known...; cd01176"
                     /db_xref="CDD:238581"
     Region          491..526
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P31266.1)"
     CDS             1..526
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /coded_by="NM_009035.5:5..1585"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19292.1"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
ORIGIN      
        1 mpsgfpqspr tsprarpktr itgalpmdys eglsaeerpa hapsagkfge rpppkrltre
       61 amrnylkerg dqtvlilhak vaqksygnek rffcpppcvy lmgsgwkkkk eqmerdgcse
      121 qesqpcafig ignsdqemqq lnlegknyct aktlyisdsd krkhfmlsvk mfygnsddig
      181 vflskrikvi skpskkkqsl knadlciasg tkvalfnrlr sqtvstrylh veggnfhass
      241 qqwgafyihl ldddesegee ftvrdgyihy gqtvklvcsv tgmalprlii rkvdkqtall
      301 daddpvsqlh kcafylkdte rmylclsqer iiqfqatpcp keqnkemind gaswtiistd
      361 kaeytfyegm gpvlapvtpv pvveslqlng ggdvamlelt gqnftpnlrv wfgdveaetm
      421 yrcgesmlcv vpdisafreg wrwvrqpvqv pvtlvrndgv iystsltfty tpepgprphc
      481 saagailran ssqvpsnesn tnsegnytna stnstsvtss tatvvs
//
LOCUS       NP_001272847             291 aa            linear   ROD 27-AUG-2025
DEFINITION  geminin coiled-coil domain-containing protein 1 isoform 3 [Mus
            musculus].
ACCESSION   NP_001272847
VERSION     NP_001272847.1
DBSOURCE    REFSEQ: accession NM_001285918.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 291)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 291)
  AUTHORS   Elorriaga,V., Bouloudi,B., Delberghe,E., Saillour,Y., Morel,J.S.,
            Azzam,P., Moreau,M.X., Stottmann,R., Bahi-Buisson,N., Pierani,A.,
            Spassky,N. and Causeret,F.
  TITLE     Differential contribution of P73+ Cajal-Retzius cells and Reelin to
            cortical morphogenesis
  JOURNAL   Development 152 (9) (2025)
   PUBMED   40207459
REFERENCE   3  (residues 1 to 291)
  AUTHORS   Kaplani,K., Lalioti,M.E., Vassalou,S., Lokka,G., Parlapani,E.,
            Kritikos,G., Lygerou,Z. and Taraviras,S.
  TITLE     Ependymal cell lineage reprogramming as a potential therapeutic
            intervention for hydrocephalus
  JOURNAL   EMBO Mol Med 16 (11), 2725-2748 (2024)
   PUBMED   39468302
REFERENCE   4  (residues 1 to 291)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 291)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   6  (residues 1 to 291)
  AUTHORS   Terre,B., Piergiovanni,G., Segura-Bayona,S., Gil-Gomez,G.,
            Youssef,S.A., Attolini,C.S., Wilsch-Brauninger,M., Jung,C.,
            Rojas,A.M., Marjanovic,M., Knobel,P.A., Palenzuela,L.,
            Lopez-Rovira,T., Forrow,S., Huttner,W.B., Valverde,M.A., de
            Bruin,A., Costanzo,V. and Stracker,T.H.
  TITLE     GEMC1 is a critical regulator of multiciliated cell differentiation
  JOURNAL   EMBO J 35 (9), 942-960 (2016)
   PUBMED   26933123
  REMARK    GeneRIF: The authors found that GEMC1-deficient mice are growth
            impaired, develop hydrocephaly with a high penetrance, and are
            infertile, due to defects in the formation of multiciliated cells
            in the brain, respiratory tract, and germline.
REFERENCE   7  (residues 1 to 291)
  AUTHORS   Arbi,M., Pefani,D.E., Kyrousi,C., Lalioti,M.E., Kalogeropoulou,A.,
            Papanastasiou,A.D., Taraviras,S. and Lygerou,Z.
  TITLE     GemC1 controls multiciliogenesis in the airway epithelium
  JOURNAL   EMBO Rep 17 (3), 400-413 (2016)
   PUBMED   26882546
  REMARK    GeneRIF: GemC1 directly transactivates the promoters of MCIDAS and
            FOXJ1.
REFERENCE   8  (residues 1 to 291)
  AUTHORS   Kyrousi,C., Arbi,M., Pilz,G.A., Pefani,D.E., Lalioti,M.E.,
            Ninkovic,J., Gotz,M., Lygerou,Z. and Taraviras,S.
  TITLE     Mcidas and GemC1 are key regulators for the generation of
            multiciliated ependymal cells in the adult neurogenic niche
  JOURNAL   Development 142 (21), 3661-3674 (2015)
   PUBMED   26395491
  REMARK    GeneRIF: Results suggest that Mcidas and GemC1 are key players in
            the generation of multiciliated ependymal cells of the adult
            neurogenic niche.
REFERENCE   9  (residues 1 to 291)
  AUTHORS   Wu,J., Bao,J., Kim,M., Yuan,S., Tang,C., Zheng,H., Mastick,G.S.,
            Xu,C. and Yan,W.
  TITLE     Two miRNA clusters, miR-34b/c and miR-449, are essential for normal
            brain development, motile ciliogenesis, and spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (28), E2851-E2857 (2014)
   PUBMED   24982181
REFERENCE   10 (residues 1 to 291)
  AUTHORS   Balestrini,A., Cosentino,C., Errico,A., Garner,E. and Costanzo,V.
  TITLE     GEMC1 is a TopBP1-interacting protein required for chromosomal DNA
            replication
  JOURNAL   Nat Cell Biol 12 (5), 484-491 (2010)
   PUBMED   20383140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154565.2, AK160719.1 and BC086669.1.
            
            Transcript Variant: This variant (3) has a shorter 5' UTR, lacks an
            exon in the 5' coding region and initiates translation at an
            alternate start codon compared to variant 1. The encoded protein
            (isoform 3) has a distinct N-terminus and is shorter than isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160719.1, BY712921.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849387,
                                           SAMN01164133 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.56 cM"
     Protein         1..291
                     /product="geminin coiled-coil domain-containing protein 1
                     isoform 3"
                     /note="geminin coiled-coil domain-containing protein 1"
                     /calculated_mol_wt=33106
     Region          31..91
                     /region_name="GemC1_CC"
                     /note="central coiled-coil domain of geminin coiled-coil
                     domain-containing protein 1; cd22588"
                     /db_xref="CDD:439142"
     Site            order(31,34..35,37..38,41..42,44..45,48..49,51..52,55..56,
                     58..59,62,66,69,72)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:439142"
     CDS             1..291
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /coded_by="NM_001285918.1:260..1135"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS88907.1"
                     /db_xref="GeneID:239789"
                     /db_xref="MGI:MGI:2685452"
ORIGIN      
        1 mritdwatrg ygrccvpesp selsfpvlds csweeaqlss qlyrnkqlqd tllqkeeela
       61 rlheennhlr qylnstlvkr leekakklls sdefskvfgk lrkekrkpke hrhspaeipq
      121 fktakrnlst efsnceeqpg phvdpwvlqt lglkdlntid dtlpanysat tshpravpsi
      181 sslfvhdang yanvprdlhl dyvgqgthgs httsihqedc hsfprlsnpp vrvqtlpyht
      241 advspnktem afstslsphc nvkthsfhqg qafvrrdeeg gwkftwvpkq t
//
LOCUS       NP_001289082             479 aa            linear   ROD 27-AUG-2025
DEFINITION  transcriptional regulator ERG isoform 3 [Mus musculus].
ACCESSION   NP_001289082 XP_006522961 XP_006523229
VERSION     NP_001289082.1
DBSOURCE    REFSEQ: accession NM_001302153.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Yamashita,T., Kaplan,U., Chakraborty,A., Marden,G., Gritli,S.,
            Roh,D., Bujor,A., Trojanowski,M., Ligresti,G., Browning,J.L. and
            Trojanowska,M.
  TITLE     ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis
  JOURNAL   Arthritis Rheumatol 76 (11), 1645-1657 (2024)
   PUBMED   38965683
  REMARK    GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
REFERENCE   5  (residues 1 to 479)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
REFERENCE   6  (residues 1 to 479)
  AUTHORS   Fan,C.M., Kuwana,E., Bulfone,A., Fletcher,C.F., Copeland,N.G.,
            Jenkins,N.A., Crews,S., Martinez,S., Puelles,L., Rubenstein,J.L.
            and Tessier-Lavigne,M.
  TITLE     Expression patterns of two murine homologs of Drosophila
            single-minded suggest possible roles in embryonic patterning and in
            the pathogenesis of Down syndrome
  JOURNAL   Mol Cell Neurosci 7 (1), 1-16 (1996)
   PUBMED   8812055
  REMARK    Erratum:[Mol Cell Neurosci 1996 Jun;7(6):519]
REFERENCE   7  (residues 1 to 479)
  AUTHORS   Mjaatvedt,A.E., Cabin,D.E., Cole,S.E., Long,L.J., Breitwieser,G.E.
            and Reeves,R.H.
  TITLE     Assessment of a mutation in the H5 domain of Girk2 as a candidate
            for the weaver mutation
  JOURNAL   Genome Res 5 (5), 453-463 (1995)
   PUBMED   8808466
REFERENCE   8  (residues 1 to 479)
  AUTHORS   Rivera,R.R., Stuiver,M.H., Steenbergen,R. and Murre,C.
  TITLE     Ets proteins: new factors that regulate immunoglobulin heavy-chain
            gene expression
  JOURNAL   Mol Cell Biol 13 (11), 7163-7169 (1993)
   PUBMED   8413305
REFERENCE   9  (residues 1 to 479)
  AUTHORS   Mjaatvedt,A.E., Citron,M.P. and Reeves,R.H.
  TITLE     High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and
            Erg on distal mouse chromosome 16
  JOURNAL   Genomics 17 (2), 382-386 (1993)
   PUBMED   8406490
REFERENCE   10 (residues 1 to 479)
  AUTHORS   Reddy,E.S., Rao,V.N. and Papas,T.S.
  TITLE     The erg gene: a human gene related to the ets oncogene
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6131-6135 (1987)
   PUBMED   3476934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB639043.1, AK142379.1, AK078113.1, AC154691.3 and BP753340.1.
            
            On or before Oct 4, 2014 this sequence version replaced
            XP_006522961.1, XP_006523229.1.
            
            Transcript Variant: This variant (3) uses a downstream alternate
            5'-terminal exon which reflects use of an alternate promoter
            supported by epigenetic data, compared to variant 1. The encoded
            isoform (3) is shorter and has a distinct N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142379.1, SRR13422586.321886.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.04 cM"
     Protein         1..479
                     /product="transcriptional regulator ERG isoform 3"
                     /note="transcriptional regulator ERG; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related"
                     /calculated_mol_wt=53713
     Region          115..198
                     /region_name="SAM_superfamily"
                     /note="SAM (Sterile alpha motif); cl15755"
                     /db_xref="CDD:472832"
     Region          310..393
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..479
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /coded_by="NM_001302153.1:104..1543"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS79493.1"
                     /db_xref="GeneID:13876"
                     /db_xref="MGI:MGI:95415"
ORIGIN      
        1 mastikeals vvsedqslfe caygtphlak temtassssd ygqtskmspr vpqqdwlsqa
       61 parvtikmec npsqvngsrn spdecsvnkg gkmvgspdtv gmsygsymee khvpppnmtt
      121 nerrvivpad ptlwstdhvr qwlewavkey glldvdvllf qnidgkelck mtkddfqrlt
      181 psynadills hlhylretpl phltsddvdk alqnsprlmh arntggaafi fpntsvypea
      241 tqrittrpdl pyepprrsaw tghshltpqs kaaqpspsav pktedqrpql dpyqilgpts
      301 srlanpgsgq iqlwqfllel lsdssnsnci twegtngefk mtdpdevarr wgerkskpnm
      361 nydklsralr yyydknimtk vhgkryaykf dfhgiaqalq phppesslyk ypsdlpymgs
      421 yhahpqkmnf vsphppalpv tsssffaspn pywnsptggi ypntrlpash mpshlgtyy
//
LOCUS       NP_001405741             165 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 8 [Mus musculus].
ACCESSION   NP_001405741 XP_006526290
VERSION     NP_001405741.1
DBSOURCE    REFSEQ: accession NM_001418812.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 165)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 165)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 165)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 165)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 165)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 165)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 165)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 165)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 165)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 165)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            On Mar 23, 2023 this sequence version replaced XP_006526290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1022464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..165
                     /product="COMM domain-containing protein 10 isoform 8"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=18282
     Region          15..85
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..165
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418812.1:39..536"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 maasaalilp espsmkkavp linaidtgrf prllsrilqk lhlkletvgw qlnlqmahsa
       61 qaklqspqav lqlgvskeda kfqtvssdhi hptsptprst sphpnyassf icptwrkfsw
      121 nsitrscsis ttswrpykrs wtpshdvled wlpspshsgh ltlsh
//
LOCUS       NP_001405936             312 aa            linear   ROD 27-AUG-2025
DEFINITION  low affinity immunoglobulin gamma Fc region receptor II-b isoform 4
            precursor [Mus musculus].
ACCESSION   NP_001405936
VERSION     NP_001405936.1
DBSOURCE    REFSEQ: accession NM_001419007.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 312)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 312)
  AUTHORS   Bennion,K.B., Miranda R Bazzano,J., Liu,D., Wagener,M., Paulos,C.M.
            and Ford,M.L.
  TITLE     Macrophage-derived Fgl2 dampens antitumor immunity through
            regulation of FcgammaRIIB+CD8+ T cells in melanoma
  JOURNAL   JCI Insight 10 (6), e182563 (2025)
   PUBMED   40125553
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 312)
  AUTHORS   Santana,S., Papillion,A., Foote,J.B., Bachus,H., Leon,B., De
            Miguel,C. and Ballesteros-Tato,A.
  TITLE     Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents
            Autoantibody Responses in Systemic Lupus Erythematosus via
            Regulatory T Cell-independent Depletion of T Follicular Helper
            Cells
  JOURNAL   J Immunol 213 (8), 1053-1060 (2024)
   PUBMED   39195194
REFERENCE   4  (residues 1 to 312)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 312)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 312)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (residues 1 to 312)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (residues 1 to 312)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (residues 1 to 312)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (residues 1 to 312)
  AUTHORS   Dickles,H.B., Ahmed,A. and Sachs,D.H.
  TITLE     B-lymphocyte Fc receptor-associated non-H-2 antigens are determined
            by a single polymorphic locus which is linked to the Mls locus
  JOURNAL   J Exp Med 146 (6), 1678-1692 (1977)
   PUBMED   303687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115959.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51629.1, SRR13422598.709828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.02 cM"
     Protein         1..312
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b isoform 4 precursor"
                     /note="low affinity immunoglobulin gamma Fc region
                     receptor II; fc-gamma RII; fc-gamma-RIIB; fc gamma
                     receptor IIB; lymphocyte antigen 17; igG Fc receptor II
                     beta; Fc-gamma-RII; Fc gamma RIIB; FcgammaRIIB; low
                     affinity immunoglobulin gamma Fc region receptor II-b"
                     /calculated_mol_wt=30671
     sig_peptide     1..39
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4397
     Region          46..124
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          63..67
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409410"
     Region          77..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409410"
     Region          92..96
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409410"
     Region          106..111
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409410"
     Region          117..120
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409410"
     Region          128..210
                     /region_name="Ig2_FcgammaR_like"
                     /note="Second immunoglobulin (Ig)-like domain of
                     Fcgamma-receptors (FcgammaRs), and similar domains;
                     cd05753"
                     /db_xref="CDD:409411"
     Site            order(128,151,157..158)
                     /site_type="other"
                     /note="Fc binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          128..132
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409411"
     Region          137..139
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409411"
     Site            order(141..143,152,157,196)
                     /site_type="other"
                     /note="pentraxin binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          143..150
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409411"
     Region          157..163
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409411"
     Region          166..171
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409411"
     Region          175..179
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409411"
     Region          189..194
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409411"
     Region          200..210
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409411"
     CDS             1..312
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /coded_by="NM_001419007.1:81..1019"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 5"
                     /db_xref="GeneID:14130"
                     /db_xref="MGI:MGI:95499"
ORIGIN      
        1 mgilpfllip mesnwtvhvf srtlchmllw tavlnlaagt hdlpkavvkl eppwiqvlke
       61 dtvtltcegt hnpgnsstqw fhngrsirsq vqasytfkat vndsgeyrcq meqtrlsdpv
      121 dlgvisdwll lqtpqlvfle getitlrchs wrnkllnris ffhneksvry hhyssnfsip
      181 kanhshsgdy yckgslgrtl hqskpvtitv qgpkssrslp vltivaavtg iavaaiviil
      241 vslvylkkkq vpalpgnpdh remgetlpee vdnppdleea akteaentit ysllkhpeal
      301 deetehdyqn hi
//
LOCUS       NP_038488                562 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1D adrenergic receptor [Mus musculus].
ACCESSION   NP_038488
VERSION     NP_038488.4
DBSOURCE    REFSEQ: accession NM_013460.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 562)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 562)
  AUTHORS   Hirsch,S.J., Budig,A., Husam,S. and Birklein,F.
  TITLE     Aged females unilaterally hypersensitize, lack descending
            inhibition, and overexpress alpha1D adrenergic receptors in a
            murine posttraumatic chronic pain model
  JOURNAL   Pain 165 (9), 1966-1977 (2024)
   PUBMED   38408277
  REMARK    GeneRIF: Aged females unilaterally hypersensitize, lack descending
            inhibition, and overexpress alpha1D adrenergic receptors in a
            murine posttraumatic chronic pain model.
REFERENCE   3  (residues 1 to 562)
  AUTHORS   Sandroni,P.B., Schroder,M.A., Hawkins,H.T., Bailon,J.D., Huang,W.,
            Hagen,J.T., Montgomery,M., Hong,S.J., Chin,A.L., Zhang,J.,
            Rodrigo,M.C., Kim,B., Simpson,P.C., Schisler,J.C., Ellis,J.M.,
            Fisher-Wellman,K.H. and Jensen,B.C.
  TITLE     The alpha-1A adrenergic receptor regulates mitochondrial oxidative
            metabolism in the mouse heart
  JOURNAL   J Mol Cell Cardiol 187, 101-117 (2024)
   PUBMED   38331556
  REMARK    GeneRIF: The alpha-1A adrenergic receptor regulates mitochondrial
            oxidative metabolism in the mouse heart.
REFERENCE   4  (residues 1 to 562)
  AUTHORS   Konstandi,M., Kypreos,K.E., Matsubara,T., Xepapadaki,E., Shah,Y.M.,
            Krausz,K., Andriopoulou,C.E., Kofinas,A. and Gonzalez,F.J.
  TITLE     Adrenoceptor-related decrease in serum triglycerides is independent
            of PPARalpha activation
  JOURNAL   FEBS J 286 (21), 4328-4341 (2019)
   PUBMED   31230416
  REMARK    GeneRIF: the findings of the present study indicate that
            stimulation of a1 - and b1/2 -ARs markedly reduced serum TG
            steady-state levels as a result of alterations in TG synthesis,
            uptake, transport, hydrolysis, metabolism and clearance, an effect
            induced by PPARa independent mechanisms
REFERENCE   5  (residues 1 to 562)
  AUTHORS   Musayeva,A., Manicam,C., Steege,A., Brochhausen,C., Straub,B.K.,
            Bell,K., Pfeiffer,N. and Gericke,A.
  TITLE     Role of alpha1-adrenoceptor subtypes on corneal epithelial
            thickness and cell proliferation in mice
  JOURNAL   Am J Physiol Cell Physiol 315 (5), C757-C765 (2018)
   PUBMED   30257104
  REMARK    GeneRIF: no alpha1-AR mRNA was detected in the stroma, and only
            alpha1B-AR mRNA was found in the Descemet endothelial complex.
            Remarkably, corneal epithelial thickness and mean epithelial cell
            size were reduced in alpha1A-AR(-/-) mice. Our findings suggest
            that the alpha1A-AR exerts growth effects in mouse corneal
            epithelial cells.
REFERENCE   6  (residues 1 to 562)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
REFERENCE   7  (residues 1 to 562)
  AUTHORS   Milligan,G., Svoboda,P. and Brown,C.M.
  TITLE     Why are there so many adrenoceptor subtypes?
  JOURNAL   Biochem Pharmacol 48 (6), 1059-1071 (1994)
   PUBMED   7945399
  REMARK    Review article
REFERENCE   8  (residues 1 to 562)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
REFERENCE   9  (residues 1 to 562)
  AUTHORS   Oakey,R.J., Caron,M.G., Lefkowitz,R.J. and Seldin,M.F.
  TITLE     Genomic organization of adrenergic and serotonin receptors in the
            mouse: linkage mapping of sequence-related genes provides a method
            for examining mammalian chromosome evolution
  JOURNAL   Genomics 10 (2), 338-344 (1991)
   PUBMED   1676978
REFERENCE   10 (residues 1 to 562)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831731.6.
            
            On Jul 14, 2006 this sequence version replaced NP_038488.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.5733.1,
                                           SRR7345562.1676651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.5 cM"
     Protein         1..562
                     /product="alpha-1D adrenergic receptor"
                     /note="alpha-1D adrenoceptor; alpha-1D adrenoreceptor;
                     alpha-1A adrenergic receptor"
                     /calculated_mol_wt=59388
     Region          91..407
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          93..117
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          126..148
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          164..186
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          209..225
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          246..269
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          341..363
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          375..400
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..562
                     /gene="Adra1d"
                     /gene_synonym="Adra-1; Adra1; Adra1a; alpha1D-AR; Gpcr8;
                     Spr8; [a]1d"
                     /coded_by="NM_013460.5:330..2018"
                     /db_xref="CCDS:CCDS16764.1"
                     /db_xref="GeneID:11550"
                     /db_xref="MGI:MGI:106673"
ORIGIN      
        1 mtfrdilsvt fegprassst ggsgagggag tvgpegpavg gvpgatggsa vvgtgsgedn
       61 qsstaeagaa asgevngsaa vgglvvsaqg vgvgvflaaf iltavagnll vilsvacnrh
      121 lqtvtnyfiv nlavadllls aavlpfsatm evlgfwafgr tfcdvwaavd vlcctasils
      181 lctisvdryv gvrhslkypa imterkaaai lallwavalv vsvgpllgwk epvppderfc
      241 giteevgyai fssvcsfylp mavivvmycr vyvvarsttr sleagikrep gkasevvlri
      301 hcrgaatsak gnpgtqsskg htlrsslsvr llkfsrekka aktlaivvgv fvlcwfpfff
      361 vlplgslfpq lkpsegvfkv ifwlgyfnsc vnpliypcss refkraflrl lrcqcrrrrr
      421 rlwrvyghhw rastgdprsd capspriapp gaplaltahp gpgsvdtpea qasvsgrrkp
      481 asalrewrll gplqrpttql rakvsslshk frsggarrae tacalrseve avslnvpqdg
      541 aeavicqaye pgdlsnlret di
//
LOCUS       NP_001272460             200 aa            linear   ROD 27-AUG-2025
DEFINITION  transducin-like enhancer protein 1 isoform d [Mus musculus].
ACCESSION   NP_001272460
VERSION     NP_001272460.1
DBSOURCE    REFSEQ: accession NM_001285531.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 200)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 200)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 200)
  AUTHORS   Simonson,L., Oldham,E. and Chang,H.
  TITLE     Overactive Wnt5a signaling disrupts hair follicle polarity during
            mouse skin development
  JOURNAL   Development 149 (22) (2022)
   PUBMED   36305473
REFERENCE   4  (residues 1 to 200)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   5  (residues 1 to 200)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 200)
  AUTHORS   Lepourcelet,M. and Shivdasani,R.A.
  TITLE     Characterization of a novel mammalian Groucho isoform and its role
            in transcriptional regulation
  JOURNAL   J Biol Chem 277 (49), 47732-47740 (2002)
   PUBMED   12359720
  REMARK    GeneRIF: Grg1-S may operate in conjunction with beta-catenin and
            Tcf factors to regulate vertebrate gut epithelial cell
            differentiation
REFERENCE   7  (residues 1 to 200)
  AUTHORS   Husain,J., Lo,R., Grbavec,D. and Stifani,S.
  TITLE     Affinity for the nuclear compartment and expression during cell
            differentiation implicate phosphorylated Groucho/TLE1 forms of
            higher molecular mass in nuclear functions
  JOURNAL   Biochem J 317 (Pt 2) (Pt 2), 523-531 (1996)
   PUBMED   8713081
REFERENCE   8  (residues 1 to 200)
  AUTHORS   Ishibashi,M., Ang,S.L., Shiota,K., Nakanishi,S., Kageyama,R. and
            Guillemot,F.
  TITLE     Targeted disruption of mammalian hairy and Enhancer of split
            homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix
            factors, premature neurogenesis, and severe neural tube defects
  JOURNAL   Genes Dev 9 (24), 3136-3148 (1995)
   PUBMED   8543157
REFERENCE   9  (residues 1 to 200)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   10 (residues 1 to 200)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044642.1 and AK046402.1.
            
            Transcript Variant: This variant (4) lacks several exons in the
            central and 3' coding regions, but contains an alternate 3'
            terminal exon, and it thus differs in its 3' coding region and 3'
            UTR, compared to variant 1. The encoded isoform (d) has a distinct
            C-terminus and is significantly shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046402.1, BI851955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 36.06 cM"
     Protein         1..200
                     /product="transducin-like enhancer protein 1 isoform d"
                     /note="transducin-like enhancer of split 1, homolog of
                     Drosophila E(spl); transducin-like enhancer protein 1;
                     groucho-related protein 1; transducin-like enhancer of
                     split 4 (homolog of Drosophila E(spl)) - like"
                     /calculated_mol_wt=22307
     Region          18..133
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     CDS             1..200
                     /gene="Tle1"
                     /gene_synonym="C230057C06Rik; Estm14; Grg-1; Grg1; Tle4l"
                     /coded_by="NM_001285531.1:889..1491"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS71407.1"
                     /db_xref="GeneID:21885"
                     /db_xref="MGI:MGI:104636"
ORIGIN      
        1 mfpqsrhptp hqaagqpfkf tipesldrik eefqflqaqy hslklecekl asektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntica qvipflsqeh qqqvaqaver akqvtmaeln
      121 aiigqqqlqa qhlshghgpp vpltphpsgl qppgipplgg sasllalssa lsgqshlaik
      181 ddkkhhdaer hrgerpgkpd
//
LOCUS       NP_001277985             206 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform b [Mus musculus].
ACCESSION   NP_001277985 XP_006499115
VERSION     NP_001277985.1
DBSOURCE    REFSEQ: accession NM_001291056.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            On Mar 22, 2014 this sequence version replaced XP_006499115.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon but
            contains a different in-frame exon in the central coding region,
            compared to variant 1. The encoded isoform (b) is the same length
            but contains an alternate internal segment, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.135825.1,
                                           SRR7345562.3023586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..206
                     /product="synaptosomal-associated protein 25 isoform b"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=23205
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..142
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          143..201
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(143,145..146,149..154,156..157,160..161,163..165,
                     167..168,171..172,174..175,177..182,184..185,188,191,195,
                     198,201)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            174
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     CDS             1..206
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001291056.2:210..830"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS71153.1"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqldrv
       61 eegmnhinqd mkeaeknlkd lgkccglfic pcnklkssda ykkawgnnqd gvvasqparv
      121 vdereqmais ggfirrvtnd arenemdenl eqvsgiignl rhmaldmgne idtqnrqidr
      181 imekadsnkt rideanqrat kmlgsg
//
LOCUS       NP_031453                131 aa            linear   ROD 27-AUG-2025
DEFINITION  agouti-related protein precursor [Mus musculus].
ACCESSION   NP_031453
VERSION     NP_031453.1
DBSOURCE    REFSEQ: accession NM_007427.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 131)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 131)
  AUTHORS   Senol,E., Wang,M., Xin,Y., Jiao,Z., Mohammad,H., Yeo,X.Y., Si,T.,
            Young,D.M., Huang,H., Wang,Y., Li,Q., Jung,S.Y., Xu,X., Zhang,P.
            and Fu,Y.
  TITLE     Brain-wide input-output analysis of tuberal nucleus somatostatin
            neurons reveals hierarchical circuits for orchestrating feeding
            behavior
  JOURNAL   Nat Commun 16 (1), 5627 (2025)
   PUBMED   40593512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 131)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   4  (residues 1 to 131)
  AUTHORS   Park,B.S., Yang,H.R., Kang,H., Kim,K.K., Kim,Y.T., Yang,S. and
            Kim,J.G.
  TITLE     alpha2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons:
            Impact on Food Intake and Energy Expenditure
  JOURNAL   Int J Mol Sci 26 (8), 3590 (2025)
   PUBMED   40332078
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 131)
  AUTHORS   Ilnytska,O. and Argyropoulos,G.
  TITLE     The role of the Agouti-Related Protein in energy balance regulation
  JOURNAL   Cell Mol Life Sci 65 (17), 2721-2731 (2008)
   PUBMED   18470724
  REMARK    Review article
REFERENCE   6  (residues 1 to 131)
  AUTHORS   Mizuno,T.M. and Mobbs,C.V.
  TITLE     Hypothalamic agouti-related protein messenger ribonucleic acid is
            inhibited by leptin and stimulated by fasting
  JOURNAL   Endocrinology 140 (2), 814-817 (1999)
   PUBMED   9927310
REFERENCE   7  (residues 1 to 131)
  AUTHORS   Broberger,C., Johansen,J., Johansson,C., Schalling,M. and
            Hokfelt,T.
  TITLE     The neuropeptide Y/agouti gene-related protein (AGRP) brain
            circuitry in normal, anorectic, and monosodium glutamate-treated
            mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 15043-15048 (1998)
   PUBMED   9844012
REFERENCE   8  (residues 1 to 131)
  AUTHORS   Graham,M., Shutter,J.R., Sarmiento,U., Sarosi,I. and Stark,K.L.
  TITLE     Overexpression of Agrt leads to obesity in transgenic mice
  JOURNAL   Nat Genet 17 (3), 273-274 (1997)
   PUBMED   9354787
REFERENCE   9  (residues 1 to 131)
  AUTHORS   Ollmann,M.M., Wilson,B.D., Yang,Y.K., Kerns,J.A., Chen,Y., Gantz,I.
            and Barsh,G.S.
  TITLE     Antagonism of central melanocortin receptors in vitro and in vivo
            by agouti-related protein
  JOURNAL   Science 278 (5335), 135-138 (1997)
   PUBMED   9311920
  REMARK    Erratum:[Science 1998 Sep 11;281(5383):1615]
REFERENCE   10 (residues 1 to 131)
  AUTHORS   Shutter,J.R., Graham,M., Kinsey,A.C., Scully,S., Luthy,R. and
            Stark,K.L.
  TITLE     Hypothalamic expression of ART, a novel gene related to agouti, is
            up-regulated in obese and diabetic mutant mice
  JOURNAL   Genes Dev 11 (5), 593-602 (1997)
   PUBMED   9119224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CO044337.1, BC079902.1 and
            AK138796.1.
            
            Summary: This gene encodes a protein that regulates feeding
            behavior and plays a key role in the control of body weight. The
            encoded protein acts as an antagonist of melanocortin receptor
            signaling. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO044337.1, BC079902.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849376 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..131
                     /product="agouti-related protein precursor"
                     /note="agouti-related protein; orexigenic neuropeptide"
                     /calculated_mol_wt=12379
     Region          1..121
                     /region_name="Agouti"
                     /note="Agouti protein; smart00792"
                     /db_xref="CDD:197876"
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2071
     Site            81..82
                     /site_type="cleavage"
                     /note="Cleavage, by PCSK1.
                     /evidence=ECO:0000250|UniProtKB:O00253; propagated from
                     UniProtKB/Swiss-Prot (P56473.1)"
     mat_peptide     82..131
                     /product="Agouti-related protein. /id=PRO_0000001035"
                     /note="propagated from UniProtKB/Swiss-Prot (P56473.1)"
                     /calculated_mol_wt=5684
     Region          110..112
                     /region_name="Interaction with melanocortin receptors.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56473.1)"
     CDS             1..131
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /coded_by="NM_007427.3:211..606"
                     /db_xref="CCDS:CCDS22605.1"
                     /db_xref="GeneID:11604"
                     /db_xref="MGI:MGI:892013"
ORIGIN      
        1 mltamllscv lllalpptlg vqmgvaplkg irrpdqalfp efpglslngl kkttadraee
       61 vllqkaeala evldpqnres rsprrcvrlh esclgqqvpc cdpcatcycr ffnafcycrk
      121 lgtatnlcsr t
//
LOCUS       NP_001103736             137 aa            linear   ROD 27-AUG-2025
DEFINITION  vascular endothelial growth factor A, long form isoform 4 precursor
            [Mus musculus].
ACCESSION   NP_001103736
VERSION     NP_001103736.1
DBSOURCE    REFSEQ: accession NM_001110266.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 137)
  AUTHORS   Man,X., Usui,N., Doi,M. and Shimada,S.
  TITLE     Sex differences in placental structure and gene expression in ICR
            mice during embryonic development
  JOURNAL   Sci Rep 15 (1), 24067 (2025)
   PUBMED   40617958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 137)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   3  (residues 1 to 137)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 137)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (residues 1 to 137)
  AUTHORS   Bastide,A., Karaa,Z., Bornes,S., Hieblot,C., Lacazette,E., Prats,H.
            and Touriol,C.
  TITLE     An upstream open reading frame within an IRES controls expression
            of a specific VEGF-A isoform
  JOURNAL   Nucleic Acids Res 36 (7), 2434-2445 (2008)
   PUBMED   18304943
REFERENCE   6  (residues 1 to 137)
  AUTHORS   Huez,I., Bornes,S., Bresson,D., Creancier,L. and Prats,H.
  TITLE     New vascular endothelial growth factor isoform generated by
            internal ribosome entry site-driven CUG translation initiation
  JOURNAL   Mol Endocrinol 15 (12), 2197-2210 (2001)
   PUBMED   11731620
REFERENCE   7  (residues 1 to 137)
  AUTHORS   Tee,M.K. and Jaffe,R.B.
  TITLE     A precursor form of vascular endothelial growth factor arises by
            initiation from an upstream in-frame CUG codon
  JOURNAL   Biochem J 359 (Pt 1), 219-226 (2001)
   PUBMED   11563986
REFERENCE   8  (residues 1 to 137)
  AUTHORS   Meiron,M., Anunu,R., Scheinman,E.J., Hashmueli,S. and Levi,B.Z.
  TITLE     New isoforms of VEGF are translated from alternative initiation CUG
            codons located in its 5'UTR
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1053-1060 (2001)
   PUBMED   11352659
REFERENCE   9  (residues 1 to 137)
  AUTHORS   Claffey,K.P., Wilkison,W.O. and Spiegelman,B.M.
  TITLE     Vascular endothelial growth factor. Regulation by cell
            differentiation and activated second messenger pathways
  JOURNAL   J Biol Chem 267 (23), 16317-16322 (1992)
   PUBMED   1644816
REFERENCE   10 (residues 1 to 137)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU920197.1, AC127690.4,
            BQ554097.1, BC061468.1 and AK031905.1.
            
            Summary: This gene is a member of the PDGF/VEGF growth factor
            family. It encodes a heparin-binding protein, which exists as a
            disulfide-linked homodimer. This growth factor induces
            proliferation and migration of vascular endothelial cells, and is
            essential for both physiological and pathological angiogenesis.
            Disruption of this gene in mice resulted in abnormal embryonic
            blood vessel formation. This gene is upregulated in many known
            tumors and its expression is correlated with tumor stage and
            progression. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. There is also
            evidence for alternative translation initiation from upstream
            non-AUG (CUG) codons resulting in additional isoforms. A recent
            study showed that a C-terminally extended isoform is produced by
            use of an alternative in-frame translation termination codon via a
            stop codon readthrough mechanism, and that this isoform is
            antiangiogenic. Expression of some isoforms derived from the AUG
            start codon is regulated by a small upstream open reading frame,
            which is located within an internal ribosome entry site.[provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The resulting isoform (4) has
            a distinct and shorter N-terminus, compared to isoform 1. This
            variant has transcript support, but the protein is predicted.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ554097.1, SRR1660825.369261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.79 cM"
     Protein         1..137
                     /product="vascular endothelial growth factor A, long form
                     isoform 4 precursor"
                     /note="vascular permeability factor; vascular endothelial
                     growth factor A, long form"
                     /calculated_mol_wt=15674
     mat_peptide     23..137
                     /product="vascular endothelial growth factor A, long form
                     isoform 4"
                     /calculated_mol_wt=13706
     Region          <27..54
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family domain; PDGF is a potent
                     activator for cells of mesenchymal origin; PDGF-A and
                     PDGF-B form AA and BB homodimers and an AB heterodimer;
                     VEGF is a potent mitogen in embryonic and...; cl00116"
                     /db_xref="CDD:444701"
     Region          89..137
                     /region_name="VEGF_C"
                     /note="VEGF heparin-binding domain; pfam14554"
                     /db_xref="CDD:405273"
     CDS             1..137
                     /gene="Vegfa"
                     /gene_synonym="L-VEGF; Vegf; Vpf"
                     /coded_by="NM_001110266.1:563..976"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:22339"
                     /db_xref="MGI:MGI:103178"
ORIGIN      
        1 magapgcpig vwlagslttv icslplqimr ikphqsqhig emsflqhsrc ecrpkkdrtk
       61 pekksvrgkg kgqkrkrkks rfkswsvhce pcserrkhlf vqdpqtckcs ckntdsrcka
      121 rqlelnertc rcdkprr
//
LOCUS       NP_598820                622 aa            linear   ROD 27-AUG-2025
DEFINITION  probable ATP-dependent RNA helicase DDX41 [Mus musculus].
ACCESSION   NP_598820
VERSION     NP_598820.2
DBSOURCE    REFSEQ: accession NM_134059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 622)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 622)
  AUTHORS   Stepanchick,E., Wilson,A., Sulentic,A.M., Choi,K., Hueneman,K.,
            Starczynowski,D.T. and Chlon,T.M.
  TITLE     DDX41 haploinsufficiency causes inefficient hematopoiesis under
            stress and cooperates with p53 mutations to cause hematologic
            malignancy
  JOURNAL   Leukemia 38 (8), 1787-1798 (2024)
   PUBMED   38937548
  REMARK    GeneRIF: DDX41 haploinsufficiency causes inefficient hematopoiesis
            under stress and cooperates with p53 mutations to cause hematologic
            malignancy.
REFERENCE   3  (residues 1 to 622)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 622)
  AUTHORS   Shinriki,S., Hirayama,M., Nagamachi,A., Yokoyama,A., Kawamura,T.,
            Kanai,A., Kawai,H., Iwakiri,J., Liu,R., Maeshiro,M., Tungalag,S.,
            Tasaki,M., Ueda,M., Tomizawa,K., Kataoka,N., Ideue,T., Suzuki,Y.,
            Asai,K., Tani,T., Inaba,T. and Matsui,H.
  TITLE     DDX41 coordinates RNA splicing and transcriptional elongation to
            prevent DNA replication stress in hematopoietic cells
  JOURNAL   Leukemia 36 (11), 2605-2620 (2022)
   PUBMED   36229594
REFERENCE   5  (residues 1 to 622)
  AUTHORS   Ma,J., Mahmud,N., Bosland,M.C. and Ross,S.R.
  TITLE     DDX41 is needed for pre- and postnatal hematopoietic stem cell
            differentiation in mice
  JOURNAL   Stem Cell Reports 17 (4), 879-893 (2022)
   PUBMED   35303436
  REMARK    GeneRIF: DDX41 is needed for pre- and postnatal hematopoietic stem
            cell differentiation in mice.
REFERENCE   6  (residues 1 to 622)
  AUTHORS   Zhang,Z., Bao,M., Lu,N., Weng,L., Yuan,B. and Liu,Y.J.
  TITLE     The E3 ubiquitin ligase TRIM21 negatively regulates the innate
            immune response to intracellular double-stranded DNA
  JOURNAL   Nat Immunol 14 (2), 172-178 (2013)
   PUBMED   23222971
  REMARK    GeneRIF: TRIM21 is an interferon-inducible E3 ligase that induces
            the Lys48-linked ubiquitination and degradation of DDX41 and
            negatively regulates the innate immune response to intracellular
            double-stranded DNA.
REFERENCE   7  (residues 1 to 622)
  AUTHORS   Parvatiyar,K., Zhang,Z., Teles,R.M., Ouyang,S., Jiang,Y.,
            Iyer,S.S., Zaver,S.A., Schenk,M., Zeng,S., Zhong,W., Liu,Z.J.,
            Modlin,R.L., Liu,Y.J. and Cheng,G.
  TITLE     The helicase DDX41 recognizes the bacterial secondary messengers
            cyclic di-GMP and cyclic di-AMP to activate a type I interferon
            immune response
  JOURNAL   Nat Immunol 13 (12), 1155-1161 (2012)
   PUBMED   23142775
REFERENCE   8  (residues 1 to 622)
  AUTHORS   Zhang,Z., Yuan,B., Bao,M., Lu,N., Kim,T. and Liu,Y.J.
  TITLE     The helicase DDX41 senses intracellular DNA mediated by the adaptor
            STING in dendritic cells
  JOURNAL   Nat Immunol 12 (10), 959-965 (2011)
   PUBMED   21892174
  REMARK    GeneRIF: DDX41 is an additional DNA sensor that depends on STING to
            sense pathogenic DNA.
            Erratum:[Nat Immunol. 2012 Feb;13(2):196]
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 622)
  AUTHORS   Nagamori,I., Yomogida,K., Adams,P.D., Sassone-Corsi,P. and
            Nojima,H.
  TITLE     Transcription factors, cAMP-responsive element modulator (CREM) and
            Tisp40, act in concert in postmeiotic transcriptional regulation
  JOURNAL   J Biol Chem 281 (22), 15073-15081 (2006)
   PUBMED   16595651
REFERENCE   10 (residues 1 to 622)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013586.1, AK151427.1, CX231996.1, BE864921.1 and CJ303880.1.
            
            On Dec 2, 2009 this sequence version replaced NP_598820.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011308.1, AK156957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     Protein         1..622
                     /product="probable ATP-dependent RNA helicase DDX41"
                     /EC_number="3.6.4.13"
                     /note="DEAD-box protein abstrakt; DEAD box protein 41;
                     DEAD (Asp-Glu-Ala-Asp) box polypeptide 41"
                     /calculated_mol_wt=69689
     Region          1..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJV9; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            9
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJV9; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Region          51..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VN6.2)"
     Region          181..209
                     /region_name="Q motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VN6.2)"
     Region          192..397
                     /region_name="DEADc_DDX41"
                     /note="DEAD-box helicase domain of DEAD box protein 41;
                     cd17951"
                     /db_xref="CDD:350709"
     Site            order(200..201,203..205,208,226..233)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350709"
     Region          344..347
                     /region_name="DEAD box.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00541"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VN6.2)"
     Region          408..536
                     /region_name="SF2_C_DEAD"
                     /note="C-terminal helicase domain of the DEAD box
                     helicases; cd18787"
                     /db_xref="CDD:350174"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJV9; propagated from
                     UniProtKB/Swiss-Prot (Q91VN6.2)"
     Site            order(495,497,522,525..526)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350174"
     CDS             1..622
                     /gene="Ddx41"
                     /gene_synonym="2900024F02Rik; ABS"
                     /coded_by="NM_134059.2:152..2020"
                     /db_xref="CCDS:CCDS26549.1"
                     /db_xref="GeneID:72935"
                     /db_xref="MGI:MGI:1920185"
ORIGIN      
        1 medseperkr aradeatagg srsedededd edyvpyvplr qrrqlllqkl lqrrrkgate
       61 eeqqdsgsep rgdeddiplg pqsnvslldq hqhlkekaea rkesakekql keeekilesv
      121 aegralmsvk emakgitydd piktswtppr yvlsmseerh ervrkkyhil vegdgipppi
      181 ksfkemkfpa ailrglkkkg ilhptpiqiq giptilsgrd migiaftgsg ktlvftlpvi
      241 mfcleqekrl pfskregpyg liicpsrela rqthgileyy crllqedssp llrcalcigg
      301 msvkeqmeti rhgvhmmvat pgrlmdllqk kmvsldicry laldeadrmi dmgfegdirt
      361 ifsyfkgqrq tllfsatmpk kiqnfaksal vkpvtinvgr agaasldviq eveyvkeeak
      421 mvylleclqk tpppvlifae kkadvdaihe ylllkgveav aihggkdqee rtkaieafre
      481 gkkdvlvatd vaskgldfpa iqhvinydmp eeienyvhri grtgrsgntg iattfinkac
      541 desvlmdlka llleakqkvp pvlqvlhcgd esmldigger gcafcgglgh ritdcpklea
      601 mqtkqvsnig rkdylahssm df
//
LOCUS       NP_001409071             823 aa            linear   ROD 27-AUG-2025
DEFINITION  hypoxia-inducible factor 1-alpha isoform 5 [Mus musculus].
ACCESSION   NP_001409071 XP_006515541
VERSION     NP_001409071.1
DBSOURCE    REFSEQ: accession NM_001422142.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 823)
  AUTHORS   Sanchez-Garcia,M.A., Lara-Urena,N., March-Diaz,R., Ortega-de San
            Luis,C., Quinones-Canete,S., Mora-Romero,B., Barba-Reyes,J.M.,
            Cabello-Rivera,D., Romero-Molina,C., Heras-Garvin,A., Navarro,V.,
            Lopez-Barneo,J., Vizuete,M., Vitorica,J., Munoz-Cabello,A.M.,
            Munoz-Manchado,A.B., Cokman,M.E., Rosales-Nieves,A.E. and
            Pascual,A.
  TITLE     Inactivation of the PHD3-FOXO3 axis blunts the type I interferon
            response in microglia and ameliorates Alzheimer's disease
            progression
  JOURNAL   Sci Adv 11 (22), eadu2244 (2025)
   PUBMED   40435260
REFERENCE   2  (residues 1 to 823)
  AUTHORS   Pekayvaz,K., Kilani,B., Joppich,M., Eivers,L., Brambs,S.,
            Knottenberg,V., Akgol,S., Yue,K., Li,L., Martinez-Navarro,A.,
            Kaiser,R., Meissner,N., Schulz,H., Belz,L., Akhalkatsi,A.,
            Stockhausen,S., Mueller,T.T., Millonig,S., Hartelt,L., Gold,C.,
            Janjic,A., Polewka,V., Wendler,F., Droste Zu Senden,A., Titova,A.,
            Leunig,A., Voelkl,M., Engelmann,B., Hernandez Petzsche,M.R.,
            Boeckh-Behrens,T., Liebig,T., Winning,S., Fandrey,J., Dichgans,M.,
            Enard,W., Zimmer,R., Tiedt,S., Massberg,S., Nicolai,L. and Stark,K.
  TITLE     Immunothrombolytic monocyte-neutrophil axes dominate the
            single-cell landscape of human thrombosis and correlate with
            thrombus resolution
  JOURNAL   Immunity 58 (5), 1343-1358 (2025)
   PUBMED   40280129
REFERENCE   3  (residues 1 to 823)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 823)
  AUTHORS   Ruan,W., Li,T., Bang,I.H., Lee,J., Deng,W., Ma,X., Luo,C., Du,F.,
            Yoo,S.H., Kim,B., Li,J., Yuan,X., Figarella,K., An,Y.A., Wang,Y.Y.,
            Liang,Y., DeBerge,M., Zhang,D., Zhou,Z., Wang,Y., Gorham,J.M.,
            Seidman,J.G., Seidman,C.E., Aranki,S.F., Nair,R., Li,L., Narula,J.,
            Zhao,Z., Gorfe,A.A., Muehlschlegel,J.D., Tsai,K.L. and
            Eltzschig,H.K.
  TITLE     BMAL1-HIF2A heterodimer modulates circadian variations of
            myocardial injury
  JOURNAL   Nature 641 (8064), 1017-1028 (2025)
   PUBMED   40269168
REFERENCE   5  (residues 1 to 823)
  AUTHORS   Guo,C., Niu,Y., Pan,X., Sharma,D., Lau,E., Jin,Y., Luxardi,G.,
            Amanullah,M., Lo,K., Moshiri,A., Qian,J., Montaner,S. and Sodhi,A.
  TITLE     Hypoglycemia promotes inner blood-retinal barrier breakdown and
            retinal vascular leakage in diabetic mice
  JOURNAL   Sci Transl Med 17 (796), eadq5355 (2025)
   PUBMED   40305573
REFERENCE   6  (residues 1 to 823)
  AUTHORS   Li,H., Ko,H.P. and Whitlock,J.P.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 823)
  AUTHORS   Wood,S.M., Gleadle,J.M., Pugh,C.W., Hankinson,O. and Ratcliffe,P.J.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 823)
  AUTHORS   Semenza,G.L., Rue,E.A., Iyer,N.V., Pang,M.G. and Kearns,W.G.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 823)
  AUTHORS   Wenger,R.H., Rolfs,A., Marti,H.H., Guenet,J.L. and Gassmann,M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 823)
  AUTHORS   Obara,N. and Takeda,M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Jun 6, 2023 this sequence version replaced XP_006515541.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.871961.1,
                                           SRR17784646.663546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..823
                     /product="hypoxia-inducible factor 1-alpha isoform 5"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=91886
     Region          14..84
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(19..20,22..24,27..28,30..31,56..57)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Region          22..31
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            order(33..34,36..37,40..41,44..45,56..58,61..62,65,68..69,
                     72)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          94..149
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          171..192
                     /region_name="Required for heterodimer formation with
                     ARNT. /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          255..340
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(256,260,266,279..282,308,313)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(276,280,288,291..292,320,322)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          381..418
                     /region_name="N-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            403
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          493..512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          531..575
                     /region_name="NTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            532
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          551..580
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:463274"
     Site            551
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            555
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          556..572
                     /region_name="C-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            564
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          576..782
                     /region_name="ID"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            576
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          580..671
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            589
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          694..721
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            706
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          715..718
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          783..823
                     /region_name="CTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          786..822
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     Site            800
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     CDS             1..823
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001422142.1:290..2761"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 megaggenek knrmsserrk eksrdaarsr rskesevfye lahqlplphn vsshldkasv
       61 mrltisylrv rklldaggld sedemkaqmd cfylkaldgf vmvltddgdm vyisdnvnky
      121 mgltqfeltg hsvfdfthpc dheemremlt hrngpvrkgk elntqrsffl rmkctltsrg
      181 rtmniksatw kvlhctghih vydtnsnqpq cgykkppmtc lvlicepiph psnieiplds
      241 ktflsrhsld mkfsycderi telmgyepee llgrsiyeyy haldsdhltk thhdmftkgq
      301 vttgqyrmla krggyvwvet qatviyntkn sqpqcivcvn yvvsgiiqhd lifslqqtes
      361 vlkpvessdm kmtqlftkve sedtsclfdk lkkepdaltl lapaagdtii sldfgsddte
      421 tedqqledvp lyndvmfpss neklninlam splpssetpk plrssadpal nqevalkles
      481 speslglsft mpqiqdqpas psdgstrqss pepnspseyc fdvdsdmvnv fklelveklf
      541 aedteaknpf stqdtdldle mlapyipmdd dfqlrsfdql splesnspsp psmstvtgfq
      601 qtqlqkptit atatttattd esktetkdnk edikiliasp sstqvpqett takasaysgt
      661 hsrtaspdra gkrvieqtdk ahprslnlsa tlnqrntvpe eelnpktias qnaqrkrkme
      721 hdgslfqaag igtllqqpgd captmslswk rvkgfisseq ngteqktiil ipsdlacrll
      781 gqsmdesglp qltsydcevn apiqgsrnll qgeellrald qvn
//
LOCUS       NP_444299                275 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 1 [Mus musculus].
ACCESSION   NP_444299
VERSION     NP_444299.1
DBSOURCE    REFSEQ: accession NM_053069.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 275)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 275)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 275)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 275)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 275)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 275)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 275)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 275)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 275)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 275)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 4 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028315.1, SRR13948564.3277512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..275
                     /product="autophagy protein 5 isoform 1"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=32271
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1Y0; propagated from
                     UniProtKB/Swiss-Prot (Q99J83.1)"
     Region          79..270
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..275
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_053069.7:244..1071"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23824.1"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mtddkdvlrd vwfgriptcf tlyqdeiter eaepyylllp rvsyltlvtd kvkkhfqkvm
       61 rqedvseiwf eyegtplkwh ypigllfdll asssalpwni tvhfksfpek dllhcpskda
      121 veahfmscmk eadalkhksq vinemqkkdh kqlwmglqnd rfdqfwainr klmeyppeen
      181 gfryipfriy qttterpfiq klfrpvaadg qlhtlgdllr evcpsavape dgekrsqvmi
      241 hgiepmletp lqwlsehlsy pdnflhisiv pqptd
//
LOCUS       NP_034640                182 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon beta precursor [Mus musculus].
ACCESSION   NP_034640
VERSION     NP_034640.1
DBSOURCE    REFSEQ: accession NM_010510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 182)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 182)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 182)
  AUTHORS   Lata,S., Yabaji,S.M., O'Connell,A.K., Gertje,H.P., Kirber,M.T.,
            Crossland,N.A. and Kramnik,I.
  TITLE     Protocol for 3D multiplexed fluorescent imaging of pulmonary TB
            lesions using Opal-TSA dyes for signal amplification
  JOURNAL   STAR Protoc 6 (1), 103640 (2025)
   PUBMED   39982826
REFERENCE   4  (residues 1 to 182)
  AUTHORS   Wei,W., Gao,X., Qian,J., Li,L., Zhao,C., Xu,L., Zhu,Y., Liu,Z.,
            Liu,N., Wang,X., Jin,Z., Liu,B., Xu,L., Dong,J., Zhang,S., Wang,J.,
            Zhang,Y., Yu,Y., Yan,Z., Yang,Y., Lu,J., Fang,Y., Yuan,N. and
            Wang,J.
  TITLE     Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal
            hematopoiesis and survival
  JOURNAL   J Clin Invest 135 (3), e177375 (2025)
   PUBMED   39589832
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 182)
  AUTHORS   Yang,T., Li,T., Xing,Y., Cao,M., Zhang,M., Leng,Q., Qiu,J.,
            Song,X., Chen,J., Hu,G. and Qian,Y.
  TITLE     Dietary nucleic acids promote oral tolerance through innate sensing
            pathways in mice
  JOURNAL   Nat Commun 15 (1), 9461 (2024)
   PUBMED   39487135
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 182)
  AUTHORS   Senda,T., Shimazu,T., Matsuda,S., Kawano,G., Shimizu,H.,
            Nakamura,K.T. and Mitsui,Y.
  TITLE     Three-dimensional crystal structure of recombinant murine
            interferon-beta
  JOURNAL   EMBO J 11 (9), 3193-3201 (1992)
   PUBMED   1505514
REFERENCE   7  (residues 1 to 182)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   8  (residues 1 to 182)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   9  (residues 1 to 182)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (residues 1 to 182)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772316.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: K00020.1, BC119395.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..182
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 41.91 cM"
     Protein         1..182
                     /product="interferon beta precursor"
                     /note="interferon 1da1"
                     /calculated_mol_wt=19735
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2410
     mat_peptide     22..182
                     /product="interferon beta"
                     /calculated_mol_wt=19735
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P70499; propagated from
                     UniProtKB/Swiss-Prot (P01575.1)"
     Region          27..173
                     /region_name="IFab"
                     /note="Interferon alpha, beta. Includes also interferon
                     omega and tau. Different from interferon gamma family.
                     Type I interferons(alpha, beta) belong to the larger
                     helical cytokine superfamily, which includes growth
                     hormones, interleukins, several...; cd00095"
                     /db_xref="CDD:238047"
     Site            order(29..30,33,36..37,40,43..44,96..97,99..100,102..103,
                     106,109..110,113..114,117)
                     /site_type="active"
                     /note="putative IFNAR-1 binding site [active]"
                     /db_xref="CDD:238047"
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:3360010; propagated from
                     UniProtKB/Swiss-Prot (P01575.1)"
     Site            order(51..58,60..62,66..67,136..137,139..140,143..144,
                     146..147,150..155)
                     /site_type="active"
                     /note="putative IFNAR-2 binding site [active]"
                     /db_xref="CDD:238047"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:3360010; propagated from
                     UniProtKB/Swiss-Prot (P01575.1)"
     Site            97
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238047"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:3360010; propagated from
                     UniProtKB/Swiss-Prot (P01575.1)"
     CDS             1..182
                     /gene="Ifnb1"
                     /gene_synonym="If1da1; Ifb; IFN-beta; IFNB"
                     /coded_by="NM_010510.2:73..621"
                     /db_xref="CCDS:CCDS18318.1"
                     /db_xref="GeneID:15977"
                     /db_xref="MGI:MGI:107657"
ORIGIN      
        1 mnnrwilhaa fllcfsttal sinykqlqlq ertnirkcqe lleqlngkin ltyradfkip
       61 memtekmqks ytafaiqeml qnvflvfrnn fsstgwneti vvrlldelhq qtvflktvle
      121 ekqeerltwe msstalhlks yywrvqrylk lmkynsyawm vvraeifrnf liirrltrnf
      181 qn
//
LOCUS       NP_001334498             472 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 4 [Mus musculus].
ACCESSION   NP_001334498
VERSION     NP_001334498.1
DBSOURCE    REFSEQ: accession NM_001347569.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 472)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 472)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 472)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 472)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 472)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 472)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 472)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 472)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 472)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            Transcript Variant: This variant (7) differs in the 5' UTR and uses
            an alternate in-frame exon in the 5' coding region, compared to
            variant 3. The encoded isoform (4) is shorter than isoform 3. Both
            variants 6 and 7 encode isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN02415130
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..472
                     /product="myocyte-specific enhancer factor 2C isoform 4"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=51037
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          96..153
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..472
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347569.2:327..1745"
                     /note="isoform 4 is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS84045.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kenkgsespd pdssyaltpr teekykkine
      121 efdnmikshk ipavpppsfe mpvtipvssh nslvysnpvs tlgnpnllpl ahpslqrnsm
      181 spgvthrpps agntgglmgg dltsgagtsa gngygnprns pgllvspgnl nkniqakspp
      241 pmnlgmnnrk pdlrvlippg skntmpsvse dvdlllnqri nnsqsaqsla tpvvsvatpt
      301 lpgqgmggyp saisttygte yslssadlss lsgfntasal hlgsvtgwqq qhlhnmppsa
      361 lsqlgactst hlsqssnlsl pstqslsiks epvspprdrt ttpsrypqht trheagrspv
      421 dslsscsssy dgsdredhrn efhspigltr pspderesps vkrmrlsegw at
//
LOCUS       NP_766409                959 aa            linear   ROD 27-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase 13 [Mus musculus].
ACCESSION   NP_766409 XP_484537 XP_917498 XP_993352
VERSION     NP_766409.2
DBSOURCE    REFSEQ: accession NM_172821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 959)
  AUTHORS   Hemati-Gourabi,M., Cao,T., Mills,A.E., Rice,E.P., Baur,L., Xu,X.,
            Fenske,W.K. and Chen,M.
  TITLE     Morphological regulation of wound repair astrocytes by leucine
            zipper-bearing kinase-AKT signaling after spinal cord injury
  JOURNAL   Exp Neurol 393, 115379 (2025)
   PUBMED   40680877
REFERENCE   2  (residues 1 to 959)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 959)
  AUTHORS   Saikia,J.M., Chavez-Martinez,C.L., Kim,N.D., Allibhoy,S., Kim,H.J.,
            Simonyan,L., Smadi,S., Tsai,K.M., Romaus-Sanjurjo,D., Jin,Y. and
            Zheng,B.
  TITLE     A Critical Role for DLK and LZK in Axonal Repair in the Mammalian
            Spinal Cord
  JOURNAL   J Neurosci 42 (18), 3716-3732 (2022)
   PUBMED   35361703
  REMARK    GeneRIF: A Critical Role for DLK and LZK in Axonal Repair in the
            Mammalian Spinal Cord.
REFERENCE   4  (residues 1 to 959)
  AUTHORS   Li,Y., Ritchie,E.M., Steinke,C.L., Qi,C., Chen,L., Zheng,B. and
            Jin,Y.
  TITLE     Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and
            slow degeneration depending on signaling strength
  JOURNAL   Elife 10, e63509 (2021)
   PUBMED   33475086
  REMARK    GeneRIF: Activation of MAP3K DLK and LZK in Purkinje cells causes
            rapid and slow degeneration depending on signaling strength.
            Erratum:[Elife. 2023 Feb 13;12:e86472. doi: 10.7554/eLife.86472.
            PMID: 36779959]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 959)
  AUTHORS   Chen,M., Geoffroy,C.G., Meves,J.M., Narang,A., Li,Y., Nguyen,M.T.,
            Khai,V.S., Kong,X., Steinke,C.L., Carolino,K.I., Elziere,L.,
            Goldberg,M.P., Jin,Y. and Zheng,B.
  TITLE     Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte
            Reactivity in the Adult Mammalian CNS
  JOURNAL   Cell Rep 22 (13), 3587-3597 (2018)
   PUBMED   29590625
  REMARK    GeneRIF: LZK overexpression in astrocytes enhanced astrogliosis and
            reduced lesion size. Remarkably, in the absence of injury, LZK
            overexpression alone induced widespread astrogliosis in the CNS and
            upregulated astrogliosis activators pSTAT3 and SOX9.
REFERENCE   6  (residues 1 to 959)
  AUTHORS   Dickson,H.M., Zurawski,J., Zhang,H., Turner,D.L. and Vojtek,A.B.
  TITLE     POSH is an intracellular signal transducer for the axon outgrowth
            inhibitor Nogo66
  JOURNAL   J Neurosci 30 (40), 13319-13325 (2010)
   PUBMED   20926658
  REMARK    GeneRIF: Scaffold protein POSH, in association with Shroom3 and
            mixed lineage kinase LZK, relays axon outgrowth inhibition
            downstream of NogoA and PirB proteins.
REFERENCE   7  (residues 1 to 959)
  AUTHORS   Saiga,T., Fukuda,T., Matsumoto,M., Tada,H., Okano,H.J., Okano,H.
            and Nakayama,K.I.
  TITLE     Fbxo45 forms a novel ubiquitin ligase complex and is required for
            neuronal development
  JOURNAL   Mol Cell Biol 29 (13), 3529-3543 (2009)
   PUBMED   19398581
REFERENCE   8  (residues 1 to 959)
  AUTHORS   Itoh,A., Horiuchi,M., Bannerman,P., Pleasure,D. and Itoh,T.
  TITLE     Impaired regenerative response of primary sensory neurons in
            ZPK/DLK gene-trap mice
  JOURNAL   Biochem Biophys Res Commun 383 (2), 258-262 (2009)
   PUBMED   19358824
REFERENCE   9  (residues 1 to 959)
  AUTHORS   Craig,E.A., Stevens,M.V., Vaillancourt,R.R. and Camenisch,T.D.
  TITLE     MAP3Ks as central regulators of cell fate during development
  JOURNAL   Dev Dyn 237 (11), 3102-3114 (2008)
   PUBMED   18855897
  REMARK    Review article
REFERENCE   10 (residues 1 to 959)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ480427.1, AK047986.1, AK054039.1, BB455895.2, BB549158.2,
            BP761466.1 and CX240141.1.
            
            On or before May 13, 2006 this sequence version replaced
            XP_484537.2, XP_917498.1, XP_993352.1, NP_766409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ480427.1, SRR9219382.104303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..959
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.92 cM"
     Protein         1..959
                     /product="mitogen-activated protein kinase kinase kinase
                     13"
                     /EC_number="2.7.11.25"
                     /calculated_mol_wt=106856
     Region          1..47
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          173..409
                     /region_name="STKc_MAP3K12_13"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13;
                     cd14059"
                     /db_xref="CDD:270961"
     Site            order(173..177,181,192,194,216,232..235,239,241,278,280,
                     282..283,285,296,299,314..317)
                     /site_type="active"
                     /db_xref="CDD:270961"
     Site            order(173..177,181,192,194,216,232..235,239,278,280,
                     282..283,285,296)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270961"
     Site            order(177,239,241,278,280,282,299,314..317)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270961"
     Site            295..317
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270961"
     Region          432..453
                     /region_name="Leucine-zipper 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          485..506
                     /region_name="Leucine-zipper 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          533..599
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          739..828
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          842..902
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     Region          927..959
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q1HKZ5.1)"
     CDS             1..959
                     /gene="Map3k13"
                     /gene_synonym="C130026N12Rik; LZK"
                     /coded_by="NM_172821.3:1..2880"
                     /db_xref="CCDS:CCDS37294.1"
                     /db_xref="GeneID:71751"
                     /db_xref="MGI:MGI:2444243"
ORIGIN      
        1 manpqehlsc sslphlplte nktsggrnel aamgnhpspk lpedpqerga iqselmeitg
       61 spisttvlts vsedsrgqfe nsvlqlreqd esemtlslgn sntvdgentn gpedikiqfs
      121 rsgsgsggfl eglfgclrpv wniigkayst dyklqqqdtw evpfeeisel qwlgsgaqga
      181 vflgkfraee vaikkvreqn etdikhlrkl khpniiafkg vctqapcyci imeycahgql
      241 yevlragrki tprllvdwst giasgmnylh lhkiihrdlk spnvlvthtd avkisdfgts
      301 kelsdkstkm sfagtvawma pevirnepvs ekvdiwsfgv vlwelltgei pykdvdssai
      361 iwgvgsnslh lpvpstcpdg fkilmkqtwq skprnrpsfr qtlmhldias advlatpqet
      421 yfksqaewre evkkhfekik segtcihrld eelirrrree lrhaldireh yerklerann
      481 lymelsaiml qlemrekell kreqavekky pgtykrhpvr piihpnamek lmkrkgvphk
      541 agvqtkrpdl lrsegipste avptasplsg spkmstassr sryrskprhr rgnsrgshsd
      601 faailktqpa qensphptym hhtqaqcasv hqhnplqqqy qqippaqpqs rhprlnahgq
      661 diatcannlr yfgpaaalrs plsnhaqrqm pgsspdlist amaadwrnse ldqdqvgpwg
      721 ccqaepydpc fqcrpehsgs ldvpttepvg rspdlssspa hnplsgnaqg sertgangfs
      781 gcqsgishqf tppmlpqktr plqksgddss eeegevdsev efprrqrphr cissyqsyst
      841 fssenfsvsd geegntsdhs nspdesanrr qdrlaetldd llsqtpeapi eisshsdgls
      901 dkecavrrvk tqmslgklca eergyenpvq fgdsdcdsse gecsdatvrt sknyssatw
//
LOCUS       NP_062291                239 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor necrosis factor ligand superfamily member 14 [Mus musculus].
ACCESSION   NP_062291
VERSION     NP_062291.1
DBSOURCE    REFSEQ: accession NM_019418.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 239)
  AUTHORS   Long,S.J., Zheng,Q.Y., Xu,F., Li,G.Q., Chen,J., Chen,W.J., Xu,J.M.,
            Gao,X.L., Liang,S.J. and Xu,G.L.
  TITLE     TNFSF14-HVEM/LTbetaR Exacerbates Keratinocyte Abnormalities and
            IMQ-Induced Psoriatic Skin Inflammation via Activating
            NF-kappaB/TWIST1 Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (15), e70774 (2025)
   PUBMED   40768619
REFERENCE   2  (residues 1 to 239)
  AUTHORS   Oranger,A., Colaianni,G., Ingravallo,G., Scarcella,V.S.,
            Faienza,M.F., Grano,M., Colucci,S. and Brunetti,G.
  TITLE     LIGHT/TNFSF14 Affects Adipose Tissue Phenotype
  JOURNAL   Int J Mol Sci 25 (2), 716 (2024)
   PUBMED   38255789
  REMARK    GeneRIF: LIGHT/TNFSF14 Affects Adipose Tissue Phenotype.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 239)
  AUTHORS   Zhang,N., Liu,X., Qin,J., Sun,Y., Xiong,H., Lin,B., Liu,K., Tan,B.,
            Zhang,C., Huang,C., Ren,S., Liu,M. and Du,B.
  TITLE     LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity
            through reversing immunosuppressive tumor microenvironment
  JOURNAL   Mol Ther 31 (9), 2575-2590 (2023)
   PUBMED   37408308
  REMARK    GeneRIF: LIGHT/TNFSF14 promotes CAR-T cell trafficking and
            cytotoxicity through reversing immunosuppressive tumor
            microenvironment.
REFERENCE   4  (residues 1 to 239)
  AUTHORS   Hsu,C.Y., Huang,C.Y., Shih,C.M., Lin,Y.W., Huang,P.H., Lin,S.J.,
            Liu,C.W., Lin,C.Y. and Lin,F.Y.
  TITLE     Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts
            Neovascularization by Decreasing Circulating Endothelial Progenitor
            Cells and Function
  JOURNAL   Int J Mol Sci 24 (8), 6997 (2023)
   PUBMED   37108160
  REMARK    GeneRIF: Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts
            Neovascularization by Decreasing Circulating Endothelial Progenitor
            Cells and Function.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 239)
  AUTHORS   Lai,D., Lv,Z., Lu,X., Shang,P., Geng,Y. and Wang,P.
  TITLE     LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling
            Pathway-Induced Acute Hepatitis
  JOURNAL   Mediators Inflamm 2023, 3732315 (2023)
   PUBMED   36654880
  REMARK    GeneRIF: LIGHT Amplification by NF-kappaB Contributes to TLR3
            Signaling Pathway-Induced Acute Hepatitis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 239)
  AUTHORS   Shaikh,R.B., Santee,S., Granger,S.W., Butrovich,K., Cheung,T.,
            Kronenberg,M., Cheroutre,H. and Ware,C.F.
  TITLE     Constitutive expression of LIGHT on T cells leads to lymphocyte
            activation, inflammation, and tissue destruction
  JOURNAL   J Immunol 167 (11), 6330-6337 (2001)
   PUBMED   11714797
REFERENCE   7  (residues 1 to 239)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   8  (residues 1 to 239)
  AUTHORS   Tamada,K., Shimozaki,K., Chapoval,A.I., Zhu,G., Sica,G., Flies,D.,
            Boone,T., Hsu,H., Fu,Y.X., Nagata,S., Ni,J. and Chen,L.
  TITLE     Modulation of T-cell-mediated immunity in tumor and
            graft-versus-host disease models through the LIGHT co-stimulatory
            pathway
  JOURNAL   Nat Med 6 (3), 283-289 (2000)
   PUBMED   10700230
REFERENCE   9  (residues 1 to 239)
  AUTHORS   Misawa,K., Nosaka,T., Kojima,T., Hirai,M. and Kitamura,T.
  TITLE     Molecular cloning and characterization of a mouse homolog of human
            TNFSF14, a member of the TNF superfamily
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 89-91 (2000)
   PUBMED   10894944
REFERENCE   10 (residues 1 to 239)
  AUTHORS   Matsumoto,M.
  TITLE     Role of TNF ligand and receptor family in the lymphoid
            organogenesis defined by gene targeting
  JOURNAL   J Med Invest 46 (3-4), 141-150 (1999)
   PUBMED   10687308
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025692.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029155.1, BC125479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.71 cM"
     Protein         1..239
                     /product="tumor necrosis factor ligand superfamily member
                     14"
                     /note="tumor necrosis factor ligand 1d"
                     /calculated_mol_wt=26207
     Site            38..58
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYH9.1)"
     Site            81..82
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYH9.1)"
     Site            order(95,140,142,201,206,233,237)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Site            100
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYH9.1)"
     Region          110..239
                     /region_name="TNF"
                     /note="TNF(Tumour Necrosis Factor) family; pfam00229"
                     /db_xref="CDD:425540"
     Site            order(113..114,119,163,170,175)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     Site            191
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYH9.1)"
     CDS             1..239
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /coded_by="NM_019418.4:114..833"
                     /db_xref="CCDS:CCDS28928.1"
                     /db_xref="GeneID:50930"
                     /db_xref="MGI:MGI:1355317"
ORIGIN      
        1 mesvvqpsvf vvdgqtdipf rrleqnhrrr rcgtvqvsla lvlllgagla tqgwfllrlh
       61 qrlgdivahl pdggkgswek liqdqrshqa npaahltgan asligiggpl lwetrlglaf
      121 lrgltyhdga lvtmepgyyy vyskvqlsgv gcpqglangl pithglykrt srypkelell
      181 vsrrspcgra nssrvwwdss flggvvhlea geevvvrvpg nrlvrprdgt rsyfgafmv
//
LOCUS       NP_032680                657 aa            linear   ROD 27-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 15A [Mus musculus].
ACCESSION   NP_032680
VERSION     NP_032680.1
DBSOURCE    REFSEQ: accession NM_008654.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Bouchla,A., Sotiropoulou,C.D., Esteb,C., Loupis,T.,
            Papageorgiou,S.G., Deliconstantinos,G.G., Pagoni,M.,
            Hatzimichael,E., Dellatola,M., Kalomoiri,S., Apostolidou,E.,
            Kontos,C.K., Thomopoulos,T.P., Karantanos,T. and Pappa,V.
  TITLE     Silencing of the DNA damage repair regulator PPP1R15A sensitizes
            acute myeloid leukemia cells to chemotherapy
  JOURNAL   Ann Hematol 103 (8), 2853-2863 (2024)
   PUBMED   38842564
  REMARK    GeneRIF: Silencing of the DNA damage repair regulator PPP1R15A
            sensitizes acute myeloid leukemia cells to chemotherapy.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Schraps,N., Tirre,M., Pyschny,S., Reis,A., Schlierbach,H.,
            Seidl,M., Kehl,H.G., Schanzer,A., Heger,J., Jux,C. and
            Drenckhahn,J.D.
  TITLE     Cardiomyocyte maturation alters molecular stress response
            capacities and determines cell survival upon mitochondrial
            dysfunction
  JOURNAL   Free Radic Biol Med 213, 248-265 (2024)
   PUBMED   38266827
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Oliveira,M.M., Mohamed,M., Elder,M.K., Banegas-Morales,K.,
            Mamcarz,M., Lu,E.H., Golhan,E.A.N., Navrange,N., Chatterjee,S.,
            Abel,T. and Klann,E.
  TITLE     The integrated stress response effector GADD34 is repurposed by
            neurons to promote stimulus-induced translation
  JOURNAL   Cell Rep 43 (2), 113670 (2024)
   PUBMED   38219147
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Lee,Y.Y., Cevallos,R.C. and Jan,E.
  TITLE     An upstream open reading frame regulates translation of GADD34
            during cellular stresses that induce eIF2alpha phosphorylation
  JOURNAL   J Biol Chem 284 (11), 6661-6673 (2009)
   PUBMED   19131336
  REMARK    GeneRIF: GADD34 translation is regulated by a unique 5'UTR uORF
            mechanism to ensure proper GADD34 expression during eIF2alpha
            phosphorylation
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Cheng,G., Gross,M., Brett,M.E. and He,B.
  TITLE     AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein
            of herpes simplex virus type 1 is required for the formation of a
            high-molecular-weight complex that dephosphorylates eIF-2alpha
  JOURNAL   J Virol 75 (8), 3666-3674 (2001)
   PUBMED   11264356
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Weiss,R.S., Enoch,T. and Leder,P.
  TITLE     Inactivation of mouse Hus1 results in genomic instability and
            impaired responses to genotoxic stress
  JOURNAL   Genes Dev 14 (15), 1886-1898 (2000)
   PUBMED   10921903
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Hollander,M.C., Zhan,Q., Bae,I. and Fornace,A.J. Jr.
  TITLE     Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
  JOURNAL   J Biol Chem 272 (21), 13731-13737 (1997)
   PUBMED   9153226
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Sequence of MyD116 cDNA: a novel myeloid differentiation primary
            response gene induced by IL6
  JOURNAL   Nucleic Acids Res 18 (9), 2823 (1990)
   PUBMED   2339071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4, AK079339.1, BC138486.1 and AW493042.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51829.1, BC138486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 19131336
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.34 cM"
     Protein         1..657
                     /product="protein phosphatase 1 regulatory subunit 15A"
                     /note="growth arrest and DNA damage-inducible protein
                     GADD34; myeloid differentiation primary response protein
                     MyD116; myeloid differentiation primary response gene 116;
                     growth arrest and DNA-damage-inducible 34; protein
                     phosphatase 1, regulatory (inhibitor) subunit 15A"
                     /calculated_mol_wt=71709
     Region          1..60
                     /region_name="Required for localization in the endoplasmic
                     reticulum. /evidence=ECO:0000250|UniProtKB:O75807"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          65..89
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          101..123
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          156..278
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Site            239
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O75807; propagated from
                     UniProtKB/Swiss-Prot (P17564.1)"
     Region          283..451
                     /region_name="4.5 X approximate repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          291..496
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          323..503
                     /region_name="Interaction with SMAD7.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O75807; propagated from
                     UniProtKB/Swiss-Prot (P17564.1)"
     Site            406
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O75807; propagated from
                     UniProtKB/Swiss-Prot (P17564.1)"
     Region          443..548
                     /region_name="Interaction with KMT2A/MLL1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Site            505
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O75807; propagated from
                     UniProtKB/Swiss-Prot (P17564.1)"
     Region          529..576
                     /region_name="Interaction with SMARCB1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     Region          <545..612
                     /region_name="PP1c_bdg"
                     /note="Phosphatase-1 catalytic subunit binding region;
                     pfam10488"
                     /db_xref="CDD:431311"
     Region          610..657
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17564.1)"
     CDS             1..657
                     /gene="Ppp1r15a"
                     /gene_synonym="9630030H21; Gadd34; Myd116"
                     /coded_by="NM_008654.2:284..2257"
                     /db_xref="CCDS:CCDS21249.1"
                     /db_xref="GeneID:17872"
                     /db_xref="MGI:MGI:1927072"
ORIGIN      
        1 mapsprpqhv lhwrdahnfy llsplmglls rawsrlrgpe vpeawlaktv tgadqieaaa
       61 lltptpvsgn llphgetees gspeqsqaaq rlclveaess ppetwglsnv deynakpgqd
      121 dlrekemert agkatlqpag lqgadkrlge vvareegvae payptsqleg gpaeneedge
      181 tvktyqasaa siapgykpst pvpflgeaeh qateekgten kadpsnspss gshsraweyy
      241 srekpkqege akveahragq ghpcrnaeae eggpettfvc tgnaflkawv yrpgedteee
      301 dnsdsdsaee dtaqtgatph tsaflkawvy rpgedteeed sdsdsaeedt aqtgatphts
      361 aflkawvyrp gedteeensd ldsaeedtaq tgatphtsaf lkawvyrpge dteeensdld
      421 saeedtaqtg atphtspflk awvyrpgedt eddteeeeds envapgdset adssqspclq
      481 pqrclpgekt kgrgeepplf qvafylpgek pespwaapkl plrlqrrlrl fkaptrdqdp
      541 eiplkarkvh faekvtvhfl avwagpaqaa rrgpweqfar drsrfarria qaeeklgpyl
      601 tpdsrarawa rlrnpslpqs eprssseatp ltqdvttpsp lpsetpspsl ylggrrg
//
LOCUS       NP_001346114             332 aa            linear   ROD 27-AUG-2025
DEFINITION  spermine synthase isoform 2 [Mus musculus].
ACCESSION   NP_001346114 XP_006528838
VERSION     NP_001346114.1
DBSOURCE    REFSEQ: accession NM_001359185.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 332)
  AUTHORS   Yorgan,T.A., Zhu,Y., Wiedemann,P., Schoneck,K., Pohl,S.,
            Schweizer,M., Amling,M., Barvencik,F., Oheim,R. and Schinke,T.
  TITLE     Inactivation of spermine synthase in mice causes osteopenia due to
            reduced osteoblast activity
  JOURNAL   J Bone Miner Res 39 (11), 1606-1620 (2024)
   PUBMED   39331754
REFERENCE   2  (residues 1 to 332)
  AUTHORS   Akinyele,O., Munir,A., Johnson,M.A., Perez,M.S., Gao,Y.,
            Foley,J.R., Nwafor,A., Wu,Y., Murray-Stewart,T., Casero,R.A. Jr.,
            Bayir,H. and Kemaladewi,D.U.
  TITLE     Impaired polyamine metabolism causes behavioral and neuroanatomical
            defects in a mouse model of Snyder-Robinson syndrome
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38463005
REFERENCE   3  (residues 1 to 332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 332)
  AUTHORS   Wang,L., Li,S., Wang,K., Wang,N., Liu,Q., Sun,Z., Wang,L., Wang,L.,
            Liu,Q., Song,C. and Yang,Q.
  TITLE     Spermine enhances antiviral and anticancer responses by stabilizing
            DNA binding with the DNA sensor cGAS
  JOURNAL   Immunity 56 (2), 272-288 (2023)
   PUBMED   36724787
REFERENCE   5  (residues 1 to 332)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 332)
  AUTHORS   Pegg,A.E. and Michael,A.J.
  TITLE     Spermine synthase
  JOURNAL   Cell Mol Life Sci 67 (1), 113-121 (2010)
   PUBMED   19859664
  REMARK    Review article
REFERENCE   7  (residues 1 to 332)
  AUTHORS   Korhonen,V.P., Niiranen,K., Halmekyto,M., Pietila,M., Diegelman,P.,
            Parkkinen,J.J., Eloranta,T., Porter,C.W., Alhonen,L. and Janne,J.
  TITLE     Spermine deficiency resulting from targeted disruption of the
            spermine synthase gene in embryonic stem cells leads to enhanced
            sensitivity to antiproliferative drugs
  JOURNAL   Mol Pharmacol 59 (2), 231-238 (2001)
   PUBMED   11160858
REFERENCE   8  (residues 1 to 332)
  AUTHORS   Meyer,R.A. Jr., Henley,C.M., Meyer,M.H., Morgan,P.L.,
            McDonald,A.G., Mills,C. and Price,D.K.
  TITLE     Partial deletion of both the spermine synthase gene and the Pex
            gene in the X-linked hypophosphatemic, gyro (Gy) mouse
  JOURNAL   Genomics 48 (3), 289-295 (1998)
   PUBMED   9545633
REFERENCE   9  (residues 1 to 332)
  AUTHORS   Lorenz,B., Francis,F., Gempel,K., Boddrich,A., Josten,M.,
            Schmahl,W., Schmidt,J., Lehrach,H., Meitinger,T. and Strom,T.M.
  TITLE     Spermine deficiency in Gy mice caused by deletion of the spermine
            synthase gene
  JOURNAL   Hum Mol Genet 7 (3), 541-547 (1998)
   PUBMED   9467015
REFERENCE   10 (residues 1 to 332)
  AUTHORS   Strom,T.M., Francis,F., Lorenz,B., Boddrich,A., Econs,M.J.,
            Lehrach,H. and Meitinger,T.
  TITLE     Pex gene deletions in Gy and Hyp mice provide mouse models for
            X-linked hypophosphatemia
  JOURNAL   Hum Mol Genet 6 (2), 165-171 (1997)
   PUBMED   9063736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663072.12.
            
            On Dec 23, 2017 this sequence version replaced XP_006528838.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164137
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.48 cM"
     Protein         1..332
                     /product="spermine synthase isoform 2"
                     /EC_number="2.5.1.22"
                     /note="spermidine aminopropyltransferase"
                     /calculated_mol_wt=37597
     Region          1..83
                     /region_name="SpmSyn_N"
                     /note="S-adenosylmethionine decarboxylase N -terminal;
                     pfam17950"
                     /db_xref="CDD:465581"
     Region          89..138
                     /region_name="Spermine_synt_N"
                     /note="Spermidine synthase tetramerization domain;
                     pfam17284"
                     /db_xref="CDD:407397"
     Region          141..331
                     /region_name="Spermine_synth"
                     /note="Spermine/spermidine synthase domain; pfam01564"
                     /db_xref="CDD:396237"
     CDS             1..332
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /coded_by="NM_001359185.1:131..1129"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:20603"
                     /db_xref="MGI:MGI:109490"
ORIGIN      
        1 mtesvhtwqd hgylatytnk ngsfanlriy phglvlldlq sydsdvqgkq etdsllnkie
       61 ekmkelsqds tgrvkrlppi vrggaidryw ptadgrlvey didevvyded spyqnikilh
      121 skqfgnilil sgdvnlaesd laytraimgs gkedytgkdv lilgggdggi lceivklkpk
      181 mvtmveidqm vidgckkymr rtcgdvldnl rgdcyqvlie dcipvlkmya kegrefdyvi
      241 ndltavpist speedstwdf lrlildlsmk vlkqdgkyft qgncvnltea lslyeeqlgr
      301 lycpvefske ivcvpsylel wvfytvwkka kp
//
LOCUS       NP_001193314             503 aa            linear   ROD 27-AUG-2025
DEFINITION  mitochondrial antiviral-signaling protein isoform 1 [Mus musculus].
ACCESSION   NP_001193314
VERSION     NP_001193314.1
DBSOURCE    REFSEQ: accession NM_001206385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Soliman,N., Nedelko,T., Mandracci,G., Enssle,S., Grass,V.,
            Fischer,J.C., Bassermann,F., Poeck,H., Kobold,S., El Khawanky,N.
            and Heidegger,S.
  TITLE     Targeting Intracellular Innate RNA-Sensing Systems Overcomes
            Resistance to CAR T-cell Therapy in Solid Tumors
  JOURNAL   Cancer Res 85 (14), 2679-2693 (2025)
   PUBMED   40305099
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Okazaki,T., Nozaki,K., Morimoto,N., Otobe,Y., Saito,R., Abe,S.,
            Okajima,M., Yoshitane,H., Hatta,T., Iemura,S.I., Natsume,T.,
            Kosako,H., Yamasaki,M., Inoue,S., Kondo,T., Koseki,H. and Gotoh,Y.
  TITLE     Membrane topology inversion of GGCX mediates cytoplasmic
            carboxylation for antiviral defense
  JOURNAL   Science 389 (6755), 84-91 (2025)
   PUBMED   40608933
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Paulenda,T., Echalar,B., Potuckova,L., Vachova,V., Kleverov,D.A.,
            Mehringer,J., Potekhina,E., Jacoby,A., Sen,D., Nelson,C.,
            Stegeman,R., Sukhov,V., Kemper,D., Lichti,C.F., Day,N.J., Zhang,T.,
            Husarcikova,K., Bambouskova,M., Fremont,D.H., Qian,W.J.,
            Djuranovic,S., Pavlovic-Djuranovic,S., Belousov,V.V., Krezel,A.M.
            and Artyomov,M.N.
  TITLE     Itaconate modulates immune responses via inhibition of
            peroxiredoxin 5
  JOURNAL   Nat Metab 7 (6), 1183-1203 (2025)
   PUBMED   40251412
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Kobayashi,M., Kobayashi,N., Deguchi,K., Omori,S. and Ichinohe,T.
  TITLE     SARS-CoV-2 infection primes cross-protective respiratory IgA in a
            MyD88- and MAVS-dependent manner
  JOURNAL   NPJ Vaccines 10 (1), 40 (2025)
   PUBMED   40016252
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Kumar,H., Kawai,T., Kato,H., Sato,S., Takahashi,K., Coban,C.,
            Yamamoto,M., Uematsu,S., Ishii,K.J., Takeuchi,O. and Akira,S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Sun,Q., Sun,L., Liu,H.H., Chen,X., Seth,R.B., Forman,J. and
            Chen,Z.J.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Meylan,E., Curran,J., Hofmann,K., Moradpour,D., Binder,M.,
            Bartenschlager,R. and Tschopp,J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Xu,L.G., Wang,Y.Y., Han,K.J., Li,L.Y., Zhai,Z. and Shu,H.B.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Seth,R.B., Sun,L., Ea,C.K. and Chen,Z.J.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153748.1, AK028421.1 and AL808128.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020006.1, AK028421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..503
                     /product="mitochondrial antiviral-signaling protein
                     isoform 1"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=53268
     Region          3..93
                     /region_name="CARD_IPS1"
                     /note="Caspase activation and recruitment domain (CARD)
                     found in IPS-1; cd08811"
                     /db_xref="CDD:260073"
     Region          10..77
                     /region_name="Required for interaction with NLRX1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          119..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          143..147
                     /region_name="Interaction with TRAF2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          153..158
                     /region_name="Interaction with TRAF6 1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            172
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            186
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            234
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          337..503
                     /region_name="Interaction with DHX33.
                     /evidence=ECO:0000269|PubMed:24037184"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          346..398
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            405..406
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          415..418
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          431..436
                     /region_name="Interaction with TRAF6 2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          446..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            479..496
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     CDS             1..503
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_001206385.1:124..1635"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS16760.1"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 mtfaedktyk yirdnhskfc cvdvleilpy lscltasdqd rlrasyrqig nrdtlwglfn
       61 nlqrrpgwve vfiralqice lpgladqvtr vyqsylppgt slrsleplql pdfpaavsgp
      121 safapghnip dhglretpsc pkpvqdtqpp espvenseql lqtnsgavar msggslipsp
      181 nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr talrtnllsg
      241 vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps prlvpvktms
      301 sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan tippernskq
      361 aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa csvdlaisps
      421 sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc assmpwakwl
      481 gatsallavf lavmlyrsrr laq
//
LOCUS       NP_001300851            1031 aa            linear   ROD 27-AUG-2025
DEFINITION  nitric oxide synthase, inducible isoform b [Mus musculus].
ACCESSION   NP_001300851
VERSION     NP_001300851.1
DBSOURCE    REFSEQ: accession NM_001313922.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1031)
  AUTHORS   Zhao,X., Li,J., Zhang,Y., Hu,L., Wu,D., Wu,J., Lyu,R., Li,P.,
            An,G., Cui,R., Sun,T., Zhu,P., Bai,L., Jiang,C. and Zhong,C.
  TITLE     Elevated nitric oxide during colitis restrains GM-CSF production in
            ILC3 cells via suppressing an AhR-Cyp4f13-NF-kappaB axis
  JOURNAL   Nat Commun 16 (1), 5654 (2025)
   PUBMED   40593752
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1031)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1031)
  AUTHORS   Mohanty,I., Fazelinia,H., Raimo,S., Ding,H., Spruce,L.,
            Symeonidou,M., Tenopoulou,M., Ichinose,F., Yamashita,H.,
            Shimokawa,H., Masato,T., Doulias,P.T. and Ischiropoulos,H.
  TITLE     Proteomic surveys of the mouse heart unveil cardiovascular
            responses to nitric oxide/cGMP signaling deficiencies
  JOURNAL   Commun Biol 8 (1), 817 (2025)
   PUBMED   40425728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1031)
  AUTHORS   Ananth,M.R., Gardus,J.D., Huang,C., Palekar,N., Slifstein,M.,
            Zaborszky,L., Parsey,R.V., Talmage,D.A., DeLorenzo,C. and Role,L.W.
  TITLE     A central role for acetylcholine in entorhinal cortex function and
            dysfunction with age in humans and mice
  JOURNAL   Cell Rep 44 (2), 115249 (2025)
   PUBMED   39891909
REFERENCE   5  (residues 1 to 1031)
  AUTHORS   Ball,A.B., Jones,A.E., Nguyen,K.B., Rios,A., Marx,N., Hsieh,W.Y.,
            Yang,K., Desousa,B.R., Kim,K.K.O., Veliova,M., Del Mundo,Z.M.,
            Shirihai,O.S., Beninca,C., Stiles,L., Bensinger,S.J. and
            Divakaruni,A.S.
  TITLE     Pro-inflammatory macrophage activation does not require inhibition
            of oxidative phosphorylation
  JOURNAL   EMBO Rep 26 (4), 982-1002 (2025)
   PUBMED   39753784
REFERENCE   6  (residues 1 to 1031)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   7  (residues 1 to 1031)
  AUTHORS   Lowenstein,C.J., Glatt,C.S., Bredt,D.S. and Snyder,S.H.
  TITLE     Cloned and expressed macrophage nitric oxide synthase contrasts
            with the brain enzyme
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6711-6715 (1992)
   PUBMED   1379716
REFERENCE   8  (residues 1 to 1031)
  AUTHORS   Xie,Q.W., Cho,H.J., Calaycay,J., Mumford,R.A., Swiderek,K.M.,
            Lee,T.D., Ding,A., Troso,T. and Nathan,C.
  TITLE     Cloning and characterization of inducible nitric oxide synthase
            from mouse macrophages
  JOURNAL   Science 256 (5054), 225-228 (1992)
   PUBMED   1373522
REFERENCE   9  (residues 1 to 1031)
  AUTHORS   Lyons,C.R., Orloff,G.J. and Cunningham,J.M.
  TITLE     Molecular cloning and functional expression of an inducible nitric
            oxide synthase from a murine macrophage cell line
  JOURNAL   J Biol Chem 267 (9), 6370-6374 (1992)
   PUBMED   1372907
REFERENCE   10 (residues 1 to 1031)
  AUTHORS   Liew,F.Y., Li,Y., Moss,D., Parkinson,C., Rogers,M.V. and Moncada,S.
  TITLE     Resistance to Leishmania major infection correlates with the
            induction of nitric oxide synthase in murine macrophages
  JOURNAL   Eur J Immunol 21 (12), 3009-3014 (1991)
   PUBMED   1721024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN693247.1, M87039.1 and
            AL592185.35.
            
            Summary: Nitric oxide is a reactive free radical which acts as a
            biologic mediator in several processes, including neurotransmission
            and antimicrobial and antitumoral activities. This gene encodes a
            nitric oxide synthase that is inducible by a combination of
            lipopolysaccharide and certain cytokines. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) contains an alternate exon in
            place of the first two exons compared to variant 1. This difference
            results in translation initiation at a downstream start codon and
            an isoform (b) that is shorter at the N-terminus compared to
            isoform a. Variants 2 and 3 both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     Protein         1..1031
                     /product="nitric oxide synthase, inducible isoform b"
                     /EC_number="1.14.13.39"
                     /note="nitric oxide synthase, inducible; inducible nitric
                     oxide synthase; NOS type II; inducible NOS; macrophage
                     NOS; inducible NO synthase; peptidyl-cysteine
                     S-nitrosylase NOS2; nitric oxide synthase 2, inducible,
                     macrophage"
                     /calculated_mol_wt=117824
     Region          1..377
                     /region_name="NOS_oxygenase_euk"
                     /note="Nitric oxide synthase (NOS) eukaryotic oxygenase
                     domain. NOS produces nitric oxide (NO) by catalyzing a
                     five-electron heme-based oxidation of a guanidine nitrogen
                     of L-arginine to L-citrulline via two successive
                     monooxygenation reactions producing N...; cd00795"
                     /db_xref="CDD:238410"
     Site            order(81,144,228,250..251,253..254,258,262..263,343..344,
                     372)
                     /site_type="active"
                     /db_xref="CDD:238410"
     Region          422..553
                     /region_name="Flavodoxin_1"
                     /note="pfam00258"
                     /db_xref="CDD:425562"
     Region          617..1013
                     /region_name="FNR_like"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; cl06868"
                     /db_xref="CDD:447143"
     Site            order(653,787..790,805..807,823..826,865)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99778"
     Site            order(787,789..790)
                     /site_type="other"
                     /note="conserved FAD binding motif [chemical binding]"
                     /db_xref="CDD:99778"
     Site            order(823,826,829,835)
                     /site_type="other"
                     /note="phosphate binding motif [ion binding]"
                     /db_xref="CDD:99778"
     Site            order(860,864..867,869)
                     /site_type="other"
                     /note="beta-alpha-beta structure motif"
                     /db_xref="CDD:99778"
     Site            order(865..866,896..898,964..965)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99778"
     CDS             1..1031
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /coded_by="NM_001313922.1:246..3341"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:18126"
                     /db_xref="MGI:MGI:97361"
ORIGIN      
        1 mnpksltrgp rdkptpleel lphaiefinq yygsfkeaki eehlarleav tkeiettgty
       61 qltldelifa tkmawrnapr cigriqwsnl qvfdarncst aqemfqhicr hilyatnngn
      121 irsaitvfpq rsdgkhdfrl wnsqliryag yqmpdgtirg daatleftql cidlgwkpry
      181 grfdvlplvl qadgqdpevf eippdlvlev tmehpkyewf qelglkwyal pavanmllev
      241 gglefpacpf ngwymgteig vrdfcdtqry nileevgrrm glethtlasl wkdravtein
      301 vavlhsfqkq nvtimdhhta sesfmkhmqn eyrarggcpa dwiwlvppvs gsitpvfhqe
      361 mlnyvlspfy yyqiepwkth iwqneklrpr rreirfrvlv kvvffasmlm rkvmasrvra
      421 tvlfatetgk sealardlat lfsyafntkv vcmdqykast leeeqlllvv tstfgngdcp
      481 sngqtlkksl fmlrelnhtf ryavfglgss mypqfcafah didqklshlg asqlaptgeg
      541 delsgqedaf rswavqtfra acetfdvrsk hhiqipkrft snatwepqqy rliqspepld
      601 lnralssiha knvftmrlks qqnlqsekss rttllvqltf egsrgpsylp gehlgifpgn
      661 qtalvqgile rvvdcptphq tvclevldes gsywvkdkrl ppcslsqalt yfldittppt
      721 qlqlhklarf atdetdrqrl ealcqpseyn dwkfsnnptf levleefpsl hvpaafllsq
      781 lpilkpryys isssqdhtps evhltvavvt yrtrdgqgpl hhgvcstwir nlkpqdpvpc
      841 fvrsvsgfql pedpsqpcil igpgtgiapf rsfwqqrlhd sqhkglkggr mslvfgcrhp
      901 eedhlyqeem qemvrkrvlf qvhtgysrlp gkpkvyvqdi lqkqlanevl svlhgeqghl
      961 yicgdvrmar dvattlkklv atklnlseeq vedyffqlks qkryhedifg avfsygakkg
     1021 saleepkatr l
//
LOCUS       NP_001135399              52 aa            linear   ROD 27-AUG-2025
DEFINITION  phospholamban [Mus musculus].
ACCESSION   NP_001135399
VERSION     NP_001135399.1
DBSOURCE    REFSEQ: accession NM_001141927.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 52)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 52)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 52)
  AUTHORS   Klocke,B., Britzolaki,A., Saurine,J., Ott,H., Krone,K.,
            Bahamonde,K., Thelen,C., Tzimas,C., Sanoudou,D., Kranias,E.G. and
            Pitychoutis,P.M.
  TITLE     A novel role for phospholamban in the thalamic reticular nucleus
  JOURNAL   Sci Rep 14 (1), 6376 (2024)
   PUBMED   38493225
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 52)
  AUTHORS   Stege,N.M., Oliveira Nunes Teixeira,V., Zijlstra,S.N.,
            Feringa,A.M., de Boer,R.A. and Sillje,H.H.W.
  TITLE     Deletion of DWORF does not affect cardiac function in aging and in
            PLN-R14del cardiomyopathy
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (3), H870-H876 (2024)
   PUBMED   38334971
REFERENCE   5  (residues 1 to 52)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   6  (residues 1 to 52)
  AUTHORS   Kadambi,V.J., Ponniah,S., Harrer,J.M., Hoit,B.D., Dorn,G.W. 2nd,
            Walsh,R.A. and Kranias,E.G.
  TITLE     Cardiac-specific overexpression of phospholamban alters calcium
            kinetics and resultant cardiomyocyte mechanics in transgenic mice
  JOURNAL   J Clin Invest 97 (2), 533-539 (1996)
   PUBMED   8567978
REFERENCE   7  (residues 1 to 52)
  AUTHORS   Hoit,B.D., Khoury,S.F., Kranias,E.G., Ball,N. and Walsh,R.A.
  TITLE     In vivo echocardiographic detection of enhanced left ventricular
            function in gene-targeted mice with phospholamban deficiency
  JOURNAL   Circ Res 77 (3), 632-637 (1995)
   PUBMED   7641333
REFERENCE   8  (residues 1 to 52)
  AUTHORS   Koss,K.L., Ponniah,S., Jones,W.K., Grupp,I.L. and Kranias,E.G.
  TITLE     Differential phospholamban gene expression in murine cardiac
            compartments. Molecular and physiological analyses
  JOURNAL   Circ Res 77 (2), 342-353 (1995)
   PUBMED   7542181
  REMARK    Erratum:[Circ Res 1995 Nov;77(5):1036]
REFERENCE   9  (residues 1 to 52)
  AUTHORS   Luo,W., Grupp,I.L., Harrer,J., Ponniah,S., Grupp,G., Duffy,J.J.,
            Doetschman,T. and Kranias,E.G.
  TITLE     Targeted ablation of the phospholamban gene is associated with
            markedly enhanced myocardial contractility and loss of beta-agonist
            stimulation
  JOURNAL   Circ Res 75 (3), 401-409 (1994)
   PUBMED   8062415
REFERENCE   10 (residues 1 to 52)
  AUTHORS   Ganim,J.R., Luo,W., Ponniah,S., Grupp,I., Kim,H.W., Ferguson,D.G.,
            Kadambi,V., Neumann,J.C., Doetschman,T. and Kranias,E.G.
  TITLE     Mouse phospholamban gene expression during development in vivo and
            in vitro
  JOURNAL   Circ Res 71 (5), 1021-1030 (1992)
   PUBMED   1394867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB658675.1, CA459471.1, AK002622.1 and BM123812.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA787129.1, CA459471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..52
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 27.11 cM"
     Protein         1..52
                     /product="phospholamban"
                     /note="cardiac phospholamban"
                     /calculated_mol_wt=5963
     Region          1..52
                     /region_name="P_lamban"
                     /note="phospholamban; TIGR01294"
                     /db_xref="CDD:273541"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:A4IFH6; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:20890288,
                     ECO:0000269|PubMed:22971924, ECO:0000269|PubMed:26644582,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CaMK2.
                     /evidence=ECO:0000250|UniProtKB:P61012; propagated from
                     UniProtKB/Swiss-Prot (P61014.1)"
     Site            32..52
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P61014.1)"
     CDS             1..52
                     /gene="Pln"
                     /gene_synonym="Plb"
                     /coded_by="NM_001141927.1:345..503"
                     /db_xref="CCDS:CCDS35899.1"
                     /db_xref="GeneID:18821"
                     /db_xref="MGI:MGI:97622"
ORIGIN      
        1 mekvqyltrs airrastiem pqqarqnlqn lfinfclili cllliciivm ll
//
LOCUS       NP_001405938             255 aa            linear   ROD 27-AUG-2025
DEFINITION  low affinity immunoglobulin gamma Fc region receptor II-b isoform 6
            [Mus musculus].
ACCESSION   NP_001405938
VERSION     NP_001405938.1
DBSOURCE    REFSEQ: accession NM_001419009.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 255)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 255)
  AUTHORS   Bennion,K.B., Miranda R Bazzano,J., Liu,D., Wagener,M., Paulos,C.M.
            and Ford,M.L.
  TITLE     Macrophage-derived Fgl2 dampens antitumor immunity through
            regulation of FcgammaRIIB+CD8+ T cells in melanoma
  JOURNAL   JCI Insight 10 (6), e182563 (2025)
   PUBMED   40125553
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 255)
  AUTHORS   Santana,S., Papillion,A., Foote,J.B., Bachus,H., Leon,B., De
            Miguel,C. and Ballesteros-Tato,A.
  TITLE     Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents
            Autoantibody Responses in Systemic Lupus Erythematosus via
            Regulatory T Cell-independent Depletion of T Follicular Helper
            Cells
  JOURNAL   J Immunol 213 (8), 1053-1060 (2024)
   PUBMED   39195194
REFERENCE   4  (residues 1 to 255)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 255)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 255)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (residues 1 to 255)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (residues 1 to 255)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (residues 1 to 255)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (residues 1 to 255)
  AUTHORS   Dickles,H.B., Ahmed,A. and Sachs,D.H.
  TITLE     B-lymphocyte Fc receptor-associated non-H-2 antigens are determined
            by a single polymorphic locus which is linked to the Mls locus
  JOURNAL   J Exp Med 146 (6), 1678-1692 (1977)
   PUBMED   303687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115959.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.591005.1,
                                           SRR13422589.368227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..255
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.02 cM"
     Protein         1..255
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b isoform 6"
                     /note="low affinity immunoglobulin gamma Fc region
                     receptor II; fc-gamma RII; fc-gamma-RIIB; fc gamma
                     receptor IIB; lymphocyte antigen 17; igG Fc receptor II
                     beta; Fc-gamma-RII; Fc gamma RIIB; FcgammaRIIB; low
                     affinity immunoglobulin gamma Fc region receptor II-b"
                     /calculated_mol_wt=28170
     Region          43..125
                     /region_name="Ig2_FcgammaR_like"
                     /note="Second immunoglobulin (Ig)-like domain of
                     Fcgamma-receptors (FcgammaRs), and similar domains;
                     cd05753"
                     /db_xref="CDD:409411"
     Site            order(43,66,72..73)
                     /site_type="other"
                     /note="Fc binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          43..47
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409411"
     Region          52..54
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409411"
     Site            order(56..58,67,72,111)
                     /site_type="other"
                     /note="pentraxin binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          58..65
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409411"
     Region          72..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409411"
     Region          81..86
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409411"
     Region          90..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409411"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409411"
     Region          115..125
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409411"
     CDS             1..255
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /coded_by="NM_001419009.1:81..848"
                     /note="isoform 6 is encoded by transcript variant 7"
                     /db_xref="GeneID:14130"
                     /db_xref="MGI:MGI:95499"
ORIGIN      
        1 mgilpfllip mesnwtvhvf srtlchmllw tavlnlaagt hdwlllqtpq lvflegetit
       61 lrchswrnkl lnrisffhne ksvryhhyss nfsipkanhs hsgdyyckgs lgrtlhqskp
      121 vtitvqgpks srslpvltiv aavtgiavaa iviilvslvy lkkkqvpalp gnpdhremge
      181 tlpeevgeyr qpsggsvpvs pgppsglept ssspynppdl eeaakteaen titysllkhp
      241 ealdeetehd yqnhi
//
LOCUS       NP_001389667            2748 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 8 [Mus musculus].
ACCESSION   NP_001389667
VERSION     NP_001389667.1
DBSOURCE    REFSEQ: accession NM_001402738.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2748)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2748)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2748)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2748)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2748)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2748)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2748)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2748)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2748)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2748)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.612984.1,
                                           SRR17784643.47547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2748
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2748
                     /product="adenomatous polyposis coli protein isoform 8"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=300490
     Region          66..146
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          244..296
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          297..370
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          363..414
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          369..412
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(403,407,411,446,450,454,490,494,498)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          416..457
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          420..457
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          464..499
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          507..548
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          553..593
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          557..591
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          595..635
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          599..635
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          636..923
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          940..1039
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1161..>1178
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1187..1273
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1541..1564
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1566..1619
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1620..1641
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1650..1743
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1777..1851
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          1938..1957
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2129..2474
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2576..2748
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2748
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402738.1:84..8330"
                     /note="isoform 8 is encoded by transcript variant 15"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 mtsgqidlle rlkefnldsn fpgvklrskm slrsygsreg svssrsgecs pvpmgsfprr
       61 tfvngsrest gyleeleker sllladldke ekekdwyyaq lqnltkrids lpltenfslq
      121 tdmtrrqley earqiraame eqlgtcqdme kraqrriari qqiekdilrv rqllqsqaae
      181 aespatrvdh etasvlsssg thsaprrlts hlgtkvemvy sllsmlgthd kddmsrtlla
      241 msssqdscis mrqsgclpll iqllhgndkd svllgnsrgs keararasaa lhniihsqpd
      301 dkrgrreirv lhlleqiray cetcwewqea heqgmdqdkn pmpapvehqi cpavcvlmkl
      361 sfdeehrham nelgglqaia ellqvdcemy gltndhysvt lrryagmalt nltfgdvank
      421 atlcsmkgcm ralvaqlkse sedlqqvias vlrnlswrad vnskktlrev gsvkalmeca
      481 levkkestlk svlsalwnls ahctenkadi cavdgalafl vgtltyrsqt ntlaiiesgg
      541 gilrnvssli atnedhrqil rennclqtll qhlkshslti vsnacgtlwn lsarnpkdqe
      601 alwdmgavsm lknlihskhk miamgsaaal rnlmanrpak ykdanimspg sslpslhvrk
      661 qkaleaelda qhlsetfdni dnlspkashr skqrhkqnly gdyafdanrh ddsrsdnfnt
      721 gnmtvlspyl nttvlpssss srgsldssrs ekdrslerer giglsayhpt tenagtsskr
      781 glqitttaaq iakvmeevsa ihtsqddrss asttefhcva ddrsaarrss ashthsntyn
      841 ftksensnrt csmpyakvey krssndslns vtssdgygkr gqmkpsvesy seddeskfcs
      901 ygqypadlah kihsanhmdd ndgeldtpin yslkysdeql nsgrqspsqn erwarpkhvi
      961 edeikqneqr qarsqntsyp vysentddkh lkfqphfgqq ecvspyrsrg tsgsetnrmg
     1021 sshainqnvn qslcqeddye ddkptnyser yseeeqheee eerptnysik yneekhhvdq
     1081 pidyslkyat disssqkpsf sfsknssaqs tkpehlspss entavppsna krqnqlrpss
     1141 aqrngqtqkg ttckvpsinq etiqtycved tpicfsrcss lsslssadde igcdqttqea
     1201 dsantlqtae vkendvtrsa edpatevpav sqnarakpsr lqasglsses trhnkavefs
     1261 sgakspsksg aqtpksppeh yvqetplvfs rctsvsslds fesrsiassv qsepcsgmvs
     1321 giispsdlpd spgqtmppsr sktpppppqt vqakrevpks kvpaaekres gpkqtavnaa
     1381 vqrvqvlpdv dtllhfates tpdgfscsss lsalsldepf iqkdvelrim ppvqendngn
     1441 eteseqpees nenqdkevek pdsekdlldd sddddieile eciisamptk ssrkakklaq
     1501 tasklpppva rkpsqlpvyk llpaqnrlqa qkhvsftpgd dvprvycveg tpinfstats
     1561 lsdltiespp nelatgdgvr agiqsgefek rdtiptegrs tddaqrgkis sivtpdlddn
     1621 kaeegdilae cinsampkgk shkpfrvkki mdqvqqasst ssganknqvd tkkkkptspv
     1681 kpmpqnteyr trvrkntdsk vnvnteetfs dnkdskkpsl qtnakafnek lpnnedrvrg
     1741 sfaldsphhy tpiegtpycf srndslssld fddddvdlsr ekaelrkgke skdseakvtc
     1801 rpepnssqqa asksqasikh panraqskpv lqkqptfpqs skdgpdrgaa tdeklqnfai
     1861 entpvcfsrn sslsslsdid qennnnkese pikeaepans qgepskpqas gyapksfhve
     1921 dtpvcfsrns slsslsidse ddllqeciss ampkkkrpsr lksesekqsp rkvggilaed
     1981 ltldlkdlqr pdsehafspd senfdwkaiq egansivssl hqaaaaaacl srqassdsds
     2041 ilslksgisl gspfhltpdq eekpftsnkg prilkpgeks tleakkiese nkgikggkkv
     2101 ykslitgkir snseissqmk qplptnmpsi srgrtmihip glrnssssts pvskkgpplk
     2161 tpaskspseg pgattsprgt kpagkselsp itrqtsqisg snkgssrsgs rdstpsrptq
     2221 qplsrpmqsp grnsispgrn gisppnklsq lprtsspsta stkssgsgkm sytspgrqls
     2281 qqnltkqasl sknassiprs esaskglnqm sngngsnkkv elsrmsstks sgsesdrser
     2341 palvrqstfi keapsptlrr kleesasfes lspssrpdsp trsqaqtpvl spslpdmsls
     2401 thpsvqaggw rklppnlspt ieyndgrptk rhdiarshse spsrlpinra gtwkrehskh
     2461 ssslprvstw rrtgssssil sassesseka ksederhvss mpaprqmken qvptkgtwrk
     2521 ikesdisptg masqsassga asgaeskpli yqmappvskt edvwvriedc pinnprsgrs
     2581 ptgntppvid svsekgsssi kdskdthgkq svgsgspvqt vgletrlnsf vqveapeqkg
     2641 teakpgqsnp vsiaetaetc iaertpfsss ssskhsspsg tvaarvtpfn ynpsprkssa
     2701 dstsarpsqi ptpvstntkk rdsktdstes sgaqspkrhs gsylvtsv
//
LOCUS       NP_001185754             733 aa            linear   ROD 27-AUG-2025
DEFINITION  amyloid-beta precursor protein isoform 5 precursor [Mus musculus].
ACCESSION   NP_001185754
VERSION     NP_001185754.1
DBSOURCE    REFSEQ: accession NM_001198825.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 733)
  AUTHORS   Papanikolaou,A., Graykowski,D., Lee,B.I., Yang,M., Ellingford,R.,
            Zunkler,J., Bond,S.A., Rowland,J.M., Rajani,R.M., Harris,S.S.,
            Sharp,D.J. and Busche,M.A.
  TITLE     Selectively vulnerable deep cortical layer 5/6 fast-spiking
            interneurons in Alzheimer's disease models in vivo
  JOURNAL   Neuron 113 (14), 2265-2279 (2025)
   PUBMED   40345184
REFERENCE   2  (residues 1 to 733)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 733)
  AUTHORS   Harris,S.S., Rajani,R.M., Zunkler,J., Ellingford,R., Yang,M.,
            Rowland,J.M., Schmidt,A., Lee,B.I., Kehring,M., Hellmuth,M.,
            Lam,F.K.W., Fassler,D., Erdinger,S., Wolfer,D.P., Sala Frigerio,C.,
            Wolf,F., Hyman,B.T., Muller,U.C. and Busche,M.A.
  TITLE     The amyloid precursor family of proteins in excitatory neurons are
            essential for regulating cortico-hippocampal circuit dynamics in
            vivo
  JOURNAL   Cell Rep 44 (6), 115801 (2025)
   PUBMED   40512617
REFERENCE   4  (residues 1 to 733)
  AUTHORS   Yamauchi,K., Koike,M. and Hioki,H.
  TITLE     A three dimensional immunolabeling method with peroxidase-fused
            nanobodies and fluorochromized tyramide-glucose oxidase signal
            amplification
  JOURNAL   Commun Biol 8 (1), 903 (2025)
   PUBMED   40533487
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 733)
  AUTHORS   Brustovetsky,T., Khanna,R. and Brustovetsky,N.
  TITLE     Collapsin Response Mediator Protein 2 (CRMP2) Modulates
            Mitochondrial Oxidative Metabolism in Knock-In AD Mouse Model
  JOURNAL   Cells 14 (9), 647 (2025)
   PUBMED   40358171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 733)
  AUTHORS   Violette,S.M., Shashikant,C.S., Salbaum,J.M., Belting,H.G.,
            Wang,J.C. and Ruddle,F.H.
  TITLE     Repression of the beta-amyloid gene in a Hox-3.1-producing cell
            line
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3805-3809 (1992)
   PUBMED   1349171
REFERENCE   7  (residues 1 to 733)
  AUTHORS   Fukuchi,K., Deeb,S.S., Kamino,K., Ogburn,C.E., Snow,A.D.,
            Sekiguchi,R.T., Wight,T.N., Piussan,H. and Martin,G.M.
  TITLE     Increased expression of beta-amyloid protein precursor and
            microtubule-associated protein tau during the differentiation of
            murine embryonal carcinoma cells
  JOURNAL   J Neurochem 58 (5), 1863-1873 (1992)
   PUBMED   1560239
REFERENCE   8  (residues 1 to 733)
  AUTHORS   Izumi,R., Yamada,T., Yoshikai,S., Sasaki,H., Hattori,M. and
            Sakaki,Y.
  TITLE     Positive and negative regulatory elements for the expression of the
            Alzheimer's disease amyloid precursor-encoding gene in mouse
  JOURNAL   Gene 112 (2), 189-195 (1992)
   PUBMED   1555768
REFERENCE   9  (residues 1 to 733)
  AUTHORS   Goate,A., Chartier-Harlin,M.C., Mullan,M., Brown,J., Crawford,F.,
            Fidani,L., Giuffra,L., Haynes,A., Irving,N., James,L. et al.
  TITLE     Segregation of a missense mutation in the amyloid precursor protein
            gene with familial Alzheimer's disease
  JOURNAL   Nature 349 (6311), 704-706 (1991)
   PUBMED   1671712
REFERENCE   10 (residues 1 to 733)
  AUTHORS   McAdam,K.P., Anders,R.F., Aiken,G. and Takitaki,F.F.
  TITLE     Secondary amyloidosis and the serum amyloid precursor in leprosy:
            geographical variation and association with leukocytosis
  JOURNAL   Int J Lepr Other Mycobact Dis 45 (2), 150-157 (1977)
   PUBMED   561759
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK128971.1, AK133639.1, BC070409.1 and BP753972.1.
            
            Transcript Variant: Transcript Variant: This variant (5) lacks an
            alternate in-frame exon compared to variant 1. The resulting
            isoform (5) has the same N- and C-termini but is shorter compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128971.1, SRR11927934.6247827.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 46.92 cM"
     Protein         1..733
                     /product="amyloid-beta precursor protein isoform 5
                     precursor"
                     /note="appican; amyloid beta A4 protein; amyloidogenic
                     glycoprotein; alzheimer disease amyloid A4 protein
                     homolog; protease nexin II; amyloid precursor protein;
                     beta-amyloid precursor protein; alzheimer disease amyloid
                     protein; amyloid beta (A4) precursor protein"
                     /calculated_mol_wt=80965
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1839
     mat_peptide     18..733
                     /product="amyloid-beta precursor protein isoform 5"
                     /calculated_mol_wt=80965
     Region          24..188
                     /region_name="A4_EXTRA"
                     /note="amyloid A4; smart00006"
                     /db_xref="CDD:128326"
     Region          294..341
                     /region_name="Kunitz_ABPP-like"
                     /note="Kunitz domain found in the amyloid-beta precursor
                     protein (ABPP) subfamily; cd22607"
                     /db_xref="CDD:438650"
     Site            order(297..305,320,322,324)
                     /site_type="other"
                     /note="serine protease binding site [polypeptide binding]"
                     /db_xref="CDD:438650"
     Region          347..529
                     /region_name="APP_E2"
                     /note="E2 domain of amyloid precursor protein; pfam12925"
                     /db_xref="CDD:463752"
     Region          656..730
                     /region_name="JMTM_Notch_APP"
                     /note="juxtamembrane and transmembrane (JMTM) domain found
                     in Notch and APP family proteins; cl41775"
                     /db_xref="CDD:425406"
     Site            order(669..670,672..673,675..681,683..688)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:411983"
     CDS             1..733
                     /gene="App"
                     /gene_synonym="Abeta; Abpp; Adap; Ag; betaApp; Cvap;
                     E030013M08Rik"
                     /coded_by="NM_001198825.1:150..2351"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5"
                     /db_xref="CCDS:CCDS88955.1"
                     /db_xref="GeneID:11820"
                     /db_xref="MGI:MGI:88059"
ORIGIN      
        1 mlpslallll aawtvralev ptdgnaglla epqiamfcgk lnmhmnvqng kwesdpsgtk
       61 tcigtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthth ivipyrclvg
      121 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr
      181 gvefvccpla eesdsvdsad aeeddsdvww ggadtdyadg gedkvvevae eeevadveee
      241 eadddedved gdeveeeaee pyeeatertt stattttttt esveevvrev cseqaetgpc
      301 ramisrwyfd vtegkcvpff yggcggnrnn fdteeycmav cgsvfpttaa stpdavdkyl
      361 etpgdeneha hfqkakerle akhrermsqv mreweeaerq aknlpkadkk aviqhfqekv
      421 esleqeaane rqqlvethma rveamlndrr rlalenyita lqavpprphh vfnmlkkyvr
      481 aeqkdrqhtl khfehvrmvd pkkaaqirsq vmthlrviye rmnqslslly nvpavaeeiq
      541 devdellqke qnysddvlan miseprisyg ndalmpslte tkttvellpv ngefslddlq
      601 pwhpfgvdsv pantenegsg ltnikteeis evkmdaefgh dsgfevrhqk lvffaedvgs
      661 nkgaiiglmv ggvviatviv itlvmlkkkq ytsihhgvve vdaavtpeer hlskmqqngy
      721 enptykffeq mqn
//
LOCUS       NP_001272845             333 aa            linear   ROD 27-AUG-2025
DEFINITION  geminin coiled-coil domain-containing protein 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001272845
VERSION     NP_001272845.1
DBSOURCE    REFSEQ: accession NM_001285916.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Elorriaga,V., Bouloudi,B., Delberghe,E., Saillour,Y., Morel,J.S.,
            Azzam,P., Moreau,M.X., Stottmann,R., Bahi-Buisson,N., Pierani,A.,
            Spassky,N. and Causeret,F.
  TITLE     Differential contribution of P73+ Cajal-Retzius cells and Reelin to
            cortical morphogenesis
  JOURNAL   Development 152 (9) (2025)
   PUBMED   40207459
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Kaplani,K., Lalioti,M.E., Vassalou,S., Lokka,G., Parlapani,E.,
            Kritikos,G., Lygerou,Z. and Taraviras,S.
  TITLE     Ependymal cell lineage reprogramming as a potential therapeutic
            intervention for hydrocephalus
  JOURNAL   EMBO Mol Med 16 (11), 2725-2748 (2024)
   PUBMED   39468302
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Terre,B., Piergiovanni,G., Segura-Bayona,S., Gil-Gomez,G.,
            Youssef,S.A., Attolini,C.S., Wilsch-Brauninger,M., Jung,C.,
            Rojas,A.M., Marjanovic,M., Knobel,P.A., Palenzuela,L.,
            Lopez-Rovira,T., Forrow,S., Huttner,W.B., Valverde,M.A., de
            Bruin,A., Costanzo,V. and Stracker,T.H.
  TITLE     GEMC1 is a critical regulator of multiciliated cell differentiation
  JOURNAL   EMBO J 35 (9), 942-960 (2016)
   PUBMED   26933123
  REMARK    GeneRIF: The authors found that GEMC1-deficient mice are growth
            impaired, develop hydrocephaly with a high penetrance, and are
            infertile, due to defects in the formation of multiciliated cells
            in the brain, respiratory tract, and germline.
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Arbi,M., Pefani,D.E., Kyrousi,C., Lalioti,M.E., Kalogeropoulou,A.,
            Papanastasiou,A.D., Taraviras,S. and Lygerou,Z.
  TITLE     GemC1 controls multiciliogenesis in the airway epithelium
  JOURNAL   EMBO Rep 17 (3), 400-413 (2016)
   PUBMED   26882546
  REMARK    GeneRIF: GemC1 directly transactivates the promoters of MCIDAS and
            FOXJ1.
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Kyrousi,C., Arbi,M., Pilz,G.A., Pefani,D.E., Lalioti,M.E.,
            Ninkovic,J., Gotz,M., Lygerou,Z. and Taraviras,S.
  TITLE     Mcidas and GemC1 are key regulators for the generation of
            multiciliated ependymal cells in the adult neurogenic niche
  JOURNAL   Development 142 (21), 3661-3674 (2015)
   PUBMED   26395491
  REMARK    GeneRIF: Results suggest that Mcidas and GemC1 are key players in
            the generation of multiciliated ependymal cells of the adult
            neurogenic niche.
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Wu,J., Bao,J., Kim,M., Yuan,S., Tang,C., Zheng,H., Mastick,G.S.,
            Xu,C. and Yan,W.
  TITLE     Two miRNA clusters, miR-34b/c and miR-449, are essential for normal
            brain development, motile ciliogenesis, and spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 111 (28), E2851-E2857 (2014)
   PUBMED   24982181
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Balestrini,A., Cosentino,C., Errico,A., Garner,E. and Costanzo,V.
  TITLE     GEMC1 is a TopBP1-interacting protein required for chromosomal DNA
            replication
  JOURNAL   Nat Cell Biol 12 (5), 484-491 (2010)
   PUBMED   20383140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141059.1, AC154565.2 and BC086669.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and contains an alternate 5'
            terminal exon compared to variant 1. The encoded protein (isoform
            2) has a distinct N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141059.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.56 cM"
     Protein         1..333
                     /product="geminin coiled-coil domain-containing protein 1
                     isoform 2"
                     /note="geminin coiled-coil domain-containing protein 1"
                     /calculated_mol_wt=37627
     Region          28..>180
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          73..133
                     /region_name="GemC1_CC"
                     /note="central coiled-coil domain of geminin coiled-coil
                     domain-containing protein 1; cd22588"
                     /db_xref="CDD:439142"
     Site            order(73,76..77,79..80,83..84,86..87,90..91,93..94,97..98,
                     100..101,104,108,111,114)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:439142"
     Region          145..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3URY2.1)"
     CDS             1..333
                     /gene="Gmnc"
                     /gene_synonym="Gemc1; Gm1778; Gm606"
                     /coded_by="NM_001285916.1:403..1404"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS88906.1"
                     /db_xref="GeneID:239789"
                     /db_xref="MGI:MGI:2685452"
ORIGIN      
        1 mnsilpcqdq yfvggqsync pystttsesg vdvsketwvs fwaaglldnt elqqapqvle
       61 spselsfpvl dscsweeaql ssqlyrnkql qdtllqkeee larlheennh lrqylnstlv
      121 krleekakkl lssdefskvf gklrkekrkp kehrhspaei pqfktakrnl stefsnceeq
      181 pgphvdpwvl qtlglkdlnt iddtlpanys attshpravp sisslfvhda ngyanvprdl
      241 hldyvgqgth gshttsihqe dchsfprlsn ppvrvqtlpy htadvspnkt emafstslsp
      301 hcnvkthsfh qgqafvrrde eggwkftwvp kqt
//
LOCUS       NP_001389661            2825 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 4 [Mus musculus].
ACCESSION   NP_001389661 XP_036016837
VERSION     NP_001389661.1
DBSOURCE    REFSEQ: accession NM_001402732.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2825)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2825)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2825)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2825)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2825)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2825)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2825)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2825)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2825)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2825)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Mar 21, 2022 this sequence version replaced XP_036016837.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1217984.1,
                                           SRR14777534.1351929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2825
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2825
                     /product="adenomatous polyposis coli protein isoform 4"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=309008
     Region          4..55
                     /region_name="APC_N_CC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     pfam16689"
                     /db_xref="CDD:435517"
     Region          125..205
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          303..355
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          356..429
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          453..489
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          493..534
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          497..534
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          544..576
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(567,571,575,614,618,622,659,663,667)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          584..625
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          630..670
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          634..668
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          672..712
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          676..712
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          713..1000
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          1017..1116
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1238..>1255
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1264..1350
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1618..1641
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1643..1696
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1697..1718
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1727..1820
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1854..1928
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          2015..2034
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2206..2551
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2653..2825
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2825
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402732.1:396..8873"
                     /note="isoform 4 is encoded by transcript variant 9"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 maaasydqll kqvealkmen snlrqeledn snhltklete asnmkevlkq lqgsiedetm
       61 tsgqidller lkefnldsnf pgvklrskms lrsygsregs vssrsgecsp vpmgsfprrt
      121 fvngsrestg yleelekers llladldkee kekdwyyaql qnltkridsl pltenfslqt
      181 dmtrrqleye arqiraamee qlgtcqdmek raqrriariq qiekdilrvr qllqsqaaea
      241 espatrvdhe tasvlsssgt hsaprrltsh lgtkvemvys llsmlgthdk ddmsrtllam
      301 sssqdscism rqsgclplli qllhgndkds vllgnsrgsk eararasaal hniihsqpdd
      361 krgrreirvl hlleqirayc etcwewqeah eqgmdqdknp mpapvehqic pavcvlmkls
      421 fdeehrhamn elgrkatrgi ssqelgqgls gglqaiaell qvdcemyglt ndhysvtlrr
      481 yagmaltnlt fgdvankatl csmkgcmral vaqlksesed lqqviasvlr nlswradvns
      541 kktlrevgsv kalmecalev kkestlksvl salwnlsahc tenkadicav dgalaflvgt
      601 ltyrsqtntl aiiesgggil rnvssliatn edhrqilren nclqtllqhl kshsltivsn
      661 acgtlwnlsa rnpkdqealw dmgavsmlkn lihskhkmia mgsaaalrnl manrpakykd
      721 animspgssl pslhvrkqka leaeldaqhl setfdnidnl spkashrskq rhkqnlygdy
      781 afdanrhdds rsdnfntgnm tvlspylntt vlpsssssrg sldssrsekd rslerergig
      841 lsayhptten agtsskrglq itttaaqiak vmeevsaiht sqddrssast tefhcvaddr
      901 saarrssash thsntynftk sensnrtcsm pyakveykrs sndslnsvts sdgygkrgqm
      961 kpsvesysed deskfcsygq ypadlahkih sanhmddndg eldtpinysl kysdeqlnsg
     1021 rqspsqnerw arpkhviede ikqneqrqar sqntsypvys entddkhlkf qphfgqqecv
     1081 spyrsrgtsg setnrmgssh ainqnvnqsl cqeddyeddk ptnyseryse eeqheeeeer
     1141 ptnysikyne ekhhvdqpid yslkyatdis ssqkpsfsfs knssaqstkp ehlspssent
     1201 avppsnakrq nqlrpssaqr ngqtqkgttc kvpsinqeti qtycvedtpi cfsrcsslss
     1261 lssaddeigc dqttqeadsa ntlqtaevke ndvtrsaedp atevpavsqn arakpsrlqa
     1321 sglssestrh nkavefssga kspsksgaqt pksppehyvq etplvfsrct svssldsfes
     1381 rsiassvqse pcsgmvsgii spsdlpdspg qtmppsrskt pppppqtvqa krevpkskvp
     1441 aaekresgpk qtavnaavqr vqvlpdvdtl lhfatestpd gfscssslsa lsldepfiqk
     1501 dvelrimppv qendngnete seqpeesnen qdkevekpds ekdllddsdd ddieileeci
     1561 isamptkssr kakklaqtas klpppvarkp sqlpvykllp aqnrlqaqkh vsftpgddvp
     1621 rvycvegtpi nfstatslsd ltiesppnel atgdgvragi qsgefekrdt iptegrstdd
     1681 aqrgkissiv tpdlddnkae egdilaecin sampkgkshk pfrvkkimdq vqqasstssg
     1741 anknqvdtkk kkptspvkpm pqnteyrtrv rkntdskvnv nteetfsdnk dskkpslqtn
     1801 akafneklpn nedrvrgsfa ldsphhytpi egtpycfsrn dslssldfdd ddvdlsreka
     1861 elrkgkeskd seakvtcrpe pnssqqaask sqasikhpan raqskpvlqk qptfpqsskd
     1921 gpdrgaatde klqnfaient pvcfsrnssl sslsdidqen nnnkesepik eaepansqge
     1981 pskpqasgya pksfhvedtp vcfsrnssls slsidseddl lqecissamp kkkrpsrlks
     2041 esekqsprkv ggilaedltl dlkdlqrpds ehafspdsen fdwkaiqega nsivsslhqa
     2101 aaaaaclsrq assdsdsils lksgislgsp fhltpdqeek pftsnkgpri lkpgekstle
     2161 akkiesenkg ikggkkvyks litgkirsns eissqmkqpl ptnmpsisrg rtmihipglr
     2221 nsssstspvs kkgpplktpa skspsegpga ttsprgtkpa gkselspitr qtsqisgsnk
     2281 gssrsgsrds tpsrptqqpl srpmqspgrn sispgrngis ppnklsqlpr tsspstastk
     2341 ssgsgkmsyt spgrqlsqqn ltkqaslskn assiprsesa skglnqmsng ngsnkkvels
     2401 rmsstkssgs esdrserpal vrqstfikea psptlrrkle esasfeslsp ssrpdsptrs
     2461 qaqtpvlsps lpdmslsthp svqaggwrkl ppnlsptiey ndgrptkrhd iarshsesps
     2521 rlpinragtw krehskhsss lprvstwrrt gssssilsas sessekakse derhvssmpa
     2581 prqmkenqvp tkgtwrkike sdisptgmas qsassgaasg aeskpliyqm appvsktedv
     2641 wvriedcpin nprsgrsptg ntppvidsvs ekgsssikds kdthgkqsvg sgspvqtvgl
     2701 etrlnsfvqv eapeqkgtea kpgqsnpvsi aetaetciae rtpfssssss khsspsgtva
     2761 arvtpfnynp sprkssadst sarpsqiptp vstntkkrds ktdstessga qspkrhsgsy
     2821 lvtsv
//
LOCUS       NP_001405743             135 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 10 [Mus musculus].
ACCESSION   NP_001405743 XP_036017165
VERSION     NP_001405743.1
DBSOURCE    REFSEQ: accession NM_001418814.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 135)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 135)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 135)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 135)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 135)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 135)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 135)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 135)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 135)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 135)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            On Mar 23, 2023 this sequence version replaced XP_036017165.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862051.3216503.1,
                                           SRR17253012.2322717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..135
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..135
                     /product="COMM domain-containing protein 10 isoform 10"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=14564
     Region          15..119
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..135
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418814.1:39..446"
                     /note="isoform 10 is encoded by transcript variant 10"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 maasaalilp espsmkkavp linaidtgrf prllsrilqk lhlkaessfs eeeeeklqaa
       61 fslekqelhl vletisfvle qletvgwqln lqmahsaqak lqspqavlql gvskedaknc
      121 lanitaasac dlcpa
//
LOCUS       NP_001343441             573 aa            linear   ROD 27-AUG-2025
DEFINITION  60 kDa heat shock protein, mitochondrial [Mus musculus].
ACCESSION   NP_001343441 XP_006495769
VERSION     NP_001343441.1
DBSOURCE    REFSEQ: accession NM_001356512.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Li,W., Zhu,W., Zhu,Z., Xie,H., Ali,T., Yu,Z. and Li,S.
  TITLE     Astrocytic-HSP60 Depletion Contributed to Autophagy Defects of
            Astrocytes and Depressive-Like Behaviors in Male Mice
  JOURNAL   Glia 73 (10), 2130-2146 (2025)
   PUBMED   40642774
REFERENCE   2  (residues 1 to 573)
  AUTHORS   Zhu,W., Cheng,Y., Lang,Z., Li,W. and Wei,X.
  TITLE     Astrocytic HSP60 Deletion Induced Astrocyte Senescence and
            Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF
            Pathway
  JOURNAL   J Neurosci Res 103 (6), e70054 (2025)
   PUBMED   40448367
REFERENCE   3  (residues 1 to 573)
  AUTHORS   Liu,D.H., Li,F., Yang,R.Z., Wu,Z., Meng,X.Y., Li,S.M., Li,W.X.,
            Li,J.K., Wang,D.D., Wang,R.Y., Li,S.A., Liu,P.P. and Kang,J.S.
  TITLE     Pulmonary mitochondrial DNA release and activation of the
            cGAS-STING pathway in Lethal Stx12 knockout mice
  JOURNAL   Cell Commun Signal 23 (1), 174 (2025)
   PUBMED   40200300
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 573)
  AUTHORS   Li,W., Luo,Y., Ali,T., Huang,Y., Yu,Z.J., Hao,L. and Li,S.
  TITLE     Hsp60 deletion in cholinergic neurons: Impact on neuroinflammation
            and memory
  JOURNAL   Int Immunopharmacol 141, 113022 (2024)
   PUBMED   39213869
REFERENCE   5  (residues 1 to 573)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   6  (residues 1 to 573)
  AUTHORS   Brudzynski,K., Martinez,V. and Gupta,R.S.
  TITLE     Immunocytochemical localization of heat-shock protein 60-related
            protein in beta-cell secretory granules and its altered
            distribution in non-obese diabetic mice
  JOURNAL   Diabetologia 35 (4), 316-324 (1992)
   PUBMED   1516759
REFERENCE   7  (residues 1 to 573)
  AUTHORS   Ikawa,S. and Weinberg,R.A.
  TITLE     An interaction between p21ras and heat shock protein hsp60, a
            chaperonin
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2012-2016 (1992)
   PUBMED   1347942
REFERENCE   8  (residues 1 to 573)
  AUTHORS   Elias,D., Reshef,T., Birk,O.S., van der Zee,R., Walker,M.D. and
            Cohen,I.R.
  TITLE     Vaccination against autoimmune mouse diabetes with a T-cell epitope
            of the human 65-kDa heat shock protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3088-3091 (1991)
   PUBMED   1707531
REFERENCE   9  (residues 1 to 573)
  AUTHORS   Lotscher,E. and Allison,J.P.
  TITLE     Nucleotide and deduced amino acid sequence of a murine cDNA clone
            encoding one member of the hsp65 multigene family
  JOURNAL   Nucleic Acids Res 18 (23), 7153 (1990)
   PUBMED   2263486
REFERENCE   10 (residues 1 to 573)
  AUTHORS   Venner,T.J. and Gupta,R.S.
  TITLE     Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA
  JOURNAL   Biochim Biophys Acta 1087 (3), 336-338 (1990)
   PUBMED   1979012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108391.14.
            
            On Oct 6, 2017 this sequence version replaced XP_006495769.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.30364.1,
                                           SRR3224858.11364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.01 cM"
     Protein         1..573
                     /product="60 kDa heat shock protein, mitochondrial"
                     /EC_number="5.6.1.7"
                     /note="heat shock 60kDa protein 1 (chaperonin); chaperonin
                     60; 60 kDa chaperonin; heat shock protein 60;
                     mitochondrial matrix protein P1; heat shock protein, 60
                     kDa"
                     /calculated_mol_wt=57926
     transit_peptide 1..26
                     /note="Mitochondrion.
                     /evidence=ECO:0000269|PubMed:7523108; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
                     /calculated_mol_wt=3048
     mat_peptide     27..573
                     /product="60 kDa heat shock protein, mitochondrial.
                     /id=PRO_0000005027"
                     /note="propagated from UniProtKB/Swiss-Prot (P63038.1)"
                     /calculated_mol_wt=57926
     Region          28..548
                     /region_name="GroEL"
                     /note="GroEL_like type I chaperonin. Chaperonins are
                     involved in productive folding of proteins. They share a
                     common general morphology, a double toroid of 2 stacked
                     rings, each composed of 7-9 subunits. The symmetry of type
                     I is seven-fold and they are found...; cd03344"
                     /db_xref="CDD:239460"
     Site            order(28,32,49,60..63,65,70..71,73,83,85,93,97,100,221,
                     253,281,409,411,484,538,541..547)
                     /site_type="other"
                     /note="ring oligomerisation interface [polypeptide
                     binding]"
                     /db_xref="CDD:239460"
     Site            order(55..57,111,115,174,423,440,479,518,520)
                     /site_type="other"
                     /note="ATP/Mg binding site [chemical binding]"
                     /db_xref="CDD:239460"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            82
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            87
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            91
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            125
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            130
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            order(133,459,477,486,488..489,492)
                     /site_type="active"
                     /note="stacking interactions [active]"
                     /db_xref="CDD:239460"
     Site            133
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            156
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            order(165,210,217,400,434..435)
                     /site_type="other"
                     /note="hinge regions"
                     /db_xref="CDD:239460"
     Site            191
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            202
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            205
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            218
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            236
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            249
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            250
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            269
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            292
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            314
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            352
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            359
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            389
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            396
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            455
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            469
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            481
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     CDS             1..573
                     /gene="Hspd1"
                     /gene_synonym="60kDa; CPN60; HSP-60; HSP-65; Hsp60"
                     /coded_by="NM_001356512.1:258..1979"
                     /db_xref="CCDS:CCDS35569.1"
                     /db_xref="GeneID:15510"
                     /db_xref="MGI:MGI:96242"
ORIGIN      
        1 mlrlptvlrq mrpvsralap hltrayakdv kfgadaralm lqgvdllada vavtmgpkgr
       61 tviieqswgs pkvtkdgvtv aksidlkdky knigaklvqd vanntneeag dgtttatvla
      121 rsiakegfek iskganpvei rrgvmlavda viaelkkqsk pvttpeeiaq vatisangdk
      181 digniisdam kkvgrkgvit vkdgktlnde leiiegmkfd rgyispyfin tskgqkcefq
      241 dayvllsekk issvqsivpa leianahrkp lviiaedvdg ealstlvlnr lkvglqvvav
      301 kapgfgdnrk nqlkdmaiat ggavfgeegl nlnledvqah dlgkvgeviv tkddamllkg
      361 kgdkahiekr iqeiteqldi ttseyekekl nerlaklsdg vavlkvggts dvevnekkdr
      421 vtdalnatra aveegivlgg gcallrcipa ldslkpaned qkigieiikr alkipamtia
      481 knagvegsli vekilqssse vgydamlgdf vnmvekgiid ptkvvrtall daagvasllt
      541 taeavvteip keekdpgmga mggmgggmgg gmf
//
LOCUS       NP_001395629            2421 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
            [Mus musculus].
ACCESSION   NP_001395629 XP_030103045
VERSION     NP_001395629.1
DBSOURCE    REFSEQ: accession NM_001408700.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2421)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2421)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2421)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 2421)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 2421)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 2421)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 2421)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 2421)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 2421)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 2421)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            On Jun 22, 2022 this sequence version replaced XP_030103045.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.16033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..2421
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 2"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=266870
     Region          49..164
                     /region_name="PWWP_NSD1_rpt1"
                     /note="first PWWP domain found in nuclear receptor-binding
                     SET domain-containing protein 1 (NSD1) and similar
                     proteins; cd20161"
                     /db_xref="CDD:438989"
     Site            order(65,68,99)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438989"
     Site            66..69
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438989"
     Site            order(137..139,142..143)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438989"
     Region          <1183..1317
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          1276..1317
                     /region_name="PHD1_NSD1_2"
                     /note="PHD finger 1 found in nuclear receptor-binding SET
                     domain-containing protein NSD1 and NSD2; cd15648"
                     /db_xref="CDD:277118"
     Site            order(1276,1285..1289,1294,1312)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277118"
     Region          1323..1369
                     /region_name="PHD2_NSD1"
                     /note="PHD finger 2 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15650"
                     /db_xref="CDD:277120"
     Site            order(1323,1333..1337,1343,1364)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277120"
     Region          1370..1423
                     /region_name="PHD3_NSD1"
                     /note="PHD finger 3 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15653"
                     /db_xref="CDD:277123"
     Site            order(1370,1388..1392,1396,1418)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277123"
     Region          1440..1479
                     /region_name="PHD4_NSD1"
                     /note="PHD finger 4 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15656"
                     /db_xref="CDD:277126"
     Site            order(1440,1449..1453,1457,1474)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277126"
     Region          1486..1581
                     /region_name="PWWP_NSD1_rpt2"
                     /note="second PWWP domain found in nuclear
                     receptor-binding SET domain-containing protein 1 (NSD1)
                     and similar proteins; cd20164"
                     /db_xref="CDD:438992"
     Site            order(1498,1501,1529)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438992"
     Site            1499..1502
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438992"
     Region          1632..1670
                     /region_name="AWS"
                     /note="AWS domain; pfam17907"
                     /db_xref="CDD:465559"
     Region          1672..1813
                     /region_name="SET_NSD1"
                     /note="SET domain (including post-SET domain) found in
                     nuclear receptor-binding SET domain-containing protein 1
                     (NSD1) and similar proteins; cd19210"
                     /db_xref="CDD:380987"
     Site            order(1683..1685,1702,1712,1716,1725..1731,1748..1752,
                     1759..1761,1776,1787..1797,1799..1803,1812)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380987"
     Site            order(1683..1685,1725..1728,1748..1752,1789,1796,
                     1800..1803,1812)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380987"
     Site            order(1702,1712,1716,1727..1731,1759..1761,1776,
                     1787..1791)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:380987"
     Site            order(1754,1801,1803,1808)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:380987"
     Region          1851..1893
                     /region_name="PHD5_NSD1"
                     /note="PHD finger 5 found in nuclear receptor-binding SET
                     domain-containing protein 1 (NSD1); cd15659"
                     /db_xref="CDD:277129"
     Site            order(1851,1860..1864,1870,1888)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277129"
     Region          1892..1941
                     /region_name="C5HCH"
                     /note="NSD Cys-His rich domain; pfam17982"
                     /db_xref="CDD:465605"
     Region          1985..>2306
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..2421
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408700.1:349..7614"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mppktrtals ddpdsspspl gnmleipgts spstsqelpf cqpkkkstpl kyevgdliwa
       61 kfkrrpwwpc ricsdplint hskmkvanrr pyreyyveaf gdpsekawva gkaivmfegr
      121 hqfeelpvlr krgkqkekgy rhkvpqkils kweasvglae qydvpkgskn qkcvsssvkl
      181 dseedmpfed ctndpdsehl llngclksla fdsehsadek ekpcaksrvr kssdnikrts
      241 vkkdlvpfes rkeerrgkip dnlgldfisg gvsdkqasne lsriansltg sstapgsflf
      301 sssvqntakt dfetpdcdsl sglsesalis khsgekkklq pgqvcsskvq lcyvgagdee
      361 krsnsvsvst tsddgcsdld ptehnsgfqn svlgitdafd ktenalsvhk netqysrypv
      421 tnrikekqks litnshadhl mgstktmepe taelsqvnls dlkisspipk pqpefrndgl
      481 ttkfsappgi rnenpltkgg lanqtllplk crqpkfrsik ckhkespava etsatsedls
      541 lkccssdtng splanisksg kgeglkllnn mhektrdssd ietavvkhvl selkelsyrs
      601 lsedvsdsgt akaskpllfs sassqnhipi epdykfstll mmlkdmhdsk tkeqrlmtaq
      661 nlasyrtpdr gdcssgspvg tskvlvlgss tpnsekpgds tqdsvhqspg ggdsalsgel
      721 ssslsslasd krelpacgki rsnciprrnc grakpssklr etisaqmvkp svnpkalkte
      781 rkrkfsrlpa vtlaanrlgn kesgsvngps rggaedpgke eplqqmdllr nedthfsdvh
      841 fdskakqsdp dknlekepsf enrkgpelgs emntendelh gvnqvvpkkr wqrlnqrrpk
      901 pgkranrfre kensegafgv llpadavqka redyleqrap ptskpedsaa dpnhgshses
      961 vaprlnvcek ssvgmgdvek etgipslmpq tklpepairs ekkrlrkpsk wlleyteeyd
     1021 qifapkkkqk kvqeqvhkvs srcedeslla rcqpsaqnkq vdenslistk eeppvlerea
     1081 pflegplaqs dlgvthaelp qltlsvpvap easprpales eellvktpgn yeskrqrkpt
     1141 kkllesndld pgfmpkkgdl glsrkcfeas rsgngivesr atshlkefsg gttkifdkpr
     1201 krkrqrlvta rvhykkvkke dltkdtpsse gellihrtaa spkeileegv ehdpgmsask
     1261 klqverggga alkenvcqnc eklgelllce aqccgafhle clglpemprg kficnechtg
     1321 ihtcfvckqs gedvkrcllp lcgkfyheec vqkypptvtq nkgfrcplhi citchaanpa
     1381 nvsaskgrlm rcvrcpvayh andfclaags kilasnsiic pnhftprrgc rnhehvnvsw
     1441 cfvcseggsl lccdscpaaf hreclnidip egnwycndck agkkphyrei vwvkvgryrw
     1501 wpaeichpra vpsnidkmrh dvgefpvlff gsndylwthq arvfpymegd vsskdkmgkg
     1561 vdgtykkalq eaaarfeelk aqkelrqlqe drkndkkppp ykhikvnrpi grvqiftadl
     1621 seiprcncka tdenpcgids ecinrmllye chptvcpagv rcqnqcfskr qypdveifrt
     1681 lqrgwglrtk tdikkgefvn eyvgelidee ecrariryaq ehditnfyml tldkdriida
     1741 gpkgnyarfm nhccqpncet qkwsvngdtr vglfalsdik agteltfnyn leclgngktv
     1801 ckcgapncsg flgvrpknqp ivteeksrkf krkphgkrrs qgevtkered ecfscgdagq
     1861 lvsckkpgcp kvyhadclnl tkrpagkwec pwhqcdvcgk eaasfcemcp ssfckqhreg
     1921 mlfiskldgr lsctehdpcg pnplepgeir eyvpptatsp pspgtqpkeq ssematqgpk
     1981 ksdqpptdat qllplskkal tgscqrpllp erppertdss shlldrirdl agsgtksqsl
     2041 vssqrpqdrp pakegprpqp pdraspmtrp ssspsvsslp lerplrmtds rldksigaas
     2101 pksqavektp astglrlssp drllttnspk pqisdrppek shasltqrlp ppekvlsavv
     2161 qslvakekal rpvdqntqsk hrpavvmdli dltprqkera aspqevtpqa dektamless
     2221 swpsskglgh ipratekisv seslqpsgkv aapsehpwqa vksltharfl sppsakafly
     2281 esatqasgrt pvgaeqtpgp pspapglvkq vkqlsrglta ksgqsfrslg kisaslpnee
     2341 kklttteqsp wglgkaspga glwpivagqt laqacwsagg tqtlaqtcws lgrgqdpkpe
     2401 naiqalnqap ssrkcadsek k
//
LOCUS       NP_032380                874 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-12 receptor subunit beta-2 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_032380 XP_988441 XP_996313
VERSION     NP_032380.1
DBSOURCE    REFSEQ: accession NM_008354.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 874)
  AUTHORS   Schneeberger,S., Kim,S.J., Geesdorf,M.N., Friebel,E., Eede,P.,
            Jendrach,M., Boltengagen,A., Braeuning,C., Ruhwedel,T.,
            Hulsmeier,A.J., Gimber,N., Foerster,M., Obst,J., Andreadou,M.,
            Mundt,S., Schmoranzer,J., Prokop,S., Kessler,W., Kuhlmann,T.,
            Mobius,W., Nave,K.A., Hornemann,T., Becher,B., Edgar,J.M.,
            Karaiskos,N., Kocks,C., Rajewsky,N. and Heppner,F.L.
  TITLE     Interleukin-12 signaling drives Alzheimer's disease pathology
            through disrupting neuronal and oligodendrocyte homeostasis
  JOURNAL   Nat Aging 5 (4), 622-641 (2025)
   PUBMED   40082619
REFERENCE   2  (residues 1 to 874)
  AUTHORS   Krstanovic,F., Mihalic,A., Rashidi,A.S., Sitnik,K.M., Ruzsics,Z.,
            Cicin-Sain,L., Verjans,G.M.G.M., Jonjic,S. and Brizic,I.
  TITLE     Neuron-restricted cytomegalovirus latency in the central nervous
            system regulated by CD4+ T-cells and IFN-gamma
  JOURNAL   J Neuroinflammation 22 (1), 95 (2025)
   PUBMED   40158177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 874)
  AUTHORS   Solaymani-Mohammadi,S.
  TITLE     The IL-21/IL-21R signaling axis regulates CD4+ T-cell
            responsiveness to IL-12 to promote bacterial-induced colitis
  JOURNAL   J Leukoc Biol 116 (4), 726-737 (2024)
   PUBMED   38498592
REFERENCE   4  (residues 1 to 874)
  AUTHORS   Elsner,R.A., Smita,S. and Shlomchik,M.J.
  TITLE     IL-12 induces a B cell-intrinsic IL-12/IFNgamma feed-forward loop
            promoting extrafollicular B cell responses
  JOURNAL   Nat Immunol 25 (7), 1283-1295 (2024)
   PUBMED   38862796
REFERENCE   5  (residues 1 to 874)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 874)
  AUTHORS   Wu,C., Wang,X., Gadina,M., O'Shea,J.J., Presky,D.H. and Magram,J.
  TITLE     IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective
            in IL-12-mediated signaling despite the presence of high affinity
            IL-12 binding sites
  JOURNAL   J Immunol 165 (11), 6221-6228 (2000)
   PUBMED   11086056
REFERENCE   7  (residues 1 to 874)
  AUTHORS   Galbiati,F., Rogge,L. and Adorini,L.
  TITLE     IL-12 receptor regulation in IL-12-deficient BALB/c and C57BL/6
            mice
  JOURNAL   Eur J Immunol 30 (1), 29-37 (2000)
   PUBMED   10602024
REFERENCE   8  (residues 1 to 874)
  AUTHORS   Himmelrich,H., Parra-Lopez,C., Tacchini-Cottier,F., Louis,J.A. and
            Launois,P.
  TITLE     The IL-4 rapidly produced in BALB/c mice after infection with
            Leishmania major down-regulates IL-12 receptor beta 2-chain
            expression on CD4+ T cells resulting in a state of unresponsiveness
            to IL-12
  JOURNAL   J Immunol 161 (11), 6156-6163 (1998)
   PUBMED   9834101
REFERENCE   9  (residues 1 to 874)
  AUTHORS   Szabo,S.J., Dighe,A.S., Gubler,U. and Murphy,K.M.
  TITLE     Regulation of the interleukin (IL)-12R beta 2 subunit expression in
            developing T helper 1 (Th1) and Th2 cells
  JOURNAL   J Exp Med 185 (5), 817-824 (1997)
   PUBMED   9120387
REFERENCE   10 (residues 1 to 874)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130822.3.
            
            On or before May 4, 2006 this sequence version replaced
            XP_988441.1, XP_996313.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U64199.1, BC137745.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.81 cM"
     Protein         1..874
                     /product="interleukin-12 receptor subunit beta-2 isoform 1
                     precursor"
                     /note="interleukin-12 receptor subunit beta-2; IL-12R
                     subunit beta-2; IL-12 receptor subunit beta-2; interferon
                     response to microorganisms"
                     /calculated_mol_wt=95517
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2698
     mat_peptide     24..874
                     /product="Interleukin-12 receptor subunit beta-2.
                     /id=PRO_0000010921"
                     /note="propagated from UniProtKB/Swiss-Prot (P97378.1)"
                     /calculated_mol_wt=95517
     Region          28..120
                     /region_name="Lep_receptor_Ig"
                     /note="Ig-like C2-type domain; pfam06328"
                     /db_xref="CDD:461878"
     Site            48
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            101
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            114
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            142
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            224
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Region          240..332
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(240,302,320)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            252
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            279
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            287
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Region          321..325
                     /region_name="WSXWS motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P97378.1)"
     Site            order(321..322,324..325)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            323
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Site            391
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Region          438..526
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            495
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97378.1)"
     Region          536..630
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(621..622,624..625)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            638..658
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97378.1)"
     Region          677..685
                     /region_name="Box 1 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P97378.1)"
     Site            757
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine. /evidence=ECO:0000305; propagated
                     from UniProtKB/Swiss-Prot (P97378.1)"
     Site            804
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine. /evidence=ECO:0000305; propagated
                     from UniProtKB/Swiss-Prot (P97378.1)"
     Site            811
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q99665, ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P97378.1)"
     CDS             1..874
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /coded_by="NM_008354.4:189..2813"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS20220.1"
                     /db_xref="GeneID:16162"
                     /db_xref="MGI:MGI:1270861"
ORIGIN      
        1 maqtvrecsl allflfmwll ikanidvckl gtvtvqpapv iplgsaanis cslnpkqgcs
       61 hypssnelil lkfvndvlve nlhgkkvhdh tghsstfqvt nlslgmtlfv cklncsnsqk
      121 kppvpvcgve isvgvapepp qniscvqege ngtvacswns gkvtylktny tlqlsgpnnl
      181 tcqkqcfsdn rqncnrldlg inlspdlaes rfivrvtain dlgnssslph tftfldivip
      241 lppwdirinf lnasgsrgtl qwedegqvvl nqlryqplns tswnmvnatn akgkydlrdl
      301 rpfteyefqi ssklhlsggs wsnwseslrt rtpeeepvgi ldiwymkqdi dydrqqislf
      361 wkslnpsear gkilhyqvtl qevtkkttlq nttrhtswtr viprtgawta svsaanskga
      421 sapthinivd lcgtgllaph qvsaksenmd nilvtwqppk kadsavreyi vewralqpgs
      481 itkfpphwlr ippdnmsali senikpyicy eirvhalses qggcssirgd skhkapvsgp
      541 hitaitekke rlfiswthip fpeqrgcilh yriywkerds taqpelceiq yrrsqnshpi
      601 sslqprvtyv lwmtavtaag espqgneref cpqgkanwka fvissiciai itvgtfsiry
      661 frqkaftlls tlkpqwysrt ipdpanstwv kkypileeki qlptdnllma wptpeepepl
      721 iihevlyhmi pvvrqpyyfk rgqgfqgyst skqdamyian pqatgtltae trqlvnlykv
      781 lesrdpdskl anltspltvt pvnylpsheg ylpsniedls pheadptdsf dlehqhisls
      841 ifassslrpl ifggerltld rlkmgydslm snea
//
LOCUS       NP_001278169             763 aa            linear   ROD 27-AUG-2025
DEFINITION  protein CASP isoform g [Mus musculus].
ACCESSION   NP_001278169 XP_006504420
VERSION     NP_001278169.1
DBSOURCE    REFSEQ: accession NM_001291240.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 763)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 763)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 763)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 763)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 763)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 763)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 763)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 763)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 763)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 763)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Mar 29, 2014 this sequence version replaced XP_006504420.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.35690.1,
                                           SRR13422600.866506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..763
                     /product="protein CASP isoform g"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=85381
     Region          <192..>460
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          508..728
                     /region_name="CASP_C"
                     /note="CASP C terminal; pfam08172"
                     /db_xref="CDD:462392"
     CDS             1..763
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_001291240.2:674..2965"
                     /note="isoform g is encoded by transcript variant 7"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 merasgplra afsspvlesk apgapldcke tdcgsssprg dgigasqsaa elpacpedai
       61 lpatphrnql lalgvlpasa ssafaapgqp qdsarwmlcv agaklkreld atatvlanrq
      121 deseqsrkrl ieqsrefkkn tpedlrkqva pllksfqgei dalskrskea eaafltvykr
      181 lidvpdpvpa ldvgqqleik vqrlhdiete nqklretlee ynkefaevkn qevtikalke
      241 kireyeqtlk sqaetialek eqklqndfae kerklqetqm sttskleeae hklqtlqtal
      301 ektrtelfdl ktkydeetta kadeiemimt dleranqrae vaqreaetlr eqlssanhsl
      361 qlasqiqkap dveqaievlt rsslevelaa kereiaqlve dvqrlqaslt klrensasqi
      421 sqleqqlnak nstlkqleek lkgqadyeev kkelntlksm efapsegagt qdstkplevl
      481 lleknrslqs enatlrisns dlsgrcaelq ihlteataka veqkeliarl eqdlstiqsi
      541 qrpdaegase qglekipepi keatalfygp smsssgtlpe gqvdsllsii ssqrerfrtr
      601 nqeleaesrm aqhtiqalqs eldslradni klfekikflq sypgrgigsd dtelryssqy
      661 eerldpfssf skrerqrkyl glspwdkatl gmgrlilsnk martisffyt lflhclvflv
      721 lyklawsesv erdcaatcak kfadhlhkfh esdngaaagd lwq
//
LOCUS       NP_001296566             199 aa            linear   ROD 27-AUG-2025
DEFINITION  C-type lectin domain family 7 member A isoform 2 [Mus musculus].
ACCESSION   NP_001296566
VERSION     NP_001296566.1
DBSOURCE    REFSEQ: accession NM_001309637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 199)
  AUTHORS   Qiu,D., Zhang,S., Huang,C., Wang,X., Deng,J., Sun,H., Feng,B.,
            Tan,Y., Ji,K., Xu,S., Ye,X., Cheng,C., Kakuta,S., Adachi,Y.,
            Iwakura,Y., Wang,S., Dong,S. and Tang,C.
  TITLE     Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis
  JOURNAL   Immunity 58 (7), 1811-1829 (2025)
   PUBMED   40494347
REFERENCE   2  (residues 1 to 199)
  AUTHORS   McKinsey,G.L., Santander,N., Zhang,X., Kleemann,K.L., Tran,L.,
            Katewa,A., Conant,K., Barraza,M., Waddell,K., Lizama,C.O., La
            Russa,M., Koo,J.H., Lee,H., Mukherjee,D., Paidassi,H., Anton,E.S.,
            Atabai,K., Sheppard,D., Butovsky,O. and Arnold,T.D.
  TITLE     Radial glia integrin avb8 regulates cell autonomous microglial
            TGFbeta1 signaling that is necessary for microglial identity
  JOURNAL   Nat Commun 16 (1), 2840 (2025)
   PUBMED   40121230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 199)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   4  (residues 1 to 199)
  AUTHORS   Murphy,B., Miyamoto,T., Manning,B.S., Mirji,G., Ugolini,A.,
            Kannan,T., Hamada,K., Zhu,Y.P., Claiborne,D.T., Huang,L., Zhang,R.,
            Nefedova,Y., Kossenkov,A., Veglia,F., Shinde,R. and Zhang,N.
  TITLE     Myeloid activation clears ascites and reveals IL27-dependent
            regression of metastatic ovarian cancer
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39570374
  REMARK    Erratum:[J Exp Med. 2025 Apr 7;222(4):e2023196702272025c. doi:
            10.1084/jem.2023196702272025c. PMID: 40067151]
REFERENCE   5  (residues 1 to 199)
  AUTHORS   Guibo,L., Chunxu,D., Biao,C., Zhaolei,H., Wenwen,L., Xiangnan,J.,
            Wentao,P., Hongmin,C., Yonghua,L. and Guoqiang,Z.
  TITLE     Dectin-1 participates in the immune-inflammatory response to mouse
            Aspergillus fumigatus keratitis by modulating macrophage
            polarization
  JOURNAL   Front Immunol 15, 1431633 (2024)
   PUBMED   39478855
  REMARK    GeneRIF: Dectin-1 participates in the immune-inflammatory response
            to mouse Aspergillus fumigatus keratitis by modulating macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 199)
  AUTHORS   Brown,G.D., Taylor,P.R., Reid,D.M., Willment,J.A., Williams,D.L.,
            Martinez-Pomares,L., Wong,S.Y. and Gordon,S.
  TITLE     Dectin-1 is a major beta-glucan receptor on macrophages
  JOURNAL   J Exp Med 196 (3), 407-412 (2002)
   PUBMED   12163569
REFERENCE   7  (residues 1 to 199)
  AUTHORS   Brown,G.D. and Gordon,S.
  TITLE     Immune recognition. A new receptor for beta-glucans
  JOURNAL   Nature 413 (6851), 36-37 (2001)
   PUBMED   11544516
REFERENCE   8  (residues 1 to 199)
  AUTHORS   Yokota,K., Takashima,A., Bergstresser,P.R. and Ariizumi,K.
  TITLE     Identification of a human homologue of the dendritic
            cell-associated C-type lectin-1, dectin-1
  JOURNAL   Gene 272 (1-2), 51-60 (2001)
   PUBMED   11470510
REFERENCE   9  (residues 1 to 199)
  AUTHORS   Hermanz-Falcon,P., Arce,I., Roda-Navarro,P. and Fernandez-Ruiz,E.
  TITLE     Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene
            expressed on dendritic cells
  JOURNAL   Immunogenetics 53 (4), 288-295 (2001)
   PUBMED   11491532
  REMARK    Erratum:[Immunogenetics 2001 Aug;53(6):518]
REFERENCE   10 (residues 1 to 199)
  AUTHORS   Ariizumi,K., Shen,G.L., Shikano,S., Xu,S., Ritter,R. 3rd,
            Kumamoto,T., Edelbaum,D., Morita,A., Bergstresser,P.R. and
            Takashima,A.
  TITLE     Identification of a novel, dendritic cell-associated molecule,
            dectin-1, by subtractive cDNA cloning
  JOURNAL   J Biol Chem 275 (26), 20157-20167 (2000)
   PUBMED   10779524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138620.4, BY750022.1 and AA240643.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The encoded
            isoform (2) is shorter, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.84174.1, BE306741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.34 cM"
     Protein         1..199
                     /product="C-type lectin domain family 7 member A isoform
                     2"
                     /note="C-type (calcium dependent, carbohydrate recognition
                     domain) lectin, superfamily member 12; dectin-1;
                     DC-associated C-type lectin 1; C-type lectin superfamily
                     member 12; dendritic cell-associated C-type lectin 1;
                     beta-glucan receptor"
                     /calculated_mol_wt=22292
     Region          74..197
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(132,160,181,183..184)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /coded_by="NM_001309637.2:101..700"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS85170.1"
                     /db_xref="GeneID:56644"
                     /db_xref="MGI:MGI:1861431"
ORIGIN      
        1 mkyhshienl dedgytqldf stqdihkrpr gsekgsqaps spwrpiavgl gilcfvvvvv
       61 aavlgalggf sqpclpnwim hgkscylfsf sgnswygskr hcsqlgahll kidnskefef
      121 iesqtsshri nafwiglsrn qsegpwfwed gsaffpnsfq vrntapqesl lhncvwihgs
      181 evynqicnts sysicekel
//
LOCUS       NP_001300983             165 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-6 isoform 2 precursor [Mus musculus].
ACCESSION   NP_001300983
VERSION     NP_001300983.1
DBSOURCE    REFSEQ: accession NM_001314054.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 165)
  AUTHORS   Xing,C., Duan,T., Li,L., Chen,L., Zhang,P., Du,Y., Liu,S.,
            Annaparthi,N., Wang,S., Qian,C., Wang,H.Y. and Wang,R.F.
  TITLE     TH17 cells regulate chemokine expression in epithelial cells
            through C/EBPbeta and dictate host sensitivity to colitis and
            cancer immunity
  JOURNAL   Sci Adv 11 (31), eads3530 (2025)
   PUBMED   40749055
REFERENCE   2  (residues 1 to 165)
  AUTHORS   Gonzalez-Vila,A., Ibrahim-Alasoufi,A.M., Luengo-Mateos,M.,
            Pardo-Garcia,V., Diaz-Lopez,A., Fernandez-Rodriguez,B.,
            Poutanen,M., Ohlsson,C., Tena-Sempere,M., Dieguez-Gonzalez,C.,
            Garcia-Garcia,M.D.C. and Barca-Mayo,O.
  TITLE     IL-6 decodes sex and diet-dependent circadian and metabolic rhythms
  JOURNAL   Mol Metab 97, 102171 (2025)
   PUBMED   40412648
  REMARK    Erratum:[Mol Metab. 2025 Sep;99:102198. doi:
            10.1016/j.molmet.2025.102198. PMID: 40617253]
REFERENCE   3  (residues 1 to 165)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 165)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   5  (residues 1 to 165)
  AUTHORS   Kong,W., Lu,W.J., Dubey,M., Suryawanshi,R.K., Vijayakumar,S.,
            Jeong,Y., Gombar,S., Diehn,M., Shin,K., Ott,M., Chien,Y.H.,
            Sarin,K.Y., Desai,T.J. and Beachy,P.A.
  TITLE     Neuroendocrine cells orchestrate regeneration through Desert
            hedgehog signaling
  JOURNAL   Cell (2025) In press
   PUBMED   40494346
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 165)
  AUTHORS   Chin,H., Mock,B., Kim,H.L., Kim,H. and Kozak,C.A.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (residues 1 to 165)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   8  (residues 1 to 165)
  AUTHORS   Vandevoorde,V., Haegeman,G. and Fiers,W.
  TITLE     TNF-mediated IL6 gene expression and cytotoxicity are co-inducible
            in TNF-resistant L929 cells
  JOURNAL   FEBS Lett 302 (3), 235-238 (1992)
   PUBMED   1318227
REFERENCE   9  (residues 1 to 165)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   10 (residues 1 to 165)
  AUTHORS   Bodine,D.M., Orlic,D., Birkett,N.C., Seidel,N.E. and Zsebo,K.M.
  TITLE     Stem cell factor increases colony-forming unit-spleen number in
            vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as
            a single factor
  JOURNAL   Blood 79 (4), 913-919 (1992)
   PUBMED   1371079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112933.16, BC145409.1 and
            AK150440.1.
            
            Summary: This gene encodes a member of the interleukin family of
            cytokines that have important functions in immune response,
            hematopoiesis, inflammation and the acute phase response. The
            ectopic overexpression of the encoded protein in mice results in
            excessive plasma cells in circulation, leading to death. Mice
            lacking the encoded protein exhibit abnormalities in hepatic acute
            phase response, some immune mechanisms, bone resorption in response
            to estrogen, liver regeneration and wound healing. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' terminal exon, compared to variant 1. The encoded protein
            (isoform 2) is shorter and has a distinct C-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095721, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.7 cM"
     Protein         1..165
                     /product="interleukin-6 isoform 2 precursor"
                     /note="interleukin HP-1; B-cell hybridoma growth factor"
                     /calculated_mol_wt=16370
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2667
     Region          27..>157
                     /region_name="IL6"
                     /note="Interleukin-6/G-CSF/MGF family; cl02473"
                     /db_xref="CDD:413331"
     CDS             1..165
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /coded_by="NM_001314054.1:79..576"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS84856.1"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
ORIGIN      
        1 mkflsardfh pvaflglmlv tttafptsqv rrgdftedtt pnrpvyttsq vgglithvlw
       61 eivemrkelc ngnsdcmnnd dalaennlkl peiqrndgcy qtgynqeicl lkissglley
      121 hsyleymknn lkdnkkdkar vlqrdtetli hifnqeisws hrrsg
//
LOCUS       NP_001334107             366 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform e [Mus musculus].
ACCESSION   NP_001334107 XP_017175481
VERSION     NP_001334107.1
DBSOURCE    REFSEQ: accession NM_001347178.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On Nov 17, 2016 this sequence version replaced XP_017175481.1.
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (e)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2143166.1,
                                           SRR7652917.957195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..366
                     /product="ELAV-like protein 4 isoform e"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40218
     Region          43..365
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..366
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001347178.1:287..1387"
                     /note="isoform e is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS84777.1"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mvmiistmep qvsngptsnt sngpssnnrn cpspmqtgaa tddsktnliv nylpqnmtqe
       61 efrslfgsig eiescklvrd kitgqslgyg fvnyidpkda ekaintlngl rlqtktikvs
      121 yarpssasir danlyvsglp ktmtqkeleq lfsqygriit srilvdqvtg vsrgvgfirf
      181 dkrieaeeai kglngqkpsg atepitvkfa nnpsqkssqa llsqlyqspn rrypgplhhq
      241 aqrfrldnll nmaygvkrfs pitidgmtsl vgmnipghtg tgwcifvynl spdsdesvlw
      301 qlfgpfgavn nvkvirdfnt nkckgfgfvt mtnydeaama iaslngyrlg drvlqvsfkt
      361 nkahks
//
LOCUS       NP_001408080             373 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform g [Mus musculus].
ACCESSION   NP_001408080 XP_036019626
VERSION     NP_001408080.1
DBSOURCE    REFSEQ: accession NM_001421151.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 373)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 373)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 373)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 373)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 373)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_036019626.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.76081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415124, SAMN02415125
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..373
                     /product="ELAV-like protein 4 isoform g"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40988
     Region          50..372
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..373
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421151.1:409..1530"
                     /note="isoform g is encoded by transcript variant 7"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mpnallfqcl iistmepqvs ngptsntsng pssnnrncps pmqtgaatdd sktnlivnyl
       61 pqnmtqeefr slfgsigeie scklvrdkit gqslgygfvn yidpkdaeka intlnglrlq
      121 tktikvsyar pssasirdan lyvsglpktm tqkeleqlfs qygriitsri lvdqvtgvsr
      181 gvgfirfdkr ieaeeaikgl ngqkpsgate pitvkfannp sqkssqalls qlyqspnrry
      241 pgplhhqaqr frldnllnma ygvkrfspit idgmtslvgm nipghtgtgw cifvynlspd
      301 sdesvlwqlf gpfgavnnvk virdfntnkc kgfgfvtmtn ydeaamaias lngyrlgdrv
      361 lqvsfktnka hks
//
LOCUS       NP_034641                477 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon gamma receptor 1 precursor [Mus musculus].
ACCESSION   NP_034641
VERSION     NP_034641.1
DBSOURCE    REFSEQ: accession NM_010511.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Risley,C.A., Schultz,M.D., Allie,S.R., Liu,S., Peel,J.N.,
            Nellore,A., Fucile,C.F., Scharer,C.D., Boss,J.M., Randall,T.D.,
            Rosenberg,A.F. and Lund,F.E.
  TITLE     Transcription factor T-bet regulates the maintenance and
            differentiation potential of lymph node and lung effector memory B
            cell subsets
  JOURNAL   Immunity 58 (7), 1706-1724 (2025)
   PUBMED   40543512
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Van Roy,Z., Kak,G., Fallet,R.W. and Kielian,T.
  TITLE     Interferon-gamma receptor signaling regulates innate immunity
            during Staphylococcus aureus craniotomy infection
  JOURNAL   J Neuroinflammation 22 (1), 46 (2025)
   PUBMED   39987156
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell 188 (4), 1019-1035 (2025)
   PUBMED   39708807
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Brandao,W., Jain,N., Yin,Z., Kleemann,K.L., Carpenter,M., Bao,X.,
            Serrano,J.R., Tycksen,E., Durao,A., Barry,J.L., Baufeld,C.,
            Guneykaya,D., Zhang,X., Litvinchuk,A., Jiang,H., Rosenzweig,N.,
            Pitts,K.M., Aronchik,M., Yahya,T., Cao,T., Takahashi,M.K.,
            Krishnan,R., Davtyan,H., Ulrich,J.D., Blurton-Jones,M., Ilin,I.,
            Weiner,H.L., Holtzman,D.M. and Butovsky,O.
  TITLE     Inhaled xenon modulates microglia and ameliorates disease in mouse
            models of amyloidosis and tauopathy
  JOURNAL   Sci Transl Med 17 (781), eadk3690 (2025)
   PUBMED   39813317
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Kozak,C.A., Peyser,M., Krall,M., Mariano,T.M., Kumar,C.S.,
            Pestka,S. and Mock,B.A.
  TITLE     Molecular genetic markers spanning mouse chromosome 10
  JOURNAL   Genomics 8 (3), 519-524 (1990)
   PUBMED   1981053
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Cofano,F., Moore,S.K., Tanaka,S., Yuhki,N., Landolfo,S. and
            Appella,E.
  TITLE     Affinity purification, peptide analysis, and cDNA sequence of the
            mouse interferon gamma receptor
  JOURNAL   J Biol Chem 265 (7), 4064-4071 (1990)
   PUBMED   2137461
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Munro,S. and Maniatis,T.
  TITLE     Expression cloning of the murine interferon gamma receptor cDNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9248-9252 (1989)
   PUBMED   2531896
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Gray,P.W., Leong,S., Fennie,E.H., Farrar,M.A., Pingel,J.T.,
            Fernandez-Luna,J. and Schreiber,R.D.
  TITLE     Cloning and expression of the cDNA for the murine interferon gamma
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8497-8501 (1989)
   PUBMED   2530582
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Kumar,C.S., Muthukumaran,G., Frost,L.J., Noe,M., Ahn,Y.H.,
            Mariano,T.M. and Pestka,S.
  TITLE     Molecular characterization of the murine interferon gamma receptor
            cDNA
  JOURNAL   J Biol Chem 264 (30), 17939-17946 (1989)
   PUBMED   2530216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY754033.1, AK151079.1 and BU700524.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26711.1, AK087525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 8.49 cM"
     Protein         1..477
                     /product="interferon gamma receptor 1 precursor"
                     /note="IFN-gamma-R1; IFN-gamma receptor 1; INF-g receptor;
                     IFN-gamma-R-alpha; interferon gamma receptor alpha-chain"
                     /calculated_mol_wt=49891
     sig_peptide     1..25
                     /note="/evidence=ECO:0000269|PubMed:2137461; propagated
                     from UniProtKB/Swiss-Prot (P15261.3)"
                     /calculated_mol_wt=2471
     Region          9..119
                     /region_name="Tissue_fac"
                     /note="Tissue factor; pfam01108"
                     /db_xref="CDD:460067"
     mat_peptide     26..477
                     /product="Interferon gamma receptor 1.
                     /evidence=ECO:0000269|PubMed:2137461. /id=PRO_0000011010"
                     /note="propagated from UniProtKB/Swiss-Prot (P15261.3)"
                     /calculated_mol_wt=49891
     Site            61
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            85
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Region          168..324
                     /region_name="IFNGR1"
                     /note="Interferon gamma receptor (IFNGR1); pfam07140"
                     /db_xref="CDD:284538"
     Site            255..275
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P15261.3)"
     Region          335..386
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15261.3)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            375
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Region          402..446
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15261.3)"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     Site            445
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P15260; propagated from
                     UniProtKB/Swiss-Prot (P15261.3)"
     CDS             1..477
                     /gene="Ifngr1"
                     /gene_synonym="CD119; Ifgr; IFN-gammaR; Ifngr; Nktar"
                     /coded_by="NM_010511.3:138..1571"
                     /db_xref="CCDS:CCDS35856.1"
                     /db_xref="GeneID:15979"
                     /db_xref="MGI:MGI:107655"
ORIGIN      
        1 mgpqaaagrm illvvlmlsa kvgsgaltst edpeppsvpv ptnvliksyn lnpvvcweyq
       61 nmsqtpiftv qvkvysgswt dsctnisdhc cniyeqimyp dvsawarvka kvgqkesdya
      121 rskeflmclk gkvgppglei rrkkeeqlsv lvfhpevvvn gesqgtmfgd gstcytfdyt
      181 vyvehnrsge ilhtkhtvek eecnetlcel nisvstldsr ycisvdgiss fwqvrteksk
      241 dvcippfhdd rkdsiwilvv apltvftvvi lvfaywytkk nsfkrksiml pksllsvvks
      301 atletkpesk yslvtphqpa vlesetvice eplstvtapd speaaeqeel sketkaleag
      361 gstsamtpds pptptqrrsf sllssnqsgp csltayhsrn gsdsglvgsg ssisdleslp
      421 nnnsetkmae hdpppvrkap masgydkphm lvdvlvdvgg keslmgyrlt geaqels
//
LOCUS       NP_001396745             746 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 1 [Mus musculus].
ACCESSION   NP_001396745
VERSION     NP_001396745.1
DBSOURCE    REFSEQ: accession NM_001409816.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 746)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 746)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 746)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 746)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 746)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 746)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 746)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 746)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 746)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 746)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1056229.1,
                                           SRR13861905.1493573.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..746
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     1"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85161
     Region          1..340
                     /region_name="Interaction with DNMT1, DNMT3A and DNMT3B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          329..522
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          340..426
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            487
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          559..590
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          609..728
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(613,615..618,620,624,627,629,679..680,683,703,719)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(621..624,641,648,651..652,655,659,662..668,685..689,
                     697,724,726..727)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..689,726)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..688)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(641,648,651..652,655,659,664,666..668,697,724,
                     726..728)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..746
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409816.1:96..2336"
                     /note="isoform 1 is encoded by transcript variant 9"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhpfh
      301 atpntykrkn tetaldnkpc gpqcyqhleg akefaaalta eriktppkrp ggrrrgrlpn
      361 nssrpstpti svleskdtds dreagtetgg enndkeeeek kdetssssea nsrcqtpikm
      421 kpnieppenv ewsgaeasmf rvligtyydn fcaiarligt ktcrqvyefr vkessiiapv
      481 ptedvdtppr kkkrkhrlwa ahcrkiqlkk dgssnhvyny qpcdhprqpc dsscpcviaq
      541 nfcekfcqcs secqnrfpgc rckaqcntkq cpcylavrec dpdlcltcga adhwdsknvs
      601 ckncsiqrgs kkhlllapsd vagwgifikd pvqknefise ycgeiisqde adrrgkvydk
      661 ymcsflfnln ndfvvdatrk gnkirfanhs vnpncyakvm mvngdhrigi fakraiqtge
      721 elffdyrysq adalkyvgie remeip
//
LOCUS       NP_001186082             965 aa            linear   ROD 27-AUG-2025
DEFINITION  synphilin-1 isoform 1 [Mus musculus].
ACCESSION   NP_001186082
VERSION     NP_001186082.1
DBSOURCE    REFSEQ: accession NM_001199153.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 965)
  AUTHORS   Dutta,D., Paidi,R.K., Raha,S., Roy,A., Chandra,S. and Pahan,K.
  TITLE     Treadmill exercise reduces alpha-synuclein spreading via PPARalpha
  JOURNAL   Cell Rep 40 (2), 111058 (2022)
   PUBMED   35830804
  REMARK    GeneRIF: Treadmill exercise reduces alpha-synuclein spreading via
            PPARalpha.
            Erratum:[Cell Rep. 2024 Aug 27;43(8):114546. doi:
            10.1016/j.celrep.2024.114546. PMID: 39024097]
REFERENCE   2  (residues 1 to 965)
  AUTHORS   Won,S.Y., Park,J.J., You,S.T., Hyeun,J.A., Kim,H.K., Jin,B.K.,
            McLean,C., Shin,E.Y. and Kim,E.G.
  TITLE     p21-activated kinase 4 controls the aggregation of alpha-synuclein
            by reducing the monomeric and aggregated forms of alpha-synuclein:
            involvement of the E3 ubiquitin ligase NEDD4-1
  JOURNAL   Cell Death Dis 13 (6), 575 (2022)
   PUBMED   35773260
  REMARK    GeneRIF: p21-activated kinase 4 controls the aggregation of
            alpha-synuclein by reducing the monomeric and aggregated forms of
            alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 965)
  AUTHORS   Chen,D.D., Gao,L.P., Wu,Y.Z., Chen,J., Hu,C., Xiao,K., Chen,C.,
            Shi,Q. and Dong,X.P.
  TITLE     Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells
  JOURNAL   ACS Chem Neurosci 12 (20), 3838-3854 (2021)
   PUBMED   34595918
  REMARK    GeneRIF: Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells.
REFERENCE   4  (residues 1 to 965)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 965)
  AUTHORS   Han,J.Y., Shin,C. and Choi,Y.P.
  TITLE     Preclinical Detection of Alpha-Synuclein Seeding Activity in the
            Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
  JOURNAL   Viruses 13 (5), 759 (2021)
   PUBMED   33926043
  REMARK    GeneRIF: Preclinical Detection of Alpha-Synuclein Seeding Activity
            in the Colon of a Transgenic Mouse Model of Synucleinopathy by
            RT-QuIC.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 965)
  AUTHORS   Soehn,A.S., Franck,T., Biskup,S., Giaime,E., Melle,C., Rott,R.,
            Cebo,D., Kalbacher,H., Ott,E., Pahnke,J., Meitinger,T., Kruger,R.,
            Gasser,T., Berg,D., von Eggeling,F., Engelender,S., da Costa,C.A.
            and Riess,O.
  TITLE     Periphilin is a novel interactor of synphilin-1, a protein
            implicated in Parkinson's disease
  JOURNAL   Neurogenetics 11 (2), 203-215 (2010)
   PUBMED   19730898
REFERENCE   7  (residues 1 to 965)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   8  (residues 1 to 965)
  AUTHORS   Kuhn,K., Zhu,X.R., Lubbert,H. and Stichel,C.C.
  TITLE     Parkin expression in the developing mouse
  JOURNAL   Brain Res Dev Brain Res 149 (2), 131-142 (2004)
   PUBMED   15063093
REFERENCE   9  (residues 1 to 965)
  AUTHORS   Goldberg,M.S., Fleming,S.M., Palacino,J.J., Cepeda,C., Lam,H.A.,
            Bhatnagar,A., Meloni,E.G., Wu,N., Ackerson,L.C., Klapstein,G.J.,
            Gajendiran,M., Roth,B.L., Chesselet,M.F., Maidment,N.T.,
            Levine,M.S. and Shen,J.
  TITLE     Parkin-deficient mice exhibit nigrostriatal deficits but not loss
            of dopaminergic neurons
  JOURNAL   J Biol Chem 278 (44), 43628-43635 (2003)
   PUBMED   12930822
REFERENCE   10 (residues 1 to 965)
  AUTHORS   O'Farrell,C., Pickford,F., Vink,L., McGowan,E. and Cookson,M.R.
  TITLE     Sequence conservation between mouse and human synphilin-1
  JOURNAL   Neurosci Lett 322 (1), 9-12 (2002)
   PUBMED   11958831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121943.3 and AC124178.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160111.1, BC098489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..965
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.27 cM"
     Protein         1..965
                     /product="synphilin-1 isoform 1"
                     /note="alpha-synuclein-interacting protein; synphilin-1"
                     /calculated_mol_wt=105850
     mat_peptide     1..962
                     /product="Synphilin-1. /id=PRO_0000320071"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
                     /calculated_mol_wt=105607
     Region          80..99
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          104..137
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          222..249
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          <321..508
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(348,350,354..355,358..360,362..363,367,372,381,383,
                     385,424..425,428..430,432..433,437,444,453,455,457,
                     461..462,465..467,469..470,474,477,486)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          348..381
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          348..379
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          383..453
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          383..412
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          418..447
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          455..486
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          455..484
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          511..554
                     /region_name="SNCAIP_SNCA_bd"
                     /note="Synphilin-1 alpha-Synuclein-binding domain;
                     pfam16700"
                     /db_xref="CDD:435527"
     Region          548..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          602..631
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          667..852
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     CDS             1..965
                     /gene="Sncaip"
                     /gene_synonym="2810407O15Rik; 4933427B05Rik; SYPH1"
                     /coded_by="NM_001199153.2:191..3088"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS57124.1"
                     /db_xref="GeneID:67847"
                     /db_xref="MGI:MGI:1915097"
ORIGIN      
        1 meapeyldld eidfsddisy svtslktipa lcrrcdsqne drsvsssgwn cgvstlitnp
       61 qkptgiadvy skfrpvkrvs plkhqpetle nnenedqknn tveyqkgget dqgpqpeels
      121 pedgvgglpg kgsepsqalg elehydldmd eildvpyiks sqqlapltkv tsekrilglc
      181 ttinglsakt cpiastenst pnmtpfcvls pvksphlrka ptalrdqhkl stedsesspa
      241 lgkcgpayes enhskdflnk vfsdphsrki eksgpdcklr sfhlqssaag akteepingm
      301 nwtntqgtee rteylkkvrs ilnivnegqi sllphlaadn ldkihdengn nllhiaaskg
      361 haeclqhlts lmgedclner nteqltpagl aikngqlecv rwmvseteai aelscskdfp
      421 slihyagcyg qekillwllq fmqeqgisld evdregnsav hvasqhgylg ciqtlveyga
      481 nvtmqnhage kpsqsaerhg htlcsrylvv vetcmslasq vvkltkqlke qtvervtlqs
      541 qlqqlleaqk segkslpssp sspsspastk sqwkaldtde estgkskvga qegiqvlgsl
      601 svssrartkg kdedsdkilr qllgkeisen vctqeklsle fqdaqassrn skkiplekre
      661 lklarlrqlm qrslsesdtd snnsedpknt pvkradrprp qpivesvenv dsaeslhlmi
      721 kkhslasgrr fpfgmkasks ldghspspts essepdldsh gpglgmtppt qpsteatqss
      781 pdstaaqkva tspksalksp sskrrtsqns klrvtfeepv vqmeqtglel ngekdkdkgr
      841 apqrtsesge qmkrpfgtfr simeslsgnq nnnnnyqpas qlktctlplt slgrktadak
      901 gnpvspaskg knkaamyssc ihlpsnalve ehlrdyarhn dikrnatkty hmkhtaepep
      961 relfl
//
LOCUS       NP_031982                599 aa            linear   ROD 27-AUG-2025
DEFINITION  estrogen receptor isoform 1 [Mus musculus].
ACCESSION   NP_031982 XP_990728 XP_990766 XP_990798
VERSION     NP_031982.1
DBSOURCE    REFSEQ: accession NM_007956.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Zha,X., Liu,X.Y., Wang,L., Li,S.S., Sun,Y.Z., Lin,J.K., Yan,J.J.,
            Gao,M.T., Zhang,Y.L., Yang,R.R., Xu,C. and Xu,X.H.
  TITLE     Estrogen signaling in the ventromedial hypothalamus is required for
            the development of aggression circuitry in male mice
  JOURNAL   Curr Biol 35 (11), 2684-2696 (2025)
   PUBMED   40403719
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Terakawa,J., Nakamura,S., Ohtomo,M., Uehara,S., Kawata,Y.,
            Takarabe,S., Sugita,H., Namiki,T., Kageyama,A., Noguchi,M.,
            Murakami,H., Kashiwazaki,N. and Ito,J.
  TITLE     LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo
            Implantation in Mice
  JOURNAL   Biomolecules 15 (5), 698 (2025)
   PUBMED   40427591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 599)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 599)
  AUTHORS   Wu,T.C., Wang,L. and Wan,Y.J.
  TITLE     Expression of estrogen receptor gene in mouse oocyte and during
            embryogenesis
  JOURNAL   Mol Reprod Dev 33 (4), 407-412 (1992)
   PUBMED   1472372
REFERENCE   7  (residues 1 to 599)
  AUTHORS   Greco,T.L., Furlow,J.D., Duello,T.M. and Gorski,J.
  TITLE     Immunodetection of estrogen receptors in fetal and neonatal female
            mouse reproductive tracts
  JOURNAL   Endocrinology 129 (3), 1326-1332 (1991)
   PUBMED   1874174
REFERENCE   8  (residues 1 to 599)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   9  (residues 1 to 599)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (residues 1 to 599)
  AUTHORS   White,R., Lees,J.A., Needham,M., Ham,J. and Parker,M.
  TITLE     Structural organization and expression of the mouse estrogen
            receptor
  JOURNAL   Mol Endocrinol 1 (10), 735-744 (1987)
   PUBMED   2484714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158617.9, AC153573.3 and
            AC156393.12.
            
            On or before May 4, 2006 this sequence version replaced
            XP_990728.1, XP_990766.1, XP_990798.1.
            
            Summary: This gene encodes an estrogen receptor, a member of the
            nuclear hormone family of intracellular receptors. The encoded
            protein, activated by the sex hormone estrogen, is a transcription
            factor composed of several domains important for hormone binding,
            DNA binding, and activation of transcription. Estrogen and its
            receptors are essential for sexual development and reproductive
            function, but also play a role in other tissues such as bone.
            Similar genes in human have been implicated in pathological
            processes including breast cancer, endometrial cancer, and
            osteoporosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 2, 3, and 6 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036627.1, SRR10223971.10092.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.03 cM"
     Protein         1..599
                     /product="estrogen receptor isoform 1"
                     /note="estradiol receptor; nuclear receptor subfamily 3
                     group A member 1; C-terminally-truncated estrogen receptor
                     alpha product-5; C-terminally-truncated estrogen receptor
                     alpha product-6; C-terminally-truncated estrogen receptor
                     alpha product-7; C-terminally-truncated estrogen receptor
                     alpha product-4"
                     /calculated_mol_wt=66824
     Region          1..188
                     /region_name="Modulating (transactivation AF-1), mediates
                     interaction with MACROD1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            10
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..178
                     /region_name="Interaction with DDX5, self-association.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..47
                     /region_name="Required for interaction with NCOA1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          42..185
                     /region_name="Oest_recep"
                     /note="Oestrogen receptor; pfam02159"
                     /db_xref="CDD:460469"
     Site            50
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          147..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          184..265
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Region          189..314
                     /region_name="Mediates interaction with DNTTIP2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(189,192,206,209,225,231,241,244)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(198..201,207..208,210..212,214..215,238..239,242,
                     245)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(224..227,231..232,237,240)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          255..314
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            264
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          266..599
                     /region_name="Interaction with AKAP13.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          268..599
                     /region_name="Self-association. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          314..551
                     /region_name="NR_LBD_ER"
                     /note="Ligand binding domain of Estrogen receptor, which
                     are activated by the hormone 17beta-estradiol (estrogen);
                     cd06949"
                     /db_xref="CDD:132747"
     Region          315..599
                     /region_name="Transactivation AF-2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(350,355,357,391,398,525,528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132747"
     Site            order(362,366,379..380,384,542,546..547)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            order(455,459,461..462,483,487..488,491,505..506,508..510,
                     512..513,516..517,519..520,523)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            541
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          556..599
                     /region_name="ESR1_C"
                     /note="Oestrogen-type nuclear receptor final C-terminal;
                     pfam12743"
                     /db_xref="CDD:432757"
     Region          557..581
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            575
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831,
                     ECO:0000269|PubMed:8999954. /id=CAR_000137; propagated
                     from UniProtKB/Swiss-Prot (P19785.1)"
     CDS             1..599
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /coded_by="NM_007956.6:223..2022"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS56678.1"
                     /db_xref="GeneID:13982"
                     /db_xref="MGI:MGI:1352467"
ORIGIN      
        1 mtmtlhtkas gmallhqiqg neleplnrpq lkmpmeralg evyvdnskpt vfnypegaay
       61 efnaaaaaaa aasapvygqs giaygpgsea aafsanslga fpqlnsvsps plmllhpppq
      121 lspflhphgq qvpyylenep sayavrdtgp pafyrsnsdn rrqngrerls ssnekgnmim
      181 esaketryca vcndyasgyh ygvwscegck affkrsiqgh ndymcpatnq ctidknrrks
      241 cqacrlrkcy evgmmkggir kdrrggrmlk hkrqrddleg rnemgasgdm raanlwpspl
      301 vikhtkknsp alsltadqmv salldaeppm iyseydpsrp fseasmmgll tnladrelvh
      361 minwakrvpg fgdlnlhdqv hllecawlei lmiglvwrsm ehpgkllfap nllldrnqgk
      421 cvegmveifd mllatssrfr mmnlqgeefv clksiillns gvytflsstl ksleekdhih
      481 rvldkitdtl ihlmakaglt lqqqhrrlaq lllilshirh msnkgmehly nmkcknvvpl
      541 ydlllemlda hrlhapasrm gvppeepsqt qlattsstsa hslqtyyipp eaegfpnti
//
LOCUS       NP_001103737             113 aa            linear   ROD 27-AUG-2025
DEFINITION  vascular endothelial growth factor A, long form isoform 5 precursor
            [Mus musculus].
ACCESSION   NP_001103737
VERSION     NP_001103737.1
DBSOURCE    REFSEQ: accession NM_001110267.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 113)
  AUTHORS   Man,X., Usui,N., Doi,M. and Shimada,S.
  TITLE     Sex differences in placental structure and gene expression in ICR
            mice during embryonic development
  JOURNAL   Sci Rep 15 (1), 24067 (2025)
   PUBMED   40617958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 113)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   3  (residues 1 to 113)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 113)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (residues 1 to 113)
  AUTHORS   Bastide,A., Karaa,Z., Bornes,S., Hieblot,C., Lacazette,E., Prats,H.
            and Touriol,C.
  TITLE     An upstream open reading frame within an IRES controls expression
            of a specific VEGF-A isoform
  JOURNAL   Nucleic Acids Res 36 (7), 2434-2445 (2008)
   PUBMED   18304943
REFERENCE   6  (residues 1 to 113)
  AUTHORS   Huez,I., Bornes,S., Bresson,D., Creancier,L. and Prats,H.
  TITLE     New vascular endothelial growth factor isoform generated by
            internal ribosome entry site-driven CUG translation initiation
  JOURNAL   Mol Endocrinol 15 (12), 2197-2210 (2001)
   PUBMED   11731620
REFERENCE   7  (residues 1 to 113)
  AUTHORS   Tee,M.K. and Jaffe,R.B.
  TITLE     A precursor form of vascular endothelial growth factor arises by
            initiation from an upstream in-frame CUG codon
  JOURNAL   Biochem J 359 (Pt 1), 219-226 (2001)
   PUBMED   11563986
REFERENCE   8  (residues 1 to 113)
  AUTHORS   Meiron,M., Anunu,R., Scheinman,E.J., Hashmueli,S. and Levi,B.Z.
  TITLE     New isoforms of VEGF are translated from alternative initiation CUG
            codons located in its 5'UTR
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1053-1060 (2001)
   PUBMED   11352659
REFERENCE   9  (residues 1 to 113)
  AUTHORS   Claffey,K.P., Wilkison,W.O. and Spiegelman,B.M.
  TITLE     Vascular endothelial growth factor. Regulation by cell
            differentiation and activated second messenger pathways
  JOURNAL   J Biol Chem 267 (23), 16317-16322 (1992)
   PUBMED   1644816
REFERENCE   10 (residues 1 to 113)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU920197.1, AC127690.4,
            BQ554097.1, BC061468.1 and AK031905.1.
            
            Summary: This gene is a member of the PDGF/VEGF growth factor
            family. It encodes a heparin-binding protein, which exists as a
            disulfide-linked homodimer. This growth factor induces
            proliferation and migration of vascular endothelial cells, and is
            essential for both physiological and pathological angiogenesis.
            Disruption of this gene in mice resulted in abnormal embryonic
            blood vessel formation. This gene is upregulated in many known
            tumors and its expression is correlated with tumor stage and
            progression. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. There is also
            evidence for alternative translation initiation from upstream
            non-AUG (CUG) codons resulting in additional isoforms. A recent
            study showed that a C-terminally extended isoform is produced by
            use of an alternative in-frame translation termination codon via a
            stop codon readthrough mechanism, and that this isoform is
            antiangiogenic. Expression of some isoforms derived from the AUG
            start codon is regulated by a small upstream open reading frame,
            which is located within an internal ribosome entry site.[provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (5) differs in the 5' UTR and 5'
            coding region and also lacks an in-frame, internal coding exon,
            compared to variant 1. The resulting isoform (5) has a distinct and
            shorter N-terminus and also lacks an internal segment, compared to
            isoform 1. This variant has transcript support, but the protein is
            predicted.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ959864.1, CX234175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..113
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.79 cM"
     Protein         1..113
                     /product="vascular endothelial growth factor A, long form
                     isoform 5 precursor"
                     /note="vascular permeability factor; vascular endothelial
                     growth factor A, long form"
                     /calculated_mol_wt=12831
     mat_peptide     23..113
                     /product="vascular endothelial growth factor A, long form
                     isoform 5"
                     /calculated_mol_wt=10863
     Region          <27..54
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family domain; PDGF is a potent
                     activator for cells of mesenchymal origin; PDGF-A and
                     PDGF-B form AA and BB homodimers and an AB heterodimer;
                     VEGF is a potent mitogen in embryonic and...; cl00116"
                     /db_xref="CDD:444701"
     Region          65..113
                     /region_name="VEGF_C"
                     /note="VEGF heparin-binding domain; pfam14554"
                     /db_xref="CDD:405273"
     CDS             1..113
                     /gene="Vegfa"
                     /gene_synonym="L-VEGF; Vegf; Vpf"
                     /coded_by="NM_001110267.1:563..904"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5"
                     /db_xref="GeneID:22339"
                     /db_xref="MGI:MGI:103178"
ORIGIN      
        1 magapgcpig vwlagslttv icslplqimr ikphqsqhig emsflqhsrc ecrpkkdrtk
       61 penhcepcse rrkhlfvqdp qtckcscknt dsrckarqle lnertcrcdk prr
//
LOCUS       NP_032840                284 aa            linear   ROD 27-AUG-2025
DEFINITION  pancreas/duodenum homeobox protein 1 [Mus musculus].
ACCESSION   NP_032840
VERSION     NP_032840.1
DBSOURCE    REFSEQ: accession NM_008814.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 284)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   2  (residues 1 to 284)
  AUTHORS   Ahuja,N., Maynard,C., Bierschenck,T. and Cleaver,O.
  TITLE     Characterization of Hippo signaling components in the early dorsal
            pancreatic bud
  JOURNAL   Gene Expr Patterns 55, 119392 (2025)
   PUBMED   40081783
REFERENCE   3  (residues 1 to 284)
  AUTHORS   Onate,M.K., Oon,C., Bhattacharyya,S., Low,V., Chen,C., Zhao,X.,
            Arnold,F., Yan,Z., Pramod,S., Hang,Y., Ho,Y.J., Lowe,S.W.,
            Kim,S.K., Xia,Z. and Sherman,M.H.
  TITLE     Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and
            Restrains Tumor Progression
  JOURNAL   Cancer Discov 15 (5), 913-929 (2025)
   PUBMED   39918337
REFERENCE   4  (residues 1 to 284)
  AUTHORS   Breunig,M., Hohwieler,M., Haderspeck,J., von Zweydorf,F., Hauff,N.,
            Pasquini,L.P., Wiegreffe,C., Zimmer,E., Mulaw,M.A., Julier,C.,
            Simon,E., Gloeckner,C.J., Liebau,S. and Kleger,A.
  TITLE     PPDPF is not a key regulator of human pancreas development
  JOURNAL   PLoS Genet 21 (4), e1011657 (2025)
   PUBMED   40193385
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 284)
  AUTHORS   Li,K.R., Yu,P.L., Zheng,Q.Q., Wang,X., Fang,X., Li,L.C. and Xu,C.R.
  TITLE     Spatiotemporal and genetic cell lineage tracing of endodermal
            organogenesis at single-cell resolution
  JOURNAL   Cell 188 (3), 796-813 (2025)
   PUBMED   39824184
REFERENCE   6  (residues 1 to 284)
  AUTHORS   Fiedorek,F.T. Jr. and Kay,E.S.
  TITLE     Mapping of the insulin promoter factor 1 gene (Ipf1) to distal
            mouse chromosome 5
  JOURNAL   Genomics 28 (3), 581-584 (1995)
   PUBMED   7490099
REFERENCE   7  (residues 1 to 284)
  AUTHORS   Guz,Y., Montminy,M.R., Stein,R., Leonard,J., Gamer,L.W.,
            Wright,C.V. and Teitelman,G.
  TITLE     Expression of murine STF-1, a putative insulin gene transcription
            factor, in beta cells of pancreas, duodenal epithelium and
            pancreatic exocrine and endocrine progenitors during ontogeny
  JOURNAL   Development 121 (1), 11-18 (1995)
   PUBMED   7867492
REFERENCE   8  (residues 1 to 284)
  AUTHORS   Jonsson,J., Carlsson,L., Edlund,T. and Edlund,H.
  TITLE     Insulin-promoter-factor 1 is required for pancreas development in
            mice
  JOURNAL   Nature 371 (6498), 606-609 (1994)
   PUBMED   7935793
REFERENCE   9  (residues 1 to 284)
  AUTHORS   Ohlsson,H., Karlsson,K. and Edlund,T.
  TITLE     IPF1, a homeodomain-containing transactivator of the insulin gene
  JOURNAL   EMBO J 12 (11), 4251-4259 (1993)
   PUBMED   7901001
REFERENCE   10 (residues 1 to 284)
  AUTHORS   Leonard,J., Peers,B., Johnson,T., Ferreri,K., Lee,S. and
            Montminy,M.R.
  TITLE     Characterization of somatostatin transactivating factor-1, a novel
            homeobox factor that stimulates somatostatin expression in
            pancreatic islet cells
  JOURNAL   Mol Endocrinol 7 (10), 1275-1283 (1993)
   PUBMED   7505393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127549.3, BC105642.1, AK020261.1 and BP771579.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020261.1, BC105642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.84 cM"
     Protein         1..284
                     /product="pancreas/duodenum homeobox protein 1"
                     /note="insulin promoter factor 1, homeodomain
                     transcription factor; islet/duodenum homeobox 1;
                     somatostatin-transactivating factor 1; pancreatic and
                     duodenal homeobox gene 1"
                     /calculated_mol_wt=30868
     Region          13..73
                     /region_name="Transactivation domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P52946.1)"
     Region          30..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52946.1)"
     Region          119..124
                     /region_name="Antp-type hexapeptide"
                     /note="propagated from UniProtKB/Swiss-Prot (P52946.1)"
     Region          148..204
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PASK.
                     /evidence=ECO:0000269|PubMed:17052199; propagated from
                     UniProtKB/Swiss-Prot (P52946.1)"
     Region          198..204
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (P52946.1)"
     Region          202..284
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52946.1)"
     Site            269
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by HIPK2.
                     /evidence=ECO:0000269|PubMed:20637728; propagated from
                     UniProtKB/Swiss-Prot (P52946.1)"
     CDS             1..284
                     /gene="Pdx1"
                     /gene_synonym="IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1"
                     /coded_by="NM_008814.4:143..997"
                     /db_xref="CCDS:CCDS39398.1"
                     /db_xref="GeneID:18609"
                     /db_xref="MGI:MGI:102851"
ORIGIN      
        1 mnseeqyyaa tqlykdpcaf qrgpvpefsa nppaclymgr qpppppppqf tsslgsleqg
       61 sppdispyev pplasddpag ahlhhhlpaq lglahpppgp fpngtepggl eepnrvqlpf
      121 pwmkstkaha wkgqwaggay taepeenkrt rtaytraqll elekeflfnk yisrprrvel
      181 avmlnlterh ikiwfqnrrm kwkkeedkkr ssgtpsgggg geepeqdcav tsgeellavp
      241 plpppggavp pgvpaavreg llpsglsvsp qpssiaplrp qepr
//
LOCUS       NP_032726                318 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein Nkx-2.5 [Mus musculus].
ACCESSION   NP_032726
VERSION     NP_032726.1
DBSOURCE    REFSEQ: accession NM_008700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 318)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 318)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   3  (residues 1 to 318)
  AUTHORS   Lin,S., Dieterich,C., Britto-Borges,T., Gunther,S., Kreher,S.,
            Eibach,Y., Kuenne,C., Schneider,A. and Braun,T.
  TITLE     Rbpms2 prevents major cardiac defects in cardiomyocyte-specific
            Rbpms-deficient mice
  JOURNAL   Dev Cell (2025) In press
   PUBMED   40602408
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 318)
  AUTHORS   Wen,H., Chandrasekaran,P., Jin,A., Pankin,J., Lu,M., Liberti,D.C.,
            Zepp,J.A., Jain,R., Morrisey,E.E., Michki,S.N. and Frank,D.B.
  TITLE     A spatiotemporal cell atlas of cardiopulmonary progenitor cell
            allocation during development
  JOURNAL   Cell Rep 44 (4), 115513 (2025)
   PUBMED   40178979
REFERENCE   5  (residues 1 to 318)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 318)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   7  (residues 1 to 318)
  AUTHORS   Chen,C.Y. and Schwartz,R.J.
  TITLE     Identification of novel DNA binding targets and regulatory domains
            of a murine tinman homeodomain factor, nkx-2.5
  JOURNAL   J Biol Chem 270 (26), 15628-15633 (1995)
   PUBMED   7797561
REFERENCE   8  (residues 1 to 318)
  AUTHORS   Himmelbauer,H., Harvey,R.P., Copeland,N.G., Jenkins,N.A. and
            Silver,L.M.
  TITLE     High-resolution genetic analysis of a deletion on mouse chromosome
            17 extending over the fused, tufted, and homeobox Nkx2-5 loci
  JOURNAL   Mamm Genome 5 (12), 814-816 (1994)
   PUBMED   7894168
REFERENCE   9  (residues 1 to 318)
  AUTHORS   Lints,T.J., Parsons,L.M., Hartley,L., Lyons,I. and Harvey,R.P.
  TITLE     Nkx-2.5: a novel murine homeobox gene expressed in early heart
            progenitor cells and their myogenic descendants
  JOURNAL   Development 119 (2), 419-431 (1993)
   PUBMED   7904557
  REMARK    Erratum:[Development. 1993 Nov;119(3):969. doi:
            10.1242/dev.119.3.969. PMID: 7910553]
REFERENCE   10 (residues 1 to 318)
  AUTHORS   Komuro,I. and Izumo,S.
  TITLE     Csx: a murine homeobox-containing gene specifically expressed in
            the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 8145-8149 (1993)
   PUBMED   7690144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144621.3 and AK142146.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142146.1, X75415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.6 cM"
     Protein         1..318
                     /product="homeobox protein Nkx-2.5"
                     /note="homeobox protein CSX; cardiac-specific homeobox;
                     homeobox protein NK-2 homolog E; Drosophila NK2
                     transcription factor related, locus 5"
                     /calculated_mol_wt=34032
     Region          144..194
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..318
                     /gene="Nkx2-5"
                     /gene_synonym="Csx; Nkx-2.5; Nkx2.5; tinman"
                     /coded_by="NM_008700.2:211..1167"
                     /db_xref="CCDS:CCDS28556.1"
                     /db_xref="GeneID:18091"
                     /db_xref="MGI:MGI:97350"
ORIGIN      
        1 mfpspaltpt pfsvkdilnl eqqqrslasg dlsarleatl apascmlaaf kpeaysgpea
       61 aasglaelra emgpapsppk cspafpaapt fypgaygdpd pakdpradkk elcalqkave
      121 ldkaetdgae rprarrrrkp rvlfsqaqvy elerrfkqqr ylsaperdql asvlkltstq
      181 vkiwfqnrry kckrqrqdqt lellgppppp arriavpvlv rdgkpclgdp aayapaygvg
      241 lnaygynayp ypsyggaacs pgyscaaypa appaaqppaa sansnfvnfg vgdlntvqsp
      301 gmpqgnsgvs tlhgiraw
//
LOCUS       NP_001351550             715 aa            linear   ROD 27-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform 4 [Mus musculus].
ACCESSION   NP_001351550 XP_006515485
VERSION     NP_001351550.1
DBSOURCE    REFSEQ: accession NM_001364621.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 715)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 715)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 715)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   4  (residues 1 to 715)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   5  (residues 1 to 715)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 715)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (residues 1 to 715)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 715)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (residues 1 to 715)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (residues 1 to 715)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6.
            
            On Jun 26, 2018 this sequence version replaced XP_006515485.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB794093.1, AF463504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     Protein         1..715
                     /product="metastasis-associated protein MTA1 isoform 4"
                     /note="metastasis-associated protein MTA1"
                     /calculated_mol_wt=80667
     Region          3..188
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          167..219
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          287..332
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(288,318..319,321..322,324..326,328..330)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Site            386
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          388..441
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          437..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            449
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          464..541
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13330; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          542..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          545..552
                     /region_name="SH3-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            564
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            576
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13330; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            626
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q13330; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Site            639
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13330; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          656..686
                     /region_name="Interaction with RBBP4.
                     /evidence=ECO:0000250|UniProtKB:Q13330"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          673..715
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          696..705
                     /region_name="SH3-binding. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     Region          711..715
                     /region_name="SUMO interaction motif 1 (SIM), crucial for
                     efficient sumoylation. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B0.1)"
     CDS             1..715
                     /gene="Mta1"
                     /coded_by="NM_001364621.1:141..2288"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd issslialad
       61 khatlsvcyr agpgadtgee geveeevenp emvdlpeklk hqlrhrelfl srqleslpat
      121 hirgkcsvtl lneteslksy leredfffys lvydpqqktl ladkgeirvg nryqaditdl
      181 lkegeedgrd qskletkvwe ahnplvdkqi dqflvvarsv gtfaraldcs ssvrqpslhm
      241 saaaasrdit lfhamdtlhk niydiskais alvpqggpvl crdemeewsa seanlfeeal
      301 ekygkdftdi qqdflpwksl tsiieyyymw kttdryvqqk rlkaaeaesk lkqvyipnyn
      361 kpnpnqisas svkatvvngt gtpgqspgag racescyttq syqwyswgpp nmqcrlcasc
      421 wtywkkyggl kmptrldger pgpnrnnmsp hgiparssgs pkfamktrqa fylhttkltr
      481 iarrlcreil rpwhaarhpy mpinsaaika ectarlpeas qsplvlkqvv rkpleavlry
      541 lethprppkp dpvkssssvl ssltpaksap vinngsptil gkrsyeqhng vdgnmkkrll
      601 mpsrglanhg qtrhmgpsrn lllngksypt kvrlirggsl ppvkrrrmnw idapddvfym
      661 ateetrkirk llsssetkra arrpykpial rqsqalplrp pppapvndep ivied
//
LOCUS       NP_001390174             122 aa            linear   ROD 27-AUG-2025
DEFINITION  GTPase KRas isoform 3 [Mus musculus].
ACCESSION   NP_001390174
VERSION     NP_001390174.1
DBSOURCE    REFSEQ: accession NM_001403245.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 122)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 122)
  AUTHORS   Quijano,E., Martinez-Saucedo,D., Ianniello,Z., Pinto-Medici,N.,
            Rackear,M., Chen,H., Lola-Pereira,L., Liu,Y., Hegan,D., Shan,X.,
            Tseng,R., Yugawa,D., Chowdhury,S., Khang,M., Singh,J.P.,
            Abdullah,R., Azhir,P., Kashima,S., Woods,W.S., Gosstola,N.,
            Turner,B.C., Squinto,S., Ludwig,D.L., Bindra,R.S., Robert,M.E.,
            Braun,D.A., Perez Pinera,P., Saltzman,W.M., Escobar-Hoyos,L.F. and
            Glazer,P.M.
  TITLE     Systemic administration of an RNA binding and cell-penetrating
            antibody targets therapeutic RNA to multiple mouse models of cancer
  JOURNAL   Sci Transl Med 17 (807), eadk1868 (2025)
   PUBMED   40668891
REFERENCE   3  (residues 1 to 122)
  AUTHORS   Suzuki,Y., Sugimori,M., Kanemaru,Y., Onodera,S., Tsuchiya,H.,
            Ikeda,A., Ikeda,R., Goda,Y., Kaneko,H., Irie,K., Sue,S., Ijichi,H.
            and Maeda,S.
  TITLE     Development of a novel PIK3CA-mutated pancreatic tumor mouse model
            and evaluation of the therapeutic effects of a PI3K inhibitor
  JOURNAL   PLoS One 20 (7), e0326491 (2025)
   PUBMED   40638603
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 122)
  AUTHORS   Poirier,A., Tribouillard,L., Kordahi,M., Gelinas,Y., Roy,J.,
            Beaulieu,M.J., Orain,M., Blanchet,M.R., Joubert,P. and Laplante,M.
  TITLE     Generation and characterization of a Cre-inducible ZNF768
            overexpression mouse model
  JOURNAL   Sci Rep 15 (1), 19792 (2025)
   PUBMED   40473701
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 122)
  AUTHORS   Woo,S.M., Lee,H., Kang,J.H., Kang,M., Choi,W., Sim,S.H., Chun,J.W.,
            Han,N., Kim,K.H., Ham,W., Hong,W., Kim,C., Park,J.H., Han,D.,
            Yook,J.I., Lee,W.J. and Kim,S.Y.
  TITLE     Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the
            Tumor-Promoting Effects of a High-Fat Diet
  JOURNAL   Theranostics 15 (13), 6516-6533 (2025)
   PUBMED   40521210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 122)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (residues 1 to 122)
  AUTHORS   Lord,P.G., Hardaker,K.J., Loughlin,J.M., Marsden,A.M. and
            Orton,T.C.
  TITLE     Point mutation analysis of ras genes in spontaneous and chemically
            induced C57Bl/10J mouse liver tumours
  JOURNAL   Carcinogenesis 13 (8), 1383-1387 (1992)
   PUBMED   1499088
REFERENCE   8  (residues 1 to 122)
  AUTHORS   You,M., Wang,Y., Stoner,G., You,L., Maronpot,R., Reynolds,S.H. and
            Anderson,M.
  TITLE     Parental bias of Ki-ras oncogenes detected in lung tumors from
            mouse hybrids
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5804-5808 (1992)
   PUBMED   1352876
REFERENCE   9  (residues 1 to 122)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (residues 1 to 122)
  AUTHORS   Scolnick,E.M., Papageorge,A.G. and Shih,T.Y.
  TITLE     Guanine nucleotide-binding activity as an assay for src protein of
            rat-derived murine sarcoma viruses
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5355-5359 (1979)
   PUBMED   228288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157091.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.124169.1,
                                           SRR10662774.166190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     Protein         1..122
                     /product="GTPase KRas isoform 3"
                     /EC_number="3.6.5.2"
                     /note="Kirsten rat sarcoma oncogene 2, expressed; p21
                     protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene
                     homolog; GTPase KRas"
                     /calculated_mol_wt=14118
     Region          <1..98
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            50..53
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133338"
     Site            79..81
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133338"
     CDS             1..122
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /coded_by="NM_001403245.1:279..647"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
ORIGIN      
        1 mrdqymrtge gflcvfainn tksfedihhy reqikrvkds edvpmvlvgn kcdlpsrtvd
       61 tkqaqelars ygipfietsa ktrqgvddaf ytlvreirkh kekmskdgkk kkkksrtrct
      121 vm
//
LOCUS       NP_001398749             436 aa            linear   ROD 27-AUG-2025
DEFINITION  erythropoietin receptor isoform 2 [Mus musculus].
ACCESSION   NP_001398749 XP_017168619
VERSION     NP_001398749.1
DBSOURCE    REFSEQ: accession NM_001411820.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 436)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 436)
  AUTHORS   Abid,D., Murphy,K., Murphy,Z., Rahman,N., Getman,M. and Steiner,L.
  TITLE     The Condensin II complex regulates essential gene expression
            programs during erythropoiesis
  JOURNAL   Development 152 (10) (2025)
   PUBMED   40260585
REFERENCE   3  (residues 1 to 436)
  AUTHORS   Chiu,D.K., Zhang,X., Cheng,B.Y., Liu,Q., Hayashi,K., Yu,B., Lee,R.,
            Zhang,C., An,X., Rajadas,J., Reticker-Flynn,N.E., Rankin,E.B. and
            Engleman,E.G.
  TITLE     Tumor-derived erythropoietin acts as an immunosuppressive switch in
            cancer immunity
  JOURNAL   Science 388 (6745), eadr3026 (2025)
   PUBMED   40273234
REFERENCE   4  (residues 1 to 436)
  AUTHORS   Scherer,T., Metz,M., Beghini,M., Bilban,M., Gensthaler,L.,
            Luca,A.C., Kaplanian,M., Abu Eid,S., Koldyka,O., Hackl,M.T.,
            Durr,S., Rivelles,E., Schonecker,S.S., Poltl,L., Kaya,A., Chami,R.,
            Nusko,L., Tschare,C., Ablaza,K., Hobler,A.L., Klimek,P.,
            Leutner,M., Yamamoto,M., Suzuki,N., Stemmer,K., Zeyda,M.,
            Steinacher,D., Nics,L., Muller,A.M.S., Helbich,T.H., Moriggl,R.,
            Kautzky-Willer,A., Windberger,U., Prager,G. and Furnsinn,C.
  TITLE     A direct effect of the hematocrit on blood glucose: Evidence from
            hypoxia- and erythropoietin-treated mice
  JOURNAL   Sci Adv 11 (16), eadt7366 (2025)
   PUBMED   40238885
REFERENCE   5  (residues 1 to 436)
  AUTHORS   Lyu,J., Gu,Z., Zhang,Y., Vu,H.S., Lechauve,C., Cai,F., Cao,H.,
            Keith,J., Brancaleoni,V., Granata,F., Motta,I., Cappellini,M.D.,
            Huang,L.J., DeBerardinis,R.J., Weiss,M.J., Ni,M. and Xu,J.
  TITLE     A glutamine metabolic switch supports erythropoiesis
  JOURNAL   Science 386 (6723), eadh9215 (2024)
   PUBMED   39541460
REFERENCE   6  (residues 1 to 436)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (residues 1 to 436)
  AUTHORS   Heberlein,C., Fischer,K.D., Stoffel,M., Nowock,J., Ford,A.,
            Tessmer,U. and Stocking,C.
  TITLE     The gene for erythropoietin receptor is expressed in multipotential
            hematopoietic and embryonal stem cells: evidence for
            differentiation stage-specific regulation
  JOURNAL   Mol Cell Biol 12 (4), 1815-1826 (1992)
   PUBMED   1312671
REFERENCE   8  (residues 1 to 436)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   9  (residues 1 to 436)
  AUTHORS   Longmore,G.D., Pharr,P. and Lodish,H.F.
  TITLE     Mutation in murine erythropoietin receptor induces
            erythropoietin-independent erythroid proliferation in vitro,
            polycythemia in vivo
  JOURNAL   Leukemia 6 Suppl 3, 130S-134S (1992)
   PUBMED   1318465
REFERENCE   10 (residues 1 to 436)
  AUTHORS   Hino,M., Tojo,A., Misawa,Y., Morii,H., Takaku,F. and Shibuya,M.
  TITLE     Unregulated expression of the erythropoietin receptor gene caused
            by insertion of spleen focus-forming virus long terminal repeat in
            a murine erythroleukemia cell line
  JOURNAL   Mol Cell Biol 11 (11), 5527-5533 (1991)
   PUBMED   1656233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163623.5.
            
            On Sep 6, 2022 this sequence version replaced XP_017168619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010968.1, SRR13422601.826414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.93 cM"
     Protein         1..436
                     /product="erythropoietin receptor isoform 2"
                     /note="EPO-R"
                     /calculated_mol_wt=47338
     Region          <4..68
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     Region          88..172
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(161..162,164..165)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..436
                     /gene="Epor"
                     /coded_by="NM_001411820.1:155..1465"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:13857"
                     /db_xref="MGI:MGI:95408"
ORIGIN      
        1 mdfnysfsyq legesrkscs lhqaptvrgs vrfwcslpta dtssfvplel qvteasgspr
       61 yhriihinev vlldapagll arraeegshv vlrwlpppga pmtthiryev dvsagnragg
      121 tqrvevlegr tecvlsnlrg gtrytfavra rmaepsfsgf wsawsepasl ltasdldpli
      181 ltlslilvli sllltvlall shrrtlqqki wpgipspese feglftthkg nfqlwllqrd
      241 gclwwspgss fpedppahle vlseprwavt qagdpgadde gpllepvgse haqdtylvld
      301 kwllprtpcs enlsgpggsv dpvtmdease tsscpsdlas kprpegtsps sfeytildps
      361 sqllcpralp pelpptpphl kylylvvsds gistdyssgg sqgvhgdssd gpyshpyens
      421 lvpdseplhp gyvacs
//
LOCUS       NP_033846                349 aa            linear   ROD 27-AUG-2025
DEFINITION  cyclic AMP-dependent transcription factor ATF-4 [Mus musculus].
ACCESSION   NP_033846
VERSION     NP_033846.2
DBSOURCE    REFSEQ: accession NM_009716.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Wang,K., Farrell,A., Zhou,E., Qin,H., Zeng,Z., Zhou,K., Cunha E
            Rocha,K., Zhang,D., Wang,G., Atakilit,A., Sheppard,D., Lu,L.F.,
            Jin,C. and Ying,W.
  TITLE     ATF4 drives regulatory T cell functional specification in
            homeostasis and obesity
  JOURNAL   Sci Immunol 10 (105), eadp7193 (2025)
   PUBMED   40085690
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Zhu,S., Huo,S., He,W., Huang,C., Zhang,J., Jiang,X., Qian,Y.,
            Chen,C., Dai,Z.M., Yang,X., Qiu,M., Li,T. and Zhu,X.J.
  TITLE     Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the
            mouse craniofacial development
  JOURNAL   iScience 28 (3), 111972 (2025)
   PUBMED   40071146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 349)
  AUTHORS   Yang,L.X., Qi,C., Lu,S., Ye,X.S., Merikhian,P., Zhang,D.Y., Yao,T.,
            Zhao,J.S., Wu,Y., Jia,Y., Shan,B., Chen,J., Mou,X., You,J., Li,W.
            and Feng,Y.X.
  TITLE     Alleviation of liver fibrosis by inhibiting a non-canonical
            ATF4-regulated enhancer program in hepatic stellate cells
  JOURNAL   Nat Commun 16 (1), 524 (2025)
   PUBMED   39789010
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 349)
  AUTHORS   Vattem,K.M. and Wek,R.C.
  TITLE     Reinitiation involving upstream ORFs regulates ATF4 mRNA
            translation in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (31), 11269-11274 (2004)
   PUBMED   15277680
  REMARK    GeneRIF: delayed reinitiation allows for ribosomes to scan through
            the inhibitory uORF2 and instead reinitiate at the ATF4-coding
            region.
REFERENCE   7  (residues 1 to 349)
  AUTHORS   Lee,F.S., Lane,T.F., Kuo,A., Shackleford,G.M. and Leder,P.
  TITLE     Insertional mutagenesis identifies a member of the Wnt gene family
            as a candidate oncogene in the mammary epithelium of int-2/Fgf-3
            transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2268-2272 (1995)
   PUBMED   7892260
REFERENCE   8  (residues 1 to 349)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (residues 1 to 349)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   10 (residues 1 to 349)
  AUTHORS   Mielnicki,L.M. and Pruitt,S.C.
  TITLE     Isolation and nucleotide sequence of a murine cDNA homologous to
            human activating transcription factor 4
  JOURNAL   Nucleic Acids Res 19 (22), 6332 (1991)
   PUBMED   1956797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003001.1, BC085169.1 and BE992821.1.
            
            On Jan 12, 2007 this sequence version replaced NP_033846.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003001.1, BC085169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 15277680
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     Protein         1..349
                     /product="cyclic AMP-dependent transcription factor ATF-4"
                     /note="taxREB67 homolog; c/EBP-related ATF; cAMP-dependent
                     transcription factor ATF-4; tax-responsive enhancer
                     element-binding protein 67 homolog; cAMP-responsive
                     element-binding protein 2; cyclic AMP-responsive
                     element-binding protein 2"
                     /calculated_mol_wt=38224
     Region          49..75
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            60
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000269|PubMed:24809345; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          204..271
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          214..223
                     /region_name="BetaTrCP degron motif.
                     /evidence=ECO:0000269|PubMed:23663782"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P18848; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            234
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            235
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000269|PubMed:24809345; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KA3.
                     /evidence=ECO:0000269|PubMed:15109498; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          277..339
                     /region_name="bZIP_ATF4"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-4 (ATF-4) and similar proteins: a
                     DNA-binding and dimerization domain; cd14692"
                     /db_xref="CDD:269840"
     Region          278..298
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Region          279..338
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269840"
     Region          279..298
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            order(282..283,285..287,289..294,296..298)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269840"
     Site            order(301,304,307..308,311..312,314..315,318..319,
                     321..322,325,328..329,332..333,335..336)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269840"
     Region          303..339
                     /region_name="Interaction with GABBR1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Region          304..332
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            309
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P18848; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     CDS             1..349
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /coded_by="NM_009716.3:595..1644"
                     /db_xref="CCDS:CCDS37145.1"
                     /db_xref="GeneID:11911"
                     /db_xref="MGI:MGI:88096"
ORIGIN      
        1 mtemsflnse vlagdlmspf dqsglgaees lgllddylev akhlkphgfs sdkagssewp
       61 amddglasas dtgkedafsg tdwmlekmdl kefdfdalfr mddletmpde llttlddtcd
      121 lfaplvqetn keppqtvnpi ghlpeslikv dqvapftflq pfpcspgvls stpehsfsle
      181 lgsevdiseg drkpdsaayi tlippcvkee dtpsdndsgi cmspesylgs pqhspstsra
      241 ppdnlpspgg srgsprpkpy dppgvsltak vktekldkkl kkmeqnktaa tryrqkkrae
      301 qealtgecke lekknealke kadslakeiq ylkdlieevr kargkkrvp
//
LOCUS       NP_001400283             661 aa            linear   ROD 27-AUG-2025
DEFINITION  short transient receptor potential channel 1 isoform 6 [Mus
            musculus].
ACCESSION   NP_001400283 XP_006511119
VERSION     NP_001400283.1
DBSOURCE    REFSEQ: accession NM_001413354.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 661)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 661)
  AUTHORS   Ray,S., McCall,J.L., Tian,J.B., Jeon,J., Douglas,A., Tyler,K.,
            Liu,S., Berry,K., Nicewarner,B., Hall,C., Groschner,K., Bacsa,B.,
            Geldenhuys,W., Zhu,M.X., Blair,H.C., Barnett,J.B. and Soboloff,J.
  TITLE     Targeting TRPC channels for control of arthritis-induced bone
            erosion
  JOURNAL   Sci Adv 11 (3), eabm9843 (2025)
   PUBMED   39813349
REFERENCE   3  (residues 1 to 661)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   4  (residues 1 to 661)
  AUTHORS   Atkins,R.M., Pantalia,M., Skaggs,C., Lau,A.K., Mahmood,M.B.,
            Anwar,M.M., Barron,L., Eby,B., Khan,U., Tsiokas,L. and Lau,K.
  TITLE     Normotensive metabolic syndrome in Transient Receptor Potential
            Canonical Channel type 1 Trpc1-/- mice
  JOURNAL   Biol Open 13 (7) (2024)
   PUBMED   38885005
  REMARK    GeneRIF: Normotensive metabolic syndrome in Transient Receptor
            Potential Canonical Channel type 1 Trpc1-/- mice.
REFERENCE   5  (residues 1 to 661)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 661)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
REFERENCE   7  (residues 1 to 661)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (residues 1 to 661)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (residues 1 to 661)
  AUTHORS   Sakura,H. and Ashcroft,F.M.
  TITLE     Identification of four trp1 gene variants murine pancreatic
            beta-cells
  JOURNAL   Diabetologia 40 (5), 528-532 (1997)
   PUBMED   9165220
REFERENCE   10 (residues 1 to 661)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC157947.2.
            
            On Oct 31, 2022 this sequence version replaced XP_006511119.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95169.1, SRR17784650.1385234.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.2 cM"
     Protein         1..661
                     /product="short transient receptor potential channel 1
                     isoform 6"
                     /note="short transient receptor potential channel 1;
                     trp-related protein 1; transient receptor protein 1"
                     /calculated_mol_wt=76993
     Region          25..642
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     CDS             1..661
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /coded_by="NM_001413354.1:649..2634"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
ORIGIN      
        1 mrsfscwrat rklmeriqnp eysttmdvap vilaahrnny eiltmllkqd vslpkphavg
       61 cectlcsakn kkdslrhsrf rldiyrclas palimlteed pilrafelsa dlkelslvev
      121 efrndyeela rqckmfakdl laqarnsrel evilnhtssd epldkrglle ermnlsrlkl
      181 aikynqkefv sqsncqqfln tvwfgqmsgy rrkptckkim tvltvgifwp vlslcyliap
      241 ksqfgriiht pfmkfiihga syftflllln lyslvynedk kntmgpaler idyllilwii
      301 gmiwsdikrl wyegledfle esrnqlsfvm nslylatfal kvvahnkfhd fadrkdwdaf
      361 hptlvaeglf afanvlsylr lffmyttssi lgplqismgq mlqdfgkflg mfllvlfsft
      421 igltqlydkg ytskeqkdcv gifceqqsnd tfhsfigtcf alfwyifsla hvaifvtrfs
      481 ygeelqsfvg avivgtynvv vvivltkllv amlhksfqli anhedkewkf araklwlsyf
      541 ddkctlpppf niipspktic ymisslskwi cshtskgkvk rqnslkewrn lkqkrdenyq
      601 kvmcclvhry ltsmrqkmqs tdqatvenln elrqdlskfr neirdllgfr tskyamfypr
      661 n
//
LOCUS       NP_034315                 86 aa            linear   ROD 27-AUG-2025
DEFINITION  high affinity immunoglobulin epsilon receptor subunit gamma
            precursor [Mus musculus].
ACCESSION   NP_034315
VERSION     NP_034315.1
DBSOURCE    REFSEQ: accession NM_010185.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 86)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   2  (residues 1 to 86)
  AUTHORS   Halfmann,P.J., Patel,R.S., Loeffler,K., Yasuhara,A., Van De
            Velde,L.A., Yang,J.E., Chervin,J., Troxell,C., Huang,M., Zheng,N.,
            Wright,E.R., Thomas,P.G., Wilson,P.C., Kawaoka,Y. and Kane,R.S.
  TITLE     Multivalent S2 subunit vaccines provide broad protection against
            Clade 1 sarbecoviruses in female mice
  JOURNAL   Nat Commun 16 (1), 462 (2025)
   PUBMED   39774966
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 86)
  AUTHORS   Case,J.B., Sanapala,S., Dillen,C., Rhodes,V., Zmasek,C.,
            Chicz,T.M., Switzer,C.E., Scheaffer,S.M., Georgiev,G.,
            Jacob-Dolan,C., Hauser,B.M., Dos Anjos,D.C.C., Adams,L.J.,
            Soudani,N., Liang,C.Y., Ying,B., McNamara,R.P., Scheuermann,R.H.,
            Boon,A.C.M., Fremont,D.H., Whelan,S.P.J., Schmidt,A.G., Sette,A.,
            Grifoni,A., Frieman,M.B. and Diamond,M.S.
  TITLE     A trivalent mucosal vaccine encoding phylogenetically inferred
            ancestral RBD sequences confers pan-Sarbecovirus protection in mice
  JOURNAL   Cell Host Microbe 32 (12), 2131-2147 (2024)
   PUBMED   39561781
REFERENCE   4  (residues 1 to 86)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 86)
  AUTHORS   Huang,C., Zhu,W., Li,Q., Lei,Y., Chen,X., Liu,S., Chen,D.,
            Zhong,L., Gao,F., Fu,S., He,D., Li,J. and Xu,H.
  TITLE     Antibody Fc-receptor FcepsilonR1gamma stabilizes cell surface
            receptors in group 3 innate lymphoid cells and promotes
            anti-infection immunity
  JOURNAL   Nat Commun 15 (1), 5981 (2024)
   PUBMED   39013884
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 86)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (residues 1 to 86)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (residues 1 to 86)
  AUTHORS   Hupp,K., Siwarski,D., Mock,B.A. and Kinet,J.P.
  TITLE     Gene mapping of the three subunits of the high affinity FcR for IgE
            to mouse chromosomes 1 and 19
  JOURNAL   J Immunol 143 (11), 3787-3791 (1989)
   PUBMED   2531187
REFERENCE   9  (residues 1 to 86)
  AUTHORS   Ra,C., Jouvin,M.H. and Kinet,J.P.
  TITLE     Complete structure of the mouse mast cell receptor for IgE (Fc
            epsilon RI) and surface expression of chimeric receptors
            (rat-mouse-human) on transfected cells
  JOURNAL   J Biol Chem 264 (26), 15323-15327 (1989)
   PUBMED   2527850
REFERENCE   10 (residues 1 to 86)
  AUTHORS   Hibbs,M.L., Walker,I.D., Kirszbaum,L., Pietersz,G.A., Deacon,N.J.,
            Chambers,G.W., McKenzie,I.F. and Hogarth,P.M.
  TITLE     The murine Fc receptor for immunoglobulin: purification, partial
            amino acid sequence, and isolation of cDNA clones
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6980-6984 (1986)
   PUBMED   2944118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY173505.1, BE634435.1 and CK791068.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034163.1, CB597667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..86
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.23 cM"
     Protein         1..86
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit gamma precursor"
                     /note="high affinity immunoglobulin epsilon receptor
                     subunit gamma; fceRI gamma; fc-epsilon RI-gamma; igE Fc
                     receptor subunit gamma; Fc receptor gamma-chain"
                     /calculated_mol_wt=7755
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P20491.1)"
                     /calculated_mol_wt=1915
     mat_peptide     19..86
                     /product="High affinity immunoglobulin epsilon receptor
                     subunit gamma. /id=PRO_0000016503"
                     /note="propagated from UniProtKB/Swiss-Prot (P20491.1)"
                     /calculated_mol_wt=7755
     Region          21..51
                     /region_name="TCR_zetazeta"
                     /note="T-cell surface glycoprotein CD3 zeta chain;
                     pfam11628"
                     /db_xref="CDD:463313"
     Site            24..44
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P20491.1)"
     Region          62..82
                     /region_name="ITAM"
                     /note="Immunoreceptor tyrosine-based activation motif;
                     smart00077"
                     /db_xref="CDD:128390"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660,
                     ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P20491.1)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660,
                     ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P20491.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (P20491.1)"
     CDS             1..86
                     /gene="Fcer1g"
                     /gene_synonym="CD23; Fce1g; FcepsilonRI; FcR-gamma;
                     FcRgamma; FcR[g]; Ly-50"
                     /coded_by="NM_010185.4:105..365"
                     /db_xref="CCDS:CCDS15483.1"
                     /db_xref="GeneID:14127"
                     /db_xref="MGI:MGI:95496"
ORIGIN      
        1 misavilfll llveqaaalg epqlcyilda vlflygivlt llycrlkiqv rkaaiasrek
       61 adavytglnt rsqetyetlk hekppq
//
LOCUS       NP_001390942             685 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4-like isoform 5 [Mus musculus].
ACCESSION   NP_001390942 XP_036017230
VERSION     NP_001390942.1
DBSOURCE    REFSEQ: accession NM_001404013.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 685)
  AUTHORS   Zeng,Q., Guo,H., Tang,N., Renavikar,P.S., Karandikar,N.J.,
            Lovett-Racke,A.E., Racke,M.K., Yan,C., Tang,R., Sinha,S., Ghosh,K.,
            Ryal,J.P., Ouyang,S., Chen,M., Amari,F., Vincenzo,C., Pope,R.M.,
            Li,Y., Yang,H., Langdon,W.Y. and Zhang,J.
  TITLE     K27-linked RORgammat ubiquitination by Nedd4 potentiates
            Th17-mediated autoimmunity
  JOURNAL   J Biomed Sci 32 (1), 26 (2025)
   PUBMED   39972304
  REMARK    Erratum:[J Biomed Sci. 2025 Apr 16;32(1):42. doi:
            10.1186/s12929-025-01136-8. PMID: 40234865]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 685)
  AUTHORS   Liu,H., Wang,N., Yang,R., Luan,J., Cao,M., Zhai,C., Wang,S.,
            Wei,M., Wang,D., Qiao,J., Liu,Y., She,W., Guo,N., Liao,B. and
            Gou,X.
  TITLE     E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis
            by Inhibiting IL-6/GP130 Signaling Pathway
  JOURNAL   J Invest Dermatol 144 (11), 2453-2464 (2024)
   PUBMED   38580105
  REMARK    GeneRIF: E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin
            Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
REFERENCE   3  (residues 1 to 685)
  AUTHORS   Blackburn,D.M., Sahinyan,K., Hernandez-Corchado,A., Lazure,F.,
            Richard,V., Raco,L., Perron,G., Zahedi,R.P., Borchers,C.H.,
            Lepper,C., Kawabe,H., Jahani-Asl,A., Najafabadi,H.S. and
            Soleimani,V.D.
  TITLE     The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell
            quiescence by inhibiting their activation
  JOURNAL   iScience 27 (7), 110241 (2024)
   PUBMED   39015146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 685)
  AUTHORS   Han,F., Wu,S., Dong,Y., Liu,Y., Sun,B. and Chen,L.
  TITLE     Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by
            downregulating CaMKKbeta in diabetic kidney disease
  JOURNAL   J Transl Med 22 (1), 465 (2024)
   PUBMED   38755664
  REMARK    GeneRIF: Aberrant expression of NEDD4L disrupts mitochondrial
            homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 685)
  AUTHORS   Flasza,M., Gorman,P., Roylance,R., Canfield,A.E. and Baron,M.
  TITLE     Alternative splicing determines the domain structure of WWP1, a
            Nedd4 family protein
  JOURNAL   Biochem Biophys Res Commun 290 (1), 431-437 (2002)
   PUBMED   11779188
REFERENCE   7  (residues 1 to 685)
  AUTHORS   Debonneville,C., Flores,S.Y., Kamynina,E., Plant,P.J., Tauxe,C.,
            Thomas,M.A., Munster,C., Chraibi,A., Pratt,J.H., Horisberger,J.D.,
            Pearce,D., Loffing,J. and Staub,O.
  TITLE     Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+)
            channel cell surface expression
  JOURNAL   EMBO J 20 (24), 7052-7059 (2001)
   PUBMED   11742982
REFERENCE   8  (residues 1 to 685)
  AUTHORS   Harvey,K.F., Dinudom,A., Cook,D.I. and Kumar,S.
  TITLE     The Nedd4-like protein KIAA0439 is a potential regulator of the
            epithelial sodium channel
  JOURNAL   J Biol Chem 276 (11), 8597-8601 (2001)
   PUBMED   11244092
REFERENCE   9  (residues 1 to 685)
  AUTHORS   Kamynina,E., Debonneville,C., Bens,M., Vandewalle,A. and Staub,O.
  TITLE     A novel mouse Nedd4 protein suppresses the activity of the
            epithelial Na+ channel
  JOURNAL   FASEB J 15 (1), 204-214 (2001)
   PUBMED   11149908
REFERENCE   10 (residues 1 to 685)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102333.10, AC161175.5 and AC102288.11.
            
            On Apr 7, 2022 this sequence version replaced XP_036017230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.219498.1,
                                           SRR17784643.26364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 37.57 cM"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase NEDD4-like isoform
                     5"
                     /EC_number="2.3.2.26"
                     /EC_number="2.3.2.36"
                     /note="E3 ubiquitin-protein ligase NEDD4-like; neural
                     precursor cell expressed, developmentally down-regulated
                     gene 4b; HECT-type E3 ubiquitin transferase NED4L"
                     /calculated_mol_wt=79573
     Region          <1..32
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          77..103
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          259..291
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(275,286)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(334,365,376,438,611,646..647,650..654,674,681)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          352..681
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(466,469..470,472..473,476,481,483,487..488,490,495,
                     500,517,521)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..685
                     /gene="Nedd4l"
                     /gene_synonym="1300012C07Rik; Nedd4-2; NEDD4.2; Nedd4b"
                     /coded_by="NM_001404013.1:425..2482"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:83814"
                     /db_xref="MGI:MGI:1933754"
ORIGIN      
        1 merpytfkdf llrprshksr vkgflrlkma ympknggqde enseqrddme hgwevvdsnd
       61 sasqhqeelp ppplppgwee kvdnlgrtyy vnhnnrstqw hrpslmdvss esdnnirqin
      121 qeaahrrfrs rrhisedlep easegggegp epwetiseem nmagdslsla lppppaspvs
      181 rtspqelsee vsrrlqitpd sngeqfssli qrepssrlrs csvtdtvaeq ahlppedprl
      241 kfpvhmrska slnpndlgpl ppgweerihl dgrtfyidhn skitqwedpr lqnpaitgpa
      301 vpysrefkqk ydyfrkklkk padipnrfem klhrnnifee syrrimsvkr pdvlkarlwi
      361 efesekgldy ggvarewffl lskemfnpyy glfeysatdn ytlqinpnsg lcnedhlsyf
      421 tfigrvagla vfhgklldgf firpfykmml gkqitlndme svdseyynsl kwilendpte
      481 ldlmfcidee nfgqtyqvdl kpngseimvt nenkreyidl viqwrfvnrv qkqmnafleg
      541 ftellpidli kifdenelel lmcglgdvdv ndwrqhsiyk ngycpnhpvi qwfwkavllm
      601 daekrirllq fvtgtsrvpm ngfaelygsn gpqlftieqw gspeklprah tcfnrldlpp
      661 yetfedlrek llmavenaqg fegvd
//
LOCUS       NP_001363947             533 aa            linear   ROD 27-AUG-2025
DEFINITION  calcitonin receptor isoform 1b precursor [Mus musculus].
ACCESSION   NP_001363947
VERSION     NP_001363947.1
DBSOURCE    REFSEQ: accession NM_001377018.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 533)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 533)
  AUTHORS   Zhu,W., Zhou,Z., Wu,C., Huang,Z., Zhao,R., Wang,X., Luo,L., Liu,Y.,
            Zhong,W., Zhao,Z., Ai,G., Zhong,J., Liu,S., Liu,W., Pang,X., Sun,Y.
            and Zeng,G.
  TITLE     miR-148b-5p regulates hypercalciuria and calcium-containing
            nephrolithiasis
  JOURNAL   Cell Mol Life Sci 81 (1), 369 (2024)
   PUBMED   39182194
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 533)
  AUTHORS   Kuriki,M., Korb,A., Comai,G. and Tajbakhsh,S.
  TITLE     Interplay between Pitx2 and Pax7 temporally governs specification
            of extraocular muscle stem cells
  JOURNAL   PLoS Genet 20 (6), e1010935 (2024)
   PUBMED   38875306
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 533)
  AUTHORS   Fukumitsu,K., Huang,A.J., McHugh,T.J. and Kuroda,K.O.
  TITLE     Role of Calcr expressing neurons in the medial amygdala in social
            contact among females
  JOURNAL   Mol Brain 16 (1), 10 (2023)
   PUBMED   36658598
  REMARK    GeneRIF: Role of Calcr expressing neurons in the medial amygdala in
            social contact among females.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 533)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
REFERENCE   7  (residues 1 to 533)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
REFERENCE   8  (residues 1 to 533)
  AUTHORS   Lee,S.K., Goldring,S.R. and Lorenzo,J.A.
  TITLE     Expression of the calcitonin receptor in bone marrow cell cultures
            and in bone: a specific marker of the differentiated osteoclast
            that is regulated by calcitonin
  JOURNAL   Endocrinology 136 (10), 4572-4581 (1995)
   PUBMED   7664679
REFERENCE   9  (residues 1 to 533)
  AUTHORS   Ikegame,M., Rakopoulos,M., Zhou,H., Houssami,S., Martin,T.J.,
            Moseley,J.M. and Findlay,D.M.
  TITLE     Calcitonin receptor isoforms in mouse and rat osteoclasts
  JOURNAL   J Bone Miner Res 10 (1), 59-65 (1995)
   PUBMED   7747631
REFERENCE   10 (residues 1 to 533)
  AUTHORS   Yamin,M., Gorn,A.H., Flannery,M.R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Tapp,D.R., Krane,S.M. and Goldring,S.R.
  TITLE     Cloning and characterization of a mouse brain calcitonin receptor
            complementary deoxyribonucleic acid and mapping of the calcitonin
            receptor gene
  JOURNAL   Endocrinology 135 (6), 2635-2643 (1994)
   PUBMED   7988453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161368.2 and AC066688.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2507984.1,
                                           SRR7652917.1130305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     Protein         1..533
                     /product="calcitonin receptor isoform 1b precursor"
                     /calculated_mol_wt=57528
     sig_peptide     1..41
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4959
     mat_peptide     42..533
                     /product="Calcitonin receptor. /id=PRO_0000012807"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
                     /calculated_mol_wt=57528
     Site            45
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60755.2)"
     Region          86..154
                     /region_name="HRM"
                     /note="Hormone receptor domain; pfam02793"
                     /db_xref="CDD:397086"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60755.2)"
     Site            142
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60755.2)"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60755.2)"
     Region          162..472
                     /region_name="7tmB1_calcitonin_R"
                     /note="calcitonin receptor, member of the class B family
                     of seven-transmembrane G protein-coupled receptors;
                     cd15274"
                     /db_xref="CDD:341343"
     Region          164..189
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341343"
     Site            164..186
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Site            order(169,173,215,218..219,222,274,281,351..352,354,356,
                     410,413,427,431)
                     /site_type="other"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]"
                     /db_xref="CDD:341343"
     Site            order(197,297..298,301..303,306..308,377,380..381,
                     384..385,399,402,448,458,462,469,472)
                     /site_type="other"
                     /note="G protein interaction site [polypeptide binding]"
                     /db_xref="CDD:341343"
     Region          198..220
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341343"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Region          274..301
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341343"
     Site            274..296
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Region          313..333
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341343"
     Site            314..334
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Region          348..377
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341343"
     Site            351..374
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Region          391..418
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341343"
     Site            395..413
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Site            422..448
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60755.2)"
     Region          424..449
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341343"
     CDS             1..533
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /coded_by="NM_001377018.1:306..1907"
                     /note="isoform 1b precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:12311"
                     /db_xref="MGI:MGI:101950"
ORIGIN      
        1 mtprrsrvkr rnlrkpkmrf llvnrftlll lllvsptpvl qaptnltdsg ldqepflylv
       61 grkklldaqy kcydrihqlp syegeglycn rtwdgwmcwd dtpagatayq hcpdyfpdfd
      121 taekvskycd engewfrhpd snrtwsnytl cnaftseklq nayvlyylal vghslsiaal
      181 vasmlifwif knlscqrvtl hkhmfltyil nsiiiiihlv evvpngdlvr rdpmhifhhn
      241 thmwtmqwel spplplsahe gkmdphasev isckvlhflh qymmscnyfw mlcegiylht
      301 livmavftde qrlrwyyllg wgfpivptii haitralyyn dncwlsaeth llyiihgpvm
      361 valvvnfffl lnivrvlvtk mrqtheaesy mylkavkatm vlvpllgiqf vvfpwrpsnk
      421 vlgkiydylm hslihfqgff vatiycfcnh evqvtlkrqw tqfkiqwsqr wgrrrrptnr
      481 vvsapravaf aepdglpiyi chqeprnppi snnegeeste mipmnviqqd asa
//
LOCUS       NP_035647                254 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptonemal complex protein 3 [Mus musculus].
ACCESSION   NP_035647
VERSION     NP_035647.2
DBSOURCE    REFSEQ: accession NM_011517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Zhao,B.W., Zhang,Y.N., Meng,T.G., Xu,Y.H., Lu,Y.K., Sun,S.M.,
            Guo,J.N., Yang,X.M. and Wang,Z.B.
  TITLE     Re-establishment of H3K9me2 eliminates the transcriptional
            inhibition of ST18 on meiotic genes and orchestrates female germ
            cell development
  JOURNAL   Nucleic Acids Res 53 (13) (2025)
   PUBMED   40650982
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   3  (residues 1 to 254)
  AUTHORS   Zhao,Z.H., Meng,T.G., Chen,X.Y., Gao,F., Schatten,H., Ou,X.H. and
            Sun,Q.Y.
  TITLE     Spatiotemporal and single-cell atlases to dissect regional specific
            cell types of the developing ovary
  JOURNAL   Commun Biol 8 (1), 849 (2025)
   PUBMED   40461746
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 254)
  AUTHORS   Yue,W.Y., Zhang,Y., Jiang,T.X. and Qiu,X.B.
  TITLE     Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors
            Rpn10 and Rpn13 in Germ Cell Formation and Fertility
  JOURNAL   Cells 14 (10), 696 (2025)
   PUBMED   40422199
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 254)
  AUTHORS   Wu,Y., Li,Y., Zhang,H., Ye,J., Li,M., Zhou,J., Xie,X., Yin,H.,
            Chen,M., Yang,G., Fan,S., Shi,B., Jiang,H., Shi,Q. and Ma,H.
  TITLE     S100PBP interacts with nucleoporin TPR and facilitates XY crossover
            formation in mice
  JOURNAL   EMBO Rep 26 (9), 2280-2299 (2025)
   PUBMED   40204913
REFERENCE   6  (residues 1 to 254)
  AUTHORS   Tanaka,S.S., Toyooka,Y., Akasu,R., Katoh-Fukui,Y., Nakahara,Y.,
            Suzuki,R., Yokoyama,M. and Noce,T.
  TITLE     The mouse homolog of Drosophila Vasa is required for the
            development of male germ cells
  JOURNAL   Genes Dev 14 (7), 841-853 (2000)
   PUBMED   10766740
REFERENCE   7  (residues 1 to 254)
  AUTHORS   Osterlund,C., Tohonen,V., Forslund,K.O. and Nordqvist,K.
  TITLE     Mage-b4, a novel melanoma antigen (MAGE) gene specifically
            expressed during germ cell differentiation
  JOURNAL   Cancer Res 60 (4), 1054-1061 (2000)
   PUBMED   10706124
REFERENCE   8  (residues 1 to 254)
  AUTHORS   Yuan,L., Liu,J.G., Zhao,J., Brundell,E., Daneholt,B. and Hoog,C.
  TITLE     The murine SCP3 gene is required for synaptonemal complex assembly,
            chromosome synapsis, and male fertility
  JOURNAL   Mol Cell 5 (1), 73-83 (2000)
   PUBMED   10678170
REFERENCE   9  (residues 1 to 254)
  AUTHORS   Chen,J., Silver,D.P., Walpita,D., Cantor,S.B., Gazdar,A.F.,
            Tomlinson,G., Couch,F.J., Weber,B.L., Ashley,T., Livingston,D.M.
            and Scully,R.
  TITLE     Stable interaction between the products of the BRCA1 and BRCA2
            tumor suppressor genes in mitotic and meiotic cells
  JOURNAL   Mol Cell 2 (3), 317-328 (1998)
   PUBMED   9774970
REFERENCE   10 (residues 1 to 254)
  AUTHORS   Klink,A., Lee,M. and Cooke,H.J.
  TITLE     The mouse synaptosomal complex protein gene Sycp3 maps to band C of
            chromosome 10
  JOURNAL   Mamm Genome 8 (5), 376-377 (1997)
   PUBMED   9133341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC138509.1 and BY386732.1.
            
            On Apr 9, 2009 this sequence version replaced NP_035647.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08485.1, BC132079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.94 cM"
     Protein         1..254
                     /product="synaptonemal complex protein 3"
                     /note="SCP-3"
                     /calculated_mol_wt=29178
     Region          1..65
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Site            55
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63520; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Region          71..76
                     /region_name="Interaction with DNA.
                     /evidence=ECO:0000250|UniProtKB:Q8IZU3"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Region          87..92
                     /region_name="Important for oligomerization and fiber
                     formation. /evidence=ECO:0000250|UniProtKB:Q8IZU3"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     Region          101..224
                     /region_name="Cor1"
                     /note="Cor1/Xlr/Xmr conserved region; pfam04803"
                     /db_xref="CDD:461436"
     Region          106..109
                     /region_name="Interaction with DNA.
                     /evidence=ECO:0000250|UniProtKB:Q8IZU3"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     Region          106..109
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70281.1)"
     Region          249..254
                     /region_name="Important for oligomerization and fiber
                     formation. /evidence=ECO:0000250|UniProtKB:Q8IZU3"
                     /note="propagated from UniProtKB/Swiss-Prot (P70281.1)"
     CDS             1..254
                     /gene="Sycp3"
                     /gene_synonym="Cor1; Scp3"
                     /coded_by="NM_011517.2:80..844"
                     /db_xref="CCDS:CCDS24111.1"
                     /db_xref="GeneID:20962"
                     /db_xref="MGI:MGI:109542"
ORIGIN      
        1 mlrgcgdsds speplskhlk mvpggrkhsg ksgkpplvdq pkkafdfekd dkdlsgseed
       61 vadekapvid khgkkrsagi iedvggevqn mlekfgadin kallakrkri emytkasfka
      121 snqkieqiwk tqqeeiqkln neysqqfmnv lqqweldiqk feeqgeklsn lfrqqqkifq
      181 qsrivqsqrm kaikqiheqf iksledvekn ndnlftgtqs elkkemamlq kkvmmetqqq
      241 emanvrkslq smlf
//
LOCUS       NP_031617                416 aa            linear   ROD 27-AUG-2025
DEFINITION  calreticulin precursor [Mus musculus].
ACCESSION   NP_031617
VERSION     NP_031617.1
DBSOURCE    REFSEQ: accession NM_007591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Chen,C.C., Hsu,L.W., Chen,K.D., Chiu,K.W., Kung,C.P., Li,S.R.,
            Chen,C.L. and Huang,K.T.
  TITLE     Calreticulin regulates hepatic stellate cell activation through
            modulating TGF-beta-induced Smad signaling
  JOURNAL   Cell Calcium 121, 102895 (2024)
   PUBMED   38703416
  REMARK    GeneRIF: Calreticulin regulates hepatic stellate cell activation
            through modulating TGF-beta-induced Smad signaling.
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Haage,T.R., Charakopoulos,E., Bhuria,V., Baldauf,C.K., Korthals,M.,
            Handschuh,J., Muller,P., Li,J., Harit,K., Nishanth,G., Frey,S.,
            Bottcher,M., Fischer,K.D., Dudeck,J., Dudeck,A., Lipka,D.B.,
            Schraven,B., Green,A.R., Muller,A.J., Mougiakakos,D. and Fischer,T.
  TITLE     Neutrophil-specific expression of JAK2-V617F or CALRmut induces
            distinct inflammatory profiles in myeloproliferative neoplasia
  JOURNAL   J Hematol Oncol 17 (1), 43 (2024)
   PUBMED   38853260
  REMARK    GeneRIF: Neutrophil-specific expression of JAK2-V617F or CALRmut
            induces distinct inflammatory profiles in myeloproliferative
            neoplasia.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Holl,K., Chatain,N., Krapp,S., Baumeister,J., Maie,T., Schmitz,S.,
            Scheufen,A., Brock,N., Koschmieder,S. and Moreno-Andres,D.
  TITLE     Calreticulin and JAK2V617F driver mutations induce distinct mitotic
            defects in myeloproliferative neoplasms
  JOURNAL   Sci Rep 14 (1), 2810 (2024)
   PUBMED   38308077
  REMARK    GeneRIF: Calreticulin and JAK2V617F driver mutations induce
            distinct mitotic defects in myeloproliferative neoplasms.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Grockowiak,E., Korn,C., Rak,J., Lysenko,V., Hallou,A.,
            Panvini,F.M., Williams,M., Fielding,C., Fang,Z.,
            Khatib-Massalha,E., Garcia-Garcia,A., Li,J., Khorshed,R.A.,
            Gonzalez-Anton,S., Baxter,E.J., Kusumbe,A., Wilkins,B.S., Green,A.,
            Simons,B.D., Harrison,C.N., Green,A.R., Lo Celso,C.,
            Theocharides,A.P.A. and Mendez-Ferrer,S.
  TITLE     Different niches for stem cells carrying the same oncogenic driver
            affect pathogenesis and therapy response in myeloproliferative
            neoplasms
  JOURNAL   Nat Cancer 4 (8), 1193-1209 (2023)
   PUBMED   37550517
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Mazzarella,R.A., Gold,P., Cunningham,M. and Green,M.
  TITLE     Determination of the sequence of an expressible cDNA clone encoding
            ERp60/calregulin by the use of a novel nested set method
  JOURNAL   Gene 120 (2), 217-225 (1992)
   PUBMED   1398135
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Michalak,M., Milner,R.E., Burns,K. and Opas,M.
  TITLE     Calreticulin
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 681-692 (1992)
   PUBMED   1497605
  REMARK    Review article
REFERENCE   8  (residues 1 to 416)
  AUTHORS   Abe,H., Watanabe,M., Goto,K., Sakagami,H. and Kondo,H.
  TITLE     Localization of gene expression of calreticulin in the brain of
            adult mouse
  JOURNAL   Brain Res Mol Brain Res 14 (4), 337-343 (1992)
   PUBMED   1326696
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Smith,M.J. and Koch,G.L.
  TITLE     Multiple zones in the sequence of calreticulin (CRP55, calregulin,
            HACBP), a major calcium binding ER/SR protein
  JOURNAL   EMBO J 8 (12), 3581-3586 (1989)
   PUBMED   2583110
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Tuan,R.S. and Kirwin,J.J.
  TITLE     Mouse placental 57-kDa calcium-binding protein: I. Cloning of cDNA
            and characterization of developmental expression
  JOURNAL   Differentiation 37 (2), 98-103 (1988)
   PUBMED   2456241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291864.1, AK075605.1, AK160197.1 and BB727203.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075605.1, X14926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.21 cM"
     Protein         1..416
                     /product="calreticulin precursor"
                     /note="CRP55; ERp60; HACBP; endoplasmic reticulum resident
                     protein 60"
                     /calculated_mol_wt=46348
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1665
     mat_peptide     18..416
                     /product="Calreticulin. /id=PRO_0000004174"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
                     /calculated_mol_wt=46348
     Region          18..197
                     /region_name="N-domain"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          23..332
                     /region_name="Calreticulin"
                     /note="Calreticulin family; pfam00262"
                     /db_xref="CDD:459737"
     Site            48
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P27797; propagated from
                     UniProtKB/Swiss-Prot (P14211.1)"
     Site            159
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P27797; propagated from
                     UniProtKB/Swiss-Prot (P14211.1)"
     Region          191..255
                     /region_name="4 X approximate repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          193..277
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          198..308
                     /region_name="P-domain"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Site            209
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P14211.1)"
     Region          237..270
                     /region_name="Interaction with PPIB.
                     /evidence=ECO:0000269|PubMed:20801878"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          259..297
                     /region_name="3 X approximate repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          309..416
                     /region_name="C-domain"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          350..416
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     Region          413..416
                     /region_name="Prevents secretion from ER"
                     /note="propagated from UniProtKB/Swiss-Prot (P14211.1)"
     CDS             1..416
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /coded_by="NM_007591.3:134..1384"
                     /db_xref="CCDS:CCDS22479.1"
                     /db_xref="GeneID:12317"
                     /db_xref="MGI:MGI:88252"
ORIGIN      
        1 mllsvplllg llglaaadpa iyfkeqfldg dawtnrwves khksdfgkfv lssgkfygdl
       61 ekdkglqtsq darfyalsak fepfsnkgqt lvvqftvkhe qnidcgggyv klfpsgldqk
      121 dmhgdseyni mfgpdicgpg tkkvhvifny kgknvlinkd irckddefth lytlivrpdn
      181 tyevkidnsq vesgsleddw dflppkkikd pdaakpedwd erakiddptd skpedwdkpe
      241 hipdpdakkp edwdeemdge weppviqnpe ykgewkprqi dnpdykgtwi hpeidnpeys
      301 pdaniyayds favlgldlwq vksgtifdnf litndeayae efgnetwgvt kaaekqmkdk
      361 qdeeqrlkee eedkkrkeee eaedkedddd rdededeede keedeeespg qakdel
//
LOCUS       NP_001412521             706 aa            linear   ROD 27-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform 2 [Mus
            musculus].
ACCESSION   NP_001412521 XP_006518493
VERSION     NP_001412521.1
DBSOURCE    REFSEQ: accession NM_001425592.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 706)
  AUTHORS   He,W., Marchuk,H., Koeberl,D., Kasumov,T., Chen,X. and Zhang,G.F.
  TITLE     Fasting alleviates metabolic alterations in mice with propionyl-CoA
            carboxylase deficiency due to Pcca mutation
  JOURNAL   Commun Biol 7 (1), 659 (2024)
   PUBMED   38811689
  REMARK    GeneRIF: Fasting alleviates metabolic alterations in mice with
            propionyl-CoA carboxylase deficiency due to Pcca mutation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 706)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 706)
  AUTHORS   Soria,L.R., Makris,G., D'Alessio,A.M., De Angelis,A., Boffa,I.,
            Pravata,V.M., Rufenacht,V., Attanasio,S., Nusco,E., Arena,P.,
            Ferenbach,A.T., Paris,D., Cuomo,P., Motta,A., Nitzahn,M.,
            Lipshutz,G.S., Martinez-Pizarro,A., Richard,E., Desviat,L.R.,
            Haberle,J., van Aalten,D.M.F. and Brunetti-Pierri,N.
  TITLE     O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and
            promotes ureagenesis
  JOURNAL   Nat Commun 13 (1), 5212 (2022)
   PUBMED   36064721
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 706)
  AUTHORS   Subramanian,C., Frank,M.W., Tangallapally,R., Yun,M.K., Edwards,A.,
            White,S.W., Lee,R.E., Rock,C.O. and Jackowski,S.
  TITLE     Pantothenate kinase activation relieves coenzyme A sequestration
            and improves mitochondrial function in mice with propionic acidemia
  JOURNAL   Sci Transl Med 13 (611), eabf5965 (2021)
   PUBMED   34524863
REFERENCE   5  (residues 1 to 706)
  AUTHORS   Jiang,L., Park,J.S., Yin,L., Laureano,R., Jacquinet,E., Yang,J.,
            Liang,S., Frassetto,A., Zhuo,J., Yan,X., Zhu,X., Fortucci,S.,
            Hoar,K., Mihai,C., Tunkey,C., Presnyak,V., Benenato,K.E.,
            Lukacs,C.M., Martini,P.G.V. and Guey,L.T.
  TITLE     Dual mRNA therapy restores metabolic function in long-term studies
            in mice with propionic acidemia
  JOURNAL   Nat Commun 11 (1), 5339 (2020)
   PUBMED   33087718
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 706)
  AUTHORS   Guenzel,A.J., Hofherr,S.E., Hillestad,M., Barry,M., Weaver,E.,
            Venezia,S., Kraus,J.P., Matern,D. and Barry,M.A.
  TITLE     Generation of a hypomorphic model of propionic acidemia amenable to
            gene therapy testing
  JOURNAL   Mol Ther 21 (7), 1316-1323 (2013)
   PUBMED   23648696
REFERENCE   7  (residues 1 to 706)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (residues 1 to 706)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 706)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 706)
  AUTHORS   Miyazaki,T., Ohura,T., Kobayashi,M., Shigematsu,Y., Yamaguchi,S.,
            Suzuki,Y., Hata,I., Aoki,Y., Yang,X., Minjares,C., Haruta,I.,
            Uto,H., Ito,Y. and Muller,U.
  TITLE     Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase
            and its rescue by postnatal, liver-specific supplementation via a
            transgene
  JOURNAL   J Biol Chem 276 (38), 35995-35999 (2001)
   PUBMED   11461925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144798.4, AC169511.1 and AC154499.2.
            
            On Nov 22, 2023 this sequence version replaced XP_006518493.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422586.409262.1,
                                           SRR7345562.738202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.99 cM"
     Protein         1..706
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform 2"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase alpha chain,
                     mitochondrial; propanoyl-CoA:carbon dioxide ligase subunit
                     alpha; propionyl CoA-carboxylase alpha; PCCase subunit
                     alpha"
                     /calculated_mol_wt=77926
     CDS             1..706
                     /gene="Pcca"
                     /coded_by="NM_001425592.1:37..2157"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
ORIGIN      
        1 magqwvrtva llaarrhwrr ssqqqllgtl khapvysyqc lvvsrslssv eyepkektfd
       61 kilianrgei acrviktckk mgiktvaihs dvdassvhvk madeavcvgp aptsksylnm
      121 daimeaikkt raqavhpgyg flsenkefak rlaaedvtfi gpdthaiqam gdkiesklla
      181 krakvntipg fdgvvkdade avriareigy pvmikasagg ggkgmriawd deetrdgfrf
      241 ssqeaassfg ddrlliekfi dnprhieiqv lgdkhgnalw lnerecsiqr rnqkvveeap
      301 sifldpetrq amgeqavala kavkyssagt veflvdsqkn fyflemntrl qvehpvteci
      361 tgldlvqemi lvakgyplrh kqedipisgw avecrvyaed pyksfglpsi grlsqyqepi
      421 hlpgvrvdsg iqpgsdisiy ydpmisklvt ygsdraealk rmedaldnyv irgvthnipl
      481 lreviintrf vkgdistkfl sdvypdgfkg htltlsernq llaiassvfv asqlraqrfq
      541 ehsrvpvirp dvakwelsvk lhdedhtvva snngpaftve vdgsklnvts twnlasplls
      601 vnvdgtqrtv qykvhiltkl aaelnkfmle kvpkdtsstl cspmpgvvva vsvkpgdmva
      661 egqeicviea mkmqnsmtag kmgkvklvhc kagdtvgegd llvele
//
LOCUS       NP_001231130             422 aa            linear   ROD 27-AUG-2025
DEFINITION  paired box protein Pax-6 isoform 2 [Mus musculus].
ACCESSION   NP_001231130
VERSION     NP_001231130.1
DBSOURCE    REFSEQ: accession NM_001244201.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Georgala,P.A., Carr,C.B. and Price,D.J.
  TITLE     The role of Pax6 in forebrain development
  JOURNAL   Dev Neurobiol 71 (8), 690-709 (2011)
   PUBMED   21538923
  REMARK    Review article
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Kim,J. and Lauderdale,J.D.
  TITLE     Analysis of Pax6 expression using a BAC transgene reveals the
            presence of a paired-less isoform of Pax6 in the eye and olfactory
            bulb
  JOURNAL   Dev Biol 292 (2), 486-505 (2006)
   PUBMED   16464444
  REMARK    GeneRIF: Pax6 expression, analyzed using a BAC transgene, revealed
            the presence of a paired-less isoform in the eye and olfactory
            bulb.
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Xu,P.X., Zhang,X., Heaney,S., Yoon,A., Michelson,A.M. and Maas,R.L.
  TITLE     Regulation of Pax6 expression is conserved between mice and flies
  JOURNAL   Development 126 (2), 383-395 (1999)
   PUBMED   9847251
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Ton,C.C., Miwa,H. and Saunders,G.F.
  TITLE     Small eye (Sey): cloning and characterization of the murine homolog
            of the human aniridia gene
  JOURNAL   Genomics 13 (2), 251-256 (1992)
   PUBMED   1612585
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Hill,R.E., Favor,J., Hogan,B.L., Ton,C.C., Saunders,G.F.,
            Hanson,I.M., Prosser,J., Jordan,T., Hastie,N.D. and van
            Heyningen,V.
  TITLE     Mouse small eye results from mutations in a paired-like
            homeobox-containing gene
  JOURNAL   Nature 354 (6354), 522-525 (1991)
   PUBMED   1684639
  REMARK    Erratum:[Nature. 1992 Feb 20;355(6362):750. doi: 10.1038/355750a0.
            PMID: 1346927]
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Walther,C. and Gruss,P.
  TITLE     Pax-6, a murine paired box gene, is expressed in the developing CNS
  JOURNAL   Development 113 (4), 1435-1449 (1991)
   PUBMED   1687460
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Theiler,K., Varnum,D.S. and Stevens,L.C.
  TITLE     Development of Dickie's small eye, a mutation in the house mouse
  JOURNAL   Anat Embryol (Berl) 155 (1), 81-86 (1978)
   PUBMED   103464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK032616.1, CA751997.1,
            CX565124.1, CN539723.1, AK139054.1 and AL512589.4.
            
            Summary: This gene encodes a homeobox-containing protein that
            functions as a regulator of transcription. It plays a key role in
            the development of neural tissues, particularly the eye. Activity
            of this protein is also required for expression of glucagon in the
            pancreas. This gene is regulated by multiple enhancers located up
            to tens or hundreds of kilobases upstream and downstream of the
            transcription start sites. Mutations in this gene or deletion of
            these regulatory elements results in severe defects in eye
            development. Alternative splicing and the use of alternative
            promoters results in multiple transcript variants, some of which
            encode proteins that lack the N-terminal paired domain. [provided
            by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (4) lacks an in-frame exon in the
            5' coding region compared to variant 1. It initiates from the P0
            promoter. The encoded isoform (2) is shorter than isoform 1.
            Variants 4, 5, and 6 encode the same protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028059.1, BC036957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.31 cM"
     Protein         1..422
                     /product="paired box protein Pax-6 isoform 2"
                     /note="paired box protein Pax-6; oculorhombin; Dickie's
                     small eye; paired box gene 6"
                     /calculated_mol_wt=46552
     Region          4..128
                     /region_name="PAX"
                     /note="Paired Box domain; smart00351"
                     /db_xref="CDD:128645"
     Region          7..63
                     /region_name="PAI subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P63015.1)"
     Site            order(9..10,15,17..19,21,26,38,40,49,52,54..55,59,68..74,
                     76..79,98..100,119,121..122,125,128)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     Region          82..130
                     /region_name="RED subdomain.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00381"
                     /note="propagated from UniProtKB/Swiss-Prot (P63015.1)"
     Region          162..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63015.1)"
     Region          212..267
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          269..311
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63015.1)"
     Region          345..422
                     /region_name="Required for suppression of NFATC1-mediated
                     transcription. /evidence=ECO:0000269|PubMed:23990468"
                     /note="propagated from UniProtKB/Swiss-Prot (P63015.1)"
     CDS             1..422
                     /gene="Pax6"
                     /gene_synonym="1500038E17Rik; AEY11; Dey; Gsfaey11; Pax-6;
                     Sey"
                     /coded_by="NM_001244201.2:286..1554"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS57181.1"
                     /db_xref="GeneID:18508"
                     /db_xref="MGI:MGI:97490"
ORIGIN      
        1 mqnshsgvnq lggvfvngrp lpdstrqkiv elahsgarpc disrilqvsn gcvskilgry
       61 yetgsirpra iggskprvat pevvskiaqy krecpsifaw eirdrllseg vctndnipsv
      121 ssinrvlrnl asekqqmgad gmydklrmln gqtgswgtrp gwypgtsvpg qptqdgcqqq
      181 egggentnsi ssngedsdea qmrlqlkrkl qrnrtsftqe qiealekefe rthypdvfar
      241 erlaakidlp eariqvwfsn rrakwrreek lrnqrrqasn tpshipisss fstsvyqpip
      301 qpttpvssft sgsmlgrtdt altntysalp pmpsftmann lpmqppvpsq tssyscmlpt
      361 spsvngrsyd tytpphmqth mnsqpmgtsg ttstglispg vsvpvqvpgs epdmsqywpr
      421 lq
//
LOCUS       NP_001239242            2454 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor corepressor 1 isoform 1 [Mus musculus].
ACCESSION   NP_001239242
VERSION     NP_001239242.1
DBSOURCE    REFSEQ: accession NM_001252313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2454)
  AUTHORS   Qian,S., Zhang,C., Li,W., Song,S., Lin,G., Cheng,Z., Zhou,W.,
            Yin,H., Wang,Y., Li,H., Shen,Y.H. and Sun,Z.
  TITLE     Enzyme-independent functions of HDAC3 in the adult heart
  JOURNAL   Acta Pharm Sin B 15 (7), 3561-3574 (2025)
   PUBMED   40698142
REFERENCE   2  (residues 1 to 2454)
  AUTHORS   Ritter,M.J., Amano,I., van der Spek,A.H., Gower,A.C.,
            Undeutsch,H.J., Rodrigues,V.A.P., Daniel,H.E. and Hollenberg,A.N.
  TITLE     Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism
            via Intestinal Regulation of Carbohydrate Transport
  JOURNAL   Endocrinology 165 (9) (2024)
   PUBMED   39106294
REFERENCE   3  (residues 1 to 2454)
  AUTHORS   Teichmann,T., Malacarne,P., Zehr,S., Gunther,S., Pfluger-Muller,B.,
            Warwick,T. and Brandes,R.P.
  TITLE     NCoR1 limits angiogenic capacity by altering Notch signaling
  JOURNAL   J Mol Cell Cardiol 188, 65-78 (2024)
   PUBMED   38359551
  REMARK    GeneRIF: NCoR1 limits angiogenic capacity by altering Notch
            signaling.
REFERENCE   4  (residues 1 to 2454)
  AUTHORS   Abe,Y., Kofman,E.R., Ouyang,Z., Cruz-Becerra,G., Spann,N.J.,
            Seidman,J.S., Troutman,T.D., Stender,J.D., Taylor,H., Fan,W.,
            Link,V.M., Shen,Z., Sakai,J., Downes,M., Evans,R.M., Kadonaga,J.T.,
            Rosenfeld,M.G. and Glass,C.K.
  TITLE     A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator
            complex formation for inflammatory gene activation
  JOURNAL   Proc Natl Acad Sci U S A 121 (2), e2316104121 (2024)
   PUBMED   38165941
REFERENCE   5  (residues 1 to 2454)
  AUTHORS   Contreras-Jurado,C., Montero-Pedrazuela,A., Perez,R.F., Alemany,S.,
            Fraga,M.F. and Aranda,A.
  TITLE     The thyroid hormone enhances mouse embryonic fibroblasts
            reprogramming to pluripotent stem cells: role of the nuclear
            receptor corepressor 1
  JOURNAL   Front Endocrinol (Lausanne) 14, 1235614 (2023)
   PUBMED   38107517
  REMARK    GeneRIF: The thyroid hormone enhances mouse embryonic fibroblasts
            reprogramming to pluripotent stem cells: role of the nuclear
            receptor corepressor 1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2454)
  AUTHORS   Alland,L., Muhle,R., Hou,H. Jr., Potes,J., Chin,L.,
            Schreiber-Agus,N. and DePinho,R.A.
  TITLE     Role for N-CoR and histone deacetylase in Sin3-mediated
            transcriptional repression
  JOURNAL   Nature 387 (6628), 49-55 (1997)
   PUBMED   9139821
REFERENCE   7  (residues 1 to 2454)
  AUTHORS   Heinzel,T., Lavinsky,R.M., Mullen,T.M., Soderstrom,M.,
            Laherty,C.D., Torchia,J., Yang,W.M., Brard,G., Ngo,S.D.,
            Davie,J.R., Seto,E., Eisenman,R.N., Rose,D.W., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     A complex containing N-CoR, mSin3 and histone deacetylase mediates
            transcriptional repression
  JOURNAL   Nature 387 (6628), 43-48 (1997)
   PUBMED   9139820
REFERENCE   8  (residues 1 to 2454)
  AUTHORS   Seol,W., Mahon,M.J., Lee,Y.K. and Moore,D.D.
  TITLE     Two receptor interacting domains in the nuclear hormone receptor
            corepressor RIP13/N-CoR
  JOURNAL   Mol Endocrinol 10 (12), 1646-1655 (1996)
   PUBMED   8961273
REFERENCE   9  (residues 1 to 2454)
  AUTHORS   Horlein,A.J., Naar,A.M., Heinzel,T., Torchia,J., Gloss,B.,
            Kurokawa,R., Ryan,A., Kamei,Y., Soderstrom,M., Glass,C.K. et al.
  TITLE     Ligand-independent repression by the thyroid hormone receptor
            mediated by a nuclear receptor co-repressor
  JOURNAL   Nature 377 (6548), 397-404 (1995)
   PUBMED   7566114
REFERENCE   10 (residues 1 to 2454)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX248411.3 and AL596110.15.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35312.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.08 cM"
     Protein         1..2454
                     /product="nuclear receptor corepressor 1 isoform 1"
                     /note="nuclear receptor corepressor 1; N-CoR1; retinoid X
                     receptor-interacting protein 13"
                     /calculated_mol_wt=270657
     Region          148..178
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          150..239
                     /region_name="GPS2_interact"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     pfam15784"
                     /db_xref="CDD:464868"
     Site            173
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          207..232
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            225
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          255..313
                     /region_name="Interaction with SIN3A/B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          441..483
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(441,470..471,473..474,476..478,480..482)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     Region          498..632
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          627..670
                     /region_name="Myb_DNA-binding"
                     /note="Myb-like DNA-binding domain; pfam00249"
                     /db_xref="CDD:459731"
     Region          678..909
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          <711..>910
                     /region_name="MDN1"
                     /note="Midasin, AAA ATPase with vWA domain, involved in
                     ribosome maturation [Translation, ribosomal structure and
                     biogenesis]; COG5271"
                     /db_xref="CDD:444083"
     Site            1012
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1035..1059
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1123
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1208
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1275
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1293
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1348
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1379
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1424
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1451..1545
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1482
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1511..2454
                     /region_name="Interaction with C1D.
                     /evidence=ECO:0000269|PubMed:9405624"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1599
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1698..1781
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1903..1940
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1950..1954
                     /region_name="CORNR box 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          1960..2061
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1994
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            1998
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2051..2130
                     /region_name="ID1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2066..2069
                     /region_name="Required for interaction with RARA in the
                     absence of its ligand. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2074..2078
                     /region_name="CORNR box 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2089..2175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2117
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9WUB5; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2166
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2199
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2227..2288
                     /region_name="ID2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2278..2282
                     /region_name="CORNR box 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Region          2304..2397
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2413
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75376; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2450
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     Site            2452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q60974.1)"
     CDS             1..2454
                     /gene="Ncor1"
                     /gene_synonym="5730405M06Rik; A230020K14Rik; mKIAA1047;
                     N-CoR; RIP13; Rxrip13"
                     /coded_by="NM_001252313.1:71..7435"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS56781.1"
                     /db_xref="GeneID:20185"
                     /db_xref="MGI:MGI:1349717"
ORIGIN      
        1 msssgyppnq gafsteqsry pshsvqytfp strhqqefav pdyrsshiev sqasqllqqq
       61 qqqqqlrrrp sllsefhpgs drpqerrtgy eqfhsgpspv dhdsleskrp rlepvsdahf
      121 qrvsaavlpl vhslpeglrs sadakkdsaf gskheapssp lagqpcgddq naspsklske
      181 eliqsmdrvd reiakveqqi lklkkkqqql eeeaakppep ekpvspppve qkhrsivqii
      241 ydenrkkaee ahkifeglgp kvelplynqp sdtkvyheni ktnqvmrkkl ilffkrrnha
      301 rkqreqkicq rydqlmeawe kkvdriennp rrkakesktr eyyekqfpei rkqreqqerf
      361 qrvgqrgagl satiarsehe iseiidglse qennekqmrq lsvippmmfd aeqrrvkfin
      421 mnglmedpmk vykdrqfmnv wtdhekeifk dkfiqhpknf gliasylerk svpdcvlyyy
      481 ltkknenyka lvrrnygkrr grnqqiarps qeekveekee dkaektekke eekkddeekd
      541 dkedskettk ekdrteatae epeereqvtp rgrktansqg rrkgrvtrsm tseaaaanaa
      601 aaateepppp lppppepist epvetsrwte eemevakkgl vehgrnwaai akmvgtksea
      661 qcknfyfnyk rrhnldnllq qhkqkasrkp reerdvsqce svastvsaqe dedieasnee
      721 enpedsegae nssdtesaps pspveaakss edssenaasr gntepvaele attdpapcas
      781 pssavpttkp aeresveaqv tdsasaetae pmdvdheecg aegssvldpp aptkadsvdp
      841 emqvpentas kgegdakerd lestsektea rdedvvvaeq ierpepqsdd dssatcsade
      901 gvdgeperqr vfpmdakpsl ltppgsilis spikpnpldl pqlqhraavi ppmvsctpcn
      961 ipigtpvsgy alyqrhikam hesalleeqr qrqeqvdlec rsstspcsts kspnrewevl
     1021 qpaphqvitn lpegvrlptt rptrppppli psskttvase kpsfimggsi sqgtpgtyls
     1081 shnqaypqea pkpsvgsisl glprqqestk aapltyikqe efsprsqnsq pegllvraqh
     1141 egvvrgtaga vqegsitrgt paskisveti sslrgsitqg tpalpqagip tealvkgpvs
     1201 rmpieesspe kvreeaaskg hviyegksgh ilsydnikna regtrsprta hemslkrsye
     1261 avegsikqgm smrespvsap leglicralp rgsphsdlke rtvlsgsimq gtprataesf
     1321 edglkypkqi kresppiraf egaitkgkpy dgittikemg rsiheiprqd iltqesrktp
     1381 evvqstrpii egsisqgtpi kfdnnsgqsa ikhnvkslit gpsklprgml eivpenikvv
     1441 ergkyedvka gepvrarhts vvssgpsvlr stlheapkaq lspglyddss arrtpvsyqn
     1501 tisrgspmmn rtsdvsssks asherkstlt ptqresipak spvpgvdpvv shspfdphhr
     1561 ssaagevyrs hlpthldpam pfhraldpaa ayllqrqlsp tpgypsqyql yamentrqti
     1621 lndyitsqqm qvnlrpdvtr glspreqplg lpypatrgii dltnmpptil vphaggtstp
     1681 pmdrityipg tqvtfpprpy naaslspghp thlaaaasae rererereke rerererere
     1741 rereriaaap adlylrpgse qpgrpgshgy vrspspsvrt qetilqqrps vfqgtngtsv
     1801 itpldptaql rimplpsggp sisqglpasr yntaadalaa lvdaaasapq mdvsktkesk
     1861 heaarleenl rsrsaavseq qqleqknlev ekrsvqcvct ssalpsgkaq phasvvysea
     1921 gkdkgpppks ryeeelrtrg kttitaanfi dviitrqias dkdarergsq ssdsssslss
     1981 hryetasdai evispasspa ppqekpqayq pdmvkanqae nestrqyegp lhhyrsqqes
     2041 pspqqqpplp pssqsegmgq vprthrlitl adhicqiitq dfarnqvpsq pststfqtsp
     2101 salsstpvrt ktssryspes qsqtvlhprp gprvspenlv dksrgsrpgk spershipse
     2161 pyepisppqg pavhekqdsm lllsqrgvdp aeqrsdsrsp gsisylpsff tklestspmv
     2221 kskkqeifrk lnssgggdsd maaaqpgtei fnlpavttsg avssrshsfa dpasnlgled
     2281 iirkalmgsf ddkvedhgvv mshpvgimpg sastsvvtss earrdegeps phagvckpkl
     2341 inksnsrksk spipgqsylg terpssvssv hsegdyhrqt pgwawedrps stgstqfpyn
     2401 pltirmlsst pptqiacaps aitqaaphqq nriwerepap llsaqyetls dsdd
//
LOCUS       NP_001408086             378 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform j [Mus musculus].
ACCESSION   NP_001408086 XP_006502864
VERSION     NP_001408086.1
DBSOURCE    REFSEQ: accession NM_001421157.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 378)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_006502864.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.3793898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..378
                     /product="ELAV-like protein 4 isoform j"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=41378
     Region          41..377
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..378
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421157.1:476..1612"
                     /note="isoform j is encoded by transcript variant 13"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 miistmepqv sngptsntsn gpssnnrncp spmqtgaatd dsktnlivny lpqnmtqeef
       61 rslfgsigei escklvrdki tgqslgygfv nyidpkdaek aintlnglrl qtktikvsya
      121 rpssasirda nlyvsglpkt mtqkeleqlf sqygriitsr ilvdqvtgvs rgvgfirfdk
      181 rieaeeaikg lngqkpsgat epitvkfann psqkssqall sqlyqspnrr ypgplhhqaq
      241 rfrldnllnm aygvkrlmsg pvppsacppr fspitidgmt slvgmnipgh tgtgwcifvy
      301 nlspdsdesv lwqlfgpfga vnnvkvirdf ntnkckgfgf vtmtnydeaa maiaslngyr
      361 lgdrvlqvsf ktnkahks
//
LOCUS       NP_034607                573 aa            linear   ROD 27-AUG-2025
DEFINITION  60 kDa heat shock protein, mitochondrial [Mus musculus].
ACCESSION   NP_034607
VERSION     NP_034607.3
DBSOURCE    REFSEQ: accession NM_010477.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Li,W., Zhu,W., Zhu,Z., Xie,H., Ali,T., Yu,Z. and Li,S.
  TITLE     Astrocytic-HSP60 Depletion Contributed to Autophagy Defects of
            Astrocytes and Depressive-Like Behaviors in Male Mice
  JOURNAL   Glia 73 (10), 2130-2146 (2025)
   PUBMED   40642774
REFERENCE   2  (residues 1 to 573)
  AUTHORS   Zhu,W., Cheng,Y., Lang,Z., Li,W. and Wei,X.
  TITLE     Astrocytic HSP60 Deletion Induced Astrocyte Senescence and
            Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF
            Pathway
  JOURNAL   J Neurosci Res 103 (6), e70054 (2025)
   PUBMED   40448367
REFERENCE   3  (residues 1 to 573)
  AUTHORS   Liu,D.H., Li,F., Yang,R.Z., Wu,Z., Meng,X.Y., Li,S.M., Li,W.X.,
            Li,J.K., Wang,D.D., Wang,R.Y., Li,S.A., Liu,P.P. and Kang,J.S.
  TITLE     Pulmonary mitochondrial DNA release and activation of the
            cGAS-STING pathway in Lethal Stx12 knockout mice
  JOURNAL   Cell Commun Signal 23 (1), 174 (2025)
   PUBMED   40200300
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 573)
  AUTHORS   Li,W., Luo,Y., Ali,T., Huang,Y., Yu,Z.J., Hao,L. and Li,S.
  TITLE     Hsp60 deletion in cholinergic neurons: Impact on neuroinflammation
            and memory
  JOURNAL   Int Immunopharmacol 141, 113022 (2024)
   PUBMED   39213869
REFERENCE   5  (residues 1 to 573)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   6  (residues 1 to 573)
  AUTHORS   Brudzynski,K., Martinez,V. and Gupta,R.S.
  TITLE     Immunocytochemical localization of heat-shock protein 60-related
            protein in beta-cell secretory granules and its altered
            distribution in non-obese diabetic mice
  JOURNAL   Diabetologia 35 (4), 316-324 (1992)
   PUBMED   1516759
REFERENCE   7  (residues 1 to 573)
  AUTHORS   Ikawa,S. and Weinberg,R.A.
  TITLE     An interaction between p21ras and heat shock protein hsp60, a
            chaperonin
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2012-2016 (1992)
   PUBMED   1347942
REFERENCE   8  (residues 1 to 573)
  AUTHORS   Elias,D., Reshef,T., Birk,O.S., van der Zee,R., Walker,M.D. and
            Cohen,I.R.
  TITLE     Vaccination against autoimmune mouse diabetes with a T-cell epitope
            of the human 65-kDa heat shock protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3088-3091 (1991)
   PUBMED   1707531
REFERENCE   9  (residues 1 to 573)
  AUTHORS   Lotscher,E. and Allison,J.P.
  TITLE     Nucleotide and deduced amino acid sequence of a murine cDNA clone
            encoding one member of the hsp65 multigene family
  JOURNAL   Nucleic Acids Res 18 (23), 7153 (1990)
   PUBMED   2263486
REFERENCE   10 (residues 1 to 573)
  AUTHORS   Venner,T.J. and Gupta,R.S.
  TITLE     Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA
  JOURNAL   Biochim Biophys Acta 1087 (3), 336-338 (1990)
   PUBMED   1979012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY014148.1, AK143882.1 and BF607107.1.
            
            On Apr 17, 2008 this sequence version replaced NP_034607.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146831.1, SRR1660819.118464.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.01 cM"
     Protein         1..573
                     /product="60 kDa heat shock protein, mitochondrial"
                     /EC_number="5.6.1.7"
                     /note="heat shock 60kDa protein 1 (chaperonin); chaperonin
                     60; 60 kDa chaperonin; heat shock protein 60;
                     mitochondrial matrix protein P1; heat shock protein, 60
                     kDa"
                     /calculated_mol_wt=57926
     transit_peptide 1..26
                     /note="Mitochondrion.
                     /evidence=ECO:0000269|PubMed:7523108; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
                     /calculated_mol_wt=3048
     mat_peptide     27..573
                     /product="60 kDa heat shock protein, mitochondrial.
                     /id=PRO_0000005027"
                     /note="propagated from UniProtKB/Swiss-Prot (P63038.1)"
                     /calculated_mol_wt=57926
     Region          28..548
                     /region_name="GroEL"
                     /note="GroEL_like type I chaperonin. Chaperonins are
                     involved in productive folding of proteins. They share a
                     common general morphology, a double toroid of 2 stacked
                     rings, each composed of 7-9 subunits. The symmetry of type
                     I is seven-fold and they are found...; cd03344"
                     /db_xref="CDD:239460"
     Site            order(28,32,49,60..63,65,70..71,73,83,85,93,97,100,221,
                     253,281,409,411,484,538,541..547)
                     /site_type="other"
                     /note="ring oligomerisation interface [polypeptide
                     binding]"
                     /db_xref="CDD:239460"
     Site            order(55..57,111,115,174,423,440,479,518,520)
                     /site_type="other"
                     /note="ATP/Mg binding site [chemical binding]"
                     /db_xref="CDD:239460"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            82
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            87
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            91
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            125
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            130
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            order(133,459,477,486,488..489,492)
                     /site_type="active"
                     /note="stacking interactions [active]"
                     /db_xref="CDD:239460"
     Site            133
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            156
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            order(165,210,217,400,434..435)
                     /site_type="other"
                     /note="hinge regions"
                     /db_xref="CDD:239460"
     Site            191
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            202
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            205
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            218
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            236
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            249
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            250
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            269
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            292
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            314
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            352
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            359
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            389
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            396
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            455
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            469
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            481
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10809; propagated from
                     UniProtKB/Swiss-Prot (P63038.1)"
     CDS             1..573
                     /gene="Hspd1"
                     /gene_synonym="60kDa; CPN60; HSP-60; HSP-65; Hsp60"
                     /coded_by="NM_010477.4:157..1878"
                     /db_xref="CCDS:CCDS35569.1"
                     /db_xref="GeneID:15510"
                     /db_xref="MGI:MGI:96242"
ORIGIN      
        1 mlrlptvlrq mrpvsralap hltrayakdv kfgadaralm lqgvdllada vavtmgpkgr
       61 tviieqswgs pkvtkdgvtv aksidlkdky knigaklvqd vanntneeag dgtttatvla
      121 rsiakegfek iskganpvei rrgvmlavda viaelkkqsk pvttpeeiaq vatisangdk
      181 digniisdam kkvgrkgvit vkdgktlnde leiiegmkfd rgyispyfin tskgqkcefq
      241 dayvllsekk issvqsivpa leianahrkp lviiaedvdg ealstlvlnr lkvglqvvav
      301 kapgfgdnrk nqlkdmaiat ggavfgeegl nlnledvqah dlgkvgeviv tkddamllkg
      361 kgdkahiekr iqeiteqldi ttseyekekl nerlaklsdg vavlkvggts dvevnekkdr
      421 vtdalnatra aveegivlgg gcallrcipa ldslkpaned qkigieiikr alkipamtia
      481 knagvegsli vekilqssse vgydamlgdf vnmvekgiid ptkvvrtall daagvasllt
      541 taeavvteip keekdpgmga mggmgggmgg gmf
//
LOCUS       NP_001186277             429 aa            linear   ROD 27-AUG-2025
DEFINITION  forkhead box protein P3 [Mus musculus].
ACCESSION   NP_001186277
VERSION     NP_001186277.1
DBSOURCE    REFSEQ: accession NM_001199348.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 429)
  AUTHORS   Pignata,A., Frieser,D., Gonzalez-Fierro,C., Hsiao,C.C.,
            Engelenburg,H.J., Alis,M., Fijalkow,I., Cazaentre,V., Nozeran,L.,
            Miranda-Capet,R., Dufourd,E., Vermeulen,T., Aida,A., Le Coz,C., Van
            Gisbergen,K., Blanchard,N., Hamann,J., Smolders,J., Liblau,R.S. and
            Masson,F.
  TITLE     Tissue-resident memory CD4+ T cells infiltrate the CNS in
            progressive multiple sclerosis and contribute to chronic
            autoimmunity in mice
  JOURNAL   Sci Transl Med 17 (808), eadp8109 (2025)
   PUBMED   40700520
REFERENCE   2  (residues 1 to 429)
  AUTHORS   Kohne,M., Shakiba,M.H., Schmidleithner,L., Schulte-Schrepping,J.,
            Scholz,R., Elmzzahi,T., Sommer,D., Li,Y., Carraro,C., De
            Domenico,E., Wissfeld,J., Handler,K., Hamada,D., Frolov,A.,
            Cheng,X., Baumgart,A.K., Holsten,L., Osei-Sarpong,C., Bourry,S.,
            Thabet,Y., Renken,H., Paulusch,S., Sadlon,T., Buch,T.,
            Wunderlich,F.T., Wickenhauser,C., Alferink,J., Kuhlmann,T.,
            Geyer,M., Bonaguro,L., Barry,S.C., Schultze,J.L. and Beyer,M.D.
  TITLE     Satb1 directs the differentiation of TH17 cells through suppression
            of IL-2 expression
  JOURNAL   Cell Rep 44 (7), 115866 (2025)
   PUBMED   40531625
REFERENCE   3  (residues 1 to 429)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 429)
  AUTHORS   Huang,M., Wang,D., Huang,J., Bae,A.N., Xia,Y., Zhao,X., Mortaja,M.,
            Azin,M., Collier,M.R., Semenov,Y.R., Park,J.H. and Demehri,S.
  TITLE     Hepatitis B virus promotes liver cancer by modulating the immune
            response to environmental carcinogens
  JOURNAL   Nat Commun 16 (1), 5360 (2025)
   PUBMED   40579434
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 429)
  AUTHORS   Manrique-Rincon,A.J., Foster,B., Horswell,S., Goulding,D.A.,
            Adams,D.J. and Speak,A.O.
  TITLE     Simulating CD8 T cell exhaustion: A comprehensive approach
  JOURNAL   iScience 28 (7), 112897 (2025)
   PUBMED   40678524
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 429)
  AUTHORS   Blair,P.J., Bultman,S.J., Haas,J.C., Rouse,B.T., Wilkinson,J.E. and
            Godfrey,V.L.
  TITLE     CD4+CD8- T cells are the effector cells in disease pathogenesis in
            the scurfy (sf) mouse
  JOURNAL   J Immunol 153 (8), 3764-3774 (1994)
   PUBMED   7930593
REFERENCE   7  (residues 1 to 429)
  AUTHORS   Blair,P.J., Carpenter,D.A., Godfrey,V.L., Russell,L.B.,
            Wilkinson,J.E. and Rinchik,E.M.
  TITLE     The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3
            on the proximal X chromosome
  JOURNAL   Mamm Genome 5 (10), 652-654 (1994)
   PUBMED   7849405
REFERENCE   8  (residues 1 to 429)
  AUTHORS   Godfrey,V.L., Rouse,B.T. and Wilkinson,J.E.
  TITLE     Transplantation of T cell-mediated, lymphoreticular disease from
            the scurfy (sf) mouse
  JOURNAL   Am J Pathol 145 (2), 281-286 (1994)
   PUBMED   8053488
REFERENCE   9  (residues 1 to 429)
  AUTHORS   Godfrey,V.L., Wilkinson,J.E. and Russell,L.B.
  TITLE     X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
  JOURNAL   Am J Pathol 138 (6), 1379-1387 (1991)
   PUBMED   2053595
REFERENCE   10 (residues 1 to 429)
  AUTHORS   Lyon,M.F., Peters,J., Glenister,P.H., Ball,S. and Wright,E.
  TITLE     The scurfy mouse mutant has previously unrecognized hematological
            abnormalities and resembles Wiskott-Aldrich syndrome
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2433-2437 (1990)
   PUBMED   2320565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731793.18 and AL672231.7.
            
            Summary: The protein encoded by this gene is a member of the
            forkhead/winged-helix family of transcriptional regulators. Defects
            in this gene result in the scurfy phenotype (sf). Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.41 cM"
     Protein         1..429
                     /product="forkhead box protein P3"
                     /note="scurfy"
                     /calculated_mol_wt=47216
     mat_peptide     1..417
                     /product="Forkhead box protein P3, C-terminally processed.
                     /evidence=ECO:0000305|PubMed:19117830. /id=PRO_0000432436"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
                     /calculated_mol_wt=46034
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000269|PubMed:23853094; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            31
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            51..52
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:19117830;
                     propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     mat_peptide     52..417
                     /product="Forkhead box protein P3 41 kDa form.
                     /evidence=ECO:0000305|PubMed:19117830. /id=PRO_0000432437"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
                     /calculated_mol_wt=40815
     Region          67..75
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          91..95
                     /region_name="LXXLL motif.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          105..189
                     /region_name="Essential for transcriptional repressor
                     activity and for interaction with KAT5 and HDAC7.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          148..198
                     /region_name="Interaction with IKZF4.
                     /evidence=ECO:0000269|PubMed:19696312"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK2.
                     /evidence=ECO:0000269|PubMed:23853094; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          192..259
                     /region_name="FOXP-CC"
                     /note="FOXP coiled-coil domain; pfam16159"
                     /db_xref="CDD:465036"
     Region          238..259
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          238..247
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            262
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            267
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          277..336
                     /region_name="Interaction with RUNX1.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          337..417
                     /region_name="FH_FOXP3"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     P3 (FOXP3) and similar proteins; cd20066"
                     /db_xref="CDD:410840"
     Site            order(337..338,340,342..343,345..348,350..352,357..360,
                     363..374,377..378,381..382,384..386,388..389,395,400..402,
                     405..408,410,413,415..417)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:410840"
     Site            order(341..342,360..361,364,378,380,383,386..387,390,397,
                     404,406)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410840"
     Region          414..417
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            417..418
                     /site_type="cleavage"
                     /note="Cleavage, by PCSK1 or PCSK2.
                     /evidence=ECO:0000269|PubMed:19117830; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     CDS             1..429
                     /gene="Foxp3"
                     /gene_synonym="JM2; scurfin; sf"
                     /coded_by="NM_001199348.2:195..1484"
                     /db_xref="CCDS:CCDS29965.1"
                     /db_xref="GeneID:20371"
                     /db_xref="MGI:MGI:1891436"
ORIGIN      
        1 mpnprpakpm apslalgpsp gvlpswktap kgsellgtrg sggpfqgrdl rsgahtsssl
       61 nplppsqlql ptvplvmvap sgarlgpsph lqallqdrph fmhqlstvda haqtpvlqvr
      121 pldnpamisl pppsaatgvf slkarpglpp ginvaslewv srepallctf prsgtprkds
      181 nllaapqgsy pllangvckw pgcekvfeep eeflkhcqad hlldekgkaq cllqrevvqs
      241 leqqleleke klgamqahla gkmalakaps vasmdksscc ivatstqgsv lpawsaprea
      301 pdgglfavrr hlwgshgnss fpeffhnmdy fkyhnmrppf tyatlirwai leaperqrtl
      361 neiyhwftrm fayfrnhpat wknairhnls lhkcfvrves ekgavwtvde fefrkkrsqr
      421 pnkcsnpcp
//
LOCUS       NP_001361648             593 aa            linear   ROD 27-AUG-2025
DEFINITION  fragile X messenger ribonucleoprotein 1 isoform 3 [Mus musculus].
ACCESSION   NP_001361648 XP_006527874
VERSION     NP_001361648.1
DBSOURCE    REFSEQ: accession NM_001374719.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 593)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 593)
  AUTHORS   Wang,Z.H., Xu,C., Ma,Y.Y., Xue,W.X., Wang,H.Y., Fan,L.Y.,
            Zhang,C.Y., Li,L., Zhang,X.Y., Zhu,J.N. and Zhang,Q.P.
  TITLE     Oxytocin Improves Autistic Behaviors by Positively Shifting GABA
            Reversal Potential via NKCC1 in Early-Postnatal-Stage
  JOURNAL   Adv Sci (Weinh) 12 (21), e2415432 (2025)
   PUBMED   40305761
REFERENCE   3  (residues 1 to 593)
  AUTHORS   Jing,P.B., Zhou,Y.W., Zhang,F.M., Ge,J.Y., Wu,J.N., Xu,J.H.,
            Cao,X.H., Chang,N., Zhou,X., Luo,L. and Liu,X.J.
  TITLE     Autistic-like behaviors and impaired chronic inflammatory pain in
            primary nociceptive neuron-specific deletion of Mecp2 or Fmr1
            knockout male mice
  JOURNAL   Behav Brain Res 486, 115570 (2025)
   PUBMED   40174753
REFERENCE   4  (residues 1 to 593)
  AUTHORS   Lee,Y., Ishikawa,T., Lee,H., Lee,B., Ryu,C., Davila Mejia,I.,
            Kim,M., Lu,G., Hong,Y., Feng,M., Shin,H., Meloche,S.,
            Locksley,R.M., Koltsova,E., Grivennikov,S.I., Heiman,M., Choi,G.B.
            and Huh,J.R.
  TITLE     Brain-wide mapping of immune receptors uncovers a neuromodulatory
            role of IL-17E and the receptor IL-17RB
  JOURNAL   Cell 188 (8), 2203-2217 (2025)
   PUBMED   40199322
REFERENCE   5  (residues 1 to 593)
  AUTHORS   Hooshmandi,M., Ho-Tieng,D., Lister,K.C., Cai,W., Wong,C., Brown,N.,
            Fan,J., Hovhannisyan,V., Uttam,S., Prager-Khoutorsky,M.,
            Sonenberg,N., Gkogkas,C.G. and Khoutorsky,A.
  TITLE     Postnatal downregulation of Fmr1 in microglia promotes microglial
            reactivity and causes behavioural alterations in female mice
  JOURNAL   Mol Autism 16 (1), 17 (2025)
   PUBMED   40055803
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 593)
  AUTHORS   Verheij,C., de Graaff,E., Bakker,C.E., Willemsen,R., Willems,P.J.,
            Meijer,N., Galjaard,H., Reuser,A.J., Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Characterization of FMR1 proteins isolated from different tissues
  JOURNAL   Hum Mol Genet 4 (5), 895-901 (1995)
   PUBMED   7633450
REFERENCE   7  (residues 1 to 593)
  AUTHORS   Khandjian,E.W., Fortin,A., Thibodeau,A., Tremblay,S., Cote,F.,
            Devys,D., Mandel,J.L. and Rousseau,F.
  TITLE     A heterogeneous set of FMR1 proteins is widely distributed in mouse
            tissues and is modulated in cell culture
  JOURNAL   Hum Mol Genet 4 (5), 783-789 (1995)
   PUBMED   7633436
REFERENCE   8  (residues 1 to 593)
  AUTHORS   Laval,S.H., Blair,H.J., Hirst,M.C., Davies,K.E. and Boyd,Y.
  TITLE     Mapping of FMR1, the gene implicated in fragile X-linked mental
            retardation, on the mouse X chromosome
  JOURNAL   Genomics 12 (4), 818-821 (1992)
   PUBMED   1572655
REFERENCE   9  (residues 1 to 593)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (residues 1 to 593)
  AUTHORS   Mandel,J.L., Arveiler,B., Camerino,G., Hanauer,A., Heilig,R.,
            Koenig,M. and Oberle,I.
  TITLE     Genetic mapping of the human X chromosome: linkage analysis of the
            q26-q28 region that includes the fragile X locus and isolation of
            expressed sequences
  JOURNAL   Cold Spring Harb Symp Quant Biol 51 Pt 1, 195-203 (1986)
   PUBMED   3472716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055766.31.
            
            On Oct 10, 2019 this sequence version replaced XP_006527874.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.4880.1,
                                           ERR3363660.2768390.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.83 cM"
     Protein         1..593
                     /product="fragile X messenger ribonucleoprotein 1 isoform
                     3"
                     /note="FMRP translational regulator 1; synaptic functional
                     regulator FMR1"
                     /calculated_mol_wt=66587
     Region          1..55
                     /region_name="Tudor_Agenet_FMR1_rpt1"
                     /note="first Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20471"
                     /db_xref="CDD:410542"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410542"
     Region          58..120
                     /region_name="Tudor_Agenet_FMR1_rpt2"
                     /note="second Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20474"
                     /db_xref="CDD:410545"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410545"
     Region          123..199
                     /region_name="KH_I_FMR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22506"
                     /db_xref="CDD:411934"
     Region          218..280
                     /region_name="KH_I_FMR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22509"
                     /db_xref="CDD:411937"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411937"
     Region          281..402
                     /region_name="KH_I_FMR1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22512"
                     /db_xref="CDD:411940"
     Site            order(290..294,297,300..301,305,308..309,312..323,325)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:411940"
     Site            order(291,293..295,297..301,304..305,308..309,315..318)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411940"
     Region          398..503
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:463501"
     Region          528..593
                     /region_name="FXMR_C2"
                     /note="Fragile X-related mental retardation protein
                     C-terminal region 2; pfam16098"
                     /db_xref="CDD:465020"
     CDS             1..593
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /coded_by="NM_001374719.1:236..2017"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS90720.1"
                     /db_xref="GeneID:14265"
                     /db_xref="MGI:MGI:95564"
ORIGIN      
        1 meelvvevrg sngafykafv kdvhedsitv afennwqper qipfhdvrfp ppvgynkdin
       61 esdevevysr anekepccww lakvrmikge fyvieyaacd atyneivtie rlrsvnpnkp
      121 atkdtfhkik levpedlrqm cakesahkdf kkavgafsvt ydpenyqlvi lsinevtskr
      181 ahmlidmhfr slrtklslil rneeaskqle ssrqlasrfh eqfivredlm glaigthgan
      241 iqqarkvpgv taidldedtc tfhiygedqd avkkarsfle faedviqvpr nlvgkvigkn
      301 gkliqeivdk sgvvrvriea eneksvpqee eimppsslps nnsrvgpnss eekkhldtke
      361 nthfsqpnst kvqrgmvpfv fvgtkdsian atvlldyhln ylkevdqlrl erlqideqlr
      421 qigassrppp nrtdkekgyv tddgqgmgrg srpyrnrghg rrgpgytsgt nseasnaset
      481 esdhrdelsd wslapteeer esflrrgdgr rrggggrgqg grgrgggfkg nddhsrtdnr
      541 prnpreakgr tadgslqsas segsrlrtgk drnqkkekpd svdglqplvn gvp
//
LOCUS       NP_001399533             314 aa            linear   ROD 27-AUG-2025
DEFINITION  ATP-sensitive inward rectifier potassium channel 11 isoform 3
            precursor [Mus musculus].
ACCESSION   NP_001399533 XP_006540726
VERSION     NP_001399533.1
DBSOURCE    REFSEQ: accession NM_001412604.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 314)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 314)
  AUTHORS   Stokum,J.A., Shim,B., Negoita,S., Tsymbalyuk,N., Tsymbalyuk,O.,
            Ivanova,S., Keledjian,K., Bryan,J., Blaustein,M.P., Jha,R.M.,
            Kahle,K.T., Gerzanich,V. and Simard,J.M.
  TITLE     Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet
            induces water influx through AQP4 and brain swelling after ischemic
            stroke
  JOURNAL   Sci Signal 16 (788), eadd6364 (2023)
   PUBMED   37279286
REFERENCE   4  (residues 1 to 314)
  AUTHORS   Grizzanti,J., Moritz,W.R., Pait,M.C., Stanley,M., Kaye,S.D.,
            Carroll,C.M., Constantino,N.J., Deitelzweig,L.J., Snipes,J.A.,
            Kellar,D., Caesar,E.E., Pettit-Mee,R.J., Day,S.M., Sens,J.P.,
            Nicol,N.I., Dhillon,J., Remedi,M.S., Kiraly,D.D., Karch,C.M.,
            Nichols,C.G., Holtzman,D.M. and Macauley,S.L.
  TITLE     KATP channels are necessary for glucose-dependent increases in
            amyloid-beta and Alzheimer's disease-related pathology
  JOURNAL   JCI Insight 8 (10), e162454 (2023)
   PUBMED   37129980
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 314)
  AUTHORS   Gong,Y., Laheji,F., Berenson,A., Qian,A., Park,S.O., Kok,R.,
            Selig,M., Hahn,R., Sadjadi,R., Kemp,S. and Eichler,F.
  TITLE     Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical
            Allodynia
  JOURNAL   Cells 11 (11), 1842 (2022)
   PUBMED   35681537
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 314)
  AUTHORS   Suzuki,M., Fujikura,K., Inagaki,N., Seino,S. and Takata,K.
  TITLE     Localization of the ATP-sensitive K+ channel subunit Kir6.2 in
            mouse pancreas
  JOURNAL   Diabetes 46 (9), 1440-1444 (1997)
   PUBMED   9287044
REFERENCE   7  (residues 1 to 314)
  AUTHORS   Yamada,M., Isomoto,S., Matsumoto,S., Kondo,C., Shindo,T., Horio,Y.
            and Kurachi,Y.
  TITLE     Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive
            but ATP-insensitive K+ channel
  JOURNAL   J Physiol 499 (Pt 3) (Pt 3), 715-720 (1997)
   PUBMED   9130167
REFERENCE   8  (residues 1 to 314)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P., Wang,C.Z., Aguilar-Bryan,L.,
            Bryan,J. and Seino,S.
  TITLE     A family of sulfonylurea receptors determines the pharmacological
            properties of ATP-sensitive K+ channels
  JOURNAL   Neuron 16 (5), 1011-1017 (1996)
   PUBMED   8630239
REFERENCE   9  (residues 1 to 314)
  AUTHORS   Sakura,H., Ammala,C., Smith,P.A., Gribble,F.M. and Ashcroft,F.M.
  TITLE     Cloning and functional expression of the cDNA encoding a novel
            ATP-sensitive potassium channel subunit expressed in pancreatic
            beta-cells, brain, heart and skeletal muscle
  JOURNAL   FEBS Lett 377 (3), 338-344 (1995)
   PUBMED   8549751
REFERENCE   10 (residues 1 to 314)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115036.10.
            
            On Oct 12, 2022 this sequence version replaced XP_006540726.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2761416.1,
                                           SRR17784643.1524916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     Protein         1..314
                     /product="ATP-sensitive inward rectifier potassium channel
                     11 isoform 3 precursor"
                     /note="ATP-sensitive inward rectifier potassium channel
                     11; inward rectifier K(+) channel Kir6.2"
                     /calculated_mol_wt=31940
     Region          <1..98
                     /region_name="IRK"
                     /note="Inward rectifier potassium channel transmembrane
                     domain; pfam01007"
                     /db_xref="CDD:460023"
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2630
     Region          105..278
                     /region_name="IRK_C"
                     /note="Inward rectifier potassium channel C-terminal
                     domain; pfam17655"
                     /db_xref="CDD:465439"
     CDS             1..314
                     /gene="Kcnj11"
                     /gene_synonym="Kir6.2; mBIR"
                     /coded_by="NM_001412604.1:378..1322"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="GeneID:16514"
                     /db_xref="MGI:MGI:107501"
ORIGIN      
        1 msflcswllf amvwwliafa hgdlapgegt nvpcvtsihs fssaflfsie vqvtigfggr
       61 mvteecplai lilivqnivg lminaimlgc ifmktaqahr raetlifskh avitlrhgrl
      121 cfmlrvgdlr ksmiisatih mqvvrkttsp egevvplhqv dipmengvgg ngiflvapli
      181 iyhvidsnsp lydlapsdlh hhqdleiivi legvvettgi ttqartsyla deilwgqrfv
      241 pivaeedgry svdyskfgnt ikvptplcta rqldedrsll daltlassrg plrkrsvava
      301 kakpkfsisp dsls
//
LOCUS       NP_001157159             360 aa            linear   ROD 27-AUG-2025
DEFINITION  N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
            [Mus musculus].
ACCESSION   NP_001157159
VERSION     NP_001157159.1
DBSOURCE    REFSEQ: accession NM_001163687.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Fotio,Y., Mabou Tagne,A., Squire,E., Lee,H.L., Phillips,C.M.,
            Chang,K., Ahmed,F., Greenberg,A.S., Villalta,S.A., Scarfone,V.M.,
            Spadoni,G., Mor,M. and Piomelli,D.
  TITLE     NAAA-regulated lipid signaling in monocytes controls the induction
            of hyperalgesic priming in mice
  JOURNAL   Nat Commun 15 (1), 1705 (2024)
   PUBMED   38402219
  REMARK    GeneRIF: NAAA-regulated lipid signaling in monocytes controls the
            induction of hyperalgesic priming in mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Li,Y., Li,Y., Xu,S., Chen,Y., Zhou,P., Hu,T., Li,H., Liu,Y., Xu,Y.,
            Ren,J., Qiu,Y. and Lu,C.
  TITLE     N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis
            inflammation by enhancing dendritic cell (DCs) maturation
  JOURNAL   Pharmacol Res 185, 106491 (2022)
   PUBMED   36244543
  REMARK    Erratum:[Pharmacol Res. 2022 Nov;185:106527. doi:
            10.1016/j.phrs.2022.106527. PMID: 36328902]
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Palese,F., Pontis,S., Realini,N., Torrens,A., Ahmed,F., Assogna,F.,
            Pellicano,C., Bossu,P., Spalletta,G., Green,K. and Piomelli,D.
  TITLE     Targeting NAAA counters dopamine neuron loss and symptom
            progression in mouse models of parkinsonism
  JOURNAL   Pharmacol Res 182, 106338 (2022)
   PUBMED   35781057
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Xie,X., Li,Y., Xu,S., Zhou,P., Yang,L., Xu,Y., Qiu,Y., Yang,Y. and
            Li,Y.
  TITLE     Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid
            Ethanolamides (FAEs) Metabolism and Inflammatory Responses
  JOURNAL   Front Pharmacol 12, 817603 (2022)
   PUBMED   35069223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Alhouayek,M., Bottemanne,P., Subramanian,K.V., Lambert,D.M.,
            Makriyannis,A., Cani,P.D. and Muccioli,G.G.
  TITLE     N-Acylethanolamine-hydrolyzing acid amidase inhibition increases
            colon N-palmitoylethanolamine levels and counteracts murine colitis
  JOURNAL   FASEB J 29 (2), 650-661 (2015)
   PUBMED   25384424
  REMARK    GeneRIF: NAAA inhibition increases palmitoylethanolamide levels in
            the colon and reduces colon inflammation and systemic inflammation
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Sasso,O., Moreno-Sanz,G., Martucci,C., Realini,N., Dionisi,M.,
            Mengatto,L., Duranti,A., Tarozzo,G., Tarzia,G., Mor,M.,
            Bertorelli,R., Reggiani,A. and Piomelli,D.
  TITLE     Antinociceptive effects of the N-acylethanolamine acid amidase
            inhibitor ARN077 in rodent pain models
  JOURNAL   Pain 154 (3), 350-360 (2013)
   PUBMED   23218523
  REMARK    GeneRIF: NAAA regulates peripheral pain initiation by interrupting
            endogenous fatty acid ethanolamide signaling at PPAR-alpha.
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Zhao,L.Y., Tsuboi,K., Okamoto,Y., Nagahata,S. and Ueda,N.
  TITLE     Proteolytic activation and glycosylation of
            N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme
            involved in the endocannabinoid metabolism
  JOURNAL   Biochim Biophys Acta 1771 (11), 1397-1405 (2007)
   PUBMED   17980170
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Sun,Y.X., Tsuboi,K., Zhao,L.Y., Okamoto,Y., Lambert,D.M. and
            Ueda,N.
  TITLE     Involvement of N-acylethanolamine-hydrolyzing acid amidase in the
            degradation of anandamide and other N-acylethanolamines in
            macrophages
  JOURNAL   Biochim Biophys Acta 1736 (3), 211-220 (2005)
   PUBMED   16154384
  REMARK    GeneRIF: Results suggest that N-acylethanolamine-hydrolyzing acid
            amidase and fatty acid amide hydrolase cooperatively degrade
            anandamide and other N-acylethanolamines in macrophages.
REFERENCE   10 (residues 1 to 360)
  AUTHORS   Tsuboi,K., Sun,Y.X., Okamoto,Y., Araki,N., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of N-acylethanolamine-hydrolyzing acid
            amidase, a novel member of the choloylglycine hydrolase family with
            structural and functional similarity to acid ceramidase
  JOURNAL   J Biol Chem 280 (12), 11082-11092 (2005)
   PUBMED   15655246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008776.1, AK017141.1, AC125542.4 and AK133485.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter isoform (2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017141.1, SRR7345562.3176807.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.35 cM"
     Protein         1..360
                     /product="N-acylethanolamine-hydrolyzing acid amidase
                     isoform 2 precursor"
                     /EC_number="3.5.1.23"
                     /EC_number="3.5.1.60"
                     /note="N-acylethanolamine-hydrolyzing acid amidase;
                     ASAH-like protein; acylsphingosine deacylase NAAA"
                     /calculated_mol_wt=36663
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3159
     Region          36..94
                     /region_name="NAAA-beta"
                     /note="beta subunit of N-acylethanolamine-hydrolyzing acid
                     amidase; pfam15508"
                     /db_xref="CDD:464754"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30301806,
                     ECO:0007744|PDB:6DXY; propagated from UniProtKB/Swiss-Prot
                     (Q9D7V9.2)"
     Site            110
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Region          120..349
                     /region_name="Ntn_AC_NAAA"
                     /note="AC_NAAA This conserved domain includes two closely
                     related proteins, acid ceramidase (AC, also known as
                     N-acylsphingosine amidohydrolase), and
                     N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC
                     catalyzes the hydrolysis of ceramide to sphingosine
                     and...; cd01903"
                     /db_xref="CDD:238886"
     Site            145
                     /site_type="other"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000250|UniProtKB:Q02083; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Site            290
                     /site_type="other"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000250|UniProtKB:Q02083; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Site            312
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30301806,
                     ECO:0007744|PDB:6DXY; propagated from UniProtKB/Swiss-Prot
                     (Q9D7V9.2)"
     Site            336
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     CDS             1..360
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /coded_by="NM_001163687.1:50..1132"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS51545.1"
                     /db_xref="GeneID:67111"
                     /db_xref="MGI:MGI:1914361"
ORIGIN      
        1 mgtlatraac hgahlalall lllslsgpwl savvpgtppl fnvsldaape qrwlpmlrhy
       61 dpdflrtava qvigvpqwvl gmvgeivskv esflpqpftd eirsicdsln lsladgilvn
      121 layeasafct sivaqdsqgh iyhgrnldyp fgkilrklta nvqfikngqi aftgttfvgy
      181 vglwtgqsph kftisgderd kgwwwenmia alslghspis wlirktlses esfeaavytl
      241 aktpliadvy yivggtspke gvvitrdrgg padiwpldpl ngewfrvetn ydhwkpapkv
      301 ddrrtpaika lnatgqahln letlfqvlsl fpvynnytiy ttvmsaaepd kyltmirnps
//
LOCUS       NP_001395644             136 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 8
            [Mus musculus].
ACCESSION   NP_001395644
VERSION     NP_001395644.1
DBSOURCE    REFSEQ: accession NM_001408715.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 136)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 136)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 136)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 136)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 136)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 136)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 136)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 136)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 136)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 136)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345558.267474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..136
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..136
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 8"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=15652
     Region          27..121
                     /region_name="PWWP"
                     /note="PWWP (Pro-Trp-Trp-Pro) domain; cl02554"
                     /db_xref="CDD:470613"
     Site            order(43,46,77)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438958"
     Site            44..47
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438958"
     CDS             1..136
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408715.1:226..636"
                     /note="isoform 8 is encoded by transcript variant 19"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mleipgtssp stsqelpfcq pkkkstplky evgdliwakf krrpwwpcri csdplinths
       61 kmkvanrrpy reyyveafgd psekawvagk aivmfegrhq feelpvlrkr gkqkekgyrh
      121 ktgflcvala vleltl
//
LOCUS       NP_001396739             751 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 3 [Mus musculus].
ACCESSION   NP_001396739 XP_006505584
VERSION     NP_001396739.1
DBSOURCE    REFSEQ: accession NM_001409810.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 22, 2022 this sequence version replaced XP_006505584.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4337215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..751
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     3"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85789
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          334..527
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          345..431
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            371
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            372
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          564..595
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          614..733
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(618,620..623,625,629,632,634,684..685,688,708,724)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(626..629,646,653,656..657,660,664,667..673,690..694,
                     702,729,731..732)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..694,731)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..693)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(646,653,656..657,660,664,669,671..673,702,729,
                     731..733)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..751
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409810.1:219..2474"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhrkc
      301 sysfhatpnt ykrkntetal dnkpcgpqcy qhlegakefa aaltaerikt ppkrpggrrr
      361 grlpnnssrp stptisvles kdtdsdreag tetggenndk eeeekkdets ssseansrcq
      421 tpikmkpnie ppenvewsga easmfrvlig tyydnfcaia rligtktcrq vyefrvkess
      481 iiapvptedv dtpprkkkrk hrlwaahcrk iqlkkdgssn hvynyqpcdh prqpcdsscp
      541 cviaqnfcek fcqcssecqn rfpgcrckaq cntkqcpcyl avrecdpdlc ltcgaadhwd
      601 sknvsckncs iqrgskkhll lapsdvagwg ifikdpvqkn efiseycgei isqdeadrrg
      661 kvydkymcsf lfnlnndfvv datrkgnkir fanhsvnpnc yakvmmvngd hrigifakra
      721 iqtgeelffd yrysqadalk yvgieremei p
//
LOCUS       NP_001405744             113 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 11 [Mus musculus].
ACCESSION   NP_001405744 XP_006526292
VERSION     NP_001405744.1
DBSOURCE    REFSEQ: accession NM_001418815.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 113)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 113)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 113)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 113)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 113)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 113)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 113)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 113)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 113)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 113)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            On Mar 23, 2023 this sequence version replaced XP_006526292.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.977849.1,
                                           SRR7345562.3562540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..113
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..113
                     /product="COMM domain-containing protein 10 isoform 11"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=12489
     Region          15..112
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..113
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418815.1:39..380"
                     /note="isoform 11 is encoded by transcript variant 11"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 maasaalilp espsmkkavp linaidtgrf prllsrilqk lhlkletvgw qlnlqmahsa
       61 qaklqspqav lqlgvskeda knvekvlvef nhkelfdfyn kletiqaqld slt
//
LOCUS       NP_001405935             333 aa            linear   ROD 27-AUG-2025
DEFINITION  low affinity immunoglobulin gamma Fc region receptor II-b isoform 3
            [Mus musculus].
ACCESSION   NP_001405935
VERSION     NP_001405935.1
DBSOURCE    REFSEQ: accession NM_001419006.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Bennion,K.B., Miranda R Bazzano,J., Liu,D., Wagener,M., Paulos,C.M.
            and Ford,M.L.
  TITLE     Macrophage-derived Fgl2 dampens antitumor immunity through
            regulation of FcgammaRIIB+CD8+ T cells in melanoma
  JOURNAL   JCI Insight 10 (6), e182563 (2025)
   PUBMED   40125553
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Santana,S., Papillion,A., Foote,J.B., Bachus,H., Leon,B., De
            Miguel,C. and Ballesteros-Tato,A.
  TITLE     Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents
            Autoantibody Responses in Systemic Lupus Erythematosus via
            Regulatory T Cell-independent Depletion of T Follicular Helper
            Cells
  JOURNAL   J Immunol 213 (8), 1053-1060 (2024)
   PUBMED   39195194
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Dickles,H.B., Ahmed,A. and Sachs,D.H.
  TITLE     B-lymphocyte Fc receptor-associated non-H-2 antigens are determined
            by a single polymorphic locus which is linked to the Mls locus
  JOURNAL   J Exp Med 146 (6), 1678-1692 (1977)
   PUBMED   303687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115959.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.491400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.02 cM"
     Protein         1..333
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b isoform 3"
                     /note="low affinity immunoglobulin gamma Fc region
                     receptor II; fc-gamma RII; fc-gamma-RIIB; fc gamma
                     receptor IIB; lymphocyte antigen 17; igG Fc receptor II
                     beta; Fc-gamma-RII; Fc gamma RIIB; FcgammaRIIB; low
                     affinity immunoglobulin gamma Fc region receptor II-b"
                     /calculated_mol_wt=36994
     Region          39..117
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          56..60
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409410"
     Region          70..74
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409410"
     Region          85..89
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409410"
     Region          99..104
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409410"
     Region          110..113
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409410"
     Region          121..203
                     /region_name="Ig2_FcgammaR_like"
                     /note="Second immunoglobulin (Ig)-like domain of
                     Fcgamma-receptors (FcgammaRs), and similar domains;
                     cd05753"
                     /db_xref="CDD:409411"
     Site            order(121,144,150..151)
                     /site_type="other"
                     /note="Fc binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          121..125
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409411"
     Region          130..132
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409411"
     Site            order(134..136,145,150,189)
                     /site_type="other"
                     /note="pentraxin binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          136..143
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409411"
     Region          150..156
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409411"
     Region          159..164
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409411"
     Region          168..172
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409411"
     Region          182..187
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409411"
     Region          193..203
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409411"
     CDS             1..333
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /coded_by="NM_001419006.1:81..1082"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="GeneID:14130"
                     /db_xref="MGI:MGI:95499"
ORIGIN      
        1 mgilpfllip mesnwtvhvf srtlchmllw tavlnlpkav vkleppwiqv lkedtvtltc
       61 egthnpgnss tqwfhngrsi rsqvqasytf katvndsgey rcqmeqtrls dpvdlgvisd
      121 wlllqtpqlv flegetitlr chswrnklln risffhneks vryhhyssnf sipkanhshs
      181 gdyyckgslg rtlhqskpvt itvqgpkssr slpvltivaa vtgiavaaiv iilvslvylk
      241 kkqvpalpgn pdhremgetl peevgeyrqp sggsvpvspg ppsgleptss spynppdlee
      301 aakteaenti tysllkhpea ldeetehdyq nhi
//
LOCUS       NP_033241                116 aa            linear   ROD 27-AUG-2025
DEFINITION  somatostatin precursor [Mus musculus].
ACCESSION   NP_033241
VERSION     NP_033241.1
DBSOURCE    REFSEQ: accession NM_009215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 116)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 116)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 116)
  AUTHORS   Zhao,M., Zhang,L., Chen,Z., Zhang,S., Cheng,X., Huang,M., Li,X.,
            Gu,H., Guan,X., Geng,D., Li,Y., Tu,Y., Xie,Z., Zhang,F., Ma,H.,
            Li,X., Li,D., Wu,Q.F. and Cao,P.
  TITLE     A molecularly defined brain circuit module for regulating
            panic-like defensive state
  JOURNAL   Nat Commun 16 (1), 5523 (2025)
   PUBMED   40595505
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 116)
  AUTHORS   Garcia,M.M., Kline,A.M., Onodera,K., Tsukano,H., Dandu,P.R.,
            Acosta,H.C., Kasten,M.R., Manis,P.B. and Kato,H.K.
  TITLE     Noncanonical short-latency auditory pathway directly activates deep
            cortical layers
  JOURNAL   Nat Commun 16 (1), 5911 (2025)
   PUBMED   40593664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 116)
  AUTHORS   Grady,F.S., Graff,S.A., Warnock,M.M., Gasparini,S., Tish,M.M.,
            Li,Y., Buchanan,G.F., Resch,J.M. and Geerling,J.C.
  TITLE     Parabrachial Foxp2-expressing neurons are necessary for sustaining
            core body temperature in the cold
  JOURNAL   iScience 28 (8), 112764 (2025)
   PUBMED   40703448
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 116)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   7  (residues 1 to 116)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (residues 1 to 116)
  AUTHORS   Yasue,M., Serikawa,T., Kuramoto,T., Mori,M., Higashiguchi,T.,
            Ishizaki,K. and Yamada,J.
  TITLE     Chromosomal assignments of 17 structural genes and 11 related DNA
            fragments in rats (Rattus norvegicus) by Southern blot analysis of
            rat x mouse somatic cell hybrid clones
  JOURNAL   Genomics 12 (4), 659-664 (1992)
   PUBMED   1572638
REFERENCE   9  (residues 1 to 116)
  AUTHORS   Gittes,G.K. and Rutter,W.J.
  TITLE     Onset of cell-specific gene expression in the developing mouse
            pancreas
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 1128-1132 (1992)
   PUBMED   1371010
REFERENCE   10 (residues 1 to 116)
  AUTHORS   Iwasaki,Y., Ohkubo,A., Kamei,S. and Kosaka,K.
  TITLE     [Serial determination of serum GOT isozyme activities for the
            evaluation of acute hepatic damage (author's transl)]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 75 (1), 34-43 (1978)
   PUBMED   642215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127241.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703452.1, AK003014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..116
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 15.0 cM"
     Protein         1..116
                     /product="somatostatin precursor"
                     /note="preprosomatostatin"
                     /calculated_mol_wt=10387
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2377
     Site            43
                     /site_type="amidation"
                     /note="Threonine amide.
                     /evidence=ECO:0000250|UniProtKB:P60042; propagated from
                     UniProtKB/Swiss-Prot (P60041.1)"
     Region          99..116
                     /region_name="Somatostatin"
                     /note="Somatostatin/Cortistatin family; pfam03002"
                     /db_xref="CDD:367290"
     CDS             1..116
                     /gene="Sst"
                     /gene_synonym="Smst; SOM; SRIF; SS"
                     /coded_by="NM_009215.2:101..451"
                     /db_xref="CCDS:CCDS28080.1"
                     /db_xref="GeneID:20604"
                     /db_xref="MGI:MGI:98326"
ORIGIN      
        1 mlscrlqcal aalcivlalg gvtgapsdpr lrqflqksla aatgkqelak yflaellsep
       61 nqtendalep edlpqaaeqd emrlelqrsa nsnpamapre rkagcknffw ktftsc
//
LOCUS       NP_035886                319 aa            linear   ROD 27-AUG-2025
DEFINITION  mRNA decay activator protein ZFP36 [Mus musculus].
ACCESSION   NP_035886
VERSION     NP_035886.1
DBSOURCE    REFSEQ: accession NM_011756.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 319)
  AUTHORS   Morel,K.L., German,B., Hamid,A.A., Nanda,J.S., Linder,S.,
            Bergman,A.M., van der Poel,H., Hofland,I., Bekers,E.M.,
            Trostel,S.Y., Burkhart,D.L., Wilkinson,S., Ku,A.T., Kim,M., Kim,J.,
            Ma,D., Plummer,J.T., You,S., Su,X.A., Zwart,W., Sowalsky,A.G.,
            Sweeney,C.J. and Ellis,L.
  TITLE     Low tristetraprolin expression activates phenotypic plasticity and
            primes transition to lethal prostate cancer in mice
  JOURNAL   J Clin Invest 135 (2), e175680 (2024)
   PUBMED   39560993
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 319)
  AUTHORS   Yadav,S., El Hamra,R., Alturki,N.A., Ariana,A., Bhan,A., Hurley,K.,
            Gaestel,M., Blackshear,P.J., Blais,A. and Sad,S.
  TITLE     Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of
            inflammatory cytokines during necroptosis stimulation
  JOURNAL   Cell Death Dis 15 (8), 574 (2024)
   PUBMED   39117638
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 319)
  AUTHORS   Rong,S., Li,H., Wei,Y., Feng,Z., Gan,L., Deng,Z. and Zhao,L.
  TITLE     [Zinc finger protein-36 deficiency inhibits osteogenic
            differentiation of mouse bone marrow-derived mesenchymal stem cells
            and preosteoblasts by activating the ERK/MAPK pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (4), 697-705 (2024)
   PUBMED   38708503
  REMARK    GeneRIF: [Zinc finger protein-36 deficiency inhibits osteogenic
            differentiation of mouse bone marrow-derived mesenchymal stem cells
            and preosteoblasts by activating the ERK/MAPK pathway].
REFERENCE   4  (residues 1 to 319)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 319)
  AUTHORS   Yang,N., Zhang,Y., Ren,P., Zhao,L., Zheng,D., Fu,L. and Jin,J.
  TITLE     LncRNA AA465934 Improves Podocyte Injury by Promoting
            Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic
            Nephropathy
  JOURNAL   Mol Cell Biol 44 (3), 87-102 (2024)
   PUBMED   38520226
  REMARK    GeneRIF: LncRNA AA465934 Improves Podocyte Injury by Promoting
            Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic
            Nephropathy.
REFERENCE   6  (residues 1 to 319)
  AUTHORS   Ma,Q. and Herschman,H.R.
  TITLE     A corrected sequence for the predicted protein from the
            mitogen-inducible TIS11 primary response gene
  JOURNAL   Oncogene 6 (7), 1277-1278 (1991)
   PUBMED   1861870
REFERENCE   7  (residues 1 to 319)
  AUTHORS   Taylor,G.A., Lai,W.S., Oakey,R.J., Seldin,M.F., Shows,T.B.,
            Eddy,R.L. Jr. and Blackshear,P.J.
  TITLE     The human TTP protein: sequence, alignment with related proteins,
            and chromosomal localization of the mouse and human genes
  JOURNAL   Nucleic Acids Res 19 (12), 3454 (1991)
   PUBMED   2062660
REFERENCE   8  (residues 1 to 319)
  AUTHORS   Varnum,B.C., Ma,Q.F., Chi,T.H., Fletcher,B. and Herschman,H.R.
  TITLE     The TIS11 primary response gene is a member of a gene family that
            encodes proteins with a highly conserved sequence containing an
            unusual Cys-His repeat
  JOURNAL   Mol Cell Biol 11 (3), 1754-1758 (1991)
   PUBMED   1996120
REFERENCE   9  (residues 1 to 319)
  AUTHORS   DuBois,R.N., McLane,M.W., Ryder,K., Lau,L.F. and Nathans,D.
  TITLE     A growth factor-inducible nuclear protein with a novel
            cysteine/histidine repetitive sequence
  JOURNAL   J Biol Chem 265 (31), 19185-19191 (1990)
   PUBMED   1699942
REFERENCE   10 (residues 1 to 319)
  AUTHORS   Lai,W.S., Stumpo,D.J. and Blackshear,P.J.
  TITLE     Rapid insulin-stimulated accumulation of an mRNA encoding a
            proline-rich protein
  JOURNAL   J Biol Chem 265 (27), 16556-16563 (1990)
   PUBMED   2204625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149606.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154825.1, SRR7345562.3315002.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.72 cM"
     Protein         1..319
                     /product="mRNA decay activator protein ZFP36"
                     /note="tristetraprolin; tristetraproline; TPA-induced
                     sequence 11; growth factor-inducible nuclear protein
                     NUP475"
                     /calculated_mol_wt=33482
     Region          1..166
                     /region_name="Necessary for localization of ARE-containing
                     mRNAs to processing bodies (PBs).
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          1..92
                     /region_name="Necessary and sufficient for the association
                     with mRNA decay enzymes and mRNA decay activation.
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          1..15
                     /region_name="Necessary for nuclear export.
                     /evidence=ECO:0000250|UniProtKB:P47973"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPKAPK2.
                     /evidence=ECO:0000269|PubMed:14688255,
                     ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20595389;
                     propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Region          65..95
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            80
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:14688255; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:14688255; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            84
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:14688255; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Region          87..160
                     /region_name="Necessary for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:P47973"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          89..165
                     /region_name="Necessary for RNA-binding.
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          92..319
                     /region_name="Necessary for localization of ARE-containing
                     mRNAs to processing bodies (PBs).
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          95..186
                     /region_name="Necessary for interaction with PABPN1.
                     /evidence=ECO:0000269|PubMed:22844456"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          <96..>166
                     /region_name="CTH1"
                     /note="CCCH-type Zn-finger protein [General function
                     prediction only]; COG5063"
                     /db_xref="CDD:227395"
     Region          166..319
                     /region_name="Necessary for mRNA decay activation.
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            178
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPKAPK2.
                     /evidence=ECO:0000269|PubMed:14688255,
                     ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20595389;
                     propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Region          179..309
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            189
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK1, in vitro.
                     /evidence=ECO:0000269|PubMed:7768935; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:14688255; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            269
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P26651; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     Region          305..319
                     /region_name="Interaction with CNOT1.
                     /evidence=ECO:0000250|UniProtKB:P26651"
                     /note="propagated from UniProtKB/Swiss-Prot (P22893.1)"
     Site            316
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:14688255; propagated from
                     UniProtKB/Swiss-Prot (P22893.1)"
     CDS             1..319
                     /gene="Zfp36"
                     /gene_synonym="Gos24; Nup475; Tis11; TIS11D; TISII; Ttp;
                     Zfp-36"
                     /coded_by="NM_011756.5:59..1018"
                     /db_xref="CCDS:CCDS21041.1"
                     /db_xref="GeneID:22695"
                     /db_xref="MGI:MGI:99180"
ORIGIN      
        1 mdlsaiyesl qsmshdlssd hggteslggl wninsdsips gvtsrltgrs tslvegrscg
       61 wvppppgfap laprpgpels psptsptatp ttssryktel crtysesgrc rygakcqfah
      121 glgelrqanr hpkyktelch kfylqgrcpy gsrchfihnp tedlalpgqp hvlrqsisfs
      181 glpsgrrssp pppgfsgpsl sscsfspsss ppppgdlpls psafsaapgt pvtrrdpnqa
      241 ccpscrrstt pstiwgplgg larspsahsl gsdpddyass gsslggsdsp vfeagvfgpp
      301 qtpapprrlp ifnrisvse
//
LOCUS       NP_001191162             294 aa            linear   ROD 27-AUG-2025
DEFINITION  osteopontin isoform 4 precursor [Mus musculus].
ACCESSION   NP_001191162
VERSION     NP_001191162.1
DBSOURCE    REFSEQ: accession NM_001204233.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 294)
  AUTHORS   Cain,J.W., Erikson,D.W., Seo,H., Ross,A., Burghardt,R.C.,
            Bazer,F.W. and Johnson,G.A.
  TITLE     SPARC expression in the mouse decidua, placenta, and fetus:
            correlations with SPP1 expression
  JOURNAL   Placenta 168, 125-134 (2025)
   PUBMED   40544540
REFERENCE   2  (residues 1 to 294)
  AUTHORS   Moraitis,I., Taelman,J., Arozamena,B., Mularoni,L., Wienskowska,O.,
            Sanjuan Garriga,X., Arregui,L., Stefanovic,M., Modolell Farre,I.,
            Guedea,F., Diaz,M. and Guiu,J.
  TITLE     Mucosal Macrophages Govern Intestinal Regeneration in Response to
            Injury
  JOURNAL   Gastroenterology 169 (1), 119-135 (2025)
   PUBMED   40086603
REFERENCE   3  (residues 1 to 294)
  AUTHORS   Wu,S., Bian,Y., Zhang,C., Liu,K., Sun,F., Chen,E., Zhou,C., Yu,L.,
            Chen,G. and Wu,M.
  TITLE     Merlin controls limb development and thumb formation by regulating
            primary cilium-hedgehog signaling
  JOURNAL   Cell Rep 44 (6), 115849 (2025)
   PUBMED   40503937
REFERENCE   4  (residues 1 to 294)
  AUTHORS   Trehan,R., Huang,P., Zhu,X.B., Wang,X., Soliman,M., Strepay,D.,
            Nur,A., Kedei,N., Arhin,M., Ghabra,S., Rodriguez-Matos,F.,
            Benmebarek,M.R., Ma,C., Korangy,F. and Greten,T.F.
  TITLE     SPP1 + macrophages cause exhaustion of tumor-specific T cells in
            liver metastases
  JOURNAL   Nat Commun 16 (1), 4242 (2025)
   PUBMED   40335453
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 294)
  AUTHORS   Jafree,D.J., Perera,C., Ball,M., Tolomeo,D., Pomeranz,G.,
            Wilson,L., Davis,B., Mason,W.J., Funk,E.M., Kolatsi-Joannou,M.,
            Polschi,R., Malik,S., Stewart,B.J., Price,K.L., Mitchell,H.,
            Motallebzadeh,R., Muto,Y., Lees,R., Needham,S., Moulding,D.,
            Chandler,J.C., Nandanwar,S., Walsh,C.L., Winyard,P.J.D.,
            Scambler,P.J., Hagerling,R., Clatworthy,M.R., Humphreys,B.D.,
            Lythgoe,M.F., Walker-Samuel,S., Woolf,A.S. and Long,D.A.
  TITLE     Microvascular aberrations found in human polycystic kidneys are an
            early feature in a Pkd1 mutant mouse model
  JOURNAL   Dis Model Mech 18 (4) (2025)
   PUBMED   40114603
REFERENCE   6  (residues 1 to 294)
  AUTHORS   Worcester,E.M., Blumenthal,S.S., Beshensky,A.M. and Lewand,D.L.
  TITLE     The calcium oxalate crystal growth inhibitor protein produced by
            mouse kidney cortical cells in culture is osteopontin
  JOURNAL   J Bone Miner Res 7 (9), 1029-1036 (1992)
   PUBMED   1414495
REFERENCE   7  (residues 1 to 294)
  AUTHORS   Waterhouse,P., Parhar,R.S., Guo,X., Lala,P.K. and Denhardt,D.T.
  TITLE     Regulated temporal and spatial expression of the calcium-binding
            proteins calcyclin and OPN (osteopontin) in mouse tissues during
            pregnancy
  JOURNAL   Mol Reprod Dev 32 (4), 315-323 (1992)
   PUBMED   1497879
REFERENCE   8  (residues 1 to 294)
  AUTHORS   Kozak,C.A. and Stephenson,D.A.
  TITLE     Mouse chromosome 5
  JOURNAL   Mamm Genome 3 Spec No, S65-S80 (1992)
   PUBMED   1498444
  REMARK    Review article
REFERENCE   9  (residues 1 to 294)
  AUTHORS   Craig,A.M. and Denhardt,D.T.
  TITLE     The murine gene encoding secreted phosphoprotein 1 (osteopontin):
            promoter structure, activity, and induction in vivo by estrogen and
            progesterone
  JOURNAL   Gene 100, 163-171 (1991)
   PUBMED   2055467
REFERENCE   10 (residues 1 to 294)
  AUTHORS   Groves,M.G. and Osterman,J.V.
  TITLE     Host defenses in experimental scrub typhus: genetics of natural
            resistance to infection
  JOURNAL   Infect Immun 19 (2), 583-588 (1978)
   PUBMED   415980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124106.11.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, uses a
            downstream in-frame start codon and lacks an exon in the coding
            region, compared to variant 1. Variants 4 and 5 encode the same
            isoform (4), which is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16151.1, X13986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     Protein         1..294
                     /product="osteopontin isoform 4 precursor"
                     /note="minopontin; early T-lymphocyte activation 1
                     protein; calcium oxalate crystal growth inhibitor protein;
                     bone sialoprotein 1; osteopontin-like protein; 44 kDa bone
                     phosphoprotein"
                     /calculated_mol_wt=30746
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1731
     mat_peptide     17..294
                     /product="Osteopontin. /id=PRO_0000020322"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
                     /calculated_mol_wt=30746
     Region          22..294
                     /region_name="Osteopontin"
                     /note="pfam00865"
                     /db_xref="CDD:459969"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Region          42..274
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            80
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            112
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            123
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            132
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            137
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Region          144..146
                     /region_name="Cell attachment site"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            170
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            176
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            219
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            234
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            260
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            271
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            288
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            288
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            290
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     CDS             1..294
                     /gene="Spp1"
                     /gene_synonym="2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1;
                     OP; Opn; Opnl; Ric; Spp-1"
                     /coded_by="NM_001204233.1:198..1082"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 5"
                     /db_xref="CCDS:CCDS19486.1"
                     /db_xref="GeneID:20750"
                     /db_xref="MGI:MGI:98389"
ORIGIN      
        1 mrlavicfcl fgiasslpvk vtdsgsseek lyslhpdpia twlvpdpsqk qnllapqnav
       61 sseekddfkq etlpsnsnes hdhmdddddd ddddgdhaes edsvdsdesd eshhsdesde
      121 tvtastqadt ftpivptvdv pngrgdslay glrsksrsfq vsdeqypdat dedltshmks
      181 geskesldvi pvaqllsmps dqdnngkgsh essqldepsl ethrlehske sqesadqsdv
      241 idsqasskas lehqshkfhs hkdklvldpk skeddrylkf rishelesss sevn
//
LOCUS       NP_081086                760 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh1 isoform 1 [Mus musculus].
ACCESSION   NP_081086
VERSION     NP_081086.2
DBSOURCE    REFSEQ: accession NM_026810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 760)
  AUTHORS   Zhao,B.W., Zhang,Y.N., Meng,T.G., Xu,Y.H., Lu,Y.K., Sun,S.M.,
            Guo,J.N., Yang,X.M. and Wang,Z.B.
  TITLE     Re-establishment of H3K9me2 eliminates the transcriptional
            inhibition of ST18 on meiotic genes and orchestrates female germ
            cell development
  JOURNAL   Nucleic Acids Res 53 (13) (2025)
   PUBMED   40650982
REFERENCE   2  (residues 1 to 760)
  AUTHORS   Wu,Y., Li,Y., Zhang,H., Ye,J., Li,M., Zhou,J., Xie,X., Yin,H.,
            Chen,M., Yang,G., Fan,S., Shi,B., Jiang,H., Shi,Q. and Ma,H.
  TITLE     S100PBP interacts with nucleoporin TPR and facilitates XY crossover
            formation in mice
  JOURNAL   EMBO Rep 26 (9), 2280-2299 (2025)
   PUBMED   40204913
REFERENCE   3  (residues 1 to 760)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell 188 (6), 1524-1544 (2025)
   PUBMED   39938516
REFERENCE   4  (residues 1 to 760)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   5  (residues 1 to 760)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 760)
  AUTHORS   Prolla,T.A., Baker,S.M., Harris,A.C., Tsao,J.L., Yao,X.,
            Bronner,C.E., Zheng,B., Gordon,M., Reneker,J., Arnheim,N.,
            Shibata,D., Bradley,A. and Liskay,R.M.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
REFERENCE   7  (residues 1 to 760)
  AUTHORS   Baker,S.M., Plug,A.W., Prolla,T.A., Bronner,C.E., Harris,A.C.,
            Yao,X., Christie,D.M., Monell,C., Arnheim,N., Bradley,A., Ashley,T.
            and Liskay,R.M.
  TITLE     Involvement of mouse Mlh1 in DNA mismatch repair and meiotic
            crossing over
  JOURNAL   Nat Genet 13 (3), 336-342 (1996)
   PUBMED   8673133
REFERENCE   8  (residues 1 to 760)
  AUTHORS   Edelmann,W., Cohen,P.E., Kane,M., Lau,K., Morrow,B., Bennett,S.,
            Umar,A., Kunkel,T., Cattoretti,G., Chaganti,R., Pollard,J.W.,
            Kolodner,R.D. and Kucherlapati,R.
  TITLE     Meiotic pachytene arrest in MLH1-deficient mice
  JOURNAL   Cell 85 (7), 1125-1134 (1996)
   PUBMED   8674118
REFERENCE   9  (residues 1 to 760)
  AUTHORS   Zechmeister-Machhart,M., Hufnagl,P., Uhrin,P., Xu,J., Geiger,M. and
            Binder,B.R.
  TITLE     Molecular cloning and tissue distribution of mouse protein C
            inhibitor (PCI)
  JOURNAL   Immunopharmacology 32 (1-3), 96-98 (1996)
   PUBMED   8796278
REFERENCE   10 (residues 1 to 760)
  AUTHORS   Bronner,C.E., Baker,S.M., Morrison,P.T., Warren,G., Smith,L.G.,
            Lescoe,M.K., Kane,M., Earabino,C., Lipford,J., Lindblom,A. et al.
  TITLE     Mutation in the DNA mismatch repair gene homologue hMLH1 is
            associated with hereditary non-polyposis colon cancer
  JOURNAL   Nature 368 (6468), 258-261 (1994)
   PUBMED   8145827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY327218.1, AK145646.1 and AK163861.1.
            
            On Aug 14, 2009 this sequence version replaced NP_081086.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021815.1, AK145646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.92 cM"
     Protein         1..760
                     /product="DNA mismatch repair protein Mlh1 isoform 1"
                     /note="DNA mismatch repair protein MLH1; mutL protein
                     homolog 1; colon cancer, nonpolyposis type 2"
                     /calculated_mol_wt=84539
     Region          6..315
                     /region_name="mutl"
                     /note="DNA mismatch repair protein MutL; TIGR00585"
                     /db_xref="CDD:273155"
     Site            33
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40692; propagated from
                     UniProtKB/Swiss-Prot (Q9JK91.2)"
     Site            241
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40692; propagated from
                     UniProtKB/Swiss-Prot (Q9JK91.2)"
     Region          354..375
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK91.2)"
     Site            377
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40692; propagated from
                     UniProtKB/Swiss-Prot (Q9JK91.2)"
     Region          400..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK91.2)"
     Region          412..654
                     /region_name="Interaction with EXO1.
                     /evidence=ECO:0000250|UniProtKB:P40692"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK91.2)"
     Region          475..478
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P40692"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JK91.2)"
     Site            481
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P40692; propagated from
                     UniProtKB/Swiss-Prot (Q9JK91.2)"
     Region          506..760
                     /region_name="Mlh1_C"
                     /note="DNA mismatch repair protein Mlh1 C-terminus;
                     pfam16413"
                     /db_xref="CDD:465109"
     CDS             1..760
                     /gene="Mlh1"
                     /gene_synonym="1110035C23Rik"
                     /coded_by="NM_026810.2:85..2367"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40784.1"
                     /db_xref="GeneID:17350"
                     /db_xref="MGI:MGI:101938"
ORIGIN      
        1 mafvagvirr ldetvvnria ageviqrpan aikemiencl dakstniqvv vkegglkliq
       61 iqdngtgirk edldivcerf ttsklqtfed lasistygfr gealasishv ahvtittkta
      121 dgkcayrasy sdgklqappk pcagnqgtli tvedlfynii trrkalknps eeygkilevv
      181 grysihnsgi sfsvkkqget vsdvrtlpna ttvdnirsif gnavsrelie vgcedktlaf
      241 kmngyisnan ysvkkcifll finhrlvesa alrkaietvy aaylpknthp flylsleisp
      301 qnvdvnvhpt khevhflhee silqrvqqhi eskllgsnss rmyftqtllp glagpsgeaa
      361 rpttgvasss tsgsgdkvya yqmvrtdsre qkldaflqpv sslgpsqpqd papvrgarte
      421 gsperatred eemlalpapa eaaaesenle reslmetsda aqkaaptssp gssrkrhred
      481 sdvemvenas gkemtaacyp rrriinltsv lslqeeiser chetlremlr nhsfvgcvnp
      541 qwalaqhqtk lyllnttkls eelfyqiliy dfanfgvlrl sepaplfdla mlaldspesg
      601 wteddgpkeg laeyiveflk kkaemladyf sveideegnl iglpllidsy vppleglpif
      661 ilrlatevnw deekecfesl skecamfysi rkqyileest lsgqqsdmpg stskpwkwtv
      721 ehiiykafrs hllppkhfte dgnvlqlanl pdlykvferc
//
LOCUS       NP_001153020             438 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor subfamily 6 group A member 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001153020
VERSION     NP_001153020.1
DBSOURCE    REFSEQ: accession NM_001159548.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 438)
  AUTHORS   Neelathi,U.M., Ullah,E., George,A., Maftei,M.I., Boobalan,E.,
            Sanchez-Mendoza,D., Adams,C., McGaughey,D., Sergeev,Y.V., Ai
            Rawi,R., Naik,A., Bender,C., Maumenee,I.H., Michaelides,M.,
            Tan,T.G., Lin,S., Villasmil,R., Blain,D., Hufnagel,R.B., Arno,G.,
            Young,R.M., Guan,B. and Brooks,B.P.
  TITLE     Variants in NR6A1 cause a novel oculo vertebral renal syndrome
  JOURNAL   Nat Commun 16 (1), 6111 (2025)
   PUBMED   40610405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 438)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 438)
  AUTHORS   Chang,Y.C., Manent,J., Schroeder,J., Wong,S.F.L., Hauswirth,G.M.,
            Shylo,N.A., Moore,E.L., Achilleos,A., Garside,V., Polo,J.M.,
            Trainor,P. and McGlinn,E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 438)
  AUTHORS   Tan,P., Xue,T., Wang,Y., Hu,Z., Su,J., Yang,R., Ji,J., Ye,M.,
            Chen,Z., Huang,C. and Lu,X.
  TITLE     Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the
            development of depression-like behaviors in mice
  JOURNAL   Neuropharmacology 209, 108990 (2022)
   PUBMED   35183538
  REMARK    GeneRIF: Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to
            the development of depression-like behaviors in mice.
REFERENCE   5  (residues 1 to 438)
  AUTHORS   Koutelou,E., Wang,L., Schibler,A.C., Chao,H.P., Kuang,X., Lin,K.,
            Lu,Y., Shen,J., Jeter,C.R., Salinger,A., Wilson,M., Chen,Y.C.,
            Atanassov,B.S., Tang,D.G. and Dent,S.Y.R.
  TITLE     USP22 controls multiple signaling pathways that are essential for
            vasculature formation in the mouse placenta
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30718289
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 438)
  AUTHORS   Kapelle,M., Kratzschmar,J., Husemann,M. and Schleuning,W.D.
  TITLE     cDNA cloning of two closely related forms of human germ cell
            nuclear factor (GCNF)
  JOURNAL   Biochim Biophys Acta 1352 (1), 13-17 (1997)
   PUBMED   9177477
REFERENCE   7  (residues 1 to 438)
  AUTHORS   Yan,Z.H., Medvedev,A., Hirose,T., Gotoh,H. and Jetten,A.M.
  TITLE     Characterization of the response element and DNA binding properties
            of the nuclear orphan receptor germ cell nuclear factor/retinoid
            receptor-related testis-associated receptor
  JOURNAL   J Biol Chem 272 (16), 10565-10572 (1997)
   PUBMED   9099702
REFERENCE   8  (residues 1 to 438)
  AUTHORS   Joos,T.O., David,R. and Dreyer,C.
  TITLE     xGCNF, a nuclear orphan receptor is expressed during neurulation in
            Xenopus laevis
  JOURNAL   Mech Dev 60 (1), 45-57 (1996)
   PUBMED   9025060
REFERENCE   9  (residues 1 to 438)
  AUTHORS   Hirose,T., O'Brien,D.A. and Jetten,A.M.
  TITLE     RTR: a new member of the nuclear receptor superfamily that is
            highly expressed in murine testis
  JOURNAL   Gene 152 (2), 247-251 (1995)
   PUBMED   7835709
REFERENCE   10 (residues 1 to 438)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN537407.1, CK638822.1, CN532747.1 and AL844842.29.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.735860.1,
                                           SRR9219383.128114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     Protein         1..438
                     /product="nuclear receptor subfamily 6 group A member 1
                     isoform 2"
                     /note="mGCNF; retinoid receptor-related testis-specific
                     receptor; germ cell nuclear factor"
                     /calculated_mol_wt=50314
     Region          10..99
                     /region_name="NR_DBD_GCNF_like"
                     /note="DNA-binding domain of Germ cell nuclear factor
                     (GCNF) F1 is composed of two C4-type zinc fingers;
                     cd07169"
                     /db_xref="CDD:143543"
     Site            order(18,21,35,38,54,60,70,73)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143543"
     Site            order(28..30,36..37,39,41,44,47,67..68,71,74,85,88)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143543"
     Region          214..425
                     /region_name="NR_LBD_DHR4_like"
                     /note="The ligand binding domain of orphan nuclear
                     receptor Ecdysone-induced receptor DHR4; cd06953"
                     /db_xref="CDD:132751"
     Site            order(244..245,249,283,287,290,304,327)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:132751"
     Site            order(254,257,261,266,271..272,274..275,278..279)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132751"
     CDS             1..438
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /coded_by="NM_001159548.1:108..1424"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS50581.1"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
ORIGIN      
        1 metwevsvpd draeqrtcli cgdratglhy giiscegckg ffkrsicnkr vyrcsrdknc
       61 vmsrkqrnrc qycrllkclq mgmnrkaire dgmpggrnks igpvqiseee ierimsgqef
      121 eeeanhwsnh gdsdhsspgn rasesnqpsp gstlsssrsv elngfmafrd qymgmsvpph
      181 yqyiphlfsy sghspllppq arsldpqsys lihqlmsaed leplgtpmli edgyavtqae
      241 lfallcrlad ellfrqiawi kklpffcels ikdytcllss twqelillss ltvyskqifg
      301 eladvtakys psdeelhrfs degmevierl iylyhkfhql kvsneeyacm kainflnqdi
      361 rgltsasqle qlnkrywyic qdfteykyth qpnrfpdlmm clpeiryiag kmvnvpleql
      421 pllfkvvlhs cktstvke
//
LOCUS       NP_035667                518 aa            linear   ROD 27-AUG-2025
DEFINITION  T-box transcription factor TBX5 [Mus musculus].
ACCESSION   NP_035667
VERSION     NP_035667.1
DBSOURCE    REFSEQ: accession NM_011537.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 518)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 518)
  AUTHORS   Yamaguchi,H., Tran,L.T., Bi,J., Urayama,A., Yutzey,K.E., Mishina,Y.
            and Komatsu,Y.
  TITLE     Enhanced BMP signaling in cranial neural crest cells induces
            aberrant chondrogenesis by upregulating Tbx20 expression during
            craniofacial development
  JOURNAL   Biochem Biophys Res Commun 765, 151834 (2025)
   PUBMED   40273622
REFERENCE   3  (residues 1 to 518)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Lu,Y., Liu,E.,
            Kim,I.M., Jiao,K., Weintraub,N.L., Zhou,J., Li,J. and Su,H.
  TITLE     Neddylation drives myofibrillogenesis in the developing heart
  JOURNAL   FASEB J 38 (24), e70260 (2024)
   PUBMED   39698930
REFERENCE   4  (residues 1 to 518)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 518)
  AUTHORS   Guijarro,C., Song,S., Aigouy,B., Clement,R., Villoutreix,P. and
            Kelly,R.G.
  TITLE     Single-cell morphometrics reveals T-box gene-dependent patterns of
            epithelial tension in the Second Heart field
  JOURNAL   Nat Commun 15 (1), 9512 (2024)
   PUBMED   39496595
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 518)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   7  (residues 1 to 518)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   8  (residues 1 to 518)
  AUTHORS   Gibson-Brown,J.J., Agulnik,S.I., Chapman,D.L., Alexiou,M.,
            Garvey,N., Silver,L.M. and Papaioannou,V.E.
  TITLE     Evidence of a role for T-box genes in the evolution of limb
            morphogenesis and the specification of forelimb/hindlimb identity
  JOURNAL   Mech Dev 56 (1-2), 93-101 (1996)
   PUBMED   8798150
REFERENCE   9  (residues 1 to 518)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
REFERENCE   10 (residues 1 to 518)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090639.1, BX529547.1 and AI413447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090639.1, AF140427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.42 cM"
     Protein         1..518
                     /product="T-box transcription factor TBX5"
                     /note="T-box protein 5"
                     /calculated_mol_wt=57701
     Region          1..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70326.2)"
     Region          54..238
                     /region_name="T-box_TBX4_5-like"
                     /note="DNA-binding domain of T-box transcription factor 4
                     and 5, and related T-box proteins; cd20189"
                     /db_xref="CDD:410315"
     Site            order(81..82,159,162,175..176,215,217,223,226..227,
                     230..236)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410315"
     Site            order(101,108..109,128,131,133,135,137,141..142,182,184,
                     187,199..201)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410315"
     Site            order(140..142,150)
                     /site_type="other"
                     /note="NKX2.5 interface [polypeptide binding]"
                     /db_xref="CDD:410315"
     Region          254..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70326.2)"
     Region          330..352
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70326.2)"
     Site            339
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99593; propagated from
                     UniProtKB/Swiss-Prot (P70326.2)"
     CDS             1..518
                     /gene="Tbx5"
                     /coded_by="NM_011537.3:654..2210"
                     /db_xref="CCDS:CCDS19615.1"
                     /db_xref="GeneID:21388"
                     /db_xref="MGI:MGI:102541"
ORIGIN      
        1 madtdegfgl artplepdsk drscdskpes algapsksps spqaaftqqg megikvflhe
       61 relwlkfhev gtemiitkag rrmfpsykvk vtglnpktky illmdivpad dhrykfadnk
      121 wsvtgkaepa mpgrlyvhpd spatgahwmr qlvsfqklkl tnnhldpfgh iilnsmhkyq
      181 prlhivkade nngfgsknta fcthvfpeta fiavtsyqnh kitqlkienn pfakgfrgsd
      241 dlelhrmsrm qskeypvvpr stvrhkvtsn hspfssetra lstssnlgsq yqcengvsgp
      301 sqdllpppnp yplaqehsqi yhctkrkdee csstehpykk pymetspsee dtfyrsgypq
      361 qqglstsyrt esaqrqacmy assappsepv pslediscnt wpsmpsyssc tvttvqpmdr
      421 lpyqhfsahf tsgplvprla gmanhgspql gegmfqhqts vahqpvvrqc gpqtglqspg
      481 glqppeflyt hgvprtlsph qyhsvhgvgm vpewsens
//
LOCUS       NP_001407184            1013 aa            linear   ROD 27-AUG-2025
DEFINITION  anoctamin-1 isoform 3 [Mus musculus].
ACCESSION   NP_001407184 XP_036008438
VERSION     NP_001407184.1
DBSOURCE    REFSEQ: accession NM_001420255.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1013)
  AUTHORS   Chakraborty,S., Wenzlitschke,N., Anderson,M.J., Eraso,A.,
            Baudic,M., Thompson,J.J., Evans,A.A., Shatford-Adams,L.M.,
            Chari,R., Awasthi,P., Dale,R.K., Lewandoski,M., Petros,T.J. and
            Rocha,P.P.
  TITLE     Deletion of a single CTCF motif at the boundary of a chromatin
            domain with three FGF genes disrupts gene expression and embryonic
            development
  JOURNAL   Dev Cell 60 (13), 1838-1853 (2025)
   PUBMED   40015278
REFERENCE   2  (residues 1 to 1013)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   3  (residues 1 to 1013)
  AUTHORS   Penrod,S., Tang,X., Moon,C., Whitsett,J.A., Naren,A.P. and Huang,Y.
  TITLE     EMC3 is critical for CFTR function and calcium mobilization in the
            mouse intestinal epithelium
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 328 (1), G72-G82 (2025)
   PUBMED   39641142
REFERENCE   4  (residues 1 to 1013)
  AUTHORS   Sun,Z., Shan,X., Fan,C., Liu,L., Li,S., Wang,J., Zhou,N., Zhu,M.
            and Chen,H.
  TITLE     TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity
  JOURNAL   Stem Cells 42 (10), 902-913 (2024)
   PUBMED   39097775
  REMARK    GeneRIF: TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity.
REFERENCE   5  (residues 1 to 1013)
  AUTHORS   Raghavan,S., Brishti,M.A., Bernardelli,A., Mata-Daboin,A.,
            Jaggar,J.H. and Leo,M.D.
  TITLE     Extracellular glucose and dysfunctional insulin receptor signaling
            independently upregulate arterial smooth muscle TMEM16A expression
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1237-C1247 (2024)
   PUBMED   38581667
  REMARK    GeneRIF: Extracellular glucose and dysfunctional insulin receptor
            signaling independently upregulate arterial smooth muscle TMEM16A
            expression.
REFERENCE   6  (residues 1 to 1013)
  AUTHORS   Yang,Y.D., Cho,H., Koo,J.Y., Tak,M.H., Cho,Y., Shim,W.S.,
            Park,S.P., Lee,J., Lee,B., Kim,B.M., Raouf,R., Shin,Y.K. and Oh,U.
  TITLE     TMEM16A confers receptor-activated calcium-dependent chloride
            conductance
  JOURNAL   Nature 455 (7217), 1210-1215 (2008)
   PUBMED   18724360
  REMARK    GeneRIF: transmembrane protein 16A (TMEM16A, which we also call
            anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride
            channel that is activated by intracellular Ca(2+) and
            Ca(2+)-mobilizing stimuli
REFERENCE   7  (residues 1 to 1013)
  AUTHORS   Rock,J.R., Futtner,C.R. and Harfe,B.D.
  TITLE     The transmembrane protein TMEM16A is required for normal
            development of the murine trachea
  JOURNAL   Dev Biol 321 (1), 141-149 (2008)
   PUBMED   18585372
  REMARK    GeneRIF: Study reports that all mice homozygous for a null allele
            of Tmem16a died within one month of birth and exhibited severe
            tracheomalacia with gaps in the tracheal cartilage rings along the
            entire length of the trachea.
REFERENCE   8  (residues 1 to 1013)
  AUTHORS   Rock,J.R., Lopez,M.C., Baker,H.V. and Harfe,B.D.
  TITLE     Identification of genes expressed in the mouse limb using a novel
            ZPA microarray approach
  JOURNAL   Gene Expr Patterns 8 (1), 19-26 (2007)
   PUBMED   17911046
REFERENCE   9  (residues 1 to 1013)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   10 (residues 1 to 1013)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122336.4 and AC153792.4.
            
            On Apr 27, 2023 this sequence version replaced XP_036008438.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.101681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.85 cM"
     Protein         1..1013
                     /product="anoctamin-1 isoform 3"
                     /note="transmembrane protein 16A; anoctamin-1"
                     /calculated_mol_wt=116241
     Region          111..374
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          377..953
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1013
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /coded_by="NM_001420255.1:130..3171"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:101772"
                     /db_xref="MGI:MGI:2142149"
ORIGIN      
        1 mqdaqdsdig legltpegts adrecqrgpe tiaheaqdag tpnsdatgvv dgereatmrv
       61 pekystlpae drsvhivnic aiedlgylps egtllnslsv dpdaeckygl yfrdgkrkvd
      121 yilvyhhkra sgsrtlarrg lqndmvlgtr svrqdqplpg kgspvdagsp evpmdyhedd
      181 krfrreeyeg nlleaglele ndedtkihgv gfvkihapwh vlcreaeflk lkmptkkvyh
      241 isetrgllkt insvlqkitd piqpkvaehr pqttkrlsyp fsrekqhlfd ltdrdsffds
      301 ktrstivyei lkrttctkak ysmgitslla ngvysaaypl hdgdyegdnv efndrkllye
      361 ewasygvfyk yqpidlvrky fgekvglyfa wlgaytqmli pasivgvivf lygcatvden
      421 ipsmemcdqr ynitmcplcd ktcsywkmss acatarashl fdnpatvffs vfmalwaatf
      481 mehwkrkqmr lnyrwdltgf eeeedhprae yearvleksl rkesrnketd kvkltwrdrf
      541 payftnlvsi ifmiavtfai vlgviiyris taaalamnss psvrsnirvt vtataviinl
      601 vviilldevy gciarwltki evpkteksfe erltfkafll kfvnsytpif yvaffkgrfv
      661 grpgdyvyif rsfrmeecap ggclmelciq lsiimlgkql iqnnlfeigi pkmkkfiryl
      721 klrrqspsdr eeyvkrkqry evdfnlepfa gltpeymemi iqfgfvtlfv asfplaplfa
      781 llnniieirl dakkfvtelr rpvairakdi giwynilrgv gklaviinaf visftsdfip
      841 rlvylymysq ngtmhgfvnh tlssfnvsdf qngtapndpl dlgyevqicr ykdyreppws
      901 ehkydiskdf wavlaarlaf vivfqnlvmf msdfvdwvip dipkdisqqi hkekvlmvel
      961 fmreeqgkqq lldtwmekek prdvpcnnhs ptthpeagdg spvpsyeyhg dal
//
LOCUS       NP_001076785            1089 aa            linear   ROD 27-AUG-2025
DEFINITION  platelet-derived growth factor receptor alpha isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_001076785
VERSION     NP_001076785.1
DBSOURCE    REFSEQ: accession NM_001083316.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1089)
  AUTHORS   Tran,L.N., Shinde,A., Schuster,K.H., Sabaawy,A., Dale,E.,
            Welch,M.J., Isner,T.J., Nunez,S.A., Garcia-Moreno,F.,
            Sagerstrom,C.G., Appel,B.H. and Franco,S.J.
  TITLE     Epigenetic priming of neural progenitors by Notch enhances Sonic
            hedgehog signaling and establishes gliogenic competence
  JOURNAL   Genes Dev 39 (13-14), 886-906 (2025)
   PUBMED   40404401
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1089)
  AUTHORS   Summers,B.S., Blizzard,C.A., Ricci,R.R., Pitman,K.A., Dempsey,B.,
            McMullan,S., Sutherland,B.A., Young,K.M. and Cullen,C.L.
  TITLE     Demyelination Produces a Shift in the Population of Cortical
            Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40345851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1089)
  AUTHORS   Van Hove,H., Gluck,C., Mildenberger,W., Petrova,E., Maheshwari,U.,
            Hane,P., Kreiner,V., Bijnen,M., Mussak,C., Utz,S.G., Droux,J.,
            Ingelfinger,F., Ashworth,C., Stifter,S.A., Roussel,E., Lelios,I.,
            Vermeer,M., Huang,S.F., Zhou,Q., Chen,Z., Calvet,C., Bourgeois,S.,
            Schaffenrath,J., Razansky,D., Juang,J.X., Asano,K., Pelczar,P.,
            Mundt,S., Weber,B., Wegener,S., Tugues,S., Stockmann,C., Becher,B.,
            Keller,A., El Amki,M. and Greter,M.
  TITLE     Interleukin-34-dependent perivascular macrophages promote vascular
            function in the brain
  JOURNAL   Immunity 58 (5), 1289-1305 (2025)
   PUBMED   40315842
REFERENCE   4  (residues 1 to 1089)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1089)
  AUTHORS   Mueller,A.A., van Velthoven,C.T., Fukumoto,K.D., Cheung,T.H. and
            Rando,T.A.
  TITLE     Intronic polyadenylation of PDGFRalpha in resident stem cells
            attenuates muscle fibrosis
  JOURNAL   Nature 540 (7632), 276-279 (2016)
   PUBMED   27894125
  REMARK    GeneRIF: polyadenylation of a PDGFRalpha intron in resident stem
            cells attenuates muscle fibrosis
REFERENCE   6  (residues 1 to 1089)
  AUTHORS   Demoulin,J.B. and Essaghir,A.
  TITLE     PDGF receptor signaling networks in normal and cancer cells
  JOURNAL   Cytokine Growth Factor Rev 25 (3), 273-283 (2014)
   PUBMED   24703957
  REMARK    Review article
REFERENCE   7  (residues 1 to 1089)
  AUTHORS   Palmieri,S.L., Payne,J., Stiles,C.D., Biggers,J.D. and Mercola,M.
  TITLE     Expression of mouse PDGF-A and PDGF alpha-receptor genes during
            pre- and post-implantation development: evidence for a
            developmental shift from an autocrine to a paracrine mode of action
  JOURNAL   Mech Dev 39 (3), 181-191 (1992)
   PUBMED   1292572
REFERENCE   8  (residues 1 to 1089)
  AUTHORS   Do,M.S., Fitzer-Attas,C., Gubbay,J., Greenfeld,L., Feldman,M. and
            Eisenbach,L.
  TITLE     Mouse platelet-derived growth factor alpha receptor: sequence,
            tissue-specific expression and correlation with metastatic
            phenotype
  JOURNAL   Oncogene 7 (8), 1567-1575 (1992)
   PUBMED   1321404
REFERENCE   9  (residues 1 to 1089)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   10 (residues 1 to 1089)
  AUTHORS   Truslove,G.M.
  TITLE     A new allele at the patch locus in the mouse
  JOURNAL   Genet Res 29 (2), 183-186 (1977)
   PUBMED   863250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC053036.1, CD354225.1,
            AK147267.1, BY628767.1 and CK627326.1.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins. Binding of platelet-derived growth factor
            protein ligands to this receptor triggers receptor dimerization and
            autophosphorylation, resulting in the activation of several
            downstream signaling pathways. Signaling through the encoded
            receptor plays a role in gastrulation and the development of nearly
            all organ systems. Mice lacking a functional copy of this gene
            reportedly exhibit defects in lung, skeleton, testis and the
            central nervous system, and die soon after birth. Alternative
            splicing and intronic polyadenylation of gene transcripts have been
            implicated in muscle regeneration and fibrosis in adult mice.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053036.1, SRR1660817.309700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     Protein         1..1089
                     /product="platelet-derived growth factor receptor alpha
                     isoform 1 precursor"
                     /EC_number="2.7.10.1"
                     /note="alpha-type platelet-derived growth factor receptor;
                     platelet-derived growth factor receptor alpha;
                     PDGF-R-alpha; CD140 antigen-like family member A; PDGF
                     alpha chain; Alpha platelet-derived growth factor receptor
                     precursor (PDGF-R-alpha); PDGFR-alpha"
                     /calculated_mol_wt=120197
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
                     /calculated_mol_wt=2505
     mat_peptide     25..1089
                     /product="Platelet-derived growth factor receptor alpha.
                     /id=PRO_0000016761"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
                     /calculated_mol_wt=120197
     Region          28..100
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            76
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            103
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Region          212..310
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          231..235
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          244..248
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          273..277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          302..305
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          313..413
                     /region_name="Ig4_PDGFR"
                     /note="Fourth immunoglobulin (Ig)-like domain of
                     platelet-derived growth factor receptor (PDGFR); cd05859"
                     /db_xref="CDD:409445"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            359
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            458
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            468
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            506
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            529..549
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Region          555..956
                     /region_name="PTKc_PDGFR_alpha"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Platelet Derived Growth Factor Receptor alpha; cd05105"
                     /db_xref="CDD:173653"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            574
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            order(599..600,602..605,607,625,627,675,677,681,818,
                     822..823,825,836,854..858,867,902)
                     /site_type="active"
                     /db_xref="CDD:173653"
     Site            order(599..600,602..605,607,625,627,675,677,681,822..823,
                     825,836)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173653"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234, ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Site            731
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            754
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            762
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            768
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            order(818,822,854..858,867,902)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173653"
     Site            835..860
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173653"
     Site            849
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            988
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Region          1018..1089
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Site            1018
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     CDS             1..1089
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /coded_by="NM_001083316.2:197..3466"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19351.1"
                     /db_xref="GeneID:18595"
                     /db_xref="MGI:MGI:97530"
ORIGIN      
        1 mgtshqvflv lsclltgpgl iscqlllpsi lpnenekivq lnssfslrcv gesevswqhp
       61 mseeddpnve irseennsgl fvtvlevvna saahtgwytc yynhtqtdes eiegrhiyiy
      121 vpdpdmafvp lgmtdslviv eeddsaiipc rttdpetqvt lhnngrlvpa sydsrqgfng
      181 tfsvgpyice atvkgrtfkt sefnvyalka tselnlemda rqtvykaget ivvtcavfnn
      241 evvdlqwtyp gevrnkgitm leeiklpsik lvytltvpka tvkdsgeyec aarqatkevk
      301 emkrvtisvh ekgfveiept fgqleavnlh evrefvvevq ayptpriswl kdnltlienl
      361 teittdvqks qetryqsklk lirakeedsg hytiivqned dvksytfels tlvpasildl
      421 vddhhgsggg qtvrctaegt plpeidwmic khikkcnndt swtvlasnvs niitelprrg
      481 rstvegrvsf akveetiavr claknnlsvv arelklvapt lrseltvaaa vlvllviviv
      541 slivlvviwk qkpryeirwr viesispdgh eyiyvdpmql pydsrwefpr dglvlgrilg
      601 sgafgkvveg tayglsrsqp vmkvavkmlk ptarssekqa lmselkimth lgphlnivnl
      661 lgactksgpi yiiteycfyg dlvnylhknr dsfmsqhpek pkkdldifgl npadestrsy
      721 vilsfenngd ymdmkqadtt qyvpmlerke vskysdiqrs lydrpasykk ksmldsevkn
      781 llsdddsegl tlldllsfty qvargmefla skncvhrdla arnvllaqgk ivkicdfgla
      841 rdimhdsnyv skgstflpvk wmapesifdn lyttlsdvws ygillweifs lggtpypgmm
      901 vdstfynkik sgyrmakpdh atsevyeimv qcwnsepekr psfyhlseiv enllpgqykk
      961 syekihldfl ksdhpavarm rvdsdnayig vtykneedkl kdweggldeq rlsadsgyii
     1021 plpdidpvpe eedlgkrnrh ssqtseesai etgsssstfi kredetiedi dmmddigids
     1081 sdlvedsfl
//
LOCUS       NP_001345373             171 aa            linear   ROD 27-AUG-2025
DEFINITION  peroxiredoxin-5, mitochondrial isoform 2 precursor [Mus musculus].
ACCESSION   NP_001345373
VERSION     NP_001345373.1
DBSOURCE    REFSEQ: accession NM_001358444.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 171)
  AUTHORS   Paulenda,T., Echalar,B., Potuckova,L., Vachova,V., Kleverov,D.A.,
            Mehringer,J., Potekhina,E., Jacoby,A., Sen,D., Nelson,C.,
            Stegeman,R., Sukhov,V., Kemper,D., Lichti,C.F., Day,N.J., Zhang,T.,
            Husarcikova,K., Bambouskova,M., Fremont,D.H., Qian,W.J.,
            Djuranovic,S., Pavlovic-Djuranovic,S., Belousov,V.V., Krezel,A.M.
            and Artyomov,M.N.
  TITLE     Itaconate modulates immune responses via inhibition of
            peroxiredoxin 5
  JOURNAL   Nat Metab 7 (6), 1183-1203 (2025)
   PUBMED   40251412
REFERENCE   2  (residues 1 to 171)
  AUTHORS   Wang,R., Mi,Y., Ni,J., Wang,Y., Ding,L., Ran,X., Sun,Q., Tan,S.Y.,
            Koeffler,H.P., Feng,N. and Chen,Y.Q.
  TITLE     Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer
  JOURNAL   Adv Sci (Weinh) 11 (9), e2304939 (2024)
   PUBMED   38115765
  REMARK    GeneRIF: Identification of PRDX5 as A Target for The Treatment of
            Castration-Resistant Prostate Cancer.
REFERENCE   3  (residues 1 to 171)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 171)
  AUTHORS   Shin,H.J., Lee,S.W., Kim,M.H., Park,Y.H., Lee,H.J. and Lee,D.S.
  TITLE     Mitochondrial peroxiredoxin 5 overexpression suppresses
            insulin-induced adipogenesis by downregulating the phosphorylation
            of p38
  JOURNAL   Biosci Biotechnol Biochem 87 (7), 696-706 (2023)
   PUBMED   37024271
  REMARK    GeneRIF: Mitochondrial peroxiredoxin 5 overexpression suppresses
            insulin-induced adipogenesis by downregulating the phosphorylation
            of p38.
REFERENCE   5  (residues 1 to 171)
  AUTHORS   Cho,E., Che,X., Ang,M.J., Cheon,S., Lee,J., Kim,K.S., Lee,C.H.,
            Lee,S.Y., Yang,H.Y., Moon,C., Park,C., Choi,J.Y. and Lee,T.H.
  TITLE     Peroxiredoxin 5 regulates osteogenic differentiation through
            interaction with hnRNPK during bone regeneration
  JOURNAL   Elife 12, e80122 (2023)
   PUBMED   36735291
  REMARK    GeneRIF: Peroxiredoxin 5 regulates osteogenic differentiation
            through interaction with hnRNPK during bone regeneration.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 171)
  AUTHORS   Knoops,B., Goemaere,J., Van der Eecken,V. and Declercq,J.P.
  TITLE     Peroxiredoxin 5: structure, mechanism, and function of the
            mammalian atypical 2-Cys peroxiredoxin
  JOURNAL   Antioxid Redox Signal 15 (3), 817-829 (2011)
   PUBMED   20977338
  REMARK    Review article
REFERENCE   7  (residues 1 to 171)
  AUTHORS   Zhou,Y., Kok,K.H., Chun,A.C., Wong,C.M., Wu,H.W., Lin,M.C.,
            Fung,P.C., Kung,H. and Jin,D.Y.
  TITLE     Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits
            p53-induced apoptosis
  JOURNAL   Biochem Biophys Res Commun 268 (3), 921-927 (2000)
   PUBMED   10679306
REFERENCE   8  (residues 1 to 171)
  AUTHORS   Knoops,B., Clippe,A., Bogard,C., Arsalane,K., Wattiez,R.,
            Hermans,C., Duconseille,E., Falmagne,P. and Bernard,A.
  TITLE     Cloning and characterization of AOEB166, a novel mammalian
            antioxidant enzyme of the peroxiredoxin family
  JOURNAL   J Biol Chem 274 (43), 30451-30458 (1999)
   PUBMED   10521424
REFERENCE   9  (residues 1 to 171)
  AUTHORS   Yamashita,H., Avraham,S., Jiang,S., London,R., Van Veldhoven,P.P.,
            Subramani,S., Rogers,R.A. and Avraham,H.
  TITLE     Characterization of human and murine PMP20 peroxisomal proteins
            that exhibit antioxidant activity in vitro
  JOURNAL   J Biol Chem 274 (42), 29897-29904 (1999)
   PUBMED   10514471
REFERENCE   10 (residues 1 to 171)
  AUTHORS   Lyu,M.S., Rhee,S.G., Chae,H.Z., Lee,T.H., Adamson,M.C., Kang,S.W.,
            Jin,D.Y., Jeang,K.T. and Kozak,C.A.
  TITLE     Genetic mapping of six mouse peroxiredoxin genes and fourteen
            peroxiredoxin related sequences
  JOURNAL   Mamm Genome 10 (10), 1017-1019 (1999)
   PUBMED   10501973
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120557.12.
            
            Summary: This gene encodes a member of the peroxiredoxin family of
            antioxidant enzymes, which reduce hydrogen peroxide and alkyl
            hydroperoxides. The encoded protein plays an antioxidant protective
            role in different tissues under normal conditions and during
            inflammatory processes. The use of alternate transcription start
            sites may result in use of alternate in-frame translation start
            codons that generate alternate isoforms that are targeted to the
            mitochondrion or peroxisome/cytoplasm. [provided by RefSeq, Nov
            2017].
            
            Transcript Variant: This variant (2) uses an alternate splice site,
            which results in a frameshift, compared to variant 1. The encoded
            isoform (2) has a shorter, distinct C-terminus than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF660397.1, ERR3363660.1075739.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     Protein         1..171
                     /product="peroxiredoxin-5, mitochondrial isoform 2
                     precursor"
                     /EC_number="1.11.1.24"
                     /note="peroxiredoxin-5, mitochondrial; thioredoxin
                     reductase; antioxidant enzyme B166; thioredoxin peroxidase
                     PMP20; peroxisomal antioxidant enzyme; liver tissue
                     2D-page spot 2D-0014IV; peroxiredoxin 6; peroxiredoxin V;
                     peroxisomal membrane protein 20; thioredoxin-dependent
                     peroxiredoxin 5"
                     /calculated_mol_wt=17769
     Region          51..>155
                     /region_name="AHP1"
                     /note="Peroxiredoxin [Posttranslational modification,
                     protein turnover, chaperones]; COG0678"
                     /db_xref="CDD:440442"
     CDS             1..171
                     /gene="Prdx5"
                     /gene_synonym="AOEB166; AOPP; PLP; Pmp20; Prdx6; PrxV"
                     /coded_by="NM_001358444.1:490..1005"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:54683"
                     /db_xref="MGI:MGI:1859821"
ORIGIN      
        1 mlqlglrvlg ckassvlras tclagragrk eagwecggar sfsssavtma pikvgdaips
       61 vevfegepgk kvnlaelfkg kkgvlfgvpg aftpgcskth lpgfveqaga lkakgaqvva
      121 clsvndvfvi eewgrahqae gkvrlladpt gafgktyywm ilwclslgiv g
//
LOCUS       NP_001408091             397 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform p [Mus musculus].
ACCESSION   NP_001408091 XP_006502856
VERSION     NP_001408091.1
DBSOURCE    REFSEQ: accession NM_001421162.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 397)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 397)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 397)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 397)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 397)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 397)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_006502856.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995047.858505.1,
                                           SRR7345562.4499024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..397
                     /product="ELAV-like protein 4 isoform p"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=43568
     Region          60..396
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..397
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421162.1:108..1301"
                     /note="isoform p is encoded by transcript variant 19"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mgllllreiv inesrncsfm iistmepqvs ngptsntsng pssnnrncps pmqtgaatdd
       61 sktnlivnyl pqnmtqeefr slfgsigeie scklvrdkit gqslgygfvn yidpkdaeka
      121 intlnglrlq tktikvsyar pssasirdan lyvsglpktm tqkeleqlfs qygriitsri
      181 lvdqvtgvsr gvgfirfdkr ieaeeaikgl ngqkpsgate pitvkfannp sqkssqalls
      241 qlyqspnrry pgplhhqaqr frldnllnma ygvkrlmsgp vppsacpprf spitidgmts
      301 lvgmnipght gtgwcifvyn lspdsdesvl wqlfgpfgav nnvkvirdfn tnkckgfgfv
      361 tmtnydeaam aiaslngyrl gdrvlqvsfk tnkahks
//
LOCUS       NP_034116               1426 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 1 isoform a [Mus musculus].
ACCESSION   NP_034116 XP_357513
VERSION     NP_034116.3
DBSOURCE    REFSEQ: accession NM_009986.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1426)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 1426)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 1426)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 1426)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1426)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 1426)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Jul 29, 2006 this sequence version replaced NP_034116.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090847.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..1426
                     /product="homeobox protein cut-like 1 isoform a"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=156269
     Region          18..>364
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          456..532
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          656..>839
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          845..913
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1028..1105
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1151..1207
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..1426
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_009986.5:24..4304"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39328.1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 maanvgsmfq ywkrfdlqql qreldatatv lanrqdeseq srkrlieqsr efkkntpedl
       61 rkqvapllks fqgeidalsk rskeaeaafl tvykrlidvp dpvpaldvgq qleikvqrlh
      121 dietenqklr etleeynkef aevknqevti kalkekirey eqtlksqaet ialekeqklq
      181 ndfaekerkl qetqmsttsk leeaehklqt lqtalektrt elfdlktkyd eettakadei
      241 emimtdlera nqraevaqre aetlreqlss anhslqlasq iqkapdveqa ievltrssle
      301 velaakerei aqlvedvqrl qasltklren sasqisqleq qlnaknstlk qleeklkgqa
      361 dyeevkkeln tlksmefaps egagtqdstk plevlllekn rslqsenatl risnsdlsgp
      421 ystnsissps plqqspdvng mapspsqses agsisegeei dtaeiarqvk eqlikhnigq
      481 rifghyvlgl sqgsvseila rpkpwnkltv rgkepfhkmk qflsdeqnil alrsiqgrqr
      541 enpgqslnrl fqevpkrrng segnittrir asetgsdeai ksileqakre lqvqktaepv
      601 qtsstsssgn sddairsilq qarremeaqq aaldpalkpa plsqpdltil tpkhlsaspm
      661 stvstyppla islkktpaap etstaalpsa palkkeaqdv ptldppgsad aaqgvlrpmk
      721 selvrgstwk dpwwspiqpe rrnltsseet kadettasgk eragssqpra ersqlqgpsa
      781 saeywkewps aespysqsse lsltgasrse tpqnsplpss pivpmakpak psvppltpeq
      841 yevymyqevd tieltrqvke klakngicqr ifgekvlgls qgsvsdmlsr pkpwskltqk
      901 grepfirmql wlngelgqgv lpvqgqqqgp vlhsvaslqd plqqgcvsse stpktsascs
      961 papespmsss esvksltelv qqpcpaiets kegkppepsd ppasdsqptt plplsghsal
     1021 siqelvamsp eldtygitkr vkevltdnnl gqrlfgetil gltqgsvsdl larpkpwhkl
     1081 slkgrepfvr mqlwlndpnn veklmdmkrm ekkaymkrrh ssvsdsqpce ppsvgidysq
     1141 gaspqpqhql kkprvvlape ekealkrayq qkpypspkti eelatqlnlk tstvinwfhn
     1201 yrsrirrelf ieeiqagsqg qagasdspsa rssraapsse gdscdgveat daeepggniv
     1261 atksqgglae vaaapadree atqpaekaka qplcsgtpgq ddgedasrpr plpegladap
     1321 apvpslaapa agedaatsat apatateapg aaragpaers salpstsapa naparrpssl
     1381 qslfglpeaa gardnlvrkk kaanlnsiih rlekaasree piewef
//
LOCUS       NP_001345525             197 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 3 [Mus musculus].
ACCESSION   NP_001345525 XP_017169271
VERSION     NP_001345525.1
DBSOURCE    REFSEQ: accession NM_001358596.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 197)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 197)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 197)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 197)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 197)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 197)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 197)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 197)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 197)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 197)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            On Dec 2, 2017 this sequence version replaced XP_017169271.1.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.716208.1,
                                           SRR13422600.1877331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..197
                     /product="autophagy protein 5 isoform 3"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=23004
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1Y0; propagated from
                     UniProtKB/Swiss-Prot (Q99J83.1)"
     Region          79..>160
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..197
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001358596.2:244..837"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mtddkdvlrd vwfgriptcf tlyqdeiter eaepyylllp rvsyltlvtd kvkkhfqkvm
       61 rqedvseiwf eyegtplkwh ypigllfdll asssalpwni tvhfksfpek dllhcpskda
      121 veahfmscmk eadalkhksq vinemqkkdh kqlwmglqnd hdgaafhpea vpacgrrwta
      181 ahtwrspqrs lsfrsrp
//
LOCUS       NP_001396741             751 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 3 [Mus musculus].
ACCESSION   NP_001396741 XP_006505589
VERSION     NP_001396741.1
DBSOURCE    REFSEQ: accession NM_001409812.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 24, 2022 this sequence version replaced XP_006505589.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1366199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..751
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     3"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85789
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          334..527
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          345..431
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            371
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            372
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          564..595
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          614..733
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(618,620..623,625,629,632,634,684..685,688,708,724)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(626..629,646,653,656..657,660,664,667..673,690..694,
                     702,729,731..732)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..694,731)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..693)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(646,653,656..657,660,664,669,671..673,702,729,
                     731..733)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..751
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409812.1:145..2400"
                     /note="isoform 3 is encoded by transcript variant 5"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhrkc
      301 sysfhatpnt ykrkntetal dnkpcgpqcy qhlegakefa aaltaerikt ppkrpggrrr
      361 grlpnnssrp stptisvles kdtdsdreag tetggenndk eeeekkdets ssseansrcq
      421 tpikmkpnie ppenvewsga easmfrvlig tyydnfcaia rligtktcrq vyefrvkess
      481 iiapvptedv dtpprkkkrk hrlwaahcrk iqlkkdgssn hvynyqpcdh prqpcdsscp
      541 cviaqnfcek fcqcssecqn rfpgcrckaq cntkqcpcyl avrecdpdlc ltcgaadhwd
      601 sknvsckncs iqrgskkhll lapsdvagwg ifikdpvqkn efiseycgei isqdeadrrg
      661 kvydkymcsf lfnlnndfvv datrkgnkir fanhsvnpnc yakvmmvngd hrigifakra
      721 iqtgeelffd yrysqadalk yvgieremei p
//
LOCUS       NP_001389917             787 aa            linear   ROD 27-AUG-2025
DEFINITION  peroxisome proliferator-activated receptor gamma coactivator
            1-alpha isoform c [Mus musculus].
ACCESSION   NP_001389917 XP_006503839
VERSION     NP_001389917.1
DBSOURCE    REFSEQ: accession NM_001402988.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 787)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 787)
  AUTHORS   Cai,J.X., Le,A.W., Han,X.Y., Chen,J., Lei,X.H., Huang,C. and
            Zhang,J.V.
  TITLE     Chemerin sustains the growth of spongiotrophoblast and sinusoidal
            trophoblast giant cells through fatty acid oxidation
  JOURNAL   BMC Biol 23 (1), 199 (2025)
   PUBMED   40611253
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 787)
  AUTHORS   Shi,H., Li,J., Li,F., Yu,H., Zhang,F., Wu,T., Yang,L., Li,Y.,
            Hu,R., Chen,M., Sg,N., Zhuang,X., Feng,S., Zhu,L. and Duan,R.
  TITLE     Vitamin C-Dependent Intergenerational Inheritance of Enhanced
            Endurance Performance Following Maternal Exercise
  JOURNAL   Adv Sci (Weinh) 12 (13), e2408912 (2025)
   PUBMED   39921869
REFERENCE   4  (residues 1 to 787)
  AUTHORS   Dumesic,P.A., Wilensky,S.E., Bose,S., Van Vranken,J.G., Gygi,S.P.
            and Spiegelman,B.M.
  TITLE     RBM43 controls PGC1alpha translation and a PGC1alpha-STING
            signaling axis
  JOURNAL   Cell Metab 37 (3), 742-757 (2025)
   PUBMED   39965564
REFERENCE   5  (residues 1 to 787)
  AUTHORS   Wang,Y., Li,X., Liu,C., Zhou,L., Shi,L., Zhang,Z., Chen,L., Gao,M.,
            Gao,L., Xu,Y., Huang,H., Li,J. and Chen,Z.
  TITLE     WTAP regulates postnatal development of brown adipose tissue by
            stabilizing METTL3 in mice
  JOURNAL   Life Metab 1 (3), 270-284 (2022)
   PUBMED   39872074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 787)
  AUTHORS   Kakuma,T., Wang,Z.W., Pan,W., Unger,R.H. and Zhou,Y.T.
  TITLE     Role of leptin in peroxisome proliferator-activated receptor gamma
            coactivator-1 expression
  JOURNAL   Endocrinology 141 (12), 4576-4582 (2000)
   PUBMED   11108270
REFERENCE   7  (residues 1 to 787)
  AUTHORS   Lehman,J.J., Barger,P.M., Kovacs,A., Saffitz,J.E., Medeiros,D.M.
            and Kelly,D.P.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator-1
            promotes cardiac mitochondrial biogenesis
  JOURNAL   J Clin Invest 106 (7), 847-856 (2000)
   PUBMED   11018072
REFERENCE   8  (residues 1 to 787)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   9  (residues 1 to 787)
  AUTHORS   Boss,O., Bachman,E., Vidal-Puig,A., Zhang,C.Y., Peroni,O. and
            Lowell,B.B.
  TITLE     Role of the beta(3)-adrenergic receptor and/or a putative
            beta(4)-adrenergic receptor on the expression of uncoupling
            proteins and peroxisome proliferator-activated receptor-gamma
            coactivator-1
  JOURNAL   Biochem Biophys Res Commun 261 (3), 870-876 (1999)
   PUBMED   10441518
REFERENCE   10 (residues 1 to 787)
  AUTHORS   Puigserver,P., Wu,Z., Park,C.W., Graves,R., Wright,M. and
            Spiegelman,B.M.
  TITLE     A cold-inducible coactivator of nuclear receptors linked to
            adaptive thermogenesis
  JOURNAL   Cell 92 (6), 829-839 (1998)
   PUBMED   9529258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC111037.8, AC158149.3 and
            AC116763.11.
            
            On Mar 24, 2022 this sequence version replaced XP_006503839.1.
            
            Summary: This gene encodes a transcriptional coactivator that
            induces and coordinates gene expression regulating mitochondrial
            biogenesis, respiration, hepatic gluconeogenesis, thermogenic
            program in brown fat and muscle fiber-type switching. Mice lacking
            the encoded protein exhibit reduced thermogenic capacity,
            hyperactivity and resistance to diet-induced obesity. Mice lacking
            the encoded protein specifically in the heart exhibit peripartum
            cardiomyopathy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.50030.1,
                                           SRR7974084.13927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 27.02 cM"
     Protein         1..787
                     /product="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha isoform c"
                     /note="peroxisome proliferator-activated receptor gamma
                     coactivator 1-alpha; PPAR-gamma coactivator 1-alpha"
                     /calculated_mol_wt=89315
     Region          664..754
                     /region_name="RRM_PPARGC1A"
                     /note="RNA recognition motif (RRM) found in peroxisome
                     proliferator-activated receptor gamma coactivator 1-alpha
                     (PGC-1alpha, or PPARGC-1-alpha) and similar proteins;
                     cd12623"
                     /db_xref="CDD:410034"
     CDS             1..787
                     /gene="Ppargc1a"
                     /gene_synonym="A830037N07Rik; Gm11133; PGC-1; Pgc-1alpha;
                     Pgc1; Pgco1; PPARGC-1-alpha; Ppargc1"
                     /coded_by="NM_001402988.1:639..3002"
                     /note="isoform c is encoded by transcript variant 5"
                     /db_xref="GeneID:19017"
                     /db_xref="MGI:MGI:1342774"
ORIGIN      
        1 mdegyfcaal vgedqplcpd lpeldlseld vndldtdsfl gglkwcsdqs eiisnqynne
       61 panifekide eneanllavl tetldslpvd edglpsfdal tdgavttdne aspssmpdgt
      121 pppqeaeeps llkklllapa ntqlsynecs glstqnhaan hthrirtnpa ivktenswsn
      181 kaksicqqqk pqrrpcsell kylttnddpp htkptenrns srdkcaskkk shtqpqsqha
      241 qakpttlslp ltpespndpk gspfenktie rtlsvelsgt agltppttpp hkanqdnpfk
      301 aspklkpsck tvvppptkra rysecsgtqg shstkkgpeq selyaqlsks sglsrgheer
      361 ktkrpslrlf gdhdycqsln sktdilinis qelqdsrqld fkdascdwqg hicsstdsgq
      421 cylretleas kqvspcstrk qlqdqeirae lnkhfghpcq avfddksdkt selrdgdfsn
      481 eqfsklpvfi nsglamdglf ddsedesdkl sypwdgtqpy slfdvspscs sfnspcrdsv
      541 sppkslfsqr pqrmrsrsrs fsrhrscsrs pysrsrsrsp gsrsssrscy yyesshyrhr
      601 thrnsplyvr srsrspysrr prydsyeaye herlkrdeyr kehekreser akqrerqkqk
      661 aieerrviyv gkirpdttrt elrdrfevfg eieectvnlr ddgdsygfit yrytcdafaa
      721 lengytlrrs netdfelyfc grkqffksny adldtnsddf dpastkskyd sldfdsllke
      781 aqrslrr
//
LOCUS       NP_663438                295 aa            linear   ROD 27-AUG-2025
DEFINITION  protein shisa-2 homolog precursor [Mus musculus].
ACCESSION   NP_663438
VERSION     NP_663438.1
DBSOURCE    REFSEQ: accession NM_145463.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 295)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 295)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   3  (residues 1 to 295)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   4  (residues 1 to 295)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   5  (residues 1 to 295)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 295)
  AUTHORS   Johansson,P.A., Irmler,M., Acampora,D., Beckers,J., Simeone,A. and
            Gotz,M.
  TITLE     The transcription factor Otx2 regulates choroid plexus development
            and function
  JOURNAL   Development 140 (5), 1055-1066 (2013)
   PUBMED   23364326
REFERENCE   7  (residues 1 to 295)
  AUTHORS   Goncalves,L., Filipe,M., Marques,S., Salgueiro,A.M., Becker,J.D.
            and Belo,J.A.
  TITLE     Identification and functional analysis of novel genes expressed in
            the Anterior Visceral Endoderm
  JOURNAL   Int J Dev Biol 55 (3), 281-295 (2011)
   PUBMED   21553379
REFERENCE   8  (residues 1 to 295)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (residues 1 to 295)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
  REMARK    GeneRIF: Shisa is antagonistic to Wnt and Fgf signalings
REFERENCE   10 (residues 1 to 295)
  AUTHORS   Filipe,M., Goncalves,L., Bento,M., Silva,A.C. and Belo,J.A.
  TITLE     Comparative expression of mouse and chicken Shisa homologues during
            early development
  JOURNAL   Dev Dyn 235 (9), 2567-2573 (2006)
   PUBMED   16773659
  REMARK    GeneRIF: shisa is expressed throughout embryonic development,
            predominantly in the anterior visceral endoderm, headfolds,
            somites, forebrain, optic vesicle, and limb buds
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY147933.1, AK034905.1 and AA217921.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034905.1, AK087512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.49 cM"
     Protein         1..295
                     /product="protein shisa-2 homolog precursor"
                     /note="transmembrane protein 46; protein shisa-2 homolog;
                     shisa-like protein 2; shisa homolog 2"
                     /calculated_mol_wt=28061
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3423
     mat_peptide     34..295
                     /product="Protein shisa-2 homolog. /id=PRO_0000022616"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZV2.1)"
                     /calculated_mol_wt=28061
     Region          35..211
                     /region_name="Shisa"
                     /note="Wnt and FGF inhibitory regulator; pfam13908"
                     /db_xref="CDD:464036"
     Region          87..108
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZV2.1)"
     Site            111..131
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZV2.1)"
     Region          168..204
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZV2.1)"
     CDS             1..295
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /coded_by="NM_145463.5:787..1674"
                     /db_xref="CCDS:CCDS27173.1"
                     /db_xref="GeneID:219134"
                     /db_xref="MGI:MGI:2444716"
ORIGIN      
        1 mwggrcspst ssrhrasllq lllaallaag arasgeychg wldaqgvwri gfqcperfdg
       61 gdaticcgsc alryccssae arldqggcdn drqqgvgepg rtdregpdss avpiyvpfli
      121 vgsvfvafii lgslvaaccc rclrpkqdpq qsrapganrl metipmipsa stsrgsssrq
      181 sstaasssss ansgarappt rsqtncclpe gtmnnvyvnm ptnfsvlncq qatqivphqg
      241 qylhtpyvgy avqhdsvpmt pvppfmdglq pgyrpvqppf ahtnseqkmf pavtv
//
LOCUS       NP_001371258             147 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin regulatory light chain 2, ventricular/cardiac muscle isoform
            isoform 2 [Mus musculus].
ACCESSION   NP_001371258
VERSION     NP_001371258.1
DBSOURCE    REFSEQ: accession NM_001384329.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Xu,F., Huang,H., Peng,K., Jian,C., Wu,H., Jing,Z., Qiu,S., Chen,Y.,
            Liu,K., Fu,L., Wang,Y., Yang,J., Duan,X., Wang,C., Cheng,H. and
            Wang,X.
  TITLE     ROMO1 overexpression protects the mitochondrial cysteinome from
            oxidations in aging
  JOURNAL   Nat Commun 16 (1), 5133 (2025)
   PUBMED   40461459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Sheikh,F., Lyon,R.C. and Chen,J.
  TITLE     Functions of myosin light chain-2 (MYL2) in cardiac muscle and
            disease
  JOURNAL   Gene 569 (1), 14-20 (2015)
   PUBMED   26074085
  REMARK    Review article
            Erratum:[Gene. 2015 Oct 15;571(1):151]
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Lee,K.F., Simon,H., Chen,H., Bates,B., Hung,M.C. and Hauser,C.
  TITLE     Requirement for neuregulin receptor erbB2 in neural and cardiac
            development
  JOURNAL   Nature 378 (6555), 394-398 (1995)
   PUBMED   7477377
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Lee,K.J., Ross,R.S., Rockman,H.A., Harris,A.N., O'Brien,T.X., van
            Bilsen,M., Shubeita,H.E., Kandolf,R., Brem,G., Price,J. et al.
  TITLE     Myosin light chain-2 luciferase transgenic mice reveal distinct
            regulatory programs for cardiac and skeletal muscle-specific
            expression of a single contractile protein gene
  JOURNAL   J Biol Chem 267 (22), 15875-15885 (1992)
   PUBMED   1379240
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Hastings,K.E. and Emerson,C.P. Jr.
  TITLE     cDNA clone analysis of six co-regulated mRNAs encoding skeletal
            muscle contractile proteins
  JOURNAL   Proc Natl Acad Sci U S A 79 (5), 1553-1557 (1982)
   PUBMED   6951196
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Czosnek,H., Nudel,U., Shani,M., Barker,P.E., Pravtcheva,D.D.,
            Ruddle,F.H. and Yaffe,D.
  TITLE     The genes coding for the muscle contractile proteins, myosin heavy
            chain, myosin light chain 2, and skeletal muscle actin are located
            on three different mouse chromosomes
  JOURNAL   EMBO J 1 (11), 1299-1305 (1982)
   PUBMED   6897916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140353.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.82325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     Protein         1..147
                     /product="myosin regulatory light chain 2,
                     ventricular/cardiac muscle isoform isoform 2"
                     /note="myosin light chain 2v; myosin light chain,
                     phosphorylatable, cardiac ventricles"
                     /calculated_mol_wt=16716
     Region          1..141
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..147
                     /gene="Myl2"
                     /gene_synonym="Gm32672; MLC-2; MLC-2s/v; MLC-2v; Mlc2v;
                     Mylpc"
                     /coded_by="NM_001384329.1:893..1336"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /db_xref="GeneID:17906"
                     /db_xref="MGI:MGI:97272"
ORIGIN      
        1 mfeqtqiqef keaftimdqn rdgfidkndl rdtfaalgrv nvkneeidem ikeapgpinf
       61 tvfltmfgek lkgadpeeti lnafkvfdpe gkgslkadyv remlttqaer fskeeidqmf
      121 aafppdvtgn ldyknlvhii thgeekd
//
LOCUS       NP_032171                 90 aa            linear   ROD 27-AUG-2025
DEFINITION  progonadoliberin-1 isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_032171
VERSION     NP_032171.1
DBSOURCE    REFSEQ: accession NM_008145.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 90)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 90)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 90)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   4  (residues 1 to 90)
  AUTHORS   Barelle,P.Y., Sicardi,A., Schaller,F., Buron,J., Becquet,D.,
            Omnes,F., Watrin,F., Alifrangis,M.S., Santos,C., Menuet,C.,
            Francois-Bellan,A.M., Caron,E., Klucznik,J., Prevot,V., Bouret,S.G.
            and Muscatelli,F.
  TITLE     Investigation of a mouse model of Prader-Willi Syndrome with
            combined disruption of Necdin and Magel2
  JOURNAL   JCI Insight 10 (8), e185159 (2025)
   PUBMED   40048253
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 90)
  AUTHORS   Zouaghi,Y., Alpern,D., Gardeux,V., Russeil,J., Deplancke,B.,
            Santoni,F., Pitteloud,N. and Messina,A.
  TITLE     Transcriptomic profiling of murine GnRH neurons reveals
            developmental trajectories linked to human reproduction and
            infertility
  JOURNAL   Theranostics 15 (8), 3673-3692 (2025)
   PUBMED   40093908
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 90)
  AUTHORS   Silverman,A.J., Roberts,J.L., Dong,K.W., Miller,G.M. and
            Gibson,M.J.
  TITLE     Intrahypothalamic injection of a cell line secreting
            gonadotropin-releasing hormone results in cellular differentiation
            and reversal of hypogonadism in mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10668-10672 (1992)
   PUBMED   1438263
REFERENCE   7  (residues 1 to 90)
  AUTHORS   Livne,I., Silverman,A.J. and Gibson,M.J.
  TITLE     Reversal of reproductive deficiency in the hpg male mouse by
            neonatal androgenization
  JOURNAL   Biol Reprod 47 (4), 561-567 (1992)
   PUBMED   1391342
REFERENCE   8  (residues 1 to 90)
  AUTHORS   Scott,I.S., Bennett,M.K., Porter-Goff,A.E., Harrison,C.J.,
            Cox,B.S., Grocock,C.A., O'Shaughnessy,P.J., Clayton,R.N.,
            Craven,R., Furr,B.J. et al.
  TITLE     Effects of the gonadotrophin-releasing hormone agonist 'Zoladex'
            upon pituitary and gonadal function in hypogonadal (hpg) male mice:
            a comparison with normal male and testicular feminized (tfm) mice
  JOURNAL   J Mol Endocrinol 8 (3), 249-258 (1992)
   PUBMED   1385960
REFERENCE   9  (residues 1 to 90)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (residues 1 to 90)
  AUTHORS   Cattanach,B.M., Iddon,C.A., Charlton,H.M., Chiappa,S.A. and Fink,G.
  TITLE     Gonadotrophin-releasing hormone deficiency in a mutant mouse with
            hypogonadism
  JOURNAL   Nature 269 (5626), 338-340 (1977)
   PUBMED   198666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093020.6.
            
            Summary: This gene encodes hypophysiotropic peptides belonging to
            the family of gonadotropin-releasing hormones that stimulate the
            release of gonadotropins and suppress secretion of prolactin from
            the pituitary gland. The encoded protein is proteolytically
            processed to generate two biologically active mature peptides. A
            deletional mutation encompassing the distal half of this gene in
            mice resulting in the loss of the encoded protein leads to
            hypogonadism and infertility. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ059442.1, AK139480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..90
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.66 cM"
     Protein         1..90
                     /product="progonadoliberin-1 isoform 1 preproprotein"
                     /note="gonadotropin releasing hormone 2; progonadoliberin
                     I; luteinizing hormone-releasing hormone I"
                     /calculated_mol_wt=8146
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2209
     mat_peptide     22..90
                     /product="Progonadoliberin-1. /id=PRO_0000012404"
                     /note="propagated from UniProtKB/Swiss-Prot (P13562.1)"
                     /calculated_mol_wt=8146
     mat_peptide     22..31
                     /product="Gonadoliberin-1. /id=PRO_0000012405"
                     /note="propagated from UniProtKB/Swiss-Prot (P13562.1)"
                     /calculated_mol_wt=1200
     Site            22
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:P01148; propagated from
                     UniProtKB/Swiss-Prot (P13562.1)"
     Site            24..25
                     /site_type="cleavage"
                     /note="Cleavage, by ACE.
                     /evidence=ECO:0000250|UniProtKB:P01148; propagated from
                     UniProtKB/Swiss-Prot (P13562.1)"
     Site            24
                     /site_type="other"
                     /note="Appears to be essential for biological activity;
                     propagated from UniProtKB/Swiss-Prot (P13562.1)"
     Site            26..27
                     /site_type="cleavage"
                     /note="Cleavage, by ACE.
                     /evidence=ECO:0000250|UniProtKB:P01148; propagated from
                     UniProtKB/Swiss-Prot (P13562.1)"
     Site            28..29
                     /site_type="cleavage"
                     /note="Cleavage, by ACE.
                     /evidence=ECO:0000250|UniProtKB:P01148; propagated from
                     UniProtKB/Swiss-Prot (P13562.1)"
     Site            31..32
                     /site_type="cleavage"
                     /note="Cleavage, by ACE.
                     /evidence=ECO:0000250|UniProtKB:P01148; propagated from
                     UniProtKB/Swiss-Prot (P13562.1)"
     Site            31
                     /site_type="amidation"
                     /note="Glycine amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P13562.1)"
     mat_peptide     35..90
                     /product="Prolactin release-inhibiting factor 1.
                     /id=PRO_0000012406"
                     /note="propagated from UniProtKB/Swiss-Prot (P13562.1)"
                     /calculated_mol_wt=6622
     CDS             1..90
                     /gene="Gnrh1"
                     /gene_synonym="Gnrh; Gnrh2; hpg; LHRH; Lhrh1; Lnrh"
                     /coded_by="NM_008145.4:66..338"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS27231.1"
                     /db_xref="GeneID:14714"
                     /db_xref="MGI:MGI:95789"
ORIGIN      
        1 milklmagil lltvclegcs sqhwsyglrp ggkrntehlv esfqemgkev dqmaepqhfe
       61 ctvhwprspl rdlrgalesl ieeearqkkm
//
LOCUS       NP_001412525             644 aa            linear   ROD 27-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform 6 [Mus
            musculus].
ACCESSION   NP_001412525 XP_006518495
VERSION     NP_001412525.1
DBSOURCE    REFSEQ: accession NM_001425596.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 644)
  AUTHORS   He,W., Marchuk,H., Koeberl,D., Kasumov,T., Chen,X. and Zhang,G.F.
  TITLE     Fasting alleviates metabolic alterations in mice with propionyl-CoA
            carboxylase deficiency due to Pcca mutation
  JOURNAL   Commun Biol 7 (1), 659 (2024)
   PUBMED   38811689
  REMARK    GeneRIF: Fasting alleviates metabolic alterations in mice with
            propionyl-CoA carboxylase deficiency due to Pcca mutation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 644)
  AUTHORS   Soria,L.R., Makris,G., D'Alessio,A.M., De Angelis,A., Boffa,I.,
            Pravata,V.M., Rufenacht,V., Attanasio,S., Nusco,E., Arena,P.,
            Ferenbach,A.T., Paris,D., Cuomo,P., Motta,A., Nitzahn,M.,
            Lipshutz,G.S., Martinez-Pizarro,A., Richard,E., Desviat,L.R.,
            Haberle,J., van Aalten,D.M.F. and Brunetti-Pierri,N.
  TITLE     O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and
            promotes ureagenesis
  JOURNAL   Nat Commun 13 (1), 5212 (2022)
   PUBMED   36064721
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 644)
  AUTHORS   Subramanian,C., Frank,M.W., Tangallapally,R., Yun,M.K., Edwards,A.,
            White,S.W., Lee,R.E., Rock,C.O. and Jackowski,S.
  TITLE     Pantothenate kinase activation relieves coenzyme A sequestration
            and improves mitochondrial function in mice with propionic acidemia
  JOURNAL   Sci Transl Med 13 (611), eabf5965 (2021)
   PUBMED   34524863
REFERENCE   5  (residues 1 to 644)
  AUTHORS   Jiang,L., Park,J.S., Yin,L., Laureano,R., Jacquinet,E., Yang,J.,
            Liang,S., Frassetto,A., Zhuo,J., Yan,X., Zhu,X., Fortucci,S.,
            Hoar,K., Mihai,C., Tunkey,C., Presnyak,V., Benenato,K.E.,
            Lukacs,C.M., Martini,P.G.V. and Guey,L.T.
  TITLE     Dual mRNA therapy restores metabolic function in long-term studies
            in mice with propionic acidemia
  JOURNAL   Nat Commun 11 (1), 5339 (2020)
   PUBMED   33087718
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 644)
  AUTHORS   Guenzel,A.J., Hofherr,S.E., Hillestad,M., Barry,M., Weaver,E.,
            Venezia,S., Kraus,J.P., Matern,D. and Barry,M.A.
  TITLE     Generation of a hypomorphic model of propionic acidemia amenable to
            gene therapy testing
  JOURNAL   Mol Ther 21 (7), 1316-1323 (2013)
   PUBMED   23648696
REFERENCE   7  (residues 1 to 644)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (residues 1 to 644)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 644)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 644)
  AUTHORS   Miyazaki,T., Ohura,T., Kobayashi,M., Shigematsu,Y., Yamaguchi,S.,
            Suzuki,Y., Hata,I., Aoki,Y., Yang,X., Minjares,C., Haruta,I.,
            Uto,H., Ito,Y. and Muller,U.
  TITLE     Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase
            and its rescue by postnatal, liver-specific supplementation via a
            transgene
  JOURNAL   J Biol Chem 276 (38), 35995-35999 (2001)
   PUBMED   11461925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154683.2, AC169511.1 and AC154499.2.
            
            On Nov 22, 2023 this sequence version replaced XP_006518495.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2145441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.99 cM"
     Protein         1..644
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform 6"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase alpha chain,
                     mitochondrial; propanoyl-CoA:carbon dioxide ligase subunit
                     alpha; propionyl CoA-carboxylase alpha; PCCase subunit
                     alpha"
                     /calculated_mol_wt=70605
     CDS             1..644
                     /gene="Pcca"
                     /coded_by="NM_001425596.1:237..2171"
                     /note="isoform 6 is encoded by transcript variant 7"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
ORIGIN      
        1 mgiktvaihs dvdassvhvk madeavcvgp aptsksylnm daimeaikkt raqavhpgyg
       61 flsenkefak rlaaedvtfi gpdthaiqam gdkiesklla krakvntipg fdgvvkdade
      121 avriareigy pvmikasagg ggkgmriawd deetrdgfrf ssqeaassfg ddrlliekfi
      181 dnprhieiqv lgdkhgnalw lnerecsiqr rnqkvveeap sifldpetrq amgeqavala
      241 kavkyssagt veflvdsqkn fyflemntrl qvehpvteci tgldlvqemi lvakgyplrh
      301 kqedipisgw avecrvyaed pyksfglpsi grlsqyqepi hlpgvrvdsg iqpgsdisiy
      361 ydpmisklvt ygsdraealk rmedaldnyv irgvthnipl lreviintrf vkgdistkfl
      421 sdvypdgfkg htltlsernq llaiassvfv asqlraqrfq ehsrvpvirp dvakwelsvk
      481 lhdedhtvva snngpaftve vdgsklnvts twnlasplls vnvdgtqrtv qclsreaggn
      541 msiqflgtvy kvhiltklaa elnkfmlekv pkdtsstlcs pmpgvvvavs vkpgdmvaeg
      601 qeicvieamk mqnsmtagkm gkvklvhcka gdtvgegdll vele
//
LOCUS       NP_034021                645 aa            linear   ROD 27-AUG-2025
DEFINITION  choline O-acetyltransferase [Mus musculus].
ACCESSION   NP_034021
VERSION     NP_034021.1
DBSOURCE    REFSEQ: accession NM_009891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 645)
  AUTHORS   Liu,Y.A., Nong,Y., Feng,J., Li,G., Sajda,P., Li,Y. and Wang,Q.
  TITLE     Phase synchrony between prefrontal noradrenergic and cholinergic
            signals indexes inhibitory control
  JOURNAL   Nat Commun 16 (1), 7260 (2025)
   PUBMED   40770025
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 645)
  AUTHORS   Monical,A. and McGehee,D.S.
  TITLE     Nicotine Withdrawal Drives Aversive Behaviors by Recruiting
            Inhibitory Interpeduncular Nucleus Inputs to the Laterodorsal
            Tegmentum in Mice
  JOURNAL   J Neurosci 45 (32), e2405242025 (2025)
   PUBMED   40659528
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 645)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   4  (residues 1 to 645)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 645)
  AUTHORS   Foote,A.G. and Sun,X.
  TITLE     Cellular heterogeneity and patterning strategies as revealed by
            upper respiratory epithelium single cell atlas
  JOURNAL   iScience 28 (7), 112845 (2025)
   PUBMED   40612507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 645)
  AUTHORS   Motwani,M., White,R.A., Guo,N., Dowler,L.L., Tauber,A.I. and
            Sastry,K.N.
  TITLE     Mouse surfactant protein-D. cDNA cloning, characterization, and
            gene localization to chromosome 14
  JOURNAL   J Immunol 155 (12), 5671-5677 (1995)
   PUBMED   7499852
REFERENCE   7  (residues 1 to 645)
  AUTHORS   Schneider-Maunoury,S., Topilko,P., Seitandou,T., Levi,G.,
            Cohen-Tannoudji,M., Pournin,S., Babinet,C. and Charnay,P.
  TITLE     Disruption of Krox-20 results in alteration of rhombomeres 3 and 5
            in the developing hindbrain
  JOURNAL   Cell 75 (6), 1199-1214 (1993)
   PUBMED   7903221
REFERENCE   8  (residues 1 to 645)
  AUTHORS   Misawa,H., Ishii,K. and Deguchi,T.
  TITLE     Gene expression of mouse choline acetyltransferase. Alternative
            splicing and identification of a highly active promoter region
  JOURNAL   J Biol Chem 267 (28), 20392-20399 (1992)
   PUBMED   1400357
REFERENCE   9  (residues 1 to 645)
  AUTHORS   Whitlon,D.S. and Rutishauser,U.S.
  TITLE     NCAM in the organ of Corti of the developing mouse
  JOURNAL   J Neurocytol 19 (6), 970-977 (1990)
   PUBMED   2292721
REFERENCE   10 (residues 1 to 645)
  AUTHORS   Ishii,K., Oda,Y., Ichikawa,T. and Deguchi,T.
  TITLE     Complementary DNAs for choline acetyltransferase from spinal cords
            of rat and mouse: nucleotide sequences, expression in mammalian
            cells, and in situ hybridization
  JOURNAL   Brain Res Mol Brain Res 7 (2), 151-159 (1990)
   PUBMED   2160042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046406.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046406.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     Protein         1..645
                     /product="choline O-acetyltransferase"
                     /EC_number="2.3.1.6"
                     /note="choline acetylase; choline acetyltransferase"
                     /calculated_mol_wt=72208
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P32738; propagated from
                     UniProtKB/Swiss-Prot (Q03059.2)"
     Region          27..604
                     /region_name="Carn_acyltransf"
                     /note="Choline/Carnitine o-acyltransferase; pfam00755"
                     /db_xref="CDD:459926"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P32738; propagated from
                     UniProtKB/Swiss-Prot (Q03059.2)"
     CDS             1..645
                     /gene="Chat"
                     /gene_synonym="B230380D24Rik; CHOACTase"
                     /coded_by="NM_009891.2:331..2268"
                     /db_xref="CCDS:CCDS26920.1"
                     /db_xref="GeneID:12647"
                     /db_xref="MGI:MGI:88392"
ORIGIN      
        1 mpilekvppk mpvqasscee vldlpklpvp plqqtlatyl qcmqhlvpee qfrksqaivk
       61 rfgapgglge tlqekllerq ektanwvsey wlndmylnnr lalpvnsspa vifarqhfqd
      121 tndqlrfaas lisgvlsyka lldsqsiptd wakgqlsgqp lcmkqyyrlf ssyrlpghtq
      181 dtlvaqkssi mpepehviva ccnqffvldv vinfrrlseg dlftqlrkiv kmasnederl
      241 ppiglltsdg rsewakartv llkdstnrds ldmiercicl vcldgpgtgd lsdthralql
      301 lhgggcslng anrwydkslq fvvgrdgtcg vvcehspfdg ivlvqctehl lkhmmtgnkk
      361 lvradsvsel paprrlrwkc spetqghlas saeklqrivk nldfivykfd nygktfikkq
      421 kcspdgfiqv alqlayyrly qrlvptyesa sirrfqegrv dnirsatpea lafvqamtdh
      481 kaavlasekl qllqraiqaq teytvmaitg maidnhllal relardlcke ppemfmdety
      541 lmsnrfilst sqvpttmemf ccygpvvpng ygacynpqpe aitfcissfh gcketssvef
      601 aeavgaslvd mrdlcssrqp aegkpptake rargptkpsn ldysh
//
LOCUS       NP_001411816             422 aa            linear   ROD 27-AUG-2025
DEFINITION  TGF-beta receptor type-1 isoform 5 precursor [Mus musculus].
ACCESSION   NP_001411816
VERSION     NP_001411816.1
DBSOURCE    REFSEQ: accession NM_001424887.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Ware,K., Peter,J., McClain,L. and Luo,Y.
  TITLE     Cell type-dependent role of transforming growth factor-beta
            signaling on postnatal neural stem cell proliferation and migration
  JOURNAL   Neural Regen Res 21 (3), 1151-1161 (2026)
   PUBMED   39885664
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Tang,Q., Li,L., Li,Y., Wang,A., Li,H., Wang,L., Gu,C., Lee,J.M.,
            Wu,Z., Kwon,H.E. and Chen,Y.
  TITLE     Distinct BMP-Smad signaling outputs confer diverse functions in
            dental mesenchyme
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40446216
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Sugimoto,A., Saito,Y., Wang,G., Sun,Q., Yin,C., Lee,K.H., Geng,Y.,
            Rajbhandari,P., Hernandez,C., Steffani,M., Qie,J., Savage,T.,
            Goyal,D.M., Ray,K.C., Neelakantan,T.V., Yin,D., Melms,J.,
            Lehrich,B.M., Yasaka,T.M., Liu,S., Oertel,M., Lan,T., Guillot,A.,
            Peiseler,M., Filliol,A., Kanzaki,H., Fujiwara,N., Ravi,S., Izar,B.,
            Brosch,M., Hampe,J., Remotti,H., Argemi,J., Sun,Z., Kendall,T.J.,
            Hoshida,Y., Tacke,F., Fallowfield,J.A., Blockley-Powell,S.K.,
            Haeusler,R.A., Steinman,J.B., Pajvani,U.B., Monga,S.P.,
            Bataller,R., Masoodi,M., Arpaia,N., Lee,Y.A., Stockwell,B.R.,
            Augustin,H.G. and Schwabe,R.F.
  TITLE     Hepatic stellate cells control liver zonation, size and functions
            via R-spondin 3
  JOURNAL   Nature 640 (8059), 752-761 (2025)
   PUBMED   40074890
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Wang,X., Zhao,X., Zheng,X., Peng,X., Chen,J., Wang,Y., Wang,Z.,
            Meng,M. and Du,J.
  TITLE     Sirt6 loss activates Got1 and facilitates cleft palate through
            abnormal activating glycolysis
  JOURNAL   Cell Death Dis 16 (1), 159 (2025)
   PUBMED   40050262
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Lozovska,A., Casaca,A., Novoa,A., Kuo,Y.Y., Jurberg,A.D.,
            Martins,G.G., Hadjantonakis,A.K. and Mallo,M.
  TITLE     Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization
            during the trunk to tail transition
  JOURNAL   Elife 13, 94290 (2025)
   PUBMED   39874182
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Iseki,S., Osumi-Yamashita,N., Miyazono,K., Franzen,P., Ichijo,H.,
            Ohtani,H., Hayashi,Y. and Eto,K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (residues 1 to 422)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Suzuki,A., Shioda,N., Maeda,T., Tada,M. and Ueno,N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772232.18 and AL772150.11.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.26247765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     Protein         1..422
                     /product="TGF-beta receptor type-1 isoform 5 precursor"
                     /EC_number="2.7.11.30"
                     /note="TGF-beta receptor type-1; TGF-beta receptor type I;
                     transforming growth factor-beta receptor type I"
                     /calculated_mol_wt=44626
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2885
     Region          30..104
                     /region_name="TFP_LU_ECD_ALK5"
                     /note="extracellular domain (ECD) found in activin
                     receptor-like kinase 5 (ALK-5) and similar proteins;
                     cd23537"
                     /db_xref="CDD:467067"
     Site            41
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64729.1)"
     Region          <110..122
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:462503"
     Region          128..415
                     /region_name="STKc_TGFbR1_ACVR1b_ACVR1c"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Transforming Growth Factor beta Type I Receptor and
                     Activin Type IB/IC Receptors; cd14143"
                     /db_xref="CDD:271045"
     Site            order(130..134,138,149,151,179,199..202,206,208,252,254,
                     256..257,259,270,273,293..296)
                     /site_type="active"
                     /db_xref="CDD:271045"
     Site            order(130..136,138,149,151,199..200,202,206,256..257,259,
                     270)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271045"
     Site            order(134,206,208,252,254,256,273,293..296)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271045"
     Site            order(161..162,165..166,169..170,184,186)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271045"
     Site            269..296
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271045"
     CDS             1..422
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /coded_by="NM_001424887.1:55..1323"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
ORIGIN      
        1 meaaaaaprr pqllivlvaa atllpgakal qcfchlctkd nftcetdglc fvsvtettdk
       61 vihnsmciae idliprdrpf vcapssktga vtttyccnqd hcnkielptt glpllvqrti
      121 artivlqesi gkgrfgevwr gkwrgeevav kifssreers wfreaeiyqt vmlrhenilg
      181 fiaadnkdng twtqlwlvsd yhehgslfdy lnrytvtveg miklalstas glahlhmeiv
      241 gtqgkpaiah rdlksknilv kkngtcciad lglavrhdsa tdtidiapnh rvgtkrymap
      301 evlddsinmk hfesfkradi yamglvfwei arrcsiggih edyqlpyydl vpsdpsveem
      361 rkvvceqklr pnipnrwqsc ealrvmakim recwyangaa rltalrikkt lsqlsqqegi
      421 km
//
LOCUS       NP_001171257             498 aa            linear   ROD 27-AUG-2025
DEFINITION  CD44 antigen isoform e precursor [Mus musculus].
ACCESSION   NP_001171257
VERSION     NP_001171257.1
DBSOURCE    REFSEQ: accession NM_001177786.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 498)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   2  (residues 1 to 498)
  AUTHORS   Deobald,K.N., Steele,S.P., Dominguez,S.R., Whiles,S. and Kawula,T.
  TITLE     Merocytophagy is an integrin-stabilized macrophage response to
            microbes reliant on Syk signaling
  JOURNAL   Front Immunol 16, 1565250 (2025)
   PUBMED   40313956
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 498)
  AUTHORS   Zhang,C., Huang,Q., Ford,N.C., Limjunyawong,N., Lin,Q., Yang,F.,
            Cui,X., Uniyal,A., Liu,J., Mahabole,M., He,H., Wang,X., Duff,I.,
            Wang,Y., Wan,J., Zhu,G., Raja,S.N., Jia,H., Yang,D., Dong,X.,
            Cao,X., Tseng,S.C., He,S. and Guan,Y.
  TITLE     Human birth tissue products as a non-opioid medicine to inhibit
            post-surgical pain
  JOURNAL   Elife 13, 101269 (2024)
   PUBMED   39671234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 498)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (residues 1 to 498)
  AUTHORS   Araujo David,B., Atif,J., Vargas E Silva Castanheira,F., Yasmin,T.,
            Guillot,A., Ait Ahmed,Y., Peiseler,M., Hommes,J.W., Salm,L.,
            Brundler,M.A., Surewaard,B.G.J., Elhenawy,W., MacParland,S.,
            Ginhoux,F., McCoy,K. and Kubes,P.
  TITLE     Kupffer cell reverse migration into the liver sinusoids mitigates
            neonatal sepsis and meningitis
  JOURNAL   Sci Immunol 9 (101), eadq9704 (2024)
   PUBMED   39485859
REFERENCE   6  (residues 1 to 498)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   7  (residues 1 to 498)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 498)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   9  (residues 1 to 498)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   10 (residues 1 to 498)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844155.6, AK045226.1 and AJ251594.1.
            
            Transcript Variant: This variant (5) lacks several alternate,
            in-frame, exons, compared to variant 1. The resulting protein
            (isoform e) is shorter when it is compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66082.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     Protein         1..498
                     /product="CD44 antigen isoform e precursor"
                     /note="PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; lymphocyte antigen 24; phagocytic
                     glycoprotein 1; extracellular matrix receptor III; GP90
                     lymphocyte homing/adhesion receptor; phagocytic
                     glycoprotein I"
                     /calculated_mol_wt=51860
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2420
     Region          30..173
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(42,45..46,72,82..83,104..105,109)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     CDS             1..498
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /coded_by="NM_001177786.1:320..1816"
                     /note="isoform e precursor is encoded by transcript
                     variant 5"
                     /db_xref="CCDS:CCDS50649.1"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
ORIGIN      
        1 mdkfwwhtaw glcllqlsla hphqqidlnv tcryagvfhv ekngrysisr teaadlcqaf
       61 nstlptmdqm klalskgfet crygfiegnv viprihpnai caanhtgvyi lvtsntshyd
      121 tycfnasapp eedctsvtdl pnsfdgpvti tivnrdgtry skkgeyrthq edidasniid
      181 ddvssgstie kstpesyilh tylpteqptg dqddsffirs tlatntdssh sttlqptaap
      241 nthlvedlnr tgplsvttpq shsqnfstlh gepeedenhp ttsilpsstk sgakdarrgg
      301 slptdtttsv egytfqypdt mengtlfpvt paktevfget evtlatdsnv nvdgslpgdr
      361 dsskdsrgss rtvthgsela ghssanqdsg vtttsgpmrr pqipewliil asllalalil
      421 avciavnsrr rcgqkkklvi nggngtvedr kpselngeas ksqemvhlvn kepsetpdqc
      481 mtadetrnlq svdmkigv
//
LOCUS       NP_001390029             308 aa            linear   ROD 27-AUG-2025
DEFINITION  fibroblast growth factor 8 isoform 7 precursor [Mus musculus].
ACCESSION   NP_001390029 XP_036017324
VERSION     NP_001390029.1
DBSOURCE    REFSEQ: accession NM_001403100.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 308)
  AUTHORS   Zhang,Z., Yu,Z., Chong,Y., Liu,Y., Liu,J., Ren,W., Xu,S. and
            Yang,G.
  TITLE     Evolution of cetacean-specific conserved non-coding elements
            suggests their role in the limb changes during secondary aquatic
            adaptation
  JOURNAL   BMC Biol 23 (1), 216 (2025)
   PUBMED   40670992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 308)
  AUTHORS   Glaser,J., Cova,G., Fauler,B., Prada-Medina,C.A., Stanislas,V.,
            Phan,M.H.Q., Schopflin,R., Aktas,Y., Franke,M., Andrey,G.,
            Bartzoka,N., Paliou,C., Laupert,V., Chan,W.L., Wittler,L.,
            Mielke,T. and Mundlos,S.
  TITLE     Enhancer adoption by an LTR retrotransposon generates viral-like
            particles, causing developmental limb phenotypes
  JOURNAL   Nat Genet 57 (7), 1766-1776 (2025)
   PUBMED   40634706
REFERENCE   3  (residues 1 to 308)
  AUTHORS   Wu,S., Bian,Y., Zhang,C., Liu,K., Sun,F., Chen,E., Zhou,C., Yu,L.,
            Chen,G. and Wu,M.
  TITLE     Merlin controls limb development and thumb formation by regulating
            primary cilium-hedgehog signaling
  JOURNAL   Cell Rep 44 (6), 115849 (2025)
   PUBMED   40503937
REFERENCE   4  (residues 1 to 308)
  AUTHORS   Huang,Y., Tsang,S.W., Tsang,W.H. and Chow,K.L.
  TITLE     Mab21l2 is required to promote cell proliferation in stylopods
            during early limb development
  JOURNAL   Biochem Biophys Res Commun 756, 151534 (2025)
   PUBMED   40054064
  REMARK    Erratum:[Biochem Biophys Res Commun. 2025 May 26;760:151679. doi:
            10.1016/j.bbrc.2025.151679. PMID: 40157810]
REFERENCE   5  (residues 1 to 308)
  AUTHORS   Wang,S. and Zheng,Z.
  TITLE     Differences in Formation of Prepuce and Urethral Groove During
            Penile Development Between Guinea Pigs and Mice Are Controlled by
            Differential Expression of Shh, Fgf10 and Fgfr2
  JOURNAL   Cells 14 (5), 348 (2025)
   PUBMED   40072077
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 308)
  AUTHORS   Chan,D.C., Wynshaw-Boris,A. and Leder,P.
  TITLE     Formin isoforms are differentially expressed in the mouse embryo
            and are required for normal expression of fgf-4 and shh in the limb
            bud
  JOURNAL   Development 121 (10), 3151-3162 (1995)
   PUBMED   7588050
REFERENCE   7  (residues 1 to 308)
  AUTHORS   Mahmood,R., Bresnick,J., Hornbruch,A., Mahony,C., Morton,N.,
            Colquhoun,K., Martin,P., Lumsden,A., Dickson,C. and Mason,I.
  TITLE     A role for FGF-8 in the initiation and maintenance of vertebrate
            limb bud outgrowth
  JOURNAL   Curr Biol 5 (7), 797-806 (1995)
   PUBMED   7583127
REFERENCE   8  (residues 1 to 308)
  AUTHORS   Tanaka,A., Miyamoto,K., Matsuo,H., Matsumoto,K. and Yoshida,H.
  TITLE     Human androgen-induced growth factor in prostate and breast cancer
            cells: its molecular cloning and growth properties
  JOURNAL   FEBS Lett 363 (3), 226-230 (1995)
   PUBMED   7737407
REFERENCE   9  (residues 1 to 308)
  AUTHORS   Mattei,M.G., deLapeyriere,O., Bresnick,J., Dickson,C., Birnbaum,D.
            and Mason,I.
  TITLE     Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth
            factor 8) genes map to chromosomes 2 and 19 respectively
  JOURNAL   Mamm Genome 6 (3), 196-197 (1995)
   PUBMED   7749227
REFERENCE   10 (residues 1 to 308)
  AUTHORS   Tanaka,A., Miyamoto,K., Minamino,N., Takeda,M., Sato,B., Matsuo,H.
            and Matsumoto,K.
  TITLE     Cloning and characterization of an androgen-induced growth factor
            essential for the androgen-dependent growth of mouse mammary
            carcinoma cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8928-8932 (1992)
   PUBMED   1409588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149086.4.
            
            On Mar 28, 2022 this sequence version replaced XP_036017324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     Protein         1..308
                     /product="fibroblast growth factor 8 isoform 7 precursor"
                     /note="androgen-induced growth factor; heparin-binding
                     growth factor 8; fibroblast growth factor 6c"
                     /calculated_mol_wt=31702
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2809
     Region          125..271
                     /region_name="beta-trefoil_FGF8"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 8 (FGF8) and similar proteins; cd23322"
                     /db_xref="CDD:467008"
     Site            order(125,128..129,132,137,139..141,143..145,150,152,155,
                     157,181..183,185..188,190,224,226..228,230..232,248,
                     268..271)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:467008"
     CDS             1..308
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /coded_by="NM_001403100.1:211..1137"
                     /note="isoform 7 precursor is encoded by transcript
                     variant 7"
                     /db_xref="GeneID:14179"
                     /db_xref="MGI:MGI:99604"
ORIGIN      
        1 mgsprsalsc lllhllvlcl qaqvrsaaqk rgpgagnpad tlgqghedrp fgqrsragkn
       61 ftnpapnype egskeqrdsv lpkvtqregp gggpalgrep tsllragrep qgvsqqvtvq
      121 sspnftqhvr eqslvtdqls rrlirtyqly srtsgkhvqv lankrinama edgdpfakli
      181 vetdtfgsrv rvrgaetgly icmnkkgkli aksngkgkdc vfteivlenn ytalqnakye
      241 gwymaftrkg rprkgsktrq hqrevhfmkr lprghhtteq slrfeflnyp pftrslrgsq
      301 rtwapepr
//
LOCUS       NP_001405739             165 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 6 [Mus musculus].
ACCESSION   NP_001405739
VERSION     NP_001405739.1
DBSOURCE    REFSEQ: accession NM_001418810.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 165)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 165)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 165)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 165)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 165)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 165)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 165)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 165)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 165)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 165)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.458585.1,
                                           SRR17253012.6833136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..165
                     /product="COMM domain-containing protein 10 isoform 6"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=18431
     Region          15..164
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..165
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418810.1:39..536"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 maasaalilp espsmkkavp linaidtgrf prllsrilqk lhlkavyhnv kpaalqqqle
       61 mihlrkdkae afasawsamg qetvekfrqr ilgphkletv gwqlnlqmah saqaklqspq
      121 avlqlgvske daknvekvlv efnhkelfdf ynkletiqaq ldslt
//
LOCUS       NP_001186276             429 aa            linear   ROD 27-AUG-2025
DEFINITION  forkhead box protein P3 [Mus musculus].
ACCESSION   NP_001186276
VERSION     NP_001186276.1
DBSOURCE    REFSEQ: accession NM_001199347.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 429)
  AUTHORS   Pignata,A., Frieser,D., Gonzalez-Fierro,C., Hsiao,C.C.,
            Engelenburg,H.J., Alis,M., Fijalkow,I., Cazaentre,V., Nozeran,L.,
            Miranda-Capet,R., Dufourd,E., Vermeulen,T., Aida,A., Le Coz,C., Van
            Gisbergen,K., Blanchard,N., Hamann,J., Smolders,J., Liblau,R.S. and
            Masson,F.
  TITLE     Tissue-resident memory CD4+ T cells infiltrate the CNS in
            progressive multiple sclerosis and contribute to chronic
            autoimmunity in mice
  JOURNAL   Sci Transl Med 17 (808), eadp8109 (2025)
   PUBMED   40700520
REFERENCE   2  (residues 1 to 429)
  AUTHORS   Kohne,M., Shakiba,M.H., Schmidleithner,L., Schulte-Schrepping,J.,
            Scholz,R., Elmzzahi,T., Sommer,D., Li,Y., Carraro,C., De
            Domenico,E., Wissfeld,J., Handler,K., Hamada,D., Frolov,A.,
            Cheng,X., Baumgart,A.K., Holsten,L., Osei-Sarpong,C., Bourry,S.,
            Thabet,Y., Renken,H., Paulusch,S., Sadlon,T., Buch,T.,
            Wunderlich,F.T., Wickenhauser,C., Alferink,J., Kuhlmann,T.,
            Geyer,M., Bonaguro,L., Barry,S.C., Schultze,J.L. and Beyer,M.D.
  TITLE     Satb1 directs the differentiation of TH17 cells through suppression
            of IL-2 expression
  JOURNAL   Cell Rep 44 (7), 115866 (2025)
   PUBMED   40531625
REFERENCE   3  (residues 1 to 429)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 429)
  AUTHORS   Huang,M., Wang,D., Huang,J., Bae,A.N., Xia,Y., Zhao,X., Mortaja,M.,
            Azin,M., Collier,M.R., Semenov,Y.R., Park,J.H. and Demehri,S.
  TITLE     Hepatitis B virus promotes liver cancer by modulating the immune
            response to environmental carcinogens
  JOURNAL   Nat Commun 16 (1), 5360 (2025)
   PUBMED   40579434
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 429)
  AUTHORS   Manrique-Rincon,A.J., Foster,B., Horswell,S., Goulding,D.A.,
            Adams,D.J. and Speak,A.O.
  TITLE     Simulating CD8 T cell exhaustion: A comprehensive approach
  JOURNAL   iScience 28 (7), 112897 (2025)
   PUBMED   40678524
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 429)
  AUTHORS   Blair,P.J., Bultman,S.J., Haas,J.C., Rouse,B.T., Wilkinson,J.E. and
            Godfrey,V.L.
  TITLE     CD4+CD8- T cells are the effector cells in disease pathogenesis in
            the scurfy (sf) mouse
  JOURNAL   J Immunol 153 (8), 3764-3774 (1994)
   PUBMED   7930593
REFERENCE   7  (residues 1 to 429)
  AUTHORS   Blair,P.J., Carpenter,D.A., Godfrey,V.L., Russell,L.B.,
            Wilkinson,J.E. and Rinchik,E.M.
  TITLE     The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3
            on the proximal X chromosome
  JOURNAL   Mamm Genome 5 (10), 652-654 (1994)
   PUBMED   7849405
REFERENCE   8  (residues 1 to 429)
  AUTHORS   Godfrey,V.L., Rouse,B.T. and Wilkinson,J.E.
  TITLE     Transplantation of T cell-mediated, lymphoreticular disease from
            the scurfy (sf) mouse
  JOURNAL   Am J Pathol 145 (2), 281-286 (1994)
   PUBMED   8053488
REFERENCE   9  (residues 1 to 429)
  AUTHORS   Godfrey,V.L., Wilkinson,J.E. and Russell,L.B.
  TITLE     X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
  JOURNAL   Am J Pathol 138 (6), 1379-1387 (1991)
   PUBMED   2053595
REFERENCE   10 (residues 1 to 429)
  AUTHORS   Lyon,M.F., Peters,J., Glenister,P.H., Ball,S. and Wright,E.
  TITLE     The scurfy mouse mutant has previously unrecognized hematological
            abnormalities and resembles Wiskott-Aldrich syndrome
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2433-2437 (1990)
   PUBMED   2320565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731793.18 and AL672231.7.
            
            Summary: The protein encoded by this gene is a member of the
            forkhead/winged-helix family of transcriptional regulators. Defects
            in this gene result in the scurfy phenotype (sf). Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ387959.1, AK157447.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.41 cM"
     Protein         1..429
                     /product="forkhead box protein P3"
                     /note="scurfy"
                     /calculated_mol_wt=47216
     mat_peptide     1..417
                     /product="Forkhead box protein P3, C-terminally processed.
                     /evidence=ECO:0000305|PubMed:19117830. /id=PRO_0000432436"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
                     /calculated_mol_wt=46034
     Region          1..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000269|PubMed:23853094; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            31
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            51..52
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:19117830;
                     propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     mat_peptide     52..417
                     /product="Forkhead box protein P3 41 kDa form.
                     /evidence=ECO:0000305|PubMed:19117830. /id=PRO_0000432437"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
                     /calculated_mol_wt=40815
     Region          67..75
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          91..95
                     /region_name="LXXLL motif.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          105..189
                     /region_name="Essential for transcriptional repressor
                     activity and for interaction with KAT5 and HDAC7.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          148..198
                     /region_name="Interaction with IKZF4.
                     /evidence=ECO:0000269|PubMed:19696312"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK2.
                     /evidence=ECO:0000269|PubMed:23853094; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          192..259
                     /region_name="FOXP-CC"
                     /note="FOXP coiled-coil domain; pfam16159"
                     /db_xref="CDD:465036"
     Region          238..259
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          238..247
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            262
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            267
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:22312127; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          277..336
                     /region_name="Interaction with RUNX1.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Region          337..417
                     /region_name="FH_FOXP3"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     P3 (FOXP3) and similar proteins; cd20066"
                     /db_xref="CDD:410840"
     Site            order(337..338,340,342..343,345..348,350..352,357..360,
                     363..374,377..378,381..382,384..386,388..389,395,400..402,
                     405..408,410,413,415..417)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:410840"
     Site            order(341..342,360..361,364,378,380,383,386..387,390,397,
                     404,406)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410840"
     Region          414..417
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            417..418
                     /site_type="cleavage"
                     /note="Cleavage, by PCSK1 or PCSK2.
                     /evidence=ECO:0000269|PubMed:19117830; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BZS1; propagated from
                     UniProtKB/Swiss-Prot (Q99JB6.1)"
     CDS             1..429
                     /gene="Foxp3"
                     /gene_synonym="JM2; scurfin; sf"
                     /coded_by="NM_001199347.2:346..1635"
                     /db_xref="CCDS:CCDS29965.1"
                     /db_xref="GeneID:20371"
                     /db_xref="MGI:MGI:1891436"
ORIGIN      
        1 mpnprpakpm apslalgpsp gvlpswktap kgsellgtrg sggpfqgrdl rsgahtsssl
       61 nplppsqlql ptvplvmvap sgarlgpsph lqallqdrph fmhqlstvda haqtpvlqvr
      121 pldnpamisl pppsaatgvf slkarpglpp ginvaslewv srepallctf prsgtprkds
      181 nllaapqgsy pllangvckw pgcekvfeep eeflkhcqad hlldekgkaq cllqrevvqs
      241 leqqleleke klgamqahla gkmalakaps vasmdksscc ivatstqgsv lpawsaprea
      301 pdgglfavrr hlwgshgnss fpeffhnmdy fkyhnmrppf tyatlirwai leaperqrtl
      361 neiyhwftrm fayfrnhpat wknairhnls lhkcfvrves ekgavwtvde fefrkkrsqr
      421 pnkcsnpcp
//
LOCUS       NP_067434                349 aa            linear   ROD 27-AUG-2025
DEFINITION  insulin gene enhancer protein ISL-1 [Mus musculus].
ACCESSION   NP_067434 XP_354773
VERSION     NP_067434.3
DBSOURCE    REFSEQ: accession NM_021459.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Nickerson,K.R., Sammoura,F.M., Zhou,Y. and Jaworski,A.
  TITLE     Slit-Robo signaling supports motor neuron avoidance of the spinal
            cord midline through DCC antagonism and other mechanisms
  JOURNAL   Front Cell Dev Biol 13, 1563403 (2025)
   PUBMED   40276653
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 349)
  AUTHORS   Catela,C., Assimacopoulos,S., Chen,Y., Tsioras,K., Feng,W. and
            Kratsios,P.
  TITLE     The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets
            involved in motor neuron development
  JOURNAL   iScience 28 (4), 112210 (2025)
   PUBMED   40230530
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 349)
  AUTHORS   Gunther,T., Struwe,M., Aguzzi,A. and Schughart,K.
  TITLE     Open brain, a new mouse mutant with severe neural tube defects,
            shows altered gene expression patterns in the developing spinal
            cord
  JOURNAL   Development 120 (11), 3119-3130 (1994)
   PUBMED   7720556
REFERENCE   7  (residues 1 to 349)
  AUTHORS   Weinstein,D.C., Ruiz i Altaba,A., Chen,W.S., Hoodless,P.,
            Prezioso,V.R., Jessell,T.M. and Darnell,J.E. Jr.
  TITLE     The winged-helix transcription factor HNF-3 beta is required for
            notochord development in the mouse embryo
  JOURNAL   Cell 78 (4), 575-588 (1994)
   PUBMED   8069910
REFERENCE   8  (residues 1 to 349)
  AUTHORS   Dickinson,M.E., Krumlauf,R. and McMahon,A.P.
  TITLE     Evidence for a mitogenic effect of Wnt-1 in the developing
            mammalian central nervous system
  JOURNAL   Development 120 (6), 1453-1471 (1994)
   PUBMED   8050356
REFERENCE   9  (residues 1 to 349)
  AUTHORS   Thor,S., Ericson,J., Brannstrom,T. and Edlund,T.
  TITLE     The homeodomain LIM protein Isl-1 is expressed in subsets of
            neurons and endocrine cells in the adult rat
  JOURNAL   Neuron 7 (6), 881-889 (1991)
   PUBMED   1764243
REFERENCE   10 (residues 1 to 349)
  AUTHORS   Karlsson,O., Thor,S., Norberg,T., Ohlsson,H. and Edlund,T.
  TITLE     Insulin gene enhancer binding protein Isl-1 is a member of a novel
            class of proteins containing both a homeo- and a Cys-His domain
  JOURNAL   Nature 344 (6269), 879-882 (1990)
   PUBMED   1691825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170086.2, AK090263.1 and CF725499.1.
            
            On Dec 11, 2007 this sequence version replaced NP_067434.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090263.1, BC132263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.87 cM"
     Protein         1..349
                     /product="insulin gene enhancer protein ISL-1"
                     /note="Lim-homeodomain protein Islet1; islet-1; insulin
                     related protein; Islet 1"
                     /calculated_mol_wt=38905
     Region          17..71
                     /region_name="LIM1_Isl"
                     /note="The first LIM domain of Isl, a member of LHX
                     protein family; cd09366"
                     /db_xref="CDD:188752"
     Site            order(17,20,39,42,45,48,67,70)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188752"
     Region          79..133
                     /region_name="LIM2_Isl"
                     /note="The second LIM domain of Isl, a member of LHX
                     protein family; cd09374"
                     /db_xref="CDD:188760"
     Site            order(79,82,101,104,107,110,129,132)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188760"
     Region          181..237
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(183..186,188,205,211,224,226..227,230..231,233..235,
                     237..238)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(184,187,227,230..231,234)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          262..291
                     /region_name="LIM-binding domain (LID)"
                     /note="propagated from UniProtKB/Swiss-Prot (P61372.1)"
     Region          312..349
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P61372.1)"
     CDS             1..349
                     /gene="Isl1"
                     /coded_by="NM_021459.4:267..1316"
                     /db_xref="CCDS:CCDS26790.1"
                     /db_xref="GeneID:16392"
                     /db_xref="MGI:MGI:101791"
ORIGIN      
        1 mgdmgdppkk krlislcvgc gnqihdqyil rvspdlewha aclkcaecnq yldesctcfv
       61 rdgktyckrd yirlygikca kcsigfsknd fvmrarskvy hiecfrcvac srqlipgdef
      121 alredglfcr adhdvveras lgagdplspl hparplqmaa episarqpal rphvhkqpek
      181 ttrvrtvlne kqlhtlrtcy aanprpdalm keqlvemtgl sprvirvwfq nkrckdkkrs
      241 immkqlqqqq pndktniqgm tgtpmvaasp erhdgglqan pvevqsyqpp wkvlsdfalq
      301 sdidqpafqq lvnfseggpg snstgsevas mssqlpdtpn smvaspiea
//
LOCUS       NP_001155195             475 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor EB [Mus musculus].
ACCESSION   NP_001155195
VERSION     NP_001155195.1
DBSOURCE    REFSEQ: accession NM_001161723.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Custode,B.M., Annunziata,F., Dos Santos Matos,F., Schiano,V.,
            Maffia,V., Lillo,M., Colonna,R., De Cegli,R., Ballabio,A. and
            Pastore,N.
  TITLE     Folliculin depletion results in liver cell damage and
            cholangiocarcinoma through MiT/TFE activation
  JOURNAL   Cell Death Differ 32 (8), 1460-1472 (2025)
   PUBMED   40189703
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Kumar,G.V.N., Wang,R.S., Sharma,A.X., David,N.L., Amorim,T.,
            Sinden,D.S., Doshi,N.K., Wabitsch,M., Gingras,S., Ejaz,A.,
            Rubin,J.P., Maron,B.A., Fazeli,P.K. and Steinhauser,M.L.
  TITLE     Non-canonical lysosomal lipolysis drives mobilization of adipose
            tissue energy stores with fasting
  JOURNAL   Nat Commun 16 (1), 1330 (2025)
   PUBMED   39900947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Lei,Q., Chen,X., Xiong,Y., Li,S., Wang,J., He,H. and Deng,Y.
  TITLE     Lysosomal Ca2+ release-facilitated TFEB nuclear translocation
            alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons
  JOURNAL   Sci Rep 14 (1), 24836 (2024)
   PUBMED   39438678
  REMARK    GeneRIF: Lysosomal Ca[2+] release-facilitated TFEB nuclear
            translocation alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124830.8 and AC113536.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154971.1, SRR17253014.4925554.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..475
                     /product="transcription factor EB"
                     /calculated_mol_wt=52483
     Region          1..166
                     /region_name="Interaction with ACSS2.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          4..161
                     /region_name="MITF_TFEB_C_3_N"
                     /note="MITF/TFEB/TFEC/TFE3 N-terminus; pfam15951"
                     /db_xref="CDD:464952"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          135..152
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          155..164
                     /region_name="Strong transcription activation domain.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          225..315
                     /region_name="bHLHzip_TFEB"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in transcription factor EB (TFEB) and similar
                     proteins; cd18927"
                     /db_xref="CDD:381497"
     Site            order(239..240,242..243,246..247,251,272..273)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381497"
     Region          244..247
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            order(249..250,253..254,256,260,273,277..278,281,283..285,
                     287..288,290..291,294,297..299)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381497"
     Region          297..318
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          320..472
                     /region_name="DUF3371"
                     /note="Domain of unknown function (DUF3371); pfam11851"
                     /db_xref="CDD:463372"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          351..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          445..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     CDS             1..475
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /coded_by="NM_001161723.2:64..1491"
                     /db_xref="CCDS:CCDS50133.1"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
ORIGIN      
        1 masriglrmq lmreqaqqee qrermqqqav mhymqqqqqq qqqlggpptp aintpvhfqs
       61 pppvpgevlk vqsylenpts yhlqqsqhqk vreylsetyg nkfaahvspa qgspkpapaa
      121 spgvraghvl stsagnsapn spmamlhiss npekefddvi dnimrldsvl gyinpemqmp
      181 ntlplssshl nvysgdpqvt asmvgvtsss cpadltqkre ltdaesrala kerqkkdnhn
      241 lierrrrfni ndrikelgml ipkandldvr wnkgtilkas vdyirrmqkd lqksrelenh
      301 srrlemtnkq lwlriqelem qarvhglptt spsgvnmael aqqvvkqelp sedgpgealm
      361 lgpevpepeq mpalppqapl psaaqpqspf hhldfshgls fggggdegpt gypdtlgteh
      421 gspfpnlskk dldlmlldds llplasdplf stmspeaska ssrrssfsme egdvl
//
LOCUS       NP_001390171             188 aa            linear   ROD 27-AUG-2025
DEFINITION  GTPase KRas isoform 1 [Mus musculus].
ACCESSION   NP_001390171
VERSION     NP_001390171.1
DBSOURCE    REFSEQ: accession NM_001403242.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 188)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 188)
  AUTHORS   Quijano,E., Martinez-Saucedo,D., Ianniello,Z., Pinto-Medici,N.,
            Rackear,M., Chen,H., Lola-Pereira,L., Liu,Y., Hegan,D., Shan,X.,
            Tseng,R., Yugawa,D., Chowdhury,S., Khang,M., Singh,J.P.,
            Abdullah,R., Azhir,P., Kashima,S., Woods,W.S., Gosstola,N.,
            Turner,B.C., Squinto,S., Ludwig,D.L., Bindra,R.S., Robert,M.E.,
            Braun,D.A., Perez Pinera,P., Saltzman,W.M., Escobar-Hoyos,L.F. and
            Glazer,P.M.
  TITLE     Systemic administration of an RNA binding and cell-penetrating
            antibody targets therapeutic RNA to multiple mouse models of cancer
  JOURNAL   Sci Transl Med 17 (807), eadk1868 (2025)
   PUBMED   40668891
REFERENCE   3  (residues 1 to 188)
  AUTHORS   Suzuki,Y., Sugimori,M., Kanemaru,Y., Onodera,S., Tsuchiya,H.,
            Ikeda,A., Ikeda,R., Goda,Y., Kaneko,H., Irie,K., Sue,S., Ijichi,H.
            and Maeda,S.
  TITLE     Development of a novel PIK3CA-mutated pancreatic tumor mouse model
            and evaluation of the therapeutic effects of a PI3K inhibitor
  JOURNAL   PLoS One 20 (7), e0326491 (2025)
   PUBMED   40638603
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 188)
  AUTHORS   Poirier,A., Tribouillard,L., Kordahi,M., Gelinas,Y., Roy,J.,
            Beaulieu,M.J., Orain,M., Blanchet,M.R., Joubert,P. and Laplante,M.
  TITLE     Generation and characterization of a Cre-inducible ZNF768
            overexpression mouse model
  JOURNAL   Sci Rep 15 (1), 19792 (2025)
   PUBMED   40473701
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 188)
  AUTHORS   Woo,S.M., Lee,H., Kang,J.H., Kang,M., Choi,W., Sim,S.H., Chun,J.W.,
            Han,N., Kim,K.H., Ham,W., Hong,W., Kim,C., Park,J.H., Han,D.,
            Yook,J.I., Lee,W.J. and Kim,S.Y.
  TITLE     Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the
            Tumor-Promoting Effects of a High-Fat Diet
  JOURNAL   Theranostics 15 (13), 6516-6533 (2025)
   PUBMED   40521210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 188)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (residues 1 to 188)
  AUTHORS   Lord,P.G., Hardaker,K.J., Loughlin,J.M., Marsden,A.M. and
            Orton,T.C.
  TITLE     Point mutation analysis of ras genes in spontaneous and chemically
            induced C57Bl/10J mouse liver tumours
  JOURNAL   Carcinogenesis 13 (8), 1383-1387 (1992)
   PUBMED   1499088
REFERENCE   8  (residues 1 to 188)
  AUTHORS   You,M., Wang,Y., Stoner,G., You,L., Maronpot,R., Reynolds,S.H. and
            Anderson,M.
  TITLE     Parental bias of Ki-ras oncogenes detected in lung tumors from
            mouse hybrids
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5804-5808 (1992)
   PUBMED   1352876
REFERENCE   9  (residues 1 to 188)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (residues 1 to 188)
  AUTHORS   Scolnick,E.M., Papageorge,A.G. and Shih,T.Y.
  TITLE     Guanine nucleotide-binding activity as an assay for src protein of
            rat-derived murine sarcoma viruses
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5355-5359 (1979)
   PUBMED   228288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157091.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.8897966.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN01164131 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     Protein         1..188
                     /product="GTPase KRas isoform 1"
                     /EC_number="3.6.5.2"
                     /note="Kirsten rat sarcoma oncogene 2, expressed; p21
                     protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene
                     homolog; GTPase KRas"
                     /calculated_mol_wt=21351
     Region          3..164
                     /region_name="H_N_K_Ras_like"
                     /note="Ras GTPase family containing H-Ras,N-Ras and
                     K-Ras4A/4B; cd04138"
                     /db_xref="CDD:133338"
     Site            10..17
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133338"
     Site            order(11..12,59..60)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133338"
     Site            order(12..18,28..30,32,35,60,116..117,119..120,145..146)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:133338"
     Site            order(17..18,30..32,34,37,40..41,54..55,57,59..61,63..65,
                     67,69..71,73,102..103,147)
                     /site_type="other"
                     /note="GEF interaction site [polypeptide binding]"
                     /db_xref="CDD:133338"
     Site            order(25,37..41)
                     /site_type="active"
                     /note="effector interaction site [active]"
                     /db_xref="CDD:133338"
     Site            33..40
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:133338"
     Site            35
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133338"
     Site            57..60
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:133338"
     Site            59..77
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:133338"
     Site            116..119
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133338"
     Site            145..147
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133338"
     CDS             1..188
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /coded_by="NM_001403242.1:345..911"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
ORIGIN      
        1 mteyklvvvg aggvgksalt iqliqnhfvd eydptiedsy rkqvvidget clldildtag
       61 qeeysamrdq ymrtgegflc vfainntksf edihhyreqi krvkdsedvp mvlvgnkcdl
      121 psrtvdtkqa qelarsygip fietsaktrq gvddafytlv reirkhkekm skdgkkkkkk
      181 srtrctvm
//
LOCUS       NP_001342569             415 aa            linear   ROD 27-AUG-2025
DEFINITION  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2
            [Mus musculus].
ACCESSION   NP_001342569 XP_006520016
VERSION     NP_001342569.1
DBSOURCE    REFSEQ: accession NM_001355640.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Cobo,I., Murillo-Saich,J., Alishala,M., Calderon,S., Coras,R.,
            Hemming,B., Inkum,F., Rosas,F., Takei,R., Spann,N., Prohaska,T.A.,
            Alabarse,P.V.G., Jeong,S.J., Nickl,C.K., Cheng,A., Li,B., Vogel,A.,
            Weichhart,T., Fuster,J.J., Le,T., Bradstreet,T.R., Webber,A.M.,
            Edelson,B.T., Razani,B., Ebert,B.L., Taneja,R., Terkeltaub,R.,
            Bryan,R.L., Guma,M. and Glass,C.K.
  TITLE     Particle uptake by macrophages triggers bifurcated transcriptional
            pathways that differentially regulate inflammation and lysosomal
            gene expression
  JOURNAL   Immunity 58 (4), 826-842 (2025)
   PUBMED   40118070
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Peng,C., Jiang,H., Jing,L., Yang,W., Guan,X., Wang,H., Yu,S.,
            Cao,Y., Wang,M., Ma,H., Lv,Z., Gu,H., Xia,C., Guo,X., Sun,B.,
            Wang,A., Xie,C., Wu,W., Lu,L., Song,J., Lei,S., Wu,R., Zang,Y.,
            Tang,E. and Li,J.
  TITLE     Macrophage SUCLA2 coupled glutaminolysis manipulates obesity
            through AMPK
  JOURNAL   Nat Commun 16 (1), 1738 (2025)
   PUBMED   39966410
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 415)
  AUTHORS   Xie,F., Zhou,X., Ran,Y., Li,R., Zou,J., Wan,S., Su,P., Meng,X.,
            Yan,H., Lu,H., Ru,H., Hu,H., Mao,Z., Yang,B., Zhou,F. and Zhang,L.
  TITLE     Targeting FOXM1 condensates reduces breast tumour growth and
            metastasis
  JOURNAL   Nature 638 (8052), 1112-1121 (2025)
   PUBMED   39814884
REFERENCE   6  (residues 1 to 415)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 415)
  AUTHORS   Sato,T., Sato-Harada,R., Takano,M., Kato,S., Saburi,S. and
            Harada,A.
  TITLE     Localization of cAMP-dependent protein kinase in the actin and
            microtubule cytoskeletons in mouse hippocampal neurons
  JOURNAL   Neurosci Lett 325 (2), 83-86 (2002)
   PUBMED   12044627
REFERENCE   8  (residues 1 to 415)
  AUTHORS   Fryer,L.G., Foufelle,F., Barnes,K., Baldwin,S.A., Woods,A. and
            Carling,D.
  TITLE     Characterization of the role of the AMP-activated protein kinase in
            the stimulation of glucose transport in skeletal muscle cells
  JOURNAL   Biochem J 363 (Pt 1), 167-174 (2002)
   PUBMED   11903059
REFERENCE   9  (residues 1 to 415)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 415)
  AUTHORS   Turnley,A.M., Stapleton,D., Mann,R.J., Witters,L.A., Kemp,B.E. and
            Bartlett,P.F.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135079.9.
            
            On Sep 22, 2017 this sequence version replaced XP_006520016.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.149686.1,
                                           ERR3363658.2031903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.99 cM"
     Protein         1..415
                     /product="5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 isoform 2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /EC_number="2.7.11.31"
                     /note="5'-AMP-activated protein kinase catalytic subunit
                     alpha-1; AMP-activated protein kinase, alpha 1 catalytic
                     subunit; AMPK subunit alpha-1; ACACA kinase; HMGCR kinase;
                     acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA
                     reductase kinase; tau-protein kinase PRKAA1"
                     /calculated_mol_wt=47089
     Region          <1..135
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          152..216
                     /region_name="UBA_AID_AAPK1"
                     /note="UBA-like autoinhibitory domain (AID) found in
                     vertebrate 5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 (AMPKalpha-1); cd14403"
                     /db_xref="CDD:270586"
     Region          260..413
                     /region_name="AMPKA1_C"
                     /note="C-terminal regulatory domain of 5'-AMP-activated
                     protein kinase (AMPK) alpha 1 catalytic subunit; cd12199"
                     /db_xref="CDD:213384"
     Site            order(260..266,268,273,295..297,317..321,326,329..332,334,
                     399,402..404,406..407,411)
                     /site_type="other"
                     /note="beta subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     Site            order(260,305,307,397..398,400..401,404)
                     /site_type="other"
                     /note="gamma subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     CDS             1..415
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /coded_by="NM_001355640.1:347..1594"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:105787"
                     /db_xref="MGI:MGI:2145955"
ORIGIN      
        1 mvvhrdlkpe nvlldahmna kiadfglsnm msdgeflrts cgspnyaape visgrlyagp
       61 evdiwssgvi lyallcgtlp fdddhvptlf kkicdgifyt pqylnpsvis llkhmlqvdp
      121 mkraaikdir ehewfkqdlp kylfpedpsy sstmiddeal kevcekfecs eeevlsclyn
      181 rnhqdplava yhliidnrri mneakdfyla tsppdsfldd hhltrphper vpflvaetpr
      241 arhtldelnp qkskhqgvrk akwhlgirsq srpndimaev craikqldye wkvvnpyylr
      301 vrrknpvtst fskmslqlyq vdsrtylldf rsiddeitea ksgtatpqrs gsisnyrscq
      361 rsdsdaeaqg kpsdvsltss vtsldsspvd vaprpgshti effemcanli kilaq
//
LOCUS       NP_001407424             437 aa            linear   ROD 27-AUG-2025
DEFINITION  retinoic acid receptor RXR-gamma isoform 3 [Mus musculus].
ACCESSION   NP_001407424 XP_030108186
VERSION     NP_001407424.1
DBSOURCE    REFSEQ: accession NM_001420495.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Zang,Y., Liu,S., Rao,Z., Wang,Y., Zhang,B., Li,H., Cao,Y., Zhou,J.,
            Shen,Z., Duan,S., He,D. and Xu,H.
  TITLE     Retinoid X receptor gamma dictates the activation threshold of
            group 2 innate lymphoid cells and limits type 2 inflammation in the
            small intestine
  JOURNAL   Immunity 56 (11), 2542-2554 (2023)
   PUBMED   37714152
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Leung,A.M., Rao,M.B., Raju,N., Chung,M., Klinger,A., Rowe,D.J.,
            Li,X. and Levine,E.M.
  TITLE     A framework to identify functional interactors that contribute to
            disrupted early retinal development in Vsx2 ocular retardation J
            mice
  JOURNAL   Dev Dyn 252 (11), 1338-1362 (2023)
   PUBMED   37259952
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w. PMID: 37322272]
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Bach,I., Rhodes,S.J., Pearse,R.V. 2nd, Heinzel,T., Gloss,B.,
            Scully,K.M., Sawchenko,P.E. and Rosenfeld,M.G.
  TITLE     P-Lim, a LIM homeodomain factor, is expressed during pituitary
            organ and cell commitment and synergizes with Pit-1
  JOURNAL   Proc Natl Acad Sci U S A 92 (7), 2720-2724 (1995)
   PUBMED   7708713
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Mangelsdorf,D.J., Borgmeyer,U., Heyman,R.A., Zhou,J.Y., Ong,E.S.,
            Oro,A.E., Kakizuka,A. and Evans,R.M.
  TITLE     Characterization of three RXR genes that mediate the action of
            9-cis retinoic acid
  JOURNAL   Genes Dev 6 (3), 329-344 (1992)
   PUBMED   1312497
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Leid,M., Kastner,P., Lyons,R., Nakshatri,H., Saunders,M.,
            Zacharewski,T., Chen,J.Y., Staub,A., Garnier,J.M., Mader,S. et al.
  TITLE     Purification, cloning, and RXR identity of the HeLa cell factor
            with which RAR or TR heterodimerizes to bind target sequences
            efficiently
  JOURNAL   Cell 68 (2), 377-395 (1992)
   PUBMED   1310259
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887. PMID: 1330328]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093318.52 and AC093452.50.
            
            On May 2, 2023 this sequence version replaced XP_030108186.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.47186.1,
                                           SRR7345562.1671899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.99 cM"
     Protein         1..437
                     /product="retinoic acid receptor RXR-gamma isoform 3"
                     /note="retinoic acid receptor RXR-gamma; nuclear receptor
                     subfamily 2 group B member 3"
                     /calculated_mol_wt=48027
     Region          1..108
                     /region_name="Nuc_recep-AF1"
                     /note="Nuclear/hormone receptor activator site AF-1;
                     pfam11825"
                     /db_xref="CDD:463363"
     Region          111..187
                     /region_name="NR_DBD_RXR"
                     /note="DNA-binding domain of retinoid X receptor (RXR) is
                     composed of two C4-type zinc fingers; cd06956"
                     /db_xref="CDD:143514"
     Site            order(113,116,130,133,149,155,165,168)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143514"
     Site            order(118,159..160,162,164)
                     /site_type="other"
                     /note="RXR/ECR heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:143514"
     Site            order(122..125,131..132,134,136,138..139,142,150,162..163,
                     166,169,182..184,186..187)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143514"
     Site            order(144,167,170..171,174..175,179..181,185..187)
                     /site_type="other"
                     /note="RXR/PPAR heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:143514"
     Site            order(160..161,164)
                     /site_type="other"
                     /note="RXR/RXR homodimer interface DR1 [polypeptide
                     binding]"
                     /db_xref="CDD:143514"
     Site            181..186
                     /site_type="other"
                     /note="RXR/RXR homodimer interface DR2 [polypeptide
                     binding]"
                     /db_xref="CDD:143514"
     Site            order(185,187)
                     /site_type="other"
                     /note="RXR/RAR heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:143514"
     Region          207..415
                     /region_name="NR_LBD_RXR_like"
                     /note="The ligand binding domain of the retinoid X
                     receptor and Ultraspiracle, members of nuclear receptor
                     superfamily; cd06943"
                     /db_xref="CDD:132741"
     Site            order(243..244,246..247,250,284,288,291,301..302,317,407,
                     410..411)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132741"
     Site            order(252,255,259,264,269..270,272..273,277)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132741"
     Site            order(323,327,331,348,354,368..369,372..373,376,390..391,
                     394..395,397..399,401..402,405,409)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:132741"
     Site            order(323,327,331,354,356,365,372,376,388,391..392,
                     395..398,401..402,405,409)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:132741"
     CDS             1..437
                     /gene="Rxrg"
                     /gene_synonym="Nr2b3"
                     /coded_by="NM_001420495.1:640..1953"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:20183"
                     /db_xref="MGI:MGI:98216"
ORIGIN      
        1 mspsvalptg kpmdshpsyt dtpvsaprtl savgtplnal gspyrvitsa mgppsgalaa
       61 ppginlvapp ssqlnvvnsv sssedikplp glpgignmny pstspgslvk hicaicgdrs
      121 sgkhygvysc egckgffkrt irkdliytcr dnkdclidkr qrnrcqycry qkclvmgmkr
      181 eavqeerqrs reraeseaec assshedmpv erileaelav epktesygdm nvenstndpv
      241 tnichaadkq lftlvewakr iphfsdltle dqvillragw nelliasfsh rsvsvqdgil
      301 latglhvhrs sahsagvgsi fdrvltelvs kmkdmqmdks elgclraivl fnpdakglsn
      361 psevetlrek vyatleaytk qkypeqpgrf aklllrlpal rsiglkcleh lfffkligdt
      421 pidsflmeml etplqit
//
LOCUS       NP_033785                583 aa            linear   ROD 27-AUG-2025
DEFINITION  CD166 antigen isoform 1 precursor [Mus musculus].
ACCESSION   NP_033785
VERSION     NP_033785.1
DBSOURCE    REFSEQ: accession NM_009655.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 583)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 583)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 583)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 583)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   5  (residues 1 to 583)
  AUTHORS   Baek,S.M., Kim,M.N., Kim,E.G., Lee,Y.J., Park,C.H., Kim,M.J.,
            Kim,K.W. and Sohn,M.H.
  TITLE     Activated Leukocyte Cell Adhesion Molecule Regulates the Expression
            of Interleukin-33 in RSV Induced Airway Inflammation by Regulating
            MAPK Signaling Pathways
  JOURNAL   Lung 202 (2), 127-137 (2024)
   PUBMED   38502305
  REMARK    GeneRIF: Activated Leukocyte Cell Adhesion Molecule Regulates the
            Expression of Interleukin-33 in RSV Induced Airway Inflammation by
            Regulating MAPK Signaling Pathways.
REFERENCE   6  (residues 1 to 583)
  AUTHORS   Fraboulet,S., Schmidt-Petri,T., Dhouailly,D. and Pourquie,O.
  TITLE     Expression of DM-GRASP/BEN in the developing mouse spinal cord and
            various epithelia
  JOURNAL   Mech Dev 95 (1-2), 221-224 (2000)
   PUBMED   10906467
REFERENCE   7  (residues 1 to 583)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   8  (residues 1 to 583)
  AUTHORS   Sekine-Aizawa,Y., Omori,A. and Fujita,S.C.
  TITLE     MuSC, a novel member of the immunoglobulin superfamily, is
            expressed in neurons of a subset of cranial sensory ganglia in the
            mouse embryo
  JOURNAL   Eur J Neurosci 10 (9), 2810-2824 (1998)
   PUBMED   9758151
REFERENCE   9  (residues 1 to 583)
  AUTHORS   Bowen,M.A., Bajorath,J., D'Egidio,M., Whitney,G.S., Palmer,D.,
            Kobarg,J., Starling,G.C., Siadak,A.W. and Aruffo,A.
  TITLE     Characterization of mouse ALCAM (CD166): the CD6-binding domain is
            conserved in different homologs and mediates cross-species binding
  JOURNAL   Eur J Immunol 27 (6), 1469-1478 (1997)
   PUBMED   9209500
REFERENCE   10 (residues 1 to 583)
  AUTHORS   Kanki,J.P., Chang,S. and Kuwada,J.Y.
  TITLE     The molecular cloning and characterization of potential chick
            DM-GRASP homologs in zebrafish and mouse
  JOURNAL   J Neurobiol 25 (7), 831-845 (1994)
   PUBMED   8089660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154383.2, AK031391.1, AK161090.1 and BE654940.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030851.1, AK031391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 32.88 cM"
     Protein         1..583
                     /product="CD166 antigen isoform 1 precursor"
                     /note="CD166 antigen"
                     /calculated_mol_wt=62321
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     mat_peptide     28..583
                     /product="CD166 antigen. /id=PRO_0000014660"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61490.3)"
                     /calculated_mol_wt=62321
     Region          29..117
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          39..43
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409329"
     Region          55..59
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409329"
     Site            95
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Region          96..100
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409329"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409329"
     Region          137..231
                     /region_name="C2-set_2"
                     /note="CD80-like C2-set immunoglobulin domain; pfam08205"
                     /db_xref="CDD:400489"
     Region          151..157
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          167..171
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Region          203..207
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          217..222
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          255..329
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Site            265
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          296..300
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Site            306
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Region          310..315
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          339..393
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Site            361
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Region          415..489
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            457
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Site            480
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Site            499
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q61490.3)"
     Site            528..549
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61490.3)"
     Region          562..583
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61490.3)"
     CDS             1..583
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /coded_by="NM_009655.3:617..2368"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS37356.1"
                     /db_xref="GeneID:11658"
                     /db_xref="MGI:MGI:1313266"
ORIGIN      
        1 maskvspscr lvfcllisaa vlrpglgwyt vnsaygdtiv mpcrldvpqn lmfgkwkyek
       61 pdgspvfiaf rsstkksvqy ddvpeykdrl slsenytlsi anakisdekr fvcmlvtedn
      121 vfeaptlvkv fkqpskpeiv nkapfletdq lkklgdcisr dsypdgnitw yrngkvlqpv
      181 egevailfkk eidpgtqlyt vtssleyktt rsdiqmpftc svtyygpsgq ktiyseqeif
      241 diyypteqvt iqvlppknai kegdnitlqc lgngnpppee fmfylpgqpe girssntytl
      301 tdvrrnatgd ykcslidkrn maasttitvh yldlslnpsg evtkqigdtl pvsctisasr
      361 natvvwmkdn irlrsspsfs slhyqdagny vcetalqeve glkkresltl ivegkpqikm
      421 tkktdpsgls ktiichvegf pkpaihwtit gsgsvinqte espyingryy skiiispeen
      481 vtltctaenq lertvnslnv saisipehde addisdenre kvndqakliv givvglllaa
      541 lvagvvywly mkksktaskh vnkdlgnmee nkkleennhk tea
//
LOCUS       NP_001390938             835 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4-like isoform 4 [Mus musculus].
ACCESSION   NP_001390938 XP_030106504
VERSION     NP_001390938.1
DBSOURCE    REFSEQ: accession NM_001404009.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 835)
  AUTHORS   Zeng,Q., Guo,H., Tang,N., Renavikar,P.S., Karandikar,N.J.,
            Lovett-Racke,A.E., Racke,M.K., Yan,C., Tang,R., Sinha,S., Ghosh,K.,
            Ryal,J.P., Ouyang,S., Chen,M., Amari,F., Vincenzo,C., Pope,R.M.,
            Li,Y., Yang,H., Langdon,W.Y. and Zhang,J.
  TITLE     K27-linked RORgammat ubiquitination by Nedd4 potentiates
            Th17-mediated autoimmunity
  JOURNAL   J Biomed Sci 32 (1), 26 (2025)
   PUBMED   39972304
  REMARK    Erratum:[J Biomed Sci. 2025 Apr 16;32(1):42. doi:
            10.1186/s12929-025-01136-8. PMID: 40234865]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 835)
  AUTHORS   Liu,H., Wang,N., Yang,R., Luan,J., Cao,M., Zhai,C., Wang,S.,
            Wei,M., Wang,D., Qiao,J., Liu,Y., She,W., Guo,N., Liao,B. and
            Gou,X.
  TITLE     E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis
            by Inhibiting IL-6/GP130 Signaling Pathway
  JOURNAL   J Invest Dermatol 144 (11), 2453-2464 (2024)
   PUBMED   38580105
  REMARK    GeneRIF: E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin
            Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
REFERENCE   3  (residues 1 to 835)
  AUTHORS   Blackburn,D.M., Sahinyan,K., Hernandez-Corchado,A., Lazure,F.,
            Richard,V., Raco,L., Perron,G., Zahedi,R.P., Borchers,C.H.,
            Lepper,C., Kawabe,H., Jahani-Asl,A., Najafabadi,H.S. and
            Soleimani,V.D.
  TITLE     The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell
            quiescence by inhibiting their activation
  JOURNAL   iScience 27 (7), 110241 (2024)
   PUBMED   39015146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 835)
  AUTHORS   Han,F., Wu,S., Dong,Y., Liu,Y., Sun,B. and Chen,L.
  TITLE     Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by
            downregulating CaMKKbeta in diabetic kidney disease
  JOURNAL   J Transl Med 22 (1), 465 (2024)
   PUBMED   38755664
  REMARK    GeneRIF: Aberrant expression of NEDD4L disrupts mitochondrial
            homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 835)
  AUTHORS   Flasza,M., Gorman,P., Roylance,R., Canfield,A.E. and Baron,M.
  TITLE     Alternative splicing determines the domain structure of WWP1, a
            Nedd4 family protein
  JOURNAL   Biochem Biophys Res Commun 290 (1), 431-437 (2002)
   PUBMED   11779188
REFERENCE   7  (residues 1 to 835)
  AUTHORS   Debonneville,C., Flores,S.Y., Kamynina,E., Plant,P.J., Tauxe,C.,
            Thomas,M.A., Munster,C., Chraibi,A., Pratt,J.H., Horisberger,J.D.,
            Pearce,D., Loffing,J. and Staub,O.
  TITLE     Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+)
            channel cell surface expression
  JOURNAL   EMBO J 20 (24), 7052-7059 (2001)
   PUBMED   11742982
REFERENCE   8  (residues 1 to 835)
  AUTHORS   Harvey,K.F., Dinudom,A., Cook,D.I. and Kumar,S.
  TITLE     The Nedd4-like protein KIAA0439 is a potential regulator of the
            epithelial sodium channel
  JOURNAL   J Biol Chem 276 (11), 8597-8601 (2001)
   PUBMED   11244092
REFERENCE   9  (residues 1 to 835)
  AUTHORS   Kamynina,E., Debonneville,C., Bens,M., Vandewalle,A. and Staub,O.
  TITLE     A novel mouse Nedd4 protein suppresses the activity of the
            epithelial Na+ channel
  JOURNAL   FASEB J 15 (1), 204-214 (2001)
   PUBMED   11149908
REFERENCE   10 (residues 1 to 835)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102333.10, AC161175.5 and AC102288.11.
            
            On Apr 7, 2022 this sequence version replaced XP_030106504.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.109268.1,
                                           SRR6116558.115613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 37.57 cM"
     Protein         1..835
                     /product="E3 ubiquitin-protein ligase NEDD4-like isoform
                     4"
                     /EC_number="2.3.2.26"
                     /EC_number="2.3.2.36"
                     /note="E3 ubiquitin-protein ligase NEDD4-like; neural
                     precursor cell expressed, developmentally down-regulated
                     gene 4b; HECT-type E3 ubiquitin transferase NED4L"
                     /calculated_mol_wt=96266
     Region          <1..32
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          77..103
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          247..276
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          360..390
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(374,385)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          409..441
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(425,436)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(484,515,526,588,761,796..797,800..804,824,831)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          502..831
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(616,619..620,622..623,626,631,633,637..638,640,645,
                     650,667,671)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..835
                     /gene="Nedd4l"
                     /gene_synonym="1300012C07Rik; Nedd4-2; NEDD4.2; Nedd4b"
                     /coded_by="NM_001404009.1:425..2932"
                     /note="isoform 4 is encoded by transcript variant 6"
                     /db_xref="GeneID:83814"
                     /db_xref="MGI:MGI:1933754"
ORIGIN      
        1 merpytfkdf llrprshksr vkgflrlkma ympknggqde enseqrddme hgwevvdsnd
       61 sasqhqeelp ppplppgwee kvdnlgrtyy vnhnnrstqw hrpslmdvss esdnnirqin
      121 qeaahrrfrs rrhisedlep easegggegp epwetiseem nmagdslsla lppppaspvs
      181 rtspqelsee vsrrlqitpd sngeqfssli qrepssrlrs csvtdtvaeq ahlpppsvay
      241 vhttpglpsg weerkdakgr tyyvnhnnrt ttwtrpimql aedgasgsat nsnnhlvepq
      301 irrprslssp tvtlsapleg akdspirrav kdtlsnpqsp qpspynspkp qhkvtqsflp
      361 pgwemriapn grpffidhnt ktttwedprl kfpvhmrska slnpndlgpl ppgweerihl
      421 dgrtfyidhn skitqwedpr lqnpaitgpa vpysrefkqk ydyfrkklkk padipnrfem
      481 klhrnnifee syrrimsvkr pdvlkarlwi efesekgldy ggvarewffl lskemfnpyy
      541 glfeysatdn ytlqinpnsg lcnedhlsyf tfigrvagla vfhgklldgf firpfykmml
      601 gkqitlndme svdseyynsl kwilendpte ldlmfcidee nfgqtyqvdl kpngseimvt
      661 nenkreyidl viqwrfvnrv qkqmnafleg ftellpidli kifdenelel lmcglgdvdv
      721 ndwrqhsiyk ngycpnhpvi qwfwkavllm daekrirllq fvtgtsrvpm ngfaelygsn
      781 gpqlftieqw gspeklprah tcfnrldlpp yetfedlrek llmavenaqg fegvd
//
LOCUS       NP_033874                707 aa            linear   ROD 27-AUG-2025
DEFINITION  B-cell lymphoma 6 protein homolog isoform 1 [Mus musculus].
ACCESSION   NP_033874
VERSION     NP_033874.1
DBSOURCE    REFSEQ: accession NM_009744.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 707)
  AUTHORS   Gribonika,I., Band,V.I., Chi,L., Perez-Chaparro,P.J., Link,V.M.,
            Ansaldo,E., Oguz,C., Bousbaine,D., Fischbach,M.A. and Belkaid,Y.
  TITLE     Skin autonomous antibody production regulates host-microbiota
            interactions
  JOURNAL   Nature 638 (8052), 1043-1053 (2025)
   PUBMED   39662506
  REMARK    Erratum:[Nature. 2025 Mar;639(8053):E6. doi:
            10.1038/s41586-025-08776-8. PMID: 39972149]
REFERENCE   2  (residues 1 to 707)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   3  (residues 1 to 707)
  AUTHORS   Fahlquist-Hagert,C., Wittenborn,T.R., Pedersen,M.K., Jensen,L. and
            Degn,S.E.
  TITLE     T-follicular regulatory cells expand to control germinal center
            plasma cell output but fail to curb autoreactivity
  JOURNAL   iScience 27 (10), 110887 (2024)
   PUBMED   39319261
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 707)
  AUTHORS   Li,Y., Ramirez-Suastegui,C., Harris,R., Castaneda-Castro,F.E.,
            Ascui,G., Perez-Jeldres,T., Diaz,A., Morong,C., Giles,D.A.,
            Chai,J., Seumois,G., Sanchez-Elsner,T., Cummings,F., Kronenberg,M.
            and Vijayanand,P.
  TITLE     Stem-like T cells are associated with the pathogenesis of
            ulcerative colitis in humans
  JOURNAL   Nat Immunol 25 (7), 1231-1244 (2024)
   PUBMED   38898157
REFERENCE   5  (residues 1 to 707)
  AUTHORS   Dent,A.L., Shaffer,A.L., Yu,X., Allman,D. and Staudt,L.M.
  TITLE     Control of inflammation, cytokine expression, and germinal center
            formation by BCL-6
  JOURNAL   Science 276 (5312), 589-592 (1997)
   PUBMED   9110977
REFERENCE   6  (residues 1 to 707)
  AUTHORS   Bernardin,F., Collyn-d'Hooghe,M., Quief,S., Bastard,C., Leprince,D.
            and Kerckaert,J.P.
  TITLE     Small deletions occur in highly conserved regions of the LAZ3/BCL6
            major translocation cluster in one case of non-Hodgkin's lymphoma
            without 3q27 translocation
  JOURNAL   Oncogene 14 (7), 849-855 (1997)
   PUBMED   9047392
REFERENCE   7  (residues 1 to 707)
  AUTHORS   Yoshida,T., Fukuda,T., Okabe,S., Hatano,M., Miki,T., Hirosawa,S.,
            Miyasaka,N., Isono,K. and Tokuhisa,T.
  TITLE     The BCL6 gene is predominantly expressed in keratinocytes at their
            terminal differentiation stage
  JOURNAL   Biochem Biophys Res Commun 228 (1), 216-220 (1996)
   PUBMED   8912662
REFERENCE   8  (residues 1 to 707)
  AUTHORS   Liao,X., Gilbert,D.J., Dent,A., Staudt,L.M., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Mapping of the mouse Bcl6 gene to chromosome 16
  JOURNAL   Mamm Genome 7 (8), 621-622 (1996)
   PUBMED   8678989
REFERENCE   9  (residues 1 to 707)
  AUTHORS   Allman,D., Jain,A., Dent,A., Maile,R.R., Selvaggi,T., Kehry,M.R.
            and Staudt,L.M.
  TITLE     BCL-6 expression during B-cell activation
  JOURNAL   Blood 87 (12), 5257-5268 (1996)
   PUBMED   8652841
REFERENCE   10 (residues 1 to 707)
  AUTHORS   Fukuda,T., Miki,T., Yoshida,T., Hatano,M., Ohashi,K., Hirosawa,S.
            and Tokuhisa,T.
  TITLE     The murine BCL6 gene is induced in activated lymphocytes as an
            immediate early gene
  JOURNAL   Oncogene 11 (8), 1657-1663 (1995)
   PUBMED   7478591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158397.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039228.1, BC052315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 15.26 cM"
     Protein         1..707
                     /product="B-cell lymphoma 6 protein homolog isoform 1"
                     /note="B-cell lymphoma 6 protein homolog; B-cell
                     leukemia/lymphoma 5"
                     /calculated_mol_wt=78851
     Region          8..125
                     /region_name="BTB_POZ_ZBTB27_BCL6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in B-cell lymphoma
                     6 protein (BCL-6); cd18331"
                     /db_xref="CDD:349640"
     Site            order(8..14,17..18,21,24,28,51..55,58,114..116,120)
                     /site_type="other"
                     /note="co-repressor binding site [polypeptide binding]"
                     /db_xref="CDD:349640"
     Site            order(8..11,14..16,18..19,21..22,25,28,30..31,46..48,
                     51..53,58,67,89..90,93..97,116,120)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:349640"
     Site            order(21,24..25,28,51..55,58,113..115)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:349640"
     Region          <179..429
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          275..350
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK1.
                     /evidence=ECO:0000250|UniProtKB:P41182; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          377..380
                     /region_name="Required for interaction with NuRD complex
                     and for transcriptional repressor activity"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            380
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P41182; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          405..469
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            405
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          521..542
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          561..586
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          577..597
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(582,584,586,588..589,592..593,596,610,612,616..617,
                     620..621,624,638,640,642,644..645,648..649,652)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          589..614
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          605..625
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          617..642
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          633..653
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          646..670
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          661..679
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..707
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /coded_by="NM_009744.5:110..2233"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28082.1"
                     /db_xref="GeneID:12053"
                     /db_xref="MGI:MGI:107187"
ORIGIN      
        1 maspadsciq ftrhasdvll nlnrlrsrdi ltdvvivvsr eqfrahktvl macsglfysi
       61 ftdqlkcnls vinldpeisp egfcilldfm ytsrlnlreg nimavmttam ylqmehvvdt
      121 crkfikasea emapalkppr eeflnsrmlm phdimayrgr evvennmplr ntpgcesraf
      181 applysglst ppasypmysh lplstflfsd eelrdaprmp vanpfpkera lpcdsarqvp
      241 neysrpamev spslchsniy spkeavpeea rsdihysvpe gpkpavpsar napyfpcdka
      301 skeeerpsse deialhfepp naplnrkglv spqspqksdc qpnsptescs sknacilqas
      361 gsppaksptd pkacnwkkyk fivlnslnqn akpegseqae lgrlsprayp appacqppme
      421 panldlqspt klsasgedst ipqasrlnnl vnrslagspr ssseshsply mhppkctscg
      481 sqspqhtemc lhtagptfpe emgetqseys dsscengtff cnecdcrfse easlkrhtlq
      541 thsdkpykcd rcqasfrykg nlashktvht gekpyrcnic gaqfnrpanl kthtrihsge
      601 kpykcetcga rfvqvahlra hvlihtgekp ypceicgtrf rhlqtlkshl rihtgekpyh
      661 cekcnlhfrh ksqlrlhlrq khgaitntkv qyrvsaadlp pelpkac
//
LOCUS       NP_031903                446 aa            linear   ROD 27-AUG-2025
DEFINITION  D(3) dopamine receptor [Mus musculus].
ACCESSION   NP_031903
VERSION     NP_031903.1
DBSOURCE    REFSEQ: accession NM_007877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Matsuda,M., Nishi,T., Yoshida,Y., Terada,Y., Matsuda-Hayama,C.,
            Kumamoto,T., Hamamura,K., Kohro-Ikeda,E., Yasuo,S., Koyanagi,S.,
            Matsunaga,N. and Ohdo,S.
  TITLE     Dopamine receptor D3 affects the expression of Period1 in mouse
            cells via DRD3-ERK-CREB signaling
  JOURNAL   Biochem Biophys Res Commun 752, 151470 (2025)
   PUBMED   39954359
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Enriquez-Traba,J., Arenivar,M., Yarur-Castillo,H.E., Noh,C.,
            Flores,R.J., Weil,T., Roy,S., Usdin,T.B., LaGamma,C.T., Wang,H.,
            Tsai,V.S., Kerspern,D., Moritz,A.E., Sibley,D.R., Lutas,A.,
            Moratalla,R., Freyberg,Z. and Tejeda,H.A.
  TITLE     Dissociable control of motivation and reinforcement by distinct
            ventral striatal dopamine receptors
  JOURNAL   Nat Neurosci 28 (1), 105-121 (2025)
   PUBMED   39653808
REFERENCE   3  (residues 1 to 446)
  AUTHORS   Tropea,M.R., Melone,M., Li Puma,D.D., Vacanti,V., Aceto,G.,
            Bandiera,B., Trovato,R.C., Torrisi,S.A., Leggio,G.M., Palmeri,A.,
            D'Ascenzo,M., Conti,F., Grassi,C. and Puzzo,D.
  TITLE     Blockade of dopamine D3 receptors improves hippocampal synaptic
            function and rescues age-related cognitive phenotype
  JOURNAL   Aging Cell 23 (11), e14291 (2024)
   PUBMED   39236310
REFERENCE   4  (residues 1 to 446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 446)
  AUTHORS   Peng,H.R., Qiu,J.Q., Zhou,Q.M., Zhang,Y.K., Chen,Q.Y., Yin,Y.Q.,
            Su,W., Yu,S., Wang,Y.T., Cai,Y., Gu,M.N., Zhang,H.H., Sun,Q.Q.,
            Hu,G., Wu,Y.W., Liu,J., Chen,S., Zhu,Z.J., Song,X.Y. and Zhou,J.W.
  TITLE     Intestinal epithelial dopamine receptor signaling drives
            sex-specific disease exacerbation in a mouse model of multiple
            sclerosis
  JOURNAL   Immunity 56 (12), 2773-2789 (2023)
   PUBMED   37992711
REFERENCE   6  (residues 1 to 446)
  AUTHORS   Baik,J.H., Picetti,R., Saiardi,A., Thiriet,G., Dierich,A.,
            Depaulis,A., Le Meur,M. and Borrelli,E.
  TITLE     Parkinsonian-like locomotor impairment in mice lacking dopamine D2
            receptors
  JOURNAL   Nature 377 (6548), 424-428 (1995)
   PUBMED   7566118
REFERENCE   7  (residues 1 to 446)
  AUTHORS   Fu,D., Skryabin,B.V., Brosius,J. and Robakis,N.K.
  TITLE     Molecular cloning and characterization of the mouse dopamine D3
            receptor gene: an additional intron and an mRNA variant
  JOURNAL   DNA Cell Biol 14 (6), 485-492 (1995)
   PUBMED   7598803
REFERENCE   8  (residues 1 to 446)
  AUTHORS   Scott,A.W., Griffin,S.A. and Luedtke,R.R.
  TITLE     Genetic polymorphisms at the rat and murine loci coding for
            dopamine D2-like receptors
  JOURNAL   Brain Res Mol Brain Res 29 (2), 347-357 (1995)
   PUBMED   7609622
REFERENCE   9  (residues 1 to 446)
  AUTHORS   Park,B.H., Fishburn,C.S., Carmon,S., Accili,D. and Fuchs,S.
  TITLE     Structural organization of the murine D3 dopamine receptor gene
  JOURNAL   J Neurochem 64 (2), 482-486 (1995)
   PUBMED   7830039
REFERENCE   10 (residues 1 to 446)
  AUTHORS   Crabbe,J.C., Belknap,J.K., Mitchell,S.R. and Crawshaw,L.I.
  TITLE     Quantitative trait loci mapping of genes that influence the
            sensitivity and tolerance to ethanol-induced hypothermia in BXD
            recombinant inbred mice
  JOURNAL   J Pharmacol Exp Ther 269 (1), 184-192 (1994)
   PUBMED   8169823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137819.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119286.1, X67274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     Protein         1..446
                     /product="D(3) dopamine receptor"
                     /note="dopamine D3 receptor; dopamine receptor 3"
                     /calculated_mol_wt=49538
     Site            12
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30728.1)"
     Site            19
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30728.1)"
     Region          30..440
                     /region_name="7tmA_D3_dopamine_R"
                     /note="D3 subtype of the D2-like family of dopamine
                     receptors, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15310"
                     /db_xref="CDD:320436"
     Region          31..57
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320436"
     Site            33..55
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Region          64..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320436"
     Site            66..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30728.1)"
     Region          103..133
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320436"
     Site            105..126
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Site            order(106,110..111,114,189,192..193,391..392,395,411,415,
                     419)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:320436"
     Site            150..170
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Region          150..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320436"
     Site            173
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30728.1)"
     Region          185..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320436"
     Site            188..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Region          368..398
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320436"
     Site            376..397
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     Region          408..433
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320436"
     Site            413..432
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30728.1)"
     CDS             1..446
                     /gene="Drd3"
                     /gene_synonym="D3R"
                     /coded_by="NM_007877.2:22..1362"
                     /db_xref="CCDS:CCDS28179.1"
                     /db_xref="GeneID:13490"
                     /db_xref="MGI:MGI:94925"
ORIGIN      
        1 maplsqissh instcgaens tgvnrarpha yyalsycali laiifgnglv caavlreral
       61 qtttnylvvs lavadllvat lvmpwvvyle vtggvwnfsr iccdvfvtld vmmctasiln
      121 lcaisidryt avvmpvhyqh gtgqsscrrv almitavwvl afavscpllf gfnttgdpsi
      181 csisnpdfvi yssvvsfyvp fgvtvlvyar iymvlrqrrr kriltrqnsq cisirpgfpq
      241 qssclrlhpi rqfsirarfl sdatgqmehi edkpypqkcq dpllshlqpl spgqthgelk
      301 ryysicqdta lrhpnfeggg gmsqvertrn slsptmapkl slevrklsng rlstslklgp
      361 lqprgvplre kkatqmvviv lgafivcwlp fflthvlnth cqachvspel yrattwlgyv
      421 nsalnpviyt tfniefrkaf lkilsc
//
LOCUS       NP_001399548             164 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform d [Mus musculus].
ACCESSION   NP_001399548
VERSION     NP_001399548.1
DBSOURCE    REFSEQ: accession NM_001412619.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 164)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 164)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 164)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 164)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 164)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 164)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 164)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 164)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 164)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 164)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.1221753.1,
                                           SRR17784644.433980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..164
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..164
                     /product="synaptosomal-associated protein 25 isoform d"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=18566
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          101..159
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(101,103..104,107..112,114..115,118..119,121..123,
                     125..126,129..130,132..133,135..140,142..143,146,149,153,
                     156,159)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            132
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     CDS             1..164
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001412619.1:210..704"
                     /note="isoform d is encoded by transcript variant 10"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqleri
       61 eegmdqinkd mkeaeknltd lgkfcglcvc pcnkvtndar enemdenleq vsgiignlrh
      121 maldmgneid tqnrqidrim ekadsnktri deanqratkm lgsg
//
LOCUS       NP_001074397             485 aa            linear   ROD 27-AUG-2025
DEFINITION  recombining binding protein suppressor of hairless isoform 3 [Mus
            musculus].
ACCESSION   NP_001074397
VERSION     NP_001074397.1
DBSOURCE    REFSEQ: accession NM_001080928.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Chen,K.Y., Kibayashi,T., Giguelay,A., Hata,M., Nakajima,S.,
            Mikami,N., Takeshima,Y., Ichiyama,K., Omiya,R., Ludwig,L.S.,
            Hattori,K. and Sakaguchi,S.
  TITLE     Genome-wide CRISPR screen in human T cells reveals regulators of
            FOXP3
  JOURNAL   Nature 642 (8066), 191-200 (2025)
   PUBMED   40140585
  REMARK    Erratum:[Nature. 2025 Jul;643(8074):E25. doi:
            10.1038/s41586-025-09356-6. PMID: 40640568]
REFERENCE   3  (residues 1 to 485)
  AUTHORS   O'Hara,J., Dakle,P., Nguyen,M.L.T., Barugahare,A., Bennett,T.J.,
            Udupa,V.A., Murray,N., Schlegel,G., Kapouleas,C., Li,J.,
            Turner,S.J. and Russ,B.E.
  TITLE     Notch dependent chromatin remodeling enables Gata3 binding and
            drives lineage specific CD8+ T cell function
  JOURNAL   Immunol Cell Biol 103 (4), 365-382 (2025)
   PUBMED   40012375
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Nakisli,S., Fanelli,K., LaComb,J., Arnold,L.J. and Nielsen,C.M.
  TITLE     CNS resident macrophages exhibit region-specific states and
            immunogenic responses during Rbpj-deficient brain arteriovenous
            malformation
  JOURNAL   Sci Rep 15 (1), 3932 (2025)
   PUBMED   39890825
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Jarriault,S., Brou,C., Logeat,F., Schroeter,E.H., Kopan,R. and
            Israel,A.
  TITLE     Signalling downstream of activated mammalian Notch
  JOURNAL   Nature 377 (6547), 355-358 (1995)
   PUBMED   7566092
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Hamaguchi,Y., Mastunami,N., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     Cloning and characterization of a protein binding to the J kappa
            recombination signal sequence of immunoglobulin genes
  JOURNAL   Adv Exp Med Biol 292, 177-186 (1991)
   PUBMED   1950768
REFERENCE   9  (residues 1 to 485)
  AUTHORS   Matsunami,N., Hamaguchi,Y., Yamamoto,Y., Kuze,K., Kangawa,K.,
            Matsuo,H., Kawaichi,M. and Honjo,T.
  TITLE     A protein binding to the J kappa recombination sequence of
            immunoglobulin genes contains a sequence related to the integrase
            motif
  JOURNAL   Nature 342 (6252), 934-937 (1989)
   PUBMED   2556644
REFERENCE   10 (residues 1 to 485)
  AUTHORS   Siminovitch,K.A., Moore,M.W., Durdik,J. and Selsing,E.
  TITLE     The human kappa deleting element and the mouse recombining segment
            share DNA sequence homology
  JOURNAL   Nucleic Acids Res 15 (6), 2699-2705 (1987)
   PUBMED   3104881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB839243.1, AC084054.12, CD540070.1, AK028363.1 and AK132145.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) is shorter and has a distinct N-terminus, compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN02146468
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.37 cM"
     Protein         1..485
                     /product="recombining binding protein suppressor of
                     hairless isoform 3"
                     /note="recombining binding protein suppressor of hairless;
                     J-kappa recombination signal binding protein; Jkappa
                     recombination signal binding protein"
                     /calculated_mol_wt=54195
     Region          33..163
                     /region_name="LAG1-DNAbind"
                     /note="LAG1, DNA binding; pfam09271"
                     /db_xref="CDD:462735"
     Region          191..313
                     /region_name="BTD"
                     /note="Beta-trefoil DNA-binding domain; pfam09270"
                     /db_xref="CDD:462734"
     Region          335..431
                     /region_name="IPT_RBP-Jkappa"
                     /note="IPT domain of the recombination signal Jkappa
                     binding protein (RBP-Jkappa). RBP-J kappa, was initially
                     considered to be involved in V(D)J recombination because
                     of its DNA binding specificity and structural similarity
                     to site-specific recombinases known...; cd01176"
                     /db_xref="CDD:238581"
     CDS             1..485
                     /gene="Rbpj"
                     /gene_synonym="CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa;
                     RBP-Jkappa; RBPjk; Rbpsuh"
                     /coded_by="NM_001080928.1:112..1569"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS51503.1"
                     /db_xref="GeneID:19664"
                     /db_xref="MGI:MGI:96522"
ORIGIN      
        1 mlayrkfger pppkrltrea mrnylkergd qtvlilhakv aqksygnekr ffcpppcvyl
       61 mgsgwkkkke qmerdgcseq esqpcafigi gnsdqemqql nlegknycta ktlyisdsdk
      121 rkhfmlsvkm fygnsddigv flskrikvis kpskkkqslk nadlciasgt kvalfnrlrs
      181 qtvstrylhv eggnfhassq qwgafyihll dddesegeef tvrdgyihyg qtvklvcsvt
      241 gmalprliir kvdkqtalld addpvsqlhk cafylkdter mylclsqeri iqfqatpcpk
      301 eqnkemindg aswtiistdk aeytfyegmg pvlapvtpvp vveslqlngg gdvamleltg
      361 qnftpnlrvw fgdveaetmy rcgesmlcvv pdisafregw rwvrqpvqvp vtlvrndgvi
      421 ystsltftyt pepgprphcs aagailrans sqvpsnesnt nsegnytnas tnstsvtsst
      481 atvvs
//
LOCUS       NP_001389664            2682 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 6 [Mus musculus].
ACCESSION   NP_001389664
VERSION     NP_001389664.1
DBSOURCE    REFSEQ: accession NM_001402735.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2682)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2682)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2682)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2682)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2682)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2682)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2682)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2682)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2682)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2682)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.36363.1,
                                           ERR3363658.2268047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2682
                     /product="adenomatous polyposis coli protein isoform 6"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=292853
     Region          66..146
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          <246..304
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          297..348
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          303..346
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(337,341,345,380,384,388,424,428,432)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          350..391
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          354..391
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          398..433
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          441..482
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          487..527
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          491..525
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          529..569
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          533..569
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          570..857
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          874..973
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1095..>1112
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1121..1207
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1475..1498
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1500..1553
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1554..1575
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1584..1677
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1711..1785
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          1872..1891
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2063..2408
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2510..2682
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2682
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402735.1:84..8132"
                     /note="isoform 6 is encoded by transcript variant 12"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 mtsgqidlle rlkefnldsn fpgvklrskm slrsygsreg svssrsgecs pvpmgsfprr
       61 tfvngsrest gyleeleker sllladldke ekekdwyyaq lqnltkrids lpltenfslq
      121 tdmtrrqley earqiraame eqlgtcqdme kraqrriari qqiekdilrv rqllqsqaae
      181 aerssqsrhd aasheagrqh eghgvaesnt aasssgqspa trvdhetasv lsssgthsap
      241 rrltshlgtk iraycetcwe wqeaheqgmd qdknpmpapv ehqicpavcv lmklsfdeeh
      301 rhamnelggl qaiaellqvd cemygltndh ysvtlrryag maltnltfgd vankatlcsm
      361 kgcmralvaq lksesedlqq viasvlrnls wradvnskkt lrevgsvkal mecalevkke
      421 stlksvlsal wnlsahcten kadicavdga laflvgtlty rsqtntlaii esgggilrnv
      481 ssliatnedh rqilrenncl qtllqhlksh sltivsnacg tlwnlsarnp kdqealwdmg
      541 avsmlknlih skhkmiamgs aaalrnlman rpakykdani mspgsslpsl hvrkqkalea
      601 eldaqhlset fdnidnlspk ashrskqrhk qnlygdyafd anrhddsrsd nfntgnmtvl
      661 spylnttvlp sssssrgsld ssrsekdrsl erergiglsa yhpttenagt sskrglqitt
      721 taaqiakvme evsaihtsqd drssasttef hcvaddrsaa rrssashths ntynftksen
      781 snrtcsmpya kveykrssnd slnsvtssdg ygkrgqmkps vesyseddes kfcsygqypa
      841 dlahkihsan hmddndgeld tpinyslkys deqlnsgrqs psqnerwarp khviedeikq
      901 neqrqarsqn tsypvysent ddkhlkfqph fgqqecvspy rsrgtsgset nrmgsshain
      961 qnvnqslcqe ddyeddkptn yseryseeeq heeeeerptn ysikyneekh hvdqpidysl
     1021 kyatdisssq kpsfsfskns saqstkpehl spssentavp psnakrqnql rpssaqrngq
     1081 tqkgttckvp sinqetiqty cvedtpicfs rcsslsslss addeigcdqt tqeadsantl
     1141 qtaevkendv trsaedpate vpavsqnara kpsrlqasgl ssestrhnka vefssgaksp
     1201 sksgaqtpks ppehyvqetp lvfsrctsvs sldsfesrsi assvqsepcs gmvsgiisps
     1261 dlpdspgqtm ppsrsktppp ppqtvqakre vpkskvpaae kresgpkqta vnaavqrvqv
     1321 lpdvdtllhf atestpdgfs cssslsalsl depfiqkdve lrimppvqen dngneteseq
     1381 peesnenqdk evekpdsekd llddsddddi eileeciisa mptkssrkak klaqtasklp
     1441 ppvarkpsql pvykllpaqn rlqaqkhvsf tpgddvprvy cvegtpinfs tatslsdlti
     1501 esppnelatg dgvragiqsg efekrdtipt egrstddaqr gkissivtpd lddnkaeegd
     1561 ilaecinsam pkgkshkpfr vkkimdqvqq asstssgank nqvdtkkkkp tspvkpmpqn
     1621 teyrtrvrkn tdskvnvnte etfsdnkdsk kpslqtnaka fneklpnned rvrgsfalds
     1681 phhytpiegt pycfsrndsl ssldfddddv dlsrekaelr kgkeskdsea kvtcrpepns
     1741 sqqaasksqa sikhpanraq skpvlqkqpt fpqsskdgpd rgaatdeklq nfaientpvc
     1801 fsrnsslssl sdidqennnn kesepikeae pansqgepsk pqasgyapks fhvedtpvcf
     1861 srnsslssls idseddllqe cissampkkk rpsrlksese kqsprkvggi laedltldlk
     1921 dlqrpdseha fspdsenfdw kaiqegansi vsslhqaaaa aaclsrqass dsdsilslks
     1981 gislgspfhl tpdqeekpft snkgprilkp gekstleakk iesenkgikg gkkvykslit
     2041 gkirsnseis sqmkqplptn mpsisrgrtm ihipglrnss sstspvskkg pplktpasks
     2101 psegpgatts prgtkpagks elspitrqts qisgsnkgss rsgsrdstps rptqqplsrp
     2161 mqspgrnsis pgrngisppn klsqlprtss pstastkssg sgkmsytspg rqlsqqnltk
     2221 qaslsknass iprsesaskg lnqmsngngs nkkvelsrms stkssgsesd rserpalvrq
     2281 stfikeapsp tlrrkleesa sfeslspssr pdsptrsqaq tpvlspslpd mslsthpsvq
     2341 aggwrklppn lsptieyndg rptkrhdiar shsespsrlp inragtwkre hskhssslpr
     2401 vstwrrtgss ssilsasses sekakseder hvssmpaprq mkenqvptkg twrkikesdi
     2461 sptgmasqsa ssgaasgaes kpliyqmapp vsktedvwvr iedcpinnpr sgrsptgntp
     2521 pvidsvsekg sssikdskdt hgkqsvgsgs pvqtvgletr lnsfvqveap eqkgteakpg
     2581 qsnpvsiaet aetciaertp fsssssskhs spsgtvaarv tpfnynpspr kssadstsar
     2641 psqiptpvst ntkkrdsktd stessgaqsp krhsgsylvt sv
//
LOCUS       NP_001415448             458 aa            linear   ROD 27-AUG-2025
DEFINITION  histone deacetylase 2 isoform b [Mus musculus].
ACCESSION   NP_001415448 XP_006512618
VERSION     NP_001415448.1
DBSOURCE    REFSEQ: accession NM_001428519.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 458)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 458)
  AUTHORS   Zrimsek,M., Draganic,K., Malzer,A., Doblmayr,V., Misura,K., de
            Freitas E Silva,R., Matthews,J.D., Iannelli,F., Wohlhaupter,S.,
            Perez Malla,C.U., Fischer,H., Schachner,H., Schiefer,A.I.,
            Sheibani-Tezerji,R., Chiarle,R., Turner,S.D., Ellmeier,W.,
            Seiser,C. and Egger,G.
  TITLE     HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large
            cell lymphoma: implications for HDAC inhibitor therapy
  JOURNAL   Leukemia 39 (6), 1412-1424 (2025)
   PUBMED   40175628
REFERENCE   3  (residues 1 to 458)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 458)
  AUTHORS   Iwamura,Y., Nakai,T., Kato,K., Ishioka,H., Yamamoto,M., Hirano,I.
            and Suzuki,N.
  TITLE     Erythropoietin Production in Embryonic Neural Cells is Controlled
            by Hypoxia Signaling and Histone Deacetylases with an
            Undifferentiated Cellular State
  JOURNAL   Mol Cell Biol 45 (1), 32-45 (2025)
   PUBMED   39620278
REFERENCE   5  (residues 1 to 458)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 458)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (residues 1 to 458)
  AUTHORS   Zeng,Y., Tang,C.M., Yao,Y.L., Yang,W.M. and Seto,E.
  TITLE     Cloning and characterization of the mouse histone deacetylase-2
            gene
  JOURNAL   J Biol Chem 273 (44), 28921-28930 (1998)
   PUBMED   9786895
REFERENCE   8  (residues 1 to 458)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   9  (residues 1 to 458)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (residues 1 to 458)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165370.4.
            
            On Mar 14, 2024 this sequence version replaced XP_006512618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.814465.1,
                                           SRR17253012.1825388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 19.44 cM"
     Protein         1..458
                     /product="histone deacetylase 2 isoform b"
                     /EC_number="3.5.1.98"
                     /note="HD2; YY1 transcription factor-binding protein;
                     protein deacylase HDAC2"
                     /calculated_mol_wt=51834
     Region          1..344
                     /region_name="Arginase_HDAC"
                     /note="Arginase-like and histone-like hydrolases; cl17011"
                     /db_xref="CDD:450134"
     Site            order(112,147,149,151,233,235,272)
                     /site_type="active"
                     /db_xref="CDD:212513"
     Site            order(147,149,235)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:212513"
     CDS             1..458
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /coded_by="NM_001428519.1:831..2207"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="GeneID:15182"
                     /db_xref="MGI:MGI:1097691"
ORIGIN      
        1 mkphrirmth nlllnyglyr kmeiyrphka taeemtkyhs deyikflrsi rpdnmseysk
       61 qmqrfnvged cpvfdglfef cqlstggsva gavklnrqqt dmavnwaggl hhakkseasg
      121 fcyvndivla ilellkyhqr vlyididihh gdgveeafyt tdrvmtvsfh kygeyfpgtg
      181 dlrdigagkg kyyavnfpmr dgiddesygq ifkpiiskvm emyqpsavvl qcgadslsgd
      241 rlgcfnltvk ghakcvevvk tfnlpllmlg gggytirnva rcwtyetava ldceipnelp
      301 yndyfeyfgp dfklhispsn mtnqntpeym ekikqrlfen lrmlphapgv qmqaipedav
      361 hedsgdedge dpdkrisira sdkriacdee fsdsedegeg grrnvadhkk gakkarieed
      421 kketedkktd vkeedkskdn sgektdpkga kseqlsnp
//
LOCUS       NP_001405746             105 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 12 [Mus musculus].
ACCESSION   NP_001405746
VERSION     NP_001405746.1
DBSOURCE    REFSEQ: accession NM_001418817.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 105)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 105)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 105)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 105)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 105)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 105)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 105)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 105)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 105)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 105)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1509585.1,
                                           SRR7345562.3190833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..105
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..105
                     /product="COMM domain-containing protein 10 isoform 12"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=11847
     Region          <2..104
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..105
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418817.1:914..1231"
                     /note="isoform 12 is encoded by transcript variant 13"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 mihlrkdkae afasawsamg qetvekfrqr ilgphkletv gwqlnlqmah saqaklqspq
       61 avlqlgvske daknvekvlv efnhkelfdf ynkletiqaq ldslt
//
LOCUS       NP_001412523             687 aa            linear   ROD 27-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform 4 [Mus
            musculus].
ACCESSION   NP_001412523
VERSION     NP_001412523.1
DBSOURCE    REFSEQ: accession NM_001425594.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 687)
  AUTHORS   He,W., Marchuk,H., Koeberl,D., Kasumov,T., Chen,X. and Zhang,G.F.
  TITLE     Fasting alleviates metabolic alterations in mice with propionyl-CoA
            carboxylase deficiency due to Pcca mutation
  JOURNAL   Commun Biol 7 (1), 659 (2024)
   PUBMED   38811689
  REMARK    GeneRIF: Fasting alleviates metabolic alterations in mice with
            propionyl-CoA carboxylase deficiency due to Pcca mutation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 687)
  AUTHORS   Soria,L.R., Makris,G., D'Alessio,A.M., De Angelis,A., Boffa,I.,
            Pravata,V.M., Rufenacht,V., Attanasio,S., Nusco,E., Arena,P.,
            Ferenbach,A.T., Paris,D., Cuomo,P., Motta,A., Nitzahn,M.,
            Lipshutz,G.S., Martinez-Pizarro,A., Richard,E., Desviat,L.R.,
            Haberle,J., van Aalten,D.M.F. and Brunetti-Pierri,N.
  TITLE     O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and
            promotes ureagenesis
  JOURNAL   Nat Commun 13 (1), 5212 (2022)
   PUBMED   36064721
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 687)
  AUTHORS   Subramanian,C., Frank,M.W., Tangallapally,R., Yun,M.K., Edwards,A.,
            White,S.W., Lee,R.E., Rock,C.O. and Jackowski,S.
  TITLE     Pantothenate kinase activation relieves coenzyme A sequestration
            and improves mitochondrial function in mice with propionic acidemia
  JOURNAL   Sci Transl Med 13 (611), eabf5965 (2021)
   PUBMED   34524863
REFERENCE   5  (residues 1 to 687)
  AUTHORS   Jiang,L., Park,J.S., Yin,L., Laureano,R., Jacquinet,E., Yang,J.,
            Liang,S., Frassetto,A., Zhuo,J., Yan,X., Zhu,X., Fortucci,S.,
            Hoar,K., Mihai,C., Tunkey,C., Presnyak,V., Benenato,K.E.,
            Lukacs,C.M., Martini,P.G.V. and Guey,L.T.
  TITLE     Dual mRNA therapy restores metabolic function in long-term studies
            in mice with propionic acidemia
  JOURNAL   Nat Commun 11 (1), 5339 (2020)
   PUBMED   33087718
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 687)
  AUTHORS   Guenzel,A.J., Hofherr,S.E., Hillestad,M., Barry,M., Weaver,E.,
            Venezia,S., Kraus,J.P., Matern,D. and Barry,M.A.
  TITLE     Generation of a hypomorphic model of propionic acidemia amenable to
            gene therapy testing
  JOURNAL   Mol Ther 21 (7), 1316-1323 (2013)
   PUBMED   23648696
REFERENCE   7  (residues 1 to 687)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (residues 1 to 687)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 687)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 687)
  AUTHORS   Miyazaki,T., Ohura,T., Kobayashi,M., Shigematsu,Y., Yamaguchi,S.,
            Suzuki,Y., Hata,I., Aoki,Y., Yang,X., Minjares,C., Haruta,I.,
            Uto,H., Ito,Y. and Muller,U.
  TITLE     Fatal propionic acidemia in mice lacking propionyl-CoA carboxylase
            and its rescue by postnatal, liver-specific supplementation via a
            transgene
  JOURNAL   J Biol Chem 276 (38), 35995-35999 (2001)
   PUBMED   11461925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144798.4, AC169511.1 and AC154499.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.205799.1,
                                           SRR13422601.491035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.99 cM"
     Protein         1..687
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform 4"
                     /EC_number="6.4.1.3"
                     /note="propionyl-CoA carboxylase alpha chain,
                     mitochondrial; propanoyl-CoA:carbon dioxide ligase subunit
                     alpha; propionyl CoA-carboxylase alpha; PCCase subunit
                     alpha"
                     /calculated_mol_wt=75618
     CDS             1..687
                     /gene="Pcca"
                     /coded_by="NM_001425594.1:37..2100"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /db_xref="GeneID:110821"
                     /db_xref="MGI:MGI:97499"
ORIGIN      
        1 magqwvrtva llaarrhwrr ssqqqllgtl khapvysyqc lvvsrslssv eyepkektfd
       61 kilianrgei acrviktckk mgiktvaihs dvdassvhvk madeavcvgp aptsksylnm
      121 daimeaikkt raqavhpgyg flsenkefak rlaaedvtfi gpdthaiqam gdkiesklla
      181 krakvntipg fdgvvkdade avriareigy pvmikasagg ggkgmriawd deetrdgfrf
      241 ssqeaassfg ddrlliekfi dnprhieiqv lgdkhgnalw lnerecsiqr rnqkvveeap
      301 sifldpetrq amgeqavala kavkyssagt veflvdsqkn fyflemntrl qvehpvteci
      361 tgldlvqemi lvakgyplrh kqedipisgw avecrvyaed pyksfglpsi grlsqyqepi
      421 hlpgvrvdsg iqpgsdisiy ydpmisklvt ygsdraealk rmedaldnyv irghtltlse
      481 rnqllaiass vfvasqlraq rfqehsrvpv irpdvakwel svklhdedht vvasnngpaf
      541 tvevdgskln vtstwnlasp llsvnvdgtq rtvqclsrea ggnmsiqflg tvykvhiltk
      601 laaelnkfml ekvpkdtsst lcspmpgvvv avsvkpgdmv aegqeicvie amkmqnsmta
      661 gkmgkvklvh ckagdtvgeg dllvele
//
LOCUS       NP_031498                269 aa            linear   ROD 27-AUG-2025
DEFINITION  aquaporin-1 [Mus musculus].
ACCESSION   NP_031498
VERSION     NP_031498.1
DBSOURCE    REFSEQ: accession NM_007472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 269)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 269)
  AUTHORS   Shihan,M.H., Balasubramanian,R., Wang,Y., Rafi,R., Faranda,A.P.,
            Parreno,J., Varadaraj,K., Gao,J., Mathias,R.T., Nie,X. and
            Duncan,M.K.
  TITLE     CD24 is required for sustained transparency of the adult lens
  JOURNAL   Exp Eye Res 255, 110347 (2025)
   PUBMED   40112946
REFERENCE   3  (residues 1 to 269)
  AUTHORS   Chung,E., Nosrati,F., Adam,M., Potter,A., Sayed,M., Ahn,C.,
            Humphreys,B.D., Lim,H.W., Hu,Y.C., Potter,S.S. and Park,J.S.
  TITLE     Proximal Tubule Cells Contribute to the Thin Descending Limb of the
            Loop of Henle during Mouse Kidney Development
  JOURNAL   J Am Soc Nephrol (2025) In press
   PUBMED   40327839
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 269)
  AUTHORS   Lv,W., Liao,J., Li,C., Liu,D., Luo,X., Diao,R., Wang,Y. and Jin,Y.
  TITLE     Aquaporin 1 is renoprotective in septic acute kidney injury by
            attenuating inflammation, apoptosis and fibrosis through inhibition
            of P53 expression
  JOURNAL   Front Immunol 15, 1443108 (2024)
   PUBMED   39238634
  REMARK    GeneRIF: Aquaporin 1 is renoprotective in septic acute kidney
            injury by attenuating inflammation, apoptosis and fibrosis through
            inhibition of P53 expression.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 269)
  AUTHORS   Ma,Y.S., Deng,S.Q., Zhang,P., Thomsen,J.S., Andreasen,A.,
            Chang,S.J., Zhang,J., Gu,L. and Zhai,X.Y.
  TITLE     Identification of countercurrent tubule-vessel arrangements in the
            early development of mouse kidney based on immunohistochemistry and
            computer-assisted 3D visualization
  JOURNAL   PLoS One 19 (8), e0307223 (2024)
   PUBMED   39137214
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 269)
  AUTHORS   Ma,T., Yang,B., Gillespie,A., Carlson,E.J., Epstein,C.J. and
            Verkman,A.S.
  TITLE     Severely impaired urinary concentrating ability in transgenic mice
            lacking aquaporin-1 water channels
  JOURNAL   J Biol Chem 273 (8), 4296-4299 (1998)
   PUBMED   9468475
REFERENCE   7  (residues 1 to 269)
  AUTHORS   Moon,C., King,L.S. and Agre,P.
  TITLE     Aqp1 expression in erythroleukemia cells: genetic regulation of
            glucocorticoid and chemical induction
  JOURNAL   Am J Physiol 273 (5), C1562-C1570 (1997)
   PUBMED   9374641
REFERENCE   8  (residues 1 to 269)
  AUTHORS   Ruiz,A. and Bok,D.
  TITLE     Characterization of the 3' UTR sequence encoded by the AQP-1 gene
            in human retinal pigment epithelium
  JOURNAL   Biochim Biophys Acta 1282 (2), 174-178 (1996)
   PUBMED   8703970
REFERENCE   9  (residues 1 to 269)
  AUTHORS   Moon,C., Williams,J.B., Preston,G.M., Copeland,N.G., Gilbert,D.J.,
            Nathans,D., Jenkins,N.A. and Agre,P.
  TITLE     The mouse aquaporin-1 gene
  JOURNAL   Genomics 30 (2), 354-357 (1995)
   PUBMED   8586439
REFERENCE   10 (residues 1 to 269)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850287.1 and AK081886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081886.1, AK158389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.38 cM"
     Protein         1..269
                     /product="aquaporin-1"
                     /EC_number="2.7.1.21"
                     /note="DER2; AQP-1; aquaporin-CHIP; delayed early response
                     protein 2; water channel protein for red blood cells and
                     kidney proximal tubule; growth factor-induced delayed
                     early response protein"
                     /calculated_mol_wt=28662
     Region          4..227
                     /region_name="MIP"
                     /note="Major intrinsic protein; pfam00230"
                     /db_xref="CDD:395174"
     Site            12..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            47..65
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            order(56,74..76,188..189,192,195)
                     /site_type="active"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     Site            order(76..78,192..194)
                     /site_type="other"
                     /note="Asn-Pro-Ala signature motifs"
                     /db_xref="CDD:238204"
     Region          76..78
                     /region_name="NPA 1.
                     /evidence=ECO:0000250|UniProtKB:P29972"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            91..109
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            134..153
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            164..181
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Region          192..194
                     /region_name="NPA 2.
                     /evidence=ECO:0000250|UniProtKB:P29972"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            205
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q02013.3)"
     Site            207..224
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02013.3)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q02013.3)"
     Site            253
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q02013.3)"
     Site            262
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q02013.3)"
     CDS             1..269
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /coded_by="NM_007472.2:193..1002"
                     /db_xref="CCDS:CCDS20164.1"
                     /db_xref="GeneID:11826"
                     /db_xref="MGI:MGI:103201"
ORIGIN      
        1 maseikkklf wravvaefla mtlfvfisig salgfnyple rnqtlvqdnv kvslafglsi
       61 atlaqsvghi sgahlnpavt lglllscqis ilravmyiia qcvgaivata ilsgitsslv
      121 dnslgrndla hgvnsgqglg ieiigtlqlv lcvlattdrr rrdlggsapl aiglsvalgh
      181 llaidytgcg inparsfgsa vltrnfsnhw ifwvgpfigg alavliydfi laprssdftd
      241 rmkvwtsgqv eeydldaddi nsrvemkpk
//
LOCUS       NP_001345783             896 aa            linear   ROD 27-AUG-2025
DEFINITION  cytokine receptor common subunit beta precursor [Mus musculus].
ACCESSION   NP_001345783 XP_006520450
VERSION     NP_001345783.1
DBSOURCE    REFSEQ: accession NM_001358854.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 896)
  AUTHORS   Costa-Pereira,S., Lanzinger,M., Nunez,N., Villar-Vesga,J.,
            Andreadou,M., Prisco,F., Hane,P., Roussel,E., Krishnarajah,S.,
            Chanel Lindemann,R., Oberbichler,L., Westermann,F., Da Silva,A.F.,
            Cecconi,V., Pinzger,M., Tugues,S., Mundt,S., Greter,M., De Feo,D.
            and Becher,B.
  TITLE     Regulatory T cells suppress GM-CSF-producing T helper cells via
            IL-2 modulation to restrain immunopathology
  JOURNAL   Cell Rep 44 (5), 115642 (2025)
   PUBMED   40315053
REFERENCE   2  (residues 1 to 896)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   3  (residues 1 to 896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 896)
  AUTHORS   Arumugam,P., Carey,B.C., Wikenheiser-Brokamp,K.A., Krischer,J.,
            Wessendarp,M., Shima,K., Chalk,C., Stock,J., Ma,Y., Black,D.,
            Imbrogno,M., Collins,M., Kalenda Yombo,D.J., Sakthivel,H.,
            Suzuki,T., Lutzko,C., Cancelas,J.A., Adams,M., Hoskins,E.,
            Lowe-Daniels,D., Reeves,L., Kaiser,A. and Trapnell,B.C.
  TITLE     A toxicology study of Csf2ra complementation and pulmonary
            macrophage transplantation therapy of hereditary PAP in mice
  JOURNAL   Mol Ther Methods Clin Dev 32 (2), 101213 (2024)
   PUBMED   38596536
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 896)
  AUTHORS   Palani,S., Uddin,M.B., McKelvey,M., Shao,S. and Sun,K.
  TITLE     Immune predisposition drives susceptibility to pneumococcal
            pneumonia after mild influenza A virus infection in mice
  JOURNAL   Front Immunol 14, 1272920 (2023)
   PUBMED   37771584
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 896)
  AUTHORS   Liboi,E., Jubinsky,P., Andrews,N.C., Nathan,D.G. and
            Mathey-Prevot,B.
  TITLE     Enhanced expression of interleukin-3 and granulocyte-macrophage
            colony-stimulating factor receptor subunits in murine hematopoietic
            cells stimulated with hematopoietic growth factors
  JOURNAL   Blood 80 (5), 1183-1189 (1992)
   PUBMED   1387562
REFERENCE   7  (residues 1 to 896)
  AUTHORS   Gorman,D.M., Itoh,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Miyajima,A.
  TITLE     Chromosomal localization and organization of the murine genes
            encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3,
            granulocyte/macrophage colony-stimulating factor, and interleukin 5
            receptors
  JOURNAL   J Biol Chem 267 (22), 15842-15848 (1992)
   PUBMED   1386365
REFERENCE   8  (residues 1 to 896)
  AUTHORS   Park,L.S., Martin,U., Sorensen,R., Luhr,S., Morrissey,P.J.,
            Cosman,D. and Larsen,A.
  TITLE     Cloning of the low-affinity murine granulocyte-macrophage
            colony-stimulating factor receptor and reconstitution of a
            high-affinity receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4295-4299 (1992)
   PUBMED   1533931
REFERENCE   9  (residues 1 to 896)
  AUTHORS   Hara,T. and Miyajima,A.
  TITLE     Two distinct functional high affinity receptors for mouse
            interleukin-3 (IL-3)
  JOURNAL   EMBO J 11 (5), 1875-1884 (1992)
   PUBMED   1582416
REFERENCE   10 (residues 1 to 896)
  AUTHORS   Fung,M.C., Mak,N.K., Leung,K.N. and Hapel,A.J.
  TITLE     Distinguishing between mouse IL-3 and IL-3 receptor-like
            (IL-5/GM-CSF receptor converter) mRNAs using the polymerase chain
            reaction method
  JOURNAL   J Immunol Methods 149 (1), 97-103 (1992)
   PUBMED   1583316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL583893.17.
            
            On Dec 12, 2017 this sequence version replaced XP_006520450.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113202.1, M34397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.36 cM"
     Protein         1..896
                     /product="cytokine receptor common subunit beta precursor"
                     /note="GM-CSF/IL-3/IL-5 receptor common beta-chain; CD131
                     antigen; cytokine receptor common subunit beta;
                     GM-CSF/IL-3/IL-5 receptor common beta subunit; colony
                     stimulating factor 2 receptor, beta 1, low-affinity
                     (granulocyte-macrophage); beta c; common beta chain"
                     /calculated_mol_wt=96549
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2505
     mat_peptide     23..896
                     /product="Cytokine receptor common subunit beta.
                     /id=PRO_0000010863"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
                     /calculated_mol_wt=96549
     Site            62
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Region          <105..>252
                     /region_name="COG4733"
                     /note="Phage-related protein, tail protein J [Mobilome:
                     prophages, transposons]"
                     /db_xref="CDD:443767"
     Site            141
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Region          220..243
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Region          245..328
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     Region          346..439
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            350
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Region          428..432
                     /region_name="WSXWS motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Site            order(428..429,431..432)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            442..463
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Region          477..485
                     /region_name="Box 1 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Region          543..620
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Region          <551..809
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          658..725
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     Site            752
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Site            754
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Site            765
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (P26955.2)"
     Region          771..810
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26955.2)"
     CDS             1..896
                     /gene="Csf2rb"
                     /gene_synonym="AIC2B; Bc; CDw131; Csf2rb1; Csfgmrb; Il3r;
                     Il3rb; Il3rb1; Il5rb"
                     /coded_by="NM_001358854.1:346..3036"
                     /db_xref="CCDS:CCDS27612.1"
                     /db_xref="GeneID:12983"
                     /db_xref="MGI:MGI:1339759"
ORIGIN      
        1 mdqqmaltwg lcymalvalc wghgvteaee tvplktlqcy ndytnhiics wadtedaqgl
       61 inmtlyhqle kkqpvscels eelmwsecps shrcvprrcv ipytrfsitn edyysfrpds
      121 dlgiqlmvpl aqnvqpplpk nvsisssedr fllewsvslg daqvswlssk diefevaykr
      181 lqdswedays lhtskfqvnf epklflpnsi yaarvrtrls pgsslsgrps rwspevhwds
      241 qpgdkaqpqn lqcffdgiqs lhcswevwtq ttgsvsfglf yrpspvapee kcspvvkepp
      301 gasvytryhc slpvpepsah sqytvsvkhl eqgkfimsyn hiqmepptln ltknrdsysl
      361 hwetqkmays fiehtfqvqy kkksdsweds ktenldrahs mdlsqlepdt sycarvrvkp
      421 isnydgiwsk wseeytwktd wvmptlwivl ilvfliltll lilrfgcvsv yrtyrkwkek
      481 ipnpsksllf qdggkglwpp gsmaafatkn palqgpqsrl laeqqgesya hlednnvspl
      541 tiedpniirv ppsgpdttpa assesteqlp nvqvegptpn rprkqlpsfd fngpylgppq
      601 shslpdlpdq lgspqvggsl kpalpgsley mclppggqaq lvplsqvmgq gqamdvqcgs
      661 sletsgspsv epkenppvel smeeqeardn pvtlpissgg pegsmmasdy vtpgdpvltl
      721 ptgplstslg pslglpsaqs pslclklprv psgspalgpp gfedyvelpp svsqaakspp
      781 ghpappvass ptvipgepre evgpasphpe gllvlqqvgd ycflpglgpg slsphskpps
      841 pslcsetedl vqdlsvkkfp yqpmpqapai qffkslkhqd ylslppwdns qsgkvc
//
LOCUS       NP_033790                663 aa            linear   ROD 27-AUG-2025
DEFINITION  polyunsaturated fatty acid lipoxygenase ALOX15 [Mus musculus].
ACCESSION   NP_033790
VERSION     NP_033790.3
DBSOURCE    REFSEQ: accession NM_009660.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 663)
  AUTHORS   Fabre,P., Molina,T., Larose,J., Greffard,K., Genereux-Gamache,G.,
            Deprez,A., Mokhtari,I., Pellerito,O., Duchesne,E., Dort,J.,
            Bilodeau,J.F. and Dumont,N.A.
  TITLE     Bioactive lipid mediator class switching regulates myogenic cell
            progression and muscle regeneration
  JOURNAL   Nat Commun 16 (1), 5578 (2025)
   PUBMED   40595516
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 663)
  AUTHORS   Nargis,T., Muralidharan,C., Enriquez,J.R., Wang,J.E., Kaylan,K.B.,
            Chakraborty,A., Pratuangtham,S., Figatner,K., Nelson,J.B.,
            May,S.C., Nadler,J.L., Boxer,M.B., Maloney,D.J., Tersey,S.A. and
            Mirmira,R.G.
  TITLE     12-Lipoxygenase inhibition delays onset of autoimmune diabetes in
            human gene replacement mice
  JOURNAL   JCI Insight 9 (24), e185299 (2024)
   PUBMED   39531315
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 663)
  AUTHORS   Baker,P.J., Bohrer,A.C., Castro,E., Amaral,E.P., Snow-Smith,M.,
            Torres-Juarez,F., Gould,S.T., Queiroz,A.T.L., Fukutani,E.R.,
            Jordan,C.M., Khillan,J.S., Cho,K., Barber,D.L., Andrade,B.B.,
            Johnson,R.F., Hilligan,K.L. and Mayer-Barber,K.D.
  TITLE     The inflammatory microenvironment of the lung at the time of
            infection governs innate control of SARS-CoV-2 replication
  JOURNAL   Sci Immunol 9 (102), eadp7951 (2024)
   PUBMED   39642242
REFERENCE   4  (residues 1 to 663)
  AUTHORS   Shi,X., Zheng,Q., Wang,X., Guo,W., Lin,Z., Gao,Y., Shore,E.,
            Martin,R.C., Lv,G. and Li,Y.
  TITLE     Compromised macrophages contribute to progression of MASH to
            hepatocellular carcinoma in FGF21KO mice
  JOURNAL   Sci Adv 10 (43), eado9311 (2024)
   PUBMED   39441934
REFERENCE   5  (residues 1 to 663)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   6  (residues 1 to 663)
  AUTHORS   Sun,D. and Funk,C.D.
  TITLE     Disruption of 12/15-lipoxygenase expression in peritoneal
            macrophages. Enhanced utilization of the 5-lipoxygenase pathway and
            diminished oxidation of low density lipoprotein
  JOURNAL   J Biol Chem 271 (39), 24055-24062 (1996)
   PUBMED   8798642
REFERENCE   7  (residues 1 to 663)
  AUTHORS   van Dijk,K.W., Steketee,K., Havekes,L., Frants,R. and Hofker,M.
  TITLE     Genomic and cDNA cloning of a novel mouse lipoxygenase gene
  JOURNAL   Biochim Biophys Acta 1259 (1), 4-8 (1995)
   PUBMED   7492614
REFERENCE   8  (residues 1 to 663)
  AUTHORS   Krieg,P., Kinzig,A., Ress-Loschke,M., Vogel,S., Vanlandingham,B.,
            Stephan,M., Lehmann,W.D., Marks,F. and Furstenberger,G.
  TITLE     12-Lipoxygenase isoenzymes in mouse skin tumor development
  JOURNAL   Mol Carcinog 14 (2), 118-129 (1995)
   PUBMED   7576099
REFERENCE   9  (residues 1 to 663)
  AUTHORS   Freire-Moar,J., Alavi-Nassab,A., Ng,M., Mulkins,M. and Sigal,E.
  TITLE     Cloning and characterization of a murine macrophage lipoxygenase
  JOURNAL   Biochim Biophys Acta 1254 (1), 112-116 (1995)
   PUBMED   7811740
REFERENCE   10 (residues 1 to 663)
  AUTHORS   Chen,X.S., Kurre,U., Jenkins,N.A., Copeland,N.G. and Funk,C.D.
  TITLE     cDNA cloning, expression, mutagenesis of C-terminal isoleucine,
            genomic structure, and chromosomal localizations of murine
            12-lipoxygenases
  JOURNAL   J Biol Chem 269 (19), 13979-13987 (1994)
   PUBMED   8188678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142371.1, U04331.1 and AL596096.7.
            
            On Mar 31, 2007 this sequence version replaced NP_033790.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142371.1, L34570.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     Protein         1..663
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /EC_number="1.13.11.12"
                     /note="arachidonate 12-lipoxygenase, leukocyte-type;
                     linoleate 13S-lipoxygenase; hepoxilin A3 synthase Alox15;
                     12-LOX; 12/15-lipoxygenase; arachidonate omega-6
                     lipoxygenase"
                     /calculated_mol_wt=75314
     Region          2..112
                     /region_name="PLAT_LOX"
                     /note="PLAT domain of 12/15-lipoxygenase. As a unique
                     subfamily of the mammalian lipoxygenases, they catalyze
                     enzymatic lipid peroxidation in complex biological
                     structures via direct dioxygenation of phospholipids and
                     cholesterol esters of biomembranes and...; cd01753"
                     /db_xref="CDD:238851"
     Region          <202..654
                     /region_name="Lipoxygenase"
                     /note="pfam00305"
                     /db_xref="CDD:459754"
     CDS             1..663
                     /gene="Alox15"
                     /gene_synonym="12-LO; 12/15-LO; 15-LOX; Alox12l; L-12LO"
                     /coded_by="NM_009660.3:27..2018"
                     /db_xref="CCDS:CCDS24944.1"
                     /db_xref="GeneID:11687"
                     /db_xref="MGI:MGI:87997"
ORIGIN      
        1 mgvyrirvst gdsvyagsnn evylwligqh geaslgklfr pcrnseaefk vdvseylgpl
       61 lfvrvqkwhy lkedawfcnw isvkgpgdqg seytfpcyrw vqgtsilnlp egtgctvved
      121 sqglfrnhre eeleerrsly rwgnwkdgti lnvaatsisd lpvdqrfred krlefeasqv
      181 lgtmdtvinf pkntvtcwks lddfnyvfks ghtkmaervr nswkedaffg yqflnganpm
      241 vlkrstclpa rlvfppgmek lqaqldeelk kgtlfeadff lldgikanvi lcsqqylaap
      301 lvmlklqpdg qllpiaiqle lpktgstppp iftpldppmd wllakcwvrs sdlqlhelqa
      361 hllrghlvae vfavatmrcl psvhpvfkll vphllytmei nvrarsdlis ergffdkvms
      421 tgggghldll kqagafltys slcppddlae rglldidtcf yakdalqlwq vmnryvvgmf
      481 dlyyktdqav qddyelqswc qeiteiglqg aqdrgfptsl qsraqachfi tmciftctaq
      541 hssihlgqld wfywvpnapc tmrlpppktk datmeklmat lpnpnqstlq invvwllgrr
      601 qavmvplgqh seehfpnpea kavlkkfree laaldkeiei rnksldipye ylrpslvens
      661 vai
//
LOCUS       NP_001408094             382 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform s [Mus musculus].
ACCESSION   NP_001408094 XP_030109108
VERSION     NP_001408094.1
DBSOURCE    REFSEQ: accession NM_001421165.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 382)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 382)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 382)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 382)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 382)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 382)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 382)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 382)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 382)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 382)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109108.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.463659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..382
                     /product="ELAV-like protein 4 isoform s"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=41912
     Region          58..381
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..382
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421165.1:481..1629"
                     /note="isoform s is encoded by transcript variant 22"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mwtfrasils sqekqkcqii stmepqvsng ptsntsngps snnrncpspm qtgaatddsk
       61 tnlivnylpq nmtqeefrsl fgsigeiesc klvrdkitgq slgygfvnyi dpkdaekain
      121 tlnglrlqtk tikvsyarps sasirdanly vsglpktmtq keleqlfsqy griitsrilv
      181 dqvtgvsrgv gfirfdkrie aeeaikglng qkpsgatepi tvkfannpsq kssqallsql
      241 yqspnrrypg plhhqaqrfr lmsgpvppsa cpprfspiti dgmtslvgmn ipghtgtgwc
      301 ifvynlspds desvlwqlfg pfgavnnvkv irdfntnkck gfgfvtmtny deaamaiasl
      361 ngyrlgdrvl qvsfktnkah ks
//
LOCUS       NP_001415720             494 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor subfamily 6 group A member 1 isoform 4 [Mus
            musculus].
ACCESSION   NP_001415720 XP_011237327
VERSION     NP_001415720.1
DBSOURCE    REFSEQ: accession NM_001428791.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Neelathi,U.M., Ullah,E., George,A., Maftei,M.I., Boobalan,E.,
            Sanchez-Mendoza,D., Adams,C., McGaughey,D., Sergeev,Y.V., Ai
            Rawi,R., Naik,A., Bender,C., Maumenee,I.H., Michaelides,M.,
            Tan,T.G., Lin,S., Villasmil,R., Blain,D., Hufnagel,R.B., Arno,G.,
            Young,R.M., Guan,B. and Brooks,B.P.
  TITLE     Variants in NR6A1 cause a novel oculo vertebral renal syndrome
  JOURNAL   Nat Commun 16 (1), 6111 (2025)
   PUBMED   40610405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Chang,Y.C., Manent,J., Schroeder,J., Wong,S.F.L., Hauswirth,G.M.,
            Shylo,N.A., Moore,E.L., Achilleos,A., Garside,V., Polo,J.M.,
            Trainor,P. and McGlinn,E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Tan,P., Xue,T., Wang,Y., Hu,Z., Su,J., Yang,R., Ji,J., Ye,M.,
            Chen,Z., Huang,C. and Lu,X.
  TITLE     Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the
            development of depression-like behaviors in mice
  JOURNAL   Neuropharmacology 209, 108990 (2022)
   PUBMED   35183538
  REMARK    GeneRIF: Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to
            the development of depression-like behaviors in mice.
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Koutelou,E., Wang,L., Schibler,A.C., Chao,H.P., Kuang,X., Lin,K.,
            Lu,Y., Shen,J., Jeter,C.R., Salinger,A., Wilson,M., Chen,Y.C.,
            Atanassov,B.S., Tang,D.G. and Dent,S.Y.R.
  TITLE     USP22 controls multiple signaling pathways that are essential for
            vasculature formation in the mouse placenta
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30718289
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Kapelle,M., Kratzschmar,J., Husemann,M. and Schleuning,W.D.
  TITLE     cDNA cloning of two closely related forms of human germ cell
            nuclear factor (GCNF)
  JOURNAL   Biochim Biophys Acta 1352 (1), 13-17 (1997)
   PUBMED   9177477
REFERENCE   7  (residues 1 to 494)
  AUTHORS   Yan,Z.H., Medvedev,A., Hirose,T., Gotoh,H. and Jetten,A.M.
  TITLE     Characterization of the response element and DNA binding properties
            of the nuclear orphan receptor germ cell nuclear factor/retinoid
            receptor-related testis-associated receptor
  JOURNAL   J Biol Chem 272 (16), 10565-10572 (1997)
   PUBMED   9099702
REFERENCE   8  (residues 1 to 494)
  AUTHORS   Joos,T.O., David,R. and Dreyer,C.
  TITLE     xGCNF, a nuclear orphan receptor is expressed during neurulation in
            Xenopus laevis
  JOURNAL   Mech Dev 60 (1), 45-57 (1996)
   PUBMED   9025060
REFERENCE   9  (residues 1 to 494)
  AUTHORS   Hirose,T., O'Brien,D.A. and Jetten,A.M.
  TITLE     RTR: a new member of the nuclear receptor superfamily that is
            highly expressed in murine testis
  JOURNAL   Gene 152 (2), 247-251 (1995)
   PUBMED   7835709
REFERENCE   10 (residues 1 to 494)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935155.13 and AL844842.29.
            
            On Mar 25, 2024 this sequence version replaced XP_011237327.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2602943.1,
                                           SRR13422598.1904531.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     Protein         1..494
                     /product="nuclear receptor subfamily 6 group A member 1
                     isoform 4"
                     /note="mGCNF; retinoid receptor-related testis-specific
                     receptor; germ cell nuclear factor"
                     /calculated_mol_wt=55758
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     Region          145..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     CDS             1..494
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /coded_by="NM_001428791.1:203..1687"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
ORIGIN      
        1 merderppsg ggggggsagf leppaalppp prngfcqdel aeldpgtnge tdsltlgqgh
       61 ipvsvpddra eqrtclicgd ratglhygii scegckgffk rsicnkrvyr csrdkncvms
      121 rkqrnrcqyc rllkclqmgm nrkairedgm pggrnksigp vqiseeeier imsgqefeee
      181 anhwsnhgds dhsspgnras esnqpspgst lssrsvelng fmafrdqymg msvpphyqyi
      241 phlfsysghs pllppqarsl dpqsyslihq lmsaedlepl gtpmliedgy avtqaelfal
      301 lcrladellf rqiawikklp ffcelsikdy tcllsstwqe lillssltvy skqifgelad
      361 vtakyspsde elhrfsdegm evierliyly hkfhqlkvsn eeyacmkain flnqdirglt
      421 sasqleqlnk rywyicqdft eykythqpnr fpdlmmclpe iryiagkmvn vpleqlpllf
      481 kvvlhsckts tvke
//
LOCUS       NP_001074846            1237 aa            linear   ROD 27-AUG-2025
DEFINITION  protocadherin-9 isoform a precursor [Mus musculus].
ACCESSION   NP_001074846 XP_006518837 XP_907564
VERSION     NP_001074846.1
DBSOURCE    REFSEQ: accession NM_001081377.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1237)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1237)
  AUTHORS   Miozzo,F., Murru,L., Maiellano,G., di Iasio,I., Zippo,A.G.,
            Zambrano Avendano,A., Metodieva,V.D., Riccardi,S., D'Aliberti,D.,
            Spinelli,S., Canu,T., Chaabane,L., Hirano,S., Kas,M.J.H.,
            Francolini,M., Piazza,R., Moretto,E. and Passafaro,M.
  TITLE     Disruption of the autism-associated Pcdh9 gene leads to
            transcriptional alterations, synapse overgrowth, and defective
            network activity in the CA1
  JOURNAL   J Neurosci 44 (50) (2024) In press
   PUBMED   39557582
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1237)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1237)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (residues 1 to 1237)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   6  (residues 1 to 1237)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   7  (residues 1 to 1237)
  AUTHORS   Krishna-K,K., Hertel,N. and Redies,C.
  TITLE     Cadherin expression in the somatosensory cortex: evidence for a
            combinatorial molecular code at the single-cell level
  JOURNAL   Neuroscience 175, 37-48 (2011)
   PUBMED   21129452
REFERENCE   8  (residues 1 to 1237)
  AUTHORS   Vanhalst,K., Kools,P., Staes,K., van Roy,F. and Redies,C.
  TITLE     delta-Protocadherins: a gene family expressed differentially in the
            mouse brain
  JOURNAL   Cell Mol Life Sci 62 (11), 1247-1259 (2005)
   PUBMED   15905963
REFERENCE   9  (residues 1 to 1237)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   10 (residues 1 to 1237)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF745283.1, AC132470.3,
            AC122355.4, AC125095.3 and AC123919.4.
            
            On or before Feb 6, 2018 this sequence version replaced
            XP_006518837.1, XP_907564.2.
            
            Summary: This gene encodes a member of the protocadherin family,
            and cadherin superfamily, of transmembrane proteins containing
            cadherin domains. These proteins mediate cell adhesion in neural
            tissues in the presence of calcium. The encoded protein may be
            involved in signaling at neuronal synaptic junctions. Sharing a
            characteristic with other protocadherin genes, this gene has a
            notably large exon that encodes multiple cadherin domains and a
            transmembrane region. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a, also known as 3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.87026.1,
                                           SRR10662774.1147985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 45.8 cM"
     Protein         1..1237
                     /product="protocadherin-9 isoform a precursor"
                     /calculated_mol_wt=133595
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2568
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1237
                     /gene="Pcdh9"
                     /coded_by="NM_001081377.3:706..4419"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS36992.1"
                     /db_xref="GeneID:211712"
                     /db_xref="MGI:MGI:1306801"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf nreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtded
      601 agenkavtls ilndnenfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdidtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkalhtlvlv flyvndtagn
      781 tsyiydlirr tmetpldrni gdsgqpyqne dyltimiaiv agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqgigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqcnsysknd
     1021 nipvthqkcp gstsfhiren eeshsesqrr vtfhlpdgsq escsdsglgd hepvgsgtli
     1081 shplplvqpq defydqaspd krteadgnsd pnsdgplgpr glaeatemct qeclvlghsd
     1141 ncwmppglgp yqhpksplst fapqkewikk dklvnghtlt rawkedtnrn qfndrkqygs
     1201 neghfnnggh madiplanlk sykqaggtie spkehql
//
LOCUS       NP_033240                366 aa            linear   ROD 27-AUG-2025
DEFINITION  spermine synthase isoform 1 [Mus musculus].
ACCESSION   NP_033240
VERSION     NP_033240.3
DBSOURCE    REFSEQ: accession NM_009214.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Yorgan,T.A., Zhu,Y., Wiedemann,P., Schoneck,K., Pohl,S.,
            Schweizer,M., Amling,M., Barvencik,F., Oheim,R. and Schinke,T.
  TITLE     Inactivation of spermine synthase in mice causes osteopenia due to
            reduced osteoblast activity
  JOURNAL   J Bone Miner Res 39 (11), 1606-1620 (2024)
   PUBMED   39331754
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Akinyele,O., Munir,A., Johnson,M.A., Perez,M.S., Gao,Y.,
            Foley,J.R., Nwafor,A., Wu,Y., Murray-Stewart,T., Casero,R.A. Jr.,
            Bayir,H. and Kemaladewi,D.U.
  TITLE     Impaired polyamine metabolism causes behavioral and neuroanatomical
            defects in a mouse model of Snyder-Robinson syndrome
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38463005
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Wang,L., Li,S., Wang,K., Wang,N., Liu,Q., Sun,Z., Wang,L., Wang,L.,
            Liu,Q., Song,C. and Yang,Q.
  TITLE     Spermine enhances antiviral and anticancer responses by stabilizing
            DNA binding with the DNA sensor cGAS
  JOURNAL   Immunity 56 (2), 272-288 (2023)
   PUBMED   36724787
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Pegg,A.E. and Michael,A.J.
  TITLE     Spermine synthase
  JOURNAL   Cell Mol Life Sci 67 (1), 113-121 (2010)
   PUBMED   19859664
  REMARK    Review article
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Korhonen,V.P., Niiranen,K., Halmekyto,M., Pietila,M., Diegelman,P.,
            Parkkinen,J.J., Eloranta,T., Porter,C.W., Alhonen,L. and Janne,J.
  TITLE     Spermine deficiency resulting from targeted disruption of the
            spermine synthase gene in embryonic stem cells leads to enhanced
            sensitivity to antiproliferative drugs
  JOURNAL   Mol Pharmacol 59 (2), 231-238 (2001)
   PUBMED   11160858
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Meyer,R.A. Jr., Henley,C.M., Meyer,M.H., Morgan,P.L.,
            McDonald,A.G., Mills,C. and Price,D.K.
  TITLE     Partial deletion of both the spermine synthase gene and the Pex
            gene in the X-linked hypophosphatemic, gyro (Gy) mouse
  JOURNAL   Genomics 48 (3), 289-295 (1998)
   PUBMED   9545633
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Lorenz,B., Francis,F., Gempel,K., Boddrich,A., Josten,M.,
            Schmahl,W., Schmidt,J., Lehrach,H., Meitinger,T. and Strom,T.M.
  TITLE     Spermine deficiency in Gy mice caused by deletion of the spermine
            synthase gene
  JOURNAL   Hum Mol Genet 7 (3), 541-547 (1998)
   PUBMED   9467015
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Strom,T.M., Francis,F., Lorenz,B., Boddrich,A., Econs,M.J.,
            Lehrach,H. and Meitinger,T.
  TITLE     Pex gene deletions in Gy and Hyp mice provide mouse models for
            X-linked hypophosphatemia
  JOURNAL   Hum Mol Genet 6 (2), 165-171 (1997)
   PUBMED   9063736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058688.1 and AL663072.12.
            
            On Dec 2, 2006 this sequence version replaced NP_033240.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058688.1, AK049787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.48 cM"
     Protein         1..366
                     /product="spermine synthase isoform 1"
                     /EC_number="2.5.1.22"
                     /note="spermidine aminopropyltransferase"
                     /calculated_mol_wt=41182
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P52788; propagated from
                     UniProtKB/Swiss-Prot (P97355.1)"
     Region          21..117
                     /region_name="SpmSyn_N"
                     /note="S-adenosylmethionine decarboxylase N -terminal;
                     pfam17950"
                     /db_xref="CDD:465581"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52788; propagated from
                     UniProtKB/Swiss-Prot (P97355.1)"
     Region          123..172
                     /region_name="Spermine_synt_N"
                     /note="Spermidine synthase tetramerization domain;
                     pfam17284"
                     /db_xref="CDD:407397"
     Region          175..365
                     /region_name="Spermine_synth"
                     /note="Spermine/spermidine synthase domain; pfam01564"
                     /db_xref="CDD:396237"
     CDS             1..366
                     /gene="Sms"
                     /gene_synonym="Gy; gyro; SpmST; SPMSY"
                     /coded_by="NM_009214.4:335..1435"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS41189.1"
                     /db_xref="GeneID:20603"
                     /db_xref="MGI:MGI:109490"
ORIGIN      
        1 maaarhstld fklgakadge ailkglqsif qeqgmtesvh twqdhgylat ytnkngsfan
       61 lriyphglvl ldlqsydsdv qgkqetdsll nkieekmkel sqdstgrvkr lppivrggai
      121 drywptadgr lveydidevv ydedspyqni kilhskqfgn ililsgdvnl aesdlaytra
      181 imgsgkedyt gkdvlilggg dggilceivk lkpkmvtmve idqmvidgck kymrrtcgdv
      241 ldnlrgdcyq vliedcipvl kmyakegref dyvindltav pistspeeds twdflrlild
      301 lsmkvlkqdg kyftqgncvn ltealslyee qlgrlycpve fskeivcvps ylelwvfytv
      361 wkkakp
//
LOCUS       NP_034191                284 aa            linear   ROD 27-AUG-2025
DEFINITION  deoxyribonuclease-1 precursor [Mus musculus].
ACCESSION   NP_034191
VERSION     NP_034191.3
DBSOURCE    REFSEQ: accession NM_010061.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 284)
  AUTHORS   Englert,H., Rangaswamy,C., Kullik,G.A., Divivier,M., Gobel,J.,
            Hermans-Borgmeyer,I., Borgmeyer,U., Mowen,K.A., Beerens,M.,
            Frye,M., Mailer,R.K., Gelderblom,M., Stavrou,E.X., Preston,R.J.S.,
            Schneider,S.W., Fuchs,T.A. and Renne,T.
  TITLE     Sepsis-induced NET formation requires MYD88 but is independent of
            GSDMD and PAD4
  JOURNAL   FASEB J 39 (1), e70301 (2025)
   PUBMED   39777764
REFERENCE   2  (residues 1 to 284)
  AUTHORS   Stabach,P.R., Sims,D., Gomez-Banuelos,E., Zehentmeier,S.,
            Dammen-Brower,K., Bernhisel,A., Kujawski,S., Lopez,S.G., Petri,M.,
            Goldman,D.W., Lester,E.R., Le,Q., Ishaq,T., Kim,H., Srivastava,S.,
            Kumar,D., Pereira,J.P., Yarema,K.J., Koumpouras,F., Andrade,F. and
            Braddock,D.T.
  TITLE     A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and
            death in genetic and induced lupus models
  JOURNAL   JCI Insight 9 (14), e177003 (2024)
   PUBMED   38888971
  REMARK    GeneRIF: A dual-acting DNASE1/DNASE1L3 biologic prevents
            autoimmunity and death in genetic and induced lupus models.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 284)
  AUTHORS   Willemsen,J.F., Wenskus,J., Lenz,M., Rhode,H., Trochimiuk,M.,
            Appl,B., Pagarol-Raluy,L., Bornigen,D., Bang,C., Reinshagen,K.,
            Herrmann,M., Elrod,J. and Boettcher,M.
  TITLE     DNases improve effectiveness of antibiotic treatment in murine
            polymicrobial sepsis
  JOURNAL   Front Immunol 14, 1254838 (2024)
   PUBMED   38259485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 284)
  AUTHORS   Elrod,J., Heuer,A., Knopf,J., Schoen,J., Schonfeld,L.,
            Trochimiuk,M., Stiel,C., Appl,B., Raluy,L.P., Saygi,C., Zlatar,L.,
            Hosari,S., Royzman,D., Winkler,T.H., Lochnit,G., Leppkes,M.,
            Grutzmann,R., Schett,G., Tomuschat,C., Reinshagen,K., Herrmann,M.,
            Fuchs,T.A. and Boettcher,M.
  TITLE     Neutrophil extracellular traps and DNases orchestrate formation of
            peritoneal adhesions
  JOURNAL   iScience 26 (12), 108289 (2023)
   PUBMED   38034352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 284)
  AUTHORS   Napirei,M., Karsunky,H., Zevnik,B., Stephan,H., Mannherz,H.G. and
            Moroy,T.
  TITLE     Features of systemic lupus erythematosus in Dnase1-deficient mice
  JOURNAL   Nat Genet 25 (2), 177-181 (2000)
   PUBMED   10835632
REFERENCE   7  (residues 1 to 284)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   8  (residues 1 to 284)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 284)
  AUTHORS   Takeshita,H., Yasuda,T., Nakajima,T., Hosomi,O., Nakashima,Y. and
            Kishi,K.
  TITLE     Mouse deoxyribonuclease I (DNase I): biochemical and immunological
            characterization, cDNA structure and tissue distribution
  JOURNAL   Biochem Mol Biol Int 42 (1), 65-75 (1997)
   PUBMED   9192086
REFERENCE   10 (residues 1 to 284)
  AUTHORS   Peitsch,M.C., Irmler,M., French,L.E. and Tschopp,J.
  TITLE     Genomic organisation and expression of mouse deoxyribonuclease I
  JOURNAL   Biochem Biophys Res Commun 207 (1), 62-68 (1995)
   PUBMED   7857306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087900.19.
            
            On Nov 24, 2007 this sequence version replaced NP_034191.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014718.1, SRR5189670.55902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.37 cM"
     Protein         1..284
                     /product="deoxyribonuclease-1 precursor"
                     /EC_number="3.1.21.1"
                     /note="deoxyribonuclease-1"
                     /calculated_mol_wt=29666
     sig_peptide     1..22
                     /note="/evidence=ECO:0000250|UniProtKB:P00639; propagated
                     from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=2380
     Region          20..282
                     /region_name="DNaseIc"
                     /note="deoxyribonuclease I; smart00476"
                     /db_xref="CDD:128752"
     mat_peptide     23..284
                     /product="Deoxyribonuclease-1. /id=PRO_0000007278"
                     /note="propagated from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=29666
     Site            order(29..30,32,36,61,63..65,97..98,100,133,156,159,190,
                     192,197,229,233..234,273..274)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,100,156,190,192,234,273..274)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,273)
                     /site_type="other"
                     /note="putative Mg binding site IVb [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(31,156,190,192,274)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197337"
     Site            31
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:197337"
     Site            order(32,36,63..65,97..98,100,133,156,159,190,192,197,233,
                     274)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197337"
     Site            35
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            40
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            87
                     /site_type="other"
                     /note="Nitration by tetranitromethane destroys a Ca(2+)
                     binding site and inactivates enzyme.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            89
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(121,134)
                     /site_type="other"
                     /note="Ca binding site II [ion binding]"
                     /db_xref="CDD:197337"
     Site            128
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(190,234,274)
                     /site_type="other"
                     /note="putative Mg binding site IVa [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(194,220)
                     /site_type="metal-binding"
                     /note="metal binding site III [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(223,225)
                     /site_type="other"
                     /note="Ca binding site I [ion binding]"
                     /db_xref="CDD:197337"
     CDS             1..284
                     /gene="Dnase1"
                     /gene_synonym="DNaseI; Dnl1"
                     /coded_by="NM_010061.6:294..1148"
                     /db_xref="CCDS:CCDS27913.1"
                     /db_xref="GeneID:13419"
                     /db_xref="MGI:MGI:103157"
ORIGIN      
        1 mrytglmgtl ltlvnllqla gtlriaafni rtfgetkmsn atlsvyfvki lsrydiaviq
       61 evrdshlvav gklldelnrd kpdtyryvvs eplgrksyke qylfvyrpdq vsildsyqyd
      121 dgcepcgndt fsrepaivkf fspytevqef aivplhaapt eavseidaly dvyldvwqkw
      181 gledimfmgd fnagcsyvts sqwssirlrt spifqwlipd sadttvtsth caydrivvag
      241 allqaavvpn savpfdfqae yglsnqlaea isdhypvevt lrki
//
LOCUS       NP_084046                945 aa            linear   ROD 27-AUG-2025
DEFINITION  netrin receptor UNC5B isoform 1 precursor [Mus musculus].
ACCESSION   NP_084046
VERSION     NP_084046.2
DBSOURCE    REFSEQ: accession NM_029770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 945)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 945)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 945)
  AUTHORS   Zhao,R., Ren,B., Xiao,Y., Tian,J., Zou,Y., Wei,J., Qi,Y., Hu,A.,
            Xie,X., Huang,Z.J., Shu,Y., He,M., Lu,J. and Tai,Y.
  TITLE     Axo-axonic synaptic input drives homeostatic plasticity by tuning
            the axon initial segment structurally and functionally
  JOURNAL   Sci Adv 10 (31), eadk4331 (2024)
   PUBMED   39093969
REFERENCE   4  (residues 1 to 945)
  AUTHORS   Raudales,R., Kim,G., Kelly,S.M., Hatfield,J., Guan,W., Zhao,S.,
            Paul,A., Qian,Y., Li,B. and Huang,Z.J.
  TITLE     Specific and comprehensive genetic targeting reveals brain-wide
            distribution and synaptic input patterns of GABAergic axo-axonic
            interneurons
  JOURNAL   Elife 13, 93481 (2024)
   PUBMED   39012795
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 945)
  AUTHORS   Raza,Q., Nadeem,T., Youn,S.W., Swaminathan,B., Gupta,A., Sargis,T.,
            Du,J., Cuervo,H., Eichmann,A., Ackerman,S.L., Naiche,L.A. and
            Kitajewski,J.
  TITLE     Notch signaling regulates UNC5B to suppress endothelial
            proliferation, migration, junction activity, and retinal plexus
            branching
  JOURNAL   Sci Rep 14 (1), 13603 (2024)
   PUBMED   38866944
  REMARK    GeneRIF: Notch signaling regulates UNC5B to suppress endothelial
            proliferation, migration, junction activity, and retinal plexus
            branching.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 945)
  AUTHORS   Alcantara,S., Ruiz,M., De Castro,F., Soriano,E. and Sotelo,C.
  TITLE     Netrin 1 acts as an attractive or as a repulsive cue for distinct
            migrating neurons during the development of the cerebellar system
  JOURNAL   Development 127 (7), 1359-1372 (2000)
   PUBMED   10704383
REFERENCE   7  (residues 1 to 945)
  AUTHORS   Bloch-Gallego,E., Ezan,F., Tessier-Lavigne,M. and Sotelo,C.
  TITLE     Floor plate and netrin-1 are involved in the migration and survival
            of inferior olivary neurons
  JOURNAL   J Neurosci 19 (11), 4407-4420 (1999)
   PUBMED   10341242
REFERENCE   8  (residues 1 to 945)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 945)
  AUTHORS   Leonardo,E.D., Hinck,L., Masu,M., Keino-Masu,K., Ackerman,S.L. and
            Tessier-Lavigne,M.
  TITLE     Vertebrate homologues of C. elegans UNC-5 are candidate netrin
            receptors
  JOURNAL   Nature 386 (6627), 833-838 (1997)
   PUBMED   9126742
REFERENCE   10 (residues 1 to 945)
  AUTHORS   Doherty,T.M., Kastelein,R., Menon,S., Andrade,S. and Coffman,R.L.
  TITLE     Modulation of murine macrophage function by IL-13
  JOURNAL   J Immunol 151 (12), 7151-7160 (1993)
   PUBMED   7903102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018177.1, AK158284.1, BC048162.1, AK147603.1 and AW488068.1.
            
            On Jan 28, 2006 this sequence version replaced NP_084046.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154271.1, AK154287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 31.52 cM"
     Protein         1..945
                     /product="netrin receptor UNC5B isoform 1 precursor"
                     /note="netrin receptor UNC5B; protein unc-5 homolog B;
                     protein unc-5 homolog 2; unc5 homolog 2"
                     /calculated_mol_wt=100946
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2811
     mat_peptide     27..945
                     /product="Netrin receptor UNC5B. /id=PRO_0000036072"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
                     /calculated_mol_wt=100946
     Region          157..243
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          170..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          184..188
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            222
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          236..239
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          249..300
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          305..353
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Site            347
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Site            378..398
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Site            412..413
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-3.
                     /evidence=ECO:0000250|UniProtKB:O08722; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          541..644
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     Site            581
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:O08747; propagated from
                     UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          689..838
                     /region_name="UPA domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          691..830
                     /region_name="UPA"
                     /note="UPA domain; pfam17217"
                     /db_xref="CDD:465384"
     Region          707..725
                     /region_name="Interaction with DCC.
                     /evidence=ECO:0000250|UniProtKB:O08722"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K1S3.1)"
     Region          858..941
                     /region_name="Death_UNC5B"
                     /note="Death domain found in Uncoordinated-5B; cd08802"
                     /db_xref="CDD:176780"
     Site            order(891..892,894..895,905,908..909,912..913)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:176780"
     CDS             1..945
                     /gene="Unc5b"
                     /gene_synonym="6330415E02Rik; A630020F16; D10Bwg0792e;
                     Unc5h2"
                     /coded_by="NM_029770.3:417..3254"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS23872.1"
                     /db_xref="GeneID:107449"
                     /db_xref="MGI:MGI:894703"
ORIGIN      
        1 mrarsgvrsa lllalllcwd ptpslagvds agqvlpdsyp sapaeqlpyf llepqdayiv
       61 knkpvelhcr afpatqiyfk cngewvsqnd hvtqesldea tglrvrevqi evsrqqveel
      121 fgledywcqc vawsssgttk srrayiriay lrknfdqepl akevpldhev llqcrppegv
      181 pvaevewlkn edvidpaqdt nflltidhnl iirqarlsdt anytcvakni vakrrsttat
      241 vivyvnggws swaewspcsn rcgrgwqkrt rtctnpapln ggafcegqaf qktacttvcp
      301 vdgawtewsk wsacstecah wrsrecmapp pqnggrdcsg tlldsknctd glcvlnqrtl
      361 ndpkshplet sgdvalyagl vvavfvvvav lmavgvivyr rncrdfdtdi tdssaaltgg
      421 fhpvnfktar pnnpqllhps appdltasag iyrgpvyalq dsadkipmtn splldplpsl
      481 kikvynssti gsgsgladga dllgvlppgt ypgdfsrdth flhlrsaslg sqhllglprd
      541 psssvsgtfg clggrlslpg tgvsllvpng aipqgkfydl ylhinkaest lplsegsqtv
      601 lspsvtcgpt glllcrpvvl tvphcaevia gdwifqlktq ahqghweevv tldeetlntp
      661 cycqleaksc hilldqlgty vfmgesysrs avkrlqlaif apalctsley slrvycledt
      721 pvalkevlel ertlggylve epkpllfkds yhnlrlslhd iphahwrskl lakyqeipfy
      781 hvwngsqral hctftlerhs lasteftckv cvrqvegegq ifqlhttlae tpagsldalc
      841 sapgnaittq lgpyafkipl sirqkicssl dapnsrgndw rllaqklsmd rylnyfatka
      901 sptgvildlw earqqddgdl nslasaleem gksemlvama tdgdc
//
LOCUS       NP_001408097             369 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform u [Mus musculus].
ACCESSION   NP_001408097 XP_030109114
VERSION     NP_001408097.1
DBSOURCE    REFSEQ: accession NM_001421168.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 369)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 369)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 369)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 369)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 369)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 369)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 369)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 369)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109114.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3748996.1,
                                           SRR17784651.1254859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..369
                     /product="ELAV-like protein 4 isoform u"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40627
     Region          46..368
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..369
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421168.1:117..1226"
                     /note="isoform u is encoded by transcript variant 24"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mrlqnqiist mepqvsngpt sntsngpssn nrncpspmqt gaatddsktn livnylpqnm
       61 tqeefrslfg sigeiesckl vrdkitgqsl gygfvnyidp kdaekaintl nglrlqtkti
      121 kvsyarpssa sirdanlyvs glpktmtqke leqlfsqygr iitsrilvdq vtgvsrgvgf
      181 irfdkrieae eaikglngqk psgatepitv kfannpsqks sqallsqlyq spnrrypgpl
      241 hhqaqrfrld nllnmaygvk rfspitidgm tslvgmnipg htgtgwcifv ynlspdsdes
      301 vlwqlfgpfg avnnvkvird fntnkckgfg fvtmtnydea amaiaslngy rlgdrvlqvs
      361 fktnkahks
//
LOCUS       NP_081702                343 aa            linear   ROD 27-AUG-2025
DEFINITION  draxin precursor [Mus musculus].
ACCESSION   NP_081702 XP_131857
VERSION     NP_081702.2
DBSOURCE    REFSEQ: accession NM_027426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 343)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 343)
  AUTHORS   Maeda,K., Tanimura,M., Masago,Y., Horiyama,T., Takemoto,H.,
            Sasaki,T., Koyama,R., Ikegaya,Y. and Ogawa,K.
  TITLE     Development of an in vitro compound screening system that replicate
            the in vivo spine phenotype of idiopathic ASD model mice
  JOURNAL   Front Pharmacol 15, 1455812 (2024)
   PUBMED   39286633
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 343)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 343)
  AUTHORS   Morcom,L., Edwards,T.J., Rider,E., Jones-Davis,D., Lim,J.W.,
            Chen,K.S., Dean,R.J., Bunt,J., Ye,Y., Gobius,I., Suarez,R.,
            Mandelstam,S., Sherr,E.H. and Richards,L.J.
  TITLE     DRAXIN regulates interhemispheric fissure remodelling to influence
            the extent of corpus callosum formation
  JOURNAL   Elife 10, e61618 (2021)
   PUBMED   33945466
  REMARK    GeneRIF: DRAXIN regulates interhemispheric fissure remodelling to
            influence the extent of corpus callosum formation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 343)
  AUTHORS   Tawarayama,H., Yamada,H., Amin,R., Morita-Fujimura,Y., Cooper,H.M.,
            Shinmyo,Y., Tanaka,H. and Ikawa,S.
  TITLE     Draxin-mediated Regulation of Granule Cell Progenitor
            Differentiation in the Postnatal Hippocampal Dentate Gyrus
  JOURNAL   Neuroscience 431, 184-192 (2020)
   PUBMED   32081722
REFERENCE   6  (residues 1 to 343)
  AUTHORS   Ahmed,G., Shinmyo,Y., Naser,I.B., Hossain,M., Song,X. and Tanaka,H.
  TITLE     Olfactory bulb axonal outgrowth is inhibited by draxin
  JOURNAL   Biochem Biophys Res Commun 398 (4), 730-734 (2010)
   PUBMED   20621059
  REMARK    GeneRIF: These results suggest that draxin functions as an
            inhibitory guidance cue for olfactory bulb axons and indicate its
            contribution to the formation of the lateral olfactory tract.
REFERENCE   7  (residues 1 to 343)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (residues 1 to 343)
  AUTHORS   Zhang,S., Su,Y., Shinmyo,Y., Islam,S.M., Naser,I.B., Ahmed,G.,
            Tamamaki,N. and Tanaka,H.
  TITLE     Draxin, a repulsive axon guidance protein, is involved in
            hippocampal development
  JOURNAL   Neurosci Res 66 (1), 53-61 (2010)
   PUBMED   19808066
  REMARK    GeneRIF: This study found that draxin, a repulsive axon guidance
            cue, was widely expressed in the developing hippocampus and draxin
            deficient mice possessed a smaller hippocampus.
REFERENCE   9  (residues 1 to 343)
  AUTHORS   Miyake,A., Takahashi,Y., Miwa,H., Shimada,A., Konishi,M. and
            Itoh,N.
  TITLE     Neucrin is a novel neural-specific secreted antagonist to canonical
            Wnt signaling
  JOURNAL   Biochem Biophys Res Commun 390 (3), 1051-1055 (2009)
   PUBMED   19857465
  REMARK    GeneRIF: Neucrin is a unique secreted Wnt antagonist that is
            predominantly expressed in developing neural tissues.
REFERENCE   10 (residues 1 to 343)
  AUTHORS   Islam,S.M., Shinmyo,Y., Okafuji,T., Su,Y., Naser,I.B., Ahmed,G.,
            Zhang,S., Chen,S., Ohta,K., Kiyonari,H., Abe,T., Tanaka,S.,
            Nishinakamura,R., Terashima,T., Kitamura,T. and Tanaka,H.
  TITLE     Draxin, a repulsive guidance protein for spinal cord and forebrain
            commissures
  JOURNAL   Science 323 (5912), 388-393 (2009)
   PUBMED   19150847
  REMARK    GeneRIF: draxin knockout mice showed defasciculation of spinal cord
            commissural axons & absence of all forebrain commissures; draxin is
            a previously unknown chemorepulsive axon guidance molecule required
            for the development of spinal cord & forebrain commissures
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY728334.1, BC060239.1 and BC058734.1.
            
            On Apr 22, 2009 this sequence version replaced NP_081702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060239.1, AK086198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.67 cM"
     Protein         1..343
                     /product="draxin precursor"
                     /note="dorsal repulsive axon guidance protein"
                     /calculated_mol_wt=35615
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2765
     mat_peptide     26..343
                     /product="Draxin. /id=PRO_0000273244"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PAL1.2)"
                     /calculated_mol_wt=35615
     Region          38..343
                     /region_name="Draxin"
                     /note="pfam15550"
                     /db_xref="CDD:464760"
     Region          52..79
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PAL1.2)"
     Site            258
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03060; propagated from
                     UniProtKB/Swiss-Prot (Q6PAL1.2)"
     CDS             1..343
                     /gene="Draxin"
                     /gene_synonym="2610109H07Rik; neucrin"
                     /coded_by="NM_027426.3:136..1167"
                     /db_xref="CCDS:CCDS18931.1"
                     /db_xref="GeneID:70433"
                     /db_xref="MGI:MGI:1917683"
ORIGIN      
        1 magcpvlrvp tlflilllfp elhtagtlas gssarnlpet hshlpssalw vsqashhgrr
       61 glgkkdrgpg rpsraqegav vtatkqasqm tlgqppagll qnkelllglt lpypekears
      121 pawervkkrg rehkrrrdrl rlhrgraair gpsslmkkve psedrmlegt meesstslap
      181 tmffltmtdg atptteesri lpvtslrpqt qprsdgevmp tldmalfdwt dyedlkpevw
      241 psakkkekhw shftsdgnet spaegdpcdh hqdclpgtcc dlrehlctph nrglnnkcfd
      301 dcmcmeglrc yakfhrnrrv trrkgrcvep etangdqgsf ini
//
LOCUS       NP_001277746             301 aa            linear   ROD 27-AUG-2025
DEFINITION  SPARC isoform 2 precursor [Mus musculus].
ACCESSION   NP_001277746 XP_006532730
VERSION     NP_001277746.1
DBSOURCE    REFSEQ: accession NM_001290817.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 301)
  AUTHORS   Cain,J.W., Erikson,D.W., Seo,H., Ross,A., Burghardt,R.C.,
            Bazer,F.W. and Johnson,G.A.
  TITLE     SPARC expression in the mouse decidua, placenta, and fetus:
            correlations with SPP1 expression
  JOURNAL   Placenta 168, 125-134 (2025)
   PUBMED   40544540
REFERENCE   2  (residues 1 to 301)
  AUTHORS   Li,C., Zhang,M., Du,Y., Liu,S., Li,D., Zhang,S., Ji,F., Zhang,J.
            and Jiao,J.
  TITLE     Compromised cell competition exhausts neural stem cells pool
  JOURNAL   Cell Prolif 57 (12), e13710 (2024)
   PUBMED   39010274
REFERENCE   3  (residues 1 to 301)
  AUTHORS   Xiao,G., Wei,Y., Xie,R., Tsang,Y., Gu,J., Shen,D., Ding,M.,
            Yuan,J., Xu,D. and Fei,J.
  TITLE     Citric acid promotes SPARC release in pancreatic cancer cells and
            inhibits the progression of pancreatic tumors in mice on a high-fat
            diet
  JOURNAL   FEBS J 291 (8), 1699-1718 (2024)
   PUBMED   38245817
  REMARK    GeneRIF: Citric acid promotes SPARC release in pancreatic cancer
            cells and inhibits the progression of pancreatic tumors in mice on
            a high-fat diet.
REFERENCE   4  (residues 1 to 301)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 301)
  AUTHORS   Arai,M., Kaku,M., Thant,L., Kitami,M., Ono,Y., Dobashi,A.,
            Iwama,H., Mizukoshi,M., Kitami,K., Matsumoto,M., Saito,I. and
            Uoshima,K.
  TITLE     Effect of Sparc knockout on the extracellular matrix of mouse
            periodontal ligament cells
  JOURNAL   Biochem Biophys Res Commun 692, 149364 (2024)
   PUBMED   38070276
  REMARK    GeneRIF: Effect of Sparc knockout on the extracellular matrix of
            mouse periodontal ligament cells.
REFERENCE   6  (residues 1 to 301)
  AUTHORS   Baron,B., Poirier,C., Simon-Chazottes,D., Barnier,C. and
            Guenet,J.L.
  TITLE     A new strategy useful for rapid identification of microsatellites
            from DNA libraries with large size inserts
  JOURNAL   Nucleic Acids Res 20 (14), 3665-3669 (1992)
   PUBMED   1386425
REFERENCE   7  (residues 1 to 301)
  AUTHORS   Bloom,M.L., Lee,B.K., Birkenmeier,C.S., Ma,Y., Zimmer,W.E.,
            Goodman,S.R., Eicher,E.M. and Barker,J.E.
  TITLE     Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 3 (5), 293-295 (1992)
   PUBMED   1638088
REFERENCE   8  (residues 1 to 301)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 301)
  AUTHORS   Baldacci,P.A., Richoux,V., Renard,J.P., Guenet,J.L. and Babinet,C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   10 (residues 1 to 301)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781653.1, BB857564.1, AK148670.1, AK161229.1, AA798908.1,
            CJ132527.1 and BE655213.1.
            
            On Mar 20, 2014 this sequence version replaced XP_006532730.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.62997.1, AK148670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.04 cM"
     Protein         1..301
                     /product="SPARC isoform 2 precursor"
                     /note="basement-membrane protein 40; secreted protein
                     acidic and rich in cysteine; osteonectin"
                     /calculated_mol_wt=32388
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1952
     Region          69..150
                     /region_name="FSL_SPARC"
                     /note="Follistatin-like SPARC (secreted protein, acidic,
                     and rich in cysteines) domain; SPARC/BM-40/osteonectin is
                     a multifunctional glycoprotein which modulates cellular
                     interaction with the extracellular matrix by its binding
                     to structural matrix proteins...; cd01328"
                     /db_xref="CDD:238649"
     Site            114
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238649"
     Site            114
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:3427055; propagated from
                     UniProtKB/Swiss-Prot (P07214.1)"
     Region          153..292
                     /region_name="EFh_SPARC_SPARC"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in secreted protein acidic and rich in cysteine
                     (SPARC); cd16235"
                     /db_xref="CDD:320014"
     Site            order(160..161,164..165,167..168,171..172,175,179,257,
                     260..261)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320014"
     Region          225..258
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     Site            order(237,242,249,272,274,276,283)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320014"
     Site            order(247..248,262)
                     /site_type="other"
                     /note="EC/FS-domain interface"
                     /db_xref="CDD:320014"
     Region          260..292
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     CDS             1..301
                     /gene="Sparc"
                     /gene_synonym="BM-40; ON"
                     /coded_by="NM_001290817.1:307..1212"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS70189.1"
                     /db_xref="GeneID:20692"
                     /db_xref="MGI:MGI:98373"
ORIGIN      
        1 mrawiffllc lagralaapq tevaeeivee etvveetgvp vganpvqvem gefedgaeet
       61 veevvadnpc qnhhckhgkv celdesntpm cvcqdptscp apigefekvc sndnktfdss
      121 chffatkctl egtkkghklh ldyigpckyi apcldselte fplrmrdwlk nvlvtlyerd
      181 egnnlltekq klrvkkihen ekrleagdhp vellardfek nynmyifpvh wqfgqldqhp
      241 idgylshtel aplraplipm ehcttrffet cdldndkyia leewagcfgi keqdinkdlv
      301 i
//
LOCUS       NP_001230092             679 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor SOX-5 isoform c [Mus musculus].
ACCESSION   NP_001230092
VERSION     NP_001230092.1
DBSOURCE    REFSEQ: accession NM_001243163.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 679)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 679)
  AUTHORS   Medina-Menendez,C., Tirado-Melendro,P., Li,L., Rodriguez-Martin,P.,
            Melgarejo-de la Pena,E., Diaz-Garcia,M., Valdes-Bescos,M.,
            Lopez-Sansegundo,R. and Morales,A.V.
  TITLE     Sox5 controls the establishment of quiescence in neural stem cells
            during postnatal development
  JOURNAL   PLoS Biol 23 (7), e3002654 (2025)
   PUBMED   40720543
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 679)
  AUTHORS   Liu,G., Wu,C., Yin,L., Hou,L., Yin,B., Qiang,B., Shu,P. and Peng,X.
  TITLE     MiR-125/let-7 cluster orchestrates neuronal cell fate determination
            and cortical layer formation during neurogenesis
  JOURNAL   Biochem Biophys Res Commun 766, 151815 (2025)
   PUBMED   40300336
REFERENCE   4  (residues 1 to 679)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 679)
  AUTHORS   Wu,J., Yu,H., Dou,X., Yin,B., Hou,L., Xue,Y., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     Posttranscriptional Control of Neural Progenitors Temporal Dynamics
            During Neocortical Development by Syncrip
  JOURNAL   Adv Sci (Weinh) 12 (8), e2411732 (2025)
   PUBMED   39776340
REFERENCE   6  (residues 1 to 679)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   7  (residues 1 to 679)
  AUTHORS   Connor,F., Cary,P.D., Read,C.M., Preston,N.S., Driscoll,P.C.,
            Denny,P., Crane-Robinson,C. and Ashworth,A.
  TITLE     DNA binding and bending properties of the post-meiotically
            expressed Sry-related protein Sox-5
  JOURNAL   Nucleic Acids Res 22 (16), 3339-3346 (1994)
   PUBMED   8078769
REFERENCE   8  (residues 1 to 679)
  AUTHORS   Wright,E.M., Snopek,B. and Koopman,P.
  TITLE     Seven new members of the Sox gene family expressed during mouse
            development
  JOURNAL   Nucleic Acids Res 21 (3), 744 (1993)
   PUBMED   8441686
REFERENCE   9  (residues 1 to 679)
  AUTHORS   Denny,P., Swift,S., Connor,F. and Ashworth,A.
  TITLE     An SRY-related gene expressed during spermatogenesis in the mouse
            encodes a sequence-specific DNA-binding protein
  JOURNAL   EMBO J 11 (10), 3705-3712 (1992)
   PUBMED   1396566
REFERENCE   10 (residues 1 to 679)
  AUTHORS   Denny,P., Swift,S., Brand,N., Dabhade,N., Barton,P. and Ashworth,A.
  TITLE     A conserved family of genes related to the testis determining gene,
            SRY
  JOURNAL   Nucleic Acids Res 20 (11), 2887 (1992)
   PUBMED   1614875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161059.4, BC110478.2, AK081802.1 and AC167021.3.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5_ coding region and lacks an in-frame exon in
            the 3_ coding region, compared to variant 1. This results in a
            shorter protein (isoform c), compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010604.1, SRR1660815.70211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 76.14 cM"
     Protein         1..679
                     /product="transcription factor SOX-5 isoform c"
                     /note="transcription factor SOX-5; SRY-box containing gene
                     5"
                     /calculated_mol_wt=75078
     Region          470..547
                     /region_name="HMG-box_EGL13-like"
                     /note="high mobility group (HMG)-box found in
                     Caenorhabditis elegans protein egg laying defective 13
                     (EGL-13) and similar proteins; cd22042"
                     /db_xref="CDD:438848"
     Site            order(471,473..474,476..477,479..480,484,487,491,498..500,
                     503..504,507,510..511,529,539,541..544)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438848"
     CDS             1..679
                     /gene="Sox5"
                     /gene_synonym="A730017D01Rik"
                     /coded_by="NM_001243163.1:201..2240"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS57469.1"
                     /db_xref="GeneID:20678"
                     /db_xref="MGI:MGI:98367"
ORIGIN      
        1 mltdpdlpqe fermsskrpa spygetdgev amvtsrqkve eeeserlpaf hlplhevdgn
       61 kvmsslapyn sstspqkaee ggrqsgesvs saalgtperr kgsladvvdt lkqrkmeeli
      121 knepedtpsi ekllskdwkd kllamgsgnf geikgtpesl aekerqlmgm inqltslreq
      181 llaahdeqkk laasqiekqr qqmelakqqq eqiarqqqql lqqqhkinll qqqiqvqgql
      241 pplmipvfpp dqrtlaaaaq qgfllppgfs ykagcsdpyp vqlipttmaa aaaatpglgp
      301 lqlqdevaqp lnlsakpkts dgkspaspts phmpalrins gagplkasvp aalaspsarv
      361 stigylndhd avtkaiqear qmkeqlrreq qaldgkvavv nsiglsncrt ekekttlesl
      421 tqqlavkqne egkfshgmmd fnmsgdsdgs agvsesriyr esrgrgsnep hikrpmnafm
      481 vwakderrki lqafpdmhns niskilgsrw kamtnlekqp yyeeqarlsk qhlekypdyk
      541 ykprpkrtcl vdgkklrige ykaimrnrrq emrqyfnvgq qaqipiatag vvypsaiama
      601 gmpsphlpse hssvssspep gmpviqstyg akgeephike eiqaedinge iyeeydeeee
      661 dpdvdygsds enhiagqan
//
LOCUS       NP_001348141             792 aa            linear   ROD 27-AUG-2025
DEFINITION  glucocorticoid receptor [Mus musculus].
ACCESSION   NP_001348141 XP_017173326
VERSION     NP_001348141.1
DBSOURCE    REFSEQ: accession NM_001361212.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 792)
  AUTHORS   Zhu,W., Vanderhaeghen,T., Timmermans,S., Vandewalle,J.,
            Eggermont,M., Verhoog,N.J.D. and Libert,C.
  TITLE     Modulation of glucocorticoid receptor function under iron overload
  JOURNAL   Front Immunol 16, 1605420 (2025)
   PUBMED   40607412
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 792)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   3  (residues 1 to 792)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   4  (residues 1 to 792)
  AUTHORS   Cavalcanti de Albuquerque,J.P., Hunter,J., Domingues,R.G.,
            Harno,E., Worth,A.A., Liguori,F.M., D'Alessio,A., Aviello,G.,
            Bechtold,D., White,A., Luckman,S.M., Hepworth,M.R. and
            D'Agostino,G.
  TITLE     Brain sensing of metabolic state regulates circulating monocytes
  JOURNAL   Sci Immunol 10 (106), eadr3226 (2025)
   PUBMED   40184437
REFERENCE   5  (residues 1 to 792)
  AUTHORS   Diba,F., Watson,C.S. and Gametchu,B.
  TITLE     5'UTR sequences of the glucocorticoid receptor 1A transcript encode
            a peptide associated with translational regulation of the
            glucocorticoid receptor
  JOURNAL   J Cell Biochem 81 (1), 149-161 (2001)
   PUBMED   11180405
REFERENCE   6  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Association of the glucocorticoid receptor alternatively-spliced
            transcript 1A with the presence of the high molecular weight
            membrane glucocorticoid receptor in mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 430-446 (1999)
   PUBMED   10412044
REFERENCE   7  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Multiple glucocorticoid receptor transcripts in membrane
            glucocorticoid receptor-enriched S-49 mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 418-429 (1999)
   PUBMED   10412043
REFERENCE   8  (residues 1 to 792)
  AUTHORS   Strahle,U., Schmidt,A., Kelsey,G., Stewart,A.F., Cole,T.J.,
            Schmid,W. and Schutz,G.
  TITLE     At least three promoters direct expression of the mouse
            glucocorticoid receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6731-6735 (1992)
   PUBMED   1495961
REFERENCE   9  (residues 1 to 792)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   10 (residues 1 to 792)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124417.5 and AC007995.23.
            
            On Apr 27, 2018 this sequence version replaced XP_017173326.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.168808.1,
                                           SRR9219379.8040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 21.09 cM"
     Protein         1..792
                     /product="glucocorticoid receptor"
                     /note="glucocorticoid receptor 1; glucocorticoid receptor
                     subtype P"
                     /calculated_mol_wt=87033
     Region          1..436
                     /region_name="Modulating"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            24
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          27..418
                     /region_name="GCR"
                     /note="Glucocorticoid receptor; pfam02155"
                     /db_xref="CDD:426625"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          67..98
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          148..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            168
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            229
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            421
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          433..510
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(437,440,454,457,473,479,489,492)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(447..449,455..456,458..459,462..463,471,486..487,
                     493)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(472..474,476,479..480,484..485,488)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Site            496
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          501..792
                     /region_name="Interaction with CLOCK.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          503..538
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            508
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            510
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            511
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          546..792
                     /region_name="NR_LBD_GR"
                     /note="Ligand binding domain of the glucocorticoid
                     receptor, a member of the nuclear receptor superfamily;
                     cd07076"
                     /db_xref="CDD:132761"
     Region          547..712
                     /region_name="Interaction with CRY1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            order(560,562..566,629..630,640..641,643,645)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132761"
     Site            order(575,578..579,582,585..586,615..616,619..620,623,626,
                     638,657,661,747,750,752)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132761"
     Site            order(590,594,600,604..605,607..608,611..612,767,770..771,
                     773..774,778)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132761"
     CDS             1..792
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /coded_by="NM_001361212.1:273..2651"
                     /db_xref="CCDS:CCDS37791.1"
                     /db_xref="GeneID:14815"
                     /db_xref="MGI:MGI:95824"
ORIGIN      
        1 mdskeslapp grdevpssll grgrgsvmdl yktlrggatv kvsasspsva aasqadskqq
       61 rilldfskgs asnaqqqqqq qqqqqqqqqq qpqpdlskav slsmglymge tetkvmgndl
      121 gypqqgqlgl ssgetdfrll eesianlnrs tsrpenpkss tpaagcatpt ekefpqthsd
      181 psseqqnrks qpgtnggsvk lyttdqstfd ilqdlefsag spgketnesp wrsdlliden
      241 llsplagedd pfllegdvne dckplilpdt kpkiqdtgdt ilsspssval pqvktekddf
      301 ielctpgvik qeklgpvycq asfsgtniig nkmsaisvhg vstsggqmyh ydmntaslsq
      361 qqdqkpvfnv ippipvgsen wnrcqgsged nltslgamnf agrsvfsngy sspgmrpdvs
      421 sppsssstat gpppklclvc sdeasgchyg vltcgsckvf fkravegqhn ylcagrndci
      481 idkirrkncp acryrkclqa gmnlearktk kkikgiqqat agvsqdtsen anktivpaal
      541 pqltptlvsl leviepevly agydssvpds awrimttlnm lggrqviaav kwakaipgfr
      601 nlhlddqmtl lqyswmflma falgwrsyrq asgnllcfap dliineqrmt lpcmydqckh
      661 mlfistelqr lqvsyeeylc mktllllssv pkeglksqel fdeirmtyik elgkaivkre
      721 gnssqnwqrf yqltklldsm hdvvenllsy cfqtfldksm siefpemlae iitnqipkys
      781 ngnikkllfh qk
//
LOCUS       NP_001346827             306 aa            linear   ROD 27-AUG-2025
DEFINITION  T-lymphocyte activation antigen CD80 precursor [Mus musculus].
ACCESSION   NP_001346827 XP_017172346
VERSION     NP_001346827.1
DBSOURCE    REFSEQ: accession NM_001359898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 306)
  AUTHORS   Jaggi,U. and Ghiasi,H.
  TITLE     Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency
  JOURNAL   Viruses 16 (9), 1379 (2024)
   PUBMED   39339855
  REMARK    GeneRIF: Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 306)
  AUTHORS   Luan,J., Truong,C., Vuchkovska,A., Guo,W., Good,J., Liu,B.,
            Gang,A., Infarinato,N., Stewart,K., Polak,L., Pasolli,H.A.,
            Andretta,E., Rudensky,A.Y., Fuchs,E. and Miao,Y.
  TITLE     CD80 on skin stem cells promotes local expansion of regulatory T
            cells upon injury to orchestrate repair within an inflammatory
            environment
  JOURNAL   Immunity 57 (5), 1071-1086 (2024)
   PUBMED   38677291
  REMARK    GeneRIF: CD80 on skin stem cells promotes local expansion of
            regulatory T cells upon injury to orchestrate repair within an
            inflammatory environment.
REFERENCE   3  (residues 1 to 306)
  AUTHORS   Alugupalli,K.R.
  TITLE     Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity
            of Multivalent Meningococcal Polysaccharide Conjugate Vaccines
  JOURNAL   Immunohorizons 8 (4), 317-325 (2024)
   PUBMED   38625118
REFERENCE   4  (residues 1 to 306)
  AUTHORS   Jaggi,U., Matundan,H.H., Oh,J.J. and Ghiasi,H.
  TITLE     Absence of CD80 reduces HSV-1 replication in the eye and delays
            reactivation but not latency levels
  JOURNAL   J Virol 98 (3), e0201023 (2024)
   PUBMED   38376148
  REMARK    GeneRIF: Absence of CD80 reduces HSV-1 replication in the eye and
            delays reactivation but not latency levels.
REFERENCE   5  (residues 1 to 306)
  AUTHORS   Subileau,M. and Vittet,D.
  TITLE     Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 7 (2023)
   PUBMED   38054922
REFERENCE   6  (residues 1 to 306)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (residues 1 to 306)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
REFERENCE   8  (residues 1 to 306)
  AUTHORS   Larsen,C.P., Ritchie,S.C., Pearson,T.C., Linsley,P.S. and
            Lowry,R.P.
  TITLE     Functional expression of the costimulatory molecule, B7/BB1, on
            murine dendritic cell populations
  JOURNAL   J Exp Med 176 (4), 1215-1220 (1992)
   PUBMED   1328465
REFERENCE   9  (residues 1 to 306)
  AUTHORS   Razi-Wolf,Z., Freeman,G.J., Galvin,F., Benacerraf,B., Nadler,L. and
            Reiser,H.
  TITLE     Expression and function of the murine B7 antigen, the major
            costimulatory molecule expressed by peritoneal exudate cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4210-4214 (1992)
   PUBMED   1373896
REFERENCE   10 (residues 1 to 306)
  AUTHORS   Selvakumar,A., Mohanraj,B.K., Eddy,R.L., Shows,T.B., White,P.C. and
            Dupont,B.
  TITLE     Genomic organization and chromosomal location of the human gene
            encoding the B-lymphocyte activation antigen B7
  JOURNAL   Immunogenetics 36 (3), 175-181 (1992)
   PUBMED   1377173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC209577.2.
            
            On Jan 18, 2018 this sequence version replaced XP_017172346.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131959.1, AJ278965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.86 cM"
     Protein         1..306
                     /product="T-lymphocyte activation antigen CD80 precursor"
                     /note="B7 protein; activation B7-1 antigen"
                     /calculated_mol_wt=30387
     sig_peptide     1..37
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
                     /calculated_mol_wt=4221
     mat_peptide     38..306
                     /product="T-lymphocyte activation antigen CD80.
                     /id=PRO_0000014548"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
                     /calculated_mol_wt=30387
     Region          39..142
                     /region_name="IgV_CD80"
                     /note="Immunoglobulin variable domain (IgV) in Cluster of
                     Differentiation (CD) 80; cd16086"
                     /db_xref="CDD:319335"
     Region          39..54
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:319335"
     Region          40..45
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:319335"
     Region          49..55
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:319335"
     Region          55..64
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:319335"
     Site            order(60,63,80,85,96,98..100,105,107)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319335"
     Region          65..72
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:319335"
     Region          65..71
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:319335"
     Site            order(67,69,71,74,76,85,99,120,122,129..131)
                     /site_type="other"
                     /note="B7-1/CTLA-4 complex [polypeptide binding]"
                     /db_xref="CDD:319335"
     Region          72..91
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:319335"
     Region          76..81
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:319335"
     Region          84..87
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:319335"
     Region          92..124
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:319335"
     Site            93
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          94..100
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:319335"
     Site            99
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          102..107
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:319335"
     Region          115..125
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:319335"
     Region          125..128
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:319335"
     Region          128..142
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:319335"
     Region          129..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:319335"
     Region          145..235
                     /region_name="IgC1_CD80"
                     /note="Immunoglobulin constant (IgC)-like domain of
                     antigen receptor Cluster of Differentiation (CD) 80;
                     member of the C1-set of Ig superfamily (IgSF) domains;
                     cd16083"
                     /db_xref="CDD:409505"
     Region          148..154
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409505"
     Site            149
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          160..168
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409505"
     Site            order(171,197..200)
                     /site_type="other"
                     /note="intrachain IgC domain interface [polypeptide
                     binding]"
                     /db_xref="CDD:409505"
     Region          174..180
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409505"
     Region          182..184
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409505"
     Region          189..196
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409505"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          200..210
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409505"
     Site            210
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          214..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409505"
     Site            214
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          226..235
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409505"
     Region          227..246
                     /region_name="Ig-hinge-like. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
     Site            247..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
     CDS             1..306
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /coded_by="NM_001359898.1:249..1169"
                     /db_xref="CCDS:CCDS28168.1"
                     /db_xref="GeneID:12519"
                     /db_xref="MGI:MGI:101775"
ORIGIN      
        1 macncqlmqd tpllkfpcpr lillfvllir lsqvssdvde qlsksvkdkv llpcrynsph
       61 edesedriyw qkhdkvvlsv iagklkvwpe yknrtlydnt tysliilglv lsdrgtyscv
      121 vqkkergtye vkhlalvkls ikadfstpni tesgnpsadt kritcfasgg fpkprfswle
      181 ngrelpgint tisqdpesel ytissqldfn ttrnhtikcl ikygdahvse dftwekpped
      241 ppdskntlvl fgagfgavit vvvivviikc fckhrscfrr neasretnns ltfgpeeala
      301 eqtvfl
//
LOCUS       NP_001344467            1581 aa            linear   ROD 27-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 8 isoform 2 [Mus
            musculus].
ACCESSION   NP_001344467 XP_006540813
VERSION     NP_001344467.1
DBSOURCE    REFSEQ: accession NM_001357538.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1581)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (residues 1 to 1581)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1581)
  AUTHORS   Osipovich,A.B., Zhou,F.Y., Chong,J.J., Trinh,L.T., Cottam,M.A.,
            Shrestha,S., Cartailler,J.P. and Magnuson,M.A.
  TITLE     Deletion of Ascl1 in pancreatic beta-cells improves insulin
            secretion, promotes parasympathetic innervation, and attenuates
            dedifferentiation during metabolic stress
  JOURNAL   Mol Metab 78, 101811 (2023)
   PUBMED   37769990
REFERENCE   4  (residues 1 to 1581)
  AUTHORS   Peterson,S.M., Juliana,C.A., Hu,C.F., Chai,J., Holliday,C.,
            Chan,K.Y., Lujan Hernandez,A.G., Challocombe,Z., Wang,L., Han,Z.,
            Haas,N., Stafford,R., Axelrod,F., Yuan,T.Z., De Leon,D.D. and
            Sato,A.K.
  TITLE     Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist
            Antibody for Treatment of Hyperinsulinism
  JOURNAL   Diabetes 72 (9), 1320-1329 (2023)
   PUBMED   37358194
REFERENCE   5  (residues 1 to 1581)
  AUTHORS   Stokum,J.A., Shim,B., Negoita,S., Tsymbalyuk,N., Tsymbalyuk,O.,
            Ivanova,S., Keledjian,K., Bryan,J., Blaustein,M.P., Jha,R.M.,
            Kahle,K.T., Gerzanich,V. and Simard,J.M.
  TITLE     Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet
            induces water influx through AQP4 and brain swelling after ischemic
            stroke
  JOURNAL   Sci Signal 16 (788), eadd6364 (2023)
   PUBMED   37279286
REFERENCE   6  (residues 1 to 1581)
  AUTHORS   Hernandez-Sanchez,C., Wood,T.L. and LeRoith,D.
  TITLE     Developmental and tissue-specific sulfonylurea receptor gene
            expression
  JOURNAL   Endocrinology 138 (2), 705-711 (1997)
   PUBMED   9003005
REFERENCE   7  (residues 1 to 1581)
  AUTHORS   Isomoto,S., Kondo,C., Yamada,M., Matsumoto,S., Higashiguchi,O.,
            Horio,Y., Matsuzawa,Y. and Kurachi,Y.
  TITLE     A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth
            muscle type ATP-sensitive K+ channel
  JOURNAL   J Biol Chem 271 (40), 24321-24324 (1996)
   PUBMED   8798681
REFERENCE   8  (residues 1 to 1581)
  AUTHORS   Chung,W.K., Goldberg-Berman,J., Power-Kehoe,L. and Leibel,R.L.
  TITLE     Molecular mapping of the tubby (tub) mutation on mouse chromosome 7
  JOURNAL   Genomics 32 (2), 210-217 (1996)
   PUBMED   8833147
REFERENCE   9  (residues 1 to 1581)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   10 (residues 1 to 1581)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120135.7 and AC115036.10.
            
            On Nov 4, 2017 this sequence version replaced XP_006540813.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.233819.1,
                                           SRR1660813.95336.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.66 cM"
     Protein         1..1581
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 2"
                     /note="sulfonylurea receptor; ATP-binding cassette,
                     sub-family C (CFTR/MRP), member 8"
                     /calculated_mol_wt=177060
     Region          224..1578
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1581
                     /gene="Abcc8"
                     /gene_synonym="D930031B21Rik; Sur; SUR1"
                     /coded_by="NM_001357538.2:69..4814"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:20927"
                     /db_xref="MGI:MGI:1352629"
ORIGIN      
        1 mplafcgten hsaayrvdqg vlnngcfvda lnvvphvfll fitfpilfig wgsqsskvhi
       61 hhstwlhfpg hnlrwiltfm llfvlvceia egilsdgvte srhlhlympa gmafmaaits
      121 vvyyhniets nfpklliall iywtlafitk tikfvkfydh aigfsqlrfc ltgllvilyg
      181 mlllveinvi rvrryiffkt prevkppedl qdlgvrflqp fvnllskgty wwmnafikta
      241 hrkpidlrai gklpiamral tnyqrlcaaf daqarkdtqs qqgaraiwra lchafgrrlv
      301 lsstfrilad llgfagplci fgivdhlgke nhvfqpktqf lgvyfvssqe flgnayvlav
      361 llflalllqr tflqasyyva ietginlrga iqtkiynkim hlstsnlsmg emtagqicnl
      421 vaidtnqlmw ffflcpnlwa mpvqiivgvi llyyilgvsa ligaaviill apvqyfvatk
      481 lsqaqrstle ysnerlkqtn emlrgikllk lyawenifcs rvemtrrkem tslrafavyt
      541 sisifmntai piaavlitfv ghvsffkesd fspsvafasl slfhilvtpl fllssvvrst
      601 vkalvsvqkl seflssaeir eeqcaprepa pqgqagkyqa vplkvvnrkr pareevrdll
      661 gplqrltpsm dgdadnfcvq iiggfftwtp dgiptlsnit iriprgqltm ivgqvgcgks
      721 slllatlgem qrvsgavfwn slpdsegedp snperetaad sdarsrgpva yasqkpwlln
      781 atveenitfe spfnkqrykm vieacslqpd idilphgdqt qigerginls ggqrqrisva
      841 ralyqhtnvv flddpfsald vhlsdhlmqa gilellrddk rtvvlvthkl qylphadwii
      901 amkdgtiqre gtlkdfqrse cqlfehwktl mnrqdqelek etvmerkape psqglprams
      961 srdglllded eeeeeaaese eddnlssvlh qrakipwrac tkylssagvl llsllvfsql
     1021 lkhmvlvaid ywlakwtdsa lvlspaarnc slsqecaldq svyamvftvl cslgialclv
     1081 tsvtvewtgl kvakrlhrsl lnriilapmr ffettplgsi lnrfssdcnt idqhipstle
     1141 clsrstllcv saltvisyvt pvflvallpl avvcyfiqky frvasrdlqq lddttqlpll
     1201 shfaetvegl ttirafryea rfqqklleyt dsnniaslfl taanrwlevr meyigacvvl
     1261 iaaatsisns lhrelsaglv glgltyalmv snylnwmvrn ladmeiqlga vkrihtllkt
     1321 eaesyeglla pslipknwpd qgkiqiqnls vrydsslkpv lkhvnaliap gqkigicgrt
     1381 gsgkssfsla ffrmvdmfeg riiidgidia klplhtlrsr lsiilqdpvl fsgtirfnld
     1441 pekkcsdstl wealeiaqlk lvvkalpggl daiiteggen fsqgqrqlfc larafvrkts
     1501 ifimdeatas idmatenilq kvvmtafadr tvvtiahrvh tilsadlvmv lkrgailefd
     1561 kpekllsqkd svfasfvrad k
//
LOCUS       NP_032577                386 aa            linear   ROD 27-AUG-2025
DEFINITION  MAP kinase-activated protein kinase 2 [Mus musculus].
ACCESSION   NP_032577 XP_203771
VERSION     NP_032577.1
DBSOURCE    REFSEQ: accession NM_008551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 386)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 386)
  AUTHORS   Yadav,S., El Hamra,R., Alturki,N.A., Ariana,A., Bhan,A., Hurley,K.,
            Gaestel,M., Blackshear,P.J., Blais,A. and Sad,S.
  TITLE     Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of
            inflammatory cytokines during necroptosis stimulation
  JOURNAL   Cell Death Dis 15 (8), 574 (2024)
   PUBMED   39117638
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 386)
  AUTHORS   Chulkina,M., Rohmer,C., McAninch,S., Panganiban,R.P., Villeger,R.,
            Portolese,A., Ciocirlan,J., Yang,W., Cohen,C., Koltun,W.,
            Valentine,J.F., Cong,Y., Yochum,G., Beswick,E.J. and Pinchuk,I.V.
  TITLE     Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target
            for Inflammation-Associated Fibrosis in Crohn's Disease
  JOURNAL   J Crohns Colitis 18 (7), 1147-1161 (2024)
   PUBMED   38224550
  REMARK    GeneRIF: Increased Activity of MAPKAPK2 within Mesenchymal Cells as
            a Target for Inflammation-Associated Fibrosis in Crohn's Disease.
REFERENCE   4  (residues 1 to 386)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 386)
  AUTHORS   Jacenik,D., Lebish,E.J. and Beswick,E.J.
  TITLE     MK2 drives progression of pancreas and colon cancers by suppressing
            CD8+ T cell cytotoxic function and is a potential immunotherapy
            target
  JOURNAL   Front Immunol 14, 1212100 (2023)
   PUBMED   37415974
  REMARK    GeneRIF: MK2 drives progression of pancreas and colon cancers by
            suppressing CD8[+] T cell cytotoxic function and is a potential
            immunotherapy target.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 386)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (residues 1 to 386)
  AUTHORS   Kotlyarov,A., Neininger,A., Schubert,C., Eckert,R., Birchmeier,C.,
            Volk,H.D. and Gaestel,M.
  TITLE     MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
  JOURNAL   Nat Cell Biol 1 (2), 94-97 (1999)
   PUBMED   10559880
REFERENCE   8  (residues 1 to 386)
  AUTHORS   Engel,K., Kotlyarov,A. and Gaestel,M.
  TITLE     Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is
            regulated by phosphorylation
  JOURNAL   EMBO J 17 (12), 3363-3371 (1998)
   PUBMED   9628873
REFERENCE   9  (residues 1 to 386)
  AUTHORS   Plath,K., Engel,K., Schwedersky,G. and Gaestel,M.
  TITLE     Characterization of the proline-rich region of mouse MAPKAP kinase
            2: influence on catalytic properties and binding to the c-abl SH3
            domain in vitro
  JOURNAL   Biochem Biophys Res Commun 203 (2), 1188-1194 (1994)
   PUBMED   8093038
REFERENCE   10 (residues 1 to 386)
  AUTHORS   Engel,K., Plath,K. and Gaestel,M.
  TITLE     The MAP kinase-activated protein kinase 2 contains a proline-rich
            SH3-binding domain
  JOURNAL   FEBS Lett 336 (1), 143-147 (1993)
   PUBMED   8262198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513351.26, CB249442.1, BC063064.1 and BE979119.1.
            
            On Mar 22, 2004 this sequence version replaced XP_203771.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063064.1, SRR7345562.694856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     Protein         1..386
                     /product="MAP kinase-activated protein kinase 2"
                     /EC_number="2.7.11.1"
                     /note="MAPK-activated protein kinase 2; MAPKAP kinase 2"
                     /calculated_mol_wt=43919
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Region          47..349
                     /region_name="STKc_MAPKAPK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Mitogen-activated protein kinase-activated protein kinase
                     2; cd14170"
                     /db_xref="CDD:271072"
     Site            order(56..61,64,77,79,104,124..127,131,133,171..172,174,
                     176..177,179,192..193,196,210..214,216)
                     /site_type="active"
                     /db_xref="CDD:271072"
     Site            order(56..61,64,77,79,104,124..127,177,179,192..193)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271072"
     Site            order(58..61,63,213..217,221,223,226,247,249..252,
                     266..267,269..270,294..295,333..334,336..338,340..341,
                     343..345,347..348)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271072"
     Site            order(60,131,133,171..172,174,176,196,210..214,216)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271072"
     Site            192..214
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271072"
     Site            208
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:7592979,
                     ECO:0000269|PubMed:9628873; propagated from
                     UniProtKB/Swiss-Prot (P49138.2)"
     Site            258
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:P49137; propagated from
                     UniProtKB/Swiss-Prot (P49138.2)"
     Region          314..350
                     /region_name="Autoinhibitory helix"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P49138.2)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:7592979,
                     ECO:0000269|PubMed:9628873; propagated from
                     UniProtKB/Swiss-Prot (P49138.2)"
     Region          331..354
                     /region_name="Nuclear export signal (NES)"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Region          342..351
                     /region_name="Nuclear export signal (NES).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Region          352..376
                     /region_name="p38 MAPK-binding site.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Region          357..360
                     /region_name="Bipartite nuclear localization signal 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     Region          371..375
                     /region_name="Bipartite nuclear localization signal 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P49138.2)"
     CDS             1..386
                     /gene="Mapkapk2"
                     /gene_synonym="MAPKAP-K2; MK-2; MK2; Rps6kc1"
                     /coded_by="NM_008551.2:319..1479"
                     /db_xref="CCDS:CCDS15266.1"
                     /db_xref="GeneID:17164"
                     /db_xref="MGI:MGI:109298"
ORIGIN      
        1 mlsgspgqtp papfpspppp apaqppppfp qfhvksglqi rknaitddyk vtsqvlglgi
       61 ngkvlrifdk rtqqkfalkm lqdcpkarre velhwrasqc phivhivdvy enlyagrkcl
      121 livmecldgg elfsriqdrg dqaftereas eimksigeai qylhsiniah rdvkpenlly
      181 tskrpnailk ltdfgfaket tshnslttpc ytpyyvapev lgpekydksc dmwslgvimy
      241 illcgyppfy snhglaispg mktrirmgqy efpnpewsev seevkmlirn llkteptqrm
      301 titefmnhpw imqstkvpqt plhtsrvlke dkerwedvke emtsalatmr vdyeqikikk
      361 iedasnplll krrkkarave daalah
//
LOCUS       NP_001342183             206 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform a [Mus musculus].
ACCESSION   NP_001342183 XP_017172247
VERSION     NP_001342183.1
DBSOURCE    REFSEQ: accession NM_001355254.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            On Sep 20, 2017 this sequence version replaced XP_017172247.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.1975.1,
                                           SRR7974084.18554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..206
                     /product="synaptosomal-associated protein 25 isoform a"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=23184
     Region          1..75
                     /region_name="Interaction with CENPF.
                     /evidence=ECO:0000269|PubMed:16672379"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..142
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          111..120
                     /region_name="Interaction with ZDHHC17.
                     /evidence=ECO:0000250|UniProtKB:P60880"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC and PKA.
                     /evidence=ECO:0000269|PubMed:12459461,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Region          143..201
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(143,145..146,149..154,156..157,160..161,163..165,
                     167..168,171..172,174..175,177..182,184..185,188,191,195,
                     198,201)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            174
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     Site            180..181
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type E (BoNT/E).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:12459461; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            197..198
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type A (BoNT/A, botA).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     CDS             1..206
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001355254.1:161..781"
                     /note="isoform a is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS16793.1"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqleri
       61 eegmdqinkd mkeaeknltd lgkfcglcvc pcnklkssda ykkawgnnqd gvvasqparv
      121 vdereqmais ggfirrvtnd arenemdenl eqvsgiignl rhmaldmgne idtqnrqidr
      181 imekadsnkt rideanqrat kmlgsg
//
LOCUS       NP_001273987             146 aa            linear   ROD 27-AUG-2025
DEFINITION  vascular endothelial growth factor A, long form isoform 9 precursor
            [Mus musculus].
ACCESSION   NP_001273987
VERSION     NP_001273987.1
DBSOURCE    REFSEQ: accession NM_001287058.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Man,X., Usui,N., Doi,M. and Shimada,S.
  TITLE     Sex differences in placental structure and gene expression in ICR
            mice during embryonic development
  JOURNAL   Sci Rep 15 (1), 24067 (2025)
   PUBMED   40617958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Bastide,A., Karaa,Z., Bornes,S., Hieblot,C., Lacazette,E., Prats,H.
            and Touriol,C.
  TITLE     An upstream open reading frame within an IRES controls expression
            of a specific VEGF-A isoform
  JOURNAL   Nucleic Acids Res 36 (7), 2434-2445 (2008)
   PUBMED   18304943
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Huez,I., Bornes,S., Bresson,D., Creancier,L. and Prats,H.
  TITLE     New vascular endothelial growth factor isoform generated by
            internal ribosome entry site-driven CUG translation initiation
  JOURNAL   Mol Endocrinol 15 (12), 2197-2210 (2001)
   PUBMED   11731620
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Tee,M.K. and Jaffe,R.B.
  TITLE     A precursor form of vascular endothelial growth factor arises by
            initiation from an upstream in-frame CUG codon
  JOURNAL   Biochem J 359 (Pt 1), 219-226 (2001)
   PUBMED   11563986
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Meiron,M., Anunu,R., Scheinman,E.J., Hashmueli,S. and Levi,B.Z.
  TITLE     New isoforms of VEGF are translated from alternative initiation CUG
            codons located in its 5'UTR
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1053-1060 (2001)
   PUBMED   11352659
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Claffey,K.P., Wilkison,W.O. and Spiegelman,B.M.
  TITLE     Vascular endothelial growth factor. Regulation by cell
            differentiation and activated second messenger pathways
  JOURNAL   J Biol Chem 267 (23), 16317-16322 (1992)
   PUBMED   1644816
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY001490.1, CK626177.1,
            BC061468.1 and AK031905.1.
            
            Summary: This gene is a member of the PDGF/VEGF growth factor
            family. It encodes a heparin-binding protein, which exists as a
            disulfide-linked homodimer. This growth factor induces
            proliferation and migration of vascular endothelial cells, and is
            essential for both physiological and pathological angiogenesis.
            Disruption of this gene in mice resulted in abnormal embryonic
            blood vessel formation. This gene is upregulated in many known
            tumors and its expression is correlated with tumor stage and
            progression. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. There is also
            evidence for alternative translation initiation from upstream
            non-AUG (CUG) codons resulting in additional isoforms. A recent
            study showed that a C-terminally extended isoform is produced by
            use of an alternative in-frame translation termination codon via a
            stop codon readthrough mechanism, and that this isoform is
            antiangiogenic. Expression of some isoforms derived from the AUG
            start codon is regulated by a small upstream open reading frame,
            which is located within an internal ribosome entry site.[provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (3) lacks two consecutive in-frame
            coding exons, compared to variant 1. This variant can initiate
            translation from a non-AUG (CUG) site and also from a downstream,
            in-frame AUG site. The isoform (9) represented in this RefSeq is
            translated from the AUG start codon. It has a shorter N-terminus
            and also lacks an internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 18304943
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.79 cM"
     Protein         1..146
                     /product="vascular endothelial growth factor A, long form
                     isoform 9 precursor"
                     /note="vascular permeability factor; vascular endothelial
                     growth factor A, long form"
                     /calculated_mol_wt=14071
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3180
     mat_peptide     27..146
                     /product="vascular endothelial growth factor A, long form
                     isoform 9"
                     /calculated_mol_wt=14071
     Region          49..131
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; smart00141"
                     /db_xref="CDD:197537"
     Site            order(49..52,86,88..91,106..109)
                     /site_type="active"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     Site            order(51,82,86,93,127,129)
                     /site_type="other"
                     /note="cysteine knot motif"
                     /db_xref="CDD:238079"
     Site            order(76,85)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238079"
     CDS             1..146
                     /gene="Vegfa"
                     /gene_synonym="L-VEGF; Vegf; Vpf"
                     /coded_by="NM_001287058.1:1022..1462"
                     /note="isoform 9 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS70817.1"
                     /db_xref="GeneID:22339"
                     /db_xref="MGI:MGI:103178"
ORIGIN      
        1 mnfllswvhw tlalllylhh akwsqaaptt egeqkshevi kfmdvyqrsy crpietlvdi
       61 fqeypdeiey ifkpscvplm rcagccndea lecvptsesn itmqimrikp hqsqhigems
      121 flqhsrcecr pkkdrtkpek cdkprr
//
LOCUS       NP_031863                168 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA damage-inducible transcript 3 protein [Mus musculus].
ACCESSION   NP_031863
VERSION     NP_031863.3
DBSOURCE    REFSEQ: accession NM_007837.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 168)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 168)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 168)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 168)
  AUTHORS   Zhu,S., Huo,S., He,W., Huang,C., Zhang,J., Jiang,X., Qian,Y.,
            Chen,C., Dai,Z.M., Yang,X., Qiu,M., Li,T. and Zhu,X.J.
  TITLE     Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the
            mouse craniofacial development
  JOURNAL   iScience 28 (3), 111972 (2025)
   PUBMED   40071146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 168)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 168)
  AUTHORS   Jousse,C., Bruhat,A., Carraro,V., Urano,F., Ferrara,M., Ron,D. and
            Fafournoux,P.
  TITLE     Inhibition of CHOP translation by a peptide encoded by an open
            reading frame localized in the chop 5'UTR
  JOURNAL   Nucleic Acids Res 29 (21), 4341-4351 (2001)
   PUBMED   11691921
REFERENCE   7  (residues 1 to 168)
  AUTHORS   Zinszner,H., Kuroda,M., Wang,X., Batchvarova,N., Lightfoot,R.T.,
            Remotti,H., Stevens,J.L. and Ron,D.
  TITLE     CHOP is implicated in programmed cell death in response to impaired
            function of the endoplasmic reticulum
  JOURNAL   Genes Dev 12 (7), 982-995 (1998)
   PUBMED   9531536
REFERENCE   8  (residues 1 to 168)
  AUTHORS   Fleming,J.V., Fontanier,N., Harries,D.N. and Rees,W.D.
  TITLE     The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are
            expressed in the mouse preimplantation embryo
  JOURNAL   Mol Reprod Dev 48 (3), 310-316 (1997)
   PUBMED   9322241
REFERENCE   9  (residues 1 to 168)
  AUTHORS   Ubeda,M., Wang,X.Z., Zinszner,H., Wu,I., Habener,J.F. and Ron,D.
  TITLE     Stress-induced binding of the transcriptional factor CHOP to a
            novel DNA control element
  JOURNAL   Mol Cell Biol 16 (4), 1479-1489 (1996)
   PUBMED   8657121
REFERENCE   10 (residues 1 to 168)
  AUTHORS   Ron,D. and Habener,J.F.
  TITLE     CHOP, a novel developmentally regulated nuclear protein that
            dimerizes with transcription factors C/EBP and LAP and functions as
            a dominant-negative inhibitor of gene transcription
  JOURNAL   Genes Dev 6 (3), 439-453 (1992)
   PUBMED   1547942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144852.3.
            
            On Nov 20, 2007 this sequence version replaced NP_031863.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013718.1, SRR13861890.18473.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            regulatory uORF        :: PMID: 11691921
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     Protein         1..168
                     /product="DNA damage-inducible transcript 3 protein"
                     /note="C/EBP zeta; CCAAT/enhancer-binding protein
                     homologous protein; DDIT-3; growth arrest and
                     DNA-damage-inducible protein GADD153; c/EBP-homologous
                     protein 10; C/EBP homoologous protein 10; alternative
                     DDIT3 proteins"
                     /calculated_mol_wt=19058
     Region          10..26
                     /region_name="N-terminal. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Region          10..18
                     /region_name="Interaction with TRIB3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            31
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Region          34..139
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:8650547; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:8650547; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Region          100..160
                     /region_name="BRLZ"
                     /note="basic region leucin zipper; smart00338"
                     /db_xref="CDD:197664"
     Region          100..129
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Region          102..152
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269834"
     Site            order(104..105,107..109,111..116,118..120)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269834"
     Site            order(119,122..123,126..127,129..130,133..134,136..137,
                     140..141,143..144,147..148,150..151)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269834"
     Region          133..147
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     CDS             1..168
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /coded_by="NM_007837.5:167..673"
                     /db_xref="CCDS:CCDS24236.1"
                     /db_xref="GeneID:13198"
                     /db_xref="MGI:MGI:109247"
ORIGIN      
        1 maaeslpftl etvsswelea wyedlqevls sdeiggtyis spgneeeesk tfttldpasl
       61 awlteepgpt evtrtsqspr spdssqssma qeeeeeeqgr trkrkqsgqc parpgkqrmk
      121 ekeqenerkv aqlaeenerl kqeierltre vettrralid rmvslhqa
//
LOCUS       NP_071705                655 aa            linear   ROD 27-AUG-2025
DEFINITION  endoplasmic reticulum chaperone BiP precursor [Mus musculus].
ACCESSION   NP_071705
VERSION     NP_071705.3
DBSOURCE    REFSEQ: accession NM_022310.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 655)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 655)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 655)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 655)
  AUTHORS   Drazic Maras,E., Kelam,N., Racetin,A., Haque,E., Drazic,M.,
            Vukojevic,K., Katsuyama,Y., Saraga-Babic,M. and Filipovic,N.
  TITLE     Autophagy markers expression pattern in developing liver of the
            yotari (dab1-/-) mice and humans
  JOURNAL   Acta Histochem 127 (1), 152224 (2025)
   PUBMED   39647211
REFERENCE   5  (residues 1 to 655)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 655)
  AUTHORS   Haas,I.G., Simon-Chazottes,D. and Guenet,J.L.
  TITLE     The gene coding for the immunoglobulin heavy chain binding protein
            BiP (Hsce-70) maps to mouse chromosome 2
  JOURNAL   Mamm Genome 3 (11), 659-660 (1992)
   PUBMED   1450517
REFERENCE   7  (residues 1 to 655)
  AUTHORS   Gaskins,H.R., Prochazka,M. and Leiter,E.H.
  TITLE     Chromosomal localization of the murine stress protein gene encoding
            glucose-regulated protein 78 (BiP)
  JOURNAL   Mamm Genome 3 (12), 709-711 (1992)
   PUBMED   1362103
REFERENCE   8  (residues 1 to 655)
  AUTHORS   Kim,S.K., Kim,Y.K. and Lee,A.S.
  TITLE     Expression of the glucose-regulated proteins (GRP94 and GRP78) in
            differentiated and undifferentiated mouse embryonic cells and the
            use of the GRP78 promoter as an expression system in embryonic
            cells
  JOURNAL   Differentiation 42 (3), 153-159 (1990)
   PUBMED   1692794
REFERENCE   9  (residues 1 to 655)
  AUTHORS   Parfett,C.L., Hofbauer,R., Brudzynski,K., Edwards,D.R. and
            Denhardt,D.T.
  TITLE     Differential screening of a cDNA library with cDNA probes amplified
            in a heterologous host: isolation of murine GRP78 (BiP) and other
            serum-regulated low-abundance mRNAs
  JOURNAL   Gene 82 (2), 291-303 (1989)
   PUBMED   2583523
REFERENCE   10 (residues 1 to 655)
  AUTHORS   Kozutsumi,Y., Normington,K., Press,E., Slaughter,C., Sambrook,J.
            and Gething,M.J.
  TITLE     Identification of immunoglobulin heavy chain binding protein as
            glucose-regulated protein 78 on the basis of amino acid sequence,
            immunological cross-reactivity, and functional activity
  JOURNAL   J Cell Sci Suppl 11, 115-137 (1989)
   PUBMED   2559088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929106.5 and AK152521.1.
            
            On Jul 21, 2009 this sequence version replaced NP_071705.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050927.1, AK004578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.94 cM"
     Protein         1..655
                     /product="endoplasmic reticulum chaperone BiP precursor"
                     /EC_number="3.6.4.10"
                     /note="78 kDa glucose-regulated protein; GRP-78; heat
                     shock 70 kDa protein 5; immunoglobulin heavy chain-binding
                     protein; glucose regulated protein, 78 kDa; XAP-1 antigen;
                     heat shock 70kD protein 5 (glucose-regulated protein,
                     78kD); HSP70 family protein 5; binding-immunoglobulin
                     protein; heat shock protein family A member 5; heat shock
                     protein 70 family protein 5; endoplasmic reticulum
                     chaperone BiP"
                     /calculated_mol_wt=70465
     Region          1..81
                     /region_name="Required for interaction with ELAPOR1.
                     /evidence=ECO:0000250|UniProtKB:P11021"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1976
     mat_peptide     20..655
                     /product="Endoplasmic reticulum chaperone BiP.
                     /id=PRO_0000013568"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
                     /calculated_mol_wt=70465
     Region          31..636
                     /region_name="HSP70"
                     /note="Hsp70 protein; pfam00012"
                     /db_xref="CDD:394970"
     Site            87
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06761; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Region          126..281
                     /region_name="Nucleotide-binding (NBD).
                     /evidence=ECO:0000250|UniProtKB:P11021"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     Site            126
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            214
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            272
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            327
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            354
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Region          410..420
                     /region_name="Interdomain linker.
                     /evidence=ECO:0000250|UniProtKB:G3I8R9"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     Region          421..501
                     /region_name="Substrate-binding (SBD).
                     /evidence=ECO:0000250|UniProtKB:P11021"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     Site            493
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P0DMV8; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            519
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P11021; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            586
                     /site_type="methylation"
                     /note="N6,N6,N6-trimethyllysine, by METTL21A, in vitro.
                     /evidence=ECO:0000269|PubMed:23921388;
                     N6,N6-dimethyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P11021; N6-methyllysine,
                     alternate. /evidence=ECO:0000250|UniProtKB:P11021;
                     propagated from UniProtKB/Swiss-Prot (P20029.3)"
     Site            592
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P11021; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Region          632..655
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     Site            644
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Site            650
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P20029.3)"
     Region          652..655
                     /region_name="Prevents secretion from ER"
                     /note="propagated from UniProtKB/Swiss-Prot (P20029.3)"
     CDS             1..655
                     /gene="Hspa5"
                     /gene_synonym="baffled; Bip; D2Wsu141e; D2Wsu17e; Grp78;
                     Hsce70; mBiP; SEZ-7; Sez7"
                     /coded_by="NM_022310.3:233..2200"
                     /db_xref="CCDS:CCDS15950.1"
                     /db_xref="GeneID:14828"
                     /db_xref="MGI:MGI:95835"
ORIGIN      
        1 mmkftvvaaa llllgavrae eedkkedvgt vvgidlgtty scvgvfkngr veiiandqgn
       61 ritpsyvaft pegerligda aknqltsnpe ntvfdakrli grtwndpsvq qdikflpfkv
      121 vekktkpyiq vdigggqtkt fapeeisamv ltkmketaea ylgkkvthav vtvpayfnda
      181 qrqatkdagt iaglnvmrii neptaaaiay gldkregekn ilvfdlgggt fdvslltidn
      241 gvfevvatng dthlggedfd qrvmehfikl ykkktgkdvr kdnravqklr revekakral
      301 ssqhqariei esffegedfs etltrakfee lnmdlfrstm kpvqkvleds dlkksdidei
      361 vlvggstrip kiqqlvkeff ngkepsrgin pdeavaygaa vqagvlsgdq dtgdlvlldv
      421 cpltlgietv ggvmtklipr ntvvptkksq ifstasdnqp tvtikvyege rpltkdnhll
      481 gtfdltgipp aprgvpqiev tfeidvngil rvtaedkgtg nknkititnd qnrltpeeie
      541 rmvndaekfa eedkklkeri dtrnelesya yslknqigdk eklggklsse dketmekave
      601 ekiewleshq dadiedfkak kkeleeivqp iisklygsgg ppptgeedts ekdel
//
LOCUS       NP_033309                749 aa            linear   ROD 27-AUG-2025
DEFINITION  signal transducer and activator of transcription 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_033309
VERSION     NP_033309.3
DBSOURCE    REFSEQ: accession NM_009283.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Risley,C.A., Schultz,M.D., Allie,S.R., Liu,S., Peel,J.N.,
            Nellore,A., Fucile,C.F., Scharer,C.D., Boss,J.M., Randall,T.D.,
            Rosenberg,A.F. and Lund,F.E.
  TITLE     Transcription factor T-bet regulates the maintenance and
            differentiation potential of lymph node and lung effector memory B
            cell subsets
  JOURNAL   Immunity 58 (7), 1706-1724 (2025)
   PUBMED   40543512
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Philips,R.L., Liao,Y.C., Lau,C.M., Morrison,T.A., Jiang,K.,
            Hutchinson,A., Shayne,J., Yao,C., Sun,J.C., Hickman,H.D.,
            Milner,J.D., Holland,S., Kanno,Y., Lionakis,M.S. and O'Shea,J.J.
  TITLE     An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte
            programs during viral infection
  JOURNAL   Sci Immunol 10 (107), eado5986 (2025)
   PUBMED   40446018
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Novak,U., Harpur,A.G., Paradiso,L., Kanagasundaram,V.,
            Jaworowski,A., Wilks,A.F. and Hamilton,J.A.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Finidori,J. and Kelly,P.A.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Harroch,S., Gothelf,Y., Revel,M. and Chebath,J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Matsuda,T. and Hirano,T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039458.1, AK082706.1, AC123752.8, BC042551.1 and BX513160.1.
            
            On Sep 14, 2006 this sequence version replaced NP_033309.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform 2),
            compared to isoform 1. Variants 2, 3, and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082706.1, AK159887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..749
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /calculated_mol_wt=87184
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            114
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            175
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            296
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          317..477
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,459..460,463)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Site            366
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            525
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          557..707
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(584,602,630,632)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(631,647)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            637
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(641..642,706)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            665
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK1, JAK2 or TYK2.
                     /evidence=ECO:0000269|PubMed:19088846,
                     ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:38621137;
                     propagated from UniProtKB/Swiss-Prot (P42225.1)"
     Site            708
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000269|PubMed:17332413,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          715..739
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     Site            724
                     /site_type="other"
                     /note="Required for recruitment of EP300/p300.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2 and MAPK14.
                     /evidence=ECO:0000269|PubMed:11972023,
                     ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:38621137;
                     propagated from UniProtKB/Swiss-Prot (P42225.1)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000305|PubMed:17332413; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            748
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by IKKB.
                     /evidence=ECO:0000269|PubMed:38621137; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     CDS             1..749
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_009283.4:351..2600"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlet tslpvvvisn vsqlpsgwas ilwynmlvte
      481 prnlsfflnp pcawwsqlse vlswqfssvt krglnadqls mlgekllgpn agpdglipwt
      541 rfckenindk nfsfwpwidt ilelikkhll clwndgcimg fiskereral lkdqqpgtfl
      601 lrfsessreg aitftwvers qnggepdfha vepytkkels avtfpdiirn ykvmaaenip
      661 enplkylypn idkdhafgky ysrpkeapep melddpkrtg yiktelisvs evhpsrlqtt
      721 dnllpmspee fdemsrivgp efdsmmstv
//
LOCUS       NP_001231129             436 aa            linear   ROD 27-AUG-2025
DEFINITION  paired box protein Pax-6 isoform 1 [Mus musculus].
ACCESSION   NP_001231129
VERSION     NP_001231129.1
DBSOURCE    REFSEQ: accession NM_001244200.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 436)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 436)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 436)
  AUTHORS   Georgala,P.A., Carr,C.B. and Price,D.J.
  TITLE     The role of Pax6 in forebrain development
  JOURNAL   Dev Neurobiol 71 (8), 690-709 (2011)
   PUBMED   21538923
  REMARK    Review article
REFERENCE   4  (residues 1 to 436)
  AUTHORS   Kim,J. and Lauderdale,J.D.
  TITLE     Analysis of Pax6 expression using a BAC transgene reveals the
            presence of a paired-less isoform of Pax6 in the eye and olfactory
            bulb
  JOURNAL   Dev Biol 292 (2), 486-505 (2006)
   PUBMED   16464444
  REMARK    GeneRIF: Pax6 expression, analyzed using a BAC transgene, revealed
            the presence of a paired-less isoform in the eye and olfactory
            bulb.
REFERENCE   5  (residues 1 to 436)
  AUTHORS   Xu,P.X., Zhang,X., Heaney,S., Yoon,A., Michelson,A.M. and Maas,R.L.
  TITLE     Regulation of Pax6 expression is conserved between mice and flies
  JOURNAL   Development 126 (2), 383-395 (1999)
   PUBMED   9847251
REFERENCE   6  (residues 1 to 436)
  AUTHORS   Ton,C.C., Miwa,H. and Saunders,G.F.
  TITLE     Small eye (Sey): cloning and characterization of the murine homolog
            of the human aniridia gene
  JOURNAL   Genomics 13 (2), 251-256 (1992)
   PUBMED   1612585
REFERENCE   7  (residues 1 to 436)
  AUTHORS   Hill,R.E., Favor,J., Hogan,B.L., Ton,C.C., Saunders,G.F.,
            Hanson,I.M., Prosser,J., Jordan,T., Hastie,N.D. and van
            Heyningen,V.
  TITLE     Mouse small eye results from mutations in a paired-like
            homeobox-containing gene
  JOURNAL   Nature 354 (6354), 522-525 (1991)
   PUBMED   1684639
  REMARK    Erratum:[Nature. 1992 Feb 20;355(6362):750. doi: 10.1038/355750a0.
            PMID: 1346927]
REFERENCE   8  (residues 1 to 436)
  AUTHORS   Walther,C. and Gruss,P.
  TITLE     Pax-6, a murine paired box gene, is expressed in the developing CNS
  JOURNAL   Development 113 (4), 1435-1449 (1991)
   PUBMED   1687460
REFERENCE   9  (residues 1 to 436)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (residues 1 to 436)
  AUTHORS   Theiler,K., Varnum,D.S. and Stevens,L.C.
  TITLE     Development of Dickie's small eye, a mutation in the house mouse
  JOURNAL   Anat Embryol (Berl) 155 (1), 81-86 (1978)
   PUBMED   103464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY064175.1, CN538503.1,
            CX565124.1, CN539723.1, AK139054.1 and AL512589.4.
            
            Summary: This gene encodes a homeobox-containing protein that
            functions as a regulator of transcription. It plays a key role in
            the development of neural tissues, particularly the eye. Activity
            of this protein is also required for expression of glucagon in the
            pancreas. This gene is regulated by multiple enhancers located up
            to tens or hundreds of kilobases upstream and downstream of the
            transcription start sites. Mutations in this gene or deletion of
            these regulatory elements results in severe defects in eye
            development. Alternative splicing and the use of alternative
            promoters results in multiple transcript variants, some of which
            encode proteins that lack the N-terminal paired domain. [provided
            by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. It initiates from the P1 promoter. Variants 1, 2, and
            3 encode the same protein (isoform 1, also known as 5a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63963.1, SRR9219380.85767.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.31 cM"
     Protein         1..436
                     /product="paired box protein Pax-6 isoform 1"
                     /note="paired box protein Pax-6; oculorhombin; Dickie's
                     small eye; paired box gene 6"
                     /calculated_mol_wt=48088
     Region          4..142
                     /region_name="PAX"
                     /note="Paired Box domain; smart00351"
                     /db_xref="CDD:128645"
     Site            order(9..10,15,17..19,21,26,38,40,63,66,68..69,73,82..88,
                     90..93,112..114,133,135..136,139,142)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238076"
     Region          226..281
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..436
                     /gene="Pax6"
                     /gene_synonym="1500038E17Rik; AEY11; Dey; Gsfaey11; Pax-6;
                     Sey"
                     /coded_by="NM_001244200.2:361..1671"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS16499.1"
                     /db_xref="GeneID:18508"
                     /db_xref="MGI:MGI:97490"
ORIGIN      
        1 mqnshsgvnq lggvfvngrp lpdstrqkiv elahsgarpc disrilqtha dakvqvldne
       61 nvsngcvski lgryyetgsi rpraiggskp rvatpevvsk iaqykrecps ifaweirdrl
      121 lsegvctndn ipsvssinrv lrnlasekqq mgadgmydkl rmlngqtgsw gtrpgwypgt
      181 svpgqptqdg cqqqegggen tnsissnged sdeaqmrlql krklqrnrts ftqeqieale
      241 keferthypd vfarerlaak idlpeariqv wfsnrrakwr reeklrnqrr qasntpship
      301 isssfstsvy qpipqpttpv ssftsgsmlg rtdtaltnty salppmpsft mannlpmqpp
      361 vpsqtssysc mlptspsvng rsydtytpph mqthmnsqpm gtsgttstgl ispgvsvpvq
      421 vpgsepdmsq ywprlq
//
LOCUS       NP_001074543             595 aa            linear   ROD 27-AUG-2025
DEFINITION  APOBEC1 complementation factor isoform 1 [Mus musculus].
ACCESSION   NP_001074543 XP_129159
VERSION     NP_001074543.1
DBSOURCE    REFSEQ: accession NM_001081074.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 595)
  AUTHORS   Qian,S., Zhang,C., Li,W., Song,S., Lin,G., Cheng,Z., Zhou,W.,
            Yin,H., Wang,Y., Li,H., Shen,Y.H. and Sun,Z.
  TITLE     Enzyme-independent functions of HDAC3 in the adult heart
  JOURNAL   Acta Pharm Sin B 15 (7), 3561-3574 (2025)
   PUBMED   40698142
REFERENCE   2  (residues 1 to 595)
  AUTHORS   Ruan,W., Li,T., Bang,I.H., Lee,J., Deng,W., Ma,X., Luo,C., Du,F.,
            Yoo,S.H., Kim,B., Li,J., Yuan,X., Figarella,K., An,Y.A., Wang,Y.Y.,
            Liang,Y., DeBerge,M., Zhang,D., Zhou,Z., Wang,Y., Gorham,J.M.,
            Seidman,J.G., Seidman,C.E., Aranki,S.F., Nair,R., Li,L., Narula,J.,
            Zhao,Z., Gorfe,A.A., Muehlschlegel,J.D., Tsai,K.L. and
            Eltzschig,H.K.
  TITLE     BMAL1-HIF2A heterodimer modulates circadian variations of
            myocardial injury
  JOURNAL   Nature 641 (8064), 1017-1028 (2025)
   PUBMED   40269168
REFERENCE   3  (residues 1 to 595)
  AUTHORS   Fuchs,M.A.A., Burke,E.J., Latic,N., Murray,S.L., Li,H.,
            Sparks,M.A., Abraham,D., Zhang,H., Rosenberg,P., Saleem,U.,
            Hansen,A., Miller,S.E., Ferreira,D., Hanzelmann,S., Hausmann,F.,
            Huber,T., Erben,R.G., Fisher-Wellman,K., Bursac,N., Wolf,M. and
            Grabner,A.
  TITLE     Fibroblast growth factor 23 and fibroblast growth factor receptor 4
            promote cardiac metabolic remodeling in chronic kidney disease
  JOURNAL   Kidney Int 107 (5), 852-868 (2025)
   PUBMED   39923962
REFERENCE   4  (residues 1 to 595)
  AUTHORS   Perelli,R.M., Dewars,E.R., Cope,H., Behura,A.S., Ponek,A.Q.,
            Sala,A.M., Zhang,Z., Muralidharan,P., Moya-Mendez,M.E., Berkman,A.,
            Monaco,G.G., Sullivan,M.C., Ezekian,J.E., Yang,Q., Sun,B.,
            Kurzlechner,L.M., Asokan,T., Breglio,A.M., Campbell,M.J.,
            Spector,Z.Z., Rehder,C.W., Tang,P.C., James,C.A., Calkins,H.,
            Shashi,V. and Landstrom,A.P.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic
            Cardiomyopathy
  JOURNAL   Circ Res 136 (7), 667-684 (2025)
   PUBMED   39963794
REFERENCE   5  (residues 1 to 595)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   6  (residues 1 to 595)
  AUTHORS   Dur,S., Krause,K., Pluntke,N. and Greeve,J.
  TITLE     Gene structure and expression of the mouse APOBEC-1 complementation
            factor: multiple transcriptional initiation sites and a spliced
            variant with a premature stop translation codon
  JOURNAL   Biochim Biophys Acta 1680 (1), 11-23 (2004)
   PUBMED   15451168
REFERENCE   7  (residues 1 to 595)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (residues 1 to 595)
  AUTHORS   Petrich,B.G., Molkentin,J.D. and Wang,Y.
  TITLE     Temporal activation of c-Jun N-terminal kinase in adult transgenic
            heart via cre-loxP-mediated DNA recombination
  JOURNAL   FASEB J 17 (6), 749-751 (2003)
   PUBMED   12594183
REFERENCE   9  (residues 1 to 595)
  AUTHORS   Sohal,D.S., Nghiem,M., Crackower,M.A., Witt,S.A., Kimball,T.R.,
            Tymitz,K.M., Penninger,J.M. and Molkentin,J.D.
  TITLE     Temporally regulated and tissue-specific gene manipulations in the
            adult and embryonic heart using a tamoxifen-inducible Cre protein
  JOURNAL   Circ Res 89 (1), 20-25 (2001)
   PUBMED   11440973
REFERENCE   10 (residues 1 to 595)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125019.6 and AC117816.11.
            
            On Feb 6, 2007 this sequence version replaced XP_129159.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     Protein         1..595
                     /product="APOBEC1 complementation factor isoform 1"
                     /note="APOBEC-1 stimulating protein"
                     /calculated_mol_wt=65551
     Region          2..595
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     Region          360..409
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:Q9NQ94"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5YD48.2)"
     CDS             1..595
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /coded_by="NM_001081074.2:93..1880"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37959.1"
                     /db_xref="GeneID:69865"
                     /db_xref="MGI:MGI:1917115"
ORIGIN      
        1 mesnhksgdg lsgtqkeaal ralvqrtgys lvqengqrky ggpppgwdst ppergceifi
       61 gklprdlfed eliplcekig kiyemrlmmd fngnnrgyaf vtfsnkqeak naikqlnnye
      121 irtgrllgvc asvdncrlfv ggipktkkre eilsemkkvt egvvdvivyp saadktknrg
      181 fafveyeshr aaamarrrll pgriqlwghp iavdwaepev evdedtmssv kilyvrnlml
      241 stseemieke fnsikpgave rvkkirdyaf vhfsnredav eamkalngkv ldgspievtl
      301 akpvdkdsyv rytrgtggrn tmlqgeytyp lshvydpttt ylgapvfytp qayaaipslh
      361 fpatkghlsn ralirtpsvr eiymnvpvga agvrglggrg ylaytglgrg yhvkgdkred
      421 klydllpgme ltpmntvslk pqgiklapqi leeicqknnw gqpvyqlhsa igqdqrqlfl
      481 ykvtipalas qnpaihpfip pklsayvdea kryaaehtlq tlgipteggd agttaptats
      541 atvfpgyavp satapvstaq lkqavtlgqd laayttyevy ptfalttrgd aygtf
//
LOCUS       NP_001403712             284 aa            linear   ROD 27-AUG-2025
DEFINITION  deoxyribonuclease-1 precursor [Mus musculus].
ACCESSION   NP_001403712 XP_006521839
VERSION     NP_001403712.1
DBSOURCE    REFSEQ: accession NM_001416783.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 284)
  AUTHORS   Englert,H., Rangaswamy,C., Kullik,G.A., Divivier,M., Gobel,J.,
            Hermans-Borgmeyer,I., Borgmeyer,U., Mowen,K.A., Beerens,M.,
            Frye,M., Mailer,R.K., Gelderblom,M., Stavrou,E.X., Preston,R.J.S.,
            Schneider,S.W., Fuchs,T.A. and Renne,T.
  TITLE     Sepsis-induced NET formation requires MYD88 but is independent of
            GSDMD and PAD4
  JOURNAL   FASEB J 39 (1), e70301 (2025)
   PUBMED   39777764
REFERENCE   2  (residues 1 to 284)
  AUTHORS   Stabach,P.R., Sims,D., Gomez-Banuelos,E., Zehentmeier,S.,
            Dammen-Brower,K., Bernhisel,A., Kujawski,S., Lopez,S.G., Petri,M.,
            Goldman,D.W., Lester,E.R., Le,Q., Ishaq,T., Kim,H., Srivastava,S.,
            Kumar,D., Pereira,J.P., Yarema,K.J., Koumpouras,F., Andrade,F. and
            Braddock,D.T.
  TITLE     A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and
            death in genetic and induced lupus models
  JOURNAL   JCI Insight 9 (14), e177003 (2024)
   PUBMED   38888971
  REMARK    GeneRIF: A dual-acting DNASE1/DNASE1L3 biologic prevents
            autoimmunity and death in genetic and induced lupus models.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 284)
  AUTHORS   Willemsen,J.F., Wenskus,J., Lenz,M., Rhode,H., Trochimiuk,M.,
            Appl,B., Pagarol-Raluy,L., Bornigen,D., Bang,C., Reinshagen,K.,
            Herrmann,M., Elrod,J. and Boettcher,M.
  TITLE     DNases improve effectiveness of antibiotic treatment in murine
            polymicrobial sepsis
  JOURNAL   Front Immunol 14, 1254838 (2024)
   PUBMED   38259485
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 284)
  AUTHORS   Elrod,J., Heuer,A., Knopf,J., Schoen,J., Schonfeld,L.,
            Trochimiuk,M., Stiel,C., Appl,B., Raluy,L.P., Saygi,C., Zlatar,L.,
            Hosari,S., Royzman,D., Winkler,T.H., Lochnit,G., Leppkes,M.,
            Grutzmann,R., Schett,G., Tomuschat,C., Reinshagen,K., Herrmann,M.,
            Fuchs,T.A. and Boettcher,M.
  TITLE     Neutrophil extracellular traps and DNases orchestrate formation of
            peritoneal adhesions
  JOURNAL   iScience 26 (12), 108289 (2023)
   PUBMED   38034352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 284)
  AUTHORS   Napirei,M., Karsunky,H., Zevnik,B., Stephan,H., Mannherz,H.G. and
            Moroy,T.
  TITLE     Features of systemic lupus erythematosus in Dnase1-deficient mice
  JOURNAL   Nat Genet 25 (2), 177-181 (2000)
   PUBMED   10835632
REFERENCE   7  (residues 1 to 284)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   8  (residues 1 to 284)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 284)
  AUTHORS   Takeshita,H., Yasuda,T., Nakajima,T., Hosomi,O., Nakashima,Y. and
            Kishi,K.
  TITLE     Mouse deoxyribonuclease I (DNase I): biochemical and immunological
            characterization, cDNA structure and tissue distribution
  JOURNAL   Biochem Mol Biol Int 42 (1), 65-75 (1997)
   PUBMED   9192086
REFERENCE   10 (residues 1 to 284)
  AUTHORS   Peitsch,M.C., Irmler,M., French,L.E. and Tschopp,J.
  TITLE     Genomic organisation and expression of mouse deoxyribonuclease I
  JOURNAL   Biochem Biophys Res Commun 207 (1), 62-68 (1995)
   PUBMED   7857306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087900.19.
            
            On Feb 16, 2023 this sequence version replaced XP_006521839.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.172084.1,
                                           SRR5189682.93160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.37 cM"
     Protein         1..284
                     /product="deoxyribonuclease-1 precursor"
                     /EC_number="3.1.21.1"
                     /note="deoxyribonuclease-1"
                     /calculated_mol_wt=29666
     sig_peptide     1..22
                     /note="/evidence=ECO:0000250|UniProtKB:P00639; propagated
                     from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=2380
     Region          20..282
                     /region_name="DNaseIc"
                     /note="deoxyribonuclease I; smart00476"
                     /db_xref="CDD:128752"
     mat_peptide     23..284
                     /product="Deoxyribonuclease-1. /id=PRO_0000007278"
                     /note="propagated from UniProtKB/Swiss-Prot (P49183.2)"
                     /calculated_mol_wt=29666
     Site            order(29..30,32,36,61,63..65,97..98,100,133,156,159,190,
                     192,197,229,233..234,273..274)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,100,156,190,192,234,273..274)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197337"
     Site            order(29,61,273)
                     /site_type="other"
                     /note="putative Mg binding site IVb [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(31,156,190,192,274)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197337"
     Site            31
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:197337"
     Site            order(32,36,63..65,97..98,100,133,156,159,190,192,197,233,
                     274)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:197337"
     Site            35
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            40
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            87
                     /site_type="other"
                     /note="Nitration by tetranitromethane destroys a Ca(2+)
                     binding site and inactivates enzyme.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            89
                     /site_type="other"
                     /note="Involved in actin-binding.
                     /evidence=ECO:0000250|UniProtKB:P00639; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(121,134)
                     /site_type="other"
                     /note="Ca binding site II [ion binding]"
                     /db_xref="CDD:197337"
     Site            128
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P49183.2)"
     Site            order(190,234,274)
                     /site_type="other"
                     /note="putative Mg binding site IVa [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(194,220)
                     /site_type="metal-binding"
                     /note="metal binding site III [ion binding]"
                     /db_xref="CDD:197337"
     Site            order(223,225)
                     /site_type="other"
                     /note="Ca binding site I [ion binding]"
                     /db_xref="CDD:197337"
     CDS             1..284
                     /gene="Dnase1"
                     /gene_synonym="DNaseI; Dnl1"
                     /coded_by="NM_001416783.1:214..1068"
                     /db_xref="GeneID:13419"
                     /db_xref="MGI:MGI:103157"
ORIGIN      
        1 mrytglmgtl ltlvnllqla gtlriaafni rtfgetkmsn atlsvyfvki lsrydiaviq
       61 evrdshlvav gklldelnrd kpdtyryvvs eplgrksyke qylfvyrpdq vsildsyqyd
      121 dgcepcgndt fsrepaivkf fspytevqef aivplhaapt eavseidaly dvyldvwqkw
      181 gledimfmgd fnagcsyvts sqwssirlrt spifqwlipd sadttvtsth caydrivvag
      241 allqaavvpn savpfdfqae yglsnqlaea isdhypvevt lrki
//
LOCUS       NP_001153021             437 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor subfamily 6 group A member 1 isoform 3 [Mus
            musculus].
ACCESSION   NP_001153021
VERSION     NP_001153021.1
DBSOURCE    REFSEQ: accession NM_001159549.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Neelathi,U.M., Ullah,E., George,A., Maftei,M.I., Boobalan,E.,
            Sanchez-Mendoza,D., Adams,C., McGaughey,D., Sergeev,Y.V., Ai
            Rawi,R., Naik,A., Bender,C., Maumenee,I.H., Michaelides,M.,
            Tan,T.G., Lin,S., Villasmil,R., Blain,D., Hufnagel,R.B., Arno,G.,
            Young,R.M., Guan,B. and Brooks,B.P.
  TITLE     Variants in NR6A1 cause a novel oculo vertebral renal syndrome
  JOURNAL   Nat Commun 16 (1), 6111 (2025)
   PUBMED   40610405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Chang,Y.C., Manent,J., Schroeder,J., Wong,S.F.L., Hauswirth,G.M.,
            Shylo,N.A., Moore,E.L., Achilleos,A., Garside,V., Polo,J.M.,
            Trainor,P. and McGlinn,E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Tan,P., Xue,T., Wang,Y., Hu,Z., Su,J., Yang,R., Ji,J., Ye,M.,
            Chen,Z., Huang,C. and Lu,X.
  TITLE     Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the
            development of depression-like behaviors in mice
  JOURNAL   Neuropharmacology 209, 108990 (2022)
   PUBMED   35183538
  REMARK    GeneRIF: Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to
            the development of depression-like behaviors in mice.
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Koutelou,E., Wang,L., Schibler,A.C., Chao,H.P., Kuang,X., Lin,K.,
            Lu,Y., Shen,J., Jeter,C.R., Salinger,A., Wilson,M., Chen,Y.C.,
            Atanassov,B.S., Tang,D.G. and Dent,S.Y.R.
  TITLE     USP22 controls multiple signaling pathways that are essential for
            vasculature formation in the mouse placenta
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30718289
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Kapelle,M., Kratzschmar,J., Husemann,M. and Schleuning,W.D.
  TITLE     cDNA cloning of two closely related forms of human germ cell
            nuclear factor (GCNF)
  JOURNAL   Biochim Biophys Acta 1352 (1), 13-17 (1997)
   PUBMED   9177477
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Yan,Z.H., Medvedev,A., Hirose,T., Gotoh,H. and Jetten,A.M.
  TITLE     Characterization of the response element and DNA binding properties
            of the nuclear orphan receptor germ cell nuclear factor/retinoid
            receptor-related testis-associated receptor
  JOURNAL   J Biol Chem 272 (16), 10565-10572 (1997)
   PUBMED   9099702
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Joos,T.O., David,R. and Dreyer,C.
  TITLE     xGCNF, a nuclear orphan receptor is expressed during neurulation in
            Xenopus laevis
  JOURNAL   Mech Dev 60 (1), 45-57 (1996)
   PUBMED   9025060
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Hirose,T., O'Brien,D.A. and Jetten,A.M.
  TITLE     RTR: a new member of the nuclear receptor superfamily that is
            highly expressed in murine testis
  JOURNAL   Gene 152 (2), 247-251 (1995)
   PUBMED   7835709
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN537407.1, CN537360.1, CK638822.1, CN532747.1 and AL844842.29.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.1417267.1,
                                           SRR17784651.1076276.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     Protein         1..437
                     /product="nuclear receptor subfamily 6 group A member 1
                     isoform 3"
                     /note="mGCNF; retinoid receptor-related testis-specific
                     receptor; germ cell nuclear factor"
                     /calculated_mol_wt=50227
     Region          10..99
                     /region_name="NR_DBD_GCNF_like"
                     /note="DNA-binding domain of Germ cell nuclear factor
                     (GCNF) F1 is composed of two C4-type zinc fingers;
                     cd07169"
                     /db_xref="CDD:143543"
     Site            order(18,21,35,38,54,60,70,73)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143543"
     Site            order(28..30,36..37,39,41,44,47,67..68,71,74,85,88)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143543"
     Region          213..424
                     /region_name="NR_LBD_DHR4_like"
                     /note="The ligand binding domain of orphan nuclear
                     receptor Ecdysone-induced receptor DHR4; cd06953"
                     /db_xref="CDD:132751"
     Site            order(243..244,248,282,286,289,303,326)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:132751"
     Site            order(253,256,260,265,270..271,273..274,277..278)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132751"
     CDS             1..437
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /coded_by="NM_001159549.1:108..1421"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
ORIGIN      
        1 metwevsvpd draeqrtcli cgdratglhy giiscegckg ffkrsicnkr vyrcsrdknc
       61 vmsrkqrnrc qycrllkclq mgmnrkaire dgmpggrnks igpvqiseee ierimsgqef
      121 eeeanhwsnh gdsdhsspgn rasesnqpsp gstlssrsve lngfmafrdq ymgmsvpphy
      181 qyiphlfsys ghspllppqa rsldpqsysl ihqlmsaedl eplgtpmlie dgyavtqael
      241 fallcrlade llfrqiawik klpffcelsi kdytcllsst wqelillssl tvyskqifge
      301 ladvtakysp sdeelhrfsd egmevierli ylyhkfhqlk vsneeyacmk ainflnqdir
      361 gltsasqleq lnkrywyicq dfteykythq pnrfpdlmmc lpeiryiagk mvnvpleqlp
      421 llfkvvlhsc ktstvke
//
LOCUS       NP_080684                915 aa            linear   ROD 27-AUG-2025
DEFINITION  synphilin-1 isoform 2 [Mus musculus].
ACCESSION   NP_080684
VERSION     NP_080684.3
DBSOURCE    REFSEQ: accession NM_026408.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 915)
  AUTHORS   Dutta,D., Paidi,R.K., Raha,S., Roy,A., Chandra,S. and Pahan,K.
  TITLE     Treadmill exercise reduces alpha-synuclein spreading via PPARalpha
  JOURNAL   Cell Rep 40 (2), 111058 (2022)
   PUBMED   35830804
  REMARK    GeneRIF: Treadmill exercise reduces alpha-synuclein spreading via
            PPARalpha.
            Erratum:[Cell Rep. 2024 Aug 27;43(8):114546. doi:
            10.1016/j.celrep.2024.114546. PMID: 39024097]
REFERENCE   2  (residues 1 to 915)
  AUTHORS   Won,S.Y., Park,J.J., You,S.T., Hyeun,J.A., Kim,H.K., Jin,B.K.,
            McLean,C., Shin,E.Y. and Kim,E.G.
  TITLE     p21-activated kinase 4 controls the aggregation of alpha-synuclein
            by reducing the monomeric and aggregated forms of alpha-synuclein:
            involvement of the E3 ubiquitin ligase NEDD4-1
  JOURNAL   Cell Death Dis 13 (6), 575 (2022)
   PUBMED   35773260
  REMARK    GeneRIF: p21-activated kinase 4 controls the aggregation of
            alpha-synuclein by reducing the monomeric and aggregated forms of
            alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 915)
  AUTHORS   Chen,D.D., Gao,L.P., Wu,Y.Z., Chen,J., Hu,C., Xiao,K., Chen,C.,
            Shi,Q. and Dong,X.P.
  TITLE     Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells
  JOURNAL   ACS Chem Neurosci 12 (20), 3838-3854 (2021)
   PUBMED   34595918
  REMARK    GeneRIF: Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells.
REFERENCE   4  (residues 1 to 915)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 915)
  AUTHORS   Han,J.Y., Shin,C. and Choi,Y.P.
  TITLE     Preclinical Detection of Alpha-Synuclein Seeding Activity in the
            Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
  JOURNAL   Viruses 13 (5), 759 (2021)
   PUBMED   33926043
  REMARK    GeneRIF: Preclinical Detection of Alpha-Synuclein Seeding Activity
            in the Colon of a Transgenic Mouse Model of Synucleinopathy by
            RT-QuIC.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 915)
  AUTHORS   Soehn,A.S., Franck,T., Biskup,S., Giaime,E., Melle,C., Rott,R.,
            Cebo,D., Kalbacher,H., Ott,E., Pahnke,J., Meitinger,T., Kruger,R.,
            Gasser,T., Berg,D., von Eggeling,F., Engelender,S., da Costa,C.A.
            and Riess,O.
  TITLE     Periphilin is a novel interactor of synphilin-1, a protein
            implicated in Parkinson's disease
  JOURNAL   Neurogenetics 11 (2), 203-215 (2010)
   PUBMED   19730898
REFERENCE   7  (residues 1 to 915)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   8  (residues 1 to 915)
  AUTHORS   Kuhn,K., Zhu,X.R., Lubbert,H. and Stichel,C.C.
  TITLE     Parkin expression in the developing mouse
  JOURNAL   Brain Res Dev Brain Res 149 (2), 131-142 (2004)
   PUBMED   15063093
REFERENCE   9  (residues 1 to 915)
  AUTHORS   Goldberg,M.S., Fleming,S.M., Palacino,J.J., Cepeda,C., Lam,H.A.,
            Bhatnagar,A., Meloni,E.G., Wu,N., Ackerson,L.C., Klapstein,G.J.,
            Gajendiran,M., Roth,B.L., Chesselet,M.F., Maidment,N.T.,
            Levine,M.S. and Shen,J.
  TITLE     Parkin-deficient mice exhibit nigrostriatal deficits but not loss
            of dopaminergic neurons
  JOURNAL   J Biol Chem 278 (44), 43628-43635 (2003)
   PUBMED   12930822
REFERENCE   10 (residues 1 to 915)
  AUTHORS   O'Farrell,C., Pickford,F., Vink,L., McGowan,E. and Cookson,M.R.
  TITLE     Sequence conservation between mouse and human synphilin-1
  JOURNAL   Neurosci Lett 322 (1), 9-12 (2002)
   PUBMED   11958831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121943.3 and AC124178.3.
            
            On Nov 23, 2010 this sequence version replaced NP_080684.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.27 cM"
     Protein         1..915
                     /product="synphilin-1 isoform 2"
                     /note="alpha-synuclein-interacting protein; synphilin-1"
                     /calculated_mol_wt=99903
     Region          80..99
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          104..137
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          222..249
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          <321..508
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(348,350,354..355,358..360,362..363,367,372,381,383,
                     385,424..425,428..430,432..433,437,444,453,455,457,
                     461..462,465..467,469..470,474,477,486)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          348..381
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          348..379
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          383..453
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          383..412
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          418..447
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          455..486
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          455..484
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          511..554
                     /region_name="SNCAIP_SNCA_bd"
                     /note="Synphilin-1 alpha-Synuclein-binding domain;
                     pfam16700"
                     /db_xref="CDD:435527"
     Region          548..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          602..631
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     Region          667..852
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99ME3.2)"
     CDS             1..915
                     /gene="Sncaip"
                     /gene_synonym="2810407O15Rik; 4933427B05Rik; SYPH1"
                     /coded_by="NM_026408.5:198..2945"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS37820.2"
                     /db_xref="GeneID:67847"
                     /db_xref="MGI:MGI:1915097"
ORIGIN      
        1 meapeyldld eidfsddisy svtslktipa lcrrcdsqne drsvsssgwn cgvstlitnp
       61 qkptgiadvy skfrpvkrvs plkhqpetle nnenedqknn tveyqkgget dqgpqpeels
      121 pedgvgglpg kgsepsqalg elehydldmd eildvpyiks sqqlapltkv tsekrilglc
      181 ttinglsakt cpiastenst pnmtpfcvls pvksphlrka ptalrdqhkl stedsesspa
      241 lgkcgpayes enhskdflnk vfsdphsrki eksgpdcklr sfhlqssaag akteepingm
      301 nwtntqgtee rteylkkvrs ilnivnegqi sllphlaadn ldkihdengn nllhiaaskg
      361 haeclqhlts lmgedclner nteqltpagl aikngqlecv rwmvseteai aelscskdfp
      421 slihyagcyg qekillwllq fmqeqgisld evdregnsav hvasqhgylg ciqtlveyga
      481 nvtmqnhage kpsqsaerhg htlcsrylvv vetcmslasq vvkltkqlke qtvervtlqs
      541 qlqqlleaqk segkslpssp sspsspastk sqwkaldtde estgkskvga qegiqvlgsl
      601 svssrartkg kdedsdkilr qllgkeisen vctqeklsle fqdaqassrn skkiplekre
      661 lklarlrqlm qrslsesdtd snnsedpknt pvkradrprp qpivesvenv dsaeslhlmi
      721 kkhslasgrr fpfgmkasks ldghspspts essepdldsh gpglgmtppt qpsteatqss
      781 pdstaaqkva tspksalksp sskrrtsqns klrvtfeepv vqmeqtglel ngekdkdkgr
      841 apqrtsesge qmkrpfgtfr simeslsgnq nnnnnyqpas qlktctlplt slgrktadak
      901 gnpvspaskg knkaa
//
LOCUS       NP_001396809             923 aa            linear   ROD 27-AUG-2025
DEFINITION  BLOC-2 complex member HPS3 isoform 6 [Mus musculus].
ACCESSION   NP_001396809
VERSION     NP_001396809.1
DBSOURCE    REFSEQ: accession NM_001409880.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 923)
  AUTHORS   Wang,J.Y., Michki,S.N., Sitaraman,S., Banaschewski,B.J., Jamal,R.,
            Gokey,J.J., Lin,S.M., Katzen,J.B., Basil,M.C., Cantu,E.,
            Kropski,J.A., Zepp,J.A., Frank,D.B. and Young,L.R.
  TITLE     Dysregulated alveolar epithelial cell progenitor function and
            identity in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 10 (3), e183483 (2024)
   PUBMED   39699958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 923)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 923)
  AUTHORS   Kook,S., Qi,A., Wang,P., Meng,S., Gulleman,P., Young,L.R. and
            Guttentag,S.H.
  TITLE     Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak
            Syndromes
  JOURNAL   Am J Respir Cell Mol Biol 58 (5), 566-574 (2018)
   PUBMED   29190429
REFERENCE   4  (residues 1 to 923)
  AUTHORS   Young,L.R., Gulleman,P.M., Short,C.W., Tanjore,H., Sherrill,T.,
            Qi,A., McBride,A.P., Zaynagetdinov,R., Benjamin,J.T., Lawson,W.E.,
            Novitskiy,S.V. and Blackwell,T.S.
  TITLE     Epithelial-macrophage interactions determine pulmonary fibrosis
            susceptibility in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 1 (17), e88947 (2016)
   PUBMED   27777976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 923)
  AUTHORS   Li,K., Yang,L., Zhang,C., Niu,Y., Li,W. and Liu,J.J.
  TITLE     HPS6 interacts with dynactin p150Glued to mediate retrograde
            trafficking and maturation of lysosomes
  JOURNAL   J Cell Sci 127 (Pt 21), 4574-4588 (2014)
   PUBMED   25189619
REFERENCE   6  (residues 1 to 923)
  AUTHORS   McGarry,M.P., Reddington,M., Novak,E.K. and Swank,R.T.
  TITLE     Survival and lung pathology of mouse models of Hermansky-Pudlak
            syndrome and Chediak-Higashi syndrome
  JOURNAL   Proc Soc Exp Biol Med 220 (3), 162-168 (1999)
   PUBMED   10193444
REFERENCE   7  (residues 1 to 923)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   8  (residues 1 to 923)
  AUTHORS   Cornwell,M.M.
  TITLE     Molecular biology of P-glycoprotein
  JOURNAL   Cancer Treat Res 57, 37-56 (1991)
   PUBMED   1686722
  REMARK    Review article
REFERENCE   9  (residues 1 to 923)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   10 (residues 1 to 923)
  AUTHORS   Novak,E.K., Sweet,H.O., Prochazka,M., Parentis,M., Soble,R.,
            Reddington,M., Cairo,A. and Swank,R.T.
  TITLE     Cocoa: a new mouse model for platelet storage pool deficiency
  JOURNAL   Br J Haematol 69 (3), 371-378 (1988)
   PUBMED   3408670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079442.24.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.6396531.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.12 cM"
     Protein         1..923
                     /product="BLOC-2 complex member HPS3 isoform 6"
                     /note="hermansky-Pudlak syndrome 3 protein homolog; cocoa
                     protein; Hermansky-Pudlak syndrome 3 homolog; BLOC-2
                     complex member HPS3"
                     /calculated_mol_wt=104174
     Region          3..212
                     /region_name="HPS3_N"
                     /note="Hermansky-Pudlak syndrome 3; pfam14761"
                     /db_xref="CDD:464300"
     Region          218..239
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VB4.2)"
     Region          255..561
                     /region_name="HPS3_Mid"
                     /note="Hermansky-Pudlak syndrome 3, middle region;
                     pfam14762"
                     /db_xref="CDD:464301"
     Region          570..921
                     /region_name="HPS3_C"
                     /note="Hermansky-Pudlak syndrome 3, C-terminal; pfam14763"
                     /db_xref="CDD:464302"
     CDS             1..923
                     /gene="Hps3"
                     /gene_synonym="coa"
                     /coded_by="NM_001409880.1:46..2817"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:12807"
                     /db_xref="MGI:MGI:2153839"
ORIGIN      
        1 mvrlynlhpf gsqqvvpcqw epeqvccggs dalfvaagck veafavqgee lcrqrcafst
       61 lgrvlrmays eagdylvaie eknktiflra yvnwrskrsd nsrvcirmvg hnveasfces
      121 frdqmsiiem pmseaplcfs ccpvkgdllv gctnklvlft lkydiineef silnfersli
      181 ihidnitpve isfcvgyvav msdlevlllk lesdpihges vdhhpqetsn plkeaegvsn
      241 etsqlesedf viclkpmeli gekceqsgis vklestgled ekvkylrvrh llyrrfapdi
      301 ssyvlsdnik lhslqllpih qsgfhpdend lspkkempnl fcffslphvg ylymvvksve
      361 lmsvywypek sqqavltpqf lhvitssrkd asvrsgtphv aeaawnlylv nttapvqlyk
      421 emvdysnsyk tvktesclhl lseahllvra almdgsqlep aekaelleaf kescghlgdc
      481 ysrltteqsh lalpyykmsg lslaevlarv dwteesesqk yerglvfyin hslyenldee
      541 lskelaakva qifhmaepkq lphvlsspsm knidpltalh ylrkldscgv spvlvtltka
      601 avalkmgdld myrnemkshs emklvygfil eprlliqqwk gqivptelai dlketqpgll
      661 vasvlglqkn dkigivetds ffkvlcgkde davpqllidf weaqlvaclp nvvleelffk
      721 lisqyvwrls errcpdtvpl rtaedlinac shyglvnpwv hvlttsdsla dknytddllk
      781 lqslicspsl dvasiipfle plsedtvagl sthalchtrl qeyeqcidtl lercpeavia
      841 yanqelkedh wilwwkkllp elcqrvksgg ershlhlsll ketlsviavg ldlrdflnvl
      901 pedgaaaffl pyllfcsrkk slt
//
LOCUS       NP_001415446            1426 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 2 isoform 1 [Mus musculus].
ACCESSION   NP_001415446 XP_036020667
VERSION     NP_001415446.1
DBSOURCE    REFSEQ: accession NM_001428517.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1426)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1426)
  AUTHORS   Iulianella,A., Vanden Heuvel,G. and Trainor,P.
  TITLE     Dynamic expression of murine Cux2 in craniofacial, limb, urogenital
            and neuronal primordia
  JOURNAL   Gene Expr Patterns 3 (5), 571-577 (2003)
   PUBMED   12971989
REFERENCE   7  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Quaggin,S.E. and Igarashi,P.
  TITLE     A unique variant of a homeobox gene related to Drosophila cut is
            expressed in mouse testis
  JOURNAL   Biol Reprod 55 (4), 731-739 (1996)
   PUBMED   8879483
REFERENCE   8  (residues 1 to 1426)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Bodmer,R., McConnell,K.R., Nagami,G.T. and
            Igarashi,P.
  TITLE     Expression of a cut-related homeobox gene in developing and
            polycystic mouse kidney
  JOURNAL   Kidney Int 50 (2), 453-461 (1996)
   PUBMED   8840273
REFERENCE   10 (residues 1 to 1426)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124189.3 and AC113302.13.
            
            On Mar 14, 2024 this sequence version replaced XP_036020667.1.
            
            Summary: This gene is a member of the Cut family of transcription
            factors that have multiple DNA binding domains and regulate cell
            proliferation and differentiation. This gene is primarily expressed
            in nervous tissues where it controls the proliferation of neuronal
            precursors, and may play a role in organogenesis earlier during
            embryonic development. Mice lacking the encoded protein exhibit
            smaller spinal cords with deficits in neural progenitor development
            as well as in neuroblast and interneuron differentiation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.43006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.02 cM"
     Protein         1..1426
                     /product="homeobox protein cut-like 2 isoform 1"
                     /note="homeobox protein cut-like 2; homeobox protein
                     Cux-2"
                     /calculated_mol_wt=154533
     Region          77..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14529; propagated from
                     UniProtKB/Swiss-Prot (P70298.2)"
     Region          <116..>316
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          351..419
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          460..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          487..563
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          599..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          653..676
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          743..769
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          833..906
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          904..977
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          988..1064
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1114..1170
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1177..1392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     CDS             1..1426
                     /gene="Cux2"
                     /gene_synonym="1700051K22Rik; Cutl2; Cux-2"
                     /coded_by="NM_001428517.1:256..4536"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="GeneID:13048"
                     /db_xref="MGI:MGI:107321"
ORIGIN      
        1 mvapvlksfq aevvalskrs reaeaaflsv ykqlieapdp vpsfevartl ddrlqrpsfd
       61 psgqrlqdvh iawkrcpepp sareqnegtc ptghtpangn hlpgpedtlv tdtllqknea
      121 erqkglqevh itlaarlgea eekikvlhsa lkatqtelle lrrkydeeaa skadevglim
      181 tnlekanqra eaaqrevesl reqlasvnss irlaccspqg psgekvsfal csgprleaal
      241 askdreilrl lkdaqqlrhs lqeleevsan qiadlerqla akseaieklq ekleaqadye
      301 eiktelsilr amklasstcs lpqtlakpdd pllvakdvff ptqkfllekp allaspeedp
      361 seddsikgsl gteppyppql ppppgpedpl spspaqpllg pslgpdgprt fslspfpsla
      421 pgerlagdsl lskhmmgpaa fkgetgnlla fpptfyggak ppsapaasvp cpeptgapea
      481 vdgagpeeeq ldtaeiafqv keqllkhnig qrvfghyvlg lsqgsvseil arpkpwrklt
      541 vkgkepfikm kqflsdeqnv lalrtiqvrq rgsitprirt petgsddaik sileqakkei
      601 esqkggeskn spasvsipng tassstseda iknileqarr emqaqqqall emesgprgrs
      661 vppspperps patasqngal tcvkqedggg gsgssstvqa plavlspaaf vqriirkvks
      721 eigdagyfdh hwasdrglls rpyasvspsl sssssysgqp ngrawprgde atiapedeaa
      781 mgedeaprvg elkaeagape vgggrlpyyp ayvprtlkpt vppltpeqye lymyrevdtl
      841 eltrqvkekl akngicqrif gekvlglsqg svsdmlsrpk pwskltqkgr epfirmqlwl
      901 sdqlgqgqgq aptqqpsasq aspteptssp spppsptepe ktsqeplgls lesskenqqp
      961 egrassslgg kpfsssqaag giqemvamsp eldtysitkr vkevltdnnl gqrlfgesil
     1021 gltqgsvsdl lsrpkpwhkl slkgrepfvr mqlwlsdphn veklrdmkkl ekkaylkrry
     1081 gligtgsdse spaahsecps pclqpqelsl mqakkprvvl apaekealrk ayqlepypsq
     1141 qtiellsfql nlktntvinw fhnyrsrmrr emlvegtqdd pdfdpsggpn vltpghthre
     1201 ptpqspdset edqkppmksl elqepegplq raapdralvk ikqeeglevd gdsqpqdvgd
     1261 pdrgqdgpke ehthplgnsd lselapgpfl sgtpnpdcps lhnpqekgtg eqvhseplsf
     1321 kstsessccs legppnspsv isspdlttcv spapsssapi spslpgappa kvpstsptgd
     1381 taaalhpstk vnpnlqrrhe kmanlnsiiy rleraanree vlewef
//
LOCUS       NP_032702                988 aa            linear   ROD 27-AUG-2025
DEFINITION  next to BRCA1 gene 1 protein isoform 1 [Mus musculus].
ACCESSION   NP_032702
VERSION     NP_032702.1
DBSOURCE    REFSEQ: accession NM_008676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 988)
  AUTHORS   Nishimura,S., Linares,J.F., L'Hermitte,A., Duran,A., Cid-Diaz,T.,
            Martinez-Ordonez,A., Ruiz-Martinez,M., Kudo,Y., Marzio,A.,
            Heikenwalder,M., Roberts,L.R., Diaz-Meco,M.T. and Moscat,J.
  TITLE     Opposing regulation of the STING pathway in hepatic stellate cells
            by NBR1 and p62 determines the progression of hepatocellular
            carcinoma
  JOURNAL   Mol Cell 84 (23), 4660-4676 (2024)
   PUBMED   39423823
REFERENCE   2  (residues 1 to 988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 988)
  AUTHORS   Trapannone,R., Romanov,J. and Martens,S.
  TITLE     p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs
            and ESC-derived neurons
  JOURNAL   Life Sci Alliance 6 (11), e202301936 (2023)
   PUBMED   37620146
  REMARK    GeneRIF: p62 and NBR1 functions are dispensable for aggrephagy in
            mouse ESCs and ESC-derived neurons.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 988)
  AUTHORS   Merkley,S.D., Goodfellow,S.M., Guo,Y., Wilton,Z.E.R., Byrum,J.R.,
            Schwalm,K.C., Dinwiddie,D.L., Gullapalli,R.R., Deretic,V., Jimenez
            Hernandez,A., Bradfute,S.B., In,J.G. and Castillo,E.F.
  TITLE     Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of
            IL-12 Prevents Gut Dysbiosis and Inflammation
  JOURNAL   J Crohns Colitis 16 (2), 259-274 (2022)
   PUBMED   34374750
  REMARK    GeneRIF: Non-autophagy Role of Atg5 and NBR1 in Unconventional
            Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.
REFERENCE   5  (residues 1 to 988)
  AUTHORS   Huang,J., Linares,J.F., Duran,A., Xia,W., Saltiel,A.R.,
            Muller,T.D., Diaz-Meco,M.T. and Moscat,J.
  TITLE     NBR1 is a critical step in the repression of thermogenesis of
            p62-deficient adipocytes through PPARgamma
  JOURNAL   Nat Commun 12 (1), 2876 (2021)
   PUBMED   34001883
  REMARK    GeneRIF: NBR1 is a critical step in the repression of thermogenesis
            of p62-deficient adipocytes through PPARgamma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 988)
  AUTHORS   Dimitrov,S., Brennerova,M. and Forejt,J.
  TITLE     Expression profiles and intergenic structure of head-to-head
            oriented Brca1 and Nbr1 genes
  JOURNAL   Gene 262 (1-2), 89-98 (2001)
   PUBMED   11179671
REFERENCE   7  (residues 1 to 988)
  AUTHORS   Pershouse,M., Li,J., Yang,C., Su,H., Brundage,E., Di,W.,
            Biggs,P.J., Bradley,A. and Chinault,A.C.
  TITLE     BAC contig from a 3-cM region of mouse chromosome 11 surrounding
            Brca1
  JOURNAL   Genomics 69 (1), 139-142 (2000)
   PUBMED   11013085
REFERENCE   8  (residues 1 to 988)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (residues 1 to 988)
  AUTHORS   Bennett,L.M., Brownlee,H.A., Hagavik,S. and Wiseman,R.W.
  TITLE     Sequence analysis of the rat Brca1 homolog and its promoter region
  JOURNAL   Mamm Genome 10 (1), 19-25 (1999)
   PUBMED   9892727
REFERENCE   10 (residues 1 to 988)
  AUTHORS   Chambers,J.A. and Solomon,E.
  TITLE     Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene
  JOURNAL   Genomics 38 (3), 305-313 (1996)
   PUBMED   8975707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV558786.1, BC129867.1, BC052709.1 and CJ303949.1.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.202451.1, U73039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.36 cM"
     Protein         1..988
                     /product="next to BRCA1 gene 1 protein isoform 1"
                     /note="next to BRCA1 gene 1 protein; neighbor of BRCA1
                     gene 1 protein; membrane component chromosome 17 surface
                     marker 2 homolog; next to the Brca1"
                     /calculated_mol_wt=109827
     Region          5..86
                     /region_name="PB1_NBR1"
                     /note="The PB1 domain is an essential part of NBR1
                     protein, next to BRCA1, a scaffold protein mediating
                     specific protein-protein interaction with both titin
                     protein kinase and with another scaffold protein p62. A
                     canonical PB1-PB1 interaction, which involves...; cd06396"
                     /db_xref="CDD:99718"
     Site            order(50,52,54,63)
                     /site_type="other"
                     /note="PB1 interaction site [polypeptide binding]"
                     /db_xref="CDD:99718"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14596; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Region          126..150
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Region          216..260
                     /region_name="ZZ_NBR1_like"
                     /note="Zinc finger, ZZ type. Zinc finger present in
                     Drosophila ref(2)P, NBR1, Human sequestosome 1 and related
                     proteins. The ZZ motif coordinates two zinc ions and most
                     likely participates in ligand binding or molecular
                     scaffolding. Drosophila ref(2)P appears...; cd02340"
                     /db_xref="CDD:239080"
     Site            order(218,221,232,235,241,244,251,255)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239080"
     Site            order(218,221,241,244)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239080"
     Site            order(219,229,231,237,239)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239080"
     Site            order(230,257,260)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239080"
     Site            order(232,235,251,255)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239080"
     Region          370..480
                     /region_name="NBR1_like"
                     /note="Functionally uncharacterized domain in neighbor of
                     Brca1 Gene 1 and related proteins; cd14947"
                     /db_xref="CDD:271343"
     Region          543..637
                     /region_name="ATG8 family proteins-binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Site            587
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14596; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Site            591
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q501R9; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Site            597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q501R9; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Region          611..644
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Site            626
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14596; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Region          745..756
                     /region_name="ATG8 family proteins-binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Region          768..822
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Region          841..900
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97432.1)"
     Site            860
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q501R9; propagated from
                     UniProtKB/Swiss-Prot (P97432.1)"
     Region          938..976
                     /region_name="UBA_NBR1"
                     /note="UBA domain of next to BRCA1 gene 1 protein (NBR1)
                     and similar proteins; cd14319"
                     /db_xref="CDD:270504"
     CDS             1..988
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /coded_by="NM_008676.3:495..3461"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25475.1"
                     /db_xref="GeneID:17966"
                     /db_xref="MGI:MGI:108498"
ORIGIN      
        1 mepqvtlnvt fknetqsflv sdpenttwad veamvkvsfd lntiqikyld eeneeisins
       61 qgeyeealkm anikqgnqlq mqvhegyhvv dealpknvve nqaaartgkk plahysslvr
      121 vlgsdmktte epapeqcssa pcdtdqpqdk ppdwftsyle mfreqvvket vekleqrlqe
      181 klvlqkplls ssptevsmpi seetlflpen qfswhiacsh cqkrivgvry qcslcpsyni
      241 cedceagpyt hdtnhvllkl rrpvvissep ffyskysapr lpaaleqvrl qkqvdknfvk
      301 aekqrlraek kqrkaevkel kkqlklhrki hlwnsihglq spksplgrpe sllqsntlml
      361 plqpcapvmp tlsaafvden lpdgthlqpg tkfikhwrmk ntgnvkwntd tklkfmwgnl
      421 tlastekkdv lvpclkaghv gvvsvefiap tlegtytshw rlshkgqqfg prvwcsiivd
      481 pfpssespdn vegdrisssk addfsceqee afllaeeeip lgevtkqteg tgasasqktr
      541 raaserelyi psvdlltaqd llsfelldin ivqelervph ntpvdmtpcm splphdspli
      601 ekpglgqiqe esegagfkap pdstvsakrk aetpasveet eedlsgtqfv cetvirsltl
      661 daapdhnppc rqrspqrelq lystegqqpl vlpgfcrkds slkfalpeeg prgdereeiv
      721 hiveeevvee eeevqdeevq sqssassedy iiilpecfdt srplgdsmys salsqpgler
      781 gaegepgies gleptearer lperesqpqe qsisdiltts qpldtvplvp evaglpaals
      841 rsapcgqces sgvdspgvds patmhevppa pddirgeprg stglansrqr scdhsrhhng
      901 ssiagglvkg alsvaasayk alfsgppvta qpivsedqtt almahlfemg fcdrqlnlrl
      961 lrkhnynilq vvtellqvnn ndwyshry
//
LOCUS       NP_001123650             295 aa            linear   ROD 27-AUG-2025
DEFINITION  troponin T, cardiac muscle isoform d [Mus musculus].
ACCESSION   NP_001123650 NP_001129555
VERSION     NP_001123650.1
DBSOURCE    REFSEQ: accession NM_001130178.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 295)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 295)
  AUTHORS   Lin,S., Dieterich,C., Britto-Borges,T., Gunther,S., Kreher,S.,
            Eibach,Y., Kuenne,C., Schneider,A. and Braun,T.
  TITLE     Rbpms2 prevents major cardiac defects in cardiomyocyte-specific
            Rbpms-deficient mice
  JOURNAL   Dev Cell (2025) In press
   PUBMED   40602408
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 295)
  AUTHORS   Abukar,S., Embacher,P.A., Ciccarelli,A., Varsani-Brown,S.,
            North,I.G.W., Dean,J.A., Briscoe,J. and Ivanovitch,K.
  TITLE     Early coordination of cell migration and cardiac fate determination
            during mammalian gastrulation
  JOURNAL   EMBO J 44 (12), 3327-3359 (2025)
   PUBMED   40360834
REFERENCE   4  (residues 1 to 295)
  AUTHORS   Abraham,E., Kostina,A., Volmert,B., Roule,T., Huang,L., Yu,J.,
            Williams,A.E., Megill,E., Douglas,A., Pericak,O.M., Morris,A.,
            Stronati,E., Larrinaga-Zamanillo,A., Fueyo,R., Zubillaga,M.,
            Andrake,M.D., Akizu,N., Aguirre,A. and Estaras,C.
  TITLE     A retinoic acid:YAP1 signaling axis controls atrial lineage
            commitment
  JOURNAL   Cell Rep 44 (5), 115687 (2025)
   PUBMED   40343798
REFERENCE   5  (residues 1 to 295)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 295)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   7  (residues 1 to 295)
  AUTHORS   Tardiff,J.C., Factor,S.M., Tompkins,B.D., Hewett,T.E., Palmer,B.M.,
            Moore,R.L., Schwartz,S., Robbins,J. and Leinwand,L.A.
  TITLE     A truncated cardiac troponin T molecule in transgenic mice suggests
            multiple cellular mechanisms for familial hypertrophic
            cardiomyopathy
  JOURNAL   J Clin Invest 101 (12), 2800-2811 (1998)
   PUBMED   9637714
REFERENCE   8  (residues 1 to 295)
  AUTHORS   Jin,J.P., Wang,J. and Zhang,J.
  TITLE     Expression of cDNAs encoding mouse cardiac troponin T isoforms:
            characterization of a large sample of independent clones
  JOURNAL   Gene 168 (2), 217-221 (1996)
   PUBMED   8654947
REFERENCE   9  (residues 1 to 295)
  AUTHORS   Jin,J.P., Zhang,J. and Wang,J.
  TITLE     An embryonic alternative transcription initiation site and the
            5'-upstream structure of mouse cardiac troponin T gene
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1168-1174 (1995)
   PUBMED   7575526
REFERENCE   10 (residues 1 to 295)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162441.11, BQ554639.1 and AK169061.1.
            
            On Jun 16, 2012 this sequence version replaced NP_001129555.1.
            
            Transcript Variant: This variant (5) lacks an alternate in-frame
            exon in the 5' coding region, and includes an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The encoded
            isoform (d) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.32 cM"
     Protein         1..295
                     /product="troponin T, cardiac muscle isoform d"
                     /note="troponin T, cardiac muscle; tnTc; cardiac muscle
                     troponin T; cardiac TnT"
                     /calculated_mol_wt=34845
     Region          100..238
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..295
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /coded_by="NM_001130178.2:128..1015"
                     /note="isoform d is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS48376.1"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
ORIGIN      
        1 msdaeevvee yeeeqeeave eqeeaveeee aggaepepeg eaeteeanve evgpdeeakd
       61 aeegpvedtk pkpsrlfmpn lvppkipdge rvdfddihrk rvekdlnelq tlieahfenr
      121 kkeeeelisl kdriekrrae raeqqrirne rekerqnrla eerarreeee nrrkaedear
      181 kkkalsnmmh fggyiqkqaq terksgkrqt erekkkkila errkalaidh lnedqlreka
      241 kelwqsihnl eaekfdlqek fkqqkyeinv lrnrindnqk vsktrgkakv tgrwk
//
LOCUS       NP_034544               3120 aa            linear   ROD 27-AUG-2025
DEFINITION  huntingtin [Mus musculus].
ACCESSION   NP_034544 XP_132009
VERSION     NP_034544.1
DBSOURCE    REFSEQ: accession NM_010414.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 3120)
  AUTHORS   Burns,M.S., Miramontes,R., Wu,J., Gulia,R., Saddala,M.S., Lau,A.L.,
            Quach,T., Reidling,J.C., Swarup,V., La Spada,A.R., Lim,R.G. and
            Thompson,L.M.
  TITLE     Distinct molecular patterns in R6/2 HD mouse brain: Insights from
            spatiotemporal transcriptomics
  JOURNAL   Neuron 113 (15), 2416-2437 (2025)
   PUBMED   40482637
REFERENCE   2  (residues 1 to 3120)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell 188 (6), 1524-1544 (2025)
   PUBMED   39938516
REFERENCE   3  (residues 1 to 3120)
  AUTHORS   Barron,J.C., Dawson,L.J., Carew,S.J., Grace,M.C., Senior,K.A.,
            Ryan,K.C., Nafar,F., Moore,C.S., Blundell,J. and Parsons,M.P.
  TITLE     Huntingtin plays an essential role in the adult hippocampus
  JOURNAL   Neurobiol Dis 206, 106810 (2025)
   PUBMED   39855476
REFERENCE   4  (residues 1 to 3120)
  AUTHORS   Ramandi,D., Sepers,M.D., Wang,Z., Han,B., Woodard,C.L., Murphy,T.H.
            and Raymond,L.A.
  TITLE     Home cage-based insights into motor learning and strategy
            adaptation in a Huntington disease mouse model
  JOURNAL   PLoS One 20 (2), e0318663 (2025)
   PUBMED   39946413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 3120)
  AUTHORS   Brule,B., Alcala-Vida,R., Penaud,N., Scuto,J., Mounier,C.,
            Seguin,J., Khodaverdian,S.V., Cosquer,B., Birmele,E., Le Gras,S.,
            Decraene,C., Boutillier,A.L. and Merienne,K.
  TITLE     Accelerated epigenetic aging in Huntington's disease involves
            polycomb repressive complex 1
  JOURNAL   Nat Commun 16 (1), 1550 (2025)
   PUBMED   39934111
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 3120)
  AUTHORS   Lee,J., Park,E.H., Couture,G., Harvey,I., Garneau,P. and
            Pelletier,J.
  TITLE     An upstream open reading frame impedes translation of the
            huntingtin gene
  JOURNAL   Nucleic Acids Res 30 (23), 5110-5119 (2002)
   PUBMED   12466534
REFERENCE   7  (residues 1 to 3120)
  AUTHORS   Zeitlin,S., Liu,J.P., Chapman,D.L., Papaioannou,V.E. and
            Efstratiadis,A.
  TITLE     Increased apoptosis and early embryonic lethality in mice
            nullizygous for the Huntington's disease gene homologue
  JOURNAL   Nat Genet 11 (2), 155-163 (1995)
   PUBMED   7550343
REFERENCE   8  (residues 1 to 3120)
  AUTHORS   Duyao,M.P., Auerbach,A.B., Ryan,A., Persichetti,F., Barnes,G.T.,
            McNeil,S.M., Ge,P., Vonsattel,J.P., Gusella,J.F., Joyner,A.L. et
            al.
  TITLE     Inactivation of the mouse Huntington's disease gene homolog Hdh
  JOURNAL   Science 269 (5222), 407-410 (1995)
   PUBMED   7618107
REFERENCE   9  (residues 1 to 3120)
  AUTHORS   Trottier,Y., Devys,D., Imbert,G., Saudou,F., An,I., Lutz,Y.,
            Weber,C., Agid,Y., Hirsch,E.C. and Mandel,J.L.
  TITLE     Cellular localization of the Huntington's disease protein and
            discrimination of the normal and mutated form
  JOURNAL   Nat Genet 10 (1), 104-110 (1995)
   PUBMED   7647777
REFERENCE   10 (residues 1 to 3120)
  AUTHORS   Goldberg,Y.P., Lin,B.Y., Andrew,S.E., Nasir,J., Graham,R.,
            Glaves,M.L., Hutchinson,G., Theilmann,J., Ginzinger,D.G.,
            Schappert,K. et al.
  TITLE     Cloning and mapping of the alpha-adducin gene close to D4S95 and
            assessment of its relationship to Huntington disease
  JOURNAL   Hum Mol Genet 1 (9), 669-675 (1992)
   PUBMED   1284592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151669.5, AC133204.3 and BQ175932.1.
            
            On Mar 23, 2004 this sequence version replaced XP_132009.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24233.1, L28827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 12466534
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3120
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.92 cM"
     Protein         1..3120
                     /product="huntingtin"
                     /note="HD protein homolog; huntington disease protein
                     homolog; Huntington disease gene homolog"
                     /calculated_mol_wt=344659
     Site            9
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(125..126,129,132..133,164..165,168,171..172,175,
                     206..207,210,213..214,217,248..249,252,255..256)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          147..175
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            156
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          184..221
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          188..218
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            214
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          226..263
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          227..256
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            323
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            397
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            399
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            412
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            422
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          471..482
                     /region_name="Interaction with ZDHHC17.
                     /evidence=ECO:0000250|UniProtKB:P42858"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Site            491..492
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-3.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          496..559
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Site            508..509
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-3. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Site            530..531
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-3.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     mat_peptide     531..564
                     /product="Huntingtin, myristoylated N-terminal fragment.
                     /evidence=ECO:0000250|UniProtKB:P42858.
                     /id=PRO_0000447487"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
                     /calculated_mol_wt=3367
     Site            564..565
                     /site_type="cleavage"
                     /note="Cleavage, by caspase-6.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            621
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            624
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          783..820
                     /region_name="HEAT 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          883..921
                     /region_name="HEAT 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          1147..1205
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Site            1160
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Site            1180
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:P42858; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          1405..1442
                     /region_name="HEAT 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          1494..1534
                     /region_name="DUF3652"
                     /note="Huntingtin protein region; pfam12372"
                     /db_xref="CDD:463554"
     Site            1854
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42859.2)"
     Region          2373..2382
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     Region          2611..2638
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P42859.2)"
     CDS             1..3120
                     /gene="Htt"
                     /gene_synonym="C430023I11Rik; Hd; Hdh; IT15"
                     /coded_by="NM_010414.3:168..9530"
                     /db_xref="CCDS:CCDS19220.1"
                     /db_xref="GeneID:15194"
                     /db_xref="MGI:MGI:96067"
ORIGIN      
        1 matleklmka feslksfqqq qqqqpppqap pppppppppq ppqpppqgqp pppppplpgp
       61 aeeplhrpkk elsatkkdrv nhclticeni vaqslrnspe fqkllgiame lfllcsddae
      121 sdvrmvadec lnkvikalmd snlprlqlel ykeikkngap rslraalwrf aelahlvrpq
      181 kcrpylvnll pcltrtskrp eesvqetlaa avpkimasfg nfandneikv llkafianlk
      241 sssptvrrta agsavsicqh srrtqyfynw llnvllgllv pmeeehstll ilgvlltlrc
      301 lvpllqqqvk dtslkgsfgv trkemevsps teqlvqvyel tlhhtqhqdh nvvtgalell
      361 qqlfrtpppe llqalttpgg lgqltlvqee argrgrsgsi vellagggss cspvlsrkqk
      421 gkvllgeeea leddsesrsd vsssafaasv kseiggelaa ssgvstpgsv ghdiiteqpr
      481 sqhtlqadsv dlsgcdltsa atdgdeedil shsssqfsav psdpamdlnd gtqasspisd
      541 ssqtttegpd savtpsdsse ivldgadsqy lgmqigqpqe ddeegaagvl sgevsdvfrn
      601 sslalqqahl lermghsrqp sdssidkyvt rdevaeasdp eskpcrikgd igqpndddsa
      661 plvhcvrlls asflltgekk alvpdrdvrv svkalalsci gaavalhpes ffsrlykvpl
      721 nttesteeqy vsdilnyidh gdpqvrgata ilcgtlvysi lsrsrlrvgd wlgnirtltg
      781 ntfslvdcip llqktlkdes svtcklacta vrhcvlslcs ssysdlglql lidmlplkns
      841 sywlvrtell dtlaeidfrl vsfleakaes lhrgahhytg flklqervln nvviyllgde
      901 dprvrhvaat sltrlvpklf ykcdqgqadp vvavardqss vylkllmhet qppshfsvst
      961 itriyrgysl lpsitdvtme nnlsrvvaav shelitsttr altfgcceal cllsaafpvc
     1021 twslgwhcgv pplsasdesr ksctvgmasm iltllssawf pldlsahqda lilagnllaa
     1081 sapkslrssw tseeeansaa trqeeiwpal gdrtlvplve qlfshllkvi nicahvlddv
     1141 tpgpaikaal psltnppsls pirrkgkeke pgeqastpms pkkvgeasaa srqsdtsgpv
     1201 taskssslgs fyhlpsylkl hdvlkathan ykvtldlqns tekfggflrs aldvlsqile
     1261 latlqdigkc veevlgylks cfsrepmmat vcvqqllktl fgtnlasqfd glssnpsksq
     1321 craqrlgsss vrpglyhycf mapythftqa ladaslrnmv qaeqerdasg wfdvlqkvsa
     1381 qlktnltsvt knradknaih nhirlfeplv ikalkqyttt tsvqlqkqvl dllaqlvqlr
     1441 vnyclldsdq vfigfvlkqf eyievgqfre seaiipniff flvllsyery hskqiigipk
     1501 iiqlcdgima sgrkavthai palqpivhdl fvlrgtnkad agkeletqke vvvsmllrli
     1561 qyhqvlemfi lvlqqchken edkwkrlsrq vadiilpmla kqqmhidshe algvlntlfe
     1621 ilapsslrpv dmllrsmfit pstmasvstv qlwisgilai lrvlisqste divlcriqel
     1681 sfsphllscp vinrlrgggg nvtlgecseg kqkslpedtf srfllqlvgi lledivtkql
     1741 kvdmseqqht fycqelgtll mclihifksg mfrritaaat rlftsdgceg sfytleslna
     1801 rvrsmvpthp alvllwcqil llinhtdhrw waevqqtpkr hslsctksln pqksgeeeds
     1861 gsaaqlgmcn reivrrgali lfcdyvcqnl hdsehltwli vnhiqdlisl sheppvqdfi
     1921 saihrnsaas glfiqaiqsr cenlstpttl kktlqclegi hlsqsgavlt lyvdrllgtp
     1981 fralarmvdt lacrrvemll aanlqssmaq lpeeelnriq ehlqnsglaq rhqrlyslld
     2041 rfrlstvqds lsplppvtsh pldgdghtsl etvspdkdwy lqlvrsqcwt rsdsallega
     2101 elvnripaed mndfmmssef nlsllapcls lgmseiangq ksplfeaarg vilnrvtsvv
     2161 qqlpavhqvf qpflpiepta ywnklndllg dttsyqslti laralaqylv vlskvpahlh
     2221 lppekegdtv kfvvmtveal swhliheqip lsldlqagld ccclalqvpg lwgvlsspey
     2281 vthacslihc vrfileaiav qpgdqllgpe srshtpravr keevdsdiqn lshvtsacem
     2341 vadmveslqs vlalghkrns tlpsfltavl knivislarl plvnsytrvp plvwklgwsp
     2401 kpggdfgtvf peipveflqe keilkefiyr intlgwtnrt qfeetwatll gvlvtqplvm
     2461 eqeesppeed tertqihvla vqaitslvls amtvpvagnp avscleqqpr nkplkaldtr
     2521 fgrklsmirg iveqeiqemv sqrentathh shqawdpvps llpattgali shdklllqin
     2581 perepgnmsy klgqvsihsv wlgnnitplr eeewdeeeee esdvpaptsp pvspvnsrkh
     2641 ragvdihscs qfllelysrw ilpssaarrt pvilisevvr sllvvsdlft ertqfemmyl
     2701 tltelrrvhp sedeiliqyl vpatckaaav lgmdktvaep vsrllestlr sshlpsqiga
     2761 lhgilyvlec dllddtakql ipvvsdylls nlkgiahcvn ihsqqhvlvm catafylmen
     2821 ypldvgpefs asviqmcgvm lsgseestps iiyhcalrgl erlllseqls rldteslvkl
     2881 svdrvnvqsp hramaalglm ltcmytgkek aspgrasdps patpdsesvi vamervsvlf
     2941 drirkgfpce arvvarilpq flddffppqd vmnkvigefl snqqpypqfm atvvykvfqt
     3001 lhsagqssmv rdwvmlslsn ftqrtpvama mwslscflvs astspwvsai lphvisrmgk
     3061 leqvdvnlfc lvatdfyrhq ieeefdrraf qsvfevvaap gspyhrllac lqnvhkvttc
//
LOCUS       NP_001396812             773 aa            linear   ROD 27-AUG-2025
DEFINITION  BLOC-2 complex member HPS3 isoform 9 [Mus musculus].
ACCESSION   NP_001396812
VERSION     NP_001396812.1
DBSOURCE    REFSEQ: accession NM_001409883.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 773)
  AUTHORS   Wang,J.Y., Michki,S.N., Sitaraman,S., Banaschewski,B.J., Jamal,R.,
            Gokey,J.J., Lin,S.M., Katzen,J.B., Basil,M.C., Cantu,E.,
            Kropski,J.A., Zepp,J.A., Frank,D.B. and Young,L.R.
  TITLE     Dysregulated alveolar epithelial cell progenitor function and
            identity in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 10 (3), e183483 (2024)
   PUBMED   39699958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 773)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 773)
  AUTHORS   Kook,S., Qi,A., Wang,P., Meng,S., Gulleman,P., Young,L.R. and
            Guttentag,S.H.
  TITLE     Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak
            Syndromes
  JOURNAL   Am J Respir Cell Mol Biol 58 (5), 566-574 (2018)
   PUBMED   29190429
REFERENCE   4  (residues 1 to 773)
  AUTHORS   Young,L.R., Gulleman,P.M., Short,C.W., Tanjore,H., Sherrill,T.,
            Qi,A., McBride,A.P., Zaynagetdinov,R., Benjamin,J.T., Lawson,W.E.,
            Novitskiy,S.V. and Blackwell,T.S.
  TITLE     Epithelial-macrophage interactions determine pulmonary fibrosis
            susceptibility in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 1 (17), e88947 (2016)
   PUBMED   27777976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 773)
  AUTHORS   Li,K., Yang,L., Zhang,C., Niu,Y., Li,W. and Liu,J.J.
  TITLE     HPS6 interacts with dynactin p150Glued to mediate retrograde
            trafficking and maturation of lysosomes
  JOURNAL   J Cell Sci 127 (Pt 21), 4574-4588 (2014)
   PUBMED   25189619
REFERENCE   6  (residues 1 to 773)
  AUTHORS   McGarry,M.P., Reddington,M., Novak,E.K. and Swank,R.T.
  TITLE     Survival and lung pathology of mouse models of Hermansky-Pudlak
            syndrome and Chediak-Higashi syndrome
  JOURNAL   Proc Soc Exp Biol Med 220 (3), 162-168 (1999)
   PUBMED   10193444
REFERENCE   7  (residues 1 to 773)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   8  (residues 1 to 773)
  AUTHORS   Cornwell,M.M.
  TITLE     Molecular biology of P-glycoprotein
  JOURNAL   Cancer Treat Res 57, 37-56 (1991)
   PUBMED   1686722
  REMARK    Review article
REFERENCE   9  (residues 1 to 773)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   10 (residues 1 to 773)
  AUTHORS   Novak,E.K., Sweet,H.O., Prochazka,M., Parentis,M., Soble,R.,
            Reddington,M., Cairo,A. and Swank,R.T.
  TITLE     Cocoa: a new mouse model for platelet storage pool deficiency
  JOURNAL   Br J Haematol 69 (3), 371-378 (1988)
   PUBMED   3408670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079442.24.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.990812.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.12 cM"
     Protein         1..773
                     /product="BLOC-2 complex member HPS3 isoform 9"
                     /note="hermansky-Pudlak syndrome 3 protein homolog; cocoa
                     protein; Hermansky-Pudlak syndrome 3 homolog; BLOC-2
                     complex member HPS3"
                     /calculated_mol_wt=87423
     Region          1..411
                     /region_name="HPS3_Mid"
                     /note="Hermansky-Pudlak syndrome 3, middle region;
                     pfam14762"
                     /db_xref="CDD:464301"
     Region          420..771
                     /region_name="HPS3_C"
                     /note="Hermansky-Pudlak syndrome 3, C-terminal; pfam14763"
                     /db_xref="CDD:464302"
     CDS             1..773
                     /gene="Hps3"
                     /gene_synonym="coa"
                     /coded_by="NM_001409883.1:665..2986"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /db_xref="GeneID:12807"
                     /db_xref="MGI:MGI:2153839"
ORIGIN      
        1 meligekceq sgisvklest gledekvkyl rvrhllyrrf apdissyvls dniklhslql
       61 lpihqsgfhp dendlspkke mpnlfcffsl phvgylymvv ksvelmsvyw ypeksqqavl
      121 tpqflhvitr plhhhghgci vswlsltlls aylfflsqsl qcftvrcsaa vaheedlymd
      181 ttlkacppvs mdvcalriql figlkaichf knhiilltka epeaiperre spkklisrkd
      241 asvrsgtphv aeaawnlylv nttapvqlyk emvdysnsyk tvktesclhl lseahllvra
      301 almdgsqlep aekaelleaf kescghlgdc ysrltteqsh lalpyykmsg lslaevlarv
      361 dwteesesqk yerglvfyin hslyenldee lskelaakva qifhmaepkq lphvlsspsm
      421 knidpltalh ylrkldscgv spvlvtltka avalkmgdld myrnemkshs emklvygfil
      481 eprlliqqwk gqivptelai dlketqpgll vasvlglqkn dkigivetds ffkvlcgkde
      541 davpqllidf weaqlvaclp nvvleelffk lisqyvwrls errcpdtvpl rtaedlinac
      601 shyglvnpwv hvlttsdsla dknytddllk lqslicspsl dvasiipfle plsedtvagl
      661 sthalchtrl qeyeqcidtl lercpeavia yanqelkedh wilwwkkllp elcqrvksgg
      721 ershlhlsll ketlsviavg ldlrdflnvl pedgaaaffl pyllfcsrkk slt
//
LOCUS       NP_001350914             257 aa            linear   ROD 27-AUG-2025
DEFINITION  integrin alpha-X isoform 3 precursor [Mus musculus].
ACCESSION   NP_001350914
VERSION     NP_001350914.1
DBSOURCE    REFSEQ: accession NM_001363985.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 257)
  AUTHORS   Zhang,C., Chen,S., Wang,Z., Zhang,J., Yu,W., Wang,Y., Si,W.,
            Zhang,Y., Zhang,Y. and Liang,T.
  TITLE     Exploring the mechanism of intestinal bacterial translocation after
            severe acute pancreatitis: the role of Toll-like receptor 5
  JOURNAL   Gut Microbes 17 (1), 2489768 (2025)
   PUBMED   40243695
REFERENCE   2  (residues 1 to 257)
  AUTHORS   Wu,Z.Y., Wu,Q.W., Han,Y., Xiang,S.J., Wang,Y.N., Wu,W.W.,
            Chen,Y.X., Feng,Z.Q., Wang,Y.Y., Xu,Z.G., He,H.C., He,J.J.,
            Chen,J.Q., Sheng,H., Zhang,Q.H., Wang,Z.X., Liao,K., Zhao,Q.,
            Mei,W.J., Ding,P.R., Qiu,M.Z., Wang,F., Ju,H.Q., Luo,H.Y., Zhao,X.
            and Xu,R.H.
  TITLE     Alistipes finegoldii augments the efficacy of immunotherapy against
            solid tumors
  JOURNAL   Cancer Cell (2025) In press
   PUBMED   40712567
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 257)
  AUTHORS   Tatsumi,N., El-Fenej,J., Davila-Pagan,A. and Kumamoto,Y.
  TITLE     CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell
            differentiation
  JOURNAL   Nat Commun 16 (1), 2002 (2025)
   PUBMED   40011469
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 257)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 257)
  AUTHORS   Hu,Y., Wang,X., Zhao,Z., Liu,M., Ren,X., Xian,X., Liu,C. and
            Wang,Q.
  TITLE     The Downregulation of ITGAX Exacerbates Amyloid-beta Plaque
            Deposition in Alzheimer's Disease by Increasing Polarization of M1
            Microglia
  JOURNAL   J Alzheimers Dis 100 (2), 657-673 (2024)
   PUBMED   38905043
  REMARK    GeneRIF: The Downregulation of ITGAX Exacerbates Amyloid-beta
            Plaque Deposition in Alzheimer's Disease by Increasing Polarization
            of M1 Microglia.
REFERENCE   6  (residues 1 to 257)
  AUTHORS   Brocker,T., Riedinger,M. and Karjalainen,K.
  TITLE     Targeted expression of major histocompatibility complex (MHC) class
            II molecules demonstrates that dendritic cells can induce negative
            but not positive selection of thymocytes in vivo
  JOURNAL   J Exp Med 185 (3), 541-550 (1997)
   PUBMED   9053454
REFERENCE   7  (residues 1 to 257)
  AUTHORS   Huleatt,J.W. and Lefrancois,L.
  TITLE     Antigen-driven induction of CD11c on intestinal intraepithelial
            lymphocytes and CD8+ T cells in vivo
  JOURNAL   J Immunol 154 (11), 5684-5693 (1995)
   PUBMED   7751620
REFERENCE   8  (residues 1 to 257)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (residues 1 to 257)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
REFERENCE   10 (residues 1 to 257)
  AUTHORS   Metlay,J.P., Witmer-Pack,M.D., Agger,R., Crowley,M.T., Lawless,D.
            and Steinman,R.M.
  TITLE     The distinct leukocyte integrins of mouse spleen dendritic cells as
            identified with new hamster monoclonal antibodies
  JOURNAL   J Exp Med 171 (5), 1753-1771 (1990)
   PUBMED   2185332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124566.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.98 cM"
     Protein         1..257
                     /product="integrin alpha-X isoform 3 precursor"
                     /note="CD11C (p150) alpha polypeptide; complement receptor
                     4; CD11 antigen-like family member C; leukocyte adhesion
                     receptor p150,95; leukocyte adhesion glycoprotein p150,95
                     alpha chain; integrin aX"
                     /calculated_mol_wt=26467
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2075
     Region          151..>238
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     CDS             1..257
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /coded_by="NM_001363985.1:71..844"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS90336.1"
                     /db_xref="GeneID:16411"
                     /db_xref="MGI:MGI:96609"
ORIGIN      
        1 msctwiafll llgfvsclgf nldaeklthf hmdgaefghs vlqydsswvv vgapkeikat
       61 nqigglykcg yhtgncepis lqvppeavni slglslaaat npswllacgp tvhhtcreni
      121 yltglcflls ssfkqsqnfp taqqecpkqd qdivflidgs gsisstdfek mldfvkavms
      181 qlqrpstrfs lmqfsdyfrv hftfnnfist ssplsllgsv rqlrgytyta saikhvitvh
      241 hpkwssarch qgphchh
//
LOCUS       NP_031488               2842 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 3 [Mus musculus].
ACCESSION   NP_031488 XP_196187
VERSION     NP_031488.2
DBSOURCE    REFSEQ: accession NM_007462.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2842)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2842)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2842)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2842)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2842)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2842)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2842)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2842)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2842)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2842)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Jul 7, 2006 this sequence version replaced NP_031488.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an exon in the coding region, compared to variant 1. The
            encoded isoform (3) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080907.1, SRR7345562.4008403.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2842
                     /product="adenomatous polyposis coli protein isoform 3"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=310750
     Region          4..55
                     /region_name="APC_N_CC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     pfam16689"
                     /db_xref="CDD:435517"
     Region          125..205
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          338..390
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          391..464
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          457..508
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          463..506
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(497,501,505,540,544,548,584,588,592)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          510..551
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          514..551
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          558..593
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          601..642
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          647..687
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          651..685
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          689..729
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          693..729
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          730..1017
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          1034..1133
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1255..>1272
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1281..1367
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1635..1658
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1660..1713
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1714..1735
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1744..1837
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1871..1945
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          2032..2051
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2223..2568
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2670..2842
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2842
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_007462.4:396..8924"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS29125.1"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 maaasydqll kqvealkmen snlrqeledn snhltklete asnmkevlkq lqgsiedetm
       61 tsgqidller lkefnldsnf pgvklrskms lrsygsregs vssrsgecsp vpmgsfprrt
      121 fvngsrestg yleelekers llladldkee kekdwyyaql qnltkridsl pltenfslqt
      181 dmtrrqleye arqiraamee qlgtcqdmek raqrriariq qiekdilrvr qllqsqaaea
      241 erssqsrhda asheagrqhe ghgvaesnta asssgqspat rvdhetasvl sssgthsapr
      301 rltshlgtkv emvysllsml gthdkddmsr tllamsssqd scismrqsgc lplliqllhg
      361 ndkdsvllgn srgskearar asaalhniih sqpddkrgrr eirvlhlleq iraycetcwe
      421 wqeaheqgmd qdknpmpapv ehqicpavcv lmklsfdeeh rhamnelggl qaiaellqvd
      481 cemygltndh ysvtlrryag maltnltfgd vankatlcsm kgcmralvaq lksesedlqq
      541 viasvlrnls wradvnskkt lrevgsvkal mecalevkke stlksvlsal wnlsahcten
      601 kadicavdga laflvgtlty rsqtntlaii esgggilrnv ssliatnedh rqilrenncl
      661 qtllqhlksh sltivsnacg tlwnlsarnp kdqealwdmg avsmlknlih skhkmiamgs
      721 aaalrnlman rpakykdani mspgsslpsl hvrkqkalea eldaqhlset fdnidnlspk
      781 ashrskqrhk qnlygdyafd anrhddsrsd nfntgnmtvl spylnttvlp sssssrgsld
      841 ssrsekdrsl erergiglsa yhpttenagt sskrglqitt taaqiakvme evsaihtsqd
      901 drssasttef hcvaddrsaa rrssashths ntynftksen snrtcsmpya kveykrssnd
      961 slnsvtssdg ygkrgqmkps vesyseddes kfcsygqypa dlahkihsan hmddndgeld
     1021 tpinyslkys deqlnsgrqs psqnerwarp khviedeikq neqrqarsqn tsypvysent
     1081 ddkhlkfqph fgqqecvspy rsrgtsgset nrmgsshain qnvnqslcqe ddyeddkptn
     1141 yseryseeeq heeeeerptn ysikyneekh hvdqpidysl kyatdisssq kpsfsfskns
     1201 saqstkpehl spssentavp psnakrqnql rpssaqrngq tqkgttckvp sinqetiqty
     1261 cvedtpicfs rcsslsslss addeigcdqt tqeadsantl qtaevkendv trsaedpate
     1321 vpavsqnara kpsrlqasgl ssestrhnka vefssgaksp sksgaqtpks ppehyvqetp
     1381 lvfsrctsvs sldsfesrsi assvqsepcs gmvsgiisps dlpdspgqtm ppsrsktppp
     1441 ppqtvqakre vpkskvpaae kresgpkqta vnaavqrvqv lpdvdtllhf atestpdgfs
     1501 cssslsalsl depfiqkdve lrimppvqen dngneteseq peesnenqdk evekpdsekd
     1561 llddsddddi eileeciisa mptkssrkak klaqtasklp ppvarkpsql pvykllpaqn
     1621 rlqaqkhvsf tpgddvprvy cvegtpinfs tatslsdlti esppnelatg dgvragiqsg
     1681 efekrdtipt egrstddaqr gkissivtpd lddnkaeegd ilaecinsam pkgkshkpfr
     1741 vkkimdqvqq asstssgank nqvdtkkkkp tspvkpmpqn teyrtrvrkn tdskvnvnte
     1801 etfsdnkdsk kpslqtnaka fneklpnned rvrgsfalds phhytpiegt pycfsrndsl
     1861 ssldfddddv dlsrekaelr kgkeskdsea kvtcrpepns sqqaasksqa sikhpanraq
     1921 skpvlqkqpt fpqsskdgpd rgaatdeklq nfaientpvc fsrnsslssl sdidqennnn
     1981 kesepikeae pansqgepsk pqasgyapks fhvedtpvcf srnsslssls idseddllqe
     2041 cissampkkk rpsrlksese kqsprkvggi laedltldlk dlqrpdseha fspdsenfdw
     2101 kaiqegansi vsslhqaaaa aaclsrqass dsdsilslks gislgspfhl tpdqeekpft
     2161 snkgprilkp gekstleakk iesenkgikg gkkvykslit gkirsnseis sqmkqplptn
     2221 mpsisrgrtm ihipglrnss sstspvskkg pplktpasks psegpgatts prgtkpagks
     2281 elspitrqts qisgsnkgss rsgsrdstps rptqqplsrp mqspgrnsis pgrngisppn
     2341 klsqlprtss pstastkssg sgkmsytspg rqlsqqnltk qaslsknass iprsesaskg
     2401 lnqmsngngs nkkvelsrms stkssgsesd rserpalvrq stfikeapsp tlrrkleesa
     2461 sfeslspssr pdsptrsqaq tpvlspslpd mslsthpsvq aggwrklppn lsptieyndg
     2521 rptkrhdiar shsespsrlp inragtwkre hskhssslpr vstwrrtgss ssilsasses
     2581 sekakseder hvssmpaprq mkenqvptkg twrkikesdi sptgmasqsa ssgaasgaes
     2641 kpliyqmapp vsktedvwvr iedcpinnpr sgrsptgntp pvidsvsekg sssikdskdt
     2701 hgkqsvgsgs pvqtvgletr lnsfvqveap eqkgteakpg qsnpvsiaet aetciaertp
     2761 fsssssskhs spsgtvaarv tpfnynpspr kssadstsar psqiptpvst ntkkrdsktd
     2821 stessgaqsp krhsgsylvt sv
//
LOCUS       NP_001396752             704 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 6 [Mus musculus].
ACCESSION   NP_001396752 XP_030111011
VERSION     NP_001396752.1
DBSOURCE    REFSEQ: accession NM_001409823.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 704)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 704)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 704)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 704)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 704)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 704)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 704)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 704)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 704)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 704)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 22, 2022 this sequence version replaced XP_030111011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3550347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..704
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     6"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=80405
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          517..548
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          567..686
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(571,573..576,578,582,585,587,637..638,641,661,677)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(579..582,599,606,609..610,613,617,620..626,643..647,
                     655,682,684..685)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(581..582,615..616,619,621,623,636,643..647,684)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(581..582,615..616,619,621,623,636,643..646)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(599,606,609..610,613,617,622,624..626,655,682,
                     684..686)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..704
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409823.1:101..2215"
                     /note="isoform 6 is encoded by transcript variant 16"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhpfh
      301 atpntykrkn tetaldnkpc gpqcyqhleg akefaaalta eriktppkrp ggrrrgrlpn
      361 nssrpstpti svleskdtds dreagtetgg enndkeeeek kdetssssea nsrcqtpikm
      421 kpnieppenv ewsgaeasmf rvligtyydn fcaiarligt ktcrqvyefr vkessiiapv
      481 ptedvdtppr kkkrkhrlwa ahcrkiqlkk gqnrfpgcrc kaqcntkqcp cylavrecdp
      541 dlcltcgaad hwdsknvsck ncsiqrgskk hlllapsdva gwgifikdpv qknefiseyc
      601 geiisqdead rrgkvydkym csflfnlnnd fvvdatrkgn kirfanhsvn pncyakvmmv
      661 ngdhrigifa kraiqtgeel ffdyrysqad alkyvgiere meip
//
LOCUS       NP_001278167             678 aa            linear   ROD 27-AUG-2025
DEFINITION  protein CASP isoform e [Mus musculus].
ACCESSION   NP_001278167 XP_006504422
VERSION     NP_001278167.1
DBSOURCE    REFSEQ: accession NM_001291238.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 678)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 678)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 678)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 678)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 678)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 678)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 678)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 678)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 678)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 678)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Mar 29, 2014 this sequence version replaced XP_006504422.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014289.1, SRR13422603.377886.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..678
                     /product="protein CASP isoform e"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=77288
     Region          <111..>364
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          423..643
                     /region_name="CASP_C"
                     /note="CASP C terminal; pfam08172"
                     /db_xref="CDD:462392"
     Site            586
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13948; propagated from
                     UniProtKB/Swiss-Prot (P70403.2)"
     Site            620..640
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70403.2)"
     CDS             1..678
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_001291238.2:24..2060"
                     /note="isoform e is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS71685.1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 maanvgsmfq ywkrfdlqql qreldatatv lanrqdeseq srkrlieqsr efkkntpedl
       61 rkqvapllks fqgeidalsk rskeaeaafl tvykrlidvp dpvpaldvgq qleikvqrlh
      121 dietenqklr etleeynkef aevknqevti kalkekirey eqtlksqaet ialekeqklq
      181 ndfaekerkl qetqmsttsk leeaehklqt lqtalektrt elfdlktkyd eettakadei
      241 emimtdlera nqraevaqre aetlreqlss anhslqlasq iqkapdveqa ievltrssle
      301 velaakerei aqlvedvqrl qasltklren sasqisqleq qlnaknstlk qleeklkgqa
      361 dyeevkkeln tlksmefaps egagtqdstk plevlllekn rslqsenatl risnsdlsgr
      421 caelqihlte atakaveqke liarleqdls tiqsiqrpda egaseqglek ipepikeata
      481 lfygpsmsss gtlpegqvds llsiissqre rfrtrnqele aesrmaqhti qalqseldsl
      541 radniklfek ikflqsypgr gigsddtelr yssqyeerld pfssfskrer qrkylglspw
      601 dkatlgmgrl ilsnkmarti sffytlflhc lvflvlykla wsesverdca atcakkfadh
      661 lhkfhesdng aaagdlwq
//
LOCUS       NP_034500                260 aa            linear   ROD 27-AUG-2025
DEFINITION  granzyme A precursor [Mus musculus].
ACCESSION   NP_034500 XP_911853
VERSION     NP_034500.1
DBSOURCE    REFSEQ: accession NM_010370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 260)
  AUTHORS   Krstanovic,F., Mihalic,A., Rashidi,A.S., Sitnik,K.M., Ruzsics,Z.,
            Cicin-Sain,L., Verjans,G.M.G.M., Jonjic,S. and Brizic,I.
  TITLE     Neuron-restricted cytomegalovirus latency in the central nervous
            system regulated by CD4+ T-cells and IFN-gamma
  JOURNAL   J Neuroinflammation 22 (1), 95 (2025)
   PUBMED   40158177
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 260)
  AUTHORS   Kaur,G., Helmer,R.A., Martinez-Marin,D., Sennoune,S.R.,
            Washburn,R.L., Martinez-Zaguilan,R., Dufour,J.M. and Chilton,B.S.
  TITLE     Helicase-like transcription factor (Hltf)-deletion activates
            Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta
            cells resulting in neonatal lethality
  JOURNAL   PLoS One 18 (8), e0286109 (2023)
   PUBMED   37624843
  REMARK    GeneRIF: Helicase-like transcription factor (Hltf)-deletion
            activates Hmgb1-Rage axis and granzyme A-mediated killing of
            pancreatic beta cells resulting in neonatal lethality.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 260)
  AUTHORS   Calvo,J., Santiago,L., Arias,M., Pardo,J., Albareda,J.,
            Martinez-Lostao,L. and Garcia-Alvarez,F.
  TITLE     Granzyme-A deficiency attenuates experimental osteoarthritis in
            mice, but perforin deficiency does not
  JOURNAL   Jt Dis Relat Surg 34 (2), 271-278 (2023)
   PUBMED   37462629
  REMARK    GeneRIF: Granzyme-A deficiency attenuates experimental
            osteoarthritis in mice, but perforin deficiency does not.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 260)
  AUTHORS   Deliyanti,D., Figgett,W.A., Gebhardt,T., Trapani,J.A., Mackay,F.
            and Wilkinson-Berka,J.L.
  TITLE     CD8+ T Cells Promote Pathological Angiogenesis in Ocular
            Neovascular Disease
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (4), 522-536 (2023)
   PUBMED   36794587
REFERENCE   5  (residues 1 to 260)
  AUTHORS   Nagakubo,D., Hirakawa,M., Iwanami,N. and Boehm,T.
  TITLE     Limits to in vivo fate changes of epithelia in thymus and
            parathyroid by ectopic expression of transcription factors Gcm2 and
            Foxn1
  JOURNAL   Sci Rep 12 (1), 13554 (2022)
   PUBMED   35941210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 260)
  AUTHORS   Hershberger,R.J., Gershenfeld,H.K., Weissman,I.L. and Su,L.
  TITLE     Genomic organization of the mouse granzyme A gene. Two mRNAs encode
            the same mature granzyme A with different leader peptides
  JOURNAL   J Biol Chem 267 (35), 25488-25493 (1992)
   PUBMED   1460043
REFERENCE   7  (residues 1 to 260)
  AUTHORS   Douville,P., Seldin,M.F. and Carbonetto,S.
  TITLE     Genetic mapping of the integrin alpha 1 gene (Vla1) to mouse
            chromosome 13
  JOURNAL   Genomics 14 (2), 503-505 (1992)
   PUBMED   1427867
REFERENCE   8  (residues 1 to 260)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   9  (residues 1 to 260)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   10 (residues 1 to 260)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061146.1 and EH095037.1.
            
            On Dec 7, 2005 this sequence version replaced XP_911853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061146.1, X14799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     Protein         1..260
                     /product="granzyme A precursor"
                     /EC_number="3.4.21.78"
                     /note="H factor; fragmentin-1; t cell-specific serine
                     protease 1; autocrine thymic lymphoma granzyme-like serine
                     protease; BLT esterase; Hanukah factor; serine esterase 1"
                     /calculated_mol_wt=25933
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2684
     Region          28..252
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     mat_peptide     29..260
                     /product="Granzyme A. /id=PRO_0000027396"
                     /note="propagated from UniProtKB/Swiss-Prot (P11032.2)"
                     /calculated_mol_wt=25648
     Site            29
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(69,113,211)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            157
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11032.2)"
     Site            169
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11032.2)"
     Site            order(205,226,229)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..260
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /coded_by="NM_010370.3:31..813"
                     /db_xref="CCDS:CCDS26782.1"
                     /db_xref="GeneID:14938"
                     /db_xref="MGI:MGI:109266"
ORIGIN      
        1 mrnasgprgp slatllflll ipeggcerii ggdtvvphsr pymallklss nticagalie
       61 knwvltaahc nvgkrskfil gahsinkepe qqiltvkkaf pypcydeytr egdlqlvrlk
      121 kkatvnrnva ilhlpkkgdd vkpgtrcrva gwgrfgnksa psetlrevni tvidrkicnd
      181 ekhynfhpvi glnmicagdl rggkdscngd sgspllcdgi lrgitsfgge kcgdrrwpgv
      241 ytflsdkhln wikkimkgsv
//
LOCUS       NP_001415670            2909 aa            linear   ROD 27-AUG-2025
DEFINITION  pericentrin isoform c [Mus musculus].
ACCESSION   NP_001415670 XP_036011578
VERSION     NP_001415670.1
DBSOURCE    REFSEQ: accession NM_001428741.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2909)
  AUTHORS   Tran,L.N., Shinde,A., Schuster,K.H., Sabaawy,A., Dale,E.,
            Welch,M.J., Isner,T.J., Nunez,S.A., Garcia-Moreno,F.,
            Sagerstrom,C.G., Appel,B.H. and Franco,S.J.
  TITLE     Epigenetic priming of neural progenitors by Notch enhances Sonic
            hedgehog signaling and establishes gliogenic competence
  JOURNAL   Genes Dev 39 (13-14), 886-906 (2025)
   PUBMED   40404401
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2909)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   3  (residues 1 to 2909)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   4  (residues 1 to 2909)
  AUTHORS   He,Y., Wang,H., Hong,T., Hu,L., Gao,C., Gao,L., Cui,Y., Tan,R.,
            Pu,D. and Wu,J.
  TITLE     HFM1 is essential for the germ cell intercellular bridge transport
            in primordial follicle formation in mice
  JOURNAL   Cell Mol Life Sci 82 (1), 28 (2024)
   PUBMED   39725823
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2909)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   6  (residues 1 to 2909)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (residues 1 to 2909)
  AUTHORS   Feng,Y., Olson,E.C., Stukenberg,P.T., Flanagan,L.A., Kirschner,M.W.
            and Walsh,C.A.
  TITLE     LIS1 regulates CNS lamination by interacting with mNudE, a central
            component of the centrosome
  JOURNAL   Neuron 28 (3), 665-679 (2000)
   PUBMED   11163258
REFERENCE   8  (residues 1 to 2909)
  AUTHORS   Tong,J.K., Hassig,C.A., Schnitzler,G.R., Kingston,R.E. and
            Schreiber,S.L.
  TITLE     Chromatin deacetylation by an ATP-dependent nucleosome remodelling
            complex
  JOURNAL   Nature 395 (6705), 917-921 (1998)
   PUBMED   9804427
REFERENCE   9  (residues 1 to 2909)
  AUTHORS   Chen,H., Gos,A., Morris,M.A. and Antonarakis,S.E.
  TITLE     Localization of a human homolog of the mouse pericentrin gene
            (PCNT) to chromosome 21qter
  JOURNAL   Genomics 35 (3), 620-624 (1996)
   PUBMED   8812505
REFERENCE   10 (residues 1 to 2909)
  AUTHORS   Doxsey,S.J., Stein,P., Evans,L., Calarco,P.D. and Kirschner,M.
  TITLE     Pericentrin, a highly conserved centrosome protein involved in
            microtubule organization
  JOURNAL   Cell 76 (4), 639-650 (1994)
   PUBMED   8124707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158618.5 and AC141477.4.
            
            On Mar 22, 2024 this sequence version replaced XP_036011578.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.10369.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2909
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.8 cM"
     Protein         1..2909
                     /product="pericentrin isoform c"
                     /note="pericentrin 2; pericentrin-360; pericentrin-250"
                     /calculated_mol_wt=330439
     Region          1..117
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          <118..>584
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          429..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          510..1179
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            1022
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          <1084..>1672
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            1448
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          1756..1797
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          1812..1833
                     /region_name="Interaction with CDK5RAP2.
                     /evidence=ECO:0000269|PubMed:20471352"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          1826..1891
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Site            1839
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Site            1870
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Site            1871
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          1969..1990
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Site            1970
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Site            1998
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          2057..2099
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          <2083..>2308
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Site            2139
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     Region          <2213..>2502
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          2520..2543
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          2556..2821
                     /region_name="Interaction with NEK2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          2664..2695
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          2712..2790
                     /region_name="PACT_coil_coil"
                     /note="Pericentrin-AKAP-450 domain of centrosomal
                     targeting protein; pfam10495"
                     /db_xref="CDD:463115"
     Region          2769..2782
                     /region_name="Calmodulin-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Region          2798..2909
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48725.2)"
     Site            2876
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O95613; propagated from
                     UniProtKB/Swiss-Prot (P48725.2)"
     CDS             1..2909
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /coded_by="NM_001428741.1:154..8883"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="GeneID:18541"
                     /db_xref="MGI:MGI:102722"
ORIGIN      
        1 medeqeqrrr kveagrakla nfrqrktkgd cpnskkktak rkgsavhasv qeegsvatpn
       61 selpqggavf espscsntle gtrgasaaqe qedceldvtd lqgqqqtqpp ppqtahslel
      121 ealrlslnnm htaqleltqa nlqkeketal telremlngr raqelallqs rqqcelellr
      181 eqharekeem alrsgqeaae lkeklrseme knaqtietlk qdweserelc lenlrqelsl
      241 khqsemeglq sqfqkelseq kvelekifqa kheaevslkn leaqhqaaik klqedlqseh
      301 cqylqdleqk frekekakel eletlqasye dlkaqsqeei rllwsqlesm ktnreelngs
      361 wdpvlaqash leelehlrsg faqqqqqera qheselehlr vyfekklkda ektyqedltv
      421 fqqrlqeare dslesteiss scvlpeetsg regkeppdpl dlqlgqpkvq eslvedcqvk
      481 lskaeekiqq mkeefqkkea ewelsreelk reaeerlasm flelrekaes eklsiisrfe
      541 hressmrhlq dqqaaqildl erslmeqqgh lrqleqeltr ddllpcsqcg qepamaqeek
      601 ngallreked calqllmaqn rfleerkeim ekfakeqdaf lrdaqekhnh elqllqqghq
      661 qqllalrmel etkhrselte qlassesrrq allethvael qvkhnaeisa lekrhlsnld
      721 elescyvadv qtirdehqqa lellraelee qlqkkeschr emltqelenl krqhaeelqs
      781 vrdslrmems aqhiengkgp aadlqgahqq dpamalhneg hllvedgdav lrsvdaegll
      841 hqagpqelgd ahtvemqksq aelakpqelq asqdqvaqvr dkvfllnrel eecraeleql
      901 qqrrerenqe gttlicmlra dlelaqgegk alrdalrrll dlfgdtlkaa vtlksriser
      961 agllldheda adtsdarlaa aalgdmwsde glleidrtlp egaetssvce isshvcesff
     1021 ispentldce qpirrvyqsl stavegllem aldsskqlee arqlhrcver efrhrneema
     1081 qamqkqqell erlreesaak drlalelhta kgllegfkve kvdlqealgk keeseqqlil
     1141 eledlrkqlq qaarelltlk eeksvlwnqk etltneaker eagspvlpah kdtalqeeve
     1201 sltrvqwesr kqsekdratl lsqmrvlese ledqlvqhrg caqlaeevat lkqqlaaldk
     1261 hlrsqrqfmd dqaaereher eefqqeiqrl egqlrqaarp rppgprdsqc vqldeevell
     1321 qeklrekldg fnelvikkdf adqqlliqee eikrleetna siqrqmvqlq eelekqkksm
     1381 eelkekeilk qenmgdlllt tvsrsgldea gcpmlpqgss srgpeaqpdv terallqhen
     1441 evvhrrnsei delkslienl qenqrqlqkd kaeeieqlhe vieklqsels lmgpkvhevs
     1501 dpqagslhse laclrgeglg gqalrselqa aqaakevfgq lladqahghs qalealqqrl
     1561 qdaeevaarh laelehcval reaeveamas qiqefaatlk akeaiieqrd leidavnkwk
     1621 vshsleleai llalahfrha leqqtcatpd eppelrqlrv qcarlshqlq vlyrpflkcr
     1681 mqldqhqphv asigcanpca ddeleqegvs nrlalaphsl aaqakeeled cplgkanlma
     1741 qvrqlqeeld hrvhsvasrd tnsetcklqq pnlsengprn hccngeeskp sppddvlnia
     1801 kttwdvidii knqdllvqve mpdfptqekl tsqggpfssq asghsgsllp eeaaepqqdp
     1861 vraldlssws spevvrkdps lepqhslplt pgvgtvslhs vdispdwtdp llqadvsgll
     1921 cypgksasgq aplwavapsa gkhhaertat ekdvedfivt sfdsqellts pshelarrsd
     1981 gsrksdgpdi ammltlgseg setpttdlva aaaaavpfsr rfvqspgamk ekeihakqmk
     2041 allqmvfdes hqilalsesq dpssalnkge prdpldgfpr dsqalsevtt dkgekeslet
     2101 hltwseellr aiqevfareq ekaelqprpy gsnlgdynsl vqrlekviqe qgdpqkvqdh
     2161 lclsdrssll aeiqalraql rmthlqnqek lqqlcaalts teargsqreh qlrrqvella
     2221 ykveqekcia nelqktlske qetasdvrkr lvveqnavqd lkselhackq entsllesld
     2281 kvqqevlrlr avldgkekel kvvleelese rgkgqalqaq qeeqqlrylq regqssrale
     2341 elklslekql aqnnqlcval kheraakdnl qkelqieasr ceallaqekg qlselqksle
     2401 aersrslels ealqherllt eqlsrnsqea carqetqvqh allrklkaek traleleaml
     2461 ekvqkqaaht qqqleaqaqe rcvelrreke releiqrqrd ehkieqlqrl vrelrwkeev
     2521 sggngpcrgs pgrgslerdq fqeqqqelek irqqllcaag lltsftnhtv drtikdwtss
     2581 nekavsslmr tleelksels mptsfqkkmt aelqvqlmne llsdndaltk avgmatreka
     2641 elcrtvsrle ktlkhhtqkg cvlnrqskss lkqdgtdlqs slrhsdpewh sqttsgdtnt
     2701 cnikmeklyl hylraesfrk aliyqkkyll lliggfqdse qetlsmiahl gvfpskadkk
     2761 itmsrpftkf rtavrvviav lrlrflvkkw qevdrkgalv hpkstrhghr tsqrqrspsg
     2821 praslptrdt ssgptkasrh sprsaaagsp gkerststps srlersltas qdpehsltey
     2881 ihhlemiqqr lgglppdstq kschqkikq
//
LOCUS       NP_035057               1144 aa            linear   ROD 27-AUG-2025
DEFINITION  nitric oxide synthase, inducible isoform a [Mus musculus].
ACCESSION   NP_035057 XP_001001508
VERSION     NP_035057.1
DBSOURCE    REFSEQ: accession NM_010927.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1144)
  AUTHORS   Zhao,X., Li,J., Zhang,Y., Hu,L., Wu,D., Wu,J., Lyu,R., Li,P.,
            An,G., Cui,R., Sun,T., Zhu,P., Bai,L., Jiang,C. and Zhong,C.
  TITLE     Elevated nitric oxide during colitis restrains GM-CSF production in
            ILC3 cells via suppressing an AhR-Cyp4f13-NF-kappaB axis
  JOURNAL   Nat Commun 16 (1), 5654 (2025)
   PUBMED   40593752
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1144)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1144)
  AUTHORS   Mohanty,I., Fazelinia,H., Raimo,S., Ding,H., Spruce,L.,
            Symeonidou,M., Tenopoulou,M., Ichinose,F., Yamashita,H.,
            Shimokawa,H., Masato,T., Doulias,P.T. and Ischiropoulos,H.
  TITLE     Proteomic surveys of the mouse heart unveil cardiovascular
            responses to nitric oxide/cGMP signaling deficiencies
  JOURNAL   Commun Biol 8 (1), 817 (2025)
   PUBMED   40425728
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1144)
  AUTHORS   Ananth,M.R., Gardus,J.D., Huang,C., Palekar,N., Slifstein,M.,
            Zaborszky,L., Parsey,R.V., Talmage,D.A., DeLorenzo,C. and Role,L.W.
  TITLE     A central role for acetylcholine in entorhinal cortex function and
            dysfunction with age in humans and mice
  JOURNAL   Cell Rep 44 (2), 115249 (2025)
   PUBMED   39891909
REFERENCE   5  (residues 1 to 1144)
  AUTHORS   Ball,A.B., Jones,A.E., Nguyen,K.B., Rios,A., Marx,N., Hsieh,W.Y.,
            Yang,K., Desousa,B.R., Kim,K.K.O., Veliova,M., Del Mundo,Z.M.,
            Shirihai,O.S., Beninca,C., Stiles,L., Bensinger,S.J. and
            Divakaruni,A.S.
  TITLE     Pro-inflammatory macrophage activation does not require inhibition
            of oxidative phosphorylation
  JOURNAL   EMBO Rep 26 (4), 982-1002 (2025)
   PUBMED   39753784
REFERENCE   6  (residues 1 to 1144)
  AUTHORS   Stuehr,D.J. and Ikeda-Saito,M.
  TITLE     Spectral characterization of brain and macrophage nitric oxide
            synthases. Cytochrome P-450-like hemeproteins that contain a flavin
            semiquinone radical
  JOURNAL   J Biol Chem 267 (29), 20547-20550 (1992)
   PUBMED   1383204
REFERENCE   7  (residues 1 to 1144)
  AUTHORS   Lowenstein,C.J., Glatt,C.S., Bredt,D.S. and Snyder,S.H.
  TITLE     Cloned and expressed macrophage nitric oxide synthase contrasts
            with the brain enzyme
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6711-6715 (1992)
   PUBMED   1379716
REFERENCE   8  (residues 1 to 1144)
  AUTHORS   Xie,Q.W., Cho,H.J., Calaycay,J., Mumford,R.A., Swiderek,K.M.,
            Lee,T.D., Ding,A., Troso,T. and Nathan,C.
  TITLE     Cloning and characterization of inducible nitric oxide synthase
            from mouse macrophages
  JOURNAL   Science 256 (5054), 225-228 (1992)
   PUBMED   1373522
REFERENCE   9  (residues 1 to 1144)
  AUTHORS   Lyons,C.R., Orloff,G.J. and Cunningham,J.M.
  TITLE     Molecular cloning and functional expression of an inducible nitric
            oxide synthase from a murine macrophage cell line
  JOURNAL   J Biol Chem 267 (9), 6370-6374 (1992)
   PUBMED   1372907
REFERENCE   10 (residues 1 to 1144)
  AUTHORS   Liew,F.Y., Li,Y., Moss,D., Parkinson,C., Rogers,M.V. and Moncada,S.
  TITLE     Resistance to Leishmania major infection correlates with the
            induction of nitric oxide synthase in murine macrophages
  JOURNAL   Eur J Immunol 21 (12), 3009-3014 (1991)
   PUBMED   1721024
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M87039.1 and AL592185.35.
            
            On May 4, 2006 this sequence version replaced XP_001001508.1.
            
            Summary: Nitric oxide is a reactive free radical which acts as a
            biologic mediator in several processes, including neurotransmission
            and antimicrobial and antitumoral activities. This gene encodes a
            nitric oxide synthase that is inducible by a combination of
            lipopolysaccharide and certain cytokines. Three transcript variants
            encoding two different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87039.1, M84373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     Protein         1..1144
                     /product="nitric oxide synthase, inducible isoform a"
                     /EC_number="1.14.13.39"
                     /note="nitric oxide synthase, inducible; inducible nitric
                     oxide synthase; NOS type II; inducible NOS; macrophage
                     NOS; inducible NO synthase; peptidyl-cysteine
                     S-nitrosylase NOS2; nitric oxide synthase 2, inducible,
                     macrophage"
                     /calculated_mol_wt=130445
     Region          23..27
                     /region_name="DINNN-motif, mediates interaction with
                     SPSB1, SPSB2 and SPSB4.
                     /evidence=ECO:0000269|PubMed:20603330"
                     /note="propagated from UniProtKB/Swiss-Prot (P29477.1)"
     Region          37..59
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29477.1)"
     Region          78..490
                     /region_name="NOS_oxygenase_euk"
                     /note="Nitric oxide synthase (NOS) eukaryotic oxygenase
                     domain. NOS produces nitric oxide (NO) by catalyzing a
                     five-electron heme-based oxidation of a guanidine nitrogen
                     of L-arginine to L-citrulline via two successive
                     monooxygenation reactions producing N...; cd00795"
                     /db_xref="CDD:238410"
     Site            order(84..85,96,98,102,104..110,112,114,379,381,401,
                     406..407,411,417,430..431,461,463..465,471,473..477)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238410"
     Site            order(194,257,341,363..364,366..367,371,375..376,456..457,
                     485)
                     /site_type="active"
                     /db_xref="CDD:238410"
     Region          509..529
                     /region_name="Calmodulin-binding.
                     /evidence=ECO:0000250|UniProtKB:P35228"
                     /note="propagated from UniProtKB/Swiss-Prot (P29477.1)"
     Region          535..666
                     /region_name="Flavodoxin_1"
                     /note="pfam00258"
                     /db_xref="CDD:425562"
     Site            569
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q06518; propagated from
                     UniProtKB/Swiss-Prot (P29477.1)"
     Region          730..1126
                     /region_name="FNR_like"
                     /note="Ferredoxin reductase (FNR), an FAD and NAD(P)
                     binding protein, was intially identified as a chloroplast
                     reductase activity, catalyzing the electron transfer from
                     reduced iron-sulfur protein ferredoxin to NADP+ as the
                     final step in the electron transport...; cl06868"
                     /db_xref="CDD:447143"
     Site            order(766,900..903,918..920,936..939,978)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99799"
     Site            order(900,902..903)
                     /site_type="other"
                     /note="conserved FAD binding motif [chemical binding]"
                     /db_xref="CDD:99799"
     Site            order(936,939,942,948)
                     /site_type="other"
                     /note="phosphate binding motif [ion binding]"
                     /db_xref="CDD:99799"
     Site            order(973,977..980,982)
                     /site_type="other"
                     /note="beta-alpha-beta structure motif"
                     /db_xref="CDD:99799"
     Site            order(978..979,1009..1011,1077..1078)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99799"
     CDS             1..1144
                     /gene="Nos2"
                     /gene_synonym="i-NOS; iNOS; MAC-NOS; Nos-2; NOS-II; Nos2a"
                     /coded_by="NM_010927.4:256..3690"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25115.1"
                     /db_xref="GeneID:18126"
                     /db_xref="MGI:MGI:97361"
ORIGIN      
        1 macpwkflfk vksyqsdlke ekdinnnvkk tpcavlspti qddpkshqng spqlltgtaq
       61 nvpesldklh vtstrpqyvr iknwgsgeil hdtlhhkats dftckskscl gsimnpkslt
      121 rgprdkptpl eellphaief inqyygsfke akieehlarl eavtkeiett gtyqltldel
      181 ifatkmawrn aprcigriqw snlqvfdarn cstaqemfqh icrhilyatn ngnirsaitv
      241 fpqrsdgkhd frlwnsqlir yagyqmpdgt irgdaatlef tqlcidlgwk prygrfdvlp
      301 lvlqadgqdp evfeippdlv levtmehpky ewfqelglkw yalpavanml levgglefpa
      361 cpfngwymgt eigvrdfcdt qrynileevg rrmglethtl aslwkdravt einvavlhsf
      421 qkqnvtimdh htasesfmkh mqneyrargg cpadwiwlvp pvsgsitpvf hqemlnyvls
      481 pfyyyqiepw kthiwqnekl rprrreirfr vlvkvvffas mlmrkvmasr vratvlfate
      541 tgksealard latlfsyafn tkvvcmdqyk astleeeqll lvvtstfgng dcpsngqtlk
      601 kslfmlreln htfryavfgl gssmypqfca fahdidqkls hlgasqlapt gegdelsgqe
      661 dafrswavqt fraacetfdv rskhhiqipk rftsnatwep qqyrliqspe pldlnralss
      721 ihaknvftmr lksqqnlqse kssrttllvq ltfegsrgps ylpgehlgif pgnqtalvqg
      781 ilervvdcpt phqtvclevl desgsywvkd krlppcslsq altyflditt pptqlqlhkl
      841 arfatdetdr qrlealcqps eyndwkfsnn ptflevleef pslhvpaafl lsqlpilkpr
      901 yysisssqdh tpsevhltva vvtyrtrdgq gplhhgvcst wirnlkpqdp vpcfvrsvsg
      961 fqlpedpsqp ciligpgtgi apfrsfwqqr lhdsqhkglk ggrmslvfgc rhpeedhlyq
     1021 eemqemvrkr vlfqvhtgys rlpgkpkvyv qdilqkqlan evlsvlhgeq ghlyicgdvr
     1081 mardvattlk klvatklnls eeqvedyffq lksqkryhed ifgavfsyga kkgsaleepk
     1141 atrl
//
LOCUS       NP_035981                576 aa            linear   ROD 27-AUG-2025
DEFINITION  5'-nucleotidase preproprotein [Mus musculus].
ACCESSION   NP_035981
VERSION     NP_035981.1
DBSOURCE    REFSEQ: accession NM_011851.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 576)
  AUTHORS   Jin,H., Zhong,X., Zhang,C., Wu,Y., Sun,J., Wang,X., Wang,Z.,
            Zhu,J., Jiang,Y., Du,X., Zhang,Z., Zhang,D. and Sun,G.
  TITLE     CD73 promotes the immunoregulatory functions of hepatic Tregs
            through enzymatic and nonenzymatic pathways in MASLD development
  JOURNAL   Mol Metab 96, 102131 (2025)
   PUBMED   40139441
REFERENCE   2  (residues 1 to 576)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   3  (residues 1 to 576)
  AUTHORS   Fu,Z., Ganesana,M., Hwang,P., Tan,X., Kinkaid,M.M., Sun,Y.Y.,
            Bian,E., Weybright,A., Chen,H.R., Sol-Church,K., Eyo,U.B.,
            Pridans,C., Quintana,F.J., Robson,S.C., Kumar,P., Venton,B.J.,
            Schaefer,A. and Kuan,C.Y.
  TITLE     Microglia modulate the cerebrovascular reactivity through
            ectonucleotidase CD39
  JOURNAL   Nat Commun 16 (1), 956 (2025)
   PUBMED   39843911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 576)
  AUTHORS   Nettersheim,F.S., Brunel,S., Sinkovits,R.S., Armstrong,S.S.,
            Roy,P., Billitti,M., Kobiyama,K., Alimadadi,A., Bombin,S., Lu,L.,
            Zoccheddu,M., Oliaeimotlagh,M., Benedict,C.A., Sette,A. and Ley,K.
  TITLE     PD-1 and CD73 on naive CD4+ T cells synergistically limit responses
            to self
  JOURNAL   Nat Immunol 26 (1), 105-115 (2025)
   PUBMED   39572641
REFERENCE   5  (residues 1 to 576)
  AUTHORS   Eltzschig,H.K., Thompson,L.F., Karhausen,J., Cotta,R.J., Ibla,J.C.,
            Robson,S.C. and Colgan,S.P.
  TITLE     Endogenous adenosine produced during hypoxia attenuates neutrophil
            accumulation: coordination by extracellular nucleotide metabolism
  JOURNAL   Blood 104 (13), 3986-3992 (2004)
   PUBMED   15319286
REFERENCE   6  (residues 1 to 576)
  AUTHORS   Tsuji,Y., Kaburagi,Y., Terauchi,Y., Satoh,S., Kubota,N.,
            Tamemoto,H., Kraemer,F.B., Sekihara,H., Aizawa,S., Akanuma,Y.,
            Tobe,K., Kimura,S. and Kadowaki,T.
  TITLE     Subcellular localization of insulin receptor substrate family
            proteins associated with phosphatidylinositol 3-kinase activity and
            alterations in lipolysis in primary mouse adipocytes from IRS-1
            null mice
  JOURNAL   Diabetes 50 (6), 1455-1463 (2001)
   PUBMED   11375348
REFERENCE   7  (residues 1 to 576)
  AUTHORS   Braun,N., Brendel,P. and Zimmermann,H.
  TITLE     Distribution of 5'-nucleotidase in the developing mouse retina
  JOURNAL   Brain Res Dev Brain Res 88 (1), 79-86 (1995)
   PUBMED   7493409
REFERENCE   8  (residues 1 to 576)
  AUTHORS   Resta,R., Hooker,S.W., Hansen,K.R., Laurent,A.B., Park,J.L.,
            Blackburn,M.R., Knudsen,T.B. and Thompson,L.F.
  TITLE     Murine ecto-5'-nucleotidase (CD73): cDNA cloning and tissue
            distribution
  JOURNAL   Gene 133 (2), 171-177 (1993)
   PUBMED   8224905
REFERENCE   9  (residues 1 to 576)
  AUTHORS   Schoen,S.W. and Graybiel,A.M.
  TITLE     Species-specific patterns of glycoprotein expression in the
            developing rodent caudoputamen: association of 5'-nucleotidase
            activity with dopamine islands and striosomes in rat, but with
            extrastriosomal matrix in mouse
  JOURNAL   J Comp Neurol 333 (4), 578-596 (1993)
   PUBMED   8103780
REFERENCE   10 (residues 1 to 576)
  AUTHORS   Berkemeier,L.R., Winslow,J.W., Kaplan,D.R., Nikolics,K.,
            Goeddel,D.V. and Rosenthal,A.
  TITLE     Neurotrophin-5: a novel neurotrophic factor that activates trk and
            trkB
  JOURNAL   Neuron 7 (5), 857-866 (1991)
   PUBMED   1742028
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB850214.1 and AK029979.1.
            
            Summary: This gene encodes a membrane-bound nucleotidase that
            hydrolyzes extracellular nucleoside monophosphates. The encoded
            preproprotein undergoes proteolytic processing to generate to a
            functional, homodimeric enzyme that preferentially uses adenosine
            monophosphate as a substrate to generate free adenosine. Mice
            lacking the encoded protein exhibit a significantly reduced fall in
            stop flow pressure and superficial nephron glomerular filtration
            rate in response to a saturating increase of tubular perfusion
            flow. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029979.1, AK154614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     Protein         1..576
                     /product="5'-nucleotidase preproprotein"
                     /EC_number="3.1.3.5"
                     /EC_number="3.1.3.91"
                     /EC_number="3.1.3.89"
                     /EC_number="3.1.3.99"
                     /EC_number="3.1.3.35"
                     /note="5'-nucleotidase; ecto-5'-nucleotidase;
                     5'-deoxynucleotidase; thymidylate 5'-phosphatase;
                     IMP-specific 5'-nucleotidase"
                     /calculated_mol_wt=60911
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2972
     mat_peptide     29..551
                     /product="5'-nucleotidase. /id=PRO_0000000017"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61503.2)"
                     /calculated_mol_wt=58060
     Region          31..312
                     /region_name="MPP_CD73_N"
                     /note="CD73 ecto-5'-nucleotidase and related proteins,
                     N-terminal metallophosphatase domain; cd07409"
                     /db_xref="CDD:277354"
     Site            order(38,40,87,119..120,123,186,222,245,247)
                     /site_type="active"
                     /db_xref="CDD:277354"
     Site            order(38,40,87,119,222,245,247)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:277354"
     Site            55
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     Site            120
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P21589; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     Site            123
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P21589; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     Site            313
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     Site            335
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     Region          341..515
                     /region_name="5_nucleotid_C"
                     /note="5'-nucleotidase, C-terminal domain; pfam02872"
                     /db_xref="CDD:427027"
     Site            405
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61503.2)"
     CDS             1..576
                     /gene="Nt5e"
                     /gene_synonym="2210401F01Rik; 5'-NT; CD73; eNT; NT; Nt5"
                     /coded_by="NM_011851.4:78..1808"
                     /db_xref="CCDS:CCDS23386.1"
                     /db_xref="GeneID:23959"
                     /db_xref="MGI:MGI:99782"
ORIGIN      
        1 mrpaaakvpk wlllalsall pqwpaasawe ltilhtndvh srleqtsdds tkclnaslcv
       61 ggvarlftkv qqirkeepnv lfldagdqyq gtiwftvykg levahfmnil gydamalgnh
      121 efdngvegli dpllrnvkfp ilsanikarg plahqisglf lpskvlsvgg evvgivgyts
      181 ketpflsnpg tnlvfedeis alqpevdklk tlnvnkiial ghsgfemdkl iaqkvrgvdi
      241 vvgghsntfl ytgnppskev pagkypfivt addgrqvpvv qayafgkylg ylkvefddkg
      301 nvitsygnpi llnssipeda tikadinqwr ikldnystqe lgrtivyldg stqtcrfrec
      361 nmgnlicdam innnlrhpde mfwnhvsmci vngggirspi deknngtitw enlaavlpfg
      421 gtfdlvqlkg stlkkafehs vhrygqstge flqvggihvv ydinrkpwnr vvqlevlctk
      481 crvpiyeple mdkvykvtlp sylanggdgf qmikdellkh dsgdqdisvv seyiskmkvv
      541 ypavegrikf saashyqgsf plvilsfwam ililyq
//
LOCUS       NP_036035                784 aa            linear   ROD 27-AUG-2025
DEFINITION  toll-like receptor 2 precursor [Mus musculus].
ACCESSION   NP_036035
VERSION     NP_036035.3
DBSOURCE    REFSEQ: accession NM_011905.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 784)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 784)
  AUTHORS   Wu,Z.Y., Wu,Q.W., Han,Y., Xiang,S.J., Wang,Y.N., Wu,W.W.,
            Chen,Y.X., Feng,Z.Q., Wang,Y.Y., Xu,Z.G., He,H.C., He,J.J.,
            Chen,J.Q., Sheng,H., Zhang,Q.H., Wang,Z.X., Liao,K., Zhao,Q.,
            Mei,W.J., Ding,P.R., Qiu,M.Z., Wang,F., Ju,H.Q., Luo,H.Y., Zhao,X.
            and Xu,R.H.
  TITLE     Alistipes finegoldii augments the efficacy of immunotherapy against
            solid tumors
  JOURNAL   Cancer Cell (2025) In press
   PUBMED   40712567
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 784)
  AUTHORS   Wang,J., Gong,P., Liu,Q., Wang,M., Wu,D., Li,M., Zheng,S., Wang,H.
            and Long,Q.
  TITLE     Stimulation of regulatory dendritic cells suppresses cytotoxic T
            cell function and alleviates DEN-induced liver injury, fibrosis and
            hepatocellular carcinoma
  JOURNAL   Front Immunol 16, 1565486 (2025)
   PUBMED   40264769
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 784)
  AUTHORS   Cimini,M., Hansmann,U.H.E., Gonzalez,C., Chesney,A.D.,
            Truongcao,M.M., Gao,E., Wang,T., Roy,R., Forte,E., Mallaredy,V.,
            Thej,C., Magadum,A., Joladarashi,D., Benedict,C., Koch,W.J.,
            Tukel,C. and Kishore,R.
  TITLE     Podoplanin-positive cell-derived small extracellular vesicles
            contribute to cardiac amyloidosis after myocardial infarction
  JOURNAL   Cell Rep 44 (3), 115408 (2025)
   PUBMED   40056419
REFERENCE   5  (residues 1 to 784)
  AUTHORS   Senapati,S., Bertolini,T.B., Minnier,M.A., Yazicioglu,M.N.,
            Markusic,D.M., Zhang,R., Wicks,J., Nahvi,A., Herzog,R.W.,
            Walsh,M.C., Cejas,P.J. and Armour,S.M.
  TITLE     Inhibition of IFNAR-JAK signaling enhances tolerability and
            transgene expression of systemic non-viral DNA delivery
  JOURNAL   Mol Ther Nucleic Acids 36 (2), 102502 (2025)
   PUBMED   40206655
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 784)
  AUTHORS   Matsuguchi,T., Takagi,K., Musikacharoen,T. and Yoshikai,Y.
  TITLE     Gene expressions of lipopolysaccharide receptors, toll-like
            receptors 2 and 4, are differently regulated in mouse T lymphocytes
  JOURNAL   Blood 95 (4), 1378-1385 (2000)
   PUBMED   10666214
REFERENCE   7  (residues 1 to 784)
  AUTHORS   Underhill,D.M., Ozinsky,A., Hajjar,A.M., Stevens,A., Wilson,C.B.,
            Bassetti,M. and Aderem,A.
  TITLE     The Toll-like receptor 2 is recruited to macrophage phagosomes and
            discriminates between pathogens
  JOURNAL   Nature 401 (6755), 811-815 (1999)
   PUBMED   10548109
REFERENCE   8  (residues 1 to 784)
  AUTHORS   Takeuchi,O., Hoshino,K., Kawai,T., Sanjo,H., Takada,H., Ogawa,T.,
            Takeda,K. and Akira,S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   9  (residues 1 to 784)
  AUTHORS   Heine,H., Kirschning,C.J., Lien,E., Monks,B.G., Rothe,M. and
            Golenbock,D.T.
  TITLE     Cutting edge: cells that carry A null allele for toll-like receptor
            2 are capable of responding to endotoxin
  JOURNAL   J Immunol 162 (12), 6971-6975 (1999)
   PUBMED   10358136
REFERENCE   10 (residues 1 to 784)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005043.1, BY743020.1 and BP771904.1.
            
            On Oct 27, 2007 this sequence version replaced NP_036035.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014693.1, AK005043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 37.4 cM"
     Protein         1..784
                     /product="toll-like receptor 2 precursor"
                     /EC_number="3.2.2.6"
                     /calculated_mol_wt=86647
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2839
     mat_peptide     25..784
                     /product="Toll-like receptor 2. /id=PRO_0000034712"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
                     /calculated_mol_wt=86647
     Region          <43..295
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          54..77
                     /region_name="LRR 1.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          55..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          78..101
                     /region_name="LRR 2.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          102..125
                     /region_name="LRR 3.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          126..150
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          126..150
                     /region_name="LRR 4.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17889651,
                     ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:26283364;
                     propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          151..175
                     /region_name="LRR 5.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          176..202
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          176..199
                     /region_name="LRR 6.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          200..223
                     /region_name="LRR 7.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          203..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          224..250
                     /region_name="LRR 8.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          251..278
                     /region_name="LRR 9.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          279..308
                     /region_name="LRR 10.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          309..337
                     /region_name="LRR 11.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          <335..>555
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          338..361
                     /region_name="LRR 12.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Site            349
                     /site_type="other"
                     /note="Interaction with bacterial lipopeptide.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          362..388
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          362..388
                     /region_name="LRR 13.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          389..414
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          389..414
                     /region_name="LRR 14.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Site            414
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17889651,
                     ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:26283364;
                     propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          415..437
                     /region_name="LRR 15.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          438..458
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          438..457
                     /region_name="LRR 16.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Site            442
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17889651,
                     ECO:0000269|PubMed:19931471, ECO:0000269|PubMed:26283364;
                     propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          458..478
                     /region_name="LRR 17.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          459..478
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          479..500
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          479..500
                     /region_name="LRR 18.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          501..524
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          501..524
                     /region_name="LRR 19.
                     /evidence=ECO:0000269|PubMed:19931471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          533..586
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Site            588..608
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     Region          640..784
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     Region          761..778
                     /region_name="ATG16L1-binding motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN7.1)"
     CDS             1..784
                     /gene="Tlr2"
                     /gene_synonym="Ly105"
                     /coded_by="NM_011905.3:353..2707"
                     /db_xref="CCDS:CCDS17435.1"
                     /db_xref="GeneID:24088"
                     /db_xref="MGI:MGI:1346060"
ORIGIN      
        1 mlralwlfwi lvaitvlfsk rcsaqeslsc dasgvcdgrs rsftsipsgl taamksldls
       61 fnkityighg dlracanlqv lmlkssrint iegdafyslg slehldlsdn hlsslssswf
      121 gplsslkyln lmgnpyqtlg vtslfpnltn lqtlrignve tfseirridf agltslnele
      181 ikalslrnyq sqslksirdi hhltlhlses aflleifadi lssvrylelr dtnlarfqfs
      241 plpvdevssp mkklafrgsv ltdesfnell kllryilels evefddctln glgdfnpses
      301 dvvselgkve tvtirrlhip qfylfydlst vysllekvkr itvenskvfl vpcsfsqhlk
      361 slefldlsen lmveeylkns ackgawpslq tlvlsqnhlr smqktgeill tlknltsldi
      421 srntfhpmpd scqwpekmrf lnlsstgirv vktcipqtle vldvsnnnld sfslflprlq
      481 elyisrnklk tlpdaslfpv llvmkirena vstfskdqlg sfpkletlea gdnhfvcsce
      541 llsftmetpa laqilvdwpd sylcdspprl hghrlqdarp svlechqaal vsgvccalll
      601 lillvgalch hfhglwylrm mwawlqakrk pkkapcrdvc ydafvsyseq dshwvenlmv
      661 qqlensdppf klclhkrdfv pgkwiidnii dsiekshktv fvlsenfvrs ewckyeldfs
      721 hfrlfdennd aailvllepi erkaipqrfc klrkimntkt ylewpldegq qevfwvnlrt
      781 aiks
//
LOCUS       NP_032413                110 aa            linear   ROD 27-AUG-2025
DEFINITION  insulin-2 preproprotein [Mus musculus].
ACCESSION   NP_032413
VERSION     NP_032413.1
DBSOURCE    REFSEQ: accession NM_008387.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Brown,M.E., Miranda,V.E., Nevills,S., Hu,R., Dadi,P.K.,
            Simmons,A.J., Xu,Y., Yang,Y., Yagan,M., Najam,S., Sampson,L.L.,
            Magnuson,M.A., Jacobson,D.A., Lau,K.S., Hodges,E. and Gu,G.
  TITLE     Pancreatic islet beta-cell subtypes are derived from
            biochemically-distinct and nutritionally-regulated islet
            progenitors
  JOURNAL   Nat Commun 16 (1), 5758 (2025)
   PUBMED   40593675
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Spathies,J., Ratley,G., D'Souza,B.N., Sun,A.A., Gough,P.,
            Chaudhary,P.P., Matriz,J., Yadav,M., Zeldin,J., Freeman,A.F. and
            Myles,I.A.
  TITLE     Skin imaging mass spectrometry of controls versus atopic dermatitis
            patients with and without STAT3 mutations
  JOURNAL   iScience 28 (6), 112644 (2025)
   PUBMED   40510125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Panda,A.C., Kulkarni,S.D., Muralidharan,B., Bakthavachalu,B. and
            Seshadri,V.
  TITLE     Novel splice variant of mouse insulin2 mRNA: implications for
            insulin expression
  JOURNAL   FEBS Lett 584 (6), 1169-1173 (2010)
   PUBMED   20153322
  REMARK    GeneRIF: Alternative splicing of insulin mRNA in mice could result
            in an additional level of regulation in insulin biosynthesis.
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Minn,A.H., Lan,H., Rabaglia,M.E., Harlan,D.M., Peculis,B.A.,
            Attie,A.D. and Shalev,A.
  TITLE     Increased insulin translation from an insulin splice-variant
            overexpressed in diabetes, obesity, and insulin resistance
  JOURNAL   Mol Endocrinol 19 (3), 794-803 (2005)
   PUBMED   15550470
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Zemel,S., Bartolomei,M.S. and Tilghman,S.M.
  TITLE     Physical linkage of two mammalian imprinted genes, H19 and
            insulin-like growth factor 2
  JOURNAL   Nat Genet 2 (1), 61-65 (1992)
   PUBMED   1303252
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Sawa,T., Ohgaku,S., Morioka,H. and Yano,S.
  TITLE     Molecular cloning and DNA sequence analysis of preproinsulin genes
            in the NON mouse, an animal model of human non-obese,
            non-insulin-dependent diabetes mellitus
  JOURNAL   J Mol Endocrinol 5 (1), 61-67 (1990)
   PUBMED   2397023
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Wentworth,B.M., Schaefer,I.M., Villa-Komaroff,L. and Chirgwin,J.M.
  TITLE     Characterization of the two nonallelic genes encoding mouse
            preproinsulin
  JOURNAL   J Mol Evol 23 (4), 305-312 (1986)
   PUBMED   3104603
REFERENCE   10 (residues 1 to 110)
  AUTHORS   Bunzli,H.F., Glatthaar,B., Kunz,P., Mulhaupt,E. and Humbel,R.E.
  TITLE     Amino acid sequence of the two insulins from mouse (Maus musculus)
  JOURNAL   Hoppe Seylers Z Physiol Chem 353 (3), 451-458 (1972)
   PUBMED   5063718
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP775562.1, AK007612.1 and
            BC099934.1.
            
            Summary: This gene encodes insulin, a peptide hormone that plays a
            vital role in the regulation of carbohydrate and lipid metabolism.
            The encoded precursor protein undergoes proteolytic cleavage to
            produce a disulfide-linked heterodimeric functional protein that is
            stored in secretory granules. An increase in blood glucose levels,
            among others, induces the release of insulin from the secretory
            granules. Mice deficient in the functional hormone encoded by this
            gene develop diabetes mellitus. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP775562.1, AK007612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.0 cM"
     Protein         1..110
                     /product="insulin-2 preproprotein"
                     /note="insulin-2; proinsulin"
                     /calculated_mol_wt=9497
     sig_peptide     1..24
                     /note="/evidence=ECO:0000269|PubMed:5063718; propagated
                     from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=2886
     proprotein      25..110
                     /product="insulin-2 proprotein"
                     /experiment="experimental evidence [PMID:5063718]"
                     /calculated_mol_wt=9497
     mat_peptide     25..54
                     /product="Insulin-2 B chain.
                     /evidence=ECO:0000269|PubMed:3104603. /id=PRO_0000015845"
                     /note="propagated from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=3433
     Region          26..110
                     /region_name="IlGF_insulin_like"
                     /note="IlGF_like family, insulin_like subgroup, specific
                     to vertebrates. Members include a number of peptides
                     including insulin and insulin-like growth factors I and
                     II, which play a variety of roles in controlling processes
                     such as metabolism, growth and...; cd04367"
                     /db_xref="CDD:239833"
     Site            order(32,35,37,108)
                     /site_type="active"
                     /note="putative receptor binding surface [active]"
                     /db_xref="CDD:239833"
     mat_peptide     90..110
                     /product="Insulin-2 A chain.
                     /evidence=ECO:0000269|PubMed:3104603. /id=PRO_0000015847"
                     /note="propagated from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=2370
     CDS             1..110
                     /gene="Ins2"
                     /gene_synonym="Ins-2; InsII; Mody; Mody4"
                     /coded_by="NM_008387.5:92..424"
                     /db_xref="CCDS:CCDS22034.1"
                     /db_xref="GeneID:16334"
                     /db_xref="MGI:MGI:96573"
ORIGIN      
        1 malwmrflpl lallflwesh ptqafvkqhl cgshlvealy lvcgergffy tpmsrreved
       61 pqvaqlelgg gpgagdlqtl alevaqqkrg ivdqcctsic slyqlenycn
//
LOCUS       NP_001396759             695 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 8 [Mus musculus].
ACCESSION   NP_001396759 XP_006505588
VERSION     NP_001396759.1
DBSOURCE    REFSEQ: accession NM_001409830.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 695)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 695)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 695)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 695)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 695)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 695)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 695)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 695)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 695)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 695)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 22, 2022 this sequence version replaced XP_006505588.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422586.347017.1,
                                           SRR13422592.383766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..695
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     8"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=79419
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          149..240
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          508..539
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          558..677
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(562,564..567,569,573,576,578,628..629,632,652,668)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(570..573,590,597,600..601,604,608,611..617,634..638,
                     646,673,675..676)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(572..573,606..607,610,612,614,627,634..638,675)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(572..573,606..607,610,612,614,627,634..637)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(590,597,600..601,604,608,613,615..617,646,673,
                     675..677)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..695
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409830.1:145..2232"
                     /note="isoform 8 is encoded by transcript variant 23"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtscsvtsdl dfpaqviplk tlnavasvpi myswsplqqn fmvedetvlh
      121 nipymgdevl dqdgtfieel iknydgkvhg drecgfinde ifvelvnalg qynddddddd
      181 gddpdereek qkdlednrdd ketcpprkfp adkifeaiss mfpdkgtaee lkekykelte
      241 qqlpgalppe ctpnidgpna ksvqreqslh sfhtlfcrrc fkydcflhpf hatpntykrk
      301 ntetaldnkp cgpqcyqhle gakefaaalt aeriktppkr pggrrrgrlp nnssrpstpt
      361 isvleskdtd sdreagtetg genndkeeee kkdetsssse ansrcqtpik mkpnieppen
      421 vewsgaeasm frvligtyyd nfcaiarlig tktcrqvyef rvkessiiap vptedvdtpp
      481 rkkkrkhrlw aahcrkiqlk kgqnrfpgcr ckaqcntkqc pcylavrecd pdlcltcgaa
      541 dhwdsknvsc kncsiqrgsk khlllapsdv agwgifikdp vqknefisey cgeiisqdea
      601 drrgkvydky mcsflfnlnn dfvvdatrkg nkirfanhsv npncyakvmm vngdhrigif
      661 akraiqtgee lffdyrysqa dalkyvgier emeip
//
LOCUS       NP_001034239             580 aa            linear   ROD 27-AUG-2025
DEFINITION  CD44 antigen isoform b precursor [Mus musculus].
ACCESSION   NP_001034239
VERSION     NP_001034239.1
DBSOURCE    REFSEQ: accession NM_001039150.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Deobald,K.N., Steele,S.P., Dominguez,S.R., Whiles,S. and Kawula,T.
  TITLE     Merocytophagy is an integrin-stabilized macrophage response to
            microbes reliant on Syk signaling
  JOURNAL   Front Immunol 16, 1565250 (2025)
   PUBMED   40313956
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Zhang,C., Huang,Q., Ford,N.C., Limjunyawong,N., Lin,Q., Yang,F.,
            Cui,X., Uniyal,A., Liu,J., Mahabole,M., He,H., Wang,X., Duff,I.,
            Wang,Y., Wan,J., Zhu,G., Raja,S.N., Jia,H., Yang,D., Dong,X.,
            Cao,X., Tseng,S.C., He,S. and Guan,Y.
  TITLE     Human birth tissue products as a non-opioid medicine to inhibit
            post-surgical pain
  JOURNAL   Elife 13, 101269 (2024)
   PUBMED   39671234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 580)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (residues 1 to 580)
  AUTHORS   Araujo David,B., Atif,J., Vargas E Silva Castanheira,F., Yasmin,T.,
            Guillot,A., Ait Ahmed,Y., Peiseler,M., Hommes,J.W., Salm,L.,
            Brundler,M.A., Surewaard,B.G.J., Elhenawy,W., MacParland,S.,
            Ginhoux,F., McCoy,K. and Kubes,P.
  TITLE     Kupffer cell reverse migration into the liver sinusoids mitigates
            neonatal sepsis and meningitis
  JOURNAL   Sci Immunol 9 (101), eadq9704 (2024)
   PUBMED   39485859
REFERENCE   6  (residues 1 to 580)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   7  (residues 1 to 580)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 580)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   9  (residues 1 to 580)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   10 (residues 1 to 580)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844155.6 and CT010324.1.
            
            Transcript Variant: This variant (2) lacks several alternate,
            in-frame, exons, compared to variant 1. The resulting protein
            (isoform b) is shorter when it is compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051388.1, CT010324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     Protein         1..580
                     /product="CD44 antigen isoform b precursor"
                     /note="PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; lymphocyte antigen 24; phagocytic
                     glycoprotein 1; extracellular matrix receptor III; GP90
                     lymphocyte homing/adhesion receptor; phagocytic
                     glycoprotein I"
                     /calculated_mol_wt=60863
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2420
     Region          30..173
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(42,45..46,72,82..83,104..105,109)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     CDS             1..580
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /coded_by="NM_001039150.1:320..2062"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS16470.1"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
ORIGIN      
        1 mdkfwwhtaw glcllqlsla hphqqidlnv tcryagvfhv ekngrysisr teaadlcqaf
       61 nstlptmdqm klalskgfet crygfiegnv viprihpnai caanhtgvyi lvtsntshyd
      121 tycfnasapp eedctsvtdl pnsfdgpvti tivnrdgtry skkgeyrthq edidasniid
      181 ddvssgstie kstpesyilh tylpteqptg dqddsffirs tlattpnsta eaaatqqetw
      241 fqngwqgknp ptpsedshvt egttasahnn hpsqrittqs qedvswtdff dpishpmgqg
      301 hqteskdtds shsttlqpta apnthlvedl nrtgplsvtt pqshsqnfst lhgepeeden
      361 hpttsilpss tksgakdarr ggslptdttt svegytfqyp dtmengtlfp vtpaktevfg
      421 etevtlatds nvnvdgslpg drdsskdsrg ssrtvthgse laghssanqd sgvtttsgpm
      481 rrpqipewli ilasllalal ilavciavns rrrcgqkkkl vinggngtve drkpselnge
      541 asksqemvhl vnkepsetpd qcmtadetrn lqsvdmkigv
//
LOCUS       NP_835186                368 aa            linear   ROD 27-AUG-2025
DEFINITION  ELKS/Rab6-interacting/CAST family member 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_835186 XP_358367
VERSION     NP_835186.1
DBSOURCE    REFSEQ: accession NM_178085.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 368)
  AUTHORS   Yue,L., Kajino,K., Kobayashi,T., Sugitani,Y., Sugihara,M.,
            Kakuta,S., Harada,N., Sasano,H., Kojima,M., Abe,M., Lu,R.,
            Otsuji,N., Orimo,A. and Hino,O.
  TITLE     ERC/Mesothelin Is Associated with the Formation of Microvilli on
            the Mesothelium and Has Limited Functional Relevance Under
            Physiological Conditions
  JOURNAL   Int J Mol Sci 26 (9), 4330 (2025)
   PUBMED   40362566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 368)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   3  (residues 1 to 368)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 368)
  AUTHORS   Hagiwara,A., Mizutani,A., Kawamura,S., Abe,M., Hida,Y., Sakimura,K.
            and Ohtsuka,T.
  TITLE     Critical Role of the Presynaptic Protein CAST in Maintaining the
            Photoreceptor Ribbon Synapse Triad
  JOURNAL   Int J Mol Sci 24 (8), 7251 (2023)
   PUBMED   37108413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 368)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 368)
  AUTHORS   Schoch,S., Mittelstaedt,T., Kaeser,P.S., Padgett,D., Feldmann,N.,
            Chevaleyre,V., Castillo,P.E., Hammer,R.E., Han,W., Schmitz,F.,
            Lin,W. and Sudhof,T.C.
  TITLE     Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered
            neurotransmitter release
  JOURNAL   EMBO J 25 (24), 5852-5863 (2006)
   PUBMED   17124501
REFERENCE   7  (residues 1 to 368)
  AUTHORS   Deguchi-Tawarada,M., Inoue,E., Takao-Rikitsu,E., Inoue,M.,
            Ohtsuka,T. and Takai,Y.
  TITLE     CAST2: identification and characterization of a protein
            structurally related to the presynaptic cytomatrix protein CAST
  JOURNAL   Genes Cells 9 (1), 15-23 (2004)
   PUBMED   14723704
REFERENCE   8  (residues 1 to 368)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (residues 1 to 368)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 368)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125102.4 and AK048990.1.
            
            On Dec 17, 2003 this sequence version replaced XP_358367.1.
            
            Transcript Variant: This variant (2) lacks several exons and its 3'
            terminal exon extends past a splice site that is used in variant 1.
            This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. It encodes isoform 2 which is shorter and has a distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048990.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     Protein         1..368
                     /product="ELKS/Rab6-interacting/CAST family member 1
                     isoform 2"
                     /note="Rab6 interacting protein 2; RAB6-interacting
                     protein 2; CAZ-associated structural protein 2"
                     /calculated_mol_wt=43295
     Region          3..>347
                     /region_name="Cast"
                     /note="RIM-binding protein of the cytomatrix active zone;
                     pfam10174"
                     /db_xref="CDD:431111"
     CDS             1..368
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /coded_by="NM_178085.3:293..1399"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS20476.1"
                     /db_xref="GeneID:111173"
                     /db_xref="MGI:MGI:2151013"
ORIGIN      
        1 mdlqtqlkev lrendllrkd vevkesklss smnsiktfws pelkkeralr kdeaskitiw
       61 keqyrvvqee nqhmqmtiqa lqdelriqrd lnqlfqqdss srtgepcvae lteenfqrlh
      121 aeherqakel fllrktleem elrietqkqt lnardesikk llemlqskgl sakateedhe
      181 rtrrlaeaem hvhhleslle qkekennmlr eemhrrfena pdsaktkalq tviemkdski
      241 ssmerglrdl eeeiqmlksn galsseeree emkqmevyrs hskfmknkig qvkqelsrkd
      301 tellalqtkl etltnqfsds kqhievlkes ltakeqraai lqtevksfcd lcriqsipsf
      361 illyicyv
//
LOCUS       NP_001123652             291 aa            linear   ROD 27-AUG-2025
DEFINITION  troponin T, cardiac muscle isoform e [Mus musculus].
ACCESSION   NP_001123652
VERSION     NP_001123652.1
DBSOURCE    REFSEQ: accession NM_001130180.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 291)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 291)
  AUTHORS   Lin,S., Dieterich,C., Britto-Borges,T., Gunther,S., Kreher,S.,
            Eibach,Y., Kuenne,C., Schneider,A. and Braun,T.
  TITLE     Rbpms2 prevents major cardiac defects in cardiomyocyte-specific
            Rbpms-deficient mice
  JOURNAL   Dev Cell (2025) In press
   PUBMED   40602408
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 291)
  AUTHORS   Abukar,S., Embacher,P.A., Ciccarelli,A., Varsani-Brown,S.,
            North,I.G.W., Dean,J.A., Briscoe,J. and Ivanovitch,K.
  TITLE     Early coordination of cell migration and cardiac fate determination
            during mammalian gastrulation
  JOURNAL   EMBO J 44 (12), 3327-3359 (2025)
   PUBMED   40360834
REFERENCE   4  (residues 1 to 291)
  AUTHORS   Abraham,E., Kostina,A., Volmert,B., Roule,T., Huang,L., Yu,J.,
            Williams,A.E., Megill,E., Douglas,A., Pericak,O.M., Morris,A.,
            Stronati,E., Larrinaga-Zamanillo,A., Fueyo,R., Zubillaga,M.,
            Andrake,M.D., Akizu,N., Aguirre,A. and Estaras,C.
  TITLE     A retinoic acid:YAP1 signaling axis controls atrial lineage
            commitment
  JOURNAL   Cell Rep 44 (5), 115687 (2025)
   PUBMED   40343798
REFERENCE   5  (residues 1 to 291)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 291)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   7  (residues 1 to 291)
  AUTHORS   Tardiff,J.C., Factor,S.M., Tompkins,B.D., Hewett,T.E., Palmer,B.M.,
            Moore,R.L., Schwartz,S., Robbins,J. and Leinwand,L.A.
  TITLE     A truncated cardiac troponin T molecule in transgenic mice suggests
            multiple cellular mechanisms for familial hypertrophic
            cardiomyopathy
  JOURNAL   J Clin Invest 101 (12), 2800-2811 (1998)
   PUBMED   9637714
REFERENCE   8  (residues 1 to 291)
  AUTHORS   Jin,J.P., Wang,J. and Zhang,J.
  TITLE     Expression of cDNAs encoding mouse cardiac troponin T isoforms:
            characterization of a large sample of independent clones
  JOURNAL   Gene 168 (2), 217-221 (1996)
   PUBMED   8654947
REFERENCE   9  (residues 1 to 291)
  AUTHORS   Jin,J.P., Zhang,J. and Wang,J.
  TITLE     An embryonic alternative transcription initiation site and the
            5'-upstream structure of mouse cardiac troponin T gene
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1168-1174 (1995)
   PUBMED   7575526
REFERENCE   10 (residues 1 to 291)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162441.11 and L47552.1.
            
            Transcript Variant: This variant (7) lacks two alternate in-frame
            exons in the 5' coding region, and includes an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The resulting
            isoform (e) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L47552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.32 cM"
     Protein         1..291
                     /product="troponin T, cardiac muscle isoform e"
                     /note="troponin T, cardiac muscle; tnTc; cardiac muscle
                     troponin T; cardiac TnT"
                     /calculated_mol_wt=34416
     Region          96..234
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..291
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /coded_by="NM_001130180.2:128..1003"
                     /note="isoform e is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS48378.1"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
ORIGIN      
        1 msdaeevvee yeeeqeeqee aveeeeagga epepegeaet eeanveevgp deeakdaeeg
       61 pvedtkpkps rlfmpnlvpp kipdgervdf ddihrkrvek dlnelqtlie ahfenrkkee
      121 eelislkdri ekrraeraeq qrirnereke rqnrlaeera rreeeenrrk aedearkkka
      181 lsnmmhfggy iqkqaqterk sgkrqterek kkkilaerrk alaidhlned qlrekakelw
      241 qsihnleaek fdlqekfkqq kyeinvlrnr indnqkvskt rgkakvtgrw k
//
LOCUS       NP_444434               1120 aa            linear   ROD 27-AUG-2025
DEFINITION  ELKS/Rab6-interacting/CAST family member 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_444434 NP_077786 XP_001003358 XP_922796 XP_930229 XP_930234
            XP_930237 XP_930239 XP_930241 XP_930243 XP_930244 XP_930248
            XP_930253 XP_930255
VERSION     NP_444434.2
DBSOURCE    REFSEQ: accession NM_053204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1120)
  AUTHORS   Yue,L., Kajino,K., Kobayashi,T., Sugitani,Y., Sugihara,M.,
            Kakuta,S., Harada,N., Sasano,H., Kojima,M., Abe,M., Lu,R.,
            Otsuji,N., Orimo,A. and Hino,O.
  TITLE     ERC/Mesothelin Is Associated with the Formation of Microvilli on
            the Mesothelium and Has Limited Functional Relevance Under
            Physiological Conditions
  JOURNAL   Int J Mol Sci 26 (9), 4330 (2025)
   PUBMED   40362566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1120)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   3  (residues 1 to 1120)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1120)
  AUTHORS   Hagiwara,A., Mizutani,A., Kawamura,S., Abe,M., Hida,Y., Sakimura,K.
            and Ohtsuka,T.
  TITLE     Critical Role of the Presynaptic Protein CAST in Maintaining the
            Photoreceptor Ribbon Synapse Triad
  JOURNAL   Int J Mol Sci 24 (8), 7251 (2023)
   PUBMED   37108413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1120)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1120)
  AUTHORS   Schoch,S., Mittelstaedt,T., Kaeser,P.S., Padgett,D., Feldmann,N.,
            Chevaleyre,V., Castillo,P.E., Hammer,R.E., Han,W., Schmitz,F.,
            Lin,W. and Sudhof,T.C.
  TITLE     Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered
            neurotransmitter release
  JOURNAL   EMBO J 25 (24), 5852-5863 (2006)
   PUBMED   17124501
REFERENCE   7  (residues 1 to 1120)
  AUTHORS   Deguchi-Tawarada,M., Inoue,E., Takao-Rikitsu,E., Inoue,M.,
            Ohtsuka,T. and Takai,Y.
  TITLE     CAST2: identification and characterization of a protein
            structurally related to the presynaptic cytomatrix protein CAST
  JOURNAL   Genes Cells 9 (1), 15-23 (2004)
   PUBMED   14723704
REFERENCE   8  (residues 1 to 1120)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (residues 1 to 1120)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 1120)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125102.4, AC161060.6 and AC128662.4.
            
            On Dec 28, 2006 this sequence version replaced NP_444434.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF340029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     Protein         1..1120
                     /product="ELKS/Rab6-interacting/CAST family member 1
                     isoform 1"
                     /note="Rab6 interacting protein 2; RAB6-interacting
                     protein 2; CAZ-associated structural protein 2"
                     /calculated_mol_wt=128200
     Region          1..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            10
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUD2; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUD2; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUD2; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            55
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            94
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUD2; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Region          154..986
                     /region_name="Cast"
                     /note="RIM-binding protein of the cytomatrix active zone;
                     pfam10174"
                     /db_xref="CDD:431111"
     Region          801..840
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            824
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            965
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            1009
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q811U3; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Site            1050
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUD2; propagated from
                     UniProtKB/Swiss-Prot (Q99MI1.1)"
     Region          1072..1112
                     /region_name="RBD-FIP"
                     /note="FIP domain; pfam09457"
                     /db_xref="CDD:462805"
     CDS             1..1120
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /coded_by="NM_053204.2:569..3931"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39611.1"
                     /db_xref="GeneID:111173"
                     /db_xref="MGI:MGI:2151013"
ORIGIN      
        1 mygsarsvgk vepssqspgr sprlprsprl ghrrtnstgg ssgnsvgggs gktlsmeniq
       61 slnaayatsg pmylsdhenv gaetpkstmt lgrsggrlpy gvrmtamgss pniassgvas
      121 dtiafgehhl ppvsmastvp hslrqardnt imdlqtqlke vlrendllrk dvevkeskls
      181 ssmnsiktfw spelkkeral rkdeaskiti wkeqyrvvqe enqhmqmtiq alqdelriqr
      241 dlnqlfqqds ssrtgepcva elteenfqrl haeherqake lfllrktlee melrietqkq
      301 tlnardesik kllemlqskg lsakateedh ertrrlaeae mhvhhlesll eqkekennml
      361 reemhrrfen apdsaktkal qtviemkdsk issmerglrd leeeiqmlks ngalsseere
      421 eemkqmevyr shskfmknkv eqlkeelssk daqgeelkkr aaglqseigq vkqelsrkdt
      481 ellalqtkle tltnqfsdsk qhievlkesl takeqraail qtevdalrlr leeketmlnk
      541 ktkqiqdmae ekgtqageih dlkdmldvke rkvnvlqkki enlqeqlrdk ekqmsslker
      601 vkslqadttn tdtalttlee aladkertie rlkeqrdrde rekqeeidty kkdlkdlrek
      661 vsllqgdlse keaslldike hasslassgl kkdsrlktle ialeqkkeec lkmesqlkka
      721 heatlearas pemsdriqql ereisrykde sskaqtevdr lleilkeven ekndkdkkia
      781 elesltsrqv kdqnkkvanl khkeqvekkk saqmleearr redslsdssq qlqdslrkkd
      841 drieeleeal resvqitaer emvlaqeesa rtnaekqvee llmamekvkq elesmkakls
      901 stqqslaeke thltnlraer rkhleevlem kqeallaais ekdanialle lssskkktqe
      961 evaalkrekd rlvqqlkqqt qnrmklmadn yeddhfrssr snqtnhkpsp dqiiqpllel
     1021 dqnrsklkly ighltalchd rdplilrglt ppasynadge qaawenelqk mtqeqlqnel
     1081 ekvegdnael qefantilqq iadhcpdile qvvnaleess
//
LOCUS       NP_001300849             810 aa            linear   ROD 27-AUG-2025
DEFINITION  hypoxia-inducible factor 1-alpha isoform 3 [Mus musculus].
ACCESSION   NP_001300849 XP_011242299
VERSION     NP_001300849.1
DBSOURCE    REFSEQ: accession NM_001313920.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 810)
  AUTHORS   Sanchez-Garcia,M.A., Lara-Urena,N., March-Diaz,R., Ortega-de San
            Luis,C., Quinones-Canete,S., Mora-Romero,B., Barba-Reyes,J.M.,
            Cabello-Rivera,D., Romero-Molina,C., Heras-Garvin,A., Navarro,V.,
            Lopez-Barneo,J., Vizuete,M., Vitorica,J., Munoz-Cabello,A.M.,
            Munoz-Manchado,A.B., Cokman,M.E., Rosales-Nieves,A.E. and
            Pascual,A.
  TITLE     Inactivation of the PHD3-FOXO3 axis blunts the type I interferon
            response in microglia and ameliorates Alzheimer's disease
            progression
  JOURNAL   Sci Adv 11 (22), eadu2244 (2025)
   PUBMED   40435260
REFERENCE   2  (residues 1 to 810)
  AUTHORS   Pekayvaz,K., Kilani,B., Joppich,M., Eivers,L., Brambs,S.,
            Knottenberg,V., Akgol,S., Yue,K., Li,L., Martinez-Navarro,A.,
            Kaiser,R., Meissner,N., Schulz,H., Belz,L., Akhalkatsi,A.,
            Stockhausen,S., Mueller,T.T., Millonig,S., Hartelt,L., Gold,C.,
            Janjic,A., Polewka,V., Wendler,F., Droste Zu Senden,A., Titova,A.,
            Leunig,A., Voelkl,M., Engelmann,B., Hernandez Petzsche,M.R.,
            Boeckh-Behrens,T., Liebig,T., Winning,S., Fandrey,J., Dichgans,M.,
            Enard,W., Zimmer,R., Tiedt,S., Massberg,S., Nicolai,L. and Stark,K.
  TITLE     Immunothrombolytic monocyte-neutrophil axes dominate the
            single-cell landscape of human thrombosis and correlate with
            thrombus resolution
  JOURNAL   Immunity 58 (5), 1343-1358 (2025)
   PUBMED   40280129
REFERENCE   3  (residues 1 to 810)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 810)
  AUTHORS   Ruan,W., Li,T., Bang,I.H., Lee,J., Deng,W., Ma,X., Luo,C., Du,F.,
            Yoo,S.H., Kim,B., Li,J., Yuan,X., Figarella,K., An,Y.A., Wang,Y.Y.,
            Liang,Y., DeBerge,M., Zhang,D., Zhou,Z., Wang,Y., Gorham,J.M.,
            Seidman,J.G., Seidman,C.E., Aranki,S.F., Nair,R., Li,L., Narula,J.,
            Zhao,Z., Gorfe,A.A., Muehlschlegel,J.D., Tsai,K.L. and
            Eltzschig,H.K.
  TITLE     BMAL1-HIF2A heterodimer modulates circadian variations of
            myocardial injury
  JOURNAL   Nature 641 (8064), 1017-1028 (2025)
   PUBMED   40269168
REFERENCE   5  (residues 1 to 810)
  AUTHORS   Guo,C., Niu,Y., Pan,X., Sharma,D., Lau,E., Jin,Y., Luxardi,G.,
            Amanullah,M., Lo,K., Moshiri,A., Qian,J., Montaner,S. and Sodhi,A.
  TITLE     Hypoglycemia promotes inner blood-retinal barrier breakdown and
            retinal vascular leakage in diabetic mice
  JOURNAL   Sci Transl Med 17 (796), eadq5355 (2025)
   PUBMED   40305573
REFERENCE   6  (residues 1 to 810)
  AUTHORS   Li,H., Ko,H.P. and Whitlock,J.P.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 810)
  AUTHORS   Wood,S.M., Gleadle,J.M., Pugh,C.W., Hankinson,O. and Ratcliffe,P.J.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 810)
  AUTHORS   Semenza,G.L., Rue,E.A., Iyer,N.V., Pang,M.G. and Kearns,W.G.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 810)
  AUTHORS   Wenger,R.H., Rolfs,A., Marti,H.H., Guenet,J.L. and Gassmann,M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 810)
  AUTHORS   Obara,N. and Takeda,M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Sep 11, 2015 this sequence version replaced XP_011242299.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) has an alternate 5' structure,
            which results in the use of a downstream start codon, and uses an
            alternate in-frame splice site in the 3' coding region compared to
            variant 1. The encoded isoform (3) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95580.1, SRR17253013.247521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..810
                     /product="hypoxia-inducible factor 1-alpha isoform 3"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=90484
     Region          1..71
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(6..7,9..11,14..15,17..18,43..44)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Site            order(20..21,23..24,27..28,31..32,43..45,48..49,52,55..56,
                     59)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          81..136
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          242..327
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(243,247,253,266..269,295,300)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(263,267,275,278..279,307,309)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          538..567
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:463274"
     Region          773..809
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     CDS             1..810
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001313920.2:89..2521"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS83968.1"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 msserrkeks rdaarsrrsk esevfyelah qlplphnvss hldkasvmrl tisylrvrkl
       61 ldaggldsed emkaqmdcfy lkaldgfvmv ltddgdmvyi sdnvnkymgl tqfeltghsv
      121 fdfthpcdhe emremlthrn gpvrkgkeln tqrsfflrmk ctltsrgrtm niksatwkvl
      181 hctghihvyd tnsnqpqcgy kkppmtclvl icepiphpsn ieipldsktf lsrhsldmkf
      241 sycderitel mgyepeellg rsiyeyyhal dsdhltkthh dmftkgqvtt gqyrmlakrg
      301 gyvwvetqat viyntknsqp qcivcvnyvv sgiiqhdlif slqqtesvlk pvessdmkmt
      361 qlftkvesed tsclfdklkk epdaltllap aagdtiisld fgsddteted qqledvplyn
      421 dvmfpssnek lninlamspl pssetpkplr ssadpalnqe valklesspe slglsftmpq
      481 iqdqpaspsd gstrqsspep nspseycfdv dsdmvnvfkl elveklfaed teaknpfstq
      541 dtdldlemla pyipmdddfq lrsfdqlspl esnspsppsm stvtgfqqtq lqkptitata
      601 tttattdesk tetkdnkedi kiliaspsst qvpqetttak asaysgthsr taspdragkr
      661 vieqtdkahp rslnlsatln qrntvpeeel npktiasqna qrkrkmehdg slfqaagigt
      721 llqqpgdcap tmslswkrvk gfisseqngt eqktiilips dlacrllgqs mdesglpqlt
      781 sydcevnapi qgsrnllqge ellraldqvn
//
LOCUS       NP_084336                118 aa            linear   ROD 27-AUG-2025
DEFINITION  basic leucine zipper transcriptional factor ATF-like 3 [Mus
            musculus].
ACCESSION   NP_084336 XP_355268
VERSION     NP_084336.1
DBSOURCE    REFSEQ: accession NM_030060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 118)
  AUTHORS   Yin,X., Ding,Z., Yu,L., Zhang,X., Gao,Y., Li,Y., Liu,Z. and Fu,Y.X.
  TITLE     Orchestrating intratumoral DC-T cell immunity for enhanced tumor
            control via radiotherapy-activated TLR7/8 prodrugs in mice
  JOURNAL   Nat Commun 16 (1), 6020 (2025)
   PUBMED   40592817
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 118)
  AUTHORS   Ben-Simon,Y., Hooper,M., Narayan,S., Daigle,T.L., Dwivedi,D.,
            Way,S.W., Oster,A., Stafford,D.A., Mich,J.K., Taormina,M.J.,
            Martinez,R.A., Opitz-Araya,X., Roth,J.R., Alexander,J.R., Allen,S.,
            Amster,A., Arbuckle,J., Ayala,A., Baker,P.M., Bakken,T.E.,
            Barcelli,T., Barta,S., Bendrick,J., Bertagnolli,D., Bielstein,C.,
            Bishwakarma,P., Bowlus,J., Boyer,G., Brouner,K., Casian,B.,
            Casper,T., Chakka,A.B., Chakrabarty,R., Chance,R.K., Chavan,S.,
            Clark,M., Colbert,K., Collman,F., Daniel,S., Departee,M.,
            DiValentin,P., Donadio,N., Dotson,N., Egdorf,T., Fliss,T.,
            Gabitto,M., Garcia,J., Gary,A., Gasperini,M., Gloe,J., Goldy,J.,
            Gore,B.B., Graybuck,L., Greisman,N., Haeseleer,F., Halterman,C.,
            Haradon,Z., Hastings,S.D., Helback,O., Ho,W., Hockemeyer,D.,
            Huang,C., Huff,S., Hunker,A., Johansen,N., Jones,D., Juneau,Z.,
            Kalmbach,B., Kannan,M., Khem,S., Kussick,E., Kutsal,R., Larsen,R.,
            Lee,C., Lee,A.Y., Leibly,M., Lenz,G.H., Li,S., Liang,E., Lusk,N.,
            Madigan,Z., Malloy,J., Malone,J., McCue,R., Melchor,J.,
            Mollenkopf,T., Moosman,S., Morin,E., Newman,D., Ng,L., Ngo,K.,
            Omstead,V., Otto,S., Oyama,A., Pena,N., Pham,T., Phillips,E.,
            Pom,C.A., Potekhina,L., Ransford,S., Ray,P.L., Rette,D.,
            Reynoldson,C., Rimorin,C., Rocha,D., Ruiz,A., Sanchez,R.E.A.,
            Sawyer,L., Sedeno-Cortes,A., Sevigny,J.P., Shapovalova,N.,
            Shepard,N., Shulga,L., Sigler,A.R., Siverts,L., Soliman,S.,
            Somasundaram,S., Staats,B., Stewart,K., Szelenyi,E., Tieu,M.,
            Trader,C., Tran,A., van Velthoven,C.T.J., Walker,M., Wang,Y.,
            Weed,N., Wirthlin,M., Wood,T., Wynalda,B., Yao,Z., Zhou,T.,
            Ariza,J., Dee,N., Reding,M., Ronellenfitch,K., Mufti,S.,
            Sunkin,S.M., Smith,K.A., Esposito,L., Waters,J., Thyagarajan,B.,
            Yao,S., Lein,E.S., Zeng,H., Levi,B.P., Ngai,J., Ting,J.T. and
            Tasic,B.
  TITLE     A suite of enhancer AAVs and transgenic mouse lines for genetic
            access to cortical cell types
  JOURNAL   Cell 188 (11), 3045-3064 (2025)
   PUBMED   40403729
REFERENCE   3  (residues 1 to 118)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 118)
  AUTHORS   Chao,C.J., Zhang,E., Trinh,D.N., Udofa,E., Lin,H., Silvers,C.,
            Huo,J., He,S., Zheng,J., Cai,X., Bao,Q., Zhang,L., Phan,P.,
            Elgendy,S.M., Shi,X., Burdette,J.E., Lee,S.S., Gao,Y., Zhang,P. and
            Zhao,Z.
  TITLE     Integrating antigen capturing nanoparticles and type 1 conventional
            dendritic cell therapy for in situ cancer immunization
  JOURNAL   Nat Commun 16 (1), 4578 (2025)
   PUBMED   40379691
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 118)
  AUTHORS   Lai,Y.G., Liao,H.T., Chen,Y.H., Huang,S.W., Liou,Y.H., Wu,Z.Q. and
            Liao,N.S.
  TITLE     cGAS and STING in Host Myeloid Cells Are Essential for Effective
            Cyclophosphamide Treatment of Advanced Breast Cancer
  JOURNAL   Cancers (Basel) 17 (7), 1130 (2025)
   PUBMED   40227734
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 118)
  AUTHORS   Bar-On,L., Birnberg,T., Lewis,K.L., Edelson,B.T., Bruder,D.,
            Hildner,K., Buer,J., Murphy,K.M., Reizis,B. and Jung,S.
  TITLE     CX3CR1+ CD8alpha+ dendritic cells are a steady-state population
            related to plasmacytoid dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (33), 14745-14750 (2010)
   PUBMED   20679228
REFERENCE   7  (residues 1 to 118)
  AUTHORS   Edelson,B.T., KC,W., Juang,R., Kohyama,M., Benoit,L.A.,
            Klekotka,P.A., Moon,C., Albring,J.C., Ise,W., Michael,D.G.,
            Bhattacharya,D., Stappenbeck,T.S., Holtzman,M.J., Sung,S.S.,
            Murphy,T.L., Hildner,K. and Murphy,K.M.
  TITLE     Peripheral CD103+ dendritic cells form a unified subset
            developmentally related to CD8alpha+ conventional dendritic cells
  JOURNAL   J Exp Med 207 (4), 823-836 (2010)
   PUBMED   20351058
REFERENCE   8  (residues 1 to 118)
  AUTHORS   McCartney,S., Vermi,W., Gilfillan,S., Cella,M., Murphy,T.L.,
            Schreiber,R.D., Murphy,K.M. and Colonna,M.
  TITLE     Distinct and complementary functions of MDA5 and TLR3 in
            poly(I:C)-mediated activation of mouse NK cells
  JOURNAL   J Exp Med 206 (13), 2967-2976 (2009)
   PUBMED   19995959
REFERENCE   9  (residues 1 to 118)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (residues 1 to 118)
  AUTHORS   Hildner,K., Edelson,B.T., Purtha,W.E., Diamond,M., Matsushita,H.,
            Kohyama,M., Calderon,B., Schraml,B.U., Unanue,E.R., Diamond,M.S.,
            Schreiber,R.D., Murphy,T.L. and Murphy,K.M.
  TITLE     Batf3 deficiency reveals a critical role for CD8alpha+ dendritic
            cells in cytotoxic T cell immunity
  JOURNAL   Science 322 (5904), 1097-1100 (2008)
   PUBMED   19008445
  REMARK    GeneRIF: study describes a transcription factor, Batf3, that
            controls development of CD8+ dendritic cells; dendritic cells from
            Batf3-/- mice were defective in cross-presentation, and Batf3-/-
            mice lacked virus-specific CD8+ T cell responses to West Nile virus
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK020278.1.
            
            On Aug 30, 2004 this sequence version replaced XP_355268.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020278.1, CB181953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..118
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     Protein         1..118
                     /product="basic leucine zipper transcriptional factor
                     ATF-like 3"
                     /note="Jun dimerization protein p21SNFT; B-ATF-3"
                     /calculated_mol_wt=13526
     Region          1..69
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D275.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NR55; propagated from
                     UniProtKB/Swiss-Prot (Q9D275.1)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NR55; propagated from
                     UniProtKB/Swiss-Prot (Q9D275.1)"
     Region          28..85
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Region          30..55
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D275.1)"
     Region          31..82
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269834"
     Site            order(34..35,37..39,41..46,48..50)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269834"
     Site            order(49,52..53,56..57,59..60,63..64,66..67,70..71,73..74,
                     77..78,80..81)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269834"
     Region          56..84
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D275.1)"
     CDS             1..118
                     /gene="Batf3"
                     /gene_synonym="9130211I03Rik; Snft"
                     /coded_by="NM_030060.2:46..402"
                     /db_xref="CCDS:CCDS15615.1"
                     /db_xref="GeneID:381319"
                     /db_xref="MGI:MGI:1925491"
ORIGIN      
        1 msqgppavsv lqrsvdapgn qpqspkdddr kvrrreknrv aaqrsrkkqt qkadklheeh
       61 esleqensvl rreisklkee lrhlsevlke hekmcplllc pmnfvqlrsd pvasclpr
//
LOCUS       NP_035554               2468 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor corepressor 2 isoform 1 [Mus musculus].
ACCESSION   NP_035554
VERSION     NP_035554.3
DBSOURCE    REFSEQ: accession NM_011424.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2468)
  AUTHORS   Qian,S., Zhang,C., Li,W., Song,S., Lin,G., Cheng,Z., Zhou,W.,
            Yin,H., Wang,Y., Li,H., Shen,Y.H. and Sun,Z.
  TITLE     Enzyme-independent functions of HDAC3 in the adult heart
  JOURNAL   Acta Pharm Sin B 15 (7), 3561-3574 (2025)
   PUBMED   40698142
REFERENCE   2  (residues 1 to 2468)
  AUTHORS   Ritter,M.J., Amano,I., van der Spek,A.H., Gower,A.C.,
            Undeutsch,H.J., Rodrigues,V.A.P., Daniel,H.E. and Hollenberg,A.N.
  TITLE     Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism
            via Intestinal Regulation of Carbohydrate Transport
  JOURNAL   Endocrinology 165 (9) (2024)
   PUBMED   39106294
REFERENCE   3  (residues 1 to 2468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 2468)
  AUTHORS   Abe,Y., Kofman,E.R., Almeida,M., Ouyang,Z., Ponte,F., Mueller,J.R.,
            Cruz-Becerra,G., Sakai,M., Prohaska,T.A., Spann,N.J.,
            Resende-Coelho,A., Seidman,J.S., Stender,J.D., Taylor,H., Fan,W.,
            Link,V.M., Cobo,I., Schlachetzki,J.C.M., Hamakubo,T., Jepsen,K.,
            Sakai,J., Downes,M., Evans,R.M., Yeo,G.W., Kadonaga,J.T.,
            Manolagas,S.C., Rosenfeld,M.G. and Glass,C.K.
  TITLE     RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1beta- and
            RNA-dependent co-activator of osteoclast gene expression
  JOURNAL   Mol Cell 83 (19), 3421-3437 (2023)
   PUBMED   37751740
REFERENCE   5  (residues 1 to 2468)
  AUTHORS   Shimizu,H., Horibata,Y., Amano,I., Ritter,M.J., Domae,M., Ando,H.,
            Sugimoto,H., Cohen,R.N. and Hollenberg,A.N.
  TITLE     Nuclear corepressor SMRT acts as a strong regulator of both
            beta-oxidation and suppressor of fibrosis in the differentiation
            process of mouse skeletal muscle cells
  JOURNAL   PLoS One 17 (12), e0277830 (2022)
   PUBMED   36454860
  REMARK    GeneRIF: Nuclear corepressor SMRT acts as a strong regulator of
            both beta-oxidation and suppressor of fibrosis in the
            differentiation process of mouse skeletal muscle cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2468)
  AUTHORS   Kao,H.Y., Downes,M., Ordentlich,P. and Evans,R.M.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
REFERENCE   7  (residues 1 to 2468)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (residues 1 to 2468)
  AUTHORS   Park,E.J., Schroen,D.J., Yang,M., Li,H., Li,L. and Chen,J.D.
  TITLE     SMRTe, a silencing mediator for retinoid and thyroid hormone
            receptors-extended isoform that is more related to the nuclear
            receptor corepressor
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3519-3524 (1999)
   PUBMED   10097068
REFERENCE   9  (residues 1 to 2468)
  AUTHORS   Ordentlich,P., Downes,M., Xie,W., Genin,A., Spinner,N.B. and
            Evans,R.M.
  TITLE     Unique forms of human and mouse nuclear receptor corepressor SMRT
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2639-2644 (1999)
   PUBMED   10077563
REFERENCE   10 (residues 1 to 2468)
  AUTHORS   Rubin,W.W. and LaMantia,A.S.
  TITLE     Age-dependent retinoic acid regulation of gene expression
            distinguishes the cervical, thoracic, lumbar, and sacral spinal
            cord regions during development
  JOURNAL   Dev Neurosci 21 (2), 113-125 (1999)
   PUBMED   10449983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132118.3 and AC139377.4.
            
            On Dec 10, 2011 this sequence version replaced NP_035554.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.96 cM"
     Protein         1..2468
                     /product="nuclear receptor corepressor 2 isoform 1"
                     /note="nuclear receptor corepressor 2; TRAC; N-CoR2; T3
                     receptor-associating factor; thyroid-,
                     retinoic-acid-receptor-associated corepressor; silencing
                     mediator of retinoic acid and thyroid hormone receptor;
                     silencing mediator of retinoid acid and thyroid hormone
                     receptor"
                     /calculated_mol_wt=269136
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            18
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          47..168
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            67
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          143..229
                     /region_name="GPS2_interact"
                     /note="G-protein pathway suppressor 2-interacting domain;
                     pfam15784"
                     /db_xref="CDD:464868"
     Site            149
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          <161..>411
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          190..220
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          254..312
                     /region_name="Interaction with SIN3A/B.
                     /evidence=ECO:0000250|UniProtKB:Q60974"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          389..480
                     /region_name="Deacetylase activation domain (DAD).
                     /evidence=ECO:0000250|UniProtKB:Q9Y618"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          432..475
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cl21498"
                     /db_xref="CDD:473887"
     Site            order(432,461..462,464..465,467..469,471..473)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          487..618
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          <535..>645
                     /region_name="RSC8"
                     /note="RSC chromatin remodeling complex subunit RSC8
                     [Chromatin structure and dynamics / Transcription];
                     COG5259"
                     /db_xref="CDD:227584"
     Site            549
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            550
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          610..653
                     /region_name="Myb_DNA-binding"
                     /note="Myb-like DNA-binding domain; pfam00249"
                     /db_xref="CDD:459731"
     Region          665..1107
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            747
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            750
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            878
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            938
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            945
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            955
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            958
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1172..1196
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1180
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1208
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1219
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1253..1276
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1344..1377
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1349
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1409..1442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1448
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1478..1577
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1564
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1623
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          <1714..2220
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1733..1825
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1745
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1748
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1818
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1853..1874
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1894..1982
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1916
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1959
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            1979
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          1997..2074
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2000
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2008
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2011
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2012
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2014
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2016
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2031
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          2082..2086
                     /region_name="Required for interaction with RARA in the
                     absence of its ligand.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          2090..2094
                     /region_name="CORNR box of ID1.
                     /evidence=ECO:0000250|UniProtKB:Q60974"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          2128..2222
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2211
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          2292..2296
                     /region_name="CORNR box of ID2.
                     /evidence=ECO:0000250|UniProtKB:Q60974"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Region          2339..2455
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU42.3)"
     Site            2367
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y618; propagated from
                     UniProtKB/Swiss-Prot (Q9WU42.3)"
     CDS             1..2468
                     /gene="Ncor2"
                     /gene_synonym="N-CoR; SMRT; SMRTe"
                     /coded_by="NM_011424.4:296..7702"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39285.2"
                     /db_xref="GeneID:20602"
                     /db_xref="MGI:MGI:1337080"
ORIGIN      
        1 msgstqpvaq twraaepryp phgisypvqi arshtdvgll eyqhhprdyt shlspgsiiq
       61 pqrrrpslls efqpgsersq elhlrpesrt flpelgkpdi efteskrprl ellpdtllrp
      121 spllatgqps gsedltkdrs lagklepvsp pspphadpel elapsrlske eliqnmdrvd
      181 reitmveqqi sklkkkqqql eeeaakppep ekpvspppie skhrslvqii ydenrkkaea
      241 ahrileglgp qvelplynqp sdtrqyheni kinqamrkkl ilyfkrrnha rkqweqrfcq
      301 rydqlmeawe kkveriennp rrrakeskvr eyyekqfpei rkqrelqerm qsrvgqrgsg
      361 lsmsaarseh evseiidgls eqenlekqmr qlavippmly dadqqrikfi nmnglmddpm
      421 kvykdrqvtn mwseqerdtf rekfmqhpkn fgliasfler ktvaecvlyy yltkknenyk
      481 slvrrsyrrr gksqqqqqqq qqqqqqqmar ssqeekeeke kekeadkeee kqdaenekee
      541 lskektddts gedndekeav askgrktans qgrrkgritr smaneanhee tatpqqssel
      601 asmemnessr wteeemetak kgllehgrnw saiarmvgsk tvsqcknfyf nykkrqnlde
      661 ilqqhklkme kernarrkkk ktpaaaseet afppaaedee measgasane eelaeeaeas
      721 qasgnevprv gecsgpaavn nssdtesvps prseatkdtg pkptgtealp aatqppvppp
      781 eepavapaep spvpdasgpp spepspspaa ppatvdkdeq eapaapapqt edakeqksea
      841 eeidvgkpee peaseeppes vksdhkeete eepedkakgt eaietvseap lkveeagska
      901 avtkgsssga tqdsdssatc sadevdepeg gdkgrllspr pslltpagdp rastspqkpl
      961 dlkqlkqraa aippivtkvh eppredtvpp kpvppvpppt qhlqpegdvs qqsggsprgk
     1021 srspvppaek eaekpaffpa fptegpklpt epprwssglp fpipprevik tsphaadpsa
     1081 fsytppghpl plglhdsarp vlprppisnp pplissakhp gvlerqlgai sqgmsvqlrv
     1141 phsehakapm gpltmglpla vdpkklgtal gsatsgsitk glpstraadg psyrgsithg
     1201 tpadvlykgt isrivgedsp srldraredt lpkghviyeg kkghvlsyeg gmsvsqcske
     1261 dgrsssgpph etaapkrtyd mmegrvgrtv tsasieglmg raipeqhsph lkeqhhirgs
     1321 itqgiprsyv eaqedylrre akllkregtp pppppprdlt etykprpldp lgplklkpth
     1381 egvvatvkea grsiheipre elrrtpelpl aprplkegsi tqgtplkyds gapstgtkkh
     1441 dvrsiigspg rpfpalhpld imadaraler acyeeslksr sgtssgaggs itrgapvvvp
     1501 elgkprqspl tyedhgapft shlprgspvt treptprlqe gsllsskasq drkltstpre
     1561 iaksphstvp ehhphpispy ehllrgvtgv dlyrghipla fdptsiprgi pleaaaaayy
     1621 lprhlapspt yphlyppyli rgypdtaale nrqtiindyi tsqqmhhnaa samaqradml
     1681 rglspressl alnyaagprg iidlsqvphl pvlvpptpgt pataidrlay lptapppfss
     1741 rhsssplspg gpthlakpta tsssererer ererdksilt stttvehapi wrpgteqssg
     1801 aggssrpash thqhspispr tqdalqqrps vlhntsmkgv vtsvepgtpt vlrststssp
     1861 vrpaatfppa thcplggtle gvyptlmepv llpketsrva rperprvdag hafltkppar
     1921 epasspskss eprslappss shtaiartpa knlaphhasp dppaptsasd lhrektqskp
     1981 fsiqelelrs lgyhsgagys pdgvepispv sspslthdkg lskpleelek shlegelrhk
     2041 qpgpmklsae aahlphlrpl pesqpssspl lqtapgikgh qrvvtlaqhi sevitqdytr
     2101 hhpqqlsgpl paplysfpga scpvldlrrp psdlylpppd hgtpargsph seggkrspep
     2161 sktsvlgsse daiepvsppe gmtepghars taypllyrdg eqgeprmgsk spgntsqppa
     2221 ffskltesns amvkskkqei nkklnthnrn epeynigqpg teifnmpait gaglmtcrsq
     2281 avqehastnm gleaiirkal mgkydqweep pplganafnp lnasaslpaa ampittadgr
     2341 sdhaltspgg ggkakvsgrp ssrkakspap glasgdrpps vssvhsegdc nrrtpltnrv
     2401 wedrpssags tpfpynplim rlqagvmasp pppglaagsg plagphhawd eepkpllcsq
     2461 yetlsdse
//
LOCUS       NP_001348138             792 aa            linear   ROD 27-AUG-2025
DEFINITION  glucocorticoid receptor [Mus musculus].
ACCESSION   NP_001348138 XP_017173324
VERSION     NP_001348138.1
DBSOURCE    REFSEQ: accession NM_001361209.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 792)
  AUTHORS   Zhu,W., Vanderhaeghen,T., Timmermans,S., Vandewalle,J.,
            Eggermont,M., Verhoog,N.J.D. and Libert,C.
  TITLE     Modulation of glucocorticoid receptor function under iron overload
  JOURNAL   Front Immunol 16, 1605420 (2025)
   PUBMED   40607412
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 792)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   3  (residues 1 to 792)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   4  (residues 1 to 792)
  AUTHORS   Cavalcanti de Albuquerque,J.P., Hunter,J., Domingues,R.G.,
            Harno,E., Worth,A.A., Liguori,F.M., D'Alessio,A., Aviello,G.,
            Bechtold,D., White,A., Luckman,S.M., Hepworth,M.R. and
            D'Agostino,G.
  TITLE     Brain sensing of metabolic state regulates circulating monocytes
  JOURNAL   Sci Immunol 10 (106), eadr3226 (2025)
   PUBMED   40184437
REFERENCE   5  (residues 1 to 792)
  AUTHORS   Diba,F., Watson,C.S. and Gametchu,B.
  TITLE     5'UTR sequences of the glucocorticoid receptor 1A transcript encode
            a peptide associated with translational regulation of the
            glucocorticoid receptor
  JOURNAL   J Cell Biochem 81 (1), 149-161 (2001)
   PUBMED   11180405
REFERENCE   6  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Association of the glucocorticoid receptor alternatively-spliced
            transcript 1A with the presence of the high molecular weight
            membrane glucocorticoid receptor in mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 430-446 (1999)
   PUBMED   10412044
REFERENCE   7  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Multiple glucocorticoid receptor transcripts in membrane
            glucocorticoid receptor-enriched S-49 mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 418-429 (1999)
   PUBMED   10412043
REFERENCE   8  (residues 1 to 792)
  AUTHORS   Strahle,U., Schmidt,A., Kelsey,G., Stewart,A.F., Cole,T.J.,
            Schmid,W. and Schutz,G.
  TITLE     At least three promoters direct expression of the mouse
            glucocorticoid receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6731-6735 (1992)
   PUBMED   1495961
REFERENCE   9  (residues 1 to 792)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   10 (residues 1 to 792)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124417.5 and AC007995.23.
            
            On Apr 27, 2018 this sequence version replaced XP_017173324.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.19797.1,
                                           SRR1660819.84205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 21.09 cM"
     Protein         1..792
                     /product="glucocorticoid receptor"
                     /note="glucocorticoid receptor 1; glucocorticoid receptor
                     subtype P"
                     /calculated_mol_wt=87033
     Region          1..436
                     /region_name="Modulating"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            24
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          27..418
                     /region_name="GCR"
                     /note="Glucocorticoid receptor; pfam02155"
                     /db_xref="CDD:426625"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          67..98
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          148..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            168
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            229
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            421
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          433..510
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(437,440,454,457,473,479,489,492)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(447..449,455..456,458..459,462..463,471,486..487,
                     493)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(472..474,476,479..480,484..485,488)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Site            496
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          501..792
                     /region_name="Interaction with CLOCK.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          503..538
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            508
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            510
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            511
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          546..792
                     /region_name="NR_LBD_GR"
                     /note="Ligand binding domain of the glucocorticoid
                     receptor, a member of the nuclear receptor superfamily;
                     cd07076"
                     /db_xref="CDD:132761"
     Region          547..712
                     /region_name="Interaction with CRY1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            order(560,562..566,629..630,640..641,643,645)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132761"
     Site            order(575,578..579,582,585..586,615..616,619..620,623,626,
                     638,657,661,747,750,752)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132761"
     Site            order(590,594,600,604..605,607..608,611..612,767,770..771,
                     773..774,778)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132761"
     CDS             1..792
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /coded_by="NM_001361209.1:117..2495"
                     /db_xref="CCDS:CCDS37791.1"
                     /db_xref="GeneID:14815"
                     /db_xref="MGI:MGI:95824"
ORIGIN      
        1 mdskeslapp grdevpssll grgrgsvmdl yktlrggatv kvsasspsva aasqadskqq
       61 rilldfskgs asnaqqqqqq qqqqqqqqqq qpqpdlskav slsmglymge tetkvmgndl
      121 gypqqgqlgl ssgetdfrll eesianlnrs tsrpenpkss tpaagcatpt ekefpqthsd
      181 psseqqnrks qpgtnggsvk lyttdqstfd ilqdlefsag spgketnesp wrsdlliden
      241 llsplagedd pfllegdvne dckplilpdt kpkiqdtgdt ilsspssval pqvktekddf
      301 ielctpgvik qeklgpvycq asfsgtniig nkmsaisvhg vstsggqmyh ydmntaslsq
      361 qqdqkpvfnv ippipvgsen wnrcqgsged nltslgamnf agrsvfsngy sspgmrpdvs
      421 sppsssstat gpppklclvc sdeasgchyg vltcgsckvf fkravegqhn ylcagrndci
      481 idkirrkncp acryrkclqa gmnlearktk kkikgiqqat agvsqdtsen anktivpaal
      541 pqltptlvsl leviepevly agydssvpds awrimttlnm lggrqviaav kwakaipgfr
      601 nlhlddqmtl lqyswmflma falgwrsyrq asgnllcfap dliineqrmt lpcmydqckh
      661 mlfistelqr lqvsyeeylc mktllllssv pkeglksqel fdeirmtyik elgkaivkre
      721 gnssqnwqrf yqltklldsm hdvvenllsy cfqtfldksm siefpemlae iitnqipkys
      781 ngnikkllfh qk
//
LOCUS       NP_064392                244 aa            linear   ROD 27-AUG-2025
DEFINITION  C-type lectin domain family 7 member A isoform 1 [Mus musculus].
ACCESSION   NP_064392 XP_922942
VERSION     NP_064392.2
DBSOURCE    REFSEQ: accession NM_020008.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 244)
  AUTHORS   Qiu,D., Zhang,S., Huang,C., Wang,X., Deng,J., Sun,H., Feng,B.,
            Tan,Y., Ji,K., Xu,S., Ye,X., Cheng,C., Kakuta,S., Adachi,Y.,
            Iwakura,Y., Wang,S., Dong,S. and Tang,C.
  TITLE     Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis
  JOURNAL   Immunity 58 (7), 1811-1829 (2025)
   PUBMED   40494347
REFERENCE   2  (residues 1 to 244)
  AUTHORS   McKinsey,G.L., Santander,N., Zhang,X., Kleemann,K.L., Tran,L.,
            Katewa,A., Conant,K., Barraza,M., Waddell,K., Lizama,C.O., La
            Russa,M., Koo,J.H., Lee,H., Mukherjee,D., Paidassi,H., Anton,E.S.,
            Atabai,K., Sheppard,D., Butovsky,O. and Arnold,T.D.
  TITLE     Radial glia integrin avb8 regulates cell autonomous microglial
            TGFbeta1 signaling that is necessary for microglial identity
  JOURNAL   Nat Commun 16 (1), 2840 (2025)
   PUBMED   40121230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 244)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   4  (residues 1 to 244)
  AUTHORS   Murphy,B., Miyamoto,T., Manning,B.S., Mirji,G., Ugolini,A.,
            Kannan,T., Hamada,K., Zhu,Y.P., Claiborne,D.T., Huang,L., Zhang,R.,
            Nefedova,Y., Kossenkov,A., Veglia,F., Shinde,R. and Zhang,N.
  TITLE     Myeloid activation clears ascites and reveals IL27-dependent
            regression of metastatic ovarian cancer
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39570374
  REMARK    Erratum:[J Exp Med. 2025 Apr 7;222(4):e2023196702272025c. doi:
            10.1084/jem.2023196702272025c. PMID: 40067151]
REFERENCE   5  (residues 1 to 244)
  AUTHORS   Guibo,L., Chunxu,D., Biao,C., Zhaolei,H., Wenwen,L., Xiangnan,J.,
            Wentao,P., Hongmin,C., Yonghua,L. and Guoqiang,Z.
  TITLE     Dectin-1 participates in the immune-inflammatory response to mouse
            Aspergillus fumigatus keratitis by modulating macrophage
            polarization
  JOURNAL   Front Immunol 15, 1431633 (2024)
   PUBMED   39478855
  REMARK    GeneRIF: Dectin-1 participates in the immune-inflammatory response
            to mouse Aspergillus fumigatus keratitis by modulating macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 244)
  AUTHORS   Brown,G.D., Taylor,P.R., Reid,D.M., Willment,J.A., Williams,D.L.,
            Martinez-Pomares,L., Wong,S.Y. and Gordon,S.
  TITLE     Dectin-1 is a major beta-glucan receptor on macrophages
  JOURNAL   J Exp Med 196 (3), 407-412 (2002)
   PUBMED   12163569
REFERENCE   7  (residues 1 to 244)
  AUTHORS   Brown,G.D. and Gordon,S.
  TITLE     Immune recognition. A new receptor for beta-glucans
  JOURNAL   Nature 413 (6851), 36-37 (2001)
   PUBMED   11544516
REFERENCE   8  (residues 1 to 244)
  AUTHORS   Yokota,K., Takashima,A., Bergstresser,P.R. and Ariizumi,K.
  TITLE     Identification of a human homologue of the dendritic
            cell-associated C-type lectin-1, dectin-1
  JOURNAL   Gene 272 (1-2), 51-60 (2001)
   PUBMED   11470510
REFERENCE   9  (residues 1 to 244)
  AUTHORS   Hermanz-Falcon,P., Arce,I., Roda-Navarro,P. and Fernandez-Ruiz,E.
  TITLE     Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene
            expressed on dendritic cells
  JOURNAL   Immunogenetics 53 (4), 288-295 (2001)
   PUBMED   11491532
  REMARK    Erratum:[Immunogenetics 2001 Aug;53(6):518]
REFERENCE   10 (residues 1 to 244)
  AUTHORS   Ariizumi,K., Shen,G.L., Shikano,S., Xu,S., Ritter,R. 3rd,
            Kumamoto,T., Edelbaum,D., Morita,A., Bergstresser,P.R. and
            Takashima,A.
  TITLE     Identification of a novel, dendritic cell-associated molecule,
            dectin-1, by subtractive cDNA cloning
  JOURNAL   J Biol Chem 275 (26), 20157-20167 (2000)
   PUBMED   10779524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138620.4, BY750022.1, AA240643.1 and AF262985.1.
            
            On May 14, 2008 this sequence version replaced NP_064392.1.
            
            Transcript Variant: This variant (1, coding) represents the longer
            transcript and encodes the longer, functional protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly, except for a single nt from a
            non-reference strain transcript to correct a CDS-truncating
            mutation in the C57BL/6 reference genomic sequence. The genomic
            coordinates used for the transcript record were based on transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF262985.1, BC027742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            polymorphic pseudogene :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.34 cM"
     Protein         1..244
                     /product="C-type lectin domain family 7 member A isoform
                     1"
                     /note="C-type (calcium dependent, carbohydrate recognition
                     domain) lectin, superfamily member 12; dectin-1;
                     DC-associated C-type lectin 1; C-type lectin superfamily
                     member 12; dendritic cell-associated C-type lectin 1;
                     beta-glucan receptor"
                     /calculated_mol_wt=27444
     Region          15..18
                     /region_name="ITAM-like"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     Region          21..41
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     Site            50..70
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     Region          71..113
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     Region          119..242
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(177,205,226,228..229)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     Site            185
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QLQ4.3)"
     CDS             1..244
                     /gene="Clec7a"
                     /gene_synonym="beta-GR; BGR; Clecsf12"
                     /coded_by="NM_020008.4:101..835"
                     /note="isoform 1 is encoded by transcript variant 1,
                     coding"
                     /db_xref="GeneID:56644"
                     /db_xref="MGI:MGI:1861431"
ORIGIN      
        1 mkyhshienl dedgytqldf stqdihkrpr gsekgsqaps spwrpiavgl gilcfvvvvv
       61 aavlgalafw rhnsgrnpee kdnflsrnke nhkptessld ekvapskasq ttggfsqpcl
      121 pnwimhgksc ylfsfsgnsw ygskrhcsql gahllkidns kefefiesqt sshrinafwi
      181 glsrnqsegp wfwedgsaff pnsfqvrnta pqesllhncv wihgsevynq icntssysic
      241 ekel
//
LOCUS       NP_035020                887 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4 isoform 1 [Mus musculus].
ACCESSION   NP_035020 XP_486230
VERSION     NP_035020.2
DBSOURCE    REFSEQ: accession NM_010890.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 887)
  AUTHORS   Windley,S.P., Neirijnck,Y., Vidovic,D., Schwarz,Q., Kumar,S.,
            Nef,S. and Wilhelm,D.
  TITLE     NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell
            Differentiation in the Murine Testis
  JOURNAL   Endocrinology 166 (9) (2025)
   PUBMED   40605617
REFERENCE   2  (residues 1 to 887)
  AUTHORS   Zeng,Q., Guo,H., Tang,N., Renavikar,P.S., Karandikar,N.J.,
            Lovett-Racke,A.E., Racke,M.K., Yan,C., Tang,R., Sinha,S., Ghosh,K.,
            Ryal,J.P., Ouyang,S., Chen,M., Amari,F., Vincenzo,C., Pope,R.M.,
            Li,Y., Yang,H., Langdon,W.Y. and Zhang,J.
  TITLE     K27-linked RORgammat ubiquitination by Nedd4 potentiates
            Th17-mediated autoimmunity
  JOURNAL   J Biomed Sci 32 (1), 26 (2025)
   PUBMED   39972304
  REMARK    Erratum:[J Biomed Sci. 2025 Apr 16;32(1):42. doi:
            10.1186/s12929-025-01136-8. PMID: 40234865]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 887)
  AUTHORS   Fimiani,C., Pereira,J.A., Gerber,J., Berg,I., DeGeer,J.,
            Bachofner,S., Fischer,J.S., Kauffmann,M. and Suter,U.
  TITLE     The E3 ubiquitin ligase Nedd4 fosters developmental myelination in
            the mouse central and peripheral nervous system
  JOURNAL   Glia 73 (2), 422-444 (2025)
   PUBMED   39511974
REFERENCE   4  (residues 1 to 887)
  AUTHORS   Meng,Y., Chen,L., Chai,Y., Meng,W., Yang,G., Ren,J., Li,H., Qi,P.,
            Chen,J. and Wang,N.
  TITLE     PUM2 promoted osteoarthritis progression through PTEN-mediated
            chondrocyte ferroptosis by facilitating NEDD4 mRNA degradation
  JOURNAL   Environ Toxicol 39 (9), 4318-4332 (2024)
   PUBMED   38733337
  REMARK    GeneRIF: PUM2 promoted osteoarthritis progression through
            PTEN-mediated chondrocyte ferroptosis by facilitating NEDD4 mRNA
            degradation.
REFERENCE   5  (residues 1 to 887)
  AUTHORS   Ling,X., Xu,W., Tang,J., Cao,Q., Luo,G., Chen,X., Yang,S.,
            Reinach,P.S. and Yan,D.
  TITLE     The Role of Ubiquitination and the E3 Ligase Nedd4 in Regulating
            Corneal Epithelial Wound Healing
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 29 (2024)
   PUBMED   38888282
  REMARK    GeneRIF: The Role of Ubiquitination and the E3 Ligase Nedd4 in
            Regulating Corneal Epithelial Wound Healing.
REFERENCE   6  (residues 1 to 887)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
REFERENCE   7  (residues 1 to 887)
  AUTHORS   Hatakeyama,S., Jensen,J.P. and Weissman,A.M.
  TITLE     Subcellular localization and ubiquitin-conjugating enzyme (E2)
            interactions of mammalian HECT family ubiquitin protein ligases
  JOURNAL   J Biol Chem 272 (24), 15085-15092 (1997)
   PUBMED   9182527
REFERENCE   8  (residues 1 to 887)
  AUTHORS   Kumar,S., Harvey,K.F., Kinoshita,M., Copeland,N.G., Noda,M. and
            Jenkins,N.A.
  TITLE     cDNA cloning, expression analysis, and mapping of the mouse Nedd4
            gene
  JOURNAL   Genomics 40 (3), 435-443 (1997)
   PUBMED   9073511
  REMARK    Erratum:[Genomics 1997 Aug 15;44(1):156]
REFERENCE   9  (residues 1 to 887)
  AUTHORS   Staub,O., Dho,S., Henry,P., Correa,J., Ishikawa,T., McGlade,J. and
            Rotin,D.
  TITLE     WW domains of Nedd4 bind to the proline-rich PY motifs in the
            epithelial Na+ channel deleted in Liddle's syndrome
  JOURNAL   EMBO J 15 (10), 2371-2380 (1996)
   PUBMED   8665844
REFERENCE   10 (residues 1 to 887)
  AUTHORS   Kumar,S., Tomooka,Y. and Noda,M.
  TITLE     Identification of a set of genes with developmentally
            down-regulated expression in the mouse brain
  JOURNAL   Biochem Biophys Res Commun 185 (3), 1155-1161 (1992)
   PUBMED   1378265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123683.6, AK133838.1, CF736340.1, CO426280.1, CX565415.1 and
            CX566785.1.
            
            On or before Dec 20, 2004 this sequence version replaced
            XP_486230.1, NP_035020.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.20561.1,
                                           SRR9219382.170246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     Protein         1..887
                     /product="E3 ubiquitin-protein ligase NEDD4 isoform 1"
                     /EC_number="2.3.2.26"
                     /note="E3 ubiquitin-protein ligase NEDD4; neural precursor
                     cell expressed developmentally down-regulated protein 4;
                     neural precursor cell expressed, developmentally
                     down-regulated gene 4a; HECT-type E3 ubiquitin transferase
                     NEDD4"
                     /calculated_mol_wt=102576
     Region          79..210
                     /region_name="C2_NEDD4_NEDD4L"
                     /note="C2 domain present in the Human neural precursor
                     cell-expressed, developmentally down-regulated 4 (NEDD4)
                     and NEDD4-like (NEDD4L/NEDD42); cd04033"
                     /db_xref="CDD:175999"
     Site            order(100,152,154,159)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175999"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q62940; propagated from
                     UniProtKB/Swiss-Prot (P46935.3)"
     Region          217..549
                     /region_name="Mediates interaction with TNIK.
                     /evidence=ECO:0000269|PubMed:20159449"
                     /note="propagated from UniProtKB/Swiss-Prot (P46935.3)"
     Region          236..257
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46935.3)"
     Region          254..282
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(266,277)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          271..290
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46935.3)"
     Site            287
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P46935.3)"
     Region          302..322
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46935.3)"
     Site            309
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P46935.3)"
     Region          354..364
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P46934"
                     /note="propagated from UniProtKB/Swiss-Prot (P46935.3)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P46934; propagated from
                     UniProtKB/Swiss-Prot (P46935.3)"
     Site            385
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P46934; propagated from
                     UniProtKB/Swiss-Prot (P46935.3)"
     Region          407..436
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          461..493
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(477,488)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(536,567,578,640,813,848..849,852..856,876,883)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          554..883
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(668,671..672,674..675,678,683,685,689..690,691,697,
                     702,719,723)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..887
                     /gene="Nedd4"
                     /gene_synonym="E430025J12Rik; EG639396; Gm7265; KIAA0093;
                     Nedd4-1; Nedd4a"
                     /coded_by="NM_010890.4:227..2890"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS72275.1"
                     /db_xref="GeneID:17999"
                     /db_xref="MGI:MGI:97297"
ORIGIN      
        1 mssdmaades eapvlsedev wefcldkted gggspgsdvt dtceppcgcw elnpnsleee
       61 hvlftadpyl elhnddtrvv rvkviagigl akkdilgasd pyvrvtlydp msgiltsvqt
      121 ktikkslnpk wneeilfrvl pqrhrilfev fdenrltrdd flgqvdvply plptenprme
      181 rpytfkdfvl hprshksrvk gylrlkmtyl pkngsedena dqaeelepgw vvldqpdaat
      241 hlphppepsp lppgweerqd vlgrtyyvnh esrrtqwkrp spdddltded nddmqlqaqr
      301 afttrrqise dvdgpdnres penweivred enteysgqav qsppsghidv qthlaeefnt
      361 rlavcgnpat sqpvtssnhs srggslqtci feeqptlpvl lptssglppg weekqddrgr
      421 syyvdhnskt ttwskptmqd dprskipahl rgktdsndlg plppgweert htdgrvffin
      481 hnikktqwed prlqnvaitg pavpysrdyk rkyeffrrkl kkqtdipnkf emklrranil
      541 edsyrrimgv kradllkarl wiefdgekgl dyggvarewf fliskemfnp yyglfeysat
      601 dnytlqinpn sglcnedhls yfkfigrvag mavyhgklld gffirpfykm mlqklitlhd
      661 mesvdseyys slrwilendp teldlrfiid eelfgqthqh elktggseiv vtnknkkeyi
      721 ylviqwrfvn riqkqmaafk egffelipqd likifdenel ellmcglgdv dvndwrehtk
      781 ykngysmnhq vihwfwkavw mmdsekrirl lqfvtgtsrv pmngfaelyg sngpqsftve
      841 qwgtpdklpr ahtcfnrldl ppyesfdelw dklqmaient qgfdgvd
//
LOCUS       NP_001155315             372 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-18 receptor 1 isoform b precursor [Mus musculus].
ACCESSION   NP_001155315
VERSION     NP_001155315.1
DBSOURCE    REFSEQ: accession NM_001161843.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Shen,J., Zhang,Y., Tang,W., Yang,M., Cheng,T., Chen,Y., Yu,S.,
            Guo,Q., Cao,L., Wang,X., Xiao,H., Wang,L., Wang,C., Liu,C.Y. and
            Meng,G.
  TITLE     Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to
            suppress tumor growth
  JOURNAL   Nat Immunol 26 (3), 416-428 (2025)
   PUBMED   39891018
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Zhang,X., Li,S., Lason,W., Greco,M., Klenerman,P. and Hinks,T.S.C.
  TITLE     MAIT cells protect against sterile lung injury
  JOURNAL   Cell Rep 44 (2), 115275 (2025)
   PUBMED   39918959
REFERENCE   3  (residues 1 to 372)
  AUTHORS   McManus,R.M., Komes,M.P., Griep,A., Santarelli,F., Schwartz,S.,
            Ramon Perea,J., Schlachetzki,J.C.M., Bouvier,D.S., Khalil,M.A.,
            Lauterbach,M.A., Heinemann,L., Schluter,T., Pour,M.S., Lovotti,M.,
            Stahl,R., Duthie,F., Rodriguez-Alcazar,J.F., Schmidt,S.V.,
            Spitzer,J., Noori,P., Maillo,A., Boettcher,A., Herron,B.,
            McConville,J., Gomez-Cabrero,D., Tegner,J., Glass,C.K., Hiller,K.,
            Latz,E. and Heneka,M.T.
  TITLE     NLRP3-mediated glutaminolysis controls microglial phagocytosis to
            promote Alzheimer's disease progression
  JOURNAL   Immunity 58 (2), 326-343 (2025)
   PUBMED   39904338
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Slusny,B., Zimmer,V., Nasiri,E., Lutz,V., Huber,M., Buchholz,M.,
            Gress,T.M., Roth,K. and Bauer,C.
  TITLE     Optimized Spheroid Model of Pancreatic Cancer Demonstrates
            Influence of Macrophage-T Cell Interaction for Intratumoral T Cell
            Motility
  JOURNAL   Cancers (Basel) 17 (1), 51 (2024)
   PUBMED   39796680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Sergi,B. and Penttila,I.
  TITLE     Interleukin 18 receptor
  JOURNAL   J Biol Regul Homeost Agents 18 (1), 55-61 (2004)
   PUBMED   15323361
  REMARK    GeneRIF: review of structure, function and tissue distribution of
            IL-18R [review]
            Review article
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Seki,E., Tsutsui,H., Tsuji,N.M., Hayashi,N., Adachi,K., Nakano,H.,
            Futatsugi-Yumikura,S., Takeuchi,O., Hoshino,K., Akira,S.,
            Fujimoto,J. and Nakanishi,K.
  TITLE     Critical roles of myeloid differentiation factor 88-dependent
            proinflammatory cytokine release in early phase clearance of
            Listeria monocytogenes in mice
  JOURNAL   J Immunol 169 (7), 3863-3868 (2002)
   PUBMED   12244183
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Okamoto,M., Kato,S., Oizumi,K., Kinoshita,M., Inoue,Y., Hoshino,K.,
            Akira,S., McKenzie,A.N., Young,H.A. and Hoshino,T.
  TITLE     Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung
            injury in mice: a potential role for cytokines, chemokines, and
            natural killer cells in the pathogenesis of interstitial pneumonia
  JOURNAL   Blood 99 (4), 1289-1298 (2002)
   PUBMED   11830478
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167126.6.
            
            Transcript Variant: This variant (3) uses an alternate splice
            pattern in the 5' UTR and 5' coding region, compared to variant 1.
            The resulting isoform (b) has a shorter and distinct C-terminus,
            compared to isoform a. Both variants 2 and 3 encode the same
            isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023240.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.27 cM"
     Protein         1..372
                     /product="interleukin-18 receptor 1 isoform b precursor"
                     /EC_number="3.2.2.6"
                     /note="interleukin 1 receptor related protein; IL-18R1;
                     IL-1Rrp; IL1R-rp; IL-18R-1; IL-18Ralpha; IL1
                     receptor-related protein; CD218 antigen-like family member
                     A; IL-18R-alpha; interleukin-18 receptor alpha"
                     /calculated_mol_wt=40414
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2151
     Region          3..>98
                     /region_name="Ig_6"
                     /note="Immunoglobulin domain; pfam18452"
                     /db_xref="CDD:465773"
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            71
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            107
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            111
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          131..205
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          137..141
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409415"
     Region          149..156
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409415"
     Region          <157..257
                     /region_name="PHA02785"
                     /note="IL-beta-binding protein; Provisional"
                     /db_xref="CDD:165149"
     Region          179..184
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409415"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409415"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          212..312
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          230..234
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409526"
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          243..246
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409526"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409526"
     Region          293..298
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409526"
     Site            295
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          306..309
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409526"
     Site            327..347
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61098.1)"
     CDS             1..372
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /coded_by="NM_001161843.1:328..1446"
                     /note="isoform b precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS48247.1"
                     /db_xref="GeneID:16182"
                     /db_xref="MGI:MGI:105383"
ORIGIN      
        1 mhheeliltl cilivksask scihrsqihv vegepfylkp cgisapvhrn etatmrwfkg
       61 sasheyreln nrssprvtfh dhtlefwpve medegtyisq vgndrrnwtl nvtkrnkhsc
      121 fsdklvtsrd vevnkslhit cknpnyeeli qdtwlyknck eisktprilk daefgdegyy
      181 scvfsvhhng trynitktvn itviegrskv tpailgpkce kvgvelgkdv elncsaslnk
      241 ddlfywsirk edssdpnvqe drketttwis egklhaskil rfqkitenyl nvlynctvan
      301 eeaidtksfv lvrkeipdip ghvftggvtv lvlasvaavc ivilcviykv dlvlfyrria
      361 erdetltgnm ll
//
LOCUS       NP_898852                357 aa            linear   ROD 27-AUG-2025
DEFINITION  G-protein coupled receptor 183 [Mus musculus].
ACCESSION   NP_898852
VERSION     NP_898852.2
DBSOURCE    REFSEQ: accession NM_183031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 357)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 357)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell 188 (4), 1019-1035 (2025)
   PUBMED   39708807
REFERENCE   3  (residues 1 to 357)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 357)
  AUTHORS   Fessler,M.B., Madenspacher,J.H., Baker,P.J., Hilligan,K.L.,
            Bohrer,A.C., Castro,E., Meacham,J., Chen,S.H., Johnson,R.F.,
            McDonald,J.G., Martin,N.P., Tucker,C.J., Mahapatra,D., Cesta,M. and
            Mayer-Barber,K.D.
  TITLE     Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early
            SARS-CoV-2 Pathogenesis in Mice
  JOURNAL   Am J Respir Cell Mol Biol 69 (6), 638-648 (2023)
   PUBMED   37578898
REFERENCE   5  (residues 1 to 357)
  AUTHORS   Zhang,F., Zhang,B., Ding,H., Li,X., Wang,X., Zhang,X., Liu,Q.,
            Feng,Q., Han,M., Chen,L., Qi,L., Yang,D., Li,X., Zhu,X., Zhao,Q.,
            Qiu,J., Zhu,Z., Tang,H., Shen,N., Wang,H. and Wei,B.
  TITLE     The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to
            Limit IFN Response and Systemic Lupus Erythematosus
  JOURNAL   Adv Sci (Weinh) 10 (27), e2207108 (2023)
   PUBMED   37469011
  REMARK    GeneRIF: The Oxysterol Receptor EBI2 Links Innate and Adaptive
            Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
REFERENCE   6  (residues 1 to 357)
  AUTHORS   Pereira,J.P., Kelly,L.M., Xu,Y. and Cyster,J.G.
  TITLE     EBI2 mediates B cell segregation between the outer and centre
            follicle
  JOURNAL   Nature 460 (7259), 1122-1126 (2009)
   PUBMED   19597478
  REMARK    GeneRIF: important role for EBI2 in promoting B cell localization
            in the outer follicle, and show that differential expression of
            this receptor helps position B cells appropriately for mounting
            T-dependent antibody responses
REFERENCE   7  (residues 1 to 357)
  AUTHORS   Gatto,D., Paus,D., Basten,A., Mackay,C.R. and Brink,R.
  TITLE     Guidance of B cells by the orphan G protein-coupled receptor EBI2
            shapes humoral immune responses
  JOURNAL   Immunity 31 (2), 259-269 (2009)
   PUBMED   19615922
  REMARK    GeneRIF: EBI2 provides a previously uncharacterized dimension to B
            cell migration that is crucial for coordinating rapid versus
            long-term antibody responses.
REFERENCE   8  (residues 1 to 357)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   9  (residues 1 to 357)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (residues 1 to 357)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138693.1, AK141593.1 and BB525541.2.
            
            On Feb 25, 2006 this sequence version replaced NP_898852.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY219549.1, AK156005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 65.86 cM"
     Protein         1..357
                     /product="G-protein coupled receptor 183"
                     /note="EBV-induced G-protein coupled receptor 2 homolog;
                     Epstein-Barr virus induced gene 2; epstein-Barr
                     virus-induced G-protein coupled receptor 2 homolog"
                     /calculated_mol_wt=40054
     Site            4
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          28..315
                     /region_name="7tmA_EBI2"
                     /note="Epstein-Barr virus (EBV)-induced gene 2, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15159"
                     /db_xref="CDD:320287"
     Region          28..55
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320287"
     Site            28..53
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          62..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320287"
     Site            74..91
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Site            order(83,86..87,100..105,107..108,111,156,158..162,189,
                     192..194,196..198,200..201,253,256..257,259..260,263,
                     282..283,285..287,290,293..294)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320287"
     Region          100..130
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320287"
     Site            102..123
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          122..130
                     /region_name="Interaction with G proteins.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          142..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320287"
     Site            146..164
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          189..218
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320287"
     Site            189..211
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          233..263
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320287"
     Site            238..261
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          283..308
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320287"
     Site            284..308
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Region          336..357
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U6B2.1)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q3U6B2.1)"
     CDS             1..357
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /coded_by="NM_183031.2:166..1239"
                     /db_xref="CCDS:CCDS27343.1"
                     /db_xref="GeneID:321019"
                     /db_xref="MGI:MGI:2442034"
ORIGIN      
        1 mannfttpla tshgnncdly ahhstarvlm plhyslvfii glvgnllalv vivqnrkkin
       61 sttlysmnlv isdilfttal ptriayyalg fdwrigdalc rvtalvfyin tyagvnfmtc
      121 lsidrffavv hplrynkikr ieyakgvcls vwilvfaqtl pllltpmske egdkttcmey
      181 pnfegtaslp willgacllg yvlpitvill cysqiccklf rtakqnplte ksgvnkkaln
      241 tiiliivvfi lcftpyhvai iqhmikmlcs pgalecgarh sfqislhftv clmnfnccmd
      301 pfiyffackg ykrkvmkmlk rqvsvsissa vrsapeensr emtesqmmih skasngr
//
LOCUS       NP_062713                652 aa            linear   ROD 27-AUG-2025
DEFINITION  forkhead box protein O1 [Mus musculus].
ACCESSION   NP_062713
VERSION     NP_062713.2
DBSOURCE    REFSEQ: accession NM_019739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 652)
  AUTHORS   Baldwin,H.S., Davis,M.J., Harmelink,C. and Qu,X.
  TITLE     TIE1-dependent lymphatic vascular remodeling is mediated by its
            second tyrosine kinase domain
  JOURNAL   Development 152 (13) (2025)
   PUBMED   40539480
REFERENCE   2  (residues 1 to 652)
  AUTHORS   Hsu,P., Choi,E.J., Wong,W.H., Lin,Y.H., Vandenburgh,S.A., Liu,Y.C.,
            Yao,P., Indralingam,C.S., Yeo,G.W., Zuniga,E.I., Goldrath,A.W.,
            Wang,W. and Chang,J.T.
  TITLE     Foxo1 regulates intestinal tissue-resident memory CD8 T cell
            biology in an anatomic compartment- and context-specific manner
  JOURNAL   Sci Immunol 10 (106), eadn1894 (2025)
   PUBMED   40215325
REFERENCE   3  (residues 1 to 652)
  AUTHORS   Garcia-Gonzalez,I., Gambera,S., Rocha,S.F., Regano,A.,
            Garcia-Ortega,L., Lytvyn,M., Diago-Domingo,L., Sanchez-Munoz,M.S.,
            Garcia-Cabero,A., Zagorac,I., Luo,W., De Andres-Laguillo,M.,
            Fernandez-Chacon,M., Casquero-Garcia,V., Lunella,F.F., Torroja,C.,
            Sanchez-Cabo,F. and Benedito,R.
  TITLE     iFlpMosaics enable the multispectral barcoding and high-throughput
            comparative analysis of mutant and wild-type cells
  JOURNAL   Nat Methods 22 (2), 323-334 (2025)
   PUBMED   39672980
REFERENCE   4  (residues 1 to 652)
  AUTHORS   Mesquita,T., Miguel-Dos-Santos,R., Liu,W., Fournier,M.,
            Rogers,R.G., Alfaro,J., Nawaz,A., Sanchez,L., Jones,X.M., Li,L.,
            Marban,E. and Cingolani,E.
  TITLE     Upregulated FoxO1 promotes arrhythmogenesis in mice with heart
            failure and preserved ejection fraction
  JOURNAL   Nat Commun 16 (1), 1184 (2025)
   PUBMED   39885127
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 652)
  AUTHORS   He,Z., Yan,R.G., Shang,Q.B. and Yang,Q.E.
  TITLE     Transcriptomic dynamics and cell-to-cell communication during the
            transition of prospermatogonia to spermatogonia revealed at
            single-cell resolution
  JOURNAL   BMC Genomics 26 (1), 58 (2025)
   PUBMED   39838296
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 652)
  AUTHORS   Nakae,J., Kitamura,T., Silver,D.L. and Accili,D.
  TITLE     The forkhead transcription factor Foxo1 (Fkhr) confers insulin
            sensitivity onto glucose-6-phosphatase expression
  JOURNAL   J Clin Invest 108 (9), 1359-1367 (2001)
   PUBMED   11696581
REFERENCE   7  (residues 1 to 652)
  AUTHORS   Biggs,W.H. 3rd, Cavenee,W.K. and Arden,K.C.
  TITLE     Identification and characterization of members of the FKHR (FOX O)
            subclass of winged-helix transcription factors in the mouse
  JOURNAL   Mamm Genome 12 (6), 416-425 (2001)
   PUBMED   11353388
REFERENCE   8  (residues 1 to 652)
  AUTHORS   Anderson,M.J., Shelton,G.D., Cavenee,W.K. and Arden,K.C.
  TITLE     Embryonic expression of the tumor-associated PAX3-FKHR fusion
            protein interferes with the developmental functions of Pax3
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1589-1594 (2001)
   PUBMED   11171995
REFERENCE   9  (residues 1 to 652)
  AUTHORS   Furuyama,T., Nakazawa,T., Nakano,I. and Mori,N.
  TITLE     Identification of the differential distribution patterns of mRNAs
            and consensus binding sequences for mouse DAF-16 homologues
  JOURNAL   Biochem J 349 (Pt 2), 629-634 (2000)
   PUBMED   10880363
REFERENCE   10 (residues 1 to 652)
  AUTHORS   Nakae,J., Park,B.C. and Accili,D.
  TITLE     Insulin stimulates phosphorylation of the forkhead transcription
            factor FKHR on serine 253 through a Wortmannin-sensitive pathway
  JOURNAL   J Biol Chem 274 (23), 15982-15985 (1999)
   PUBMED   10347145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104932.22 and AC163092.4.
            
            On Aug 28, 2003 this sequence version replaced NP_062713.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ252157.1, AK154041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 23.19 cM"
     Protein         1..652
                     /product="forkhead box protein O1"
                     /note="forkhead protein 1; forkhead box protein O1A;
                     forkhead in rhabdomyosarcoma; forkhead box O1a"
                     /calculated_mol_wt=69388
     Region          1..62
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKB/AKT1 or PKB/AKT2 and SGK1.
                     /evidence=ECO:0000269|PubMed:10347145,
                     ECO:0000269|PubMed:19965929, ECO:0000269|PubMed:20519497;
                     propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          112..154
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          148..246
                     /region_name="FH_FOXO1"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     O1 (FOXO1); cd20060"
                     /db_xref="CDD:410834"
     Site            order(154..155,157,161..162,180..181,184,208..209,
                     211..212,215,222,229,231..232,234)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410834"
     Site            155
                     /site_type="DNA binding"
                     /note="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            162
                     /site_type="DNA binding"
                     /note="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          208..215
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q12778"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by STK4/MST1.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            222
                     /site_type="DNA binding"
                     /note="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          231..342
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          231..234
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q12778"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            232
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            242
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15220471,
                     ECO:0000269|PubMed:16076959, ECO:0000269|PubMed:17090532;
                     propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            245
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15220471,
                     ECO:0000269|PubMed:16076959, ECO:0000269|PubMed:17090532;
                     propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            246
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          248..250
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            248
                     /site_type="methylation"
                     /note="Omega-N-methylarginine, by PRMT1.
                     /evidence=ECO:0000269|PubMed:18951090; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            250
                     /site_type="methylation"
                     /note="Omega-N-methylarginine, by PRMT1.
                     /evidence=ECO:0000269|PubMed:18951090; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            253
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1 and SGK1.
                     /evidence=ECO:0000269|PubMed:10347145,
                     ECO:0000269|PubMed:16076959, ECO:0000269|PubMed:18388859,
                     ECO:0000269|PubMed:19965929, ECO:0000269|PubMed:20519497,
                     ECO:0000269|PubMed:27827363; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            259
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            262
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15220471,
                     ECO:0000269|PubMed:16076959, ECO:0000269|PubMed:17090532;
                     propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            271
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          280..562
                     /region_name="Sufficient for interaction with NLK.
                     /evidence=ECO:0000269|PubMed:20061393"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            316
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1 or PKB/AKT2.
                     /evidence=ECO:0000269|PubMed:10347145; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1 and SGK1.
                     /evidence=ECO:0000269|PubMed:19965929; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            322
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            326
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Site            330
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          360..456
                     /region_name="Required for interaction with RUNX2.
                     /evidence=ECO:0000269|PubMed:21471200"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          383..410
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          420..501
                     /region_name="FOXO_KIX_bdg"
                     /note="KIX-binding domain of forkhead box O, CR2;
                     pfam16675"
                     /db_xref="CDD:465228"
     Site            420
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12778; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          459..463
                     /region_name="Required for interaction with SIRT1.
                     /evidence=ECO:0000269|PubMed:15220471"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E0.2)"
     Region          594..630
                     /region_name="FOXO-TAD"
                     /note="Transactivation domain of FOXO protein family;
                     pfam16676"
                     /db_xref="CDD:435506"
     CDS             1..652
                     /gene="Foxo1"
                     /gene_synonym="Afxh; FKHR; Fkhr1; Foxo1a"
                     /coded_by="NM_019739.3:466..2424"
                     /db_xref="CCDS:CCDS17343.1"
                     /db_xref="GeneID:56458"
                     /db_xref="MGI:MGI:1890077"
ORIGIN      
        1 maeapqvvet dpdfeplprq rsctwplprp efnqsnstts spapsggaaa npdaaaslas
       61 asavstdfms nlslleesed farapgcvav aaaaaasrgl cgdfqgpeag cvhpappqpp
      121 ptgplsqppp vppsaaaaag plagqprkts ssrrnawgnl syadlitkai essaekrltl
      181 sqiyewmvks vpyfkdkgds nssagwknsi rhnlslhskf irvqnegtgk sswwmlnpeg
      241 gksgksprrr aasmdnnskf aksrgraakk kaslqsgqeg pgdspgsqfs kwpaspgshs
      301 nddfdnwstf rprtssnast isgrlspimt eqddlgdgdv hslvyppsaa kmastlpsls
      361 eisnpenmen lldnlnllss ptsltvstqs spgsmmqqtp cysfappnts lnspspnysk
      421 ytygqssmsp lpqmpmqtlq dskssyggln qyncapgllk elltsdspph ndimspvdpg
      481 vaqpnsrvlg qnvmmgpnsv mpaygsqash nkmmnpssht hpghaqqtas vngrtlphvv
      541 ntmphtsamn rltpvktplq vplshpmqms algsyssvss cngygrmgvl hqeklpsdld
      601 gmfierldcd mesiirndlm dgdtldfnfd nvlpnqsfph svkttthswv sg
//
LOCUS       NP_001273977             290 aa            linear   ROD 27-AUG-2025
DEFINITION  pituitary homeobox 2 isoform e [Mus musculus].
ACCESSION   NP_001273977
VERSION     NP_001273977.1
DBSOURCE    REFSEQ: accession NM_001287048.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   4  (residues 1 to 290)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J 292 (4), 851-863 (2025)
   PUBMED   39704783
REFERENCE   5  (residues 1 to 290)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   6  (residues 1 to 290)
  AUTHORS   Lamba,P., Hjalt,T.A. and Bernard,D.J.
  TITLE     Novel forms of Paired-like homeodomain transcription factor 2
            (PITX2): generation by alternative translation initiation and mRNA
            splicing
  JOURNAL   BMC Mol Biol 9, 31 (2008)
   PUBMED   18373856
  REMARK    GeneRIF: identification & characterization of 2 novel isoforms of
            PITX2, generated by alternative translation initiation (PITX2Cbeta)
            & alternative mRNA splicing (PITX2B2); they show similar DNA
            binding & trans-activation functions as other PITX2 isoforms in
            vitro
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 290)
  AUTHORS   Phillips,J.C., del Bono,E.A., Haines,J.L., Pralea,A.M., Cohen,J.S.,
            Greff,L.J. and Wiggs,J.L.
  TITLE     A second locus for Rieger syndrome maps to chromosome 13q14
  JOURNAL   Am J Hum Genet 59 (3), 613-619 (1996)
   PUBMED   8751862
REFERENCE   8  (residues 1 to 290)
  AUTHORS   Heon,E., Sheth,B.P., Kalenak,J.W., Sunden,S.L., Streb,L.M.,
            Taylor,C.M., Alward,W.L., Sheffield,V.C. and Stone,E.M.
  TITLE     Linkage of autosomal dominant iris hypoplasia to the region of the
            Rieger syndrome locus (4q25)
  JOURNAL   Hum Mol Genet 4 (8), 1435-1439 (1995)
   PUBMED   7581385
REFERENCE   9  (residues 1 to 290)
  AUTHORS   Sanz,L., Moscat,J. and Diaz-Meco,M.T.
  TITLE     Molecular characterization of a novel transcription factor that
            controls stromelysin expression
  JOURNAL   Mol Cell Biol 15 (6), 3164-3170 (1995)
   PUBMED   7760812
REFERENCE   10 (residues 1 to 290)
  AUTHORS   Murray,J.C., Bennett,S.R., Kwitek,A.E., Small,K.W., Schinzel,A.,
            Alward,W.L., Weber,J.L., Bell,G.I. and Buetow,K.H.
  TITLE     Linkage of Rieger syndrome to the region of the epidermal growth
            factor gene on chromosome 4
  JOURNAL   Nat Genet 2 (1), 46-49 (1992)
   PUBMED   1303248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB626986.1, BC075660.1 and AV306733.1.
            
            Transcript Variant: This variant (3) contains an alternate 5'
            terminal exon, lacks a portion of the 5' coding region and
            initiates translation at an alternate start codon compared to
            variant 1. The encoded protein (isoform e, also known as
            PITX2Cbeta) has a distinct N-terminus and is longer than isoform a.
            Translation begins at a downstream in-frame start codon compared to
            the AUG used in this transcript to produce PITX2Calpha (PMID
            18373856).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF048724.1, BC075660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:18373856)
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 57.84 cM"
     Protein         1..290
                     /product="pituitary homeobox 2 isoform e"
                     /note="pituitary homeobox 2; solurshin; BRX1 homeoprotein;
                     ALL1-responsive protein ARP1; orthodenticle-like homeobox
                     2; paired-like homeodomain transcription factor Munc 30;
                     bicoid-related homeobox protein 1"
                     /calculated_mol_wt=32084
     Region          59..115
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          248..265
                     /region_name="OAR"
                     /note="OAR motif; pfam03826"
                     /db_xref="CDD:461067"
     CDS             1..290
                     /gene="Pitx2"
                     /gene_synonym="9430085M16Rik; Brx1; Brx1b; Munc30; Otlx2;
                     Ptx2; Rieg"
                     /coded_by="NM_001287048.1:748..1620"
                     /note="isoform e is encoded by transcript variant 3"
                     /db_xref="GeneID:18741"
                     /db_xref="MGI:MGI:109340"
ORIGIN      
        1 masvlapgqp rsldsskhrl evhtisdtss pevaekdkgq qgknedvgae dpskkkrqrr
       61 qrthftsqql qeleatfqrn rypdmstree iavwtnltea rvrvwfknrr akwrkrernq
      121 qaelckngfg pqfnglmqpy ddmypgysyn nwaakgltsa slstksfpff nsmnvnplss
      181 qsmfsppnsi ssmsmsssmv psavtgvpgs slnslnnlnn lsspslnsav ptpacpyapp
      241 tppyvyrdtc nsslaslrlk akqhssfgya svqnpasnls acqyavdrpv
//
LOCUS       NP_001389666            2741 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 11 [Mus musculus].
ACCESSION   NP_001389666 XP_036016840
VERSION     NP_001389666.1
DBSOURCE    REFSEQ: accession NM_001402737.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2741)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2741)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2741)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2741)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2741)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2741)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2741)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2741)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2741)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2741)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Mar 21, 2022 this sequence version replaced XP_036016840.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.867525.1,
                                           SRR17253013.4715205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2741
                     /product="adenomatous polyposis coli protein isoform 11"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=299543
     Region          4..55
                     /region_name="APC_N_CC"
                     /note="Coiled-coil N-terminus of APC, dimerization domain;
                     pfam16689"
                     /db_xref="CDD:435517"
     Region          125..205
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          <305..363
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          356..407
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          362..405
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(396,400,404,439,443,447,483,487,491)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          409..450
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          413..450
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          457..492
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          500..541
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          546..586
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          550..584
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          588..628
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          592..628
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          629..916
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          933..1032
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1154..>1171
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1180..1266
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1534..1557
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1559..1612
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1613..1634
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1643..1736
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1770..1844
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          1931..1950
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2122..2467
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2569..2741
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2741
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001402737.1:60..8285"
                     /note="isoform 11 is encoded by transcript variant 14"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 maaasydqll kqvealkmen snlrqeledn snhltklete asnmkevlkq lqgsiedetm
       61 tsgqidller lkefnldsnf pgvklrskms lrsygsregs vssrsgecsp vpmgsfprrt
      121 fvngsrestg yleelekers llladldkee kekdwyyaql qnltkridsl pltenfslqt
      181 dmtrrqleye arqiraamee qlgtcqdmek raqrriariq qiekdilrvr qllqsqaaea
      241 erssqsrhda asheagrqhe ghgvaesnta asssgqspat rvdhetasvl sssgthsapr
      301 rltshlgtki raycetcwew qeaheqgmdq dknpmpapve hqicpavcvl mklsfdeehr
      361 hamnelgglq aiaellqvdc emygltndhy svtlrryagm altnltfgdv ankatlcsmk
      421 gcmralvaql ksesedlqqv iasvlrnlsw radvnskktl revgsvkalm ecalevkkes
      481 tlksvlsalw nlsahctenk adicavdgal aflvgtltyr sqtntlaiie sgggilrnvs
      541 sliatnedhr qilrennclq tllqhlkshs ltivsnacgt lwnlsarnpk dqealwdmga
      601 vsmlknlihs khkmiamgsa aalrnlmanr pakykdanim spgsslpslh vrkqkaleae
      661 ldaqhlsetf dnidnlspka shrskqrhkq nlygdyafda nrhddsrsdn fntgnmtvls
      721 pylnttvlps ssssrgslds srsekdrsle rergiglsay hpttenagts skrglqittt
      781 aaqiakvmee vsaihtsqdd rssasttefh cvaddrsaar rssashthsn tynftksens
      841 nrtcsmpyak veykrssnds lnsvtssdgy gkrgqmkpsv esyseddesk fcsygqypad
      901 lahkihsanh mddndgeldt pinyslkysd eqlnsgrqsp sqnerwarpk hviedeikqn
      961 eqrqarsqnt sypvysentd dkhlkfqphf gqqecvspyr srgtsgsetn rmgsshainq
     1021 nvnqslcqed dyeddkptny seryseeeqh eeeeerptny sikyneekhh vdqpidyslk
     1081 yatdisssqk psfsfsknss aqstkpehls pssentavpp snakrqnqlr pssaqrngqt
     1141 qkgttckvps inqetiqtyc vedtpicfsr csslsslssa ddeigcdqtt qeadsantlq
     1201 taevkendvt rsaedpatev pavsqnarak psrlqasgls sestrhnkav efssgaksps
     1261 ksgaqtpksp pehyvqetpl vfsrctsvss ldsfesrsia ssvqsepcsg mvsgiispsd
     1321 lpdspgqtmp psrsktpppp pqtvqakrev pkskvpaaek resgpkqtav naavqrvqvl
     1381 pdvdtllhfa testpdgfsc ssslsalsld epfiqkdvel rimppvqend ngneteseqp
     1441 eesnenqdke vekpdsekdl lddsddddie ileeciisam ptkssrkakk laqtasklpp
     1501 pvarkpsqlp vykllpaqnr lqaqkhvsft pgddvprvyc vegtpinfst atslsdltie
     1561 sppnelatgd gvragiqsge fekrdtipte grstddaqrg kissivtpdl ddnkaeegdi
     1621 laecinsamp kgkshkpfrv kkimdqvqqa sstssgankn qvdtkkkkpt spvkpmpqnt
     1681 eyrtrvrknt dskvnvntee tfsdnkdskk pslqtnakaf neklpnnedr vrgsfaldsp
     1741 hhytpiegtp ycfsrndsls sldfddddvd lsrekaelrk gkeskdseak vtcrpepnss
     1801 qqaasksqas ikhpanraqs kpvlqkqptf pqsskdgpdr gaatdeklqn faientpvcf
     1861 srnsslssls didqennnnk esepikeaep ansqgepskp qasgyapksf hvedtpvcfs
     1921 rnsslsslsi dseddllqec issampkkkr psrlksesek qsprkvggil aedltldlkd
     1981 lqrpdsehaf spdsenfdwk aiqegansiv sslhqaaaaa aclsrqassd sdsilslksg
     2041 islgspfhlt pdqeekpfts nkgprilkpg ekstleakki esenkgikgg kkvykslitg
     2101 kirsnseiss qmkqplptnm psisrgrtmi hipglrnsss stspvskkgp plktpasksp
     2161 segpgattsp rgtkpagkse lspitrqtsq isgsnkgssr sgsrdstpsr ptqqplsrpm
     2221 qspgrnsisp grngisppnk lsqlprtssp stastkssgs gkmsytspgr qlsqqnltkq
     2281 aslsknassi prsesaskgl nqmsngngsn kkvelsrmss tkssgsesdr serpalvrqs
     2341 tfikeapspt lrrkleesas feslspssrp dsptrsqaqt pvlspslpdm slsthpsvqa
     2401 ggwrklppnl sptieyndgr ptkrhdiars hsespsrlpi nragtwkreh skhssslprv
     2461 stwrrtgsss silsassess ekaksederh vssmpaprqm kenqvptkgt wrkikesdis
     2521 ptgmasqsas sgaasgaesk pliyqmappv sktedvwvri edcpinnprs grsptgntpp
     2581 vidsvsekgs ssikdskdth gkqsvgsgsp vqtvgletrl nsfvqveape qkgteakpgq
     2641 snpvsiaeta etciaertpf sssssskhss psgtvaarvt pfnynpsprk ssadstsarp
     2701 sqiptpvstn tkkrdsktds tessgaqspk rhsgsylvts v
//
LOCUS       NP_080248                362 aa            linear   ROD 27-AUG-2025
DEFINITION  N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_080248
VERSION     NP_080248.2
DBSOURCE    REFSEQ: accession NM_025972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Fotio,Y., Mabou Tagne,A., Squire,E., Lee,H.L., Phillips,C.M.,
            Chang,K., Ahmed,F., Greenberg,A.S., Villalta,S.A., Scarfone,V.M.,
            Spadoni,G., Mor,M. and Piomelli,D.
  TITLE     NAAA-regulated lipid signaling in monocytes controls the induction
            of hyperalgesic priming in mice
  JOURNAL   Nat Commun 15 (1), 1705 (2024)
   PUBMED   38402219
  REMARK    GeneRIF: NAAA-regulated lipid signaling in monocytes controls the
            induction of hyperalgesic priming in mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Li,Y., Li,Y., Xu,S., Chen,Y., Zhou,P., Hu,T., Li,H., Liu,Y., Xu,Y.,
            Ren,J., Qiu,Y. and Lu,C.
  TITLE     N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis
            inflammation by enhancing dendritic cell (DCs) maturation
  JOURNAL   Pharmacol Res 185, 106491 (2022)
   PUBMED   36244543
  REMARK    Erratum:[Pharmacol Res. 2022 Nov;185:106527. doi:
            10.1016/j.phrs.2022.106527. PMID: 36328902]
REFERENCE   4  (residues 1 to 362)
  AUTHORS   Palese,F., Pontis,S., Realini,N., Torrens,A., Ahmed,F., Assogna,F.,
            Pellicano,C., Bossu,P., Spalletta,G., Green,K. and Piomelli,D.
  TITLE     Targeting NAAA counters dopamine neuron loss and symptom
            progression in mouse models of parkinsonism
  JOURNAL   Pharmacol Res 182, 106338 (2022)
   PUBMED   35781057
REFERENCE   5  (residues 1 to 362)
  AUTHORS   Xie,X., Li,Y., Xu,S., Zhou,P., Yang,L., Xu,Y., Qiu,Y., Yang,Y. and
            Li,Y.
  TITLE     Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid
            Ethanolamides (FAEs) Metabolism and Inflammatory Responses
  JOURNAL   Front Pharmacol 12, 817603 (2022)
   PUBMED   35069223
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 362)
  AUTHORS   Alhouayek,M., Bottemanne,P., Subramanian,K.V., Lambert,D.M.,
            Makriyannis,A., Cani,P.D. and Muccioli,G.G.
  TITLE     N-Acylethanolamine-hydrolyzing acid amidase inhibition increases
            colon N-palmitoylethanolamine levels and counteracts murine colitis
  JOURNAL   FASEB J 29 (2), 650-661 (2015)
   PUBMED   25384424
  REMARK    GeneRIF: NAAA inhibition increases palmitoylethanolamide levels in
            the colon and reduces colon inflammation and systemic inflammation
REFERENCE   7  (residues 1 to 362)
  AUTHORS   Sasso,O., Moreno-Sanz,G., Martucci,C., Realini,N., Dionisi,M.,
            Mengatto,L., Duranti,A., Tarozzo,G., Tarzia,G., Mor,M.,
            Bertorelli,R., Reggiani,A. and Piomelli,D.
  TITLE     Antinociceptive effects of the N-acylethanolamine acid amidase
            inhibitor ARN077 in rodent pain models
  JOURNAL   Pain 154 (3), 350-360 (2013)
   PUBMED   23218523
  REMARK    GeneRIF: NAAA regulates peripheral pain initiation by interrupting
            endogenous fatty acid ethanolamide signaling at PPAR-alpha.
REFERENCE   8  (residues 1 to 362)
  AUTHORS   Zhao,L.Y., Tsuboi,K., Okamoto,Y., Nagahata,S. and Ueda,N.
  TITLE     Proteolytic activation and glycosylation of
            N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme
            involved in the endocannabinoid metabolism
  JOURNAL   Biochim Biophys Acta 1771 (11), 1397-1405 (2007)
   PUBMED   17980170
REFERENCE   9  (residues 1 to 362)
  AUTHORS   Sun,Y.X., Tsuboi,K., Zhao,L.Y., Okamoto,Y., Lambert,D.M. and
            Ueda,N.
  TITLE     Involvement of N-acylethanolamine-hydrolyzing acid amidase in the
            degradation of anandamide and other N-acylethanolamines in
            macrophages
  JOURNAL   Biochim Biophys Acta 1736 (3), 211-220 (2005)
   PUBMED   16154384
  REMARK    GeneRIF: Results suggest that N-acylethanolamine-hydrolyzing acid
            amidase and fatty acid amide hydrolase cooperatively degrade
            anandamide and other N-acylethanolamines in macrophages.
REFERENCE   10 (residues 1 to 362)
  AUTHORS   Tsuboi,K., Sun,Y.X., Okamoto,Y., Araki,N., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of N-acylethanolamine-hydrolyzing acid
            amidase, a novel member of the choloylglycine hydrolase family with
            structural and functional similarity to acid ceramidase
  JOURNAL   J Biol Chem 280 (12), 11082-11092 (2005)
   PUBMED   15655246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008776.1, AB162194.1, AK133485.1 and AC125542.4.
            
            On Aug 8, 2009 this sequence version replaced NP_080248.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133485.1, AK008776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.35 cM"
     Protein         1..362
                     /product="N-acylethanolamine-hydrolyzing acid amidase
                     isoform 1 precursor"
                     /EC_number="3.5.1.23"
                     /EC_number="3.5.1.60"
                     /note="N-acylethanolamine-hydrolyzing acid amidase;
                     ASAH-like protein; acylsphingosine deacylase NAAA"
                     /calculated_mol_wt=36764
     sig_peptide     1..33
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
                     /calculated_mol_wt=3329
     mat_peptide     34..362
                     /product="N-acylethanolamine-hydrolyzing acid amidase.
                     /id=PRO_0000002319"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D7V9.2)"
                     /calculated_mol_wt=36764
     Region          36..96
                     /region_name="NAAA-beta"
                     /note="beta subunit of N-acylethanolamine-hydrolyzing acid
                     amidase; pfam15508"
                     /db_xref="CDD:464754"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30301806,
                     ECO:0007744|PDB:6DXY; propagated from UniProtKB/Swiss-Prot
                     (Q9D7V9.2)"
     Site            112
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Region          122..351
                     /region_name="Ntn_AC_NAAA"
                     /note="AC_NAAA This conserved domain includes two closely
                     related proteins, acid ceramidase (AC, also known as
                     N-acylsphingosine amidohydrolase), and
                     N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC
                     catalyzes the hydrolysis of ceramide to sphingosine
                     and...; cd01903"
                     /db_xref="CDD:238886"
     Site            147
                     /site_type="other"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000250|UniProtKB:Q02083; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Site            292
                     /site_type="other"
                     /note="Important for enzyme activity.
                     /evidence=ECO:0000250|UniProtKB:Q02083; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     Site            314
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30301806,
                     ECO:0007744|PDB:6DXY; propagated from UniProtKB/Swiss-Prot
                     (Q9D7V9.2)"
     Site            338
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D7V9.2)"
     CDS             1..362
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /coded_by="NM_025972.4:50..1138"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19428.1"
                     /db_xref="GeneID:67111"
                     /db_xref="MGI:MGI:1914361"
ORIGIN      
        1 mgtlatraac hgahlalall lllslsgpwl savvpgtppl fnvsldaape qrwlpmlrhy
       61 dpdflrtava qvigdrvpqw vlgmvgeivs kvesflpqpf tdeirsicds lnlsladgil
      121 vnlayeasaf ctsivaqdsq ghiyhgrnld ypfgkilrkl tanvqfikng qiaftgttfv
      181 gyvglwtgqs phkftisgde rdkgwwwenm iaalslghsp iswlirktls esesfeaavy
      241 tlaktpliad vyyivggtsp kegvvitrdr ggpadiwpld plngewfrve tnydhwkpap
      301 kvddrrtpai kalnatgqah lnletlfqvl slfpvynnyt iyttvmsaae pdkyltmirn
      361 ps
//
LOCUS       NP_001398750             366 aa            linear   ROD 27-AUG-2025
DEFINITION  erythropoietin receptor isoform 3 [Mus musculus].
ACCESSION   NP_001398750 XP_006510061
VERSION     NP_001398750.1
DBSOURCE    REFSEQ: accession NM_001411821.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Abid,D., Murphy,K., Murphy,Z., Rahman,N., Getman,M. and Steiner,L.
  TITLE     The Condensin II complex regulates essential gene expression
            programs during erythropoiesis
  JOURNAL   Development 152 (10) (2025)
   PUBMED   40260585
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Chiu,D.K., Zhang,X., Cheng,B.Y., Liu,Q., Hayashi,K., Yu,B., Lee,R.,
            Zhang,C., An,X., Rajadas,J., Reticker-Flynn,N.E., Rankin,E.B. and
            Engleman,E.G.
  TITLE     Tumor-derived erythropoietin acts as an immunosuppressive switch in
            cancer immunity
  JOURNAL   Science 388 (6745), eadr3026 (2025)
   PUBMED   40273234
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Scherer,T., Metz,M., Beghini,M., Bilban,M., Gensthaler,L.,
            Luca,A.C., Kaplanian,M., Abu Eid,S., Koldyka,O., Hackl,M.T.,
            Durr,S., Rivelles,E., Schonecker,S.S., Poltl,L., Kaya,A., Chami,R.,
            Nusko,L., Tschare,C., Ablaza,K., Hobler,A.L., Klimek,P.,
            Leutner,M., Yamamoto,M., Suzuki,N., Stemmer,K., Zeyda,M.,
            Steinacher,D., Nics,L., Muller,A.M.S., Helbich,T.H., Moriggl,R.,
            Kautzky-Willer,A., Windberger,U., Prager,G. and Furnsinn,C.
  TITLE     A direct effect of the hematocrit on blood glucose: Evidence from
            hypoxia- and erythropoietin-treated mice
  JOURNAL   Sci Adv 11 (16), eadt7366 (2025)
   PUBMED   40238885
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Lyu,J., Gu,Z., Zhang,Y., Vu,H.S., Lechauve,C., Cai,F., Cao,H.,
            Keith,J., Brancaleoni,V., Granata,F., Motta,I., Cappellini,M.D.,
            Huang,L.J., DeBerardinis,R.J., Weiss,M.J., Ni,M. and Xu,J.
  TITLE     A glutamine metabolic switch supports erythropoiesis
  JOURNAL   Science 386 (6723), eadh9215 (2024)
   PUBMED   39541460
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Heberlein,C., Fischer,K.D., Stoffel,M., Nowock,J., Ford,A.,
            Tessmer,U. and Stocking,C.
  TITLE     The gene for erythropoietin receptor is expressed in multipotential
            hematopoietic and embryonal stem cells: evidence for
            differentiation stage-specific regulation
  JOURNAL   Mol Cell Biol 12 (4), 1815-1826 (1992)
   PUBMED   1312671
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Longmore,G.D., Pharr,P. and Lodish,H.F.
  TITLE     Mutation in murine erythropoietin receptor induces
            erythropoietin-independent erythroid proliferation in vitro,
            polycythemia in vivo
  JOURNAL   Leukemia 6 Suppl 3, 130S-134S (1992)
   PUBMED   1318465
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Hino,M., Tojo,A., Misawa,Y., Morii,H., Takaku,F. and Shibuya,M.
  TITLE     Unregulated expression of the erythropoietin receptor gene caused
            by insertion of spleen focus-forming virus long terminal repeat in
            a murine erythroleukemia cell line
  JOURNAL   Mol Cell Biol 11 (11), 5527-5533 (1991)
   PUBMED   1656233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163623.5.
            
            On Sep 6, 2022 this sequence version replaced XP_006510061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.744235.1,
                                           SRR13862101.1401342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.93 cM"
     Protein         1..366
                     /product="erythropoietin receptor isoform 3"
                     /note="EPO-R"
                     /calculated_mol_wt=39423
     Region          18..102
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(91..92,94..95)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..366
                     /gene="Epor"
                     /coded_by="NM_001411821.1:361..1461"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:13857"
                     /db_xref="MGI:MGI:95408"
ORIGIN      
        1 mlldapagll arraeegshv vlrwlpppga pmtthiryev dvsagnragg tqrvevlegr
       61 tecvlsnlrg gtrytfavra rmaepsfsgf wsawsepasl ltasdldpli ltlslilvli
      121 sllltvlall shrrtlqqki wpgipspese feglftthkg nfqlwllqrd gclwwspgss
      181 fpedppahle vlseprwavt qagdpgadde gpllepvgse haqdtylvld kwllprtpcs
      241 enlsgpggsv dpvtmdease tsscpsdlas kprpegtsps sfeytildps sqllcpralp
      301 pelpptpphl kylylvvsds gistdyssgg sqgvhgdssd gpyshpyens lvpdseplhp
      361 gyvacs
//
LOCUS       NP_001409021             466 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1A adrenergic receptor isoform 1 [Mus musculus].
ACCESSION   NP_001409021 XP_017171290
VERSION     NP_001409021.1
DBSOURCE    REFSEQ: accession NM_001422092.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Gural,B., Kirkland,L., Hockett,A., Sandroni,P., Zhang,J.,
            Rosa-Garrido,M., Swift,S.K., Chapski,D.J., Flinn,M.A.,
            O'Meara,C.C., Vondriska,T.M., Patterson,M., Jensen,B.C. and
            Rau,C.D.
  TITLE     Novel insights into post-myocardial infarction cardiac remodeling
            through algorithmic detection of cell-type composition shifts
  JOURNAL   PLoS Genet 21 (7), e1011807 (2025)
   PUBMED   40705823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Docherty,J.R.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Lin,F., Owens,W.A., Chen,S., Stevens,M.E., Kesteven,S.,
            Arthur,J.F., Woodcock,E.A., Feneley,M.P. and Graham,R.M.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (residues 1 to 466)
  AUTHORS   O'Connell,T.D., Rokosh,D.G. and Simpson,P.C.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Xiao,L., Scofield,M.A. and Jeffries,W.B.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (residues 1 to 466)
  AUTHORS   Rockman,H.A., Koch,W.J. and Lefkowitz,R.J.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (residues 1 to 466)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129570.10 and AC154693.2.
            
            On Jun 1, 2023 this sequence version replaced XP_017171290.1.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.15691.1,
                                           SRR1660811.121535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     Protein         1..466
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /note="alpha-1A adrenergic receptor; alpha-1A
                     adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic
                     receptor"
                     /calculated_mol_wt=51613
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Region          27..337
                     /region_name="7tmA_alpha1A_AR"
                     /note="alpha-1 adrenergic receptors subtype A, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15325"
                     /db_xref="CDD:320448"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320448"
     Site            28..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          61..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320448"
     Site            65..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          99..129
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320448"
     Site            100..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            order(102,106..107,110..111,178,185,188..189,192,285,
                     288..289,292,308,312,316)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320448"
     Region          141..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320448"
     Site            144..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320448"
     Site            182..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          265..295
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320448"
     Site            274..297
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          305..330
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320448"
     Site            306..329
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          334..349
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     CDS             1..466
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /coded_by="NM_001422092.1:889..2289"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
ORIGIN      
        1 mvllsenase gsncthppaq vniskaillg vilggliifg vlgnilvils vachrhlhsv
       61 thyyivnlav adllltstvl pfsaifeilg ywafgrvfcn iwaavdvlcc tasimglcii
      121 sidryigvsy plryptivtq rrgvrallcv walslvisig plfgwrqqap edeticqine
      181 epgyvlfsal gsfyvpltii lvmycrvyvv akresrglks glktdksdse qvtlrihrkn
      241 vpaegsgvss aknkthfsvr llkfsrekka aktlgivvgc fvlcwlpffl vmpigsffpn
      301 fkppetvfki vfwlgylnsc inpiiypcss qefkkafqnv lriqclrrrq sskhalgytl
      361 hppsqavegq hrgmvripvg sgetfykisk tdgvrewkff ssmpqgsari tmpkdqsact
      421 tarvrsksfl qvcccvgsst prpeenhqvp tikihtislg engeev
//
LOCUS       NP_056629                349 aa            linear   ROD 27-AUG-2025
DEFINITION  dickkopf-related protein 3 isoform b precursor [Mus musculus].
ACCESSION   NP_056629
VERSION     NP_056629.1
DBSOURCE    REFSEQ: accession NM_015814.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Song,J., Chen,Y., Chen,Y., Qiu,M., Xiang,W., Ke,B. and Fang,X.
  TITLE     DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner
  JOURNAL   Ren Fail 46 (1), 2343817 (2024)
   PUBMED   38682264
  REMARK    GeneRIF: DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner.
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 349)
  AUTHORS   Martin Flores,N., Podpolny,M., McLeod,F., Workman,I., Crawford,K.,
            Ivanov,D., Leonenko,G., Escott-Price,V. and Salinas,P.C.
  TITLE     Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model
  JOURNAL   Elife 12, 89453 (2024)
   PUBMED   38285009
  REMARK    GeneRIF: Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 349)
  AUTHORS   Ang,S.J., Stump,R.J., Lovicu,F.J. and McAvoy,J.W.
  TITLE     Spatial and temporal expression of Wnt and Dickkopf genes during
            murine lens development
  JOURNAL   Gene Expr Patterns 4 (3), 289-295 (2004)
   PUBMED   15053977
REFERENCE   7  (residues 1 to 349)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   8  (residues 1 to 349)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (residues 1 to 349)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (residues 1 to 349)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166834.2 and AK004853.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004853.1, SRR1660811.100602.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.74 cM"
     Protein         1..349
                     /product="dickkopf-related protein 3 isoform b precursor"
                     /note="dickkopf-related protein 3; dickkopf-3; dickkopf
                     homolog 3"
                     /calculated_mol_wt=36225
     sig_peptide     1..22
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN9.1)"
                     /calculated_mol_wt=2181
     mat_peptide     23..349
                     /product="Dickkopf-related protein 3. /id=PRO_0000007223"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN9.1)"
                     /calculated_mol_wt=36225
     Region          41..196
                     /region_name="Dkk3_N_Cys1"
                     /note="N-terminus of Dickkopf-related protein 3; includes
                     the first cysteine-rich (Cys-1) domain; cd23014"
                     /db_xref="CDD:438008"
     Site            96
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN9.1)"
     Site            106
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN9.1)"
     Site            121
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN9.1)"
     Region          147..195
                     /region_name="DKK-type Cys-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN9.1)"
     Region          199..285
                     /region_name="Dkk3_Cys2"
                     /note="second cysteine-rich (Cys-2) domain of
                     Dickkopf-related protein 3; cd23274"
                     /db_xref="CDD:438000"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUN9.1)"
     Region          208..284
                     /region_name="DKK-type Cys-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUN9.1)"
     CDS             1..349
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /coded_by="NM_015814.3:190..1239"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS21752.1"
                     /db_xref="GeneID:50781"
                     /db_xref="MGI:MGI:1354952"
ORIGIN      
        1 mqrlggillc tllaaavpta papsptvtwt paepgpalny pqeeatlnem freveelmed
       61 tqhklrsave emeaeeaaak tssevnlasl ppnyhnetst etrvgnntvh vhqevhkitn
      121 nqsgqvvfse tvitsvgdee gkrsheciid edcgptrycq fssfkytcqp crdqqmlctr
      181 dseccgdqlc awghctqkat kggngticdn qrdcqpglcc afqrgllfpv ctplpvegel
      241 chdptsqlld litwelepeg aldrcpcasg llcqphshsl vymckpafvg shdhseesql
      301 preapdeyed vgfigevrqe ledlerslaq emafegpapv eslggeeei
//
LOCUS       NP_035203                554 aa            linear   ROD 27-AUG-2025
DEFINITION  perforin-1 precursor [Mus musculus].
ACCESSION   NP_035203
VERSION     NP_035203.3
DBSOURCE    REFSEQ: accession NM_011073.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   LaFleur,M.W., Milling,L.E., Prathima,P., Li,V., Lemmen,A.M.,
            Streeter,I.S.L., Heisig,P.K.S., Derosia,N.M., Riffo,E., Xu,H.,
            Nguyen,T.H., Kolengaden,A., Markson,S.C., Doench,J.G. and
            Sharpe,A.H.
  TITLE     A STUB1-CHIC2 complex inhibits CD8+ T cells to restrain tumor
            immunity
  JOURNAL   Nat Immunol (2025) In press
   PUBMED   40796662
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Krstanovic,F., Mihalic,A., Rashidi,A.S., Sitnik,K.M., Ruzsics,Z.,
            Cicin-Sain,L., Verjans,G.M.G.M., Jonjic,S. and Brizic,I.
  TITLE     Neuron-restricted cytomegalovirus latency in the central nervous
            system regulated by CD4+ T-cells and IFN-gamma
  JOURNAL   J Neuroinflammation 22 (1), 95 (2025)
   PUBMED   40158177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Lee,S., Ricci,B., Tran,J., Eul,E., Ye,J., Ren,Q., Clever,D.,
            Wang,J., Wong,P., Haas,M.S., Stewart,S.A., Ma,C.X., Fehniger,T.A.
            and Faccio,R.
  TITLE     Stroma-derived Dickkopf-1 contributes to the suppression of NK cell
            cytotoxicity in breast cancer
  JOURNAL   Nat Commun 16 (1), 1183 (2025)
   PUBMED   39885132
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Diehl,C., Soberon,V., Baygun,S., Chu,Y., Mandelbaum,J., Kraus,L.,
            Engleitner,T., Rudelius,M., Fangazio,M., Daniel,C., Bortoluzzi,S.,
            Helmrath,S., Singroul,P., Golling,V., Osorio Barrios,F., Seyhan,G.,
            Osswald,L., Kober-Hasslacher,M., Zeng,T., Ollinger,R., Afzali,A.M.,
            Korn,T., Honarpisheh,M., Lech,M., Ul Ain,Q., Pircher,J.,
            Imsirovic,V., Jelencic,V., Wensveen,F.M., Passerini,V., Barthel,S.,
            Bhagat,G., Dominguez-Sola,D., Saur,D., Steiger,K., Rad,R.,
            Pasqualucci,L., Weigert,O. and Schmidt-Supprian,M.
  TITLE     Hyperreactive B cells instruct their elimination by T cells to curb
            autoinflammation and lymphomagenesis
  JOURNAL   Immunity 58 (1), 124-142 (2025)
   PUBMED   39729992
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Mann,J., Runge,S., Schell,C., Grawe,K., Thoulass,G., Lao,J.,
            Ammann,S., Grun,S., Konig,C., Berger,S.A., Hild,B., Aichele,P.,
            Rosshart,S.P. and Ehl,S.
  TITLE     The Microbiome Modifies Manifestations of Hemophagocytic
            Lymphohistiocytosis in Perforin-Deficient Mice
  JOURNAL   Eur J Immunol 55 (1), e202451061 (2025)
   PUBMED   39548906
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Lichtenheld,M.G. and Podack,E.R.
  TITLE     Structure and function of the murine perforin promoter and upstream
            region. Reciprocal gene activation or silencing in perforin
            positive and negative cells
  JOURNAL   J Immunol 149 (8), 2619-2626 (1992)
   PUBMED   1401900
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Fink,T.M., Zimmer,M., Weitz,S., Tschopp,J., Jenne,D.E. and
            Lichter,P.
  TITLE     Human perforin (PRF1) maps to 10q22, a region that is syntenic with
            mouse chromosome 10
  JOURNAL   Genomics 13 (4), 1300-1302 (1992)
   PUBMED   1505959
REFERENCE   8  (residues 1 to 554)
  AUTHORS   Kawasaki,A., Shinkai,Y., Yagita,H. and Okumura,K.
  TITLE     Expression of perforin in murine natural killer cells and cytotoxic
            T lymphocytes in vivo
  JOURNAL   Eur J Immunol 22 (5), 1215-1219 (1992)
   PUBMED   1577064
REFERENCE   9  (residues 1 to 554)
  AUTHORS   Trapani,J.A. and Dupont,B.
  TITLE     Novel putative promoter/enhancer sequences are shared by the mouse
            and human perforin (Pfp) genes
  JOURNAL   Tissue Antigens 36 (5), 228-234 (1990)
   PUBMED   2095003
REFERENCE   10 (residues 1 to 554)
  AUTHORS   Kozak,C.A., Peyser,M., Krall,M., Mariano,T.M., Kumar,C.S.,
            Pestka,S. and Mock,B.A.
  TITLE     Molecular genetic markers spanning mouse chromosome 10
  JOURNAL   Genomics 8 (3), 519-524 (1990)
   PUBMED   1981053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132300.1.
            
            On Mar 28, 2009 this sequence version replaced NP_035203.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132300.1, M23182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.18 cM"
     Protein         1..554
                     /product="perforin-1 precursor"
                     /note="perforin-1; P1; cytolysin; lymphocyte pore-forming
                     protein; pore forming protein"
                     /calculated_mol_wt=59914
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2186
     mat_peptide     21..554
                     /product="Perforin-1. /id=PRO_0000023610"
                     /note="propagated from UniProtKB/Swiss-Prot (P10820.2)"
                     /calculated_mol_wt=59914
     Site            128..148
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P10820.2)"
     Region          166..368
                     /region_name="MACPF"
                     /note="membrane-attack complex / perforin; smart00457"
                     /db_xref="CDD:214671"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21037563,
                     ECO:0000269|PubMed:35148176, ECO:0007744|PDB:3NSJ,
                     ECO:0007744|PDB:7PAG; propagated from UniProtKB/Swiss-Prot
                     (P10820.2)"
     Site            213
                     /site_type="other"
                     /note="Important for oligomerization.
                     /evidence=ECO:0000269|PubMed:19446473; propagated from
                     UniProtKB/Swiss-Prot (P10820.2)"
     Site            256..278
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P10820.2)"
     Site            343
                     /site_type="other"
                     /note="Important for oligomerization.
                     /evidence=ECO:0000269|PubMed:19446473; propagated from
                     UniProtKB/Swiss-Prot (P10820.2)"
     Site            375
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10820.2)"
     Region          387..513
                     /region_name="C2_Perforin"
                     /note="C2 domain of Perforin; cd04032"
                     /db_xref="CDD:175998"
     Site            order(429,435,483,485,491)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175998"
     Site            548
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10820.2)"
     CDS             1..554
                     /gene="Prf1"
                     /gene_synonym="Pfn; Pfp; Prf-1"
                     /coded_by="NM_011073.3:56..1720"
                     /db_xref="CCDS:CCDS23875.1"
                     /db_xref="GeneID:18646"
                     /db_xref="MGI:MGI:97551"
ORIGIN      
        1 matclfllgl flllprpvpa pcytatrsec kqkhkfvpgv wmagegmdvt tlrrsgsfpv
       61 ntqrflrpdr tctlcknslm rdatqrlpva ithwrphssh cqrnvaaakv hstegvarea
      121 aaninndwrv gldvnprpea nmrasvagsh skvanfaaek tyqdqynfns dtvecrmysf
      181 rlvqkpplhl dfkkalralp rnfnssteha yhrlissygt hfitavdlgg risvltalrt
      241 cqltlnglta devgdclnve aqvsigaqas vsseykacee kkkqhkmats fhqtyrerhv
      301 evlggpldst hdllfgnqat peqfstwtas lpsnpglvdy sleplhtlle eqnpkrealr
      361 qaishyimsr arwqncsrpc rsgqhksshd scqcecqdsk vtnqdccprq rglahlvvsn
      421 fraehlwgdy ttatdaylkv ffggqefrtg vvwnnnnprw tdkmdfenvl lstggplrvq
      481 vwdadygwdd dllgscdrsp hsgfhevtce lnhgrvkfsy hakclphltg gtcleyapqg
      541 llgdppgnrs gavw
//
LOCUS       NP_001371260             147 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin regulatory light chain 2, ventricular/cardiac muscle isoform
            isoform 2 [Mus musculus].
ACCESSION   NP_001371260
VERSION     NP_001371260.1
DBSOURCE    REFSEQ: accession NM_001384331.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Xu,F., Huang,H., Peng,K., Jian,C., Wu,H., Jing,Z., Qiu,S., Chen,Y.,
            Liu,K., Fu,L., Wang,Y., Yang,J., Duan,X., Wang,C., Cheng,H. and
            Wang,X.
  TITLE     ROMO1 overexpression protects the mitochondrial cysteinome from
            oxidations in aging
  JOURNAL   Nat Commun 16 (1), 5133 (2025)
   PUBMED   40461459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Sheikh,F., Lyon,R.C. and Chen,J.
  TITLE     Functions of myosin light chain-2 (MYL2) in cardiac muscle and
            disease
  JOURNAL   Gene 569 (1), 14-20 (2015)
   PUBMED   26074085
  REMARK    Review article
            Erratum:[Gene. 2015 Oct 15;571(1):151]
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Lee,K.F., Simon,H., Chen,H., Bates,B., Hung,M.C. and Hauser,C.
  TITLE     Requirement for neuregulin receptor erbB2 in neural and cardiac
            development
  JOURNAL   Nature 378 (6555), 394-398 (1995)
   PUBMED   7477377
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Lee,K.J., Ross,R.S., Rockman,H.A., Harris,A.N., O'Brien,T.X., van
            Bilsen,M., Shubeita,H.E., Kandolf,R., Brem,G., Price,J. et al.
  TITLE     Myosin light chain-2 luciferase transgenic mice reveal distinct
            regulatory programs for cardiac and skeletal muscle-specific
            expression of a single contractile protein gene
  JOURNAL   J Biol Chem 267 (22), 15875-15885 (1992)
   PUBMED   1379240
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Hastings,K.E. and Emerson,C.P. Jr.
  TITLE     cDNA clone analysis of six co-regulated mRNAs encoding skeletal
            muscle contractile proteins
  JOURNAL   Proc Natl Acad Sci U S A 79 (5), 1553-1557 (1982)
   PUBMED   6951196
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Czosnek,H., Nudel,U., Shani,M., Barker,P.E., Pravtcheva,D.D.,
            Ruddle,F.H. and Yaffe,D.
  TITLE     The genes coding for the muscle contractile proteins, myosin heavy
            chain, myosin light chain 2, and skeletal muscle actin are located
            on three different mouse chromosomes
  JOURNAL   EMBO J 1 (11), 1299-1305 (1982)
   PUBMED   6897916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140353.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.59265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     Protein         1..147
                     /product="myosin regulatory light chain 2,
                     ventricular/cardiac muscle isoform isoform 2"
                     /note="myosin light chain 2v; myosin light chain,
                     phosphorylatable, cardiac ventricles"
                     /calculated_mol_wt=16716
     Region          1..141
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..147
                     /gene="Myl2"
                     /gene_synonym="Gm32672; MLC-2; MLC-2s/v; MLC-2v; Mlc2v;
                     Mylpc"
                     /coded_by="NM_001384331.1:1028..1471"
                     /note="isoform 2 is encoded by transcript variant 7"
                     /db_xref="GeneID:17906"
                     /db_xref="MGI:MGI:97272"
ORIGIN      
        1 mfeqtqiqef keaftimdqn rdgfidkndl rdtfaalgrv nvkneeidem ikeapgpinf
       61 tvfltmfgek lkgadpeeti lnafkvfdpe gkgslkadyv remlttqaer fskeeidqmf
      121 aafppdvtgn ldyknlvhii thgeekd
//
LOCUS       NP_033415                772 aa            linear   ROD 27-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform 2 [Mus musculus].
ACCESSION   NP_033415 XP_001003585
VERSION     NP_033415.2
DBSOURCE    REFSEQ: accession NM_009389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 772)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 772)
  AUTHORS   Kalita,B., Sahu,S., Bharadwaj,A., Panneerselvam,L.,
            Martinez-Cebrian,G., Agarwal,M. and Mathew,S.J.
  TITLE     The Wnt-pathway corepressor TLE3 interacts with the histone
            methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma
  JOURNAL   Oncogene 43 (7), 524-538 (2024)
   PUBMED   38177411
  REMARK    GeneRIF: The Wnt-pathway corepressor TLE3 interacts with the
            histone methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma.
REFERENCE   4  (residues 1 to 772)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   5  (residues 1 to 772)
  AUTHORS   Kumar,P., Zehra,A., Saini,M. and Mathew,S.J.
  TITLE     Zeb1 and Tle3 are trans-factors that differentially regulate the
            expression of myosin heavy chain-embryonic and skeletal muscle
            differentiation
  JOURNAL   FASEB J 37 (8), e23074 (2023)
   PUBMED   37392376
  REMARK    GeneRIF: Zeb1 and Tle3 are trans-factors that differentially
            regulate the expression of myosin heavy chain-embryonic and
            skeletal muscle differentiation.
REFERENCE   6  (residues 1 to 772)
  AUTHORS   Leon,C. and Lobe,C.G.
  TITLE     Grg3, a murine Groucho-related gene, is expressed in the developing
            nervous system and in mesenchyme-induced epithelial structures
  JOURNAL   Dev Dyn 208 (1), 11-24 (1997)
   PUBMED   8989517
REFERENCE   7  (residues 1 to 772)
  AUTHORS   Koop,K.E., MacDonald,L.M. and Lobe,C.G.
  TITLE     Transcripts of Grg4, a murine groucho-related gene, are detected in
            adjacent tissues to other murine neurogenic gene homologues during
            embryonic development
  JOURNAL   Mech Dev 59 (1), 73-87 (1996)
   PUBMED   8892234
REFERENCE   8  (residues 1 to 772)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   9  (residues 1 to 772)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
REFERENCE   10 (residues 1 to 772)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611599.1, BQ770333.1, AK122524.1, AK031322.1, AC126672.3 and
            BX630781.1.
            
            On Apr 13, 2007 this sequence version replaced NP_033415.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.27 cM"
     Protein         1..772
                     /product="transducin-like enhancer protein 3 isoform 2"
                     /note="transducin-like enhancer protein 3; grg-3;
                     transducin-like enhancer of split 3, homolog of Drosophila
                     E(spl)"
                     /calculated_mol_wt=83316
     Region          1..131
                     /region_name="Q domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          18..133
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          130..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          132..199
                     /region_name="GP domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          184..347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          200..268
                     /region_name="CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Site            203
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            211
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            217
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          225..228
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Site            232
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            245
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          <251..472
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Site            259
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            263
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            267
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          269..452
                     /region_name="SP domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Site            275
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            312
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            413
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          484..522
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          <485..770
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          489..528
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          530..569
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          536..574
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          574..613
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          579..615
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          616..655
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          622..657
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          657..696
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          662..695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          698..737
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          703..737
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          739..771
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          744..768
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..772
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /coded_by="NM_009389.2:1073..3391"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS52825.1"
                     /db_xref="GeneID:21887"
                     /db_xref="MGI:MGI:104634"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg algsqahlav
      181 kdeknhheld hreresstnn svspseslra sekhrgsady smeakkrkae ekdslsryds
      241 dgdksddlvv dvsnedpatp rvspahsppe ngldkarglk kdaptspasv asssstpssk
      301 tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi gimasalrtp
      361 itltssypap fammshhemn gsltspsaya glhnipsqms aaaaaaaaay grspmvsfga
      421 vgfdphppmr atglpsslas ipggkpaysf hvsadgqmqp vpfphdalag pgiprharqi
      481 ntlshgevvc avtisnptrh vytggkgcvk iwdisqpgsk spisqldcln rdnyirsckl
      541 lpdgrtlivg geastltiwd lasptprika eltssapacy alaispdakv cfsccsdgni
      601 avwdlhnqtl vrqfqghtdg ascidishdg tklwtggldn tvrswdlreg rqlqqhdfts
      661 qifslgycpt gewlavgmes snvevlhhtk pdkyqlhlhe scvlslkfay cgkwfvstgk
      721 dnllnawrtp ygasifqske sssvlscdis addkyivtgs gdkkatvyev iy
//
LOCUS       NP_001405742             150 aa            linear   ROD 27-AUG-2025
DEFINITION  COMM domain-containing protein 10 isoform 9 [Mus musculus].
ACCESSION   NP_001405742 XP_006526291
VERSION     NP_001405742.1
DBSOURCE    REFSEQ: accession NM_001418813.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 150)
  AUTHORS   Bi,H., Ren,K., Wang,P., Li,E., Han,X., Wang,W., Yang,J.,
            Aydemir,I., Tao,K., Ma,R., Godley,L.A., Liu,Y., Shukla,V.,
            Bartom,E.T., Tang,Y., Blanc,L., Sukhanova,M. and Ji,P.
  TITLE     DDX41 resolves G-quadruplexes to maintain erythroid genome
            integrity and prevent cGAS-mediated cell death
  JOURNAL   Nat Commun 16 (1), 7195 (2025)
   PUBMED   40764304
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 150)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 150)
  AUTHORS   Zhang,N., Fei,X., Wen,J., Zhang,L., Liu,X., Sun,B., Wang,K.,
            Wang,X. and Ji,H.
  TITLE     VGLL4 deficiency in T cells promotes tumor initiation and
            progression
  JOURNAL   Cancer Lett 622, 217682 (2025)
   PUBMED   40216153
REFERENCE   4  (residues 1 to 150)
  AUTHORS   Morrison,T.A., Vigee,J., Tovar,K.A., Talley,T.A., Mujal,A.M.,
            Kono,M., Philips,R., Nagashima,H., Brooks,S.R., Dada,H., Rozich,I.,
            Hudspeth,K., Lau,C.M., Yao,C., Sciume,G., Sun,H.W.,
            Bonifacino,J.S., Kanno,Y., Dustin,M.L., Randazzo,D., Proia,R.L.,
            Sun,J.C., Shih,H.Y. and O'Shea,J.J.
  TITLE     Selective requirement of glycosphingolipid synthesis for natural
            killer and cytotoxic T cells
  JOURNAL   Cell 188 (13), 3497-3512 (2025)
   PUBMED   40306279
REFERENCE   5  (residues 1 to 150)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 150)
  AUTHORS   Delogu,A., Schebesta,A., Sun,Q., Aschenbrenner,K., Perlot,T. and
            Busslinger,M.
  TITLE     Gene repression by Pax5 in B cells is essential for blood cell
            homeostasis and is reversed in plasma cells
  JOURNAL   Immunity 24 (3), 269-281 (2006)
   PUBMED   16546096
REFERENCE   7  (residues 1 to 150)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   8  (residues 1 to 150)
  AUTHORS   de Boer,J., Williams,A., Skavdis,G., Harker,N., Coles,M.,
            Tolaini,M., Norton,T., Williams,K., Roderick,K., Potocnik,A.J. and
            Kioussis,D.
  TITLE     Transgenic mice with hematopoietic and lymphoid specific expression
            of Cre
  JOURNAL   Eur J Immunol 33 (2), 314-325 (2003)
   PUBMED   12548562
REFERENCE   9  (residues 1 to 150)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 150)
  AUTHORS   Ogilvy,S., Metcalf,D., Gibson,L., Bath,M.L., Harris,A.W. and
            Adams,J.M.
  TITLE     Promoter elements of vav drive transgene expression in vivo
            throughout the hematopoietic compartment
  JOURNAL   Blood 94 (6), 1855-1863 (1999)
   PUBMED   10477714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132100.3 and AC117239.4.
            
            On Mar 23, 2023 this sequence version replaced XP_006526291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.450984.1,
                                           SRR9219381.58844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.9 cM"
     Protein         1..150
                     /product="COMM domain-containing protein 10 isoform 9"
                     /note="COMM domain-containing protein 10; mDRWMS2;
                     down-regulated in W/WV mouse stomach 2; Tg(Vav1-cre)1Kio;
                     Tg(Vav1-cre)A2Kio"
                     /calculated_mol_wt=16739
     Region          15..149
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..150
                     /gene="Commd10"
                     /gene_synonym="2310003A05Rik; DRWMS2; Tg(Vav1-icre)A2Kio;
                     Vav-cre; Vav-iCre; Vav1-Cre; VavCre"
                     /coded_by="NM_001418813.1:39..491"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /db_xref="GeneID:69456"
                     /db_xref="MGI:MGI:1916706"
ORIGIN      
        1 maasaalilp espsmkkavp linaidtgrf prllsrilqk lhlkaessfs eeeeeklqaa
       61 fslekqelhl vletisfvle qletvgwqln lqmahsaqak lqspqavlql gvskedaknv
      121 ekvlvefnhk elfdfynkle tiqaqldslt
//
LOCUS       NP_001415383             168 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA damage-inducible transcript 3 protein [Mus musculus].
ACCESSION   NP_001415383 XP_006513260
VERSION     NP_001415383.1
DBSOURCE    REFSEQ: accession NM_001428454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 168)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 168)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 168)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 168)
  AUTHORS   Zhu,S., Huo,S., He,W., Huang,C., Zhang,J., Jiang,X., Qian,Y.,
            Chen,C., Dai,Z.M., Yang,X., Qiu,M., Li,T. and Zhu,X.J.
  TITLE     Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the
            mouse craniofacial development
  JOURNAL   iScience 28 (3), 111972 (2025)
   PUBMED   40071146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 168)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 168)
  AUTHORS   Jousse,C., Bruhat,A., Carraro,V., Urano,F., Ferrara,M., Ron,D. and
            Fafournoux,P.
  TITLE     Inhibition of CHOP translation by a peptide encoded by an open
            reading frame localized in the chop 5'UTR
  JOURNAL   Nucleic Acids Res 29 (21), 4341-4351 (2001)
   PUBMED   11691921
REFERENCE   7  (residues 1 to 168)
  AUTHORS   Zinszner,H., Kuroda,M., Wang,X., Batchvarova,N., Lightfoot,R.T.,
            Remotti,H., Stevens,J.L. and Ron,D.
  TITLE     CHOP is implicated in programmed cell death in response to impaired
            function of the endoplasmic reticulum
  JOURNAL   Genes Dev 12 (7), 982-995 (1998)
   PUBMED   9531536
REFERENCE   8  (residues 1 to 168)
  AUTHORS   Fleming,J.V., Fontanier,N., Harries,D.N. and Rees,W.D.
  TITLE     The growth arrest genes gas5, gas6, and CHOP-10 (gadd153) are
            expressed in the mouse preimplantation embryo
  JOURNAL   Mol Reprod Dev 48 (3), 310-316 (1997)
   PUBMED   9322241
REFERENCE   9  (residues 1 to 168)
  AUTHORS   Ubeda,M., Wang,X.Z., Zinszner,H., Wu,I., Habener,J.F. and Ron,D.
  TITLE     Stress-induced binding of the transcriptional factor CHOP to a
            novel DNA control element
  JOURNAL   Mol Cell Biol 16 (4), 1479-1489 (1996)
   PUBMED   8657121
REFERENCE   10 (residues 1 to 168)
  AUTHORS   Ron,D. and Habener,J.F.
  TITLE     CHOP, a novel developmentally regulated nuclear protein that
            dimerizes with transcription factors C/EBP and LAP and functions as
            a dominant-negative inhibitor of gene transcription
  JOURNAL   Genes Dev 6 (3), 439-453 (1992)
   PUBMED   1547942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144852.3.
            
            On Mar 12, 2024 this sequence version replaced XP_006513260.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.3508443.1,
                                           SRR17253014.2524485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     Protein         1..168
                     /product="DNA damage-inducible transcript 3 protein"
                     /note="C/EBP zeta; CCAAT/enhancer-binding protein
                     homologous protein; DDIT-3; growth arrest and
                     DNA-damage-inducible protein GADD153; c/EBP-homologous
                     protein 10; C/EBP homoologous protein 10; alternative
                     DDIT3 proteins"
                     /calculated_mol_wt=19058
     Region          10..26
                     /region_name="N-terminal. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Region          10..18
                     /region_name="Interaction with TRIB3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            31
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:12876286; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Region          34..139
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:8650547; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK14.
                     /evidence=ECO:0000269|PubMed:8650547; propagated from
                     UniProtKB/Swiss-Prot (P35639.1)"
     Region          100..160
                     /region_name="BRLZ"
                     /note="basic region leucin zipper; smart00338"
                     /db_xref="CDD:197664"
     Region          100..129
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     Region          102..152
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269834"
     Site            order(104..105,107..109,111..116,118..120)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269834"
     Site            order(119,122..123,126..127,129..130,133..134,136..137,
                     140..141,143..144,147..148,150..151)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269834"
     Region          133..147
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P35639.1)"
     CDS             1..168
                     /gene="Ddit3"
                     /gene_synonym="AltDDIT3; chop; CHOP-10; CHOP10; gadd153"
                     /coded_by="NM_001428454.1:274..780"
                     /db_xref="GeneID:13198"
                     /db_xref="MGI:MGI:109247"
ORIGIN      
        1 maaeslpftl etvsswelea wyedlqevls sdeiggtyis spgneeeesk tfttldpasl
       61 awlteepgpt evtrtsqspr spdssqssma qeeeeeeqgr trkrkqsgqc parpgkqrmk
      121 ekeqenerkv aqlaeenerl kqeierltre vettrralid rmvslhqa
//
LOCUS       NP_001334509             389 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 7 [Mus musculus].
ACCESSION   NP_001334509
VERSION     NP_001334509.1
DBSOURCE    REFSEQ: accession NM_001347580.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 389)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 389)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 389)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 389)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 389)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 389)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 389)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 389)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 389)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 389)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            Transcript Variant: This variant (17) differs in the 5' UTR, and
            uses an alternate splice site that results in a frameshift in the
            3' coding region, compared to variant 3. The encoded isoform (7)
            has a distinct C-terminus and is shorter than isoform 3. Both
            variants 16 and 17 encode isoform 7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.172375.1,
                                           SRR7345562.692882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..389
                     /product="myocyte-specific enhancer factor 2C isoform 7"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=41808
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            4
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:18086704; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:8663403; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          91..118
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            116
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            119
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            234
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            239
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            252
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            264
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          271..278
                     /region_name="Beta domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            293
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     CDS             1..389
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347580.2:404..1573"
                     /note="isoform 7 is encoded by transcript variant 17"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv sedvdlllnq rinnsqsaqs latpvvsvat
      301 ptlpgqgmgg ypsaisttyg teyslssadl sslsgfntas alhlgsvtgw qqqhlhnmpp
      361 salsqlgpyh hpfeiptthh aprggevsc
//
LOCUS       NP_996988                265 aa            linear   ROD 27-AUG-2025
DEFINITION  histocompatibility 2, class II antigen A, beta 1 precursor [Mus
            musculus].
ACCESSION   NP_996988 NP_034509
VERSION     NP_996988.2
DBSOURCE    REFSEQ: accession NM_207105.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 265)
  AUTHORS   Kageyama,M., Ohashi,K. and Ota,T.
  TITLE     Functional significance of commonly regulated genes in mechanically
            and chemically induced retinal ganglion cell death in rat eyes
  JOURNAL   Sci Rep 15 (1), 23681 (2025)
   PUBMED   40604065
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 265)
  AUTHORS   Chen,R., Powell,J.S., Shufesky,W.J., Bardhi,E., Sullivan,M.L.G.,
            Tkacheva,O.A., Camirand,G., Goncalves,Z., Stolz,D.B., Chalasani,G.,
            Catz,S.D., Watkins,S.C., Larregina,A.T. and Morelli,A.E.
  TITLE     Transplants foster B cell alloimmunity by relaying extracellular
            vesicles to follicular dendritic cells
  JOURNAL   Cell Rep 44 (6), 115832 (2025)
   PUBMED   40516053
REFERENCE   3  (residues 1 to 265)
  AUTHORS   Zhao,Z., Hu,B., Deng,Y., Soeung,M., Yao,J., Bei,L., Zhang,Y.,
            Gong,P., Huang,L.A., Jiang,Z., Gao,J., Peng,S., Nguyen,T.K.,
            Karki,M., Lim,B., Yee,C., Burks,J.K., Zhang,Q., Ma,L., Gao,J.,
            Tannir,N.M., Han,L., Yu,D., Wang,L., Curran,M.A., Gubbiotti,M.A.,
            Genovese,G., Gan,B., Li,W., Msaouel,P., Yang,L. and Lin,C.
  TITLE     Sickle cell disease induces chromatin introversion and ferroptosis
            in CD8+ T cells to suppress anti-tumor immunity
  JOURNAL   Immunity 58 (6), 1484-1501 (2025)
   PUBMED   40359940
REFERENCE   4  (residues 1 to 265)
  AUTHORS   Hu,X., White,K., Olroyd,A.G., Friera,A., Wang,C., Caruso,C.B.,
            Connolly,A.J., Deuse,T. and Schrepfer,S.
  TITLE     Hypoimmune CD19 CAR T cells treat allogeneic mice with features of
            spontaneous systemic lupus erythematosus
  JOURNAL   iScience 28 (7), 112806 (2025)
   PUBMED   40606751
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 265)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 265)
  AUTHORS   Miki,N., Hatano,M., Wakita,K., Imoto,S., Nishikawa,S., Nishikawa,S.
            and Tokuhisa,T.
  TITLE     Role of I-A molecules in early stages of B cell maturation
  JOURNAL   J Immunol 149 (3), 801-807 (1992)
   PUBMED   1378867
REFERENCE   7  (residues 1 to 265)
  AUTHORS   Infante,A.J., Levcovitz,H., Gordon,V., Wall,K.A., Thompson,P.A. and
            Krolick,K.A.
  TITLE     Preferential use of a T cell receptor V beta gene by acetylcholine
            receptor reactive T cells from myasthenia gravis-susceptible mice
  JOURNAL   J Immunol 148 (11), 3385-3390 (1992)
   PUBMED   1375242
REFERENCE   8  (residues 1 to 265)
  AUTHORS   Sertic,J., Zaleska-Rutczynska,Z., Vincek,V., Nadeau,J.H.,
            Figueroa,F. and Klein,J.
  TITLE     Mapping of six DNA markers on mouse chromosome 17
  JOURNAL   Mamm Genome 2 (2), 138-142 (1992)
   PUBMED   1347473
REFERENCE   9  (residues 1 to 265)
  AUTHORS   McKenzie,I.F., Morgan,G.M., Sandrin,M.S., Michaelides,M.M.,
            Melvold,R.W. and Kohn,H.I.
  TITLE     B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse
  JOURNAL   J Exp Med 150 (6), 1323-1338 (1979)
   PUBMED   159937
REFERENCE   10 (residues 1 to 265)
  AUTHORS   Shreffler,D.C. and David,C.S.
  TITLE     The H-2 major histocompatibility complex and the I immune response
            region: genetic variation, function, and organization
  JOURNAL   Adv Immunol 20, 125-195 (1975)
   PUBMED   47219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205244.1, AK077436.1, CK330363.1 and BB056841.1.
            
            On Apr 22, 2010 this sequence version replaced NP_996988.1.
            
            Sequence Note: This record matches the C57BL/6J reference assembly
            sequence and represents the b haplotype of this gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171281.1, AK077436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     Protein         1..265
                     /product="histocompatibility 2, class II antigen A, beta 1
                     precursor"
                     /note="H-2 class II histocompatibility antigen, A beta
                     chain; response to metastatic cancers 1; MHC class II
                     H2-IA-beta-psi; major histocompatibility complex class II
                     beta chain; histocompatibility 2, class II antigen A,
                     beta, promoter 1"
                     /calculated_mol_wt=27449
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2697
     mat_peptide     28..265
                     /product="H-2 class II histocompatibility antigen, A beta
                     chain. /id=PRO_0000018993"
                     /note="propagated from UniProtKB/Swiss-Prot (P14483.1)"
                     /calculated_mol_wt=27449
     Region          28..122
                     /region_name="Beta-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P14483.1)"
     Region          40..111
                     /region_name="MHC_II_beta"
                     /note="Class II histocompatibility antigen, beta domain;
                     smart00921"
                     /db_xref="CDD:197989"
     Site            46
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P14483.1)"
     Region          123..218
                     /region_name="IgC1_MHC_II_beta_HLA-DQ_I-A"
                     /note="Class II major histocompatibility complex (MHC)
                     beta chain immunoglobulin domain of histocompatibility
                     antigen (HLA) DQ and I-A; member of the C1-set of Ig
                     superfamily (IgSF) domains; cd21001"
                     /db_xref="CDD:409592"
     Region          123..216
                     /region_name="Beta-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P14483.1)"
     Region          124..132
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409592"
     Site            order(130,148..149,151,177..184)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409592"
     Region          142..151
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409592"
     Site            order(151,179..181,183)
                     /site_type="other"
                     /note="MHC binding domain interface [polypeptide binding]"
                     /db_xref="CDD:409592"
     Region          155..161
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409592"
     Region          163..166
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409592"
     Region          170..178
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409592"
     Region          181..191
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409592"
     Region          198..205
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409592"
     Region          212..216
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409592"
     Region          217..226
                     /region_name="Connecting peptide"
                     /note="propagated from UniProtKB/Swiss-Prot (P14483.1)"
     Site            227..247
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P14483.1)"
     CDS             1..265
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /coded_by="NM_207105.3:86..883"
                     /db_xref="CCDS:CCDS37583.1"
                     /db_xref="GeneID:14961"
                     /db_xref="MGI:MGI:103070"
ORIGIN      
        1 malqipslll saavvvlmvl sspgteggds erhfvyqfmg ecyftngtqr iryvtryiyn
       61 reeyvrydsd vgehravtel grpdaeywns qpeilertra eldtvcrhny egpethtslr
      121 rleqpnvvis lsrtealnhh ntlvcsvtdf ypakikvrwf rngqeetvgv sstqlirngd
      181 wtfqvlvmle mtprrgevyt chvehpslks pitvewraqs esawskmlsg iggcvlgvif
      241 lglglfirhr sqkgprgppp agllq
//
LOCUS       NP_941004                676 aa            linear   ROD 27-AUG-2025
DEFINITION  protein CASP isoform b [Mus musculus].
ACCESSION   NP_941004
VERSION     NP_941004.2
DBSOURCE    REFSEQ: accession NM_198602.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 676)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 676)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 676)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 676)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 676)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 676)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 676)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 676)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 676)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 676)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Jul 28, 2006 this sequence version replaced NP_941004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098096.1, BC054370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..676
                     /product="protein CASP isoform b"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=77031
     Region          <107..375
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          421..641
                     /region_name="CASP_C"
                     /note="CASP C terminal; pfam08172"
                     /db_xref="CDD:462392"
     Site            584
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13948; propagated from
                     UniProtKB/Swiss-Prot (P70403.2)"
     Site            618..638
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70403.2)"
     CDS             1..676
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_198602.4:24..2054"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57391.1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 maanvgsmfq ywkrfdlqql qreldatatv lanrqdeseq srkrlieqsr efkkntpedl
       61 rkqvapllks fqgeidalsk rskeaeaafl tvykrlidvp dpvpaldvgq qleikvqrlh
      121 dietenqklr etleeynkef aevknqevti kalkekirey eqtlksqaet ialekeqklq
      181 ndfaekerkl qetqmsttsk leeaehklqt lqtalektrt elfdlktkyd eettakadei
      241 emimtdlera nqraevaqre aetlreqlss anhslqlasq iqkapdvaie vltrssleve
      301 laakereiaq lvedvqrlqa sltklrensa sqisqleqql naknstlkql eeklkgqady
      361 eevkkelntl ksmefapseg agtqdstkpl evllleknrs lqsenatlri snsdlsgrca
      421 elqihlteat akaveqkeli arleqdlsti qsiqrpdaeg aseqglekip epikeatalf
      481 ygpsmsssgt lpegqvdsll siissqrerf rtrnqeleae srmaqhtiqa lqseldslra
      541 dniklfekik flqsypgrgi gsddtelrys sqyeerldpf ssfskrerqr kylglspwdk
      601 atlgmgrlil snkmartisf fytlflhclv flvlyklaws esverdcaat cakkfadhlh
      661 kfhesdngaa agdlwq
//
LOCUS       NP_035928                322 aa            linear   ROD 27-AUG-2025
DEFINITION  chemokine XC receptor 1 [Mus musculus].
ACCESSION   NP_035928
VERSION     NP_035928.3
DBSOURCE    REFSEQ: accession NM_011798.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 322)
  AUTHORS   Heras-Murillo,I., Mananes,D., Munne,P., Nunez,V., Herrera,J.,
            Catala-Montoro,M., Alvarez,M., Del Pozo,M.A., Melero,I.,
            Wculek,S.K. and Sancho,D.
  TITLE     Immunotherapy with conventional type-1 dendritic cells induces
            immune memory and limits tumor relapse
  JOURNAL   Nat Commun 16 (1), 3369 (2025)
   PUBMED   40204706
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 322)
  AUTHORS   Mauvais,F.X., Hamel,Y., Silvin,A., Mulder,K., Hildner,K., Akyol,R.,
            Dalod,M., Koumantou,D., Saveanu,L., Garfa,M., Cagnard,N.,
            Bertocci,B., Ginhoux,F. and van Endert,P.
  TITLE     Metallophilic marginal zone macrophages cross-prime CD8+ T
            cell-mediated protective immunity against blood-borne tumors
  JOURNAL   Immunity 58 (4), 843-860 (2025)
   PUBMED   40139188
REFERENCE   3  (residues 1 to 322)
  AUTHORS   Lai,Y.G., Liao,H.T., Chen,Y.H., Huang,S.W., Liou,Y.H., Wu,Z.Q. and
            Liao,N.S.
  TITLE     cGAS and STING in Host Myeloid Cells Are Essential for Effective
            Cyclophosphamide Treatment of Advanced Breast Cancer
  JOURNAL   Cancers (Basel) 17 (7), 1130 (2025)
   PUBMED   40227734
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 322)
  AUTHORS   Schienstock,D., Hor,J.L., Devi,S. and Mueller,S.N.
  TITLE     Cecelia: a multifunctional image analysis toolbox for decoding
            spatial cellular interactions and behaviour
  JOURNAL   Nat Commun 16 (1), 1931 (2025)
   PUBMED   39994207
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 322)
  AUTHORS   Bullock,C.B., Wang,L., Ware,B.C., Wagoner,N., Ohara,R.A.,
            Liu,T.-T., Desai,P., Peters,B., Murphy,K.M., Handley,S.A.,
            Morrison,T.E. and Diamond,M.S.
  TITLE     Type I interferon signaling in dendritic cells limits direct
            antigen presentation and CD8+ T cell responses against an
            arthritogenic alphavirus
  JOURNAL   mBio 15 (12), e0293024 (2024)
   PUBMED   39535221
REFERENCE   6  (residues 1 to 322)
  AUTHORS   Crozat,K., Tamoutounour,S., Vu Manh,T.P., Fossum,E., Luche,H.,
            Ardouin,L., Guilliams,M., Azukizawa,H., Bogen,B., Malissen,B.,
            Henri,S. and Dalod,M.
  TITLE     Cutting edge: expression of XCR1 defines mouse lymphoid-tissue
            resident and migratory dendritic cells of the CD8alpha+ type
  JOURNAL   J Immunol 187 (9), 4411-4415 (2011)
   PUBMED   21948982
REFERENCE   7  (residues 1 to 322)
  AUTHORS   Yamazaki,C., Miyamoto,R., Hoshino,K., Fukuda,Y., Sasaki,I.,
            Saito,M., Ishiguchi,H., Yano,T., Sugiyama,T., Hemmi,H., Tanaka,T.,
            Hamada,E., Hirashima,T., Amakawa,R., Fukuhara,S., Nomura,S., Ito,T.
            and Kaisho,T.
  TITLE     Conservation of a chemokine system, XCR1 and its ligand, XCL1,
            between human and mice
  JOURNAL   Biochem Biophys Res Commun 397 (4), 756-761 (2010)
   PUBMED   20541533
  REMARK    GeneRIF: The expression patterns of XCR1 and XCL1 were conserved in
            human and mice blood cells, including certain dendritic cell
            subsets.
REFERENCE   8  (residues 1 to 322)
  AUTHORS   Crozat,K., Guiton,R., Contreras,V., Feuillet,V., Dutertre,C.A.,
            Ventre,E., Vu Manh,T.P., Baranek,T., Storset,A.K., Marvel,J.,
            Boudinot,P., Hosmalin,A., Schwartz-Cornil,I. and Dalod,M.
  TITLE     The XC chemokine receptor 1 is a conserved selective marker of
            mammalian cells homologous to mouse CD8alpha+ dendritic cells
  JOURNAL   J Exp Med 207 (6), 1283-1292 (2010)
   PUBMED   20479118
  REMARK    GeneRIF: XCR1 constitutes the first conserved specific marker for
            cell subsets homologous to mouse CD8alpha+ dendritic cells in
            higher vertebrates.
REFERENCE   9  (residues 1 to 322)
  AUTHORS   Dorner,B.G., Dorner,M.B., Zhou,X., Opitz,C., Mora,A., Guttler,S.,
            Hutloff,A., Mages,H.W., Ranke,K., Schaefer,M., Jack,R.S., Henn,V.
            and Kroczek,R.A.
  TITLE     Selective expression of the chemokine receptor XCR1 on
            cross-presenting dendritic cells determines cooperation with CD8+ T
            cells
  JOURNAL   Immunity 31 (5), 823-833 (2009)
   PUBMED   19913446
REFERENCE   10 (residues 1 to 322)
  AUTHORS   Yoshida,T., Izawa,D., Nakayama,T., Nakahara,K., Kakizaki,M.,
            Imai,T., Suzuki,R., Miyasaka,M. and Yoshie,O.
  TITLE     Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor
  JOURNAL   FEBS Lett 458 (1), 37-40 (1999)
   PUBMED   10518929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC242682.3.
            
            On Feb 19, 2025 this sequence version replaced NP_035928.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040878.1, AK089908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.71 cM"
     Protein         1..322
                     /product="chemokine XC receptor 1"
                     /note="SCM1 receptor; lymphotactin receptor; XC chemokine
                     receptor 1; C motif-1/lymphotactin receptor; chemokine (C
                     motif) XC receptor 1"
                     /calculated_mol_wt=37177
     Region          28..290
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Site            28..55
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Region          30..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341337"
     Region          63..84
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341337"
     Site            66..85
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Region          98..120
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341337"
     Site            99..120
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Site            138..162
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Region          143..159
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341337"
     Region          178..201
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341337"
     Site            186..204
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Region          219..241
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341337"
     Site            221..243
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     Region          258..283
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341337"
     Site            260..283
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R0M1.1)"
     CDS             1..322
                     /gene="Xcr1"
                     /gene_synonym="Ccxcr1; Gpr5; mXcr1"
                     /coded_by="NM_011798.5:121..1089"
                     /db_xref="GeneID:23832"
                     /db_xref="MGI:MGI:1346338"
ORIGIN      
        1 messtafydy hdklsllcen nviffstist ivlyslvfll slvgnslvlw vlvkyenles
       61 ltnifilnlc lsdlmfscll pvlisaqwsw flgdffckff nmifgislys siffltimti
      121 hrylsvvspi stlgihtlrc rvlvtscvwa asilfsipda vfhkvislnc kysehhgfla
      181 svyqhniffl lsmgiilfcy vqilrtlfrt rsrqrhrtvr liftvvvayf lswapynltl
      241 flktgiiqqs ceslqqldia miicrhlafs hccfnpvlyv fvgikfrrhl khlfqqvwlc
      301 rktsstvpcs pgtftyegps fy
//
LOCUS       NP_573474               1050 aa            linear   ROD 27-AUG-2025
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_573474 XP_918297
VERSION     NP_573474.1
DBSOURCE    REFSEQ: accession NM_133211.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Rasile,M., Sommariva,M., Menegola,E., Di Renzo,F., Anselmi,M.,
            Sfondrini,L., Barajon,I. and Arnaboldi,F.
  TITLE     TLR7 expression patterns in mouse eye development and adult ocular
            tissues
  JOURNAL   Int J Dev Biol 69 (2), 101-107 (2025)
   PUBMED   40521682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Sato,R., Liu,K., Shibata,T., Hoshino,K., Yamaguchi,K., Miyazaki,T.,
            Hiranuma,R., Fukui,R., Motoi,Y., Fukuda-Ohta,Y., Zhang,Y.,
            Reuter,T., Ishida,Y., Kondo,T., Chiba,T., Asahara,H., Taoka,M.,
            Yamauchi,Y., Isobe,T., Kaisho,T., Furukawa,Y., Latz,E.,
            Nakatani,K., Izumi,Y., Nie,Y., Taniguchi,H. and Miyake,K.
  TITLE     RNase T2 deficiency promotes TLR13-dependent replenishment of
            tissue-protective Kupffer cells
  JOURNAL   J Exp Med 222 (3) (2025)
   PUBMED   39853307
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Greene,T.T., Jo,Y., Chiale,C., Macal,M., Fang,Z., Khatri,F.S.,
            Codrington,A.L., Kazane,K.R., Akbulut,E., Swaminathan,S.,
            Fujita,Y., Fitzgerald-Bocarsly,P., Cordes,T., Metallo,C.,
            Scott,D.A. and Zuniga,E.I.
  TITLE     Metabolic deficiencies underlie reduced plasmacytoid dendritic cell
            IFN-I production following viral infection
  JOURNAL   Nat Commun 16 (1), 1460 (2025)
   PUBMED   39920132
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Yang,Y., Treger,R.S., Hernandez-Bird,J., Lu,P., Mao,T. and
            Iwasaki,A.
  TITLE     A B cell screen against endogenous retroviruses identifies
            glycan-reactive IgM that recognizes a broad array of enveloped
            viruses
  JOURNAL   Sci Immunol 9 (101), eadd6608 (2024)
   PUBMED   39514636
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Wang,C., Khatun,M.S., Ellsworth,C.R., Chen,Z., Islamuddin,M.,
            Nisperuza Vidal,A.K., Afaque Alam,M., Liu,S., Mccombs,J.E.,
            Maness,N.J., Blair,R.V., Kolls,J.K. and Qin,X.
  TITLE     Deficiency of Tlr7 and Irf7 in mice increases the severity of
            COVID-19 through the reduced interferon production
  JOURNAL   Commun Biol 7 (1), 1162 (2024)
   PUBMED   39289468
  REMARK    GeneRIF: Deficiency of Tlr7 and Irf7 in mice increases the severity
            of COVID-19 through the reduced interferon production.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold,S.S., Kaisho,T., Hemmi,H., Akira,S. and Reis e Sousa,C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield,G., Ramanathan,M., Hasko,G., Vogel,S.N.,
            Salzman,A.L., Boons,G.J. and Leibovich,S.J.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi,H., Kaisho,T., Takeuchi,O., Sato,S., Sanjo,H., Hoshino,K.,
            Horiuchi,T., Tomizawa,H., Takeda,K. and Akira,S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1 and BY543663.1.
            
            On Dec 7, 2005 this sequence version replaced XP_918297.1.
            
            Transcript Variant: This variant (3) lacks two alternate exons in
            the 5' region and initiates translation from an alternate upstream
            start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode
            the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036549.1, AF334942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3187
     mat_peptide     27..1050
                     /product="Toll-like receptor 7. /id=PRO_0000034734"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=118668
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          484..>786
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_133211.4:232..3384"
                     /note="isoform a precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS30531.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_034566                143 aa            linear   ROD 27-AUG-2025
DEFINITION  histone H2AX [Mus musculus].
ACCESSION   NP_034566
VERSION     NP_034566.1
DBSOURCE    REFSEQ: accession NM_010436.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 143)
  AUTHORS   Zhao,B.W., Zhang,Y.N., Meng,T.G., Xu,Y.H., Lu,Y.K., Sun,S.M.,
            Guo,J.N., Yang,X.M. and Wang,Z.B.
  TITLE     Re-establishment of H3K9me2 eliminates the transcriptional
            inhibition of ST18 on meiotic genes and orchestrates female germ
            cell development
  JOURNAL   Nucleic Acids Res 53 (13) (2025)
   PUBMED   40650982
REFERENCE   2  (residues 1 to 143)
  AUTHORS   Jaber-Hijazi,F., Arnold,R., Swaminathan,K., Gilroy,K., Wenzel,A.T.,
            Lagnado,A., Kirschner,K., Robertson,N., Reid,C., Fullarton,N.,
            Pawlikowski,J., Rai,T.S., Baranyk,I., Shi,C.H., Yip,K.Y., Blyth,K.,
            Mesirov,J.P., Harris,M.L., Passos,J.F., Machesky,L.M. and
            Adams,P.D.
  TITLE     Inactivation of Histone Chaperone HIRA Unmasks a Link Between
            Normal Embryonic Development of Melanoblasts and Maintenance of
            Adult Melanocyte Stem Cells
  JOURNAL   Aging Cell 24 (7), e70070 (2025)
   PUBMED   40669469
REFERENCE   3  (residues 1 to 143)
  AUTHORS   Glaser,J., Cova,G., Fauler,B., Prada-Medina,C.A., Stanislas,V.,
            Phan,M.H.Q., Schopflin,R., Aktas,Y., Franke,M., Andrey,G.,
            Bartzoka,N., Paliou,C., Laupert,V., Chan,W.L., Wittler,L.,
            Mielke,T. and Mundlos,S.
  TITLE     Enhancer adoption by an LTR retrotransposon generates viral-like
            particles, causing developmental limb phenotypes
  JOURNAL   Nat Genet 57 (7), 1766-1776 (2025)
   PUBMED   40634706
REFERENCE   4  (residues 1 to 143)
  AUTHORS   Wang,Y., Kaiser,S., Martin-Gonzalez,J., Li,Y., Rasmussen,L.J.,
            Lopez-Contreras,A.J., Bizard,A.H. and Hickson,I.D.
  TITLE     Functional analysis of pathological mutations in DNA topoisomerase
            3A
  JOURNAL   Cell Rep 44 (6), 115764 (2025)
   PUBMED   40450688
REFERENCE   5  (residues 1 to 143)
  AUTHORS   Yue,W.Y., Zhang,Y., Jiang,T.X. and Qiu,X.B.
  TITLE     Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors
            Rpn10 and Rpn13 in Germ Cell Formation and Fertility
  JOURNAL   Cells 14 (10), 696 (2025)
   PUBMED   40422199
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 143)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   7  (residues 1 to 143)
  AUTHORS   Yagi,H., Kato,T., Nagata,T., Habu,T., Nozaki,M., Matsushiro,A.,
            Nishimune,Y. and Morita,T.
  TITLE     Regulation of the mouse histone H2A.X gene promoter by the
            transcription factor E2F and CCAAT binding protein
  JOURNAL   J Biol Chem 270 (32), 18759-18765 (1995)
   PUBMED   7642525
REFERENCE   8  (residues 1 to 143)
  AUTHORS   Nagata,T., Kato,T., Morita,T., Nozaki,M., Kubota,H., Yagi,H. and
            Matsushiro,A.
  TITLE     Polyadenylated and 3' processed mRNAs are transcribed from the
            mouse histone H2A.X gene
  JOURNAL   Nucleic Acids Res 19 (9), 2441-2447 (1991)
   PUBMED   2041781
REFERENCE   9  (residues 1 to 143)
  AUTHORS   Pantazis,P. and Bonner,W.M.
  TITLE     Quantitative determination of histone modification. H2A acetylation
            and phosphorylation
  JOURNAL   J Biol Chem 256 (9), 4669-4675 (1981)
   PUBMED   7217105
REFERENCE   10 (residues 1 to 143)
  AUTHORS   West,M.H. and Bonner,W.M.
  TITLE     Histone 2A, a heteromorphous family of eight protein species
  JOURNAL   Biochemistry 19 (14), 3238-3245 (1980)
   PUBMED   7407044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010336.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC010336.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Mus musculus"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     Protein         1..143
                     /product="histone H2AX"
                     /note="histone H2A.x; H2a/x; histone 5 protein 2ax; H2A
                     histone family, member X"
                     /calculated_mol_wt=15011
     Region          1..130
                     /region_name="PTZ00017"
                     /note="histone H2A; Provisional"
                     /db_xref="CDD:185399"
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27661.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000269|PubMed:7217105; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:7217105; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            6
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            10
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            37
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by CREBBP and EP300.
                     /evidence=ECO:0000269|PubMed:20488183; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Region          121..143
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27661.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Region          140..141
                     /region_name="[ST]-Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P27661.2)"
     Site            140
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ATM, ATR and PRKDC.
                     /evidence=ECO:0000269|PubMed:11242108,
                     ECO:0000269|PubMed:11571274, ECO:0000269|PubMed:11740565,
                     ECO:0000269|PubMed:12447390, ECO:0000269|PubMed:12660252,
                     ECO:0000269|PubMed:14530383, ECO:0000269|PubMed:15059890,
                     ECO:0000269|PubMed:15580272, ECO:0000269|PubMed:9488723,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     Site            143
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by WSTF.
                     /evidence=ECO:0000269|PubMed:19092802; propagated from
                     UniProtKB/Swiss-Prot (P27661.2)"
     CDS             1..143
                     /gene="H2ax"
                     /gene_synonym="gammaH2ax; H2A.X; H2afx; Hist5-2ax"
                     /coded_by="NM_010436.2:48..479"
                     /db_xref="CCDS:CCDS23105.1"
                     /db_xref="GeneID:15270"
                     /db_xref="MGI:MGI:102688"
ORIGIN      
        1 msgrgktggk arakaksrss raglqfpvgr vhrllrkghy aervgagapv ylaavleylt
       61 aeilelagna ardnkktrii prhlqlairn deelnkllgg vtiaqggvlp niqavllpkk
      121 ssatvgpkap avgkkasqas qey
//
LOCUS       NP_033046                527 aa            linear   ROD 27-AUG-2025
DEFINITION  V(D)J recombination-activating protein 2 [Mus musculus].
ACCESSION   NP_033046
VERSION     NP_033046.1
DBSOURCE    REFSEQ: accession NM_009020.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 527)
  AUTHORS   Pignata,A., Frieser,D., Gonzalez-Fierro,C., Hsiao,C.C.,
            Engelenburg,H.J., Alis,M., Fijalkow,I., Cazaentre,V., Nozeran,L.,
            Miranda-Capet,R., Dufourd,E., Vermeulen,T., Aida,A., Le Coz,C., Van
            Gisbergen,K., Blanchard,N., Hamann,J., Smolders,J., Liblau,R.S. and
            Masson,F.
  TITLE     Tissue-resident memory CD4+ T cells infiltrate the CNS in
            progressive multiple sclerosis and contribute to chronic
            autoimmunity in mice
  JOURNAL   Sci Transl Med 17 (808), eadp8109 (2025)
   PUBMED   40700520
REFERENCE   2  (residues 1 to 527)
  AUTHORS   Kohne,M., Shakiba,M.H., Schmidleithner,L., Schulte-Schrepping,J.,
            Scholz,R., Elmzzahi,T., Sommer,D., Li,Y., Carraro,C., De
            Domenico,E., Wissfeld,J., Handler,K., Hamada,D., Frolov,A.,
            Cheng,X., Baumgart,A.K., Holsten,L., Osei-Sarpong,C., Bourry,S.,
            Thabet,Y., Renken,H., Paulusch,S., Sadlon,T., Buch,T.,
            Wunderlich,F.T., Wickenhauser,C., Alferink,J., Kuhlmann,T.,
            Geyer,M., Bonaguro,L., Barry,S.C., Schultze,J.L. and Beyer,M.D.
  TITLE     Satb1 directs the differentiation of TH17 cells through suppression
            of IL-2 expression
  JOURNAL   Cell Rep 44 (7), 115866 (2025)
   PUBMED   40531625
REFERENCE   3  (residues 1 to 527)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 527)
  AUTHORS   Matsuda,K., Ide,N., Xu,Y., Iijima,A. and Shibuya,A.
  TITLE     Type 1 innate lymphoid cell-immature neutrophil axis suppresses
            acute tissue inflammation
  JOURNAL   Nat Commun 16 (1), 6574 (2025)
   PUBMED   40675953
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 527)
  AUTHORS   Zhao,X., Li,J., Zhang,Y., Hu,L., Wu,D., Wu,J., Lyu,R., Li,P.,
            An,G., Cui,R., Sun,T., Zhu,P., Bai,L., Jiang,C. and Zhong,C.
  TITLE     Elevated nitric oxide during colitis restrains GM-CSF production in
            ILC3 cells via suppressing an AhR-Cyp4f13-NF-kappaB axis
  JOURNAL   Nat Commun 16 (1), 5654 (2025)
   PUBMED   40593752
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 527)
  AUTHORS   Oettinger,M.A.
  TITLE     Activation of V(D)J recombination by RAG1 and RAG2
  JOURNAL   Trends Genet 8 (12), 413-416 (1992)
   PUBMED   1492366
  REMARK    Review article
REFERENCE   7  (residues 1 to 527)
  AUTHORS   Mombaerts,P., Iacomini,J., Johnson,R.S., Herrup,K., Tonegawa,S. and
            Papaioannou,V.E.
  TITLE     RAG-1-deficient mice have no mature B and T lymphocytes
  JOURNAL   Cell 68 (5), 869-877 (1992)
   PUBMED   1547488
REFERENCE   8  (residues 1 to 527)
  AUTHORS   Shinkai,Y., Rathbun,G., Lam,K.P., Oltz,E.M., Stewart,V.,
            Mendelsohn,M., Charron,J., Datta,M., Young,F., Stall,A.M. et al.
  TITLE     RAG-2-deficient mice lack mature lymphocytes owing to inability to
            initiate V(D)J rearrangement
  JOURNAL   Cell 68 (5), 855-867 (1992)
   PUBMED   1547487
REFERENCE   9  (residues 1 to 527)
  AUTHORS   Schatz,D.G., Oettinger,M.A. and Schlissel,M.S.
  TITLE     V(D)J recombination: molecular biology and regulation
  JOURNAL   Annu Rev Immunol 10, 359-383 (1992)
   PUBMED   1590991
  REMARK    Review article
REFERENCE   10 (residues 1 to 527)
  AUTHORS   Banville,D., Rotaru,M. and Boie,Y.
  TITLE     The intracisternal A particle derived solo LTR promoter of the rat
            oncomodulin gene is not present in the mouse gene
  JOURNAL   Genetica 86 (1-3), 85-97 (1992)
   PUBMED   1468649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB654295.1 and AK040375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040375.1, AK031014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 53.87 cM"
     Protein         1..527
                     /product="V(D)J recombination-activating protein 2"
                     /note="recombinase activating gene 2"
                     /calculated_mol_wt=58943
     Region          51..389
                     /region_name="RAG2"
                     /note="Recombination activating protein 2; pfam03089"
                     /db_xref="CDD:427128"
     Region          359..380
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P21784.2)"
     Region          414..491
                     /region_name="RAG2_PHD"
                     /note="RAG2 PHD domain; pfam13341"
                     /db_xref="CDD:404256"
     Site            order(418,442..446,453,476)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277044"
     Region          490..511
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P21784.2)"
     CDS             1..527
                     /gene="Rag2"
                     /gene_synonym="Rag-2"
                     /coded_by="NM_009020.4:248..1831"
                     /db_xref="CCDS:CCDS16462.1"
                     /db_xref="GeneID:19374"
                     /db_xref="MGI:MGI:97849"
ORIGIN      
        1 mslqmvtvgh nialiqpgfs lmnfdgqvff fgqkgwpkrs cptgvfhfdi kqnhlklkpa
       61 ifskdscylp plrypatcsy kgsidsdkhq yiihggktpn nelsdkiyim svacknnkkv
      121 tfrctekdlv gdvpeprygh sidvvysrgk smgvlfggrs ympstqrtte kwnsvadclp
      181 hvflidfefg catsyilpel qdglsfhvsi arndtvyilg ghslasnirp anlyrirvdl
      241 plgtpavnct vlpggisvss ailtqtnnde fvivggyqle nqkrmvcslv slgdntieis
      301 emetpdwtsd ikhskiwfgs nmgngtiflg ipgdnkqams eafyfytlrc seedlsedqk
      361 ivsnsqtste dpgdstpfed seefcfsaea tsfdgddefd tyneddedde svtgywitcc
      421 ptcdvdintw vpfystelnk pamiycshgd ghwvhaqcmd leertlihls egsnkyycne
      481 hvqiaralqt pkrnpplqkp pmkslhkkgs gkvltpakks flrrlfd
//
LOCUS       NP_001412666            1935 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin-7 [Mus musculus].
ACCESSION   NP_001412666
VERSION     NP_001412666.1
DBSOURCE    REFSEQ: accession NM_001425737.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1935)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 1935)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1935)
  AUTHORS   Monteiro,J.P., Saha,D., Spiroski,A.M., Mahesh,S., Kaltzis,P.,
            Nadavallil,A., Janbandhu,V., Murray,N.J., Severi,F., De Pace,A.L.,
            Sanchez-Esteban,S., Rodor,J., Beqqali,A., Bennett,M., Stewart,K.,
            Thomson,A., Hadoke,P.W.F., Markose,D., Wilson-Kanamori,J.R.,
            Henderson,N.C., O'Carroll,D., Quertermous,T., Harvey,R.P., Del
            Monte-Nieto,G. and Baker,A.H.
  TITLE     Loss of conserved long non-coding RNA MIR503HG leads to altered
            NOTCH pathway signalling and left ventricular non-compaction
            cardiomyopathy
  JOURNAL   Cardiovasc Res 121 (7), 988-991 (2025)
   PUBMED   40183391
REFERENCE   4  (residues 1 to 1935)
  AUTHORS   Shi,H., Li,J., Li,F., Yu,H., Zhang,F., Wu,T., Yang,L., Li,Y.,
            Hu,R., Chen,M., Sg,N., Zhuang,X., Feng,S., Zhu,L. and Duan,R.
  TITLE     Vitamin C-Dependent Intergenerational Inheritance of Enhanced
            Endurance Performance Following Maternal Exercise
  JOURNAL   Adv Sci (Weinh) 12 (13), e2408912 (2025)
   PUBMED   39921869
REFERENCE   5  (residues 1 to 1935)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Lu,Y., Liu,E.,
            Kim,I.M., Jiao,K., Weintraub,N.L., Zhou,J., Li,J. and Su,H.
  TITLE     Neddylation drives myofibrillogenesis in the developing heart
  JOURNAL   FASEB J 38 (24), e70260 (2024)
   PUBMED   39698930
REFERENCE   6  (residues 1 to 1935)
  AUTHORS   Watkins,H., Rosenzweig,A., Hwang,D.S., Levi,T., McKenna,W.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Characteristics and prognostic implications of myosin missense
            mutations in familial hypertrophic cardiomyopathy
  JOURNAL   N Engl J Med 326 (17), 1108-1114 (1992)
   PUBMED   1552912
REFERENCE   7  (residues 1 to 1935)
  AUTHORS   Parker-Thornburg,J., Bauer,B., Palermo,J. and Robbins,J.
  TITLE     Structural and developmental analysis of two linked myosin heavy
            chain genes
  JOURNAL   Dev Biol 150 (1), 99-107 (1992)
   PUBMED   1371481
REFERENCE   8  (residues 1 to 1935)
  AUTHORS   Smith,T.H. and Miller,J.B.
  TITLE     Distinct myogenic programs of embryonic and fetal mouse muscle
            cells: expression of the perinatal myosin heavy chain isoform in
            vitro
  JOURNAL   Dev Biol 149 (1), 16-26 (1992)
   PUBMED   1728586
REFERENCE   9  (residues 1 to 1935)
  AUTHORS   Sanchez,A., Jones,W.K., Gulick,J., Doetschman,T. and Robbins,J.
  TITLE     Myosin heavy chain gene expression in mouse embryoid bodies. An in
            vitro developmental study
  JOURNAL   J Biol Chem 266 (33), 22419-22426 (1991)
   PUBMED   1939265
REFERENCE   10 (residues 1 to 1935)
  AUTHORS   Robbins,J., Gulick,J., Sanchez,A., Howles,P. and Doetschman,T.
  TITLE     Mouse embryonic stem cells express the cardiac myosin heavy chain
            genes during development in vitro
  JOURNAL   J Biol Chem 265 (20), 11905-11909 (1990)
   PUBMED   1694848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025533.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.14455.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.01 cM"
     Protein         1..1935
                     /product="myosin-7"
                     /note="myosin heavy chain 7; myosin heavy chain, cardiac
                     muscle, fetal"
                     /calculated_mol_wt=222749
     Region          37..1432
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          99..766
                     /region_name="MYSc_class_II"
                     /note="class II myosins, motor domain; cd01377"
                     /db_xref="CDD:276951"
     Site            order(126..134,178..185,233..243,461..466)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276951"
     Site            126..134
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276951"
     Site            129
                     /site_type="methylation"
                     /note="N6,N6,N6-trimethyllysine. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            178..185
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276951"
     Site            233..243
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276951"
     Site            378
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            461..466
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276951"
     Site            490..513
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276951"
     Region          655..677
                     /region_name="Actin-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            697..706
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276951"
     Site            order(709..725,755..766)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276951"
     Region          757..771
                     /region_name="Actin-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Region          1173..1930
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            1269
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q02566; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1282
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1308
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1309
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1510
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02564; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1513
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Region          1915..1935
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     CDS             1..1935
                     /gene="Myh7"
                     /gene_synonym="B-MHC; beta-MHC; betaMHC; MYH-beta/slow;
                     Myhc-b; myHC-beta; MyHC-I; myHC-slow; Myhcb"
                     /coded_by="NM_001425737.1:103..5910"
                     /db_xref="GeneID:140781"
                     /db_xref="MGI:MGI:2155600"
ORIGIN      
        1 madaemaafg aaapflrkse kerleaqtrp fdlkkdvfvp ddkeefvkak ivsreggkvt
       61 aetengktvt vkedqvmqqn ppkfdkiedm amltflhepa vlynlkerya swmiytysgl
      121 fcvtvnpykw lpvynaevva ayrgkkrsea pphifsisdn ayqymltdre nqsilitges
      181 gagktvntkr viqyfaviaa igdrskkdqt pgkgtledqi iqanpaleaf gnaktvrndn
      241 ssrfgkfiri hfgatgklas adietyllek srvifqlkae rdyhifyqil snkkpelldm
      301 llitnnpydy afisqgettv asiddseelm atdsafdvlg ftpeeknsiy kltgaimhfg
      361 nmkfkqkqre eqaepdgtee adksaylmgl nsadllkglc hprvkvgney vtkgqnvqqv
      421 syaigalaks vyekmfnwmv trinatletk qprqyfigvl diagfeifdf nsfeqlcinf
      481 tneklqqffn hhmfvleqee ykkegiewtf idfgmdlqac idliekpmgi msileeecmf
      541 pkatdmtfka klydnhlgks nnfqkprnvk gkqeahfslv hyagtvdyni lgwlqknkdp
      601 lnetvvglyq ksslkllsnl fanyagadap adkgkgkakk gssfqtvsal hrenlnklmt
      661 nlrsthphfv rciipnetks pgvmdnplvm hqlrcngvle giricrkgfp nrilygdfrq
      721 ryrilnpaai pegqfidsrk gaekllgsld idhnqykfgh tkvffkagll glleemrder
      781 lsriitriqa qsrgvlsrme fkkllerrds lliiqwnira fmgvknwpwm klyfkikpll
      841 ksaetekema tmkeefgrvk daleksearr keleekmvsl lqekndlqlq vqaeqdnlad
      901 aeercdqlik nkiqleakvk emterledee emnaeltakk rkledecsel krdiddlelt
      961 lakvekekha tenkvknlte emagldeiiv kltkekkalq eahqqalddl qaeedkvntl
     1021 tkakvkleqq vddlegsleq ekkvrmdler akrklegdlk ltqesimdle ndkqqlderl
     1081 kkkdfelnal nariedeqal gsqlqkklke lqarieelee eleaertara kveklrsdls
     1141 releeiserl eeaggatsvq iemnkkreae fqkmrrdlee atlqheataa alrkkhadsv
     1201 aelgeqidnl qrvkqkleke ksefkleldd vtsnmeqiik akanlekmcr tledqmnehr
     1261 skaeetqrsv ndltsqrakl qtengelsrq ldekealisq ltrgkltytq qledlkrqle
     1321 eevkaknala halqsarhdc dllreqyeee teakaelqrv lskansevaq wrtkyetdai
     1381 qrteeleeak kklaqrlqda eeaveavnak csslektkhr lqneiedlmv dversnaaaa
     1441 aldkkqrnfd kilaewkqky eesqseless qkearslste lfklknayee slehletfkr
     1501 enknlqeeis dlteqlgstg ksihelekir kqleaeklel qsaleeaeas leheegkilr
     1561 aqlefnqika eierklaekd eemeqakrnh lrmvdslqts ldaetrsrne alrvkkkmeg
     1621 dlnemeiqls hanrmaaeaq kqvkslqsll kdtqiqldda vranddlken iaiverrnnl
     1681 lqaeleelra vveqtersrk laeqeliets ervqllhsqn tslinqkkkm dadlsqlqte
     1741 veeavqecrn aeekakkait daammaeelk keqdtsahle rmkknmeqti kdlqhrldea
     1801 eqialkggkk qlqklearvr eleneleaeq krnaesvkgm rkserrikel tyqteedrkn
     1861 llrlqdlvdk lqlkvkaykr qaeeaeeqan tnlskfrkvq heldeaeera diaesqvnkl
     1921 raksrdigak glnee
//
LOCUS       NP_031830               1426 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 2 isoform 1 [Mus musculus].
ACCESSION   NP_031830
VERSION     NP_031830.2
DBSOURCE    REFSEQ: accession NM_007804.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1426)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1426)
  AUTHORS   Iulianella,A., Vanden Heuvel,G. and Trainor,P.
  TITLE     Dynamic expression of murine Cux2 in craniofacial, limb, urogenital
            and neuronal primordia
  JOURNAL   Gene Expr Patterns 3 (5), 571-577 (2003)
   PUBMED   12971989
REFERENCE   7  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Quaggin,S.E. and Igarashi,P.
  TITLE     A unique variant of a homeobox gene related to Drosophila cut is
            expressed in mouse testis
  JOURNAL   Biol Reprod 55 (4), 731-739 (1996)
   PUBMED   8879483
REFERENCE   8  (residues 1 to 1426)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Bodmer,R., McConnell,K.R., Nagami,G.T. and
            Igarashi,P.
  TITLE     Expression of a cut-related homeobox gene in developing and
            polycystic mouse kidney
  JOURNAL   Kidney Int 50 (2), 453-461 (1996)
   PUBMED   8840273
REFERENCE   10 (residues 1 to 1426)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140353.2 and AC113302.13.
            
            On Jan 11, 2004 this sequence version replaced NP_031830.1.
            
            Summary: This gene is a member of the Cut family of transcription
            factors that have multiple DNA binding domains and regulate cell
            proliferation and differentiation. This gene is primarily expressed
            in nervous tissues where it controls the proliferation of neuronal
            precursors, and may play a role in organogenesis earlier during
            embryonic development. Mice lacking the encoded protein exhibit
            smaller spinal cords with deficits in neural progenitor development
            as well as in neuroblast and interneuron differentiation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065113.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.02 cM"
     Protein         1..1426
                     /product="homeobox protein cut-like 2 isoform 1"
                     /note="homeobox protein cut-like 2; homeobox protein
                     Cux-2"
                     /calculated_mol_wt=154533
     Region          77..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14529; propagated from
                     UniProtKB/Swiss-Prot (P70298.2)"
     Region          <116..>316
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          351..419
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          460..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          487..563
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          599..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          653..676
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          743..769
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          833..906
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          904..977
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          988..1064
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1114..1170
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1177..1392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     CDS             1..1426
                     /gene="Cux2"
                     /gene_synonym="1700051K22Rik; Cutl2; Cux-2"
                     /coded_by="NM_007804.3:492..4772"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39251.1"
                     /db_xref="GeneID:13048"
                     /db_xref="MGI:MGI:107321"
ORIGIN      
        1 mvapvlksfq aevvalskrs reaeaaflsv ykqlieapdp vpsfevartl ddrlqrpsfd
       61 psgqrlqdvh iawkrcpepp sareqnegtc ptghtpangn hlpgpedtlv tdtllqknea
      121 erqkglqevh itlaarlgea eekikvlhsa lkatqtelle lrrkydeeaa skadevglim
      181 tnlekanqra eaaqrevesl reqlasvnss irlaccspqg psgekvsfal csgprleaal
      241 askdreilrl lkdaqqlrhs lqeleevsan qiadlerqla akseaieklq ekleaqadye
      301 eiktelsilr amklasstcs lpqtlakpdd pllvakdvff ptqkfllekp allaspeedp
      361 seddsikgsl gteppyppql ppppgpedpl spspaqpllg pslgpdgprt fslspfpsla
      421 pgerlagdsl lskhmmgpaa fkgetgnlla fpptfyggak ppsapaasvp cpeptgapea
      481 vdgagpeeeq ldtaeiafqv keqllkhnig qrvfghyvlg lsqgsvseil arpkpwrklt
      541 vkgkepfikm kqflsdeqnv lalrtiqvrq rgsitprirt petgsddaik sileqakkei
      601 esqkggeskn spasvsipng tassstseda iknileqarr emqaqqqall emesgprgrs
      661 vppspperps patasqngal tcvkqedggg gsgssstvqa plavlspaaf vqriirkvks
      721 eigdagyfdh hwasdrglls rpyasvspsl sssssysgqp ngrawprgde atiapedeaa
      781 mgedeaprvg elkaeagape vgggrlpyyp ayvprtlkpt vppltpeqye lymyrevdtl
      841 eltrqvkekl akngicqrif gekvlglsqg svsdmlsrpk pwskltqkgr epfirmqlwl
      901 sdqlgqgqgq aptqqpsasq aspteptssp spppsptepe ktsqeplgls lesskenqqp
      961 egrassslgg kpfsssqaag giqemvamsp eldtysitkr vkevltdnnl gqrlfgesil
     1021 gltqgsvsdl lsrpkpwhkl slkgrepfvr mqlwlsdphn veklrdmkkl ekkaylkrry
     1081 gligtgsdse spaahsecps pclqpqelsl mqakkprvvl apaekealrk ayqlepypsq
     1141 qtiellsfql nlktntvinw fhnyrsrmrr emlvegtqdd pdfdpsggpn vltpghthre
     1201 ptpqspdset edqkppmksl elqepegplq raapdralvk ikqeeglevd gdsqpqdvgd
     1261 pdrgqdgpke ehthplgnsd lselapgpfl sgtpnpdcps lhnpqekgtg eqvhseplsf
     1321 kstsessccs legppnspsv isspdlttcv spapsssapi spslpgappa kvpstsptgd
     1381 taaalhpstk vnpnlqrrhe kmanlnsiiy rleraanree vlewef
//
LOCUS       NP_035558                206 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform a [Mus musculus].
ACCESSION   NP_035558 XP_130450
VERSION     NP_035558.1
DBSOURCE    REFSEQ: accession NM_011428.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            On Dec 17, 2003 this sequence version replaced XP_130450.1.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1
            and 3 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078038.1, BC018249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..206
                     /product="synaptosomal-associated protein 25 isoform a"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=23184
     Region          1..75
                     /region_name="Interaction with CENPF.
                     /evidence=ECO:0000269|PubMed:16672379"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..142
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          111..120
                     /region_name="Interaction with ZDHHC17.
                     /evidence=ECO:0000250|UniProtKB:P60880"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC and PKA.
                     /evidence=ECO:0000269|PubMed:12459461,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Region          143..201
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(143,145..146,149..154,156..157,160..161,163..165,
                     167..168,171..172,174..175,177..182,184..185,188,191,195,
                     198,201)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            174
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     Site            180..181
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type E (BoNT/E).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:12459461; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            197..198
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type A (BoNT/A, botA).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     CDS             1..206
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_011428.4:210..830"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16793.1"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqleri
       61 eegmdqinkd mkeaeknltd lgkfcglcvc pcnklkssda ykkawgnnqd gvvasqparv
      121 vdereqmais ggfirrvtnd arenemdenl eqvsgiignl rhmaldmgne idtqnrqidr
      181 imekadsnkt rideanqrat kmlgsg
//
LOCUS       NP_031852                751 aa            linear   ROD 27-AUG-2025
DEFINITION  dachshund homolog 1 isoform 1 [Mus musculus].
ACCESSION   NP_031852
VERSION     NP_031852.1
DBSOURCE    REFSEQ: accession NM_007826.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Mohanakrishnan,V., Sivaraj,K.K., Jeong,H.W., Bovay,E.,
            Dharmalingam,B., Bixel,M.G., Dinh,V.V., Petkova,M., Paredes
            Ugarte,I., Kuo,Y.T., Gurusamy,M., Raftrey,B., Chu,N.T.L., Das,S.,
            Rios Coronado,P.E., Stehling,M., Savendahl,L., Chagin,A.S.,
            Makinen,T., Red-Horse,K. and Adams,R.H.
  TITLE     Specialized post-arterial capillaries facilitate adult bone
            remodelling
  JOURNAL   Nat Cell Biol 26 (12), 2020-2034 (2024)
   PUBMED   39528700
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Davis,R.J., Shen,W., Heanue,T.A. and Mardon,G.
  TITLE     Mouse Dach, a homologue of Drosophila dachshund, is expressed in
            the developing retina, brain and limbs
  JOURNAL   Dev Genes Evol 209 (9), 526-536 (1999)
   PUBMED   10502109
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Hammond,K.L., Lettice,L.A., Hill,R.E., Lee,M., Boyle,S. and
            Hanson,I.M.
  TITLE     Human (DACH) and mouse (Dach) homologues of Drosophila dachshund
            map to chromosomes 13q22 and 14E3, respectively
  JOURNAL   Genomics 55 (2), 252-253 (1999)
   PUBMED   9933575
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Caubit,X., Thangarajah,R., Theil,T., Wirth,J., Nothwang,H.G.,
            Ruther,U. and Krauss,S.
  TITLE     Mouse Dac, a novel nuclear factor with homology to Drosophila
            dachshund shows a dynamic expression in the neural crest, the eye,
            the neocortex, and the limb bud
  JOURNAL   Dev Dyn 214 (1), 66-80 (1999)
   PUBMED   9915577
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Hammond,K.L., Hanson,I.M., Brown,A.G., Lettice,L.A. and Hill,R.E.
  TITLE     Mammalian and Drosophila dachshund genes are related to the Ski
            proto-oncogene and are expressed in eye and limb
  JOURNAL   Mech Dev 74 (1-2), 121-131 (1998)
   PUBMED   9651501
  REMARK    GeneRIF: The mouse dachshund gene is related to the Ski
            proto-oncogene and is expressed in eye and limb.
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Stewart,G.J., Savioz,A. and Davies,R.W.
  TITLE     Sequence analysis of 497 mouse brain ESTs expressed in the
            substantia nigra
  JOURNAL   Genomics 39 (2), 147-153 (1997)
   PUBMED   9027501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122309.5, AC132370.9, AC126264.3 and AC144673.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102547.1, AF090436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 48.25 cM"
     Protein         1..751
                     /product="dachshund homolog 1 isoform 1"
                     /note="dachshund homolog 1; dachshund 1"
                     /calculated_mol_wt=77841
     Region          1..178
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          179..273
                     /region_name="DHD_Dac"
                     /note="Dachshund-homology domain found in the retinal
                     determination protein Dachshund and similar proteins;
                     cd21081"
                     /db_xref="CDD:410784"
     Region          182..377
                     /region_name="Interaction with SIX6 and HDAC3.
                     /evidence=ECO:0000269|PubMed:12130660"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          182..268
                     /region_name="DACHbox-N"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          273..295
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          351..393
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          467..525
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Site            484
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          537..556
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          609..689
                     /region_name="DACHbox-C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     Region          620..699
                     /region_name="Interaction with SIN3A.
                     /evidence=ECO:0000269|PubMed:12130660"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QYB2.1)"
     CDS             1..751
                     /gene="Dach1"
                     /gene_synonym="Dac; Dach"
                     /coded_by="NM_007826.4:464..2719"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36994.1"
                     /db_xref="GeneID:13134"
                     /db_xref="MGI:MGI:1277991"
ORIGIN      
        1 mavpaalipp tqlvppqppi stsasssgtt tstssatssp apsigppass gptlfrpepi
       61 assasssaaa tvtspggggg gsgggggsgg ngggggsncn pslaagssgg gvsaggggas
      121 stpitastgs ssssssssss ssssssssss sssssscgpl pgkpvystps pventpqnne
      181 ckmvdlrgak vasftvegce liclpqafdl flkhlvgglh tvytklkrle itpvvcnveq
      241 vrilrglgai qpgvnrckli srkdfetlyn dctnassrpg rppkrtqsvt spenshimph
      301 svpglmspgi ipptgltaaa aaaaaatnaa iaeamkvkki kleamsnyha snnqhgadse
      361 ngdmnssvgs sggswdketl hsppsqgsqa pvaharmpaa fslpvshpln hlqhshlppn
      421 glelpfmmmp hplipvslpp asvtmamsqm nhlstianma aaaqvqspps rvetsviker
      481 vpdspspaps leegrrpgsh psshrsssvs sspartesss dripvhqngl smnqmlmgls
      541 pnvlpgpkeg dlaghdmghe skrihiekde tplstptard sidklsltgh gqplppgfps
      601 pflfpdglss ietlltniqg llkvaidnar aqekqvqlek telkmdflre relretlekq
      661 lameqknrai vqkrlkkekk akrklqeale fetkrreqae qtlkqaasad slrvlndslt
      721 peieadrsgg radaertiqd grlylkttvm y
//
LOCUS       NP_001298049            1094 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA mismatch repair protein Msh3 isoform 2 [Mus musculus].
ACCESSION   NP_001298049 XP_006517604
VERSION     NP_001298049.1
DBSOURCE    REFSEQ: accession NM_001311120.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1094)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell 188 (6), 1524-1544 (2025)
   PUBMED   39938516
REFERENCE   2  (residues 1 to 1094)
  AUTHORS   Bunting,E.L., Donaldson,J., Cumming,S.A., Olive,J., Broom,E.,
            Miclaus,M., Hamilton,J., Tegtmeyer,M., Zhao,H.T., Brenton,J.,
            Lee,W.S., Handsaker,R.E., Li,S., Ford,B., Ryten,M., McCarroll,S.A.,
            Kordasiewicz,H.B., Monckton,D.G., Balmus,G., Flower,M. and
            Tabrizi,S.J.
  TITLE     Antisense oligonucleotide-mediated MSH3 suppression reduces somatic
            CAG repeat expansion in Huntington's disease iPSC-derived striatal
            neurons
  JOURNAL   Sci Transl Med 17 (785), eadn4600 (2025)
   PUBMED   39937881
REFERENCE   3  (residues 1 to 1094)
  AUTHORS   Aldous,S.G., Smith,E.J., Landles,C., Osborne,G.F.,
            Canibano-Pico,M., Nita,I.M., Phillips,J., Zhang,Y., Jin,B.,
            Hirst,M.B., Benn,C.L., Bond,B.C., Edelmann,W., Greene,J.R. and
            Bates,G.P.
  TITLE     A CAG repeat threshold for therapeutics targeting somatic
            instability in Huntington's disease
  JOURNAL   Brain 147 (5), 1784-1798 (2024)
   PUBMED   38387080
REFERENCE   4  (residues 1 to 1094)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 1094)
  AUTHORS   Driscoll,R., Hampton,L., Abraham,N.A., Larigan,J.D., Joseph,N.F.,
            Hernandez-Vega,J.C., Geisler,S., Yang,F.C., Deninger,M., Tran,D.T.,
            Khatri,N., Godinho,B.M.D.C., Kinberger,G.A., Montagna,D.R.,
            Hirst,W.D., Guardado,C.L., Glajch,K.E., Arnold,H.M.,
            Gallant-Behm,C.L. and Weihofen,A.
  TITLE     Dose-dependent reduction of somatic expansions but not Htt
            aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111
            mice
  JOURNAL   Sci Rep 14 (1), 2061 (2024)
   PUBMED   38267530
  REMARK    GeneRIF: Dose-dependent reduction of somatic expansions but not Htt
            aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111
            mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1094)
  AUTHORS   Liu,K., Niu,L., Linton,J.P. and Crouse,G.F.
  TITLE     Characterization of the mouse Rep-3 gene: sequence similarities to
            bacterial and yeast mismatch-repair proteins
  JOURNAL   Gene 147 (2), 169-177 (1994)
   PUBMED   7926796
REFERENCE   7  (residues 1 to 1094)
  AUTHORS   Smith,M.L., Mitchell,P.J. and Crouse,G.F.
  TITLE     Analysis of the mouse Dhfr/Rep-3 major promoter region by using
            linker-scanning and internal deletion mutations and DNase I
            footprinting
  JOURNAL   Mol Cell Biol 10 (11), 6003-6012 (1990)
   PUBMED   2233729
REFERENCE   8  (residues 1 to 1094)
  AUTHORS   Linton,J.P., Yen,J.Y., Selby,E., Chen,Z., Chinsky,J.M., Liu,K.,
            Kellems,R.E. and Crouse,G.F.
  TITLE     Dual bidirectional promoters at the mouse dhfr locus: cloning and
            characterization of two mRNA classes of the divergently transcribed
            Rep-1 gene
  JOURNAL   Mol Cell Biol 9 (7), 3058-3072 (1989)
   PUBMED   2674679
REFERENCE   9  (residues 1 to 1094)
  AUTHORS   Fujii,H. and Shimada,T.
  TITLE     Isolation and characterization of cDNA clones derived from the
            divergently transcribed gene in the region upstream from the human
            dihydrofolate reductase gene
  JOURNAL   J Biol Chem 264 (17), 10057-10064 (1989)
   PUBMED   2722860
REFERENCE   10 (residues 1 to 1094)
  AUTHORS   McGrogan,M., Simonsen,C.C., Smouse,D.T., Farnham,P.J. and
            Schimke,R.T.
  TITLE     Heterogeneity at the 5' termini of mouse dihydrofolate reductase
            mRNAs. Evidence for multiple promoter regions
  JOURNAL   J Biol Chem 260 (4), 2307-2314 (1985)
   PUBMED   2982814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161588.2 and AC155263.2.
            
            On Jul 24, 2015 this sequence version replaced XP_006517604.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80360.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.63 cM"
     Protein         1..1094
                     /product="DNA mismatch repair protein Msh3 isoform 2"
                     /note="DNA mismatch repair protein Msh3; protein repair-1;
                     protein repair-3"
                     /calculated_mol_wt=123146
     Region          1..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P13705.3)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P20585; propagated from
                     UniProtKB/Swiss-Prot (P13705.3)"
     Region          183..1051
                     /region_name="MutS"
                     /note="DNA mismatch repair ATPase MutS [Replication,
                     recombination and repair]; COG0249"
                     /db_xref="CDD:440019"
     CDS             1..1094
                     /gene="Msh3"
                     /gene_synonym="D13Em1; REP-1; Rep-3; Rep3"
                     /coded_by="NM_001311120.2:108..3392"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS79222.1"
                     /db_xref="GeneID:17686"
                     /db_xref="MGI:MGI:109519"
ORIGIN      
        1 mprgksasgg staagpgpgr qtvlsrffrs agslrssass tepaekvteg dsrkrslgng
       61 gptkkkarkv pekeeenisv aahhpeakkc lrprivlksl eklkefccds alpqnrvqte
      121 alrerlevlp rctdfeditl qraknavlse dsksqanqkd sqfgpcpevf qktsdckpfn
      181 krsksvytpl elqyldmkqq hkdavlcvec gykyrffged aeiaarelni ychldhnfmt
      241 asipthrlfv hvrrlvakgy kvgvvkqtet aalkaigdnk ssvfsrklta lytkstlige
      301 dvnplirldd svnidevmtd tstnyllciy eekenikdkk kgnlsvgivg vqpatgevvf
      361 dcfqdsasrl eletrisslq pvelllpsdl svptemliqr atnvsvrddr irvermnnty
      421 feyshafqtv tefyareivd sqgsqslsgv inlekpvica laavirylke fnlekmlskp
      481 esfkqlssgm efmringttl rnleilqnqt dmktkgsllw vldhtktsfg rrklknwvtq
      541 pllklreina rldavsdvlh sessvfeqie nllrklpdve rglcsiyhkk cstqeffliv
      601 kslcqlksel qalmpavnsh vqsdllrali veapellspv ehylkvlngp aakvgdktel
      661 fkdlsdfpli kkrkneiqev ihsiqmrlqe frkilklpsl qyvtvsgqef mieiknsavs
      721 cipadwvkvg stkavsrfhp pfivesyrrl nqlreqlvld cnaewlgfle nfgehyhtlc
      781 kavdhlatvd cifslakvak qgnycrptlq eekkiiikng rhpmidvllg eqdqfvpnst
      841 slsdservmi itgpnmggks syikqvalvt imaqigsyvp aeeatigivd giftrmgaad
      901 niykgrstfm eeltdtaeii rraspqslvi ldelgrgtst hdgiaiayat leyfirdvks
      961 ltlfvthypp vcelekcype qvgnyhmgfl vnedeskqds gdmeqmpdsv tflyqitrgi
     1021 aarsyglnva kladvprevl qkaahkskel eglvslrrkr lecftdlwtt hsvkdlhtwa
     1081 dklemeeiqt slph
//
LOCUS       NP_001409027             295 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1A adrenergic receptor isoform 3 [Mus musculus].
ACCESSION   NP_001409027 XP_017171291
VERSION     NP_001409027.1
DBSOURCE    REFSEQ: accession NM_001422098.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 295)
  AUTHORS   Gural,B., Kirkland,L., Hockett,A., Sandroni,P., Zhang,J.,
            Rosa-Garrido,M., Swift,S.K., Chapski,D.J., Flinn,M.A.,
            O'Meara,C.C., Vondriska,T.M., Patterson,M., Jensen,B.C. and
            Rau,C.D.
  TITLE     Novel insights into post-myocardial infarction cardiac remodeling
            through algorithmic detection of cell-type composition shifts
  JOURNAL   PLoS Genet 21 (7), e1011807 (2025)
   PUBMED   40705823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 295)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 295)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   4  (residues 1 to 295)
  AUTHORS   Docherty,J.R.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (residues 1 to 295)
  AUTHORS   Lin,F., Owens,W.A., Chen,S., Stevens,M.E., Kesteven,S.,
            Arthur,J.F., Woodcock,E.A., Feneley,M.P. and Graham,R.M.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (residues 1 to 295)
  AUTHORS   O'Connell,T.D., Rokosh,D.G. and Simpson,P.C.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (residues 1 to 295)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (residues 1 to 295)
  AUTHORS   Xiao,L., Scofield,M.A. and Jeffries,W.B.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (residues 1 to 295)
  AUTHORS   Rockman,H.A., Koch,W.J. and Lefkowitz,R.J.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (residues 1 to 295)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129570.10 and AC154693.2.
            
            On Jun 1, 2023 this sequence version replaced XP_017171291.1.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.73396.1,
                                           SRR1660817.84951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     Protein         1..295
                     /product="alpha-1A adrenergic receptor isoform 3"
                     /note="alpha-1A adrenergic receptor; alpha-1A
                     adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic
                     receptor"
                     /calculated_mol_wt=32332
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Region          27..294
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Site            28..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          29..53
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          62..84
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            65..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          100..122
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            100..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            144..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          145..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          182..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            182..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          271..293
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..295
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /coded_by="NM_001422098.1:889..1776"
                     /note="isoform 3 is encoded by transcript variant 10"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
ORIGIN      
        1 mvllsenase gsncthppaq vniskaillg vilggliifg vlgnilvils vachrhlhsv
       61 thyyivnlav adllltstvl pfsaifeilg ywafgrvfcn iwaavdvlcc tasimglcii
      121 sidryigvsy plryptivtq rrgvrallcv walslvisig plfgwrqqap edeticqine
      181 epgyvlfsal gsfyvpltii lvmycrvyvv akresrglks glktdksdse qvtlrihrkn
      241 vpaegsgvss aknkthfsvr llkfsrekka aktlgivvgc fvlcwlpffl vmpia
//
LOCUS       NP_780749                297 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 27 [Mus
            musculus].
ACCESSION   NP_780749
VERSION     NP_780749.3
DBSOURCE    REFSEQ: accession NM_175540.6
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 297)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 297)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 297)
  AUTHORS   Guan,Z.H., Yang,D., Wang,Y., Ma,J.B. and Wang,G.N.
  TITLE     Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial
            ischemia/reperfusion injury through inhibiting the activation of
            the NF-kappaB signaling pathway
  JOURNAL   Exp Anim 73 (4), 376-389 (2024)
   PUBMED   38797667
  REMARK    GeneRIF: Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates
            myocardial ischemia/reperfusion injury through inhibiting the
            activation of the NF-kappaB signaling pathway.
REFERENCE   4  (residues 1 to 297)
  AUTHORS   Agca,S. and Kir,S.
  TITLE     EDA2R-NIK signaling in cancer cachexia
  JOURNAL   Curr Opin Support Palliat Care 18 (3), 126-131 (2024)
   PUBMED   38801457
  REMARK    GeneRIF: EDA2R-NIK signaling in cancer cachexia.
            Review article
REFERENCE   5  (residues 1 to 297)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   6  (residues 1 to 297)
  AUTHORS   Newton,K., French,D.M., Yan,M., Frantz,G.D. and Dixit,V.M.
  TITLE     Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR
            deficiency
  JOURNAL   Mol Cell Biol 24 (4), 1608-1613 (2004)
   PUBMED   14749376
  REMARK    GeneRIF: EDA-A2 transgenic mice exhibited multifocal
            myodegeneration; this phenotype was not observed in the absence of
            XEDAR
REFERENCE   7  (residues 1 to 297)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (residues 1 to 297)
  AUTHORS   Ruiz,S., Segrelles,C., Bravo,A., Santos,M., Perez,P., Leis,H.,
            Jorcano,J.L. and Paramio,J.M.
  TITLE     Abnormal epidermal differentiation and impaired
            epithelial-mesenchymal tissue interactions in mice lacking the
            retinoblastoma relatives p107 and p130
  JOURNAL   Development 130 (11), 2341-2353 (2003)
   PUBMED   12702649
REFERENCE   9  (residues 1 to 297)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 297)
  AUTHORS   Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
            Nishikawa,S. and Inoue,J.
  TITLE     TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
   PUBMED   12060722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732487.10.
            
            On May 30, 2009 this sequence version replaced NP_780749.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034909.1, SRR11927936.2774581.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.74 cM"
     Protein         1..297
                     /product="tumor necrosis factor receptor superfamily
                     member 27"
                     /note="X linked ectodysplasin receptor; EDA-A2 receptor;
                     X-linked ectodysplasin-A2 receptor"
                     /calculated_mol_wt=32935
     Region          2..41
                     /region_name="TNFR-Cys 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          3..118
                     /region_name="TNFRSF27"
                     /note="Tumor necrosis factor receptor superfamily member
                     27 (TNFRSF27), also known as ectodysplasin A2 receptor
                     (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR);
                     cd15838"
                     /db_xref="CDD:276934"
     Region          3..41
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276934"
     Region          43..83
                     /region_name="TNFR-Cys 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          44..83
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276934"
     Site            74
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BX35.1)"
     Site            77
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          85..118
                     /region_name="TNFR-Cys 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          86..118
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276934"
     Site            139..159
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     CDS             1..297
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /coded_by="NM_175540.6:189..1082"
                     /db_xref="CCDS:CCDS30293.1"
                     /db_xref="GeneID:245527"
                     /db_xref="MGI:MGI:2442860"
ORIGIN      
        1 mdcqeneyrd qwgrcvtcqq cgpgqelskd cgygeggdah civcpprkyk stwghhrcqt
       61 citcavinrv qkanctntsn aicgdclprf yrktrigglq dqecipctkq tpssevqctf
      121 qlslvkvdah tvppreatlv alvgsllvvf alaflglffl yckqifnrhc qcrdslqyea
      181 ektveedslf pvppgqetsp efpanegile ikplnsildd dcsstrgfpt qesftmasca
      241 seshsqwvht piecteldlq kfsssipstg petlrentae hsgdrlelyv pfevpsl
//
LOCUS       NP_001404113             501 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor RelB isoform 3 [Mus musculus].
ACCESSION   NP_001404113
VERSION     NP_001404113.1
DBSOURCE    REFSEQ: accession NM_001417184.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Geiselhoringer,A.L., Kolland,D., Patt,A.J., Hammann,L., Kohler,A.,
            Kreft,L., Wichmann,N., Hils,M., Ruedl,C., Riemann,M.,
            Biedermann,T., Anz,D., Diefenbach,A., Voehringer,D.,
            Schmidt-Weber,C.B., Straub,T., Pasztoi,M. and Ohnmacht,C.
  TITLE     Dominant immune tolerance in the intestinal tract imposed by
            RelB-dependent migratory dendritic cells regulates protective type
            2 immunity
  JOURNAL   Nat Commun 15 (1), 9143 (2024)
   PUBMED   39443450
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Deka,A., Kumar,N., Basu,S., Chawla,M., Bhattacharya,N., Ali,S.A.,
            Bhawna, Madan,U., Kumar,S., Das,B., Sengupta,D., Awasthi,A. and
            Basak,S.
  TITLE     Non-canonical NF-kappaB signaling limits the tolerogenic
            beta-catenin-Raldh2 axis in gut dendritic cells to exacerbate
            intestinal pathologies
  JOURNAL   EMBO J 43 (18), 3895-3915 (2024)
   PUBMED   39060515
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Lin,Y., Liu,M., Deng,P. and Zhang,J.
  TITLE     TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization
  JOURNAL   Cell Signal 120, 111210 (2024)
   PUBMED   38705503
  REMARK    GeneRIF: TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization.
            Erratum:[Cell Signal. 2024 Dec;124:111367. doi:
            10.1016/j.cellsig.2024.111367. PMID: 39214841]
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   5  (residues 1 to 501)
  AUTHORS   Zheng,C., Liu,L., Liu,C., Chu,F., Lang,Y., Liu,S., Mi,Y., Zhu,J.
            and Jin,T.
  TITLE     Alleviation of experimental autoimmune encephalomyelitis by
            transferring low RelB expression tolerogenic dendritic cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166934 (2024)
   PUBMED   37931715
  REMARK    GeneRIF: Alleviation of experimental autoimmune encephalomyelitis
            by transferring low RelB expression tolerogenic dendritic cells.
REFERENCE   6  (residues 1 to 501)
  AUTHORS   Burkly,L., Hession,C., Ogata,L., Reilly,C., Marconi,L.A., Olson,D.,
            Tizard,R., Cate,R. and Lo,D.
  TITLE     Expression of relB is required for the development of thymic
            medulla and dendritic cells
  JOURNAL   Nature 373 (6514), 531-536 (1995)
   PUBMED   7845467
REFERENCE   7  (residues 1 to 501)
  AUTHORS   Weih,F., Carrasco,D., Durham,S.K., Barton,D.S., Rizzo,C.A.,
            Ryseck,R.P., Lira,S.A. and Bravo,R.
  TITLE     Multiorgan inflammation and hematopoietic abnormalities in mice
            with a targeted disruption of RelB, a member of the NF-kappa B/Rel
            family
  JOURNAL   Cell 80 (2), 331-340 (1995)
   PUBMED   7834753
REFERENCE   8  (residues 1 to 501)
  AUTHORS   Egwuagu,C.E., Sztein,J., Chan,C.C., Mahdi,R., Nussenblatt,R.B. and
            Chepelinsky,A.B.
  TITLE     gamma Interferon expression disrupts lens and retinal
            differentiation in transgenic mice
  JOURNAL   Dev Biol 166 (2), 557-568 (1994)
   PUBMED   7813776
REFERENCE   9  (residues 1 to 501)
  AUTHORS   Lo,D., Quill,H., Burkly,L., Scott,B., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     A recessive defect in lymphocyte or granulocyte function caused by
            an integrated transgene
  JOURNAL   Am J Pathol 141 (5), 1237-1246 (1992)
   PUBMED   1443055
REFERENCE   10 (residues 1 to 501)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.58163.1,
                                           SRR7345562.1663380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.93 cM"
     Protein         1..501
                     /product="transcription factor RelB isoform 3"
                     /note="transcription factor relB"
                     /calculated_mol_wt=54078
     Region          46..217
                     /region_name="RHD-n_RelB"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of the reticuloendotheliosis viral oncogene homolog
                     B (RelB) protein; cd07886"
                     /db_xref="CDD:143646"
     Site            order(60,62..63,65..66,68,70,72,152..154)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143646"
     Region          225..321
                     /region_name="RHD_dimer"
                     /note="Rel homology dimerization domain; pfam16179"
                     /db_xref="CDD:465045"
     Region          324..501
                     /region_name="RelB_transactiv"
                     /note="RelB transactivation domain; pfam16181"
                     /db_xref="CDD:406565"
     CDS             1..501
                     /gene="Relb"
                     /gene_synonym="shep"
                     /coded_by="NM_001417184.1:2613..4118"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
ORIGIN      
        1 mprlvprgpa slssvtlgpa appppatpsw sctlgrlvsp gpcprpylvi teqpkqrgmr
       61 fryecegrsa gsilgesste asktlpaiel rdcgglreve vtaclvwkdw phrvhphslv
      121 gkdctdgvcr vrlrphvspr hsfnnlgiqc vrkkeieaai erkiqlgidp ynagslknhq
      181 evdmnvvric fqasyrdqqg hlhrmdpils epvydkkstn tselricrin kesgpctgge
      241 elyllcdkvq kedisvvfst aswegradfs qadvhrqiai vfktppyedl eisepvtvnv
      301 flqrltdgvc seplpftylp rdhdsygvdk krkrglpdvl gelsssdphg ieskrrkkkp
      361 vfldhflpgh ssglflppsa lqpadsdffp asislpglep pggpdllddg faydpsaptl
      421 ftmldllppa pplasavvgs ggagatvves sgpeplslds faapgpgdvg taslvgsnmf
      481 pnqyreaafg ggllspgpea t
//
LOCUS       NP_001396828             147 aa            linear   ROD 27-AUG-2025
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001396828 XP_006523566
VERSION     NP_001396828.1
DBSOURCE    REFSEQ: accession NM_001409899.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Demenego,G., Mancinelli,S., Borreca,A., Proce,R.O., Aragona,V.,
            Miotto,M., Cremonesi,M., Zucchelli,L., Corradini,I., Kim,E.,
            Ilic,K., Fraviga,E., Pellegrino,L., Badolato,R., Rusconi,R.,
            Pozzi,D., Kallikourdis,M., Cash,D., Matteoli,M. and Lodato,S.
  TITLE     Neurodevelopmental origins of structural and psychomotor defects in
            CXCR4-linked primary immunodeficiency
  JOURNAL   Neuron 113 (16), 2636-2655 (2025)
   PUBMED   40482638
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Hohsfield,L.A., Kim,S.J., Barahona,R.A., Henningfield,C.M.,
            Mansour,K., Vallejo,K.D., Tsourmas,K.I., Kwang,N.E., Ghorbanian,Y.,
            Angulo,J.A.A., Gao,P., Pachow,C., Inlay,M.A., Walsh,C.M., Xu,X.,
            Lane,T.E. and Green,K.N.
  TITLE     Identification of the velum interpositum as a meningeal-CNS route
            for myeloid cell trafficking into the brain
  JOURNAL   Neuron 113 (15), 2455-2473 (2025)
   PUBMED   40466634
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Guo,M., Liu,L., Mao,X., Xiao,M., He,X., Pan,X., Chen,Y., Yi,W.,
            Li,Q., Piao,X., Wang,H., Du,Y. and Cheng,Y.
  TITLE     Deciphering the role of CAPZA2 in neurodevelopmental disorders:
            insights from mouse models
  JOURNAL   Commun Biol 8 (1), 1048 (2025)
   PUBMED   40659881
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki,Y., Ohsawa,K., Kanazawa,H., Kohsaka,S. and Imai,Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa,K., Imai,Y., Kanazawa,H., Sasaki,Y. and Kohsaka,S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund,T., Shaikh,S., Kendall,E., Campbell,R.D., Hattori,M.,
            Makino,S. and Cooke,A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Jul 25, 2022 this sequence version replaced XP_006523566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.277632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001409899.1:386..829"
                     /note="isoform a is encoded by transcript variant 4"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_001277353             589 aa            linear   ROD 27-AUG-2025
DEFINITION  fragile X messenger ribonucleoprotein 1 isoform 2 [Mus musculus].
ACCESSION   NP_001277353 XP_006527875
VERSION     NP_001277353.1
DBSOURCE    REFSEQ: accession NM_001290424.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 589)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 589)
  AUTHORS   Wang,Z.H., Xu,C., Ma,Y.Y., Xue,W.X., Wang,H.Y., Fan,L.Y.,
            Zhang,C.Y., Li,L., Zhang,X.Y., Zhu,J.N. and Zhang,Q.P.
  TITLE     Oxytocin Improves Autistic Behaviors by Positively Shifting GABA
            Reversal Potential via NKCC1 in Early-Postnatal-Stage
  JOURNAL   Adv Sci (Weinh) 12 (21), e2415432 (2025)
   PUBMED   40305761
REFERENCE   3  (residues 1 to 589)
  AUTHORS   Jing,P.B., Zhou,Y.W., Zhang,F.M., Ge,J.Y., Wu,J.N., Xu,J.H.,
            Cao,X.H., Chang,N., Zhou,X., Luo,L. and Liu,X.J.
  TITLE     Autistic-like behaviors and impaired chronic inflammatory pain in
            primary nociceptive neuron-specific deletion of Mecp2 or Fmr1
            knockout male mice
  JOURNAL   Behav Brain Res 486, 115570 (2025)
   PUBMED   40174753
REFERENCE   4  (residues 1 to 589)
  AUTHORS   Lee,Y., Ishikawa,T., Lee,H., Lee,B., Ryu,C., Davila Mejia,I.,
            Kim,M., Lu,G., Hong,Y., Feng,M., Shin,H., Meloche,S.,
            Locksley,R.M., Koltsova,E., Grivennikov,S.I., Heiman,M., Choi,G.B.
            and Huh,J.R.
  TITLE     Brain-wide mapping of immune receptors uncovers a neuromodulatory
            role of IL-17E and the receptor IL-17RB
  JOURNAL   Cell 188 (8), 2203-2217 (2025)
   PUBMED   40199322
REFERENCE   5  (residues 1 to 589)
  AUTHORS   Hooshmandi,M., Ho-Tieng,D., Lister,K.C., Cai,W., Wong,C., Brown,N.,
            Fan,J., Hovhannisyan,V., Uttam,S., Prager-Khoutorsky,M.,
            Sonenberg,N., Gkogkas,C.G. and Khoutorsky,A.
  TITLE     Postnatal downregulation of Fmr1 in microglia promotes microglial
            reactivity and causes behavioural alterations in female mice
  JOURNAL   Mol Autism 16 (1), 17 (2025)
   PUBMED   40055803
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 589)
  AUTHORS   Verheij,C., de Graaff,E., Bakker,C.E., Willemsen,R., Willems,P.J.,
            Meijer,N., Galjaard,H., Reuser,A.J., Oostra,B.A. and Hoogeveen,A.T.
  TITLE     Characterization of FMR1 proteins isolated from different tissues
  JOURNAL   Hum Mol Genet 4 (5), 895-901 (1995)
   PUBMED   7633450
REFERENCE   7  (residues 1 to 589)
  AUTHORS   Khandjian,E.W., Fortin,A., Thibodeau,A., Tremblay,S., Cote,F.,
            Devys,D., Mandel,J.L. and Rousseau,F.
  TITLE     A heterogeneous set of FMR1 proteins is widely distributed in mouse
            tissues and is modulated in cell culture
  JOURNAL   Hum Mol Genet 4 (5), 783-789 (1995)
   PUBMED   7633436
REFERENCE   8  (residues 1 to 589)
  AUTHORS   Laval,S.H., Blair,H.J., Hirst,M.C., Davies,K.E. and Boyd,Y.
  TITLE     Mapping of FMR1, the gene implicated in fragile X-linked mental
            retardation, on the mouse X chromosome
  JOURNAL   Genomics 12 (4), 818-821 (1992)
   PUBMED   1572655
REFERENCE   9  (residues 1 to 589)
  AUTHORS   Faust,C.J., Verkerk,A.J., Wilson,P.J., Morris,C.P., Hopwood,J.J.,
            Oostra,B.A. and Herman,G.E.
  TITLE     Genetic mapping on the mouse X chromosome of human cDNA clones for
            the fragile X and Hunter syndromes
  JOURNAL   Genomics 12 (4), 814-817 (1992)
   PUBMED   1572654
REFERENCE   10 (residues 1 to 589)
  AUTHORS   Mandel,J.L., Arveiler,B., Camerino,G., Hanauer,A., Heilig,R.,
            Koenig,M. and Oberle,I.
  TITLE     Genetic mapping of the human X chromosome: linkage analysis of the
            q26-q28 region that includes the fragile X locus and isolation of
            expressed sequences
  JOURNAL   Cold Spring Harb Symp Quant Biol 51 Pt 1, 195-203 (1986)
   PUBMED   3472716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055766.31.
            
            On Mar 12, 2014 this sequence version replaced XP_006527875.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.931990.1,
                                           SRR14777535.2962538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 34.83 cM"
     Protein         1..589
                     /product="fragile X messenger ribonucleoprotein 1 isoform
                     2"
                     /note="FMRP translational regulator 1; synaptic functional
                     regulator FMR1"
                     /calculated_mol_wt=66039
     Region          1..55
                     /region_name="Tudor_Agenet_FMR1_rpt1"
                     /note="first Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20471"
                     /db_xref="CDD:410542"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410542"
     Region          58..120
                     /region_name="Tudor_Agenet_FMR1_rpt2"
                     /note="second Tudor-like Agenet domain found in synaptic
                     functional regulator FMR1 and similar proteins; cd20474"
                     /db_xref="CDD:410545"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410545"
     Region          123..199
                     /region_name="KH_I_FMR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22506"
                     /db_xref="CDD:411934"
     Region          218..280
                     /region_name="KH_I_FMR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation protein 1 (FMR1) and
                     similar proteins; cd22509"
                     /db_xref="CDD:411937"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411937"
     Region          281..423
                     /region_name="KH-I"
                     /note="K homology (KH) RNA-binding domain, type I;
                     cl00098"
                     /db_xref="CDD:469614"
     Region          419..>490
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:463501"
     Region          524..589
                     /region_name="FXMR_C2"
                     /note="Fragile X-related mental retardation protein
                     C-terminal region 2; pfam16098"
                     /db_xref="CDD:465020"
     CDS             1..589
                     /gene="Fmr1"
                     /gene_synonym="Fmr-1; FMRP"
                     /coded_by="NM_001290424.2:236..2005"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS72385.1"
                     /db_xref="GeneID:14265"
                     /db_xref="MGI:MGI:95564"
ORIGIN      
        1 meelvvevrg sngafykafv kdvhedsitv afennwqper qipfhdvrfp ppvgynkdin
       61 esdevevysr anekepccww lakvrmikge fyvieyaacd atyneivtie rlrsvnpnkp
      121 atkdtfhkik levpedlrqm cakesahkdf kkavgafsvt ydpenyqlvi lsinevtskr
      181 ahmlidmhfr slrtklslil rneeaskqle ssrqlasrfh eqfivredlm glaigthgan
      241 iqqarkvpgv taidldedtc tfhiygedqd avkkarsfle faedviqvpr nlvgkvigkn
      301 gkliqeivdk sgvvrvriea eneksvpqee eimppsslps nnsrvgpnss eekkhldtke
      361 nthfsqpnst kvqrvlvvss ivaggpqkpe pkawqgmvpf vfvgtkdsia natvlldyhl
      421 nylkevdqlr lerlqideql rqigassrpp pnrtdkekgy vtddgqgmgr gsrpyrnrgh
      481 grrgpgytsa pteeeresfl rrgdgrrrgg ggrgqggrgr gggfkgnddh srtdnrprnp
      541 reakgrtadg slqsassegs rlrtgkdrnq kkekpdsvdg lqplvngvp
//
LOCUS       NP_001229278             956 aa            linear   ROD 27-AUG-2025
DEFINITION  anoctamin-1 isoform 2 [Mus musculus].
ACCESSION   NP_001229278
VERSION     NP_001229278.2
DBSOURCE    REFSEQ: accession NM_001242349.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 956)
  AUTHORS   Chakraborty,S., Wenzlitschke,N., Anderson,M.J., Eraso,A.,
            Baudic,M., Thompson,J.J., Evans,A.A., Shatford-Adams,L.M.,
            Chari,R., Awasthi,P., Dale,R.K., Lewandoski,M., Petros,T.J. and
            Rocha,P.P.
  TITLE     Deletion of a single CTCF motif at the boundary of a chromatin
            domain with three FGF genes disrupts gene expression and embryonic
            development
  JOURNAL   Dev Cell 60 (13), 1838-1853 (2025)
   PUBMED   40015278
REFERENCE   2  (residues 1 to 956)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   3  (residues 1 to 956)
  AUTHORS   Penrod,S., Tang,X., Moon,C., Whitsett,J.A., Naren,A.P. and Huang,Y.
  TITLE     EMC3 is critical for CFTR function and calcium mobilization in the
            mouse intestinal epithelium
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 328 (1), G72-G82 (2025)
   PUBMED   39641142
REFERENCE   4  (residues 1 to 956)
  AUTHORS   Sun,Z., Shan,X., Fan,C., Liu,L., Li,S., Wang,J., Zhou,N., Zhu,M.
            and Chen,H.
  TITLE     TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity
  JOURNAL   Stem Cells 42 (10), 902-913 (2024)
   PUBMED   39097775
  REMARK    GeneRIF: TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity.
REFERENCE   5  (residues 1 to 956)
  AUTHORS   Raghavan,S., Brishti,M.A., Bernardelli,A., Mata-Daboin,A.,
            Jaggar,J.H. and Leo,M.D.
  TITLE     Extracellular glucose and dysfunctional insulin receptor signaling
            independently upregulate arterial smooth muscle TMEM16A expression
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1237-C1247 (2024)
   PUBMED   38581667
  REMARK    GeneRIF: Extracellular glucose and dysfunctional insulin receptor
            signaling independently upregulate arterial smooth muscle TMEM16A
            expression.
REFERENCE   6  (residues 1 to 956)
  AUTHORS   Yang,Y.D., Cho,H., Koo,J.Y., Tak,M.H., Cho,Y., Shim,W.S.,
            Park,S.P., Lee,J., Lee,B., Kim,B.M., Raouf,R., Shin,Y.K. and Oh,U.
  TITLE     TMEM16A confers receptor-activated calcium-dependent chloride
            conductance
  JOURNAL   Nature 455 (7217), 1210-1215 (2008)
   PUBMED   18724360
  REMARK    GeneRIF: transmembrane protein 16A (TMEM16A, which we also call
            anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride
            channel that is activated by intracellular Ca(2+) and
            Ca(2+)-mobilizing stimuli
REFERENCE   7  (residues 1 to 956)
  AUTHORS   Rock,J.R., Futtner,C.R. and Harfe,B.D.
  TITLE     The transmembrane protein TMEM16A is required for normal
            development of the murine trachea
  JOURNAL   Dev Biol 321 (1), 141-149 (2008)
   PUBMED   18585372
  REMARK    GeneRIF: Study reports that all mice homozygous for a null allele
            of Tmem16a died within one month of birth and exhibited severe
            tracheomalacia with gaps in the tracheal cartilage rings along the
            entire length of the trachea.
REFERENCE   8  (residues 1 to 956)
  AUTHORS   Rock,J.R., Lopez,M.C., Baker,H.V. and Harfe,B.D.
  TITLE     Identification of genes expressed in the mouse limb using a novel
            ZPA microarray approach
  JOURNAL   Gene Expr Patterns 8 (1), 19-26 (2007)
   PUBMED   17911046
REFERENCE   9  (residues 1 to 956)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   10 (residues 1 to 956)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122336.4 and AC153792.4.
            
            On Dec 11, 2019 this sequence version replaced NP_001229278.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062959.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.85 cM"
     Protein         1..956
                     /product="anoctamin-1 isoform 2"
                     /note="transmembrane protein 16A; anoctamin-1"
                     /calculated_mol_wt=110358
     Region          54..317
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          92..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5XXA6; propagated from
                     UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Region          320..896
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     Site            334..354
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            407..427
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            428
                     /site_type="other"
                     /note="Unlikely to bind calcium but may play an important
                     structural role. /evidence=ECO:0000269|PubMed:33378669;
                     propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            490..510
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            539..559
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            578..598
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            628..648
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            696..716
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            717..737
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            755..775
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            802
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            863..883
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Region          924..956
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     CDS             1..956
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /coded_by="NM_001242349.2:253..3123"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57600.1"
                     /db_xref="GeneID:101772"
                     /db_xref="MGI:MGI:2142149"
ORIGIN      
        1 mrvpekystl paedrsvhiv nicaiedlgy lpsegtllns lsvdpdaeck yglyfrdgkr
       61 kvdyilvyhh krasgsrtla rrglqndmvl gtrsvrqdqp lpgkgspvda gspevpmdyh
      121 eddkrfrree yegnlleagl elendedtki hgvgfvkiha pwhvlcreae flklkmptkk
      181 vyhisetrgl lktinsvlqk itdpiqpkva ehrpqttkrl sypfsrekqh lfdltdrdsf
      241 fdsktrstiv yeilkrttct kakysmgits llangvysaa yplhdgdyeg dnvefndrkl
      301 lyeewasygv fykyqpidlv rkyfgekvgl yfawlgaytq mlipasivgv ivflygcatv
      361 denipsmemc dqrynitmcp lcdktcsywk mssacatara shlfdnpatv ffsvfmalwa
      421 atfmehwkrk qmrlnyrwdl tgfeeeedhp raeyearvle kslrkesrnk etdkvkltwr
      481 drfpayftnl vsiifmiavt faivlgviiy ristaaalam nsspsvrsni rvtvtatavi
      541 inlvviilld evygciarwl tkievpktek sfeerltfka fllkfvnsyt pifyvaffkg
      601 rfvgrpgdyv yifrsfrmee capggclmel ciqlsiimlg kqliqnnlfe igipkmkkfi
      661 rylklrrqsp sdreeyvkrk qryevdfnle pfagltpeym emiiqfgfvt lfvasfplap
      721 lfallnniie irldakkfvt elrrpvaira kdigiwynil rgvgklavii nafvisftsd
      781 fiprlvylym ysqngtmhgf vnhtlssfnv sdfqngtapn dpldlgyevq icrykdyrep
      841 pwsehkydis kdfwavlaar lafvivfqnl vmfmsdfvdw vipdipkdis qqihkekvlm
      901 velfmreeqg kqqlldtwme kekprdvpcn nhsptthpea gdgspvpsye yhgdal
//
LOCUS       NP_001408083             366 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform e [Mus musculus].
ACCESSION   NP_001408083 XP_030109117
VERSION     NP_001408083.1
DBSOURCE    REFSEQ: accession NM_001421154.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109117.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1452855.1,
                                           SRR17784649.379681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..366
                     /product="ELAV-like protein 4 isoform e"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40245
     Region          43..365
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..366
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421154.1:297..1397"
                     /note="isoform e is encoded by transcript variant 10"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 meqiistmep qvsngptsnt sngpssnnrn cpspmqtgaa tddsktnliv nylpqnmtqe
       61 efrslfgsig eiescklvrd kitgqslgyg fvnyidpkda ekaintlngl rlqtktikvs
      121 yarpssasir danlyvsglp ktmtqkeleq lfsqygriit srilvdqvtg vsrgvgfirf
      181 dkrieaeeai kglngqkpsg atepitvkfa nnpsqkssqa llsqlyqspn rrypgplhhq
      241 aqrfrldnll nmaygvkrfs pitidgmtsl vgmnipghtg tgwcifvynl spdsdesvlw
      301 qlfgpfgavn nvkvirdfnt nkckgfgfvt mtnydeaama iaslngyrlg drvlqvsfkt
      361 nkahks
//
LOCUS       NP_001152865             304 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon regulatory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001152865
VERSION     NP_001152865.1
DBSOURCE    REFSEQ: accession NM_001159393.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Risley,C.A., Schultz,M.D., Allie,S.R., Liu,S., Peel,J.N.,
            Nellore,A., Fucile,C.F., Scharer,C.D., Boss,J.M., Randall,T.D.,
            Rosenberg,A.F. and Lund,F.E.
  TITLE     Transcription factor T-bet regulates the maintenance and
            differentiation potential of lymph node and lung effector memory B
            cell subsets
  JOURNAL   Immunity 58 (7), 1706-1724 (2025)
   PUBMED   40543512
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Sun,K., Lu,F., Hou,L., Zhang,X., Pan,C., Liu,H., Zheng,Z., Guo,Z.,
            Ruan,Z., Hou,Y., Zhang,J., Guo,F. and Zhu,W.
  TITLE     IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte
            damage in osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 366 (2024)
   PUBMED   39026271
  REMARK    GeneRIF: IRF1 regulation of ZBP1 links mitochondrial DNA and
            chondrocyte damage in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
  REMARK    GeneRIF: Opposing tumor-cell-intrinsic and -extrinsic roles of the
            IRF1 transcription factor in antitumor immunity.
REFERENCE   4  (residues 1 to 304)
  AUTHORS   Wang,Y., Shen,Y., Liang,J., Wang,S., Huang,Y., Zhu,Q., Zhang,X.,
            Yu,K., Tong,G., Yang,C., Li,Y., Wang,J. and Zhao,Y.
  TITLE     Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by
            CD8+ T cells in cerebral malaria
  JOURNAL   J Neuroinflammation 21 (1), 119 (2024)
   PUBMED   38715061
  REMARK    GeneRIF: Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate
            damage by CD8[+] T cells in cerebral malaria.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 304)
  AUTHORS   Loftus,S.N., Gharaee-Kermani,M., Xu,B., Moore,T.M., Hannoudi,A.,
            Mallbris,M.J., Klein,B., Gudjonsson,J.E. and Kahlenberg,J.M.
  TITLE     Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1
  JOURNAL   Front Immunol 15, 1384606 (2024)
   PUBMED   38660315
  REMARK    GeneRIF: Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 304)
  AUTHORS   Gribaudo,G., Caliendo,A., Lembo,D., Cavallo,R. and Landolfo,S.
  TITLE     Molecular cloning of interferon-gamma inducible genes from a murine
            pre-B cell leukemia
  JOURNAL   J Biol Regul Homeost Agents 6 (4), 137-141 (1992)
   PUBMED   1296455
REFERENCE   7  (residues 1 to 304)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (residues 1 to 304)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (residues 1 to 304)
  AUTHORS   Driggers,P.H., Ennist,D.L., Gleason,S.L., Mak,W.H., Marks,M.S.,
            Levi,B.Z., Flanagan,J.R., Appella,E. and Ozato,K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (residues 1 to 304)
  AUTHORS   Harada,H., Fujita,T., Miyamoto,M., Kimura,Y., Maruyama,M.,
            Furia,A., Miyata,T. and Taniguchi,T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266109.1 and AK152193.1.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (b) has a shorter and distinct C-terminus, compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152193.1, AK153514.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.0 cM"
     Protein         1..304
                     /product="interferon regulatory factor 1 isoform b"
                     /calculated_mol_wt=34496
     Region          7..112
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(40,80,82..83,86)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            78
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10914; propagated from
                     UniProtKB/Swiss-Prot (P15314.1)"
     Site            order(85..86,88,91)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          93..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15314.1)"
     CDS             1..304
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /coded_by="NM_001159393.1:270..1184"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS48796.1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
ORIGIN      
        1 mpitrmrmrp wlemqinsnq ipgliwinke emifqipwkh aakhgwdink daclfrswai
       61 htgrykagek epdpktwkan frcamnslpd ieevkdqsrn kgssavrvyr mlppltrnqr
      121 kerkskssrd tksktkrklc gdvspdtfsd glssstlpdd hssyttqgyl gqdldmerdi
      181 tpalspcvvs sslsewhmqm diipdsttdl ynlqvspmps tseaatdede egkiaedlmk
      241 lfeqsewqpt hidgkgylln epgtqlssvy gdfsckeepe idsprgnllm gvfcwlsawa
      301 saeh
//
LOCUS       NP_035025                383 aa            linear   ROD 27-AUG-2025
DEFINITION  neurogenic differentiation factor 2 [Mus musculus].
ACCESSION   NP_035025
VERSION     NP_035025.3
DBSOURCE    REFSEQ: accession NM_010895.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 383)
  AUTHORS   Demenego,G., Mancinelli,S., Borreca,A., Proce,R.O., Aragona,V.,
            Miotto,M., Cremonesi,M., Zucchelli,L., Corradini,I., Kim,E.,
            Ilic,K., Fraviga,E., Pellegrino,L., Badolato,R., Rusconi,R.,
            Pozzi,D., Kallikourdis,M., Cash,D., Matteoli,M. and Lodato,S.
  TITLE     Neurodevelopmental origins of structural and psychomotor defects in
            CXCR4-linked primary immunodeficiency
  JOURNAL   Neuron 113 (16), 2636-2655 (2025)
   PUBMED   40482638
REFERENCE   2  (residues 1 to 383)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 383)
  AUTHORS   Wu,J., Yu,H., Dou,X., Yin,B., Hou,L., Xue,Y., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     Posttranscriptional Control of Neural Progenitors Temporal Dynamics
            During Neocortical Development by Syncrip
  JOURNAL   Adv Sci (Weinh) 12 (8), e2411732 (2025)
   PUBMED   39776340
REFERENCE   4  (residues 1 to 383)
  AUTHORS   Pang,Y., Ruan,X., Liu,W., Hou,L., Yin,B., Shu,P. and Peng,X.
  TITLE     MicroRNA-495 Modulates Neuronal Layer Fate Determination by
            Targeting Tcf4
  JOURNAL   Int J Biol Sci 20 (15), 6207-6221 (2024)
   PUBMED   39664574
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 383)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 383)
  AUTHORS   Tamimi,R.M., Steingrimsson,E., Montgomery-Dyer,K., Copeland,N.G.,
            Jenkins,N.A. and Tapscott,S.J.
  TITLE     NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and
            5q23-q31 and mouse chromosomes 11 and 13, respectively
  JOURNAL   Genomics 40 (2), 355-357 (1997)
   PUBMED   9119405
REFERENCE   7  (residues 1 to 383)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   8  (residues 1 to 383)
  AUTHORS   Isaka,F., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     Genetic mapping of four mouse bHLH genes related to Drosophila
            proneural gene atonal
  JOURNAL   Genomics 37 (3), 400-402 (1996)
   PUBMED   8938455
REFERENCE   9  (residues 1 to 383)
  AUTHORS   McCormick,M.B., Tamimi,R.M., Snider,L., Asakura,A., Bergstrom,D.
            and Tapscott,S.J.
  TITLE     NeuroD2 and neuroD3: distinct expression patterns and
            transcriptional activation potentials within the neuroD gene family
  JOURNAL   Mol Cell Biol 16 (10), 5792-5800 (1996)
   PUBMED   8816493
REFERENCE   10 (residues 1 to 383)
  AUTHORS   Yasunami,M., Suzuki,K., Maruyama,H., Kawakami,H., Nagai,Y.,
            Hagiwara,M. and Ohkubo,H.
  TITLE     Molecular cloning and characterization of a cDNA encoding a novel
            basic helix-loop-helix protein structurally related to Neuro-D/BHF1
  JOURNAL   Biochem Biophys Res Commun 220 (3), 754-758 (1996)
   PUBMED   8607837
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158767.1, CJ237767.1, CJ063668.1, CJ237963.1 and CD741852.1.
            
            On Sep 14, 2007 this sequence version replaced NP_035025.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158767.1, BC058965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     Protein         1..383
                     /product="neurogenic differentiation factor 2"
                     /note="neuroD-related factor"
                     /calculated_mol_wt=41362
     Region          1..130
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62414.3)"
     Region          89..181
                     /region_name="bHLH_TS_NeuroD2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     neurogenic differentiation factor 2 (NeuroD2) and similar
                     proteins; cd19720"
                     /db_xref="CDD:381563"
     Region          108..114
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62414.3)"
     Site            order(128,131..132,134,136,139,159..160)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381563"
     Site            order(138,141..142,144..145,148..149,160..161,164,168,
                     170..171,174..175,177..178)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381563"
     Region          181..311
                     /region_name="Neuro_bHLH"
                     /note="Neuronal helix-loop-helix transcription factor;
                     pfam12533"
                     /db_xref="CDD:463621"
     CDS             1..383
                     /gene="Neurod2"
                     /gene_synonym="bHLHa1; Ndrf"
                     /coded_by="NM_010895.3:218..1369"
                     /db_xref="CCDS:CCDS25343.1"
                     /db_xref="GeneID:18013"
                     /db_xref="MGI:MGI:107755"
ORIGIN      
        1 mltrlfsepg llsdvpkfas wgdgdddepr sdkgdappqp ppapgsgapg paraakpvsl
       61 rggeeipept laevkeegel ggeeeeeeee eegldeaege rpkkrgpkkr kmtkarlers
      121 klrrqkanar ernrmhdlna aldnlrkvvp cysktqklsk ietlrlakny iwalseilrs
      181 gkrpdlvsyv qtlckglsqp ttnlvagclq lnsrnflteq gadgagrfhg sggpfamhpy
      241 pypcsrlaga qcqaagglgg gaahalrthg ycaayetlya aaggggaspd ynsseyegpl
      301 spplclngnf slkqdsspdh eksyhysmhy salpgsrptg hglvfgssav rggvhsenll
      361 sydmhlhhdr gpmyeelnaf fhn
//
LOCUS       NP_032713                420 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear factor 1 B-type isoform 3 [Mus musculus].
ACCESSION   NP_032713 NP_780762
VERSION     NP_032713.3
DBSOURCE    REFSEQ: accession NM_008687.7
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 420)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 420)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 420)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   4  (residues 1 to 420)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 420)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 420)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 420)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (residues 1 to 420)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   9  (residues 1 to 420)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   10 (residues 1 to 420)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592283.5, BX324149.4 and AL773518.3.
            
            On Jun 10, 2007 this sequence version replaced NP_032713.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084941.1, AK083167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.4 cM"
     Protein         1..420
                     /product="nuclear factor 1 B-type isoform 3"
                     /note="nuclear factor 1 B-type; nuclear factor 1/B;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /calculated_mol_wt=47341
     Region          10..47
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          69..173
                     /region_name="MH1"
                     /note="MH1 domain; pfam03165"
                     /db_xref="CDD:460833"
     Region          209..>415
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P97863.2)"
     Site            312
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            335
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            388
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Region          397..405
                     /region_name="9aaTAD.
                     /evidence=ECO:0000250|UniProtKB:O00712"
                     /note="propagated from UniProtKB/Swiss-Prot (P97863.2)"
     CDS             1..420
                     /gene="Nfib"
                     /gene_synonym="6720429L07Rik; CTF; E030026I10Rik; NF-I/B;
                     NF1-B; NFI-B"
                     /coded_by="NM_008687.7:620..1882"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS38790.1"
                     /db_xref="GeneID:18028"
                     /db_xref="MGI:MGI:103188"
ORIGIN      
        1 mmyspicltq defhpfieal lphvraiayt wfnlqarkrk yfkkhekrms kdeeravkde
       61 llsekpeikq kwasrllakl rkdirqeyre dfvltvtgkk hpccvlsnpd qkgkirridc
      121 lrqadkvwrl dlvmvilfkg iplestdger lmksphctnp alcvqphhit vsvkeldlfl
      181 ayyvqeqdsg qsgspshsdp aknppgyled sfvksgvfnv selvrvsrtp itqgtgvnfp
      241 igeipsqpyy hdmnsgvnlq rslssppssk rpktisiden mepsptgdfy pspnspaags
      301 rtwherdqdm sspttmkkpe kplfsstspq dssprlstfp qhhhpgipgv ahsvistrtp
      361 pppsplpfpt qailppapss yfshptiryp phlnpqdtlk nyvpsydpss pqtsqswylg
//
LOCUS       NP_001128572             235 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-34 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001128572
VERSION     NP_001128572.1
DBSOURCE    REFSEQ: accession NM_001135100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 235)
  AUTHORS   Van Hove,H., Gluck,C., Mildenberger,W., Petrova,E., Maheshwari,U.,
            Hane,P., Kreiner,V., Bijnen,M., Mussak,C., Utz,S.G., Droux,J.,
            Ingelfinger,F., Ashworth,C., Stifter,S.A., Roussel,E., Lelios,I.,
            Vermeer,M., Huang,S.F., Zhou,Q., Chen,Z., Calvet,C., Bourgeois,S.,
            Schaffenrath,J., Razansky,D., Juang,J.X., Asano,K., Pelczar,P.,
            Mundt,S., Weber,B., Wegener,S., Tugues,S., Stockmann,C., Becher,B.,
            Keller,A., El Amki,M. and Greter,M.
  TITLE     Interleukin-34-dependent perivascular macrophages promote vascular
            function in the brain
  JOURNAL   Immunity 58 (5), 1289-1305 (2025)
   PUBMED   40315842
REFERENCE   2  (residues 1 to 235)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   3  (residues 1 to 235)
  AUTHORS   Rayasam,A., Moe,A., Kudek,M., Shah,R.K., Yuan,C.Y., Miller,J.M.,
            Rau,M., Patton,M., Wanat,K., Colonna,M., Zamora,A.E. and
            Drobyski,W.R.
  TITLE     Intestinal epithelium-derived IL-34 reprograms macrophages to
            mitigate gastrointestinal tract graft-versus-host disease
  JOURNAL   Sci Transl Med 17 (785), eadn3963 (2025)
   PUBMED   39937882
REFERENCE   4  (residues 1 to 235)
  AUTHORS   Munoz-Garcia,J., Vargas-Franco,J.W., Schiavone,K., Keatinge,M.T.,
            Young,R., Amiaud,J., Fradet,L., Jegou,J.F., Yagita,H.,
            Blin-Wakkach,C., Wakkach,A., Cochonneau,D., Ollivier,E.,
            Pugiere,M., Henriquet,C., Legendre,M., Giurgea,I., Amselem,S.,
            Heymann,M.F., Teletchea,S., Lezot,F. and Heymann,D.
  TITLE     Interleukin-34 orchestrates bone formation through its binding to
            bone morphogenic proteins
  JOURNAL   Theranostics 15 (7), 3185-3202 (2025)
   PUBMED   40083929
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 235)
  AUTHORS   Nian,Z., Dou,Y., Shen,Y., Liu,J., Du,X., Jiang,Y., Zhou,Y., Fu,B.,
            Sun,R., Zheng,X., Tian,Z. and Wei,H.
  TITLE     Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation
  JOURNAL   Immunity 57 (10), 2344-2361 (2024)
   PUBMED   39321806
REFERENCE   6  (residues 1 to 235)
  AUTHORS   Chen,Z., Buki,K., Vaaraniemi,J., Gu,G. and Vaananen,H.K.
  TITLE     The critical role of IL-34 in osteoclastogenesis
  JOURNAL   PLoS One 6 (4), e18689 (2011)
   PUBMED   21494622
  REMARK    GeneRIF: This study was to explore the biological function,
            specifically osteoclastogenesis and bone metabolism, of il-34.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 235)
  AUTHORS   Chihara,T., Suzu,S., Hassan,R., Chutiwitoonchai,N., Hiyoshi,M.,
            Motoyoshi,K., Kimura,F. and Okada,S.
  TITLE     IL-34 and M-CSF share the receptor Fms but are not identical in
            biological activity and signal activation
  JOURNAL   Cell Death Differ 17 (12), 1917-1927 (2010)
   PUBMED   20489731
REFERENCE   8  (residues 1 to 235)
  AUTHORS   Wei,S., Nandi,S., Chitu,V., Yeung,Y.G., Yu,W., Huang,M.,
            Williams,L.T., Lin,H. and Stanley,E.R.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (residues 1 to 235)
  AUTHORS   Baud'huin,M., Renault,R., Charrier,C., Riet,A., Moreau,A.,
            Brion,R., Gouin,F., Duplomb,L. and Heymann,D.
  TITLE     Interleukin-34 is expressed by giant cell tumours of bone and plays
            a key role in RANKL-induced osteoclastogenesis
  JOURNAL   J Pathol 221 (1), 77-86 (2010)
   PUBMED   20191615
REFERENCE   10 (residues 1 to 235)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148512.1, AK008082.1 and AW743837.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016254.1, SRR7652917.590638.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.68 cM"
     Protein         1..235
                     /product="interleukin-34 isoform 1 precursor"
                     /calculated_mol_wt=24578
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2205
     mat_peptide     21..235
                     /product="Interleukin-34. /id=PRO_0000294349"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R1R4.1)"
                     /calculated_mol_wt=24578
     Region          28..184
                     /region_name="IL34"
                     /note="Interleukin 34; pfam15036"
                     /db_xref="CDD:434409"
     Site            100
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R1R4.1)"
     CDS             1..235
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /coded_by="NM_001135100.2:584..1291"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS52669.1"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
ORIGIN      
        1 mpwglawlyc lgilldvalg nenleiwtlt qdkecdltgy lrgklqyknr lqymkhyfpi
       61 nyriavpyeg vlrvanitrl qkahvserel rylwvlvsln atesvmdvll eghpswkylq
      121 evqtllenvq rslmdveigp hveavlslls tpglslklvr pkalldncfr vmellycscc
      181 kqspilkwqd celprlhphs pgslmqctat nvyplsrqtp tslpgspsss hgslp
//
LOCUS       NP_991338                187 aa            linear   ROD 27-AUG-2025
DEFINITION  corticoliberin preproprotein [Mus musculus].
ACCESSION   NP_991338 XP_357335
VERSION     NP_991338.1
DBSOURCE    REFSEQ: accession NM_205769.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 187)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 187)
  AUTHORS   Wiest,A., Maurer,J.J., Beier,K.T., Weber,F. and Chung,S.
  TITLE     Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress
            on Memory and Sleep
  JOURNAL   J Neurosci 45 (27), e2146242025 (2025)
   PUBMED   40490361
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 187)
  AUTHORS   Li,T., Zhou,W., Ke,J., Chen,M., Wang,Z., Hayashi,L., Su,X., Jia,W.,
            Huang,W., Wang,C.S., Bengyella,K., Yang,Y., Hernandez,R., Zhang,Y.,
            Song,X., Xu,T., Huang,T. and Liu,Y.
  TITLE     A pontine center in descending pain control
  JOURNAL   Neuron 113 (11), 1789-1804 (2025)
   PUBMED   40132590
REFERENCE   4  (residues 1 to 187)
  AUTHORS   Tretiakov,E.O., Hevesi,Z., Boroczky,C., Alpar,A., Harkany,T. and
            Keimpema,E.
  TITLE     Molecular Fingerprint of Endocannabinoid Signaling in the
            Developing Paraventricular Nucleus of the Hypothalamus as Revealed
            by Single-Cell RNA-Seq and In Situ Hybridization
  JOURNAL   Cells 14 (11), 788 (2025)
   PUBMED   40497964
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 187)
  AUTHORS   Liu,Y., Ng,L., Liu,C. and Forrest,D.
  TITLE     Serotonergic and Chemosensory Brain Areas and Sensory Ganglia
            Expressing Type 3 Deiodinase Mapped With Dio3Cre drivers
  JOURNAL   Endocrinology 166 (7) (2025)
   PUBMED   40302251
REFERENCE   6  (residues 1 to 187)
  AUTHORS   Im,E.
  TITLE     Corticotropin-releasing Hormone and Its Biological Diversity toward
            Angiogenesis
  JOURNAL   Intest Res 12 (2), 96-102 (2014)
   PUBMED   25349575
  REMARK    Review article
REFERENCE   7  (residues 1 to 187)
  AUTHORS   Keegan,C.E., Karolyi,I.J., Knapp,L.T., Bourbonais,F.J., Camper,S.A.
            and Seasholtz,A.F.
  TITLE     Expression of corticotropin-releasing hormone transgenes in neurons
            of adult and developing mice
  JOURNAL   Mol Cell Neurosci 5 (6), 505-514 (1994)
   PUBMED   7704423
REFERENCE   8  (residues 1 to 187)
  AUTHORS   Koob,G.F. and Bloom,F.E.
  TITLE     Corticotropin-releasing factor and behavior
  JOURNAL   Fed Proc 44 (1 Pt 2), 259-263 (1985)
   PUBMED   3871412
REFERENCE   9  (residues 1 to 187)
  AUTHORS   Brown,M.R. and Fisher,L.A.
  TITLE     Corticotropin-releasing factor: effects on the autonomic nervous
            system and visceral systems
  JOURNAL   Fed Proc 44 (1 Pt 2), 243-248 (1985)
   PUBMED   2981744
REFERENCE   10 (residues 1 to 187)
  AUTHORS   Vale,W., Spiess,J., Rivier,C. and Rivier,J.
  TITLE     Characterization of a 41-residue ovine hypothalamic peptide that
            stimulates secretion of corticotropin and beta-endorphin
  JOURNAL   Science 213 (4514), 1394-1397 (1981)
   PUBMED   6267699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ050024.1, BC116921.1 and
            BE993430.1.
            
            On Mar 22, 2004 this sequence version replaced XP_357335.1.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            factor family and preproprotein that is proteolytically processed
            to generate a mature protein product. This protein product is a
            neuropeptide hormone that binds to the corticotropin releasing
            hormone receptors (CRHR1 and CRHR2) to stimulate the release of
            adrenocorticotropic hormone from the pituitary gland in response to
            stress. The encoded protein may also regulate angiogenesis and
            inflammation. Homozygous knockout mice for this gene exhibit
            reduced corticosterone levels while the offspring of these mice die
            perinatally. [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO714297.1, CJ050024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.75 cM"
     Protein         1..187
                     /product="corticoliberin preproprotein"
                     /note="corticoliberin; corticotropin releasing factor"
                     /calculated_mol_wt=18762
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8CIT0.1)"
                     /calculated_mol_wt=2034
     Region          75..94
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIT0.1)"
     Region          114..146
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIT0.1)"
     mat_peptide     145..185
                     /product="Corticoliberin. /id=PRO_0000006215"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CIT0.1)"
                     /calculated_mol_wt=4759
     Region          148..185
                     /region_name="CRF"
                     /note="Corticotropin-releasing factor family; pfam00473"
                     /db_xref="CDD:425703"
     Site            185
                     /site_type="amidation"
                     /note="Isoleucine amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q8CIT0.1)"
     CDS             1..187
                     /gene="Crh"
                     /gene_synonym="CRF; Gm1347"
                     /coded_by="NM_205769.3:245..808"
                     /db_xref="CCDS:CCDS17258.1"
                     /db_xref="GeneID:12918"
                     /db_xref="MGI:MGI:88496"
ORIGIN      
        1 mrlrllvsag mllvalsscl pcrallsrgs vpraprapqp lnflqpeqpq qpqpvlirmg
       61 eeyflrlgnl nrspaarlsp nstpltagrg srpshdqaaa nffrvllqql qmpqrsldsr
      121 aepaergaed algghqgale rerrseeppi sldltfhllr evlemaraeq laqqahsnrk
      181 lmeiigk
//
LOCUS       NP_032368                305 aa            linear   ROD 27-AUG-2025
DEFINITION  insulin-like growth factor-binding protein 2 isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_032368
VERSION     NP_032368.2
DBSOURCE    REFSEQ: accession NM_008342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 305)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 305)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   3  (residues 1 to 305)
  AUTHORS   Yoshimura,Y., Watanabe,T., Nakamura,K., Futatsugi,A., Mikoshiba,K.
            and Hiyama,T.Y.
  TITLE     High-temperature exposure during the early embryonic stage lowers
            core body temperature after growth via a hypothalamic
            Igfbp2-dependent mechanism
  JOURNAL   Sci Rep 14 (1), 29586 (2024)
   PUBMED   39627352
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 305)
  AUTHORS   Wang,Z., Li,Z., Luan,T., Cui,G., Shu,S., Liang,Y., Zhang,K.,
            Xiao,J., Yu,W., Cui,J., Li,A., Peng,G. and Fang,Y.
  TITLE     A spatiotemporal molecular atlas of mouse spinal cord injury
            identifies a distinct astrocyte subpopulation and therapeutic
            potential of IGFBP2
  JOURNAL   Dev Cell 59 (20), 2787-2803 (2024)
   PUBMED   39029468
  REMARK    GeneRIF: A spatiotemporal molecular atlas of mouse spinal cord
            injury identifies a distinct astrocyte subpopulation and
            therapeutic potential of IGFBP2.
REFERENCE   5  (residues 1 to 305)
  AUTHORS   Shigetomi,E., Suzuki,H., Hirayama,Y.J., Sano,F., Nagai,Y.,
            Yoshihara,K., Koga,K., Tateoka,T., Yoshioka,H., Shinozaki,Y.,
            Kinouchi,H., Tanaka,K.F., Bito,H., Tsuda,M. and Koizumi,S.
  TITLE     Disease-relevant upregulation of P2Y1 receptor in astrocytes
            enhances neuronal excitability via IGFBP2
  JOURNAL   Nat Commun 15 (1), 6525 (2024)
   PUBMED   39117630
  REMARK    GeneRIF: Disease-relevant upregulation of P2Y1 receptor in
            astrocytes enhances neuronal excitability via IGFBP2.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 305)
  AUTHORS   Kou,K., James,P.L., Clemmons,D.R., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Rotwein,P.
  TITLE     Identification of two clusters of mouse insulin-like growth factor
            binding protein genes on chromosomes 1 and 11
  JOURNAL   Genomics 21 (3), 653-655 (1994)
   PUBMED   7525452
REFERENCE   7  (residues 1 to 305)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   8  (residues 1 to 305)
  AUTHORS   Hakeda,Y., Yoshizawa,K., Hurley,M., Kawaguchi,H., Tezuka,K.,
            Tanaka,K., Satoh,T. and Kumegawa,M.
  TITLE     Stimulatory effect of a phorbol ester on expression of insulin-like
            growth factor (IGF) binding protein-2 and level of IGF-I receptors
            in mouse osteoblastic MC3T3-E1 cells
  JOURNAL   J Cell Physiol 158 (3), 444-450 (1994)
   PUBMED   7510294
REFERENCE   9  (residues 1 to 305)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   10 (residues 1 to 305)
  AUTHORS   Agarwal,N., Hsieh,C.L., Sills,D., Swaroop,M., Desai,B., Francke,U.
            and Swaroop,A.
  TITLE     Sequence analysis, expression and chromosomal localization of a
            gene, isolated from a subtracted human retina cDNA library, that
            encodes an insulin-like growth factor binding protein (IGFBP2)
  JOURNAL   Exp Eye Res 52 (5), 549-561 (1991)
   PUBMED   1712312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121498.12 and AC115870.18.
            
            On Jun 19, 2003 this sequence version replaced NP_032368.1.
            
            Summary: The protein encoded by this gene is one of several similar
            proteins that bind insulin-like growth factors I and II (Igf-I and
            Igf-II). The encoded protein can be secreted into the bloodstream,
            where it binds Igf-I and Igf-II with high affinity, or it can
            remain intracellular, interacting with many different ligands. Two
            transcript variants, one encoding a secreted isoform and the other
            encoding a nonsecreted isoform, have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054473.1, X81580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.94 cM"
     Protein         1..305
                     /product="insulin-like growth factor-binding protein 2
                     isoform 1 precursor"
                     /note="IGF-binding protein 2"
                     /calculated_mol_wt=29545
     sig_peptide     1..34
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3320
     Region          38..116
                     /region_name="IB"
                     /note="Insulin growth factor-binding protein homologues;
                     smart00121"
                     /db_xref="CDD:197525"
     Region          207..286
                     /region_name="Thyroglobulin_1"
                     /note="Thyroglobulin type-1 repeat; pfam00086"
                     /db_xref="CDD:459665"
     Site            order(211,236,254,262)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     CDS             1..305
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /coded_by="NM_008342.4:90..1007"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15036.1"
                     /db_xref="GeneID:16008"
                     /db_xref="MGI:MGI:96437"
ORIGIN      
        1 mlprlggpal plllpsllll lllgaggcgp gvraevlfrc ppctperlaa cgpppdapca
       61 elvrepgcgc csvcarqege acgvyiprca qtlrcypnpg selplkalvt gagtcekrrv
      121 gttpqqvads dddhsegglv enhvdgtmnm lgggssagrk plksgmkela vfrekvneqh
      181 rqmgkgakhl sleepkklrp ppartpcqqe ldqvlerist mrlpddrgpl ehlyslhipn
      241 cdkhgrynlk qckmslngqr gecwcvnpnt gkpiqgapti rgdpechlfy neqqetggah
      301 aqsvq
//
LOCUS       NP_034884                467 aa            linear   ROD 27-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 2 isoform 1 [Mus musculus].
ACCESSION   NP_034884
VERSION     NP_034884.2
DBSOURCE    REFSEQ: accession NM_010754.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 467)
  AUTHORS   Michaels,J.R., Iyyanar,P.P.R., Husami,A., Vontell,A.M.,
            Brugmann,S.A. and Stottmann,R.W.
  TITLE     Genetic analysis and functional assessment of a TGFBR2 variant in
            micrognathia and cleft palate
  JOURNAL   PLoS One 20 (6), e0324803 (2025)
   PUBMED   40489498
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 467)
  AUTHORS   Hrncir,H.R., Goodloe,B., Bombin,S., Hogan,C.B., Jadi,O. and
            Gracz,A.D.
  TITLE     Sox9 inhibits Activin A to promote biliary maturation and branching
            morphogenesis
  JOURNAL   Nat Commun 16 (1), 1667 (2025)
   PUBMED   39955269
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 467)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   4  (residues 1 to 467)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 467)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 467)
  AUTHORS   Dick,A., Risau,W. and Drexler,H.
  TITLE     Expression of Smad1 and Smad2 during embryogenesis suggests a role
            in organ development
  JOURNAL   Dev Dyn 211 (4), 293-305 (1998)
   PUBMED   9566949
REFERENCE   7  (residues 1 to 467)
  AUTHORS   Waldrip,W.R., Bikoff,E.K., Hoodless,P.A., Wrana,J.L. and
            Robertson,E.J.
  TITLE     Smad2 signaling in extraembryonic tissues determines
            anterior-posterior polarity of the early mouse embryo
  JOURNAL   Cell 92 (6), 797-808 (1998)
   PUBMED   9529255
REFERENCE   8  (residues 1 to 467)
  AUTHORS   Devereux,T.R., Anna,C.H., Patel,A.C., White,C.M., Festing,M.F. and
            You,M.
  TITLE     Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1):
            candidates for murine lung tumor resistance and suppressor genes
  JOURNAL   Carcinogenesis 18 (9), 1751-1755 (1997)
   PUBMED   9328171
REFERENCE   9  (residues 1 to 467)
  AUTHORS   Chen,Y., Lebrun,J.J. and Vale,W.
  TITLE     Regulation of transforming growth factor beta- and activin-induced
            transcription by mammalian Mad proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12992-12997 (1996)
   PUBMED   8917532
REFERENCE   10 (residues 1 to 467)
  AUTHORS   Baker,J.C. and Harland,R.M.
  TITLE     A novel mesoderm inducer, Madr2, functions in the activin signal
            transduction pathway
  JOURNAL   Genes Dev 10 (15), 1880-1889 (1996)
   PUBMED   8756346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU058005.1, AK007817.1, AC164009.3, BC058713.1, CN456711.1 and
            BM248478.2.
            
            On Jun 10, 2003 this sequence version replaced NP_034884.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007817.1, BC021342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 51.42 cM"
     Protein         1..467
                     /product="mothers against decapentaplegic homolog 2
                     isoform 1"
                     /note="mothers against decapentaplegic homolog 2;
                     mad-related protein 2; mothers against DPP homolog 2; Smad
                     2; MAD homolog 2"
                     /calculated_mol_wt=52135
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Region          8..172
                     /region_name="MH1_SMAD_2_3"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD2 and
                     SMAD3; cd10491"
                     /db_xref="CDD:199815"
     Site            8
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            19
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            order(43,47,110,114..118,121,140..141)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199815"
     Site            order(74,149,161,166)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199815"
     Region          207..251
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62432.2)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Region          221..225
                     /region_name="PY-motif. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62432.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CAMK2.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            245
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Region          266..456
                     /region_name="MH2_SMAD_2_3"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD2 and
                     SMAD3; cd10985"
                     /db_xref="CDD:199826"
     Site            order(283,288..289,291,302..306,310,314,317,319..320,
                     326..327,329..331,334,403,406,409,413,415,419..421,426,
                     428,432,437,439,441,443,446..447,449..450,453..454)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199826"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            464
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TGFBR1.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     Site            467
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TGFBR1.
                     /evidence=ECO:0000250|UniProtKB:Q15796,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (Q62432.2)"
     CDS             1..467
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /coded_by="NM_010754.5:332..1735"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29350.1"
                     /db_xref="GeneID:17126"
                     /db_xref="MGI:MGI:108051"
ORIGIN      
        1 mssilpftpp vvkrllgwkk saggsggagg geqngqeekw cekavkslvk klkktgrlde
       61 lekaittqnc ntkcvtipst cseiwglsta ntvdqwdttg lysfseqtrs ldgrlqvshr
      121 kglphviycr lwrwpdlhsh helkaience yafnlkkdev cvnpyhyqrv etpvlppvlv
      181 prhteiltel pplddythsi pentnfpagi epqsnyipet pppgyisedg etsdqqlnqs
      241 mdtgspaels pttlspvnhs ldlqpvtyse pafwcsiayy elnqrvgetf hasqpsltvd
      301 gftdpsnser fclgllsnvn rnatvemtrr higrgvrlyy iggevfaecl sdsaifvqsp
      361 ncnqrygwhp atvckippgc nlkifnnqef aallaqsvnq gfeavyqltr mctirmsfvk
      421 gwgaeyrrqt vtstpcwiel hlngplqwld kvltqmgsps vrcssms
//
LOCUS       NP_001334503             442 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 5 [Mus musculus].
ACCESSION   NP_001334503 XP_017170899
VERSION     NP_001334503.1
DBSOURCE    REFSEQ: accession NM_001347574.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107750.9, CT025631.2 and CU074400.3.
            
            On Dec 1, 2016 this sequence version replaced XP_017170899.1.
            
            Transcript Variant: This variant (11) differs in the 5' UTR and
            uses an alternate in-frame splice site in the 3' coding region,
            compared to variant 3, resulting in an isoform (5) that is shorter
            than isoform 3. Variants 8 through 14 all encode isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.49925.1,
                                           ERR3363660.580225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..442
                     /product="myocyte-specific enhancer factor 2C isoform 5"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=47825
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..442
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347574.2:216..1544"
                     /note="isoform 5 is encoded by transcript variant 11"
                     /db_xref="CCDS:CCDS84043.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv sedvdlllnq rinnsqsaqs latpvvsvat
      301 ptlpgqgmgg ypsaisttyg teyslssadl sslsgfntas alhlgsvtgw qqqhlhnmpp
      361 salsqlgdrt ttpsrypqht trheagrspv dslsscsssy dgsdredhrn efhspigltr
      421 pspderesps vkrmrlsegw at
//
LOCUS       NP_001077397             764 aa            linear   ROD 27-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform 3 [Mus musculus].
ACCESSION   NP_001077397
VERSION     NP_001077397.1
DBSOURCE    REFSEQ: accession NM_001083928.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Kalita,B., Sahu,S., Bharadwaj,A., Panneerselvam,L.,
            Martinez-Cebrian,G., Agarwal,M. and Mathew,S.J.
  TITLE     The Wnt-pathway corepressor TLE3 interacts with the histone
            methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma
  JOURNAL   Oncogene 43 (7), 524-538 (2024)
   PUBMED   38177411
  REMARK    GeneRIF: The Wnt-pathway corepressor TLE3 interacts with the
            histone methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma.
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Kumar,P., Zehra,A., Saini,M. and Mathew,S.J.
  TITLE     Zeb1 and Tle3 are trans-factors that differentially regulate the
            expression of myosin heavy chain-embryonic and skeletal muscle
            differentiation
  JOURNAL   FASEB J 37 (8), e23074 (2023)
   PUBMED   37392376
  REMARK    GeneRIF: Zeb1 and Tle3 are trans-factors that differentially
            regulate the expression of myosin heavy chain-embryonic and
            skeletal muscle differentiation.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Leon,C. and Lobe,C.G.
  TITLE     Grg3, a murine Groucho-related gene, is expressed in the developing
            nervous system and in mesenchyme-induced epithelial structures
  JOURNAL   Dev Dyn 208 (1), 11-24 (1997)
   PUBMED   8989517
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Koop,K.E., MacDonald,L.M. and Lobe,C.G.
  TITLE     Transcripts of Grg4, a murine groucho-related gene, are detected in
            adjacent tissues to other murine neurogenic gene homologues during
            embryonic development
  JOURNAL   Mech Dev 59 (1), 73-87 (1996)
   PUBMED   8892234
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Dehni,G., Liu,Y., Husain,J. and Stifani,S.
  TITLE     TLE expression correlates with mouse embryonic segmentation,
            neurogenesis, and epithelial determination
  JOURNAL   Mech Dev 53 (3), 369-381 (1995)
   PUBMED   8645603
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Mallo,M., Gendron-Maguire,M., Harbison,M.L. and Gridley,T.
  TITLE     Protein characterization and targeted disruption of Grg, a mouse
            gene related to the groucho transcript of the Drosophila Enhancer
            of split complex
  JOURNAL   Dev Dyn 204 (3), 338-347 (1995)
   PUBMED   8573724
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611599.1, BQ770333.1, AK122524.1, AC126672.3 and BX630781.1.
            
            Transcript Variant: This variant (3) has multiple differences in
            the coding region compared to variant 1. The resulting protein
            (isoform 3) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.27 cM"
     Protein         1..764
                     /product="transducin-like enhancer protein 3 isoform 3"
                     /note="transducin-like enhancer protein 3; grg-3;
                     transducin-like enhancer of split 3, homolog of Drosophila
                     E(spl)"
                     /calculated_mol_wt=82553
     Region          1..131
                     /region_name="Q domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          18..133
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          130..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          132..199
                     /region_name="GP domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          184..347
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          200..268
                     /region_name="CcN domain.
                     /evidence=ECO:0000250|UniProtKB:Q04724"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Site            203
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            211
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            217
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          225..228
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Site            232
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            245
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          <251..464
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Site            259
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            263
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            267
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            275
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q04727; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            312
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04726; propagated from
                     UniProtKB/Swiss-Prot (Q08122.3)"
     Region          476..514
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          <477..762
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          481..520
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          522..561
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          528..566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          566..605
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          571..607
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          608..647
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          614..649
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          649..688
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          654..687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          690..729
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          695..729
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          731..763
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q08122.3)"
     Region          736..760
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..764
                     /gene="Tle3"
                     /gene_synonym="2610103N05Rik; ESG; Grg3a; Grg3b;
                     mKIAA1547"
                     /coded_by="NM_001083928.1:1073..3367"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS52824.1"
                     /db_xref="GeneID:21887"
                     /db_xref="MGI:MGI:104634"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg algsqahlav
      181 kdeknhheld hreresstnn svspseslra sekhrgsady smeakkrkae ekdslsryds
      241 dgdksddlvv dvsnedpatp rvspahsppe ngldkarglk kdaptspasv asssstpssk
      301 tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi asalrtpitl
      361 tssypapfam mshhemngsl tspsayaglh nipsqmsaaa aaaaaaygrs pmvgfdphpp
      421 mratglpssl asipggkpay sfhvsadgqm qpvpfphdal agpgiprhar qintlshgev
      481 vcavtisnpt rhvytggkgc vkiwdisqpg skspisqldc lnrdnyirsc kllpdgrtli
      541 vggeastlti wdlasptpri kaeltssapa cyalaispda kvcfsccsdg niavwdlhnq
      601 tlvrqfqght dgascidish dgtklwtggl dntvrswdlr egrqlqqhdf tsqifslgyc
      661 ptgewlavgm essnvevlhh tkpdkyqlhl hescvlslkf aycgkwfvst gkdnllnawr
      721 tpygasifqs kesssvlscd isaddkyivt gsgdkkatvy eviy
//
LOCUS       NP_038870                267 aa            linear   ROD 27-AUG-2025
DEFINITION  X-box-binding protein 1 isoform XBP1(U) [Mus musculus].
ACCESSION   NP_038870
VERSION     NP_038870.2
DBSOURCE    REFSEQ: accession NM_013842.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 267)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 267)
  AUTHORS   Touvier,T., Veneri,F.A., Claessens,A., Ferri,C., Mastrangelo,R.,
            Sorgiati,N., Bianchi,F., Valenzano,S., Del Carro,U., Rivellini,C.,
            Duong,P., Shy,M.E., Kelly,J.W., Svaren,J., Wiseman,R.L. and
            D'Antonio,M.
  TITLE     Activation of XBP1s attenuates disease severity in models of
            proteotoxic Charcot-Marie-Tooth type 1B
  JOURNAL   Brain 148 (6), 1978-1993 (2025)
   PUBMED   39979221
REFERENCE   3  (residues 1 to 267)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 267)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 267)
  AUTHORS   Barton,B.M., Son,F., Verma,A., Bal,S.K., Tang,Q., Wang,R.,
            Umphred-Wilson,K., Khan,R., Trichka,J., Dong,H., Lentucci,C.,
            Chen,X., Chen,Y., Hong,Y., Duy,C., Elemento,O., Melnick,A.M.,
            Cao,J., Chen,X., Glimcher,L.H. and Adoro,S.
  TITLE     IRE1alpha-XBP1 safeguards hematopoietic stem and progenitor cells
            by restricting pro-leukemogenic gene programs
  JOURNAL   Nat Immunol 26 (2), 200-214 (2025)
   PUBMED   39789376
REFERENCE   6  (residues 1 to 267)
  AUTHORS   Reimold,A.M., Etkin,A., Clauss,I., Perkins,A., Friend,D.S.,
            Zhang,J., Horton,H.F., Scott,A., Orkin,S.H., Byrne,M.C.,
            Grusby,M.J. and Glimcher,L.H.
  TITLE     An essential role in liver development for transcription factor
            XBP-1
  JOURNAL   Genes Dev 14 (2), 152-157 (2000)
   PUBMED   10652269
REFERENCE   7  (residues 1 to 267)
  AUTHORS   Masaki,T., Yoshida,M. and Noguchi,S.
  TITLE     Targeted disruption of CRE-binding factor TREB5 gene leads to
            cellular necrosis in cardiac myocytes at the embryonic stage
  JOURNAL   Biochem Biophys Res Commun 261 (2), 350-356 (1999)
   PUBMED   10425189
REFERENCE   8  (residues 1 to 267)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
REFERENCE   9  (residues 1 to 267)
  AUTHORS   Clauss,I.M., Chu,M., Zhao,J.L. and Glimcher,L.H.
  TITLE     The basic domain/leucine zipper protein hXBP-1 preferentially binds
            to and transactivates CRE-like sequences containing an ACGT core
  JOURNAL   Nucleic Acids Res 24 (10), 1855-1864 (1996)
   PUBMED   8657566
REFERENCE   10 (residues 1 to 267)
  AUTHORS   Clauss,I.M., Gravallese,E.M., Darling,J.M., Shapiro,F.,
            Glimcher,M.J. and Glimcher,L.H.
  TITLE     In situ hybridization studies suggest a role for the basic
            region-leucine zipper protein hXBP-1 in exocrine gland and skeletal
            development during mouse embryogenesis
  JOURNAL   Dev Dyn 197 (2), 146-156 (1993)
   PUBMED   7693055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662876.23, AK007724.1 and BF453945.1.
            
            On Apr 24, 2001 this sequence version replaced NP_038870.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform, XBP1(U).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF027963.3, BC008153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.61 cM"
     Protein         1..267
                     /product="X-box-binding protein 1 isoform XBP1(U)"
                     /note="tax-responsive element-binding protein 5 homolog"
                     /calculated_mol_wt=29488
     Region          35..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17861; propagated from
                     UniProtKB/Swiss-Prot (O35426.2)"
     Region          63..119
                     /region_name="bZIP_XBP1"
                     /note="Basic leucine zipper (bZIP) domain of X-box binding
                     protein 1 (XBP1) and similar proteins: a DNA-binding and
                     dimerization domain; cd14691"
                     /db_xref="CDD:269839"
     Region          65..87
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Region          66..117
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269839"
     Region          69..85
                     /region_name="Nuclear localization signal (NLS).
                     /evidence=ECO:0000250|UniProtKB:P17861"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            order(69..70,72..74,76..81,83..85)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269839"
     Site            order(84,87..88,91..92,94..95,98..99,101..102,105..106,
                     108..109,112..113,115..116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269839"
     Region          91..126
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            181..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            185..186
                     /site_type="cleavage"
                     /note="Cleavage, by HM13/SPP.
                     /evidence=ECO:0000250|UniProtKB:P17861; propagated from
                     UniProtKB/Swiss-Prot (O35426.2)"
     Region          230..256
                     /region_name="Necessary for the translational pausing of
                     its own mRNA. /evidence=ECO:0000250|UniProtKB:P17861"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     CDS             1..267
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /coded_by="NM_013842.3:355..1158"
                     /note="isoform XBP1(U) is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24400.1"
                     /db_xref="GeneID:22433"
                     /db_xref="MGI:MGI:98970"
ORIGIN      
        1 mvvvaaapsa ataapkvlll sgqpasggra lplmvpgpra agseasgtpq arkrqrlthl
       61 speekalrrk lknrvaaqta rdrkkarmse leqqvvdlee enhklqlenq llrekthglv
      121 venqelrtrl gmdtldpdev peveakgsgv rlvagsaesa alrlcaplqq vqaqlsppqn
      181 ifpwtltllp lqilslisfw afwtswtlsc fsnvlpqsll vwrnsqrstq kdlvpyqppf
      241 lcqwgphqps wkplmnsfvl tmytpsl
//
LOCUS       NP_001278162            1613 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 1 isoform c [Mus musculus].
ACCESSION   NP_001278162 XP_006504412
VERSION     NP_001278162.1
DBSOURCE    REFSEQ: accession NM_001291233.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1613)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1613)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1613)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1613)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1613)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 1613)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 1613)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 1613)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1613)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 1613)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Mar 29, 2014 this sequence version replaced XP_006504412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037807.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..1613
                     /product="homeobox protein cut-like 1 isoform c"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=175261
     Region          118..>454
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          643..719
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          843..>1026
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1032..1100
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1215..1292
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1338..1394
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..1613
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_001291233.2:674..5515"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 merasgplra afsspvlesk apgapldcke tdcgsssprg dgigasqsaa elpacpedai
       61 lpatphrnql lalgvlpasa ssafaapgqp qdsarwmlcv agaklkreld atatvlanrq
      121 deseqsrkrl ieqsrefkkn tpedlrkqva pllksfqgei dalskrskea eaafltvykr
      181 lidvpdpvpa ldvgqqleik vqrlhdiete nqklretlee ynkefaevkn qevtikalke
      241 kireyeqtlk sqaetialek eqklqndfae kerklqetqm sttskleeae hklqtlqtal
      301 ektrtelfdl ktkydeetta kadeiemimt dleranqrae vaqreaetlr eqlssanhsl
      361 qlasqiqkap dveqaievlt rsslevelaa kereiaqlve dvqrlqaslt klrensasqi
      421 sqleqqlnak nstlkqleek lkgqadyeev kkelntlksm efapsegagt qdstkplevl
      481 lleknrslqs enatlrisns dlsgsarrkg rdqpesrrpg plpaspppql prntgeqvsn
      541 tngthhfspa glsqdffssn laspslplas tgkfalnsll qrqlmqsfys kamqeagsts
      601 tifstgpyst nsisspsplq qspdvngmap spsqsesags isegeeidta eiarqvkeql
      661 ikhnigqrif ghyvlglsqg svseilarpk pwnkltvrgk epfhkmkqfl sdeqnilalr
      721 siqgrqrenp gqslnrlfqe vpkrrngseg nittrirase tgsdeaiksi leqakrelqv
      781 qktaepvqts stsssgnsdd airsilqqar remeaqqaal dpalkpapls qpdltiltpk
      841 hlsaspmstv stypplaisl kktpaapets taalpsapal kkeaqdvptl dppgsadaaq
      901 gvlrpmksel vrgstwkdpw wspiqperrn ltsseetkad ettasgkera gssqpraers
      961 qlqgpsasae ywkewpsaes pysqsselsl tgasrsetpq nsplpsspiv pmakpakpsv
     1021 ppltpeqyev ymyqevdtie ltrqvkekla kngicqrifg ekvlglsqgs vsdmlsrpkp
     1081 wskltqkgre pfirmqlwln gelgqgvlpv qgqqqgpvlh svaslqdplq qgcvssestp
     1141 ktsascspap espmsssesv ksltelvqqp cpaietskeg kppepsdppa sdsqpttplp
     1201 lsghsalsiq elvamspeld tygitkrvke vltdnnlgqr lfgetilglt qgsvsdllar
     1261 pkpwhklslk grepfvrmql wlndpnnvek lmdmkrmekk aymkrrhssv sdsqpcepps
     1321 vgidysqgas pqpqhqlkkp rvvlapeeke alkrayqqkp ypspktieel atqlnlktst
     1381 vinwfhnyrs rirrelfiee iqagsqgqag asdspsarss raapssegds cdgveatdae
     1441 epggnivatk sqgglaevaa apadreeatq paekakaqpl csgtpgqddg edasrprplp
     1501 egladapapv pslaapaage daatsatapa tateapgaar agpaerssal pstsapanap
     1561 arrpsslqsl fglpeaagar dnlvrkkkaa nlnsiihrle kaasreepie wef
//
LOCUS       NP_001289108             463 aa            linear   ROD 27-AUG-2025
DEFINITION  transcriptional regulator ERG isoform 5 [Mus musculus].
ACCESSION   NP_001289108
VERSION     NP_001289108.1
DBSOURCE    REFSEQ: accession NM_001302179.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 463)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 463)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 463)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   4  (residues 1 to 463)
  AUTHORS   Yamashita,T., Kaplan,U., Chakraborty,A., Marden,G., Gritli,S.,
            Roh,D., Bujor,A., Trojanowski,M., Ligresti,G., Browning,J.L. and
            Trojanowska,M.
  TITLE     ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis
  JOURNAL   Arthritis Rheumatol 76 (11), 1645-1657 (2024)
   PUBMED   38965683
  REMARK    GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
REFERENCE   5  (residues 1 to 463)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
REFERENCE   6  (residues 1 to 463)
  AUTHORS   Fan,C.M., Kuwana,E., Bulfone,A., Fletcher,C.F., Copeland,N.G.,
            Jenkins,N.A., Crews,S., Martinez,S., Puelles,L., Rubenstein,J.L.
            and Tessier-Lavigne,M.
  TITLE     Expression patterns of two murine homologs of Drosophila
            single-minded suggest possible roles in embryonic patterning and in
            the pathogenesis of Down syndrome
  JOURNAL   Mol Cell Neurosci 7 (1), 1-16 (1996)
   PUBMED   8812055
  REMARK    Erratum:[Mol Cell Neurosci 1996 Jun;7(6):519]
REFERENCE   7  (residues 1 to 463)
  AUTHORS   Mjaatvedt,A.E., Cabin,D.E., Cole,S.E., Long,L.J., Breitwieser,G.E.
            and Reeves,R.H.
  TITLE     Assessment of a mutation in the H5 domain of Girk2 as a candidate
            for the weaver mutation
  JOURNAL   Genome Res 5 (5), 453-463 (1995)
   PUBMED   8808466
REFERENCE   8  (residues 1 to 463)
  AUTHORS   Rivera,R.R., Stuiver,M.H., Steenbergen,R. and Murre,C.
  TITLE     Ets proteins: new factors that regulate immunoglobulin heavy-chain
            gene expression
  JOURNAL   Mol Cell Biol 13 (11), 7163-7169 (1993)
   PUBMED   8413305
REFERENCE   9  (residues 1 to 463)
  AUTHORS   Mjaatvedt,A.E., Citron,M.P. and Reeves,R.H.
  TITLE     High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and
            Erg on distal mouse chromosome 16
  JOURNAL   Genomics 17 (2), 382-386 (1993)
   PUBMED   8406490
REFERENCE   10 (residues 1 to 463)
  AUTHORS   Reddy,E.S., Rao,V.N. and Papas,T.S.
  TITLE     The erg gene: a human gene related to the ets oncogene
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6131-6135 (1987)
   PUBMED   3476934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050922.1, AK078113.1, AC154691.3 and BP753340.1.
            
            Transcript Variant: This variant (5) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The encoded
            isoform (5) is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.04 cM"
     Protein         1..463
                     /product="transcriptional regulator ERG isoform 5"
                     /note="transcriptional regulator ERG; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related"
                     /calculated_mol_wt=51841
     Region          122..205
                     /region_name="SAM_superfamily"
                     /note="SAM (Sterile alpha motif); cl15755"
                     /db_xref="CDD:472832"
     Region          294..377
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..463
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /coded_by="NM_001302179.1:152..1543"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS79496.1"
                     /db_xref="GeneID:13876"
                     /db_xref="MGI:MGI:95415"
ORIGIN      
        1 miqtvpdpaa hikealsvvs edqslfecay gtphlaktem tassssdygq tskmsprvpq
       61 qdwlsqapar vtikmecnps qvngsrnspd ecsvnkggkm vgspdtvgms ygsymeekhv
      121 pppnmttner rvivpadptl wstdhvrqwl ewavkeygll dvdvllfqni dgkelckmtk
      181 ddfqrltpsy nadillshlh ylretplphl tsddvdkalq nsprlmharn tggaafifpn
      241 tsvypeatqr ittrpaaqps psavpktedq rpqldpyqil gptssrlanp gsgqiqlwqf
      301 llellsdssn sncitwegtn gefkmtdpde varrwgerks kpnmnydkls ralryyydkn
      361 imtkvhgkry aykfdfhgia qalqphppes slykypsdlp ymgsyhahpq kmnfvsphpp
      421 alpvtsssff aspnpywnsp tggiypntrl pashmpshlg tyy
//
LOCUS       NP_034372                433 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-(1,3)-fucosyltransferase 4 [Mus musculus].
ACCESSION   NP_034372
VERSION     NP_034372.1
DBSOURCE    REFSEQ: accession NM_010242.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Zhao,B.W., Zhang,Y.N., Meng,T.G., Xu,Y.H., Lu,Y.K., Sun,S.M.,
            Guo,J.N., Yang,X.M. and Wang,Z.B.
  TITLE     Re-establishment of H3K9me2 eliminates the transcriptional
            inhibition of ST18 on meiotic genes and orchestrates female germ
            cell development
  JOURNAL   Nucleic Acids Res 53 (13) (2025)
   PUBMED   40650982
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Liu,W., Xiong,W., Liu,W., Hirakawa,J. and Kawashima,H.
  TITLE     A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans
            attenuates murine allergic rhinitis by suppressing Th2 immune
            responses
  JOURNAL   Sci Rep 13 (1), 15740 (2023)
   PUBMED   37735247
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Zhou,Z., Yin,H., Suye,S., Ren,Z., Yan,L., Shi,L. and Fu,C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Filali,M., Lalonde,R., Bensoula,A.N., Guastavino,J.M. and
            Lestienne,F.
  TITLE     Spontaneous alternation, motor activity, and spatial learning in
            hot-foot mutant mice
  JOURNAL   J Comp Physiol A 178 (1), 101-104 (1996)
   PUBMED   8568721
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Gersten,K.M., Natsuka,S., Trinchera,M., Petryniak,B., Kelly,R.J.,
            Hiraiwa,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Lowe,J.B.
  TITLE     Molecular cloning, expression, chromosomal assignment, and
            tissue-specific expression of a murine
            alpha-(1,3)-fucosyltransferase locus corresponding to the human
            ELAM-1 ligand fucosyl transferase
  JOURNAL   J Biol Chem 270 (42), 25047-25056 (1995)
   PUBMED   7559635
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Marcus,R.C. and Mason,C.A.
  TITLE     The first retinal axon growth in the mouse optic chiasm: axon
            patterning and the cellular environment
  JOURNAL   J Neurosci 15 (10), 6389-6402 (1995)
   PUBMED   7472403
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Fox,N., Damjanov,I., Martinez-Hernandez,A., Knowles,B.B. and
            Solter,D.
  TITLE     Immunohistochemical localization of the early embryonic antigen
            (SSEA-1) in postimplantation mouse embryos and fetal and adult
            tissues
  JOURNAL   Dev Biol 83 (2), 391-398 (1981)
   PUBMED   6113181
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Solter,D. and Knowles,B.B.
  TITLE     Monoclonal antibody defining a stage-specific mouse embryonic
            antigen (SSEA-1)
  JOURNAL   Proc Natl Acad Sci U S A 75 (11), 5565-5569 (1978)
   PUBMED   281705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK041752.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK041752.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.3 cM"
     Protein         1..433
                     /product="alpha-(1,3)-fucosyltransferase 4"
                     /EC_number="2.4.1.152"
                     /note="stage-specific embryonic antigen 1; galactoside
                     3-L-fucosyltransferase; Lewis x; alpha
                     1,3-fucosyltransferase; fuc-TIV; fucosyltransferase IV;
                     alpha (1,3) fucosyltransferase, myeloid specific;
                     3-fucosyl-N-acetyl-lactosamine epitope;
                     4-galactosyl-N-acetylglucosaminide
                     3-alpha-L-fucosyltransferase"
                     /calculated_mol_wt=49350
     Site            53..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q11127.1)"
     Region          87..234
                     /region_name="Glyco_tran_10_N"
                     /note="Fucosyltransferase, N-terminal; pfam17039"
                     /db_xref="CDD:465336"
     Site            117
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q11127.1)"
     Site            218
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q11127.1)"
     Region          253..430
                     /region_name="Glyco_transf_10"
                     /note="Glycosyltransferase family 10 (fucosyltransferase)
                     C-term; pfam00852"
                     /db_xref="CDD:459962"
     CDS             1..433
                     /gene="Fut4"
                     /gene_synonym="CD15; FAL; FucT-IV; LeX; SSEA-1; Ssea1"
                     /coded_by="NM_010242.3:127..1428"
                     /db_xref="CCDS:CCDS22825.1"
                     /db_xref="GeneID:14345"
                     /db_xref="MGI:MGI:95594"
ORIGIN      
        1 maparqelqh esrcrpsrtv dawraavatr grhmetpgyr rrtrcggwgl prsvsslaav
       61 gllctalttf icwgqlpplp waspapqrlv gvllwwepfr grggypkspp dcslrfnisg
      121 crlltdraay geaqavlfhh rdlvkelhdw pppwgarert dkalvlrvfd dqegavtltg
      181 kaletvgsrp pgqrwvwmnf espshtpglr glakdlfnwt lsyrtdsdvf vpygflysrs
      241 dpteqpsglg pqlarkrglv awvvsnwneh qarvryyhql srhvsvdvfg rtgpgrpvpa
      301 igllhtvary kfylafensr hvdyiteklw rnaflagavp vvlgpdrany erfvprgafi
      361 hvddfpnaas laayllfldr nvavyrryfr wrrsfavhit sfwdeqwcrt cqavqtsgdq
      421 pksihnladw fqr
//
LOCUS       NP_001274109             349 aa            linear   ROD 27-AUG-2025
DEFINITION  cyclic AMP-dependent transcription factor ATF-4 [Mus musculus].
ACCESSION   NP_001274109
VERSION     NP_001274109.1
DBSOURCE    REFSEQ: accession NM_001287180.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Wang,K., Farrell,A., Zhou,E., Qin,H., Zeng,Z., Zhou,K., Cunha E
            Rocha,K., Zhang,D., Wang,G., Atakilit,A., Sheppard,D., Lu,L.F.,
            Jin,C. and Ying,W.
  TITLE     ATF4 drives regulatory T cell functional specification in
            homeostasis and obesity
  JOURNAL   Sci Immunol 10 (105), eadp7193 (2025)
   PUBMED   40085690
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Zhu,S., Huo,S., He,W., Huang,C., Zhang,J., Jiang,X., Qian,Y.,
            Chen,C., Dai,Z.M., Yang,X., Qiu,M., Li,T. and Zhu,X.J.
  TITLE     Fine-tuning of Wnt signaling by RNA surveillance factor Smg5 in the
            mouse craniofacial development
  JOURNAL   iScience 28 (3), 111972 (2025)
   PUBMED   40071146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 349)
  AUTHORS   Yang,L.X., Qi,C., Lu,S., Ye,X.S., Merikhian,P., Zhang,D.Y., Yao,T.,
            Zhao,J.S., Wu,Y., Jia,Y., Shan,B., Chen,J., Mou,X., You,J., Li,W.
            and Feng,Y.X.
  TITLE     Alleviation of liver fibrosis by inhibiting a non-canonical
            ATF4-regulated enhancer program in hepatic stellate cells
  JOURNAL   Nat Commun 16 (1), 524 (2025)
   PUBMED   39789010
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 349)
  AUTHORS   Vattem,K.M. and Wek,R.C.
  TITLE     Reinitiation involving upstream ORFs regulates ATF4 mRNA
            translation in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (31), 11269-11274 (2004)
   PUBMED   15277680
  REMARK    GeneRIF: delayed reinitiation allows for ribosomes to scan through
            the inhibitory uORF2 and instead reinitiate at the ATF4-coding
            region.
REFERENCE   7  (residues 1 to 349)
  AUTHORS   Lee,F.S., Lane,T.F., Kuo,A., Shackleford,G.M. and Leder,P.
  TITLE     Insertional mutagenesis identifies a member of the Wnt gene family
            as a candidate oncogene in the mammary epithelium of int-2/Fgf-3
            transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2268-2272 (1995)
   PUBMED   7892260
REFERENCE   8  (residues 1 to 349)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (residues 1 to 349)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   10 (residues 1 to 349)
  AUTHORS   Mielnicki,L.M. and Pruitt,S.C.
  TITLE     Isolation and nucleotide sequence of a murine cDNA homologous to
            human activating transcription factor 4
  JOURNAL   Nucleic Acids Res 19 (22), 6332 (1991)
   PUBMED   1956797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003001.1, BC085169.1, AA003141.1 and BE992821.1.
            
            Transcript Variant: This variant (2) lacks an internal segment in
            the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA003141.1, SRR5189676.61428.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 15277680
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     Protein         1..349
                     /product="cyclic AMP-dependent transcription factor ATF-4"
                     /note="taxREB67 homolog; c/EBP-related ATF; cAMP-dependent
                     transcription factor ATF-4; tax-responsive enhancer
                     element-binding protein 67 homolog; cAMP-responsive
                     element-binding protein 2; cyclic AMP-responsive
                     element-binding protein 2"
                     /calculated_mol_wt=38224
     Region          49..75
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            60
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000269|PubMed:24809345; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          204..271
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          214..223
                     /region_name="BetaTrCP degron motif.
                     /evidence=ECO:0000269|PubMed:23663782"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            214
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P18848; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            234
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            235
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000269|PubMed:24809345; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23663782; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KA3.
                     /evidence=ECO:0000269|PubMed:15109498; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     Region          277..339
                     /region_name="bZIP_ATF4"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-4 (ATF-4) and similar proteins: a
                     DNA-binding and dimerization domain; cd14692"
                     /db_xref="CDD:269840"
     Region          278..298
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Region          279..338
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269840"
     Region          279..298
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            order(282..283,285..287,289..294,296..298)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269840"
     Site            order(301,304,307..308,311..312,314..315,318..319,
                     321..322,325,328..329,332..333,335..336)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269840"
     Region          303..339
                     /region_name="Interaction with GABBR1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Region          304..332
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q06507.2)"
     Site            309
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P18848; propagated from
                     UniProtKB/Swiss-Prot (Q06507.2)"
     CDS             1..349
                     /gene="Atf4"
                     /gene_synonym="Atf-4; C/ATF; CREB-2; CREB2; TAXREB67"
                     /coded_by="NM_001287180.1:312..1361"
                     /db_xref="CCDS:CCDS37145.1"
                     /db_xref="GeneID:11911"
                     /db_xref="MGI:MGI:88096"
ORIGIN      
        1 mtemsflnse vlagdlmspf dqsglgaees lgllddylev akhlkphgfs sdkagssewp
       61 amddglasas dtgkedafsg tdwmlekmdl kefdfdalfr mddletmpde llttlddtcd
      121 lfaplvqetn keppqtvnpi ghlpeslikv dqvapftflq pfpcspgvls stpehsfsle
      181 lgsevdiseg drkpdsaayi tlippcvkee dtpsdndsgi cmspesylgs pqhspstsra
      241 ppdnlpspgg srgsprpkpy dppgvsltak vktekldkkl kkmeqnktaa tryrqkkrae
      301 qealtgecke lekknealke kadslakeiq ylkdlieevr kargkkrvp
//
LOCUS       NP_001289460             599 aa            linear   ROD 27-AUG-2025
DEFINITION  estrogen receptor isoform 1 [Mus musculus].
ACCESSION   NP_001289460 XP_006512495
VERSION     NP_001289460.1
DBSOURCE    REFSEQ: accession NM_001302531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Zha,X., Liu,X.Y., Wang,L., Li,S.S., Sun,Y.Z., Lin,J.K., Yan,J.J.,
            Gao,M.T., Zhang,Y.L., Yang,R.R., Xu,C. and Xu,X.H.
  TITLE     Estrogen signaling in the ventromedial hypothalamus is required for
            the development of aggression circuitry in male mice
  JOURNAL   Curr Biol 35 (11), 2684-2696 (2025)
   PUBMED   40403719
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Terakawa,J., Nakamura,S., Ohtomo,M., Uehara,S., Kawata,Y.,
            Takarabe,S., Sugita,H., Namiki,T., Kageyama,A., Noguchi,M.,
            Murakami,H., Kashiwazaki,N. and Ito,J.
  TITLE     LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo
            Implantation in Mice
  JOURNAL   Biomolecules 15 (5), 698 (2025)
   PUBMED   40427591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 599)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 599)
  AUTHORS   Wu,T.C., Wang,L. and Wan,Y.J.
  TITLE     Expression of estrogen receptor gene in mouse oocyte and during
            embryogenesis
  JOURNAL   Mol Reprod Dev 33 (4), 407-412 (1992)
   PUBMED   1472372
REFERENCE   7  (residues 1 to 599)
  AUTHORS   Greco,T.L., Furlow,J.D., Duello,T.M. and Gorski,J.
  TITLE     Immunodetection of estrogen receptors in fetal and neonatal female
            mouse reproductive tracts
  JOURNAL   Endocrinology 129 (3), 1326-1332 (1991)
   PUBMED   1874174
REFERENCE   8  (residues 1 to 599)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   9  (residues 1 to 599)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (residues 1 to 599)
  AUTHORS   White,R., Lees,J.A., Needham,M., Ham,J. and Parker,M.
  TITLE     Structural organization and expression of the mouse estrogen
            receptor
  JOURNAL   Mol Endocrinol 1 (10), 735-744 (1987)
   PUBMED   2484714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153573.3 and AC156393.12.
            
            On Oct 28, 2014 this sequence version replaced XP_006512495.1.
            
            Summary: This gene encodes an estrogen receptor, a member of the
            nuclear hormone family of intracellular receptors. The encoded
            protein, activated by the sex hormone estrogen, is a transcription
            factor composed of several domains important for hormone binding,
            DNA binding, and activation of transcription. Estrogen and its
            receptors are essential for sexual development and reproductive
            function, but also play a role in other tissues such as bone.
            Similar genes in human have been implicated in pathological
            processes including breast cancer, endometrial cancer, and
            osteoporosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, and 6 all encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB560752.1, SRR10223970.12161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.03 cM"
     Protein         1..599
                     /product="estrogen receptor isoform 1"
                     /note="estradiol receptor; nuclear receptor subfamily 3
                     group A member 1; C-terminally-truncated estrogen receptor
                     alpha product-5; C-terminally-truncated estrogen receptor
                     alpha product-6; C-terminally-truncated estrogen receptor
                     alpha product-7; C-terminally-truncated estrogen receptor
                     alpha product-4"
                     /calculated_mol_wt=66824
     Region          1..188
                     /region_name="Modulating (transactivation AF-1), mediates
                     interaction with MACROD1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            10
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..178
                     /region_name="Interaction with DDX5, self-association.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..47
                     /region_name="Required for interaction with NCOA1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          42..185
                     /region_name="Oest_recep"
                     /note="Oestrogen receptor; pfam02159"
                     /db_xref="CDD:460469"
     Site            50
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          147..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          184..265
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Region          189..314
                     /region_name="Mediates interaction with DNTTIP2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(189,192,206,209,225,231,241,244)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(198..201,207..208,210..212,214..215,238..239,242,
                     245)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(224..227,231..232,237,240)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          255..314
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            264
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          266..599
                     /region_name="Interaction with AKAP13.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          268..599
                     /region_name="Self-association. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          314..551
                     /region_name="NR_LBD_ER"
                     /note="Ligand binding domain of Estrogen receptor, which
                     are activated by the hormone 17beta-estradiol (estrogen);
                     cd06949"
                     /db_xref="CDD:132747"
     Region          315..599
                     /region_name="Transactivation AF-2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(350,355,357,391,398,525,528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132747"
     Site            order(362,366,379..380,384,542,546..547)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            order(455,459,461..462,483,487..488,491,505..506,508..510,
                     512..513,516..517,519..520,523)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            541
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          556..599
                     /region_name="ESR1_C"
                     /note="Oestrogen-type nuclear receptor final C-terminal;
                     pfam12743"
                     /db_xref="CDD:432757"
     Region          557..581
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            575
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831,
                     ECO:0000269|PubMed:8999954. /id=CAR_000137; propagated
                     from UniProtKB/Swiss-Prot (P19785.1)"
     CDS             1..599
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /coded_by="NM_001302531.2:214..2013"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS56678.1"
                     /db_xref="GeneID:13982"
                     /db_xref="MGI:MGI:1352467"
ORIGIN      
        1 mtmtlhtkas gmallhqiqg neleplnrpq lkmpmeralg evyvdnskpt vfnypegaay
       61 efnaaaaaaa aasapvygqs giaygpgsea aafsanslga fpqlnsvsps plmllhpppq
      121 lspflhphgq qvpyylenep sayavrdtgp pafyrsnsdn rrqngrerls ssnekgnmim
      181 esaketryca vcndyasgyh ygvwscegck affkrsiqgh ndymcpatnq ctidknrrks
      241 cqacrlrkcy evgmmkggir kdrrggrmlk hkrqrddleg rnemgasgdm raanlwpspl
      301 vikhtkknsp alsltadqmv salldaeppm iyseydpsrp fseasmmgll tnladrelvh
      361 minwakrvpg fgdlnlhdqv hllecawlei lmiglvwrsm ehpgkllfap nllldrnqgk
      421 cvegmveifd mllatssrfr mmnlqgeefv clksiillns gvytflsstl ksleekdhih
      481 rvldkitdtl ihlmakaglt lqqqhrrlaq lllilshirh msnkgmehly nmkcknvvpl
      541 ydlllemlda hrlhapasrm gvppeepsqt qlattsstsa hslqtyyipp eaegfpnti
//
LOCUS       NP_001277958            1178 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase PRDM16 isoform 4 [Mus musculus].
ACCESSION   NP_001277958 XP_006539240
VERSION     NP_001277958.1
DBSOURCE    REFSEQ: accession NM_001291029.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1178)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1178)
  AUTHORS   Fu,L., Upadhyay,R., Pokrovskii,M., Chen,F.M., Romero-Meza,G.,
            Griesemer,A. and Littman,D.R.
  TITLE     PRDM16-dependent antigen-presenting cells induce tolerance to gut
            antigens
  JOURNAL   Nature 642 (8068), 756-765 (2025)
   PUBMED   40228524
REFERENCE   3  (residues 1 to 1178)
  AUTHORS   Zhang,H., Papiernik,T., Tian,S., Yaghmour,A., Alzein,A.,
            Lennon,J.B., Maini,R., Tan,X., Niazi,A., Park,J., Park,S.,
            Richter,C.P. and Ebeid,M.
  TITLE     Kolliker's Organ Functions as a Developmental Hub in Mouse Cochlea
            Regulating Spiral Limbus and Tectorial Membrane Development
  JOURNAL   J Neurosci 45 (13), e0721242025 (2025)
   PUBMED   39909560
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1178)
  AUTHORS   Wang,S., He,T., Luo,Y., Ren,K., Shen,H., Hou,L., Wei,Y., Fu,T.,
            Xie,W., Wang,P., Hu,J., Zhu,Y., Huang,Z., Li,Q., Li,W., Guo,H. and
            Li,B.
  TITLE     SOX4 facilitates brown fat development and maintenance through
            EBF2-mediated thermogenic gene program in mice
  JOURNAL   Cell Death Differ 32 (3), 447-465 (2025)
   PUBMED   39402212
REFERENCE   5  (residues 1 to 1178)
  AUTHORS   Wang,Y., Li,X., Liu,C., Zhou,L., Shi,L., Zhang,Z., Chen,L., Gao,M.,
            Gao,L., Xu,Y., Huang,H., Li,J. and Chen,Z.
  TITLE     WTAP regulates postnatal development of brown adipose tissue by
            stabilizing METTL3 in mice
  JOURNAL   Life Metab 1 (3), 270-284 (2022)
   PUBMED   39872074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1178)
  AUTHORS   Seale,P., Kajimura,S., Yang,W., Chin,S., Rohas,L.M., Uldry,M.,
            Tavernier,G., Langin,D. and Spiegelman,B.M.
  TITLE     Transcriptional control of brown fat determination by PRDM16
  JOURNAL   Cell Metab 6 (1), 38-54 (2007)
   PUBMED   17618855
REFERENCE   7  (residues 1 to 1178)
  AUTHORS   Warner,D.R., Horn,K.H., Mudd,L., Webb,C.L., Greene,R.M. and
            Pisano,M.M.
  TITLE     PRDM16/MEL1: a novel Smad binding protein expressed in murine
            embryonic orofacial tissue
  JOURNAL   Biochim Biophys Acta 1773 (6), 814-820 (2007)
   PUBMED   17467076
  REMARK    GeneRIF: PRDM16/MEL1 is a Smad binding protein that may be
            important for development of orofacial structures through
            modulation of the TGFbeta signaling pathway.
REFERENCE   8  (residues 1 to 1178)
  AUTHORS   Du,Y., Jenkins,N.A. and Copeland,N.G.
  TITLE     Insertional mutagenesis identifies genes that promote the
            immortalization of primary bone marrow progenitor cells
  JOURNAL   Blood 106 (12), 3932-3939 (2005)
   PUBMED   16109773
REFERENCE   9  (residues 1 to 1178)
  AUTHORS   Nishikata,I., Sasaki,H., Iga,M., Tateno,Y., Imayoshi,S., Asou,N.,
            Nakamura,T. and Morishita,K.
  TITLE     A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is
            expressed mainly in t(1;3)(p36;q21)-positive AML and blocks
            G-CSF-induced myeloid differentiation
  JOURNAL   Blood 102 (9), 3323-3332 (2003)
   PUBMED   12816872
REFERENCE   10 (residues 1 to 1178)
  AUTHORS   Herron,B.J., Lu,W., Rao,C., Liu,S., Peters,H., Bronson,R.T.,
            Justice,M.J., McDonald,J.D. and Beier,D.R.
  TITLE     Efficient generation and mapping of recessive developmental
            mutations using ENU mutagenesis
  JOURNAL   Nat Genet 30 (2), 185-189 (2002)
   PUBMED   11818962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627127.20, AL611950.17, AL627226.16 and AL627123.13.
            
            On Mar 22, 2014 this sequence version replaced XP_006539240.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059838.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.96 cM"
     Protein         1..1178
                     /product="histone-lysine N-methyltransferase PRDM16
                     isoform 4"
                     /EC_number="2.1.1.367"
                     /note="transcription factor MEL1; MDS1/EVI1-like gene 1;
                     PR domain-containing protein 16; PR domain zinc finger
                     protein 16; line 27; histone-lysine N-methyltransferase
                     PRDM16"
                     /calculated_mol_wt=130297
     Region          1..66
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          61..223
                     /region_name="PR-SET_PRDM16"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 16 (PRDM16) and similar proteins; cd19213"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,113,158,171..175,177,186..187,211)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,171..175,177,211)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380990"
     Region          233..253
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          283..305
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          285..305
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(290,292,294,296..297,300..301,304,318,320,324..325,
                     328..329,332,346,348,350,352..353,356..357)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          297..321
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          311..333
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          313..333
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          339..360
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          341..359
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          368..390
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          370..390
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          396..418
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          398..418
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          427..445
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          593..659
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          790..839
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          953..975
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          955..975
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(960,962,964,966..967,970..971,974,988,990,994..995,
                     998..999,1003,1017,1019,1021,1023..1024,1027..1028,1031)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          967..991
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          983..>1017
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          983..1009
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          983..1004
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(988,994,1006,1008,1011)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          1010..1032
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          1012..1032
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1029..1067
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          1086..1171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     CDS             1..1178
                     /gene="Prdm16"
                     /gene_synonym="5730557K01Rik; csp1; mel1"
                     /coded_by="NM_001291029.2:58..3594"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS71532.1"
                     /db_xref="GeneID:70673"
                     /db_xref="MGI:MGI:1917923"
ORIGIN      
        1 mrskararkl aksdgdvvnn myepdpdlla gqsaeeeted gilspipmgp pspfptsedf
       61 tpkegspyea pvyipedipi ppdfelress ipgaglgiwa krkmeigerf gpyvvtpraa
      121 lkeadfgweq mltdtevssq escikkqise dlgsekfcvd anqagsgswl kyirvacscd
      181 dqnlamcqin eqiyykvikd iepgeellvh vkegayslgv mapsldedpt frcdecdelf
      241 qcrldlrrhk kyacssagaq lyeglgeelk peglgvgsdg qaheckdcer mfpnkysleq
      301 hmivhteere ykcdqcpkaf nwksnlirhq mshdsgkrfe cencvkvftd psnlqrhirs
      361 qhvgarahac pdcgktfats sglkqhkhih stvkpficev chksytqfsn lcrhkrmhad
      421 crtqikckdc gqmfsttssl nkhrrfcegk nhytpgsift pglpltpspm mdktkpsptl
      481 nhgglgfsey fpsrphpgsl pfsaappafp altpgfpgif ppslyprppl lpptpllksp
      541 lnhaqdaklp splgnpalpl vsavsnssqg ataatgseek fdgrledaya ekvknrspdm
      601 sdgsdfedin tttgtdldtt tgtgsdldsd ldsdrdkgkd kgkpveskpe fggasvppga
      661 mnsvaevpaf ysqhsffppp eeqlltasga agdsikaias iaekyfgpgf msmqekklgs
      721 lpyhsvfpfq flpnfphsly pftdralahn llvkaepksp rdalkvggps aecpfdlttk
      781 pkeakpalla pkvplipssg eeqpldlsig srarasqngg greprknhvy gerkpgvseg
      841 lpkvcpaqlp qqpslhyakp spffmdpiys rvekrkvadp vgvlkekylr pspllfhpqm
      901 saietmtekl esfaamkads gsslqplphh pfnfrspppt lsdpilrkgk erytcrycgk
      961 ifprsanltr hlrthtgeqp yrckycdrsf sissnlqrhv rnihnkekpf kchlcnrcfg
     1021 qqtnldrhlk khehegapvs qhsgvltnhl gtsassptse sdnhalldek edsyfseirn
     1081 fiansemnqa strmdkrpei qdldsnppcp gsasakpedv eeeeeeelee edddslagks
     1141 qedtvsptpe pqgvyedeed eeppsltmgf dhtrrhmq
//
LOCUS       NP_001399255             279 aa            linear   ROD 27-AUG-2025
DEFINITION  D(4) dopamine receptor isoform 3 [Mus musculus].
ACCESSION   NP_001399255 XP_017177461
VERSION     NP_001399255.1
DBSOURCE    REFSEQ: accession NM_001412326.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 279)
  AUTHORS   D'Souza,S.P., Upton,B.A., Eldred,K.C., Glass,I., Nayak,G.,
            Grover,K., Ahmed,A., Nguyen,M.T., Hu,Y.C., Gamlin,P. and Lang,R.A.
  TITLE     Developmental control of rod number via a light-dependent
            retrograde pathway from intrinsically photosensitive retinal
            ganglion cells
  JOURNAL   Dev Cell 59 (21), 2897-2911 (2024)
   PUBMED   39142280
REFERENCE   2  (residues 1 to 279)
  AUTHORS   Peng,H.R., Qiu,J.Q., Zhou,Q.M., Zhang,Y.K., Chen,Q.Y., Yin,Y.Q.,
            Su,W., Yu,S., Wang,Y.T., Cai,Y., Gu,M.N., Zhang,H.H., Sun,Q.Q.,
            Hu,G., Wu,Y.W., Liu,J., Chen,S., Zhu,Z.J., Song,X.Y. and Zhou,J.W.
  TITLE     Intestinal epithelial dopamine receptor signaling drives
            sex-specific disease exacerbation in a mouse model of multiple
            sclerosis
  JOURNAL   Immunity 56 (12), 2773-2789 (2023)
   PUBMED   37992711
REFERENCE   3  (residues 1 to 279)
  AUTHORS   Ko,B., Yoo,J.Y., Yoo,T., Choi,W., Dogan,R., Sung,K., Um,D.,
            Lee,S.B., Kim,H.J., Lee,S., Beak,S.T., Park,S.K., Paik,S.B.,
            Kim,T.K. and Kim,J.H.
  TITLE     Npas4-mediated dopaminergic regulation of safety memory
            consolidation
  JOURNAL   Cell Rep 42 (7), 112678 (2023)
   PUBMED   37379214
REFERENCE   4  (residues 1 to 279)
  AUTHORS   Haddish,K. and Yun,J.W.
  TITLE     Dopamine receptor D4 (DRD4) negatively regulates UCP1- and
            ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle
            cells
  JOURNAL   Pflugers Arch 475 (6), 757-773 (2023)
   PUBMED   37103560
  REMARK    GeneRIF: Dopamine receptor D4 (DRD4) negatively regulates UCP1- and
            ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle
            cells.
            Erratum:[Pflugers Arch. 2023 Jun;475(6):775. doi:
            10.1007/s00424-023-02819-7. PMID: 37138189]
REFERENCE   5  (residues 1 to 279)
  AUTHORS   Liu,X., Guo,Y., Yang,Y., Qi,C., Xiong,T., Chen,Y., Wu,G., Zeng,C.
            and Wang,D.
  TITLE     DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic Aneurysm via
            Decreasing P38 MAPK (mitogen-activated protein kinase)/NOX4 (NADPH
            Oxidase 4) Axis-Associated Oxidative Stress
  JOURNAL   Hypertension 78 (2), 294-307 (2021)
   PUBMED   34176291
  REMARK    GeneRIF: DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic
            Aneurysm via Decreasing P38 MAPK (mitogen-activated protein
            kinase)/NOX4 (NADPH Oxidase 4) Axis-Associated Oxidative Stress.
REFERENCE   6  (residues 1 to 279)
  AUTHORS   Suzuki,T., Kobayashi,K. and Nagatsu,T.
  TITLE     Genomic structure and tissue distribution of the mouse dopamine D4
            receptor
  JOURNAL   Neurosci Lett 199 (1), 69-72 (1995)
   PUBMED   8584230
REFERENCE   7  (residues 1 to 279)
  AUTHORS   Scott,A.W., Griffin,S.A. and Luedtke,R.R.
  TITLE     Genetic polymorphisms at the rat and murine loci coding for
            dopamine D2-like receptors
  JOURNAL   Brain Res Mol Brain Res 29 (2), 347-357 (1995)
   PUBMED   7609622
REFERENCE   8  (residues 1 to 279)
  AUTHORS   Fishburn,C.S., Carmon,S. and Fuchs,S.
  TITLE     Molecular cloning and characterisation of the gene encoding the
            murine D4 dopamine receptor
  JOURNAL   FEBS Lett 361 (2-3), 215-219 (1995)
   PUBMED   7698326
REFERENCE   9  (residues 1 to 279)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
REFERENCE   10 (residues 1 to 279)
  AUTHORS   Rao,P.A., Pickar,D., Gejman,P.V., Ram,A., Gershon,E.S. and
            Gelernter,J.
  TITLE     Allelic variation in the D4 dopamine receptor (DRD4) gene does not
            predict response to clozapine
  JOURNAL   Arch Gen Psychiatry 51 (11), 912-917 (1994)
   PUBMED   7944879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163434.5.
            
            On Sep 28, 2022 this sequence version replaced XP_017177461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.1420194.1,
                                           SRR17784651.486273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.6 cM"
     Protein         1..279
                     /product="D(4) dopamine receptor isoform 3"
                     /note="d(4) dopamine receptor; d(2C) dopamine receptor;
                     dopamine receptor 4"
                     /calculated_mol_wt=30704
     Region          <1..271
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          1..20
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          41..57
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          77..100
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          205..227
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          239..264
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..279
                     /gene="Drd4"
                     /gene_synonym="D4R; Drd-4"
                     /coded_by="NM_001412326.1:112..951"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:13491"
                     /db_xref="MGI:MGI:94926"
ORIGIN      
        1 mamdvmlcta sifnlcaisv drfvavtvpl rynqqgqcql lliaatwlls aavaspvvcg
       61 lndvpgrdpa vcclenrdyv vyssvcsffl pcplmlllyw atfrglrrwe aarhtklhsr
      121 aprrpsgpgp pvsdptqgpf fpdcppplps lrtspsdssr peselsqrpc spgclladaa
      181 lpqppepssr rrrgakitgr erkamrvlpv vvgaflvcwt pffvvhitra lcpacfvspr
      241 lvsavtwlgy vnsalnpiiy tifnaefrsv frktlrlrc
//
LOCUS       NP_001419110             475 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor EB [Mus musculus].
ACCESSION   NP_001419110
VERSION     NP_001419110.1
DBSOURCE    REFSEQ: accession NM_001432181.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Custode,B.M., Annunziata,F., Dos Santos Matos,F., Schiano,V.,
            Maffia,V., Lillo,M., Colonna,R., De Cegli,R., Ballabio,A. and
            Pastore,N.
  TITLE     Folliculin depletion results in liver cell damage and
            cholangiocarcinoma through MiT/TFE activation
  JOURNAL   Cell Death Differ 32 (8), 1460-1472 (2025)
   PUBMED   40189703
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Kumar,G.V.N., Wang,R.S., Sharma,A.X., David,N.L., Amorim,T.,
            Sinden,D.S., Doshi,N.K., Wabitsch,M., Gingras,S., Ejaz,A.,
            Rubin,J.P., Maron,B.A., Fazeli,P.K. and Steinhauser,M.L.
  TITLE     Non-canonical lysosomal lipolysis drives mobilization of adipose
            tissue energy stores with fasting
  JOURNAL   Nat Commun 16 (1), 1330 (2025)
   PUBMED   39900947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Lei,Q., Chen,X., Xiong,Y., Li,S., Wang,J., He,H. and Deng,Y.
  TITLE     Lysosomal Ca2+ release-facilitated TFEB nuclear translocation
            alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons
  JOURNAL   Sci Rep 14 (1), 24836 (2024)
   PUBMED   39438678
  REMARK    GeneRIF: Lysosomal Ca[2+] release-facilitated TFEB nuclear
            translocation alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124830.8 and AC113536.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3765653.3350869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..475
                     /product="transcription factor EB"
                     /calculated_mol_wt=52483
     Region          1..166
                     /region_name="Interaction with ACSS2.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          4..161
                     /region_name="MITF_TFEB_C_3_N"
                     /note="MITF/TFEB/TFEC/TFE3 N-terminus; pfam15951"
                     /db_xref="CDD:464952"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          135..152
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          155..164
                     /region_name="Strong transcription activation domain.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          225..315
                     /region_name="bHLHzip_TFEB"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in transcription factor EB (TFEB) and similar
                     proteins; cd18927"
                     /db_xref="CDD:381497"
     Site            order(239..240,242..243,246..247,251,272..273)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381497"
     Region          244..247
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            order(249..250,253..254,256,260,273,277..278,281,283..285,
                     287..288,290..291,294,297..299)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381497"
     Region          297..318
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          320..472
                     /region_name="DUF3371"
                     /note="Domain of unknown function (DUF3371); pfam11851"
                     /db_xref="CDD:463372"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          351..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          445..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     CDS             1..475
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /coded_by="NM_001432181.1:48..1475"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
ORIGIN      
        1 masriglrmq lmreqaqqee qrermqqqav mhymqqqqqq qqqlggpptp aintpvhfqs
       61 pppvpgevlk vqsylenpts yhlqqsqhqk vreylsetyg nkfaahvspa qgspkpapaa
      121 spgvraghvl stsagnsapn spmamlhiss npekefddvi dnimrldsvl gyinpemqmp
      181 ntlplssshl nvysgdpqvt asmvgvtsss cpadltqkre ltdaesrala kerqkkdnhn
      241 lierrrrfni ndrikelgml ipkandldvr wnkgtilkas vdyirrmqkd lqksrelenh
      301 srrlemtnkq lwlriqelem qarvhglptt spsgvnmael aqqvvkqelp sedgpgealm
      361 lgpevpepeq mpalppqapl psaaqpqspf hhldfshgls fggggdegpt gypdtlgteh
      421 gspfpnlskk dldlmlldds llplasdplf stmspeaska ssrrssfsme egdvl
//
LOCUS       NP_033829                271 aa            linear   ROD 27-AUG-2025
DEFINITION  aquaporin-2 [Mus musculus].
ACCESSION   NP_033829
VERSION     NP_033829.3
DBSOURCE    REFSEQ: accession NM_009699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 271)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 271)
  AUTHORS   Parvez,R.K., Csipan,R.L., Liu,J., Gevorgyan,A., Rutledge,E.A.,
            Guo,J., Kim,D.K. and McMahon,A.P.
  TITLE     Developmental and Cell Fate Analyses Support a Postnatal Origin for
            the Cortical Collecting System in the Mouse Kidney
  JOURNAL   J Am Soc Nephrol 36 (5), 812-824 (2025)
   PUBMED   39665296
REFERENCE   3  (residues 1 to 271)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 271)
  AUTHORS   Busch,T., Neubauer,B., Schmitt,L., Cascante,I., Knoblich,L.,
            Wegehaupt,O., Scholer,F., Tholen,S., Hofherr,A., Schell,C.,
            Schilling,O., Westermann,L. and Kottgen,M.
  TITLE     The role of the co-chaperone DNAJB11 in polycystic kidney disease:
            Molecular mechanisms and cellular origin of cyst formation
  JOURNAL   FASEB J 38 (21), e70162 (2024)
   PUBMED   39530576
REFERENCE   5  (residues 1 to 271)
  AUTHORS   Ma,Y.S., Deng,S.Q., Zhang,P., Thomsen,J.S., Andreasen,A.,
            Chang,S.J., Zhang,J., Gu,L. and Zhai,X.Y.
  TITLE     Identification of countercurrent tubule-vessel arrangements in the
            early development of mouse kidney based on immunohistochemistry and
            computer-assisted 3D visualization
  JOURNAL   PLoS One 19 (8), e0307223 (2024)
   PUBMED   39137214
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 271)
  AUTHORS   Frokiaer,J., Marples,D., Valtin,H., Morris,J.F., Knepper,M.A. and
            Nielsen,S.
  TITLE     Low aquaporin-2 levels in polyuric DI +/+ severe mice with
            constitutively high cAMP-phosphodiesterase activity
  JOURNAL   Am J Physiol 276 (2), F179-F190 (1999)
   PUBMED   9950948
REFERENCE   7  (residues 1 to 271)
  AUTHORS   Verkman,A.S.
  TITLE     Role of aquaporin water channels in kidney and lung
  JOURNAL   Am J Med Sci 316 (5), 310-320 (1998)
   PUBMED   9822113
  REMARK    Review article
REFERENCE   8  (residues 1 to 271)
  AUTHORS   Knoers,N.V. and Deen,P.M.
  TITLE     Aquaporin molecular biology and clinical abnormalities of the water
            transport channels
  JOURNAL   Curr Opin Pediatr 10 (4), 428-434 (1998)
   PUBMED   9757370
  REMARK    Review article
REFERENCE   9  (residues 1 to 271)
  AUTHORS   Rai,T., Uchida,S., Marumo,F. and Sasaki,S.
  TITLE     Cloning of rat and mouse aquaporin-2 gene promoters and
            identification of a negative cis-regulatory element
  JOURNAL   Am J Physiol 273 (2 Pt 2), F264-F273 (1997)
   PUBMED   9277587
REFERENCE   10 (residues 1 to 271)
  AUTHORS   Horton,C.E. Jr., Davisson,M.T., Jacobs,J.B., Bernstein,G.T.,
            Retik,A.B. and Mandell,J.
  TITLE     Congenital progressive hydronephrosis in mice: a new recessive
            mutation
  JOURNAL   J Urol 140 (5 Pt 2), 1310-1315 (1988)
   PUBMED   3184310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142567.1.
            
            On Nov 16, 2007 this sequence version replaced NP_033829.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142567.1, BM454092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     Protein         1..271
                     /product="aquaporin-2"
                     /note="aquaporin-CD; water channel protein for renal
                     collecting duct; ADH water channel; AQP-2; collecting duct
                     water channel protein"
                     /calculated_mol_wt=28834
     Region          3..219
                     /region_name="MIP"
                     /note="Major intrinsic protein; pfam00230"
                     /db_xref="CDD:395174"
     Site            12..32
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            41..59
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            order(48,66..68,180..181,184,187)
                     /site_type="active"
                     /note="amphipathic channel [active]"
                     /db_xref="CDD:238204"
     Site            order(68..70,184..186)
                     /site_type="other"
                     /note="Asn-Pro-Ala signature motifs"
                     /db_xref="CDD:238204"
     Region          68..70
                     /region_name="NPA 1.
                     /evidence=ECO:0000250|UniProtKB:P41181"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            86..107
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            124
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56402.2)"
     Site            128..148
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            157..176
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Region          184..186
                     /region_name="NPA 2.
                     /evidence=ECO:0000250|UniProtKB:P41181"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            202..222
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Region          251..271
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P56402.2)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16641094,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P56402.2)"
     Site            261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P56402.2)"
     CDS             1..271
                     /gene="Aqp2"
                     /gene_synonym="AQP-CD; cph; jpk; WCH-CD"
                     /coded_by="NM_009699.3:98..913"
                     /db_xref="CCDS:CCDS27822.1"
                     /db_xref="GeneID:11827"
                     /db_xref="MGI:MGI:1096865"
ORIGIN      
        1 mwelrsiafs ravlaeflat llfvffglgs alqwasspps vlqiavafgl gigtlvqalg
       61 hvsgahinpa vtvaclvgch vsflraafyv aaqllgavag aailheitpv eirgdlavna
      121 lhnnatagqa vtvelfltmq lvlcifastd errsdnlgsp alsigfsvtl ghllgiyftg
      181 csmnparsla pavvtgkfdd hwvfwigplv gavigsllyn yllfpstksl qerlavlkgl
      241 epdtdweere vrrrqsvelh spqslprgsk a
//
LOCUS       NP_001074579             247 aa            linear   ROD 27-AUG-2025
DEFINITION  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_001074579 XP_132621
VERSION     NP_001074579.1
DBSOURCE    REFSEQ: accession NM_001081110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 247)
  AUTHORS   Damei,I., Caidi,A., Auclin,E., Adam,J., Mella,S., Hasan,M.,
            Tartour,E., Robert,C., Corgnac,S. and Mami-Chouaib,F.
  TITLE     Different tumour-resident memory T-cell subsets regulate responses
            to anti-PD-1 and anti-CTLA-4 cancer immunotherapies
  JOURNAL   Nat Commun 16 (1), 5588 (2025)
   PUBMED   40593647
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 247)
  AUTHORS   Shimizu,K., Sanpei,A., Nakazato,H., Shinga,J., Ueda,S., Liu,Y.,
            Iyoda,T., Yamasaki,S., Nakabayashi,J. and Fujii,S.I.
  TITLE     Distinct TAM subset with cross-dressing capability determines the
            bifurcation of tumor immunity
  JOURNAL   Cell Rep 44 (6), 115800 (2025)
   PUBMED   40489329
REFERENCE   3  (residues 1 to 247)
  AUTHORS   Schiele,P., Japp,A.S., Stark,R., Sattelberg,J.J., Nikolaou,C.,
            Kornhuber,G., Abbasi,P., Ding,N., Rosnev,S., Meinke,S., Muhle,K.,
            Loyal,L., Braun,J., Dingeldey,M., Durlanik,S., Matzmohr,N.,
            Ponikwicka-Tyszko,D., Wolczynski,S., Rahman,N.A., Taniuchi,I.,
            Schlickeiser,S., Giesecke-Thiel,C., Blankenstein,T., Na,I.K.,
            Thiel,A. and Frentsch,M.
  TITLE     CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in
            CD40-expressing cancer cells
  JOURNAL   Sci Adv 11 (21), eadr9331 (2025)
   PUBMED   40397730
REFERENCE   4  (residues 1 to 247)
  AUTHORS   Li,D., Zhu,J., Zhang,M., Shi,Q., Guo,R., Zhang,D., Zheng,P.,
            Zhang,H., Li,G., Wu,J., Sun,G., Wen,Q., Tan,J., Liu,Z., Liu,X.,
            Yang,H., Lu,H., Cao,G., Yin,Z. and Wang,Q.
  TITLE     SOSTDC1 downregulation in CD4+ T cells confers protection against
            obesity-induced insulin resistance
  JOURNAL   Cell Rep 44 (4), 115496 (2025)
   PUBMED   40173040
REFERENCE   5  (residues 1 to 247)
  AUTHORS   Krstanovic,F., Mihalic,A., Rashidi,A.S., Sitnik,K.M., Ruzsics,Z.,
            Cicin-Sain,L., Verjans,G.M.G.M., Jonjic,S. and Brizic,I.
  TITLE     Neuron-restricted cytomegalovirus latency in the central nervous
            system regulated by CD4+ T-cells and IFN-gamma
  JOURNAL   J Neuroinflammation 22 (1), 95 (2025)
   PUBMED   40158177
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 247)
  AUTHORS   Wallace,V.A., Fung-Leung,W.P., Timms,E., Gray,D., Kishihara,K.,
            Loh,D.Y., Penninger,J. and Mak,T.W.
  TITLE     CD45RA and CD45RBhigh expression induced by thymic selection events
  JOURNAL   J Exp Med 176 (6), 1657-1663 (1992)
   PUBMED   1460424
REFERENCE   7  (residues 1 to 247)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 247)
  AUTHORS   Mak,T.W., Rahemtulla,A., Schilham,M., Koh,D.R. and Fung-Leung,W.P.
  TITLE     Generation of mutant mice lacking surface expression of CD4 or CD8
            by gene targeting
  JOURNAL   J Autoimmun 5 Suppl A, 55-59 (1992)
   PUBMED   1503636
REFERENCE   9  (residues 1 to 247)
  AUTHORS   Gibson,D.M., Taylor,B.A. and Cherry,M.
  TITLE     Evidence for close linkage of a mouse light chain marker with the
            Ly-2,3 locus
  JOURNAL   J Immunol 121 (4), 1585-1590 (1978)
   PUBMED   100557
REFERENCE   10 (residues 1 to 247)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160090.4.
            
            On Feb 6, 2007 this sequence version replaced XP_132621.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M12052.1, AK137937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     Protein         1..247
                     /product="T-cell surface glycoprotein CD8 alpha chain
                     isoform 1 precursor"
                     /note="T-cell surface glycoprotein CD8 alpha chain; CD8
                     antigen, alpha chain; Lyt-2.1 lymphocyte differentiation
                     antigen (AA at 100); T-cell surface glycoprotein Lyt-2"
                     /calculated_mol_wt=24658
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2816
     mat_peptide     28..247
                     /product="T-cell surface glycoprotein CD8 alpha chain.
                     /id=PRO_0000014639"
                     /note="propagated from UniProtKB/Swiss-Prot (P01731.1)"
                     /calculated_mol_wt=24658
     Region          34..147
                     /region_name="IgV_CD8_alpha"
                     /note="Immunoglobulin (Ig)-like variable (V) domain of
                     Cluster of Differentiation (CD) 8 alpha chain; cd05720"
                     /db_xref="CDD:409385"
     Region          34..55
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409385"
     Region          34..38
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409385"
     Region          40..44
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409385"
     Region          46..56
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409385"
     Site            order(47..48,50,52,54)
                     /site_type="other"
                     /note="antibody binding site [polypeptide binding]"
                     /db_xref="CDD:409385"
     Region          56..61
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409385"
     Region          61..68
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409385"
     Region          62..68
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409385"
     Site            order(68,77,135,140..142)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:409385"
     Region          69..94
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409385"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:18929574; propagated from
                     UniProtKB/Swiss-Prot (P01731.1)"
     Site            order(77,79,82,93,132,135,139,142)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409385"
     Region          77..84
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409385"
     Region          89..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409385"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P01731.1)"
     Region          101..133
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409385"
     Region          102..107
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409385"
     Region          111..118
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409385"
     Region          125..133
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409385"
     Region          134..136
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409385"
     Region          136..146
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409385"
     Region          137..147
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409385"
     Site            150
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P01731.1)"
     Region          156..182
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P01731.1)"
     Site            197..217
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P01731.1)"
     CDS             1..247
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /coded_by="NM_001081110.2:127..870"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS39507.1"
                     /db_xref="GeneID:12525"
                     /db_xref="MGI:MGI:88346"
ORIGIN      
        1 maspltrfls lnllllgesi ilgsgeakpq apelrifpkk mdaelgqkvd lvcevlgsvs
       61 qgcswlfqns ssklpqptfv vymasshnki twdeklnssk lfsamrdtnn kyvltlnkfs
      121 kenegyyfcs visnsvmyfs svvpvlqkvn stttkpvlrt pspvhptgts qpqrpedcrp
      181 rgsvkgtgld facdiyiwap lagicvalll sliitlicyh rsrkrvckcp rplvrqegkp
      241 rpsekiv
//
LOCUS       NP_001347190             321 aa            linear   ROD 27-AUG-2025
DEFINITION  dickkopf-related protein 3 isoform c precursor [Mus musculus].
ACCESSION   NP_001347190 XP_006508077
VERSION     NP_001347190.1
DBSOURCE    REFSEQ: accession NM_001360261.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 321)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 321)
  AUTHORS   Song,J., Chen,Y., Chen,Y., Qiu,M., Xiang,W., Ke,B. and Fang,X.
  TITLE     DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner
  JOURNAL   Ren Fail 46 (1), 2343817 (2024)
   PUBMED   38682264
  REMARK    GeneRIF: DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner.
REFERENCE   3  (residues 1 to 321)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 321)
  AUTHORS   Martin Flores,N., Podpolny,M., McLeod,F., Workman,I., Crawford,K.,
            Ivanov,D., Leonenko,G., Escott-Price,V. and Salinas,P.C.
  TITLE     Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model
  JOURNAL   Elife 12, 89453 (2024)
   PUBMED   38285009
  REMARK    GeneRIF: Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 321)
  AUTHORS   Ang,S.J., Stump,R.J., Lovicu,F.J. and McAvoy,J.W.
  TITLE     Spatial and temporal expression of Wnt and Dickkopf genes during
            murine lens development
  JOURNAL   Gene Expr Patterns 4 (3), 289-295 (2004)
   PUBMED   15053977
REFERENCE   7  (residues 1 to 321)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   8  (residues 1 to 321)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (residues 1 to 321)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (residues 1 to 321)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166834.2 and AC122343.4.
            
            On Jan 30, 2018 this sequence version replaced XP_006508077.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence and lacks an alternate in-frame exon compared to
            variant 1. The resulting isoform (c) is shorter at the N-terminus
            and lacks an alternate internal segment compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.81694.1,
                                           SRR1660817.289895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.74 cM"
     Protein         1..321
                     /product="dickkopf-related protein 3 isoform c precursor"
                     /note="dickkopf-related protein 3; dickkopf-3; dickkopf
                     homolog 3"
                     /calculated_mol_wt=33295
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2110
     Region          41..168
                     /region_name="Dkk_Cys1"
                     /note="first cysteine-rich (Cys-1) domain of Dickkopf
                     proteins; cl04692"
                     /db_xref="CDD:471087"
     Region          171..257
                     /region_name="Dkk3_Cys2"
                     /note="second cysteine-rich (Cys-2) domain of
                     Dickkopf-related protein 3; cd23274"
                     /db_xref="CDD:438000"
     CDS             1..321
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /coded_by="NM_001360261.1:190..1155"
                     /note="isoform c precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:50781"
                     /db_xref="MGI:MGI:1354952"
ORIGIN      
        1 mqrlggillc tllaaavpta papsptvtwt paepgpalny pqeeatlnem freveelmed
       61 tqhklrsave emeaeeaaak tssevnlasl ppnyhnetst etrvgnntvh vhqevhkeci
      121 idedcgptry cqfssfkytc qpcrdqqmlc trdseccgdq lcawghctqk atkggngtic
      181 dnqrdcqpgl ccafqrgllf pvctplpveg elchdptsql ldlitwelep egaldrcpca
      241 sgllcqphsh slvymckpaf vgshdhsees qlpreapdey edvgfigevr qeledlersl
      301 aqemafegpa pveslggeee i
//
LOCUS       NP_067272                835 aa            linear   ROD 27-AUG-2025
DEFINITION  toll-like receptor 4 precursor [Mus musculus].
ACCESSION   NP_067272
VERSION     NP_067272.1
DBSOURCE    REFSEQ: accession NM_021297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 835)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 835)
  AUTHORS   Li,C., Adamson,C., Ng,A.W.R., Liang,Y., Hong,Z., Loh,J.T., Ng,S.K.,
            Kwan,J.M.C., Feng,S., Ng,E.W.L., Nair,S., Ruedl,C., Wong,S.H.,
            Lam,K.P. and Qiao,Y.
  TITLE     Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that
            protects the host gut
  JOURNAL   Nat Commun 16 (1), 5577 (2025)
   PUBMED   40593577
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 835)
  AUTHORS   Takahashi,T., Asano,Y., Ichimura,Y., Toyama,T., Taniguchi,T.,
            Noda,S., Akamata,K., Tada,Y., Sugaya,M., Kadono,T. and Sato,S.
  TITLE     Amelioration of tissue fibrosis by toll-like receptor 4 knockout in
            murine models of systemic sclerosis
  JOURNAL   Arthritis Rheumatol 67 (1), 254-265 (2015)
   PUBMED   25302613
  REMARK    GeneRIF: There is a pivotal contribution of TLR-4 to the pathologic
            tissue fibrosis of systemic sclerosis murine models.
REFERENCE   4  (residues 1 to 835)
  AUTHORS   Jialal,I., Major,A.M. and Devaraj,S.
  TITLE     Global Toll-like receptor 4 knockout results in decreased renal
            inflammation, fibrosis and podocytopathy
  JOURNAL   J Diabetes Complications 28 (6), 755-761 (2014)
   PUBMED   25116192
  REMARK    GeneRIF: Global genetic deficiency of TLR4 also ameliorates renal
            inflammation, fibrosis and podocytopathy and could be important in
            diabetic nephropathy.
REFERENCE   5  (residues 1 to 835)
  AUTHORS   Zanoni,I., Ostuni,R., Marek,L.R., Barresi,S., Barbalat,R.,
            Barton,G.M., Granucci,F. and Kagan,J.C.
  TITLE     CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
  JOURNAL   Cell 147 (4), 868-880 (2011)
   PUBMED   22078883
  REMARK    GeneRIF: These data establish that upon microbial detection, an
            upstream Pattern Recognition Receptor, CD14 controls the
            trafficking and signaling functions of a downstream Pattern
            Recognition Receptor, TLR4.
REFERENCE   6  (residues 1 to 835)
  AUTHORS   West,A.P., Brodsky,I.E., Rahner,C., Woo,D.K., Erdjument-Bromage,H.,
            Tempst,P., Walsh,M.C., Choi,Y., Shadel,G.S. and Ghosh,S.
  TITLE     TLR signalling augments macrophage bactericidal activity through
            mitochondrial ROS
  JOURNAL   Nature 472 (7344), 476-480 (2011)
   PUBMED   21525932
REFERENCE   7  (residues 1 to 835)
  AUTHORS   Kim,H.M., Park,B.S., Kim,J.I., Kim,S.E., Lee,J., Oh,S.C.,
            Enkhbayar,P., Matsushima,N., Lee,H., Yoo,O.J. and Lee,J.O.
  TITLE     Crystal structure of the TLR4-MD-2 complex with bound endotoxin
            antagonist Eritoran
  JOURNAL   Cell 130 (5), 906-917 (2007)
   PUBMED   17803912
  REMARK    GeneRIF: Based on structural analysis and mutagenesis experiments
            on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization
            induced by LPS.
REFERENCE   8  (residues 1 to 835)
  AUTHORS   Foster,S.L., Hargreaves,D.C. and Medzhitov,R.
  TITLE     Gene-specific control of inflammation by TLR-induced chromatin
            modifications
  JOURNAL   Nature 447 (7147), 972-978 (2007)
   PUBMED   17538624
  REMARK    GeneRIF: Using an in vitro system of lipopolysaccharide tolerance
            in murine macrophages, we show that TLR-induced genes fall into two
            categories on the basis of their functions and regulatory
            requirements
            Erratum:[Nature. 2008 Jan 3;451(7174):102]
REFERENCE   9  (residues 1 to 835)
  AUTHORS   Rosenstreich,D.L., Vogel,S.N., Jacques,A.R., Wahl,L.M. and
            Oppenheim,J.J.
  TITLE     Macrophage sensitivity to endotoxin: genetic control by a single
            codominant gene
  JOURNAL   J Immunol 121 (5), 1664-1670 (1978)
   PUBMED   101590
REFERENCE   10 (residues 1 to 835)
  AUTHORS   Watson,J. and Riblet,R.
  TITLE     Genetic control of responses to bacterial lipopolysaccharides in
            mice. II. A gene that influences a membrane component involved in
            the activation of bone marrow-derived lymphocytes by
            lipipolysaccharides
  JOURNAL   J Immunol 114 (5), 1462-1468 (1975)
   PUBMED   123543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX649609.2, CD544295.1,
            JX878359.1, AK030348.1, AI450864.1 and BX514079.1.
            
            Summary: This gene belongs to the evolutionarily-conserved
            Toll-like receptor family, whose members are type-1 transmembrane
            proteins that are involved in innate immunity. Toll-like receptors
            are characterized by an extracellular leucine-rich repeat domain
            that functions in ligand recognition and an intracellular
            toll/interleukin-1 receptor-like domain that is crucial for signal
            transduction. The receptor encoded by this gene mediates the innate
            immune response to bacterial lipopolysaccharide, a major component
            of the outer membrane of Gram-negative bacteria, through synthesis
            of pro-inflammatory cytokines and chemokines. In addition, this
            protein can recognize other pathogens from Gram-negative and
            Gram-positive bacteria as well as viral components. Mice deficient
            in this gene display a number of immune response-related phenotypes
            including hyporesponsiveness to bacterial lipopolysaccharide and
            increased levels of respiratory syncytial virus compared to
            controls. [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030348.1, AF110133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.66 cM"
     Protein         1..835
                     /product="toll-like receptor 4 precursor"
                     /EC_number="3.2.2.6"
                     /note="lipopolysaccharide response; Toll like receptor 4"
                     /calculated_mol_wt=92727
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2811
     mat_peptide     26..835
                     /product="Toll-like receptor 4. /id=PRO_0000034723"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
                     /calculated_mol_wt=92727
     Site            34
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          <53..298
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          54..75
                     /region_name="LRR 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          58..78
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            75
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          78..99
                     /region_name="LRR 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          79..102
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..123
                     /region_name="LRR 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          103..126
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..147
                     /region_name="LRR 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          127..150
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..171
                     /region_name="LRR 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          151..175
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            172
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          175..198
                     /region_name="LRR 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          176..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          204..224
                     /region_name="LRR 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          205..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          226..247
                     /region_name="LRR 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            237
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          248..269
                     /region_name="LRR 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            307
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          329..349
                     /region_name="LRR 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          331..350
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <347..>580
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          350..370
                     /region_name="LRR 11. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          351..372
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          372..392
                     /region_name="LRR 12. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          373..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          398..420
                     /region_name="LRR 13. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          399..421
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..442
                     /region_name="LRR 14. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          422..446
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          446..467
                     /region_name="LRR 15. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          447..470
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          470..490
                     /region_name="LRR 16. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          471..495
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            492
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          495..516
                     /region_name="LRR 17. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            495
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          496..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          519..540
                     /region_name="LRR 18. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          520..543
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          543..564
                     /region_name="LRR 19. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            572
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17803912; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            575
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            613
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            621
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            622
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Site            639..659
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          670..835
                     /region_name="Interaction with SCIMP.
                     /evidence=ECO:0000269|PubMed:28098138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QUK6.1)"
     Region          672..813
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..835
                     /gene="Tlr4"
                     /gene_synonym="Lps; Ly87; Ran/M1; Rasl2-8"
                     /coded_by="NM_021297.3:282..2789"
                     /db_xref="CCDS:CCDS18271.1"
                     /db_xref="GeneID:21898"
                     /db_xref="MGI:MGI:96824"
ORIGIN      
        1 mmppwllart limalffscl tpgslnpcie vvpnityqcm dqklskvpdd ipsstknidl
       61 sfnplkilks ysfsnfselq wldlsrceie tiedkawhgl hhlsnliltg npiqsfspgs
      121 fsgltslenl vavetklasl esfpigqlit lkklnvahnf ihscklpayf snltnlvhvd
      181 lsynyiqtit vndlqflren pqvnlsldms lnpidfiqdq afqgiklhel tlrgnfnssn
      241 imktclqnla glhvhrlilg efkdernlei fepsimeglc dvtidefrlt ytndfsddiv
      301 kfhclanvsa mslagvsiky ledvpkhfkw qslsiircql kqfptldlpf lksltltmnk
      361 gsisfkkval pslsyldlsr nalsfsgccs ysdlgtnslr hldlsfngai imsanfmgle
      421 elqhldfqhs tlkrvtefsa flslekllyl disytntkid fdgiflglts lntlkmagns
      481 fkdntlsnvf anttnltfld lskcqleqis wgvfdtlhrl qllnmshnnl lfldsshynq
      541 lyslstldcs fnrietskgi lqhfpkslaf fnltnnsvac icehqkflqw vkeqkqflvn
      601 veqmtcatpv emntslvldf nnstcymykt iisvsvvsvi vvstvafliy hfyfhlilia
      661 gckkysrges iydafviyss qnedwvrnel vknleegvpr fhlclhyrdf ipgvaiaani
      721 iqegfhksrk vivvvsrhfi qsrwcifeye iaqtwqflss rsgiifivle kveksllrqq
      781 velyrllsrn tylewednpl grhifwrrlk nalldgkasn peqtaeeeqe tatwt
//
LOCUS       NP_034959               1095 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA mismatch repair protein Msh3 isoform 1 [Mus musculus].
ACCESSION   NP_034959 XP_918213 XP_927742 XP_927747 XP_927752 XP_927755
            XP_927761 XP_927765 XP_927770 XP_927774
VERSION     NP_034959.2
DBSOURCE    REFSEQ: accession NM_010829.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1095)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell 188 (6), 1524-1544 (2025)
   PUBMED   39938516
REFERENCE   2  (residues 1 to 1095)
  AUTHORS   Bunting,E.L., Donaldson,J., Cumming,S.A., Olive,J., Broom,E.,
            Miclaus,M., Hamilton,J., Tegtmeyer,M., Zhao,H.T., Brenton,J.,
            Lee,W.S., Handsaker,R.E., Li,S., Ford,B., Ryten,M., McCarroll,S.A.,
            Kordasiewicz,H.B., Monckton,D.G., Balmus,G., Flower,M. and
            Tabrizi,S.J.
  TITLE     Antisense oligonucleotide-mediated MSH3 suppression reduces somatic
            CAG repeat expansion in Huntington's disease iPSC-derived striatal
            neurons
  JOURNAL   Sci Transl Med 17 (785), eadn4600 (2025)
   PUBMED   39937881
REFERENCE   3  (residues 1 to 1095)
  AUTHORS   Aldous,S.G., Smith,E.J., Landles,C., Osborne,G.F.,
            Canibano-Pico,M., Nita,I.M., Phillips,J., Zhang,Y., Jin,B.,
            Hirst,M.B., Benn,C.L., Bond,B.C., Edelmann,W., Greene,J.R. and
            Bates,G.P.
  TITLE     A CAG repeat threshold for therapeutics targeting somatic
            instability in Huntington's disease
  JOURNAL   Brain 147 (5), 1784-1798 (2024)
   PUBMED   38387080
REFERENCE   4  (residues 1 to 1095)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 1095)
  AUTHORS   Driscoll,R., Hampton,L., Abraham,N.A., Larigan,J.D., Joseph,N.F.,
            Hernandez-Vega,J.C., Geisler,S., Yang,F.C., Deninger,M., Tran,D.T.,
            Khatri,N., Godinho,B.M.D.C., Kinberger,G.A., Montagna,D.R.,
            Hirst,W.D., Guardado,C.L., Glajch,K.E., Arnold,H.M.,
            Gallant-Behm,C.L. and Weihofen,A.
  TITLE     Dose-dependent reduction of somatic expansions but not Htt
            aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111
            mice
  JOURNAL   Sci Rep 14 (1), 2061 (2024)
   PUBMED   38267530
  REMARK    GeneRIF: Dose-dependent reduction of somatic expansions but not Htt
            aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111
            mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1095)
  AUTHORS   Liu,K., Niu,L., Linton,J.P. and Crouse,G.F.
  TITLE     Characterization of the mouse Rep-3 gene: sequence similarities to
            bacterial and yeast mismatch-repair proteins
  JOURNAL   Gene 147 (2), 169-177 (1994)
   PUBMED   7926796
REFERENCE   7  (residues 1 to 1095)
  AUTHORS   Smith,M.L., Mitchell,P.J. and Crouse,G.F.
  TITLE     Analysis of the mouse Dhfr/Rep-3 major promoter region by using
            linker-scanning and internal deletion mutations and DNase I
            footprinting
  JOURNAL   Mol Cell Biol 10 (11), 6003-6012 (1990)
   PUBMED   2233729
REFERENCE   8  (residues 1 to 1095)
  AUTHORS   Linton,J.P., Yen,J.Y., Selby,E., Chen,Z., Chinsky,J.M., Liu,K.,
            Kellems,R.E. and Crouse,G.F.
  TITLE     Dual bidirectional promoters at the mouse dhfr locus: cloning and
            characterization of two mRNA classes of the divergently transcribed
            Rep-1 gene
  JOURNAL   Mol Cell Biol 9 (7), 3058-3072 (1989)
   PUBMED   2674679
REFERENCE   9  (residues 1 to 1095)
  AUTHORS   Fujii,H. and Shimada,T.
  TITLE     Isolation and characterization of cDNA clones derived from the
            divergently transcribed gene in the region upstream from the human
            dihydrofolate reductase gene
  JOURNAL   J Biol Chem 264 (17), 10057-10064 (1989)
   PUBMED   2722860
REFERENCE   10 (residues 1 to 1095)
  AUTHORS   McGrogan,M., Simonsen,C.C., Smouse,D.T., Farnham,P.J. and
            Schimke,R.T.
  TITLE     Heterogeneity at the 5' termini of mouse dihydrofolate reductase
            mRNAs. Evidence for multiple promoter regions
  JOURNAL   J Biol Chem 260 (4), 2307-2314 (1985)
   PUBMED   2982814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161588.2 and AC155263.2.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_918213.1, XP_927742.1, XP_927747.1, XP_927752.1, XP_927755.1,
            XP_927761.1, XP_927765.1, XP_927770.1, XP_927774.1, NP_034959.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133907.1, AK161089.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.63 cM"
     Protein         1..1095
                     /product="DNA mismatch repair protein Msh3 isoform 1"
                     /note="DNA mismatch repair protein Msh3; protein repair-1;
                     protein repair-3"
                     /calculated_mol_wt=123274
     Region          1..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P13705.3)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P20585; propagated from
                     UniProtKB/Swiss-Prot (P13705.3)"
     Region          183..1052
                     /region_name="MutS"
                     /note="DNA mismatch repair ATPase MutS [Replication,
                     recombination and repair]; COG0249"
                     /db_xref="CDD:440019"
     CDS             1..1095
                     /gene="Msh3"
                     /gene_synonym="D13Em1; REP-1; Rep-3; Rep3"
                     /coded_by="NM_010829.3:108..3395"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49326.1"
                     /db_xref="GeneID:17686"
                     /db_xref="MGI:MGI:109519"
ORIGIN      
        1 mprgksasgg staagpgpgr qtvlsrffrs agslrssass tepaekvteg dsrkrslgng
       61 gptkkkarkv pekeeenisv aahhpeakkc lrprivlksl eklkefccds alpqnrvqte
      121 alrerlevlp rctdfeditl qraknavlse dsksqanqkd sqfgpcpevf qktsdckpfn
      181 krsksvytpl elqyldmkqq hkdavlcvec gykyrffged aeiaarelni ychldhnfmt
      241 asipthrlfv hvrrlvakgy kvgvvkqtet aalkaigdnk ssvfsrklta lytkstlige
      301 dvnplirldd svnidevmtd tstnyllciy eekenikdkk kgnlsvgivg vqpatgevvf
      361 dcfqdsasrl eletrisslq pvelllpsdl svptemliqr atnvsvrddr irvermnnty
      421 feyshafqtv tefyareivd sqgsqslsgv inlekpvica laavirylke fnlekmlskp
      481 esfkqlssgm efmringttl rnleilqnqt dmktkgsllw vldhtktsfg rrklknwvtq
      541 pllklreina rldavsdvlh sessvfeqie nllrklpdve rglcsiyhkk cstqeffliv
      601 kslcqlksel qalmpavnsh vqsdllrali veapellspv ehylkvlngp aakvgdktel
      661 fkdlsdfpli kkrkneiqev ihsiqmrlqe frkilklpsl qyvtvsgqef mieiknsavs
      721 cipadwvkvg stkavsrfhp pfivesyrrl nqlreqlvld cnaewlgfle nfgehyhtlc
      781 kavdhlatvd cifslakvak qgnycrptlq eekkiiikng rhpmidvllg eqdqfvpnst
      841 slsqdservm iitgpnmggk ssyikqvalv timaqigsyv paeeatigiv dgiftrmgaa
      901 dniykgrstf meeltdtaei irraspqslv ildelgrgts thdgiaiaya tleyfirdvk
      961 sltlfvthyp pvcelekcyp eqvgnyhmgf lvnedeskqd sgdmeqmpds vtflyqitrg
     1021 iaarsyglnv akladvprev lqkaahkske leglvslrrk rlecftdlwt thsvkdlhtw
     1081 adklemeeiq tslph
//
LOCUS       NP_035679                475 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor EB [Mus musculus].
ACCESSION   NP_035679
VERSION     NP_035679.4
DBSOURCE    REFSEQ: accession NM_011549.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Custode,B.M., Annunziata,F., Dos Santos Matos,F., Schiano,V.,
            Maffia,V., Lillo,M., Colonna,R., De Cegli,R., Ballabio,A. and
            Pastore,N.
  TITLE     Folliculin depletion results in liver cell damage and
            cholangiocarcinoma through MiT/TFE activation
  JOURNAL   Cell Death Differ 32 (8), 1460-1472 (2025)
   PUBMED   40189703
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Kumar,G.V.N., Wang,R.S., Sharma,A.X., David,N.L., Amorim,T.,
            Sinden,D.S., Doshi,N.K., Wabitsch,M., Gingras,S., Ejaz,A.,
            Rubin,J.P., Maron,B.A., Fazeli,P.K. and Steinhauser,M.L.
  TITLE     Non-canonical lysosomal lipolysis drives mobilization of adipose
            tissue energy stores with fasting
  JOURNAL   Nat Commun 16 (1), 1330 (2025)
   PUBMED   39900947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Lei,Q., Chen,X., Xiong,Y., Li,S., Wang,J., He,H. and Deng,Y.
  TITLE     Lysosomal Ca2+ release-facilitated TFEB nuclear translocation
            alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons
  JOURNAL   Sci Rep 14 (1), 24836 (2024)
   PUBMED   39438678
  REMARK    GeneRIF: Lysosomal Ca[2+] release-facilitated TFEB nuclear
            translocation alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113536.10.
            
            On Jul 27, 2024 this sequence version replaced NP_035679.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064789.1, AK146016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..475
                     /product="transcription factor EB"
                     /calculated_mol_wt=52483
     Region          1..166
                     /region_name="Interaction with ACSS2.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          4..161
                     /region_name="MITF_TFEB_C_3_N"
                     /note="MITF/TFEB/TFEC/TFE3 N-terminus; pfam15951"
                     /db_xref="CDD:464952"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          135..152
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          155..164
                     /region_name="Strong transcription activation domain.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          225..315
                     /region_name="bHLHzip_TFEB"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in transcription factor EB (TFEB) and similar
                     proteins; cd18927"
                     /db_xref="CDD:381497"
     Site            order(239..240,242..243,246..247,251,272..273)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381497"
     Region          244..247
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            order(249..250,253..254,256,260,273,277..278,281,283..285,
                     287..288,290..291,294,297..299)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381497"
     Region          297..318
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          320..472
                     /region_name="DUF3371"
                     /note="Domain of unknown function (DUF3371); pfam11851"
                     /db_xref="CDD:463372"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          351..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          445..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     CDS             1..475
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /coded_by="NM_011549.4:273..1700"
                     /db_xref="CCDS:CCDS28856.1"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
ORIGIN      
        1 masriglrmq lmreqaqqee qrermqqqav mhymqqqqqq qqqlggpptp aintpvhfqs
       61 pppvpgevlk vqsylenpts yhlqqsqhqk vreylsetyg nkfaahvspa qgspkpapaa
      121 spgvraghvl stsagnsapn spmamlhiss npekefddvi dnimrldsvl gyinpemqmp
      181 ntlplssshl nvysgdpqvt asmvgvtsss cpadltqkre ltdaesrala kerqkkdnhn
      241 lierrrrfni ndrikelgml ipkandldvr wnkgtilkas vdyirrmqkd lqksrelenh
      301 srrlemtnkq lwlriqelem qarvhglptt spsgvnmael aqqvvkqelp sedgpgealm
      361 lgpevpepeq mpalppqapl psaaqpqspf hhldfshgls fggggdegpt gypdtlgteh
      421 gspfpnlskk dldlmlldds llplasdplf stmspeaska ssrrssfsme egdvl
//
LOCUS       NP_001333651            1195 aa            linear   ROD 27-AUG-2025
DEFINITION  protocadherin-9 isoform e precursor [Mus musculus].
ACCESSION   NP_001333651 XP_006518838
VERSION     NP_001333651.1
DBSOURCE    REFSEQ: accession NM_001346722.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1195)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1195)
  AUTHORS   Miozzo,F., Murru,L., Maiellano,G., di Iasio,I., Zippo,A.G.,
            Zambrano Avendano,A., Metodieva,V.D., Riccardi,S., D'Aliberti,D.,
            Spinelli,S., Canu,T., Chaabane,L., Hirano,S., Kas,M.J.H.,
            Francolini,M., Piazza,R., Moretto,E. and Passafaro,M.
  TITLE     Disruption of the autism-associated Pcdh9 gene leads to
            transcriptional alterations, synapse overgrowth, and defective
            network activity in the CA1
  JOURNAL   J Neurosci 44 (50) (2024) In press
   PUBMED   39557582
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1195)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1195)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (residues 1 to 1195)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   6  (residues 1 to 1195)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   7  (residues 1 to 1195)
  AUTHORS   Krishna-K,K., Hertel,N. and Redies,C.
  TITLE     Cadherin expression in the somatosensory cortex: evidence for a
            combinatorial molecular code at the single-cell level
  JOURNAL   Neuroscience 175, 37-48 (2011)
   PUBMED   21129452
REFERENCE   8  (residues 1 to 1195)
  AUTHORS   Vanhalst,K., Kools,P., Staes,K., van Roy,F. and Redies,C.
  TITLE     delta-Protocadherins: a gene family expressed differentially in the
            mouse brain
  JOURNAL   Cell Mol Life Sci 62 (11), 1247-1259 (2005)
   PUBMED   15905963
REFERENCE   9  (residues 1 to 1195)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   10 (residues 1 to 1195)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC132470.3, AC122355.4,
            AC125095.3 and AC123919.4.
            
            On Oct 27, 2016 this sequence version replaced XP_006518838.1.
            
            Summary: This gene encodes a member of the protocadherin family,
            and cadherin superfamily, of transmembrane proteins containing
            cadherin domains. These proteins mediate cell adhesion in neural
            tissues in the presence of calcium. The encoded protein may be
            involved in signaling at neuronal synaptic junctions. Sharing a
            characteristic with other protocadherin genes, this gene has a
            notably large exon that encodes multiple cadherin domains and a
            transmembrane region. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Nov 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.284462.1,
                                           SRR1660825.68801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849385 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1195
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 45.8 cM"
     Protein         1..1195
                     /product="protocadherin-9 isoform e precursor"
                     /calculated_mol_wt=129171
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2568
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1195
                     /gene="Pcdh9"
                     /coded_by="NM_001346722.1:716..4303"
                     /note="isoform e precursor is encoded by transcript
                     variant 5"
                     /db_xref="CCDS:CCDS84156.1"
                     /db_xref="GeneID:211712"
                     /db_xref="MGI:MGI:1306801"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf nreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtded
      601 agenkavtls ilndnenfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdidtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkalhtlvlv flyvndtagn
      781 tsyiydlirr tmetpldrni gdsgqpyqne dyltimiaiv agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqgigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqcnsysknd
     1021 nipvthqkcp gstsfhiren eeshsepqde fydqaspdkr teadgnsdpn sdgplgprgl
     1081 aeatemctqe clvlghsdnc wmppglgpyq hpksplstfa pqkewikkdk lvnghtltra
     1141 wkedtnrnqf ndrkqygsne ghfnngghma diplanlksy kqaggtiesp kehql
//
LOCUS       NP_033908               1663 aa            linear   ROD 27-AUG-2025
DEFINITION  complement C3 preproprotein [Mus musculus].
ACCESSION   NP_033908
VERSION     NP_033908.2
DBSOURCE    REFSEQ: accession NM_009778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1663)
  AUTHORS   Jagnarine,S., Qiu,A., Kyritsis,E., Dei Zotti,F. and Hudson,K.E.
  TITLE     IgG2b enhances alloantibodies to stored red blood cells
  JOURNAL   Transfusion 65 (8), 1408-1417 (2025)
   PUBMED   40485608
REFERENCE   2  (residues 1 to 1663)
  AUTHORS   Kageyama,M., Ohashi,K. and Ota,T.
  TITLE     Functional significance of commonly regulated genes in mechanically
            and chemically induced retinal ganglion cell death in rat eyes
  JOURNAL   Sci Rep 15 (1), 23681 (2025)
   PUBMED   40604065
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1663)
  AUTHORS   Tian,Y., Lucena-Cacace,A., Tani,K., Elvandari,A.P., Allendes
            Osorio,R.S., Narita,M., Matsumura,Y., Paixao,I.C., Miyoshi,Y.,
            Inagaki,A., Junghof,J. and Yoshida,Y.
  TITLE     Generation of mature epicardium derived from human-induced
            pluripotent stem cells via inhibition of mTOR signaling
  JOURNAL   Nat Commun 16 (1), 5902 (2025)
   PUBMED   40593704
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1663)
  AUTHORS   Chen,R., Powell,J.S., Shufesky,W.J., Bardhi,E., Sullivan,M.L.G.,
            Tkacheva,O.A., Camirand,G., Goncalves,Z., Stolz,D.B., Chalasani,G.,
            Catz,S.D., Watkins,S.C., Larregina,A.T. and Morelli,A.E.
  TITLE     Transplants foster B cell alloimmunity by relaying extracellular
            vesicles to follicular dendritic cells
  JOURNAL   Cell Rep 44 (6), 115832 (2025)
   PUBMED   40516053
REFERENCE   5  (residues 1 to 1663)
  AUTHORS   Paglialunga,S., Fisette,A., Yan,Y., Deshaies,Y., Brouillette,J.F.,
            Pekna,M. and Cianflone,K.
  TITLE     Acylation-stimulating protein deficiency and altered adipose tissue
            in alternative complement pathway knockout mice
  JOURNAL   Am J Physiol Endocrinol Metab 294 (3), E521-E529 (2008)
   PUBMED   18160458
  REMARK    GeneRIF: reduction/deficiency in acylation stimulating protein
            (ASP) is associated with an antiadipogenic state and ASP may
            provide a target for controlling fat storage
REFERENCE   6  (residues 1 to 1663)
  AUTHORS   Sahu,A. and Lambris,J.D.
  TITLE     Structure and biology of complement protein C3, a connecting link
            between innate and acquired immunity
  JOURNAL   Immunol Rev 180, 35-48 (2001)
   PUBMED   11414361
  REMARK    Review article
REFERENCE   7  (residues 1 to 1663)
  AUTHORS   Fey,G., Domdey,H., Wiebauer,K., Whitehead,A.S. and Odink,K.
  TITLE     Structure and expression of the C3 gene
  JOURNAL   Springer Semin Immunopathol 6 (2-3), 119-147 (1983)
   PUBMED   6356427
  REMARK    Review article
REFERENCE   8  (residues 1 to 1663)
  AUTHORS   Rubinstein,P., Vienne,K. and Hoecker,G.F.
  TITLE     The location of the C3 and GLO (glyoxalase 1) loci of the IXth
            linkage group in mice
  JOURNAL   J Immunol 122 (6), 2584-2589 (1979)
   PUBMED   448134
REFERENCE   9  (residues 1 to 1663)
  AUTHORS   Natsuume-Sakai,S., Amano,S., Hayakawa,J.I. and Takahashi,M.
  TITLE     Preparation of an alloantiserum to murine C3 and demonstration of
            multiple alleles
  JOURNAL   J Immunol 121 (5), 2025-2029 (1978)
   PUBMED   101594
REFERENCE   10 (residues 1 to 1663)
  AUTHORS   Da Silva,F.P., Hoecker,G.F., Day,N.K., Vienne,K. and Rubinstein,P.
  TITLE     Murine complement component 3: genetic variation and linkage to H-2
  JOURNAL   Proc Natl Acad Sci U S A 75 (2), 963-965 (1978)
   PUBMED   273258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025692.15.
            
            On Mar 2, 2007 this sequence version replaced NP_033908.1.
            
            Summary: This gene encodes complement protein C3 which plays a
            central role in the classical, alternative and lectin activation
            pathways of the complement system. The encoded preproprotein
            undergoes a multi-step processing to generate various functional
            peptides. Mice deficient in the encoded protein fail to clear
            bacteria from the blood stream upon infection, display diminished
            airway hyperresponsiveness and lung eosinophilia upon
            allergen-induced pulmonary allergy, and develop severe lung injury
            after deposition of IgG immune complexes. Deficiency of the homolog
            of the encoded protein in humans was found to be associated with
            increased susceptibility to infections, age-related macular
            degeneration, and atypical hemolytic uremic syndrome. [provided by
            RefSeq, Mar 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043338.1, K02782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.72 cM"
     Protein         1..1663
                     /product="complement C3 preproprotein"
                     /EC_number="3.4.21.43"
                     /note="complement C3; complement component 3d; complement
                     factor 3; acylation stimulating protein"
                     /calculated_mol_wt=184181
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2322
     mat_peptide     25..1663
                     /product="Complement C3. /id=PRO_0000005917"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=184181
     mat_peptide     25..666
                     /product="Complement C3 beta chain. /id=PRO_0000005918"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=70640
     Region          26..125
                     /region_name="MG1"
                     /note="Macroglobulin domain MG1; pfam17790"
                     /db_xref="CDD:465508"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Region          130..225
                     /region_name="MG2"
                     /note="MG2 domain; pfam01835"
                     /db_xref="CDD:426464"
     Region          227..308
                     /region_name="MG3"
                     /note="Macroglobulin domain MG3; pfam17791"
                     /db_xref="CDD:465509"
     Region          356..446
                     /region_name="MG4"
                     /note="Macroglobulin domain MG4; pfam17789"
                     /db_xref="CDD:465507"
     Region          456..604
                     /region_name="A2M_BRD"
                     /note="Alpha-2-macroglobulin bait region domain;
                     pfam07703"
                     /db_xref="CDD:462235"
     mat_peptide     569..666
                     /product="C3-beta-c.
                     /evidence=ECO:0000250|UniProtKB:P01026.
                     /id=PRO_0000430431"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=10470
     mat_peptide     671..1663
                     /product="Complement C3 alpha chain. /id=PRO_0000005919"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=112934
     mat_peptide     671..748
                     /product="C3a anaphylatoxin. /id=PRO_0000005920"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=9225
     mat_peptide     671..747
                     /product="Acylation stimulating protein.
                     /id=PRO_0000419936"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=9069
     Site            671
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Region          678..747
                     /region_name="ANATO"
                     /note="Anaphylatoxin homologous domain; C3a, C4a and C5a
                     anaphylatoxins are protein fragments generated
                     enzymatically in serum during activation of complement
                     molecules C3, C4, and C5. They induce smooth muscle
                     contraction. These fragments are homologous to...;
                     cd00017"
                     /db_xref="CDD:237984"
     Site            747..748
                     /site_type="cleavage"
                     /note="Cleavage, by carboxypeptidases.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Site            748..749
                     /site_type="cleavage"
                     /note="Cleavage, by C3 convertase.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     mat_peptide     749..1663
                     /product="Complement C3b. /id=PRO_0000005921"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=103727
     mat_peptide     749..954
                     /product="Complement C3c alpha' chain fragment 1.
                     /id=PRO_0000005922"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=23683
     Region          770..866
                     /region_name="A2M"
                     /note="Alpha-2-macroglobulin family; pfam00207"
                     /db_xref="CDD:459711"
     Site            939
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Site            954..955
                     /site_type="cleavage"
                     /note="Cleavage, by factor I. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P01027.3)"
     mat_peptide     955..1303
                     /product="Complement C3dg fragment. /id=PRO_0000005923"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=38820
     mat_peptide     955..1001
                     /product="Complement C3g fragment. /id=PRO_0000005924"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=4950
     Site            968
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Region          996..1282
                     /region_name="complement_C3_C4_C5"
                     /note="Proteins similar to C3, C4 and C5 of vertebrate
                     complement. The vertebrate complement system, comprised of
                     a large number of distinct plasma proteins, is an effector
                     of both the acquired and innate immune systems. The point
                     of convergence of the...; cd02896"
                     /db_xref="CDD:239226"
     mat_peptide     1002..1303
                     /product="Complement C3d fragment. /id=PRO_0000005925"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=33888
     Site            order(1010,1012..1013,1016,1059,1069,1072,1123,1125..1126,
                     1266)
                     /site_type="other"
                     /note="surface patch"
                     /db_xref="CDD:239226"
     Site            order(1010..1013,1126)
                     /site_type="active"
                     /db_xref="CDD:239226"
     Site            1010..1013
                     /site_type="active"
                     /note="thioester region [active]"
                     /db_xref="CDD:239226"
     Site            order(1112,1116,1118,1126,1131..1132)
                     /site_type="other"
                     /note="specificity defining residues"
                     /db_xref="CDD:239226"
     Site            1303..1304
                     /site_type="cleavage"
                     /note="Cleavage, by factor I.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     mat_peptide     1304..1320
                     /product="Complement C3f fragment. /id=PRO_0000005927"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=1978
     Site            1320..1321
                     /site_type="cleavage"
                     /note="Cleavage, by factor I.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     mat_peptide     1321..1663
                     /product="Complement C3c alpha' chain fragment 2.
                     /id=PRO_0000273949"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
                     /calculated_mol_wt=39300
     Site            1321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Region          1397..1494
                     /region_name="A2M_recep"
                     /note="A-macroglobulin receptor binding domain; pfam07677"
                     /db_xref="CDD:462226"
     Region          1513..1661
                     /region_name="NTR_complement_C3"
                     /note="NTR/C345C domain, complement C3 subfamily; The NTR
                     domain found in complement C3 is also known as the C345C
                     domain because it occurs at the C-terminus of complement
                     C3, C4 and C5. Complement C3 plays a pivotal role in the
                     activation of the complement...; cd03583"
                     /db_xref="CDD:239638"
     Site            1573
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Site            1617
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     Region          1634..1659
                     /region_name="Interaction with CFP/properdin.
                     /evidence=ECO:0000250|UniProtKB:P01024"
                     /note="propagated from UniProtKB/Swiss-Prot (P01027.3)"
     Site            1663
                     /site_type="other"
                     /note="Coordinates Mg(2+) for interaction with Complement
                     factor B Bb fragment (CFB).
                     /evidence=ECO:0000250|UniProtKB:P01024; propagated from
                     UniProtKB/Swiss-Prot (P01027.3)"
     CDS             1..1663
                     /gene="C3"
                     /gene_synonym="ASP; HSE-MSF; Plp"
                     /coded_by="NM_009778.3:102..5093"
                     /db_xref="CCDS:CCDS37670.1"
                     /db_xref="GeneID:12266"
                     /db_xref="MGI:MGI:88227"
ORIGIN      
        1 mgpasgsqll vlllllassp lalgipmysi itpnvlrles eetivleahd aqgdipvtvt
       61 vqdflkrqvl tsektvltga sghlrsvsik ipaskefnsd keghkyvtvv anfgetvvek
      121 avmvsfqsgy lfiqtdktiy tpgstvlyri ftvdnnllpv gktvviliet pdgipvkrdi
      181 lssnnqhgil plswnipelv nmgqwkiraf yehapkqifs aefevkeyvl psfevrvept
      241 etfyyiddpn glevsiiakf lygknvdgta fvifgvqdgd kkislahslt rvviedgvgd
      301 avltrkvlme gvrpsnadal vgkslyvsvt vilhsgsdmv eaersgipiv tspyqihftk
      361 tpkffkpamp fdlmvfvtnp dgspaskvlv vtqgsnakal tqddgvakls intpnsrqpl
      421 titvrtkkdt lpesrqatkt meahpystmh nsnnylhlsv srmelkpgdn lnvnfhlrtd
      481 pgheakiryy tylvmnkgkl lkagrqvrep gqdlvvlslp itpefipsfr lvayytliga
      541 sgqrevvads vwvdvkdsci gtlvvkgdpr dnhlapgqqt tlriegnqga rvglvavdkg
      601 vfvlnkknkl tqskiwdvve kadigctpgs gknyagvfmd aglafktsqg lqteqradle
      661 ctkpaarrrr svqlmerrmd kagqytdkgl rkccedgmrd ipmryscqrr arlitqgenc
      721 ikafidccnh itklreqhrr dhvlglarse leediipeed iisrshfpqs wlwtieelke
      781 pekngistkv mniflkdsit tweilavsls dkkgicvadp yeirvmqdff idlrlpysvv
      841 rneqveirav lfnyreqeel kvrvellhnp afcsmatakn ryfqtikipp kssvavpyvi
      901 vplkigqqev evkaavfnhf isdgvkktlk vvpegmrink tvaihtldpe klgqggvqkv
      961 dvpaadlsdq vpdtdsetri ilqgspvvqm aedavdgerl khlivtpagc geqnmigmtp
     1021 tviavhyldq teqwekfgie krqealelik kgytqqlafk qpssayaafn nrppstwlta
     1081 yvvkvfslaa nliaidshvl cgavkwlile kqkpdgvfqe dgpvihqemi ggfrnakead
     1141 vsltafvlia lqeardiceg qvnslpgsin kageyieasy mnlqrpytva iagyalalmn
     1201 kleepylgkf lntakdrnrw eepdqqlynv eatsyallal lllkdfdsvp pvvrwlneqr
     1261 yygggygstq atfmvfqala qyqtdvpdhk dlnmdvsfhl psrssattfr llwengnllr
     1321 seetkqneaf sltakgkgrg tlsvvavyha klkskvtckk fdlrvsirpa petakkpeea
     1381 kntmfleict kylgdvdatm sildismmtg fapdtkdlel lasgvdryis kyemnkafsn
     1441 kntliiylek ishteedclt fkvhqyfnvg liqpgsvkvy syynleesct rfyhpekddg
     1501 mlsklchsem crcaeencfm qqsqekinln vrldkacepg vdyvyktelt niellddfde
     1561 ytmtiqqvik sgsdevqagq qrkfishikc rnalklqkgk kylmwglssd lwgekpntsy
     1621 iigkdtwveh wpeaeecqdq kyqkqceelg aftesmvvyg cpn
//
LOCUS       NP_001390575             905 aa            linear   ROD 27-AUG-2025
DEFINITION  synphilin-1 isoform 3 [Mus musculus].
ACCESSION   NP_001390575 XP_030106438
VERSION     NP_001390575.1
DBSOURCE    REFSEQ: accession NM_001403646.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 905)
  AUTHORS   Dutta,D., Paidi,R.K., Raha,S., Roy,A., Chandra,S. and Pahan,K.
  TITLE     Treadmill exercise reduces alpha-synuclein spreading via PPARalpha
  JOURNAL   Cell Rep 40 (2), 111058 (2022)
   PUBMED   35830804
  REMARK    GeneRIF: Treadmill exercise reduces alpha-synuclein spreading via
            PPARalpha.
            Erratum:[Cell Rep. 2024 Aug 27;43(8):114546. doi:
            10.1016/j.celrep.2024.114546. PMID: 39024097]
REFERENCE   2  (residues 1 to 905)
  AUTHORS   Won,S.Y., Park,J.J., You,S.T., Hyeun,J.A., Kim,H.K., Jin,B.K.,
            McLean,C., Shin,E.Y. and Kim,E.G.
  TITLE     p21-activated kinase 4 controls the aggregation of alpha-synuclein
            by reducing the monomeric and aggregated forms of alpha-synuclein:
            involvement of the E3 ubiquitin ligase NEDD4-1
  JOURNAL   Cell Death Dis 13 (6), 575 (2022)
   PUBMED   35773260
  REMARK    GeneRIF: p21-activated kinase 4 controls the aggregation of
            alpha-synuclein by reducing the monomeric and aggregated forms of
            alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 905)
  AUTHORS   Chen,D.D., Gao,L.P., Wu,Y.Z., Chen,J., Hu,C., Xiao,K., Chen,C.,
            Shi,Q. and Dong,X.P.
  TITLE     Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells
  JOURNAL   ACS Chem Neurosci 12 (20), 3838-3854 (2021)
   PUBMED   34595918
  REMARK    GeneRIF: Accumulation of Prion and Abnormal Prion Protein Induces
            Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from
            Prion Diseases and in the Cultured Cells.
REFERENCE   4  (residues 1 to 905)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 905)
  AUTHORS   Han,J.Y., Shin,C. and Choi,Y.P.
  TITLE     Preclinical Detection of Alpha-Synuclein Seeding Activity in the
            Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
  JOURNAL   Viruses 13 (5), 759 (2021)
   PUBMED   33926043
  REMARK    GeneRIF: Preclinical Detection of Alpha-Synuclein Seeding Activity
            in the Colon of a Transgenic Mouse Model of Synucleinopathy by
            RT-QuIC.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 905)
  AUTHORS   Soehn,A.S., Franck,T., Biskup,S., Giaime,E., Melle,C., Rott,R.,
            Cebo,D., Kalbacher,H., Ott,E., Pahnke,J., Meitinger,T., Kruger,R.,
            Gasser,T., Berg,D., von Eggeling,F., Engelender,S., da Costa,C.A.
            and Riess,O.
  TITLE     Periphilin is a novel interactor of synphilin-1, a protein
            implicated in Parkinson's disease
  JOURNAL   Neurogenetics 11 (2), 203-215 (2010)
   PUBMED   19730898
REFERENCE   7  (residues 1 to 905)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   8  (residues 1 to 905)
  AUTHORS   Kuhn,K., Zhu,X.R., Lubbert,H. and Stichel,C.C.
  TITLE     Parkin expression in the developing mouse
  JOURNAL   Brain Res Dev Brain Res 149 (2), 131-142 (2004)
   PUBMED   15063093
REFERENCE   9  (residues 1 to 905)
  AUTHORS   Goldberg,M.S., Fleming,S.M., Palacino,J.J., Cepeda,C., Lam,H.A.,
            Bhatnagar,A., Meloni,E.G., Wu,N., Ackerson,L.C., Klapstein,G.J.,
            Gajendiran,M., Roth,B.L., Chesselet,M.F., Maidment,N.T.,
            Levine,M.S. and Shen,J.
  TITLE     Parkin-deficient mice exhibit nigrostriatal deficits but not loss
            of dopaminergic neurons
  JOURNAL   J Biol Chem 278 (44), 43628-43635 (2003)
   PUBMED   12930822
REFERENCE   10 (residues 1 to 905)
  AUTHORS   O'Farrell,C., Pickford,F., Vink,L., McGowan,E. and Cookson,M.R.
  TITLE     Sequence conservation between mouse and human synphilin-1
  JOURNAL   Neurosci Lett 322 (1), 9-12 (2002)
   PUBMED   11958831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121943.3 and AC124178.3.
            
            On Apr 1, 2022 this sequence version replaced XP_030106438.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1657322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.27 cM"
     Protein         1..905
                     /product="synphilin-1 isoform 3"
                     /note="alpha-synuclein-interacting protein; synphilin-1"
                     /calculated_mol_wt=99370
     Region          <306..448
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          361..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(364..365,368..370,372..373,377,384,393,395,397,
                     401..402,405..407,409..410,414,417,426,428,430,434..435,
                     438..440,442..443,447)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          395..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          451..494
                     /region_name="SNCAIP_SNCA_bd"
                     /note="Synphilin-1 alpha-Synuclein-binding domain;
                     pfam16700"
                     /db_xref="CDD:435527"
     CDS             1..905
                     /gene="Sncaip"
                     /gene_synonym="2810407O15Rik; 4933427B05Rik; SYPH1"
                     /coded_by="NM_001403646.1:191..2908"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:67847"
                     /db_xref="MGI:MGI:1915097"
ORIGIN      
        1 meapeyldld eidfsddisy svtslktipa lcrrcdsqne drsvsssgwn cgvstlitnp
       61 qkptgiadvy skfrpvkrvs plkhqpetle nnenedqknn tveyqkgget dqgpqpeels
      121 pedgvgglpg kgsepsqalg elehydldmd eildvpyiks sqqlapltkv tsekrilglc
      181 ttinglsakt cpiastenst pnmtpfcvls pvksphlrka ptalrdqhkl stedsesspa
      241 lgkcgpayes enhskdflnk vfsdphsrki eksgpdcklr sfhlqssaag akteepingm
      301 nwtntqgtee rteylkkvrs ilnivnegqi sllngqlecv rwmvseteai aelscskdfp
      361 slihyagcyg qekillwllq fmqeqgisld evdregnsav hvasqhgylg ciqtlveyga
      421 nvtmqnhage kpsqsaerhg htlcsrylvv vetcmslasq vvkltkqlke qtvervtlqs
      481 qlqqlleaqk segkslpssp sspsspastk sqwkaldtde estgkskvga qegiqvlgsl
      541 svssrartkg kdedsdkilr qllgkeisen vctqeklsle fqdaqassrn skkiplekre
      601 lklarlrqlm qrslsesdtd snnsedpknt pvkradrprp qpivesvenv dsaeslhlmi
      661 kkhslasgrr fpfgmkasks ldghspspts essepdldsh gpglgmtppt qpsteatqss
      721 pdstaaqkva tspksalksp sskrrtsqns klrvtfeepv vqmeqtglel ngekdkdkgr
      781 apqrtsesge qmkrpfgtfr simeslsgnq nnnnnyqpas qlktctlplt slgrktadak
      841 gnpvspaskg knkaamyssc ihlpsnalve ehlrdyarhn dikrnatkty hmkhtaepep
      901 relfl
//
LOCUS       NP_001273056             494 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear factor 1 B-type isoform 4 [Mus musculus].
ACCESSION   NP_001273056
VERSION     NP_001273056.1
DBSOURCE    REFSEQ: accession NM_001286127.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 494)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (residues 1 to 494)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   9  (residues 1 to 494)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   10 (residues 1 to 494)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592283.5, BX324149.4 and AL773518.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023366.1, SRR14777535.1589015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.4 cM"
     Protein         1..494
                     /product="nuclear factor 1 B-type isoform 4"
                     /note="nuclear factor 1 B-type; nuclear factor 1/B;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /calculated_mol_wt=55124
     Region          10..47
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          69..173
                     /region_name="MH1"
                     /note="MH1 domain; pfam03165"
                     /db_xref="CDD:460833"
     Region          209..489
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     CDS             1..494
                     /gene="Nfib"
                     /gene_synonym="6720429L07Rik; CTF; E030026I10Rik; NF-I/B;
                     NF1-B; NFI-B"
                     /coded_by="NM_001286127.2:620..2104"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:18028"
                     /db_xref="MGI:MGI:103188"
ORIGIN      
        1 mmyspicltq defhpfieal lphvraiayt wfnlqarkrk yfkkhekrms kdeeravkde
       61 llsekpeikq kwasrllakl rkdirqeyre dfvltvtgkk hpccvlsnpd qkgkirridc
      121 lrqadkvwrl dlvmvilfkg iplestdger lmksphctnp alcvqphhit vsvkeldlfl
      181 ayyvqeqdsg qsgspshsdp aknppgyled sfvksgvfnv selvrvsrtp itqgtgvnfp
      241 igeipsqpyy hdmnsgvnlq rslssppssk rpktisiden mepsptgdfy pspnspaags
      301 rtwherdqdm sspttmkkpe kplfsstspq dssprlstfp qhhhpgipgv ahsvistrtp
      361 pppsplpfpt qailppapss yfshptiryp phlnpqdtlk nyvpsydpss pqtsqpnssg
      421 qvvgkvpghf tpvlapsphp savrpvtltm tdtkpittst eaytasgtsq anryvglspr
      481 dpsflhqqqs wylg
//
LOCUS       NP_032391                537 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-18 receptor 1 isoform a precursor [Mus musculus].
ACCESSION   NP_032391
VERSION     NP_032391.1
DBSOURCE    REFSEQ: accession NM_008365.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 537)
  AUTHORS   Shen,J., Zhang,Y., Tang,W., Yang,M., Cheng,T., Chen,Y., Yu,S.,
            Guo,Q., Cao,L., Wang,X., Xiao,H., Wang,L., Wang,C., Liu,C.Y. and
            Meng,G.
  TITLE     Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to
            suppress tumor growth
  JOURNAL   Nat Immunol 26 (3), 416-428 (2025)
   PUBMED   39891018
REFERENCE   2  (residues 1 to 537)
  AUTHORS   Zhang,X., Li,S., Lason,W., Greco,M., Klenerman,P. and Hinks,T.S.C.
  TITLE     MAIT cells protect against sterile lung injury
  JOURNAL   Cell Rep 44 (2), 115275 (2025)
   PUBMED   39918959
REFERENCE   3  (residues 1 to 537)
  AUTHORS   McManus,R.M., Komes,M.P., Griep,A., Santarelli,F., Schwartz,S.,
            Ramon Perea,J., Schlachetzki,J.C.M., Bouvier,D.S., Khalil,M.A.,
            Lauterbach,M.A., Heinemann,L., Schluter,T., Pour,M.S., Lovotti,M.,
            Stahl,R., Duthie,F., Rodriguez-Alcazar,J.F., Schmidt,S.V.,
            Spitzer,J., Noori,P., Maillo,A., Boettcher,A., Herron,B.,
            McConville,J., Gomez-Cabrero,D., Tegner,J., Glass,C.K., Hiller,K.,
            Latz,E. and Heneka,M.T.
  TITLE     NLRP3-mediated glutaminolysis controls microglial phagocytosis to
            promote Alzheimer's disease progression
  JOURNAL   Immunity 58 (2), 326-343 (2025)
   PUBMED   39904338
REFERENCE   4  (residues 1 to 537)
  AUTHORS   Slusny,B., Zimmer,V., Nasiri,E., Lutz,V., Huber,M., Buchholz,M.,
            Gress,T.M., Roth,K. and Bauer,C.
  TITLE     Optimized Spheroid Model of Pancreatic Cancer Demonstrates
            Influence of Macrophage-T Cell Interaction for Intratumoral T Cell
            Motility
  JOURNAL   Cancers (Basel) 17 (1), 51 (2024)
   PUBMED   39796680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 537)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   6  (residues 1 to 537)
  AUTHORS   Sergi,B. and Penttila,I.
  TITLE     Interleukin 18 receptor
  JOURNAL   J Biol Regul Homeost Agents 18 (1), 55-61 (2004)
   PUBMED   15323361
  REMARK    GeneRIF: review of structure, function and tissue distribution of
            IL-18R [review]
            Review article
REFERENCE   7  (residues 1 to 537)
  AUTHORS   Seki,E., Tsutsui,H., Tsuji,N.M., Hayashi,N., Adachi,K., Nakano,H.,
            Futatsugi-Yumikura,S., Takeuchi,O., Hoshino,K., Akira,S.,
            Fujimoto,J. and Nakanishi,K.
  TITLE     Critical roles of myeloid differentiation factor 88-dependent
            proinflammatory cytokine release in early phase clearance of
            Listeria monocytogenes in mice
  JOURNAL   J Immunol 169 (7), 3863-3868 (2002)
   PUBMED   12244183
REFERENCE   8  (residues 1 to 537)
  AUTHORS   Okamoto,M., Kato,S., Oizumi,K., Kinoshita,M., Inoue,Y., Hoshino,K.,
            Akira,S., McKenzie,A.N., Young,H.A. and Hoshino,T.
  TITLE     Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung
            injury in mice: a potential role for cytokines, chemokines, and
            natural killer cells in the pathogenesis of interstitial pneumonia
  JOURNAL   Blood 99 (4), 1289-1298 (2002)
   PUBMED   11830478
REFERENCE   9  (residues 1 to 537)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
REFERENCE   10 (residues 1 to 537)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167126.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and are consistent with Northern
            analyses.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.27 cM"
     Protein         1..537
                     /product="interleukin-18 receptor 1 isoform a precursor"
                     /EC_number="3.2.2.6"
                     /note="interleukin 1 receptor related protein; IL-18R1;
                     IL-1Rrp; IL1R-rp; IL-18R-1; IL-18Ralpha; IL1
                     receptor-related protein; CD218 antigen-like family member
                     A; IL-18R-alpha; interleukin-18 receptor alpha"
                     /calculated_mol_wt=59468
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2151
     Region          3..>98
                     /region_name="Ig_6"
                     /note="Immunoglobulin domain; pfam18452"
                     /db_xref="CDD:465773"
     mat_peptide     20..537
                     /product="Interleukin-18 receptor 1. /id=PRO_0000015449"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61098.1)"
                     /calculated_mol_wt=59468
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            71
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            107
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            111
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          131..205
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          137..141
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409415"
     Region          149..156
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409415"
     Region          <157..257
                     /region_name="PHA02785"
                     /note="IL-beta-binding protein; Provisional"
                     /db_xref="CDD:165149"
     Region          179..184
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409415"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409415"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          212..312
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          230..234
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409526"
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          243..246
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409526"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409526"
     Region          293..298
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409526"
     Site            295
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          306..309
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409526"
     Site            327..347
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61098.1)"
     Region          375..516
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..537
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /coded_by="NM_008365.2:381..1994"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS35549.1"
                     /db_xref="GeneID:16182"
                     /db_xref="MGI:MGI:105383"
ORIGIN      
        1 mhheeliltl cilivksask scihrsqihv vegepfylkp cgisapvhrn etatmrwfkg
       61 sasheyreln nrssprvtfh dhtlefwpve medegtyisq vgndrrnwtl nvtkrnkhsc
      121 fsdklvtsrd vevnkslhit cknpnyeeli qdtwlyknck eisktprilk daefgdegyy
      181 scvfsvhhng trynitktvn itviegrskv tpailgpkce kvgvelgkdv elncsaslnk
      241 ddlfywsirk edssdpnvqe drketttwis egklhaskil rfqkitenyl nvlynctvan
      301 eeaidtksfv lvrkeipdip ghvftggvtv lvlasvaavc ivilcviykv dlvlfyrria
      361 erdetltdgk tydafvsylk echpenkeey tfavetlprv lekqfgyklc iferdvvpgg
      421 avveeihsli eksrrliivl sqsyltngar relesglhea lverkikiil ieftpasnit
      481 flppslkllk syrvlkwrad spsmnsrfwk nlvylmpaka vkpwreesea rsvlsap
//
LOCUS       NP_033289                294 aa            linear   ROD 27-AUG-2025
DEFINITION  osteopontin isoform 4 precursor [Mus musculus].
ACCESSION   NP_033289
VERSION     NP_033289.2
DBSOURCE    REFSEQ: accession NM_009263.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 294)
  AUTHORS   Cain,J.W., Erikson,D.W., Seo,H., Ross,A., Burghardt,R.C.,
            Bazer,F.W. and Johnson,G.A.
  TITLE     SPARC expression in the mouse decidua, placenta, and fetus:
            correlations with SPP1 expression
  JOURNAL   Placenta 168, 125-134 (2025)
   PUBMED   40544540
REFERENCE   2  (residues 1 to 294)
  AUTHORS   Moraitis,I., Taelman,J., Arozamena,B., Mularoni,L., Wienskowska,O.,
            Sanjuan Garriga,X., Arregui,L., Stefanovic,M., Modolell Farre,I.,
            Guedea,F., Diaz,M. and Guiu,J.
  TITLE     Mucosal Macrophages Govern Intestinal Regeneration in Response to
            Injury
  JOURNAL   Gastroenterology 169 (1), 119-135 (2025)
   PUBMED   40086603
REFERENCE   3  (residues 1 to 294)
  AUTHORS   Wu,S., Bian,Y., Zhang,C., Liu,K., Sun,F., Chen,E., Zhou,C., Yu,L.,
            Chen,G. and Wu,M.
  TITLE     Merlin controls limb development and thumb formation by regulating
            primary cilium-hedgehog signaling
  JOURNAL   Cell Rep 44 (6), 115849 (2025)
   PUBMED   40503937
REFERENCE   4  (residues 1 to 294)
  AUTHORS   Trehan,R., Huang,P., Zhu,X.B., Wang,X., Soliman,M., Strepay,D.,
            Nur,A., Kedei,N., Arhin,M., Ghabra,S., Rodriguez-Matos,F.,
            Benmebarek,M.R., Ma,C., Korangy,F. and Greten,T.F.
  TITLE     SPP1 + macrophages cause exhaustion of tumor-specific T cells in
            liver metastases
  JOURNAL   Nat Commun 16 (1), 4242 (2025)
   PUBMED   40335453
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 294)
  AUTHORS   Jafree,D.J., Perera,C., Ball,M., Tolomeo,D., Pomeranz,G.,
            Wilson,L., Davis,B., Mason,W.J., Funk,E.M., Kolatsi-Joannou,M.,
            Polschi,R., Malik,S., Stewart,B.J., Price,K.L., Mitchell,H.,
            Motallebzadeh,R., Muto,Y., Lees,R., Needham,S., Moulding,D.,
            Chandler,J.C., Nandanwar,S., Walsh,C.L., Winyard,P.J.D.,
            Scambler,P.J., Hagerling,R., Clatworthy,M.R., Humphreys,B.D.,
            Lythgoe,M.F., Walker-Samuel,S., Woolf,A.S. and Long,D.A.
  TITLE     Microvascular aberrations found in human polycystic kidneys are an
            early feature in a Pkd1 mutant mouse model
  JOURNAL   Dis Model Mech 18 (4) (2025)
   PUBMED   40114603
REFERENCE   6  (residues 1 to 294)
  AUTHORS   Worcester,E.M., Blumenthal,S.S., Beshensky,A.M. and Lewand,D.L.
  TITLE     The calcium oxalate crystal growth inhibitor protein produced by
            mouse kidney cortical cells in culture is osteopontin
  JOURNAL   J Bone Miner Res 7 (9), 1029-1036 (1992)
   PUBMED   1414495
REFERENCE   7  (residues 1 to 294)
  AUTHORS   Waterhouse,P., Parhar,R.S., Guo,X., Lala,P.K. and Denhardt,D.T.
  TITLE     Regulated temporal and spatial expression of the calcium-binding
            proteins calcyclin and OPN (osteopontin) in mouse tissues during
            pregnancy
  JOURNAL   Mol Reprod Dev 32 (4), 315-323 (1992)
   PUBMED   1497879
REFERENCE   8  (residues 1 to 294)
  AUTHORS   Kozak,C.A. and Stephenson,D.A.
  TITLE     Mouse chromosome 5
  JOURNAL   Mamm Genome 3 Spec No, S65-S80 (1992)
   PUBMED   1498444
  REMARK    Review article
REFERENCE   9  (residues 1 to 294)
  AUTHORS   Craig,A.M. and Denhardt,D.T.
  TITLE     The murine gene encoding secreted phosphoprotein 1 (osteopontin):
            promoter structure, activity, and induction in vivo by estrogen and
            progesterone
  JOURNAL   Gene 100, 163-171 (1991)
   PUBMED   2055467
REFERENCE   10 (residues 1 to 294)
  AUTHORS   Groves,M.G. and Osterman,J.V.
  TITLE     Host defenses in experimental scrub typhus: genetics of natural
            resistance to infection
  JOURNAL   Infect Immun 19 (2), 583-588 (1978)
   PUBMED   415980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124106.11, AK160540.1 and AI882055.1.
            
            On Jan 18, 2008 this sequence version replaced NP_033289.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, uses a
            downstream in-frame start codon and lacks an exon in the coding
            region, compared to variant 1. Variants 4 and 5 encode the same
            isoform (4), which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057858.1, AK154908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     Protein         1..294
                     /product="osteopontin isoform 4 precursor"
                     /note="minopontin; early T-lymphocyte activation 1
                     protein; calcium oxalate crystal growth inhibitor protein;
                     bone sialoprotein 1; osteopontin-like protein; 44 kDa bone
                     phosphoprotein"
                     /calculated_mol_wt=30746
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1731
     mat_peptide     17..294
                     /product="Osteopontin. /id=PRO_0000020322"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
                     /calculated_mol_wt=30746
     Region          22..294
                     /region_name="Osteopontin"
                     /note="pfam00865"
                     /db_xref="CDD:459969"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Region          42..274
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            62
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            77
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            80
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            112
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            123
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            132
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            137
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Region          144..146
                     /region_name="Cell attachment site"
                     /note="propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            170
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P31096; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            176
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            219
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            234
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            260
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            271
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            288
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            288
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     Site            290
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P10923.1)"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P10451; propagated from
                     UniProtKB/Swiss-Prot (P10923.1)"
     CDS             1..294
                     /gene="Spp1"
                     /gene_synonym="2AR; Apl-1; BNSP; Bsp; BSPI; Eta; ETA-1;
                     OP; Opn; Opnl; Ric; Spp-1"
                     /coded_by="NM_009263.3:101..985"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS19486.1"
                     /db_xref="GeneID:20750"
                     /db_xref="MGI:MGI:98389"
ORIGIN      
        1 mrlavicfcl fgiasslpvk vtdsgsseek lyslhpdpia twlvpdpsqk qnllapqnav
       61 sseekddfkq etlpsnsnes hdhmdddddd ddddgdhaes edsvdsdesd eshhsdesde
      121 tvtastqadt ftpivptvdv pngrgdslay glrsksrsfq vsdeqypdat dedltshmks
      181 geskesldvi pvaqllsmps dqdnngkgsh essqldepsl ethrlehske sqesadqsdv
      241 idsqasskas lehqshkfhs hkdklvldpk skeddrylkf rishelesss sevn
//
LOCUS       NP_444400               1140 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRIM33 isoform 1 [Mus musculus].
ACCESSION   NP_444400 XP_131075
VERSION     NP_444400.2
DBSOURCE    REFSEQ: accession NM_053170.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1140)
  AUTHORS   Shen,X., Li,X., Wu,T., Guo,T., Lv,J., He,Z., Luo,M., Zhu,X.,
            Tian,Y., Lai,W., Dong,C., Hu,X. and Wu,L.
  TITLE     TRIM33 plays a critical role in regulating dendritic cell
            differentiation and homeostasis by modulating Irf8 and Bcl2l11
            transcription
  JOURNAL   Cell Mol Immunol 21 (7), 752-769 (2024)
   PUBMED   38822080
REFERENCE   2  (residues 1 to 1140)
  AUTHORS   Tiniakou,I., Hsu,P.F., Lopez-Zepeda,L.S., Garipler,G., Esteva,E.,
            Adams,N.M., Jang,G., Soni,C., Lau,C.M., Liu,F.,
            Khodadadi-Jamayran,A., Rodrick,T.C., Jones,D., Tsirigos,A.,
            Ohler,U., Bedford,M.T., Nimer,S.D., Kaartinen,V., Mazzoni,E.O. and
            Reizis,B.
  TITLE     Genome-wide screening identifies Trim33 as an essential regulator
            of dendritic cell differentiation
  JOURNAL   Sci Immunol 9 (94), eadi1023 (2024)
   PUBMED   38608038
  REMARK    GeneRIF: Genome-wide screening identifies Trim33 as an essential
            regulator of dendritic cell differentiation.
REFERENCE   3  (residues 1 to 1140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1140)
  AUTHORS   Yuan,C., Jin,G., Li,P., Wang,W., Ge,C., Pan,Y., Zhang,Q., Mo,J.,
            Kuang,D., Liu,L., Zhang,X., Liang,H., Zhang,W., Tang,X., Li,Z.,
            Liu,J., Xu,G., Chen,X., Ding,Z.Y. and Zhang,B.
  TITLE     Tubular cell transcriptional intermediary factor 1gamma deficiency
            exacerbates kidney injury-induced tubular cell polyploidy and
            fibrosis
  JOURNAL   Kidney Int 104 (4), 769-786 (2023)
   PUBMED   37482091
  REMARK    GeneRIF: Tubular cell transcriptional intermediary factor 1gamma
            deficiency exacerbates kidney injury-induced tubular cell
            polyploidy and fibrosis.
REFERENCE   5  (residues 1 to 1140)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1140)
  AUTHORS   Yan,K.P., Dolle,P., Mark,M., Lerouge,T., Wendling,O., Chambon,P.
            and Losson,R.
  TITLE     Molecular cloning, genomic structure, and expression analysis of
            the mouse transcriptional intermediary factor 1 gamma gene
  JOURNAL   Gene 334, 3-13 (2004)
   PUBMED   15256250
REFERENCE   7  (residues 1 to 1140)
  AUTHORS   Okubo,T. and Hogan,B.L.
  TITLE     Hyperactive Wnt signaling changes the developmental potential of
            embryonic lung endoderm
  JOURNAL   J Biol 3 (3), 11 (2004)
   PUBMED   15186480
REFERENCE   8  (residues 1 to 1140)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (residues 1 to 1140)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 1140)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164089.4 and AY458590.1.
            
            On Dec 19, 2006 this sequence version replaced NP_444400.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY458590.1, SRR14777534.589626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     Protein         1..1140
                     /product="E3 ubiquitin-protein ligase TRIM33 isoform 1"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase TRIM33; TIF1-gamma;
                     ectodermin homolog; tripartite motif-containing protein
                     33; transcription intermediary factor 1-gamma; RING-type
                     E3 ubiquitin transferase TRIM33"
                     /calculated_mol_wt=123544
     Region          135..202
                     /region_name="RING-HC_TIF1gamma"
                     /note="RING finger, HC subclass, found in transcriptional
                     inknown asiary factor 1 gamma (TIF1gamma); cd16766"
                     /db_xref="CDD:438422"
     Region          224..277
                     /region_name="Bbox1_TIF1g_C-VI"
                     /note="B-box-type 1 zinc finger found in transcriptional
                     intermediary factor 1 gamma (TIF1-gamma); cd19847"
                     /db_xref="CDD:380905"
     Region          282..334
                     /region_name="Bbox2_TIF1g_C-VI"
                     /note="B-box-type 2 zinc finger found in transcription
                     intermediary factor 1 gamma (TIF1-gamma); cd19830"
                     /db_xref="CDD:380888"
     Region          313..415
                     /region_name="Necessary for oligomerization.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          333..459
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Site            order(337,340..341,343..345,348,351,365..366,369,372..373,
                     376..377,380,387..388,391,394..395,398..399,402,411..412,
                     415,419,423..424,427..428,430..431,439,442..443,446,
                     449..450)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467844"
     Site            529
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            549
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            591
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          <600..>753
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Site            605
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            612
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            618
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          655..674
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          686..705
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          716..832
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            776
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            782
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            806
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            816
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            828
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            875
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          902..947
                     /region_name="PHD_TIF1gamma"
                     /note="PHD finger found in transcriptional intermediary
                     factor 1 gamma (TIF1gamma); cd15624"
                     /db_xref="CDD:277094"
     Site            order(902,907..908,911..916,923,936..937)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277094"
     Site            964
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            966
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          971..1096
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(999,1003,1006,1048,1052,1075)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     Site            1064
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Region          1101..1140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            1115
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            1118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     Site            1132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UPN9; propagated from
                     UniProtKB/Swiss-Prot (Q99PP7.2)"
     CDS             1..1140
                     /gene="Trim33"
                     /gene_synonym="8030451N04Rik; Ecto; Tif1g"
                     /coded_by="NM_053170.3:587..4009"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38573.1"
                     /db_xref="GeneID:94093"
                     /db_xref="MGI:MGI:2137357"
ORIGIN      
        1 maenkgggea esggggsgsa pvtagaagpt aqeaepplaa vlveeeeeeg gragaeggaa
       61 gpddggvaaa ssssapaasv paasvgsavp ggaastpapa aapapapapa papapapapa
      121 pgsssgpplg ppaslldtca vcqqslqsrr eaepkllpcl hsfclrclpe perqlsvpip
      181 ggsngdvqqv gvircpvcrq ecrqidlvdn yfvkdtseap sssdekseqv ctscednasa
      241 vgfcvecgew lcktcieahq rvkftkdhli rkkedvsesv gtsgqrpvfc pvhkqeqlkl
      301 fcetcdrltc rdcqllehke hryqfleeaf qnqkgaienl lakllekkny vhfaatqvqn
      361 rikevnetnk rveqeikvai ftlineinkk gksllqqlen vtkerqmkll qqqnditgls
      421 rqvkhvmnft nwaiasgsst allyskrlit fqlrhilkar cdpvpaanga irfhcdptfw
      481 aknvvnlgnl vieskpapgy tpnvvvgqvp pgtnhisktp gqinlaqlrl qhmqqqvyaq
      541 khqqlqqmrl qqppapiptt tattqqhprq aapqmlqqqp prlisvqtmq rgnmncgafq
      601 ahqmrlaqna aripgiprhs apqysmmqph lqrqhsnpgh agpfpvvsah npinptsptt
      661 atmananrgp tspsvtaiel ipsvtnpenl pslpdippiq ledagsssld nllsryisgs
      721 hlppqptstm npspgpsals pgssglsnsh tpvrppstss tgsrgscgss grtaeksahs
      781 fksdqvkvkq epgteeeics fsgavkqekt edgrrsacml sspessltpp lstnlhlese
      841 ldtltglenh vkteptdise sckqsglsnl vngkspirnl mhrsariggd gnskdddpne
      901 dwcavcqngg dllccekcpk vfhltchvpt llsfpsgdwi ctfcrdigkp eveydcdnmq
      961 hskkgktaqg lspvdqrkce rlllylyche lsiefqepvp vsipnyykii kkpmdlstvk
     1021 kklqkkhsqh yqipddfvad vrlifkncer fnemmkvvqv yadtqeinlk gdsevakagk
     1081 avalyfedkl seiysdrtft plpefeqded dgevtedsde dfiqprrkrl ksderpvhik
//
LOCUS       NP_001390172             189 aa            linear   ROD 27-AUG-2025
DEFINITION  GTPase KRas isoform 2 [Mus musculus].
ACCESSION   NP_001390172 XP_006506981
VERSION     NP_001390172.1
DBSOURCE    REFSEQ: accession NM_001403243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 189)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 189)
  AUTHORS   Quijano,E., Martinez-Saucedo,D., Ianniello,Z., Pinto-Medici,N.,
            Rackear,M., Chen,H., Lola-Pereira,L., Liu,Y., Hegan,D., Shan,X.,
            Tseng,R., Yugawa,D., Chowdhury,S., Khang,M., Singh,J.P.,
            Abdullah,R., Azhir,P., Kashima,S., Woods,W.S., Gosstola,N.,
            Turner,B.C., Squinto,S., Ludwig,D.L., Bindra,R.S., Robert,M.E.,
            Braun,D.A., Perez Pinera,P., Saltzman,W.M., Escobar-Hoyos,L.F. and
            Glazer,P.M.
  TITLE     Systemic administration of an RNA binding and cell-penetrating
            antibody targets therapeutic RNA to multiple mouse models of cancer
  JOURNAL   Sci Transl Med 17 (807), eadk1868 (2025)
   PUBMED   40668891
REFERENCE   3  (residues 1 to 189)
  AUTHORS   Suzuki,Y., Sugimori,M., Kanemaru,Y., Onodera,S., Tsuchiya,H.,
            Ikeda,A., Ikeda,R., Goda,Y., Kaneko,H., Irie,K., Sue,S., Ijichi,H.
            and Maeda,S.
  TITLE     Development of a novel PIK3CA-mutated pancreatic tumor mouse model
            and evaluation of the therapeutic effects of a PI3K inhibitor
  JOURNAL   PLoS One 20 (7), e0326491 (2025)
   PUBMED   40638603
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 189)
  AUTHORS   Poirier,A., Tribouillard,L., Kordahi,M., Gelinas,Y., Roy,J.,
            Beaulieu,M.J., Orain,M., Blanchet,M.R., Joubert,P. and Laplante,M.
  TITLE     Generation and characterization of a Cre-inducible ZNF768
            overexpression mouse model
  JOURNAL   Sci Rep 15 (1), 19792 (2025)
   PUBMED   40473701
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 189)
  AUTHORS   Woo,S.M., Lee,H., Kang,J.H., Kang,M., Choi,W., Sim,S.H., Chun,J.W.,
            Han,N., Kim,K.H., Ham,W., Hong,W., Kim,C., Park,J.H., Han,D.,
            Yook,J.I., Lee,W.J. and Kim,S.Y.
  TITLE     Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the
            Tumor-Promoting Effects of a High-Fat Diet
  JOURNAL   Theranostics 15 (13), 6516-6533 (2025)
   PUBMED   40521210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 189)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (residues 1 to 189)
  AUTHORS   Lord,P.G., Hardaker,K.J., Loughlin,J.M., Marsden,A.M. and
            Orton,T.C.
  TITLE     Point mutation analysis of ras genes in spontaneous and chemically
            induced C57Bl/10J mouse liver tumours
  JOURNAL   Carcinogenesis 13 (8), 1383-1387 (1992)
   PUBMED   1499088
REFERENCE   8  (residues 1 to 189)
  AUTHORS   You,M., Wang,Y., Stoner,G., You,L., Maronpot,R., Reynolds,S.H. and
            Anderson,M.
  TITLE     Parental bias of Ki-ras oncogenes detected in lung tumors from
            mouse hybrids
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5804-5808 (1992)
   PUBMED   1352876
REFERENCE   9  (residues 1 to 189)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (residues 1 to 189)
  AUTHORS   Scolnick,E.M., Papageorge,A.G. and Shih,T.Y.
  TITLE     Guanine nucleotide-binding activity as an assay for src protein of
            rat-derived murine sarcoma viruses
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5355-5359 (1979)
   PUBMED   228288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157091.6.
            
            On Mar 29, 2022 this sequence version replaced XP_006506981.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.2316306.1,
                                           SRR10662774.90841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     Protein         1..189
                     /product="GTPase KRas isoform 2"
                     /EC_number="3.6.5.2"
                     /note="Kirsten rat sarcoma oncogene 2, expressed; p21
                     protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene
                     homolog; GTPase KRas"
                     /calculated_mol_wt=21525
     mat_peptide     1..186
                     /product="GTPase KRas. /id=PRO_0000326482"
                     /note="propagated from UniProtKB/Swiss-Prot (P32883.1)"
                     /calculated_mol_wt=21312
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P01116; propagated from
                     UniProtKB/Swiss-Prot (P32883.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine, in GTPase KRas, N-terminally
                     processed. /evidence=ECO:0000250|UniProtKB:P01116;
                     propagated from UniProtKB/Swiss-Prot (P32883.1)"
     Region          3..164
                     /region_name="H_N_K_Ras_like"
                     /note="Ras GTPase family containing H-Ras,N-Ras and
                     K-Ras4A/4B; cd04138"
                     /db_xref="CDD:133338"
     Site            10..17
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133338"
     Site            order(11..12,59..60)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133338"
     Site            order(12..18,28..30,32,35,60,116..117,119..120,145..146)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:133338"
     Site            order(17..18,30..32,34,37,40..41,54..55,57,59..61,63..65,
                     67,69..71,73,102..103,147)
                     /site_type="other"
                     /note="GEF interaction site [polypeptide binding]"
                     /db_xref="CDD:133338"
     Site            order(25,37..41)
                     /site_type="active"
                     /note="effector interaction site [active]"
                     /db_xref="CDD:133338"
     Region          32..40
                     /region_name="Effector region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32883.1)"
     Site            33..40
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:133338"
     Site            35
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133338"
     Site            57..60
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:133338"
     Site            59..77
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:133338"
     Site            104
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P01116; propagated from
                     UniProtKB/Swiss-Prot (P32883.1)"
     Site            116..119
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133338"
     Site            145..147
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133338"
     Region          166..185
                     /region_name="Hypervariable region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32883.1)"
     Site            186
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P01116; propagated from
                     UniProtKB/Swiss-Prot (P32883.1)"
     CDS             1..189
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /coded_by="NM_001403243.1:203..772"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
ORIGIN      
        1 mteyklvvvg aggvgksalt iqliqnhfvd eydptiedsy rkqvvidget clldildtag
       61 qeeysamrdq ymrtgegflc vfainntksf edihhyreqi krvkdsedvp mvlvgnkcdl
      121 psrtvdtkqa qelarsygip fietsaktrq rvedafytlv reirqyrlkk iskeektpgc
      181 vkikkcvim
//
LOCUS       NP_001407288             225 aa            linear   ROD 27-AUG-2025
DEFINITION  LIM/homeobox protein Lhx2 isoform e [Mus musculus].
ACCESSION   NP_001407288
VERSION     NP_001407288.1
DBSOURCE    REFSEQ: accession NM_001420359.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 225)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 225)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 225)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 225)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 225)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (residues 1 to 225)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 225)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 225)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 225)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 225)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.3381834.1,
                                           SRR10662772.369665.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849386 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..225
                     /product="LIM/homeobox protein Lhx2 isoform e"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=25163
     Region          86..142
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..225
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001420359.1:964..1641"
                     /note="isoform e is encoded by transcript variant 7"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mptwqrrqpq pqqlrvqdwa qpglirwvfp tttawalckr ggresarvqd pgqiwqlttp
       61 vtlscnenda ehldrdqpyp ssqktkrmrt sfkhhqlrtm ksyfainhnp dakdlkqlaq
      121 ktgltkrvlq vwfqnarakf rrnllrqent gvdktsdatl qtgtpsgpas elsnaslsps
      181 stpttltdlt sptlptvtsv ltsvpgnleg hephspsqtt ltnlf
//
LOCUS       NP_001396750             737 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 4 [Mus musculus].
ACCESSION   NP_001396750
VERSION     NP_001396750.1
DBSOURCE    REFSEQ: accession NM_001409821.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 737)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 737)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 737)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 737)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 737)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 737)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 737)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 737)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 737)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 737)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.294620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..737
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     4"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=84175
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          149..240
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          171..208
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          320..513
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            330
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          331..417
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          550..581
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          600..719
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(604,606..609,611,615,618,620,670..671,674,694,710)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(612..615,632,639,642..643,646,650,653..659,676..680,
                     688,715,717..718)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(614..615,648..649,652,654,656,669,676..680,717)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(614..615,648..649,652,654,656,669,676..679)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(632,639,642..643,646,650,655,657..659,688,715,
                     717..719)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..737
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409821.1:96..2309"
                     /note="isoform 4 is encoded by transcript variant 14"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtscsvtsdl dfpaqviplk tlnavasvpi myswsplqqn fmvedetvlh
      121 nipymgdevl dqdgtfieel iknydgkvhg drecgfinde ifvelvnalg qynddddddd
      181 gddpdereek qkdlednrdd ketcpprkfp adkifeaiss mfpdkgtaee lkekykelte
      241 qqlpgalppe ctpnidgpna ksvqreqslh sfhtlfcrrc fkydcflhpf hatpntykrk
      301 ntetaldnkp cgpqcyqhle gakefaaalt aeriktppkr pggrrrgrlp nnssrpstpt
      361 isvleskdtd sdreagtetg genndkeeee kkdetsssse ansrcqtpik mkpnieppen
      421 vewsgaeasm frvligtyyd nfcaiarlig tktcrqvyef rvkessiiap vptedvdtpp
      481 rkkkrkhrlw aahcrkiqlk kdgssnhvyn yqpcdhprqp cdsscpcvia qnfcekfcqc
      541 ssecqnrfpg crckaqcntk qcpcylavre cdpdlcltcg aadhwdsknv sckncsiqrg
      601 skkhlllaps dvagwgifik dpvqknefis eycgeiisqd eadrrgkvyd kymcsflfnl
      661 nndfvvdatr kgnkirfanh svnpncyakv mmvngdhrig ifakraiqtg eelffdyrys
      721 qadalkyvgi eremeip
//
LOCUS       NP_082537                378 aa            linear   ROD 27-AUG-2025
DEFINITION  stimulator of interferon genes protein isoform 1 [Mus musculus].
ACCESSION   NP_082537 XP_128954 XP_897592 XP_905219 XP_915440 XP_926696
            XP_926699 XP_991329 XP_994801
VERSION     NP_082537.1
DBSOURCE    REFSEQ: accession NM_028261.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 378)
  AUTHORS   Yang,K., Torres-Ramirez,G., Dobbs,N., Han,J., Asahina,M.,
            Fujinawa,R., Song,K., Liu,Y., Lin,W., Oviedo,A., Chen,C., Zhu,L.,
            Mueller,W.F., Lee,K., Suzuki,T. and Yan,N.
  TITLE     The STING pathway drives noninflammatory neurodegeneration in NGLY1
            deficiency
  JOURNAL   J Exp Med 222 (10) (2025)
   PUBMED   40644312
REFERENCE   2  (residues 1 to 378)
  AUTHORS   Zhou,W., Zhou,J.Z., Ahmed,A., Kim,M.J., Guo,C.J. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     ILC3s sense gut microbiota through STING to initiate immune
            tolerance
  JOURNAL   Immunity 58 (7), 1762-1777 (2025)
   PUBMED   40527323
REFERENCE   3  (residues 1 to 378)
  AUTHORS   Yin,X., Ding,Z., Yu,L., Zhang,X., Gao,Y., Li,Y., Liu,Z. and Fu,Y.X.
  TITLE     Orchestrating intratumoral DC-T cell immunity for enhanced tumor
            control via radiotherapy-activated TLR7/8 prodrugs in mice
  JOURNAL   Nat Commun 16 (1), 6020 (2025)
   PUBMED   40592817
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 378)
  AUTHORS   He,K.Y., Zhao,A., Guo,J.R., Wu,D.H., Liu,H., Gao,F., Liu,M.J.,
            Yang,J.Y., Lei,X.Y., Li,J.Q., Zhang,L., Yan,Z.H., Ding,Q.,
            Huang,Y.W., Cui,R., Jian,Y.P. and Xu,Z.X.
  TITLE     High mobility group A1 (HMGA1) promotes esophageal squamous cell
            carcinoma progression by inhibiting STING-mediated anti-tumor
            immunity
  JOURNAL   Nat Commun 16 (1), 5098 (2025)
   PUBMED   40456764
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 378)
  AUTHORS   Chenuet,P., Mellier,M., Messaoud-Nacer,Y., Culerier,E.,
            Marquant,Q., Fauconnier,L., Rouxel,N., Ledru,A., Rose,S.,
            Ryffel,B., Apetoh,L., Quesniaux,V.F.J. and Togbe,D.
  TITLE     Birch pollen allergen-induced dsDNA release activates cGAS-STING
            signaling and type 2 immune response in mice
  JOURNAL   iScience 28 (5), 112324 (2025)
   PUBMED   40276777
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 378)
  AUTHORS   Ishikawa,H., Ma,Z. and Barber,G.N.
  TITLE     STING regulates intracellular DNA-mediated, type I
            interferon-dependent innate immunity
  JOURNAL   Nature 461 (7265), 788-792 (2009)
   PUBMED   19776740
  REMARK    GeneRIF: STING is essential for host defence against DNA pathogens
            such as HSV-1 and facilitates the adjuvant activity of DNA-based
            vaccines
REFERENCE   7  (residues 1 to 378)
  AUTHORS   Sun,W., Li,Y., Chen,L., Chen,H., You,F., Zhou,X., Zhou,Y., Zhai,Z.,
            Chen,D. and Jiang,Z.
  TITLE     ERIS, an endoplasmic reticulum IFN stimulator, activates innate
            immune signaling through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8653-8658 (2009)
   PUBMED   19433799
REFERENCE   8  (residues 1 to 378)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
REFERENCE   9  (residues 1 to 378)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    GeneRIF: identification, following expression cloning, of a
            molecule (STING; stimulator of interferon genes) that appears
            essential for effective innate immune signalling processes
            GeneRIF: STING (TMEM173) is an endoplasmic reticulum adaptor
            protein that facilitates innate immune signaling
            Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   10 (residues 1 to 378)
  AUTHORS   Jin,L., Waterman,P.M., Jonscher,K.R., Short,C.M., Reisdorph,N.A.
            and Cambier,J.C.
  TITLE     MPYS, a novel membrane tetraspanner, is associated with major
            histocompatibility complex class II and mediates transduction of
            apoptotic signals
  JOURNAL   Mol Cell Biol 28 (16), 5014-5026 (2008)
   PUBMED   18559423
  REMARK    GeneRIF: A novel plasma membrane tetraspanner (MPYS) that is
            associated with type II major histocompatibility complex and
            mediates its transduction of death signals, is described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872463.1, AK089405.1, AK077788.1, AK158458.1 and AC132837.11.
            
            On or before Jul 26, 2009 this sequence version replaced
            XP_926699.1, XP_915440.1, XP_926696.1, XP_991329.1, XP_128954.2,
            XP_897592.1, XP_905219.1, XP_994801.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170724.1, AK089405.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18818105
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.23 cM"
     Protein         1..378
                     /product="stimulator of interferon genes protein isoform
                     1"
                     /note="mitochondrial mediator of IRF3 activation;
                     stimulator of interferon genes protein; endoplasmic
                     reticulum interferon stimulator; stimulator of interferon
                     protein; transmembrane protein 173"
                     /calculated_mol_wt=42699
     Region          1..189
                     /region_name="Mediates interaction with ZDHHC1 and
                     ZDHHC11. /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            18..34
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          44..336
                     /region_name="TMEM173"
                     /note="Transmembrane protein 173; pfam15009"
                     /db_xref="CDD:464441"
     Site            45..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            92..106
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            116..133
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          152..339
                     /region_name="Cyclic dinucleotide-binding domain (CBD).
                     /evidence=ECO:0000269|PubMed:23519410"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q86WV6; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          339..378
                     /region_name="C-terminal tail (CTT).
                     /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:37832545; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000305|PubMed:25636800; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Region          362..365
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q86WV6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TBT3.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000269|PubMed:25636800,
                     ECO:0000269|PubMed:27637147; propagated from
                     UniProtKB/Swiss-Prot (Q3TBT3.2)"
     CDS             1..378
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /coded_by="NM_028261.1:339..1475"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50253.1"
                     /db_xref="GeneID:72512"
                     /db_xref="MGI:MGI:1919762"
ORIGIN      
        1 mpysnlhpai prprghrsky valiflvasl milwvakdpp nhtlkylalh lashelglll
       61 knlcclaeel chvqsryqgs ywkavraclg cpihcmamil lssyfyflqn tadiylswmf
      121 gllvlyksls mllglqsltp aevsavceek klnvahglaw syyigylrli lpglqarirm
      181 fnqlhnnmls gagsrrlyil fpldcgvpdn lsvvdpnirf rdmlpqqnid ragiknrvys
      241 nsvyeileng qpagvciley atplqtlfam sqdakagfsr edrleqaklf crtleeiled
      301 vpesrnncrl ivyqeptdgn sfslsqevlr hirqeekeev tmnapmtsva pppsvlsqep
      361 rllisgmdqp lplrtdli
//
LOCUS       NP_001348140             792 aa            linear   ROD 27-AUG-2025
DEFINITION  glucocorticoid receptor [Mus musculus].
ACCESSION   NP_001348140 XP_006525729
VERSION     NP_001348140.1
DBSOURCE    REFSEQ: accession NM_001361211.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 792)
  AUTHORS   Zhu,W., Vanderhaeghen,T., Timmermans,S., Vandewalle,J.,
            Eggermont,M., Verhoog,N.J.D. and Libert,C.
  TITLE     Modulation of glucocorticoid receptor function under iron overload
  JOURNAL   Front Immunol 16, 1605420 (2025)
   PUBMED   40607412
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 792)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   3  (residues 1 to 792)
  AUTHORS   Short,K.L., Lao,J., Lam,R., Moreau,J.L.M., Ng,J., Piran,M.,
            Combes,A.N., Cottle,D.L. and Cole,T.J.
  TITLE     Disrupted glucocorticoid receptor cell signalling causes a
            ciliogenesis defect in the fetal mouse renal tubule
  JOURNAL   EMBO Rep 26 (11), 2883-2909 (2025)
   PUBMED   40247090
REFERENCE   4  (residues 1 to 792)
  AUTHORS   Cavalcanti de Albuquerque,J.P., Hunter,J., Domingues,R.G.,
            Harno,E., Worth,A.A., Liguori,F.M., D'Alessio,A., Aviello,G.,
            Bechtold,D., White,A., Luckman,S.M., Hepworth,M.R. and
            D'Agostino,G.
  TITLE     Brain sensing of metabolic state regulates circulating monocytes
  JOURNAL   Sci Immunol 10 (106), eadr3226 (2025)
   PUBMED   40184437
REFERENCE   5  (residues 1 to 792)
  AUTHORS   Diba,F., Watson,C.S. and Gametchu,B.
  TITLE     5'UTR sequences of the glucocorticoid receptor 1A transcript encode
            a peptide associated with translational regulation of the
            glucocorticoid receptor
  JOURNAL   J Cell Biochem 81 (1), 149-161 (2001)
   PUBMED   11180405
REFERENCE   6  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Association of the glucocorticoid receptor alternatively-spliced
            transcript 1A with the presence of the high molecular weight
            membrane glucocorticoid receptor in mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 430-446 (1999)
   PUBMED   10412044
REFERENCE   7  (residues 1 to 792)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Multiple glucocorticoid receptor transcripts in membrane
            glucocorticoid receptor-enriched S-49 mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 418-429 (1999)
   PUBMED   10412043
REFERENCE   8  (residues 1 to 792)
  AUTHORS   Strahle,U., Schmidt,A., Kelsey,G., Stewart,A.F., Cole,T.J.,
            Schmid,W. and Schutz,G.
  TITLE     At least three promoters direct expression of the mouse
            glucocorticoid receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6731-6735 (1992)
   PUBMED   1495961
REFERENCE   9  (residues 1 to 792)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   10 (residues 1 to 792)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124417.5 and AC007995.23.
            
            On Apr 27, 2018 this sequence version replaced XP_006525729.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.154344.1,
                                           SRR1660825.50160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 21.09 cM"
     Protein         1..792
                     /product="glucocorticoid receptor"
                     /note="glucocorticoid receptor 1; glucocorticoid receptor
                     subtype P"
                     /calculated_mol_wt=87033
     Region          1..436
                     /region_name="Modulating"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            24
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          27..418
                     /region_name="GCR"
                     /note="Glucocorticoid receptor; pfam02155"
                     /db_xref="CDD:426625"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          67..98
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          148..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            168
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            229
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            243
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585,
                     ECO:0000269|PubMed:21994940; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            324
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:2019585; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            421
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          433..510
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(437,440,454,457,473,479,489,492)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(447..449,455..456,458..459,462..463,471,486..487,
                     493)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(472..474,476,479..480,484..485,488)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Site            496
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          501..792
                     /region_name="Interaction with CLOCK.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Region          503..538
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            508
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            510
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Site            511
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P04150; propagated from
                     UniProtKB/Swiss-Prot (P06537.2)"
     Region          546..792
                     /region_name="NR_LBD_GR"
                     /note="Ligand binding domain of the glucocorticoid
                     receptor, a member of the nuclear receptor superfamily;
                     cd07076"
                     /db_xref="CDD:132761"
     Region          547..712
                     /region_name="Interaction with CRY1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P06537.2)"
     Site            order(560,562..566,629..630,640..641,643,645)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132761"
     Site            order(575,578..579,582,585..586,615..616,619..620,623,626,
                     638,657,661,747,750,752)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132761"
     Site            order(590,594,600,604..605,607..608,611..612,767,770..771,
                     773..774,778)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132761"
     CDS             1..792
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /coded_by="NM_001361211.1:314..2692"
                     /db_xref="CCDS:CCDS37791.1"
                     /db_xref="GeneID:14815"
                     /db_xref="MGI:MGI:95824"
ORIGIN      
        1 mdskeslapp grdevpssll grgrgsvmdl yktlrggatv kvsasspsva aasqadskqq
       61 rilldfskgs asnaqqqqqq qqqqqqqqqq qpqpdlskav slsmglymge tetkvmgndl
      121 gypqqgqlgl ssgetdfrll eesianlnrs tsrpenpkss tpaagcatpt ekefpqthsd
      181 psseqqnrks qpgtnggsvk lyttdqstfd ilqdlefsag spgketnesp wrsdlliden
      241 llsplagedd pfllegdvne dckplilpdt kpkiqdtgdt ilsspssval pqvktekddf
      301 ielctpgvik qeklgpvycq asfsgtniig nkmsaisvhg vstsggqmyh ydmntaslsq
      361 qqdqkpvfnv ippipvgsen wnrcqgsged nltslgamnf agrsvfsngy sspgmrpdvs
      421 sppsssstat gpppklclvc sdeasgchyg vltcgsckvf fkravegqhn ylcagrndci
      481 idkirrkncp acryrkclqa gmnlearktk kkikgiqqat agvsqdtsen anktivpaal
      541 pqltptlvsl leviepevly agydssvpds awrimttlnm lggrqviaav kwakaipgfr
      601 nlhlddqmtl lqyswmflma falgwrsyrq asgnllcfap dliineqrmt lpcmydqckh
      661 mlfistelqr lqvsyeeylc mktllllssv pkeglksqel fdeirmtyik elgkaivkre
      721 gnssqnwqrf yqltklldsm hdvvenllsy cfqtfldksm siefpemlae iitnqipkys
      781 ngnikkllfh qk
//
LOCUS       NP_001415447            1406 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 2 isoform 3 [Mus musculus].
ACCESSION   NP_001415447 XP_036020668
VERSION     NP_001415447.1
DBSOURCE    REFSEQ: accession NM_001428518.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1406)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 1406)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1406)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1406)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1406)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1406)
  AUTHORS   Iulianella,A., Vanden Heuvel,G. and Trainor,P.
  TITLE     Dynamic expression of murine Cux2 in craniofacial, limb, urogenital
            and neuronal primordia
  JOURNAL   Gene Expr Patterns 3 (5), 571-577 (2003)
   PUBMED   12971989
REFERENCE   7  (residues 1 to 1406)
  AUTHORS   Vanden Heuvel,G.B., Quaggin,S.E. and Igarashi,P.
  TITLE     A unique variant of a homeobox gene related to Drosophila cut is
            expressed in mouse testis
  JOURNAL   Biol Reprod 55 (4), 731-739 (1996)
   PUBMED   8879483
REFERENCE   8  (residues 1 to 1406)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1406)
  AUTHORS   Vanden Heuvel,G.B., Bodmer,R., McConnell,K.R., Nagami,G.T. and
            Igarashi,P.
  TITLE     Expression of a cut-related homeobox gene in developing and
            polycystic mouse kidney
  JOURNAL   Kidney Int 50 (2), 453-461 (1996)
   PUBMED   8840273
REFERENCE   10 (residues 1 to 1406)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124189.3 and AC113302.13.
            
            On Mar 14, 2024 this sequence version replaced XP_036020668.1.
            
            Summary: This gene is a member of the Cut family of transcription
            factors that have multiple DNA binding domains and regulate cell
            proliferation and differentiation. This gene is primarily expressed
            in nervous tissues where it controls the proliferation of neuronal
            precursors, and may play a role in organogenesis earlier during
            embryonic development. Mice lacking the encoded protein exhibit
            smaller spinal cords with deficits in neural progenitor development
            as well as in neuroblast and interneuron differentiation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.31488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.02 cM"
     Protein         1..1406
                     /product="homeobox protein cut-like 2 isoform 3"
                     /note="homeobox protein cut-like 2; homeobox protein
                     Cux-2"
                     /calculated_mol_wt=152336
     Region          77..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14529; propagated from
                     UniProtKB/Swiss-Prot (P70298.2)"
     Region          <116..>316
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          331..399
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          440..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          467..543
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          579..608
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          633..656
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          723..749
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          813..886
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          884..957
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          968..1044
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1094..1150
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1157..1372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     CDS             1..1406
                     /gene="Cux2"
                     /gene_synonym="1700051K22Rik; Cutl2; Cux-2"
                     /coded_by="NM_001428518.1:256..4476"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /db_xref="GeneID:13048"
                     /db_xref="MGI:MGI:107321"
ORIGIN      
        1 mvapvlksfq aevvalskrs reaeaaflsv ykqlieapdp vpsfevartl ddrlqrpsfd
       61 psgqrlqdvh iawkrcpepp sareqnegtc ptghtpangn hlpgpedtlv tdtllqknea
      121 erqkglqevh itlaarlgea eekikvlhsa lkatqtelle lrrkydeeaa skadevglim
      181 tnlekanqra eaaqrevesl reqlasvnss irlaccspqg psgekvsfal csgprleaal
      241 askdreilrl lkdaqqlrhs lqeleevsan qiadlerqla akseaieklq ekleaqadye
      301 eiktelsilr amklasstcs lpqkfllekp allaspeedp seddsikgsl gteppyppql
      361 ppppgpedpl spspaqpllg pslgpdgprt fslspfpsla pgerlagdsl lskhmmgpaa
      421 fkgetgnlla fpptfyggak ppsapaasvp cpeptgapea vdgagpeeeq ldtaeiafqv
      481 keqllkhnig qrvfghyvlg lsqgsvseil arpkpwrklt vkgkepfikm kqflsdeqnv
      541 lalrtiqvrq rgsitprirt petgsddaik sileqakkei esqkggeskn spasvsipng
      601 tassstseda iknileqarr emqaqqqall emesgprgrs vppspperps patasqngal
      661 tcvkqedggg gsgssstvqa plavlspaaf vqriirkvks eigdagyfdh hwasdrglls
      721 rpyasvspsl sssssysgqp ngrawprgde atiapedeaa mgedeaprvg elkaeagape
      781 vgggrlpyyp ayvprtlkpt vppltpeqye lymyrevdtl eltrqvkekl akngicqrif
      841 gekvlglsqg svsdmlsrpk pwskltqkgr epfirmqlwl sdqlgqgqgq aptqqpsasq
      901 aspteptssp spppsptepe ktsqeplgls lesskenqqp egrassslgg kpfsssqaag
      961 giqemvamsp eldtysitkr vkevltdnnl gqrlfgesil gltqgsvsdl lsrpkpwhkl
     1021 slkgrepfvr mqlwlsdphn veklrdmkkl ekkaylkrry gligtgsdse spaahsecps
     1081 pclqpqelsl mqakkprvvl apaekealrk ayqlepypsq qtiellsfql nlktntvinw
     1141 fhnyrsrmrr emlvegtqdd pdfdpsggpn vltpghthre ptpqspdset edqkppmksl
     1201 elqepegplq raapdralvk ikqeeglevd gdsqpqdvgd pdrgqdgpke ehthplgnsd
     1261 lselapgpfl sgtpnpdcps lhnpqekgtg eqvhseplsf kstsessccs legppnspsv
     1321 isspdlttcv spapsssapi spslpgappa kvpstsptgd taaalhpstk vnpnlqrrhe
     1381 kmanlnsiiy rleraanree vlewef
//
LOCUS       NP_032677                751 aa            linear   ROD 27-AUG-2025
DEFINITION  myb-related protein A isoform 1 [Mus musculus].
ACCESSION   NP_032677
VERSION     NP_032677.2
DBSOURCE    REFSEQ: accession NM_008651.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Kitamura,Y., Takahashi,K., Maezawa,S., Munakata,Y., Sakashita,A.,
            Katz,S.P., Kaplan,N. and Namekawa,S.H.
  TITLE     CTCF-mediated 3D chromatin sets up the gene expression program in
            the male germline
  JOURNAL   Nat Struct Mol Biol 32 (7), 1227-1240 (2025)
   PUBMED   40033153
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Cecchini,K., Biasini,A., Yu,T., Saflund,M., Mou,H., Arif,A.,
            Eghbali,A., Colpan,C., Gainetdinov,I., de Rooij,D.G., Weng,Z.,
            Zamore,P.D. and Ozata,D.M.
  TITLE     The transcription factor TCFL5 responds to A-MYB to elaborate the
            male meiotic program in mice
  JOURNAL   Reproduction 165 (2), 183-196 (2023)
   PUBMED   36395073
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Xu,J., Wang,B. and Zhang,D.
  TITLE     LncRNA ENSMUST00000171502 Induced by HIF-1alpha Ameliorates
            Ischemic Acute Kidney Injury via Targeting the miR-130b-3p/Mybl-1
            Axis
  JOURNAL   Cells 11 (23), 3747 (2022)
   PUBMED   36497007
  REMARK    GeneRIF: LncRNA ENSMUST00000171502 Induced by HIF-1alpha
            Ameliorates Ischemic Acute Kidney Injury via Targeting the
            miR-130b-3p/Mybl-1 Axis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Yu,T., Biasini,A., Cecchini,K., Saflund,M., Mou,H., Arif,A.,
            Eghbali,A., de Rooij,D., Weng,Z., Zamore,P.D. and Ozata,D.M.
  TITLE     A-MYB/TCFL5 regulatory architecture ensures the production of
            pachytene piRNAs in placental mammals
  JOURNAL   RNA 29 (1), 30-43 (2022)
   PUBMED   36241367
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Maezawa,S., Sakashita,A., Yukawa,M., Chen,X., Takahashi,K.,
            Alavattam,K.G., Nakata,I., Weirauch,M.T., Barski,A. and
            Namekawa,S.H.
  TITLE     Super-enhancer switching drives a burst in gene expression at the
            mitosis-to-meiosis transition
  JOURNAL   Nat Struct Mol Biol 27 (10), 978-988 (2020)
   PUBMED   32895557
  REMARK    GeneRIF: Super-enhancer switching drives a burst in gene expression
            at the mitosis-to-meiosis transition.
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Toscani,A., Mettus,R.V., Coupland,R., Simpkins,H., Litvin,J.,
            Orth,J., Hatton,K.S. and Reddy,E.P.
  TITLE     Arrest of spermatogenesis and defective breast development in mice
            lacking A-myb
  JOURNAL   Nature 386 (6626), 713-717 (1997)
   PUBMED   9109487
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Latham,K.E., Litvin,J., Orth,J.M., Patel,B., Mettus,R. and
            Reddy,E.P.
  TITLE     Temporal patterns of A-myb and B-myb gene expression during testis
            development
  JOURNAL   Oncogene 13 (6), 1161-1168 (1996)
   PUBMED   8808690
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Sitzmann,J., Noben-Trauth,K. and Klempnauer,K.H.
  TITLE     Expression of mouse c-myb during embryonic development
  JOURNAL   Oncogene 11 (11), 2273-2279 (1995)
   PUBMED   8570177
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Trauth,K., Mutschler,B., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Klempnauer,K.H.
  TITLE     Mouse A-myb encodes a trans-activator and is expressed in
            mitotically active cells of the developing central nervous system,
            adult testis and B lymphocytes
  JOURNAL   EMBO J 13 (24), 5994-6005 (1994)
   PUBMED   7813437
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Mettus,R.V., Litvin,J., Wali,A., Toscani,A., Latham,K., Hatton,K.
            and Reddy,E.P.
  TITLE     Murine A-myb: evidence for differential splicing and
            tissue-specific expression
  JOURNAL   Oncogene 9 (10), 3077-3086 (1994)
   PUBMED   8084617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158790.5 and AC103620.12.
            
            On Nov 19, 2006 this sequence version replaced NP_032677.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the same strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103533.1, X82327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 2.08 cM"
     Protein         1..751
                     /product="myb-related protein A isoform 1"
                     /note="myb-related protein A; myb-like protein 1"
                     /calculated_mol_wt=85414
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Region          38..98
                     /region_name="Myb_DNA-bind_6"
                     /note="Myb-like DNA-binding domain; pfam13921"
                     /db_xref="CDD:372817"
     Site            order(38,68..69,71..72,74..76,78..80)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     Region          84..>192
                     /region_name="PLN03091"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:215570"
     Region          230..294
                     /region_name="Transcriptional activation domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Region          240..285
                     /region_name="LMSTEN"
                     /note="LMSTEN motif; pfam07988"
                     /db_xref="CDD:462332"
     Region          297..552
                     /region_name="Negative regulatory domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P51960.2)"
     Site            393
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10243; propagated from
                     UniProtKB/Swiss-Prot (P51960.2)"
     Region          485..641
                     /region_name="Cmyb_C"
                     /note="C-myb, C-terminal; pfam09316"
                     /db_xref="CDD:462753"
     CDS             1..751
                     /gene="Mybl1"
                     /gene_synonym="A-myb; G1-419-6; repro9"
                     /coded_by="NM_008651.3:256..2511"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35510.1"
                     /db_xref="GeneID:17864"
                     /db_xref="MGI:MGI:99925"
ORIGIN      
        1 makrsrsede dddlqyadhd yevpqqkglk klwnrvkwtr deddklkklv eqhgtddwtl
       61 iashlqnrsd fqcqhrwqkv lnpelikgpw tkeedqrvie lvqkygpkrw sliakhlkgr
      121 igkqcrerwh nhlnpevkks swteeedrii yeahkrlgnr waeiakllpg rtdnsiknhw
      181 nstmrrkveq egylqdgiks ersssklqhk pcatmdhlqt qnqfyipvqi pgyqyvspdg
      241 ncvehvqtsa fiqqpfvded pdkekkikel elllmsaene vrrkrlppqp gsfsswsgsf
      301 lmddsmsntl nnleehttef ysmdenqtvs aqqnsptkfl aveanavlss lqtipefaet
      361 leliesdpva wsdvtsfdls daaaspvkst pvklmriqhn egamecqfnv slvlegkkns
      421 rnggdseaip ltspnvvkfs tpptilrkkk rirvgqsags elgdgslsev gnaalkhtpv
      481 ktlpfspsqf fntcpgneql nienpsftst picgqkvlit tplqkeatpk dqkenvgfrt
      541 ptirrsilgt tprtptpfkn alaaqekkyg plkivsqpla fleedirevl keetgtdifl
      601 keedepayks ckqehsasvk kvrkslales wdkeepgtql ltedisdmqs enilttsllm
      661 iplleihdnr cnltpekqdi nsanktytln kkrpnpnpck avklekslqs ncewetvvyg
      721 ktedqlimte qarrylstyt atsstsrali l
//
LOCUS       NP_001258659             371 aa            linear   ROD 27-AUG-2025
DEFINITION  X-box-binding protein 1 isoform XBP1(S) [Mus musculus].
ACCESSION   NP_001258659
VERSION     NP_001258659.1
DBSOURCE    REFSEQ: accession NM_001271730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Touvier,T., Veneri,F.A., Claessens,A., Ferri,C., Mastrangelo,R.,
            Sorgiati,N., Bianchi,F., Valenzano,S., Del Carro,U., Rivellini,C.,
            Duong,P., Shy,M.E., Kelly,J.W., Svaren,J., Wiseman,R.L. and
            D'Antonio,M.
  TITLE     Activation of XBP1s attenuates disease severity in models of
            proteotoxic Charcot-Marie-Tooth type 1B
  JOURNAL   Brain 148 (6), 1978-1993 (2025)
   PUBMED   39979221
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Barton,B.M., Son,F., Verma,A., Bal,S.K., Tang,Q., Wang,R.,
            Umphred-Wilson,K., Khan,R., Trichka,J., Dong,H., Lentucci,C.,
            Chen,X., Chen,Y., Hong,Y., Duy,C., Elemento,O., Melnick,A.M.,
            Cao,J., Chen,X., Glimcher,L.H. and Adoro,S.
  TITLE     IRE1alpha-XBP1 safeguards hematopoietic stem and progenitor cells
            by restricting pro-leukemogenic gene programs
  JOURNAL   Nat Immunol 26 (2), 200-214 (2025)
   PUBMED   39789376
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Reimold,A.M., Etkin,A., Clauss,I., Perkins,A., Friend,D.S.,
            Zhang,J., Horton,H.F., Scott,A., Orkin,S.H., Byrne,M.C.,
            Grusby,M.J. and Glimcher,L.H.
  TITLE     An essential role in liver development for transcription factor
            XBP-1
  JOURNAL   Genes Dev 14 (2), 152-157 (2000)
   PUBMED   10652269
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Masaki,T., Yoshida,M. and Noguchi,S.
  TITLE     Targeted disruption of CRE-binding factor TREB5 gene leads to
            cellular necrosis in cardiac myocytes at the embryonic stage
  JOURNAL   Biochem Biophys Res Commun 261 (2), 350-356 (1999)
   PUBMED   10425189
REFERENCE   8  (residues 1 to 371)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Clauss,I.M., Chu,M., Zhao,J.L. and Glimcher,L.H.
  TITLE     The basic domain/leucine zipper protein hXBP-1 preferentially binds
            to and transactivates CRE-like sequences containing an ACGT core
  JOURNAL   Nucleic Acids Res 24 (10), 1855-1864 (1996)
   PUBMED   8657566
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Clauss,I.M., Gravallese,E.M., Darling,J.M., Shapiro,F.,
            Glimcher,M.J. and Glimcher,L.H.
  TITLE     In situ hybridization studies suggest a role for the basic
            region-leucine zipper protein hXBP-1 in exocrine gland and skeletal
            development during mouse embryogenesis
  JOURNAL   Dev Dyn 197 (2), 146-156 (1993)
   PUBMED   7693055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662876.23, BG800705.1 and BF453945.1.
            
            Transcript Variant: This variant (2) lacks a 26 nt segment in the
            CDS compared to variant 1, that causes a frameshift. The resulting
            isoform, XBP1(S), has the same N-terminus, but a longer and
            distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S)
            functions as a transcription factor.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF443192.1, CF616395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.61 cM"
     Protein         1..371
                     /product="X-box-binding protein 1 isoform XBP1(S)"
                     /note="tax-responsive element-binding protein 5 homolog"
                     /calculated_mol_wt=39757
     Region          35..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17861; propagated from
                     UniProtKB/Swiss-Prot (O35426.2)"
     Region          63..119
                     /region_name="bZIP_XBP1"
                     /note="Basic leucine zipper (bZIP) domain of X-box binding
                     protein 1 (XBP1) and similar proteins: a DNA-binding and
                     dimerization domain; cd14691"
                     /db_xref="CDD:269839"
     Region          65..87
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Region          66..117
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269839"
     Region          69..85
                     /region_name="Nuclear localization signal (NLS).
                     /evidence=ECO:0000250|UniProtKB:P17861"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     Site            order(69..70,72..74,76..81,83..85)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269839"
     Site            order(84,87..88,91..92,94..95,98..99,101..102,105..106,
                     108..109,112..113,115..116)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269839"
     Region          91..126
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O35426.2)"
     CDS             1..371
                     /gene="Xbp1"
                     /gene_synonym="D11Ertd39e; TREB-5; TREB5; XBP-1"
                     /coded_by="NM_001271730.1:355..1470"
                     /note="isoform XBP1(S) is encoded by transcript variant 2"
                     /db_xref="GeneID:22433"
                     /db_xref="MGI:MGI:98970"
ORIGIN      
        1 mvvvaaapsa ataapkvlll sgqpasggra lplmvpgpra agseasgtpq arkrqrlthl
       61 speekalrrk lknrvaaqta rdrkkarmse leqqvvdlee enhklqlenq llrekthglv
      121 venqelrtrl gmdtldpdev peveakgsgv rlvagsaesa agagpvvtsp ehlpmdsdtv
      181 assdsesdil lgildkldpv mffkcpspes asleelpevy pegpsslpas lslsvgtssa
      241 kleainelir fdhvytkplv leipsetesq tnvvvkieea plssseedhp efivsvkkep
      301 leddfipelg isnllssshc lrppscllda hsdcgyegsp spfsdmsspl gtdhswedtf
      361 anelfpqlis v
//
LOCUS       NP_001342651             931 aa            linear   ROD 27-AUG-2025
DEFINITION  adhesion G protein-coupled receptor E1 isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_001342651 XP_006523664
VERSION     NP_001342651.1
DBSOURCE    REFSEQ: accession NM_001355722.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 931)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 931)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 931)
  AUTHORS   Kashimada,A., Mizuno,T., Tanaka,E., Hosokawa,S., Udagawa,T.,
            Hiraoka,Y., Uchida,K., Morio,T., Kosaki,K. and Takagi,M.
  TITLE     De novo variant in RING finger protein 213 causes systemic
            vasculopathy
  JOURNAL   JCI Insight 10 (11), e190094 (2025)
   PUBMED   40485582
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 931)
  AUTHORS   Weinhaus,B., Homan,S., Kincaid,M., Tadwalkar,A., Gu,X., Kumar,S.,
            Slaughter,A., Zhang,J., Wu,Q., Kofron,J.M., Troutman,T.D.,
            DeFalco,T. and Lucas,D.
  TITLE     Differential regulation of fetal bone marrow and liver
            hematopoiesis by yolk-sac-derived myeloid cells
  JOURNAL   Nat Commun 16 (1), 4427 (2025)
   PUBMED   40368906
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 931)
  AUTHORS   Hu,B., Liu,X., Xiong,S., Gong,Q., Yang,J., Shi,H., Zhang,M.,
            Liang,F. and Zhang,Z.
  TITLE     Increased cardiac macrophages in Sorbs2-deficient hearts: revealing
            a potential role for macrophage in responding to embryonic
            myocardial abnormalities
  JOURNAL   Front Genet 15, 1525931 (2025)
   PUBMED   39882075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 931)
  AUTHORS   McKnight,A.J. and Gordon,S.
  TITLE     EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte
            cell-surface molecules
  JOURNAL   Immunol Today 17 (6), 283-287 (1996)
   PUBMED   8962632
  REMARK    Review article
REFERENCE   7  (residues 1 to 931)
  AUTHORS   Luciani,M.F. and Chimini,G.
  TITLE     The ATP binding cassette transporter ABC1, is required for the
            engulfment of corpses generated by apoptotic cell death
  JOURNAL   EMBO J 15 (2), 226-235 (1996)
   PUBMED   8617198
REFERENCE   8  (residues 1 to 931)
  AUTHORS   McKnight,A.J., Macfarlane,A.J., Dri,P., Turley,L., Willis,A.C. and
            Gordon,S.
  TITLE     Molecular cloning of F4/80, a murine macrophage-restricted cell
            surface glycoprotein with homology to the G-protein-linked
            transmembrane 7 hormone receptor family
  JOURNAL   J Biol Chem 271 (1), 486-489 (1996)
   PUBMED   8550607
REFERENCE   9  (residues 1 to 931)
  AUTHORS   Timsit,S., Martinez,S., Allinquant,B., Peyron,F., Puelles,L. and
            Zalc,B.
  TITLE     Oligodendrocytes originate in a restricted zone of the embryonic
            ventral neural tube defined by DM-20 mRNA expression
  JOURNAL   J Neurosci 15 (2), 1012-1024 (1995)
   PUBMED   7869079
REFERENCE   10 (residues 1 to 931)
  AUTHORS   Chen,H.L., Kamath,R., Pace,J.L., Russell,S.W. and Hunt,J.S.
  TITLE     Gestation-related expression of the interferon-gamma receptor gene
            in mouse uterine and embryonic hematopoietic cells
  JOURNAL   J Leukoc Biol 55 (5), 617-625 (1994)
   PUBMED   8182339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010434.8.
            
            On Sep 26, 2017 this sequence version replaced XP_006523664.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.8 cM"
     Protein         1..931
                     /product="adhesion G protein-coupled receptor E1 isoform 1
                     precursor"
                     /note="EGF-like module-containing mucin-like hormone
                     receptor-like 1; cell surface glycoprotein F4/80; EMR1
                     hormone receptor; EGF-like module receptor 1; EGF-like
                     module containing, mucin-like, hormone receptor-like
                     sequence 1"
                     /calculated_mol_wt=98893
     sig_peptide     1..27
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
                     /calculated_mol_wt=3256
     mat_peptide     28..931
                     /product="Adhesion G protein-coupled receptor E1.
                     /id=PRO_0000012874"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
                     /calculated_mol_wt=98893
     Region          33..63
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          81..115
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(81,84,100)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          133..172
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(133,136,151)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            148
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          173..>203
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(173,176,191)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          222..258
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(222,225,241)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            229
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            269
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          272..>301
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(272,275,288)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            283
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          319..352
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(319,322,338)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            405
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            417
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            474
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Site            498
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          506..508
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          591..640
                     /region_name="GPS"
                     /note="G-protein-coupled receptor proteolytic site domain;
                     smart00303"
                     /db_xref="CDD:197639"
     Region          595..642
                     /region_name="GPS.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00098"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          644..906
                     /region_name="7tmB2_EMR"
                     /note="epidermal growth factor-like module-containing
                     mucin-like hormone receptors, member of the class B2
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15439"
                     /db_xref="CDD:320555"
     Site            645..672
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          646..671
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320555"
     Site            order(651,655,697,700..701,704,711,718,795..796,798,800,
                     856,859,871,875)
                     /site_type="other"
                     /note="putative polypeptide ligand binding pocket
                     [polypeptide binding]"
                     /db_xref="CDD:320555"
     Region          680..702
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320555"
     Site            680..701
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Site            706
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61549.1)"
     Region          711..738
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320555"
     Site            712..735
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Site            755..776
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          755..775
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320555"
     Region          792..815
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320555"
     Site            793..821
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          839..864
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320555"
     Site            840..859
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     Region          868..893
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320555"
     Site            875..897
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61549.1)"
     CDS             1..931
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /coded_by="NM_001355722.2:27..2822"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS50160.1"
                     /db_xref="GeneID:13733"
                     /db_xref="MGI:MGI:106912"
ORIGIN      
        1 mwgfwlllfw gfsgmyrwgm ttlptlgqtl ggvnecqdtt tcpayatctd ttdsyyctck
       61 rgflssngqt nfqgpgvecq dvneclqsds pcgpnsvctn ilgrakcscl rgfssstgkd
      121 wilgsldnfl cadvdeclti gicpkysncs nsvgsysctc qpgfvlngsi cededecvtr
      181 dvcpehatch ntlgsyyctc nsglessggg pmfqgldesc edvdecsrns tlcgptfici
      241 ntlgsyscsc pagfslptfq ilghpadgnc tdidecddtc plnssctnti gsyfctchpg
      301 fassngqlnf kdlevtcedi dectqdplqc glnsvctnvp gsyicgclpd fqmdpegsqg
      361 ygnfnckril fkckedlilq seqiqqcqav qgrdlgyasf ctlvnatfti ldntcenksa
      421 pvslqsaats vslvleqatt wfelskeets tlgtilletv estmlaalli psgnasqmiq
      481 teyldieskv ineeckenes inlaargdkm nvgcfiikes vstgapgvaf vsfahmesvl
      541 nerffedgqs frklrmnsrv vggtvtgekk edfskpiiyt lqhiqpkqks erpicvswnt
      601 dvedgrwtps gceiveaset htvcscnrma nlaiimasge ltmefslyii shvgtvislv
      661 clalaiatfl lcravqnhnt ymhlhlcvcl flakilfltg idktdnqtac aiiagflhyl
      721 flacffwmlv eavmlflmvr nlkvvnyfss rnikmlhlca fgyglpvlvv iisasvqprg
      781 ygmhnrcwln tetgfiwsfl gpvcmiitin svllawtlwv lrqklcsvss evsklkdtrl
      841 ltfkaiaqif ilgcswvlgi fqigplasim aylftiinsl qgafiflihc llnrqvrdey
      901 kklltrktdl sshsqtsgil lssmpstskm g
//
LOCUS       NP_001070657             340 aa            linear   ROD 27-AUG-2025
DEFINITION  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1
            precursor [Mus musculus].
ACCESSION   NP_001070657
VERSION     NP_001070657.1
DBSOURCE    REFSEQ: accession NM_001077189.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 340)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 340)
  AUTHORS   Bennion,K.B., Miranda R Bazzano,J., Liu,D., Wagener,M., Paulos,C.M.
            and Ford,M.L.
  TITLE     Macrophage-derived Fgl2 dampens antitumor immunity through
            regulation of FcgammaRIIB+CD8+ T cells in melanoma
  JOURNAL   JCI Insight 10 (6), e182563 (2025)
   PUBMED   40125553
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 340)
  AUTHORS   Santana,S., Papillion,A., Foote,J.B., Bachus,H., Leon,B., De
            Miguel,C. and Ballesteros-Tato,A.
  TITLE     Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents
            Autoantibody Responses in Systemic Lupus Erythematosus via
            Regulatory T Cell-independent Depletion of T Follicular Helper
            Cells
  JOURNAL   J Immunol 213 (8), 1053-1060 (2024)
   PUBMED   39195194
REFERENCE   4  (residues 1 to 340)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   5  (residues 1 to 340)
  AUTHORS   Bennion,K.B., Liu,D., Dawood,A.S., Wyatt,M.M., Alexander,K.L.,
            Abdel-Hakeem,M.S., Paulos,C.M. and Ford,M.L.
  TITLE     CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous
            manner via ligation of FcgammaRIIB
  JOURNAL   Nat Commun 15 (1), 5280 (2024)
   PUBMED   38902261
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 340)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (residues 1 to 340)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (residues 1 to 340)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (residues 1 to 340)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (residues 1 to 340)
  AUTHORS   Dickles,H.B., Ahmed,A. and Sachs,D.H.
  TITLE     B-lymphocyte Fc receptor-associated non-H-2 antigens are determined
            by a single polymorphic locus which is linked to the Mls locus
  JOURNAL   J Exp Med 146 (6), 1678-1692 (1977)
   PUBMED   303687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115959.17.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171316.1, AK155329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.02 cM"
     Protein         1..340
                     /product="low affinity immunoglobulin gamma Fc region
                     receptor II-b isoform 1 precursor"
                     /note="low affinity immunoglobulin gamma Fc region
                     receptor II; fc-gamma RII; fc-gamma-RIIB; fc gamma
                     receptor IIB; lymphocyte antigen 17; igG Fc receptor II
                     beta; Fc-gamma-RII; Fc gamma RIIB; FcgammaRIIB; low
                     affinity immunoglobulin gamma Fc region receptor II-b"
                     /calculated_mol_wt=33412
     sig_peptide     1..39
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4397
     Region          46..124
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          63..67
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          77..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          92..96
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          106..111
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          117..120
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          128..210
                     /region_name="Ig2_FcgammaR_like"
                     /note="Second immunoglobulin (Ig)-like domain of
                     Fcgamma-receptors (FcgammaRs), and similar domains;
                     cd05753"
                     /db_xref="CDD:409411"
     Site            order(128,151,157..158)
                     /site_type="other"
                     /note="Fc binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          128..132
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409411"
     Region          137..139
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409411"
     Site            order(141..143,152,157,196)
                     /site_type="other"
                     /note="pentraxin binding site [polypeptide binding]"
                     /db_xref="CDD:409411"
     Region          143..150
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409411"
     Region          157..163
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409411"
     Region          166..171
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409411"
     Region          175..179
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409411"
     Region          189..194
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409411"
     Region          200..210
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409411"
     CDS             1..340
                     /gene="Fcgr2b"
                     /gene_synonym="CD32; F630109E10Rik; Fcgr2; Fcgr2a; FcgRII;
                     Fcr-2; Fcr-3; fcRII; Fc[g]RII; Ly-17; Ly-m20; Lym-1;
                     LyM-1"
                     /coded_by="NM_001077189.2:81..1103"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS35770.1"
                     /db_xref="GeneID:14130"
                     /db_xref="MGI:MGI:95499"
ORIGIN      
        1 mgilpfllip mesnwtvhvf srtlchmllw tavlnlaagt hdlpkavvkl eppwiqvlke
       61 dtvtltcegt hnpgnsstqw fhngrsirsq vqasytfkat vndsgeyrcq meqtrlsdpv
      121 dlgvisdwll lqtpqlvfle getitlrchs wrnkllnris ffhneksvry hhyssnfsip
      181 kanhshsgdy yckgslgrtl hqskpvtitv qgpkssrslp vltivaavtg iavaaiviil
      241 vslvylkkkq vpalpgnpdh remgetlpee vgeyrqpsgg svpvspgpps gleptssspy
      301 nppdleeaak teaentitys llkhpealde etehdyqnhi
//
LOCUS       NP_001288161             221 aa            linear   ROD 27-AUG-2025
DEFINITION  ras-related protein Rab-27A [Mus musculus].
ACCESSION   NP_001288161 XP_006510845
VERSION     NP_001288161.1
DBSOURCE    REFSEQ: accession NM_001301232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 221)
  AUTHORS   Chen,R., Powell,J.S., Shufesky,W.J., Bardhi,E., Sullivan,M.L.G.,
            Tkacheva,O.A., Camirand,G., Goncalves,Z., Stolz,D.B., Chalasani,G.,
            Catz,S.D., Watkins,S.C., Larregina,A.T. and Morelli,A.E.
  TITLE     Transplants foster B cell alloimmunity by relaying extracellular
            vesicles to follicular dendritic cells
  JOURNAL   Cell Rep 44 (6), 115832 (2025)
   PUBMED   40516053
REFERENCE   2  (residues 1 to 221)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 221)
  AUTHORS   Li,X., Qiao,F., Guo,J., Jiang,T., Lou,H., Li,H., Xie,G., Wu,H.,
            Wang,W., Pei,R., Liu,S., Ye,M., Li,J., Huang,S., Zhang,M., Ma,C.,
            Huang,Y., Xu,S., Li,X., Sun,X., Yu,J., Fok,K.L., Duan,S. and
            Chen,H.
  TITLE     In situ architecture of the intercellular organelle reservoir
            between epididymal epithelial cells by volume electron microscopy
  JOURNAL   Nat Commun 16 (1), 1664 (2025)
   PUBMED   39955273
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 221)
  AUTHORS   Gu,J., Chen,X., Luo,Z., Li,R., Xu,Q., Liu,M., Liu,X., Liu,Y.,
            Jiang,S., Zou,M., Ling,S., Liu,S. and Liu,N.
  TITLE     Cardiomyocyte-derived exosomes promote cardiomyocyte proliferation
            and neonatal heart regeneration
  JOURNAL   FASEB J 38 (22), e70186 (2024)
   PUBMED   39560071
REFERENCE   5  (residues 1 to 221)
  AUTHORS   Munafo,D.B., Johnson,J.L., Ellis,B.A., Rutschmann,S., Beutler,B.
            and Catz,S.D.
  TITLE     Rab27a is a key component of the secretory machinery of azurophilic
            granules in granulocytes
  JOURNAL   Biochem J 402 (2), 229-239 (2007)
   PUBMED   17090228
  REMARK    GeneRIF: Rab27a and JFC1/Slp1 permit myeloperoxidase release into
            the surrounding milieu and constitute key components of the
            secretory machinery of azurophilic granules in granulocytes
REFERENCE   6  (residues 1 to 221)
  AUTHORS   Barral,D.C., Ramalho,J.S., Anders,R., Hume,A.N., Knapton,H.J.,
            Tolmachova,T., Collinson,L.M., Goulding,D., Authi,K.S. and
            Seabra,M.C.
  TITLE     Functional redundancy of Rab27 proteins and the pathogenesis of
            Griscelli syndrome
  JOURNAL   J Clin Invest 110 (2), 247-257 (2002)
   PUBMED   12122117
  REMARK    GeneRIF: Rab27b is functionally redundant with Rab27a and the
            pathogenesis of Griscelli syndrome is determined by the relative
            expression of Rab27a and Rab27b in specialized cell types.
            Erratum:[J Clin Invest 2002 Oct;110(8):1213]
REFERENCE   7  (residues 1 to 221)
  AUTHORS   Wilson,S.M., Yip,R., Swing,D.A., O'Sullivan,T.N., Zhang,Y.,
            Novak,E.K., Swank,R.T., Russell,L.B., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A mutation in Rab27a causes the vesicle transport defects observed
            in ashen mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7933-7938 (2000)
   PUBMED   10859366
REFERENCE   8  (residues 1 to 221)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (residues 1 to 221)
  AUTHORS   Moore,K.J., Swing,D.A., Rinchik,E.M., Mucenski,M.L., Buchberg,A.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene dsu suppresses the coat-color
            phenotype of three pigment mutations that alter melanocyte
            morphology, d, ash and ln
  JOURNAL   Genetics 119 (4), 933-941 (1988)
   PUBMED   3410303
REFERENCE   10 (residues 1 to 221)
  AUTHORS   Langdon,W.Y., Theodore,T.S., Buckler,C.E., Stimpfling,J.H.,
            Martin,M.A. and Morse,H.C. 3rd.
  TITLE     Relationship between a retroviral germ line reintegration and a new
            mutation at the ashen locus in B10.F mice. Retroviral integration
            and an ashen mutation
  JOURNAL   Virology 133 (1), 183-190 (1984)
   PUBMED   6322428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157513.2, BB857060.1,
            CV784419.1, AK010373.1, AK008798.1, BE948607.1 and BP769437.1.
            
            On Jul 29, 2014 this sequence version replaced XP_006510845.1.
            
            Summary: The protein encoded by this gene is a member of the Rab
            family of proteins, which is the largest family within the Ras
            superfamily of GTPases. This gene product is thought to regulate
            vesicular transport, together with its specific effectors.
            Mutations in this gene cause several defects, including actin-based
            melanosome transport defects and immunodeficiency. Mutations in the
            human ortholog of this gene are associated with Griscelli syndrome
            type 2. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            represents use of an alternate promoter, compared to variant 1.
            Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.696318.1, CV784419.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     Protein         1..221
                     /product="ras-related protein Rab-27A"
                     /EC_number="3.6.5.2"
                     /note="ashen"
                     /calculated_mol_wt=24886
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P51159; propagated from
                     UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51159; propagated from
                     UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Region          6..185
                     /region_name="Rab27A"
                     /note="Rab GTPase family 27a (Rab27a); cd04127"
                     /db_xref="CDD:206700"
     Site            6..11
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206700"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206700"
     Site            order(19..24,134,136,164..165)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206700"
     Site            order(24..34,39..40)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206700"
     Site            order(34,39..47)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206700"
     Region          38..46
                     /region_name="Effector region. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Site            order(39,43..50,67,69)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206700"
     Site            order(42,44..46,71,73,80..81,84,88,90..93)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206700"
     Site            order(42..43,45,73..74,81,83,85..87)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            42..46
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206700"
     Site            69..73
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206700"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206700"
     Site            order(77,79..89)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206700"
     Site            80..85
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206700"
     Site            88..92
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206700"
     Site            97..102
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206700"
     Site            120..130
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206700"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206700"
     Site            163..165
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206700"
     Site            179..185
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206700"
     Site            221
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9ERI2.1)"
     CDS             1..221
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /coded_by="NM_001301232.1:267..932"
                     /db_xref="CCDS:CCDS23335.1"
                     /db_xref="GeneID:11891"
                     /db_xref="MGI:MGI:1861441"
ORIGIN      
        1 msdgdydyli kflalgdsgv gktsvlyqyt dgkfnskfit tvgidfrekr vvyrangpdg
       61 avgrgqrihl qlwdtagqer frslttaffr damgflllfd ltneqsflnv rnwisqlqmh
      121 aycenpdivl cgnksdledq ravkeeeare laekygipyf etsaangtni shaiemlldl
      181 imkrmercvd kswipegvvr snghtsadql seekekglcg c
//
LOCUS       NP_001123649             298 aa            linear   ROD 27-AUG-2025
DEFINITION  troponin T, cardiac muscle isoform c [Mus musculus].
ACCESSION   NP_001123649
VERSION     NP_001123649.1
DBSOURCE    REFSEQ: accession NM_001130177.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 298)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 298)
  AUTHORS   Lin,S., Dieterich,C., Britto-Borges,T., Gunther,S., Kreher,S.,
            Eibach,Y., Kuenne,C., Schneider,A. and Braun,T.
  TITLE     Rbpms2 prevents major cardiac defects in cardiomyocyte-specific
            Rbpms-deficient mice
  JOURNAL   Dev Cell (2025) In press
   PUBMED   40602408
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 298)
  AUTHORS   Abukar,S., Embacher,P.A., Ciccarelli,A., Varsani-Brown,S.,
            North,I.G.W., Dean,J.A., Briscoe,J. and Ivanovitch,K.
  TITLE     Early coordination of cell migration and cardiac fate determination
            during mammalian gastrulation
  JOURNAL   EMBO J 44 (12), 3327-3359 (2025)
   PUBMED   40360834
REFERENCE   4  (residues 1 to 298)
  AUTHORS   Abraham,E., Kostina,A., Volmert,B., Roule,T., Huang,L., Yu,J.,
            Williams,A.E., Megill,E., Douglas,A., Pericak,O.M., Morris,A.,
            Stronati,E., Larrinaga-Zamanillo,A., Fueyo,R., Zubillaga,M.,
            Andrake,M.D., Akizu,N., Aguirre,A. and Estaras,C.
  TITLE     A retinoic acid:YAP1 signaling axis controls atrial lineage
            commitment
  JOURNAL   Cell Rep 44 (5), 115687 (2025)
   PUBMED   40343798
REFERENCE   5  (residues 1 to 298)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 298)
  AUTHORS   Wang,D.Z., Reiter,R.S., Lin,J.L., Wang,Q., Williams,H.S.,
            Krob,S.L., Schultheiss,T.M., Evans,S. and Lin,J.J.
  TITLE     Requirement of a novel gene, Xin, in cardiac morphogenesis
  JOURNAL   Development 126 (6), 1281-1294 (1999)
   PUBMED   10021346
REFERENCE   7  (residues 1 to 298)
  AUTHORS   Tardiff,J.C., Factor,S.M., Tompkins,B.D., Hewett,T.E., Palmer,B.M.,
            Moore,R.L., Schwartz,S., Robbins,J. and Leinwand,L.A.
  TITLE     A truncated cardiac troponin T molecule in transgenic mice suggests
            multiple cellular mechanisms for familial hypertrophic
            cardiomyopathy
  JOURNAL   J Clin Invest 101 (12), 2800-2811 (1998)
   PUBMED   9637714
REFERENCE   8  (residues 1 to 298)
  AUTHORS   Jin,J.P., Wang,J. and Zhang,J.
  TITLE     Expression of cDNAs encoding mouse cardiac troponin T isoforms:
            characterization of a large sample of independent clones
  JOURNAL   Gene 168 (2), 217-221 (1996)
   PUBMED   8654947
REFERENCE   9  (residues 1 to 298)
  AUTHORS   Jin,J.P., Zhang,J. and Wang,J.
  TITLE     An embryonic alternative transcription initiation site and the
            5'-upstream structure of mouse cardiac troponin T gene
  JOURNAL   Biochem Biophys Res Commun 214 (3), 1168-1174 (1995)
   PUBMED   7575526
REFERENCE   10 (residues 1 to 298)
  AUTHORS   Chen,Z., Friedrich,G.A. and Soriano,P.
  TITLE     Transcriptional enhancer factor 1 disruption by a retroviral gene
            trap leads to heart defects and embryonic lethality in mice
  JOURNAL   Genes Dev 8 (19), 2293-2301 (1994)
   PUBMED   7958896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162441.11, AK163786.1 and AK168393.1.
            
            Transcript Variant: This variant (4) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. The resulting
            isoform (c) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.32 cM"
     Protein         1..298
                     /product="troponin T, cardiac muscle isoform c"
                     /note="troponin T, cardiac muscle; tnTc; cardiac muscle
                     troponin T; cardiac TnT"
                     /calculated_mol_wt=35367
     Region          1..97
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P50752.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P09741; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P13789; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     Region          106..241
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     Site            204
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCA.
                     /evidence=ECO:0000269|PubMed:12832403; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     Site            208
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCA.
                     /evidence=ECO:0000269|PubMed:12832403; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCA and RAF1.
                     /evidence=ECO:0000305|PubMed:12832403; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     Region          216..>283
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCA.
                     /evidence=ECO:0000269|PubMed:12832403; propagated from
                     UniProtKB/Swiss-Prot (P50752.2)"
     CDS             1..298
                     /gene="Tnnt2"
                     /gene_synonym="cTnT; Tnt"
                     /coded_by="NM_001130177.2:128..1024"
                     /note="isoform c is encoded by transcript variant 4"
                     /db_xref="GeneID:21956"
                     /db_xref="MGI:MGI:104597"
ORIGIN      
        1 msdaeevvee yeeeqeeedw seeeedeqee aveeeeagga epepegeaet eeanveevgp
       61 deeakdaeeg pvedtkpkps rlfmpnlvpp kipdgervdf ddihrkrvek dlnelqtlie
      121 ahfenrkkee eelislkdri ekrraeraeq qrirnereke rqnrlaeera rreeeenrrk
      181 aedearkkka lsnmmhfggy iqkterksgk rqterekkkk ilaerrkala idhlnedqlr
      241 ekakelwqsi hnleaekfdl qekfkqqkye invlrnrind nqkvsktrgk akvtgrwk
//
LOCUS       NP_001348536            1935 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin-7 [Mus musculus].
ACCESSION   NP_001348536
VERSION     NP_001348536.1
DBSOURCE    REFSEQ: accession NM_001361607.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1935)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 1935)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1935)
  AUTHORS   Monteiro,J.P., Saha,D., Spiroski,A.M., Mahesh,S., Kaltzis,P.,
            Nadavallil,A., Janbandhu,V., Murray,N.J., Severi,F., De Pace,A.L.,
            Sanchez-Esteban,S., Rodor,J., Beqqali,A., Bennett,M., Stewart,K.,
            Thomson,A., Hadoke,P.W.F., Markose,D., Wilson-Kanamori,J.R.,
            Henderson,N.C., O'Carroll,D., Quertermous,T., Harvey,R.P., Del
            Monte-Nieto,G. and Baker,A.H.
  TITLE     Loss of conserved long non-coding RNA MIR503HG leads to altered
            NOTCH pathway signalling and left ventricular non-compaction
            cardiomyopathy
  JOURNAL   Cardiovasc Res 121 (7), 988-991 (2025)
   PUBMED   40183391
REFERENCE   4  (residues 1 to 1935)
  AUTHORS   Shi,H., Li,J., Li,F., Yu,H., Zhang,F., Wu,T., Yang,L., Li,Y.,
            Hu,R., Chen,M., Sg,N., Zhuang,X., Feng,S., Zhu,L. and Duan,R.
  TITLE     Vitamin C-Dependent Intergenerational Inheritance of Enhanced
            Endurance Performance Following Maternal Exercise
  JOURNAL   Adv Sci (Weinh) 12 (13), e2408912 (2025)
   PUBMED   39921869
REFERENCE   5  (residues 1 to 1935)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Lu,Y., Liu,E.,
            Kim,I.M., Jiao,K., Weintraub,N.L., Zhou,J., Li,J. and Su,H.
  TITLE     Neddylation drives myofibrillogenesis in the developing heart
  JOURNAL   FASEB J 38 (24), e70260 (2024)
   PUBMED   39698930
REFERENCE   6  (residues 1 to 1935)
  AUTHORS   Watkins,H., Rosenzweig,A., Hwang,D.S., Levi,T., McKenna,W.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Characteristics and prognostic implications of myosin missense
            mutations in familial hypertrophic cardiomyopathy
  JOURNAL   N Engl J Med 326 (17), 1108-1114 (1992)
   PUBMED   1552912
REFERENCE   7  (residues 1 to 1935)
  AUTHORS   Parker-Thornburg,J., Bauer,B., Palermo,J. and Robbins,J.
  TITLE     Structural and developmental analysis of two linked myosin heavy
            chain genes
  JOURNAL   Dev Biol 150 (1), 99-107 (1992)
   PUBMED   1371481
REFERENCE   8  (residues 1 to 1935)
  AUTHORS   Smith,T.H. and Miller,J.B.
  TITLE     Distinct myogenic programs of embryonic and fetal mouse muscle
            cells: expression of the perinatal myosin heavy chain isoform in
            vitro
  JOURNAL   Dev Biol 149 (1), 16-26 (1992)
   PUBMED   1728586
REFERENCE   9  (residues 1 to 1935)
  AUTHORS   Sanchez,A., Jones,W.K., Gulick,J., Doetschman,T. and Robbins,J.
  TITLE     Myosin heavy chain gene expression in mouse embryoid bodies. An in
            vitro developmental study
  JOURNAL   J Biol Chem 266 (33), 22419-22426 (1991)
   PUBMED   1939265
REFERENCE   10 (residues 1 to 1935)
  AUTHORS   Robbins,J., Gulick,J., Sanchez,A., Howles,P. and Doetschman,T.
  TITLE     Mouse embryonic stem cells express the cardiac myosin heavy chain
            genes during development in vitro
  JOURNAL   J Biol Chem 265 (20), 11905-11909 (1990)
   PUBMED   1694848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025533.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158070.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.01 cM"
     Protein         1..1935
                     /product="myosin-7"
                     /note="myosin heavy chain 7; myosin heavy chain, cardiac
                     muscle, fetal"
                     /calculated_mol_wt=222749
     Region          37..1432
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          99..766
                     /region_name="MYSc_class_II"
                     /note="class II myosins, motor domain; cd01377"
                     /db_xref="CDD:276951"
     Site            order(126..134,178..185,233..243,461..466)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276951"
     Site            126..134
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276951"
     Site            129
                     /site_type="methylation"
                     /note="N6,N6,N6-trimethyllysine. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            178..185
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276951"
     Site            233..243
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276951"
     Site            378
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            461..466
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276951"
     Site            490..513
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276951"
     Region          655..677
                     /region_name="Actin-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            697..706
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276951"
     Site            order(709..725,755..766)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276951"
     Region          757..771
                     /region_name="Actin-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Region          1173..1930
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            1269
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q02566; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1282
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1308
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1309
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1510
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02564; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Site            1513
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02563; propagated from
                     UniProtKB/Swiss-Prot (Q91Z83.1)"
     Region          1915..1935
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91Z83.1)"
     CDS             1..1935
                     /gene="Myh7"
                     /gene_synonym="B-MHC; beta-MHC; betaMHC; MYH-beta/slow;
                     Myhc-b; myHC-beta; MyHC-I; myHC-slow; Myhcb"
                     /coded_by="NM_001361607.1:397..6204"
                     /db_xref="CCDS:CCDS27106.1"
                     /db_xref="GeneID:140781"
                     /db_xref="MGI:MGI:2155600"
ORIGIN      
        1 madaemaafg aaapflrkse kerleaqtrp fdlkkdvfvp ddkeefvkak ivsreggkvt
       61 aetengktvt vkedqvmqqn ppkfdkiedm amltflhepa vlynlkerya swmiytysgl
      121 fcvtvnpykw lpvynaevva ayrgkkrsea pphifsisdn ayqymltdre nqsilitges
      181 gagktvntkr viqyfaviaa igdrskkdqt pgkgtledqi iqanpaleaf gnaktvrndn
      241 ssrfgkfiri hfgatgklas adietyllek srvifqlkae rdyhifyqil snkkpelldm
      301 llitnnpydy afisqgettv asiddseelm atdsafdvlg ftpeeknsiy kltgaimhfg
      361 nmkfkqkqre eqaepdgtee adksaylmgl nsadllkglc hprvkvgney vtkgqnvqqv
      421 syaigalaks vyekmfnwmv trinatletk qprqyfigvl diagfeifdf nsfeqlcinf
      481 tneklqqffn hhmfvleqee ykkegiewtf idfgmdlqac idliekpmgi msileeecmf
      541 pkatdmtfka klydnhlgks nnfqkprnvk gkqeahfslv hyagtvdyni lgwlqknkdp
      601 lnetvvglyq ksslkllsnl fanyagadap adkgkgkakk gssfqtvsal hrenlnklmt
      661 nlrsthphfv rciipnetks pgvmdnplvm hqlrcngvle giricrkgfp nrilygdfrq
      721 ryrilnpaai pegqfidsrk gaekllgsld idhnqykfgh tkvffkagll glleemrder
      781 lsriitriqa qsrgvlsrme fkkllerrds lliiqwnira fmgvknwpwm klyfkikpll
      841 ksaetekema tmkeefgrvk daleksearr keleekmvsl lqekndlqlq vqaeqdnlad
      901 aeercdqlik nkiqleakvk emterledee emnaeltakk rkledecsel krdiddlelt
      961 lakvekekha tenkvknlte emagldeiiv kltkekkalq eahqqalddl qaeedkvntl
     1021 tkakvkleqq vddlegsleq ekkvrmdler akrklegdlk ltqesimdle ndkqqlderl
     1081 kkkdfelnal nariedeqal gsqlqkklke lqarieelee eleaertara kveklrsdls
     1141 releeiserl eeaggatsvq iemnkkreae fqkmrrdlee atlqheataa alrkkhadsv
     1201 aelgeqidnl qrvkqkleke ksefkleldd vtsnmeqiik akanlekmcr tledqmnehr
     1261 skaeetqrsv ndltsqrakl qtengelsrq ldekealisq ltrgkltytq qledlkrqle
     1321 eevkaknala halqsarhdc dllreqyeee teakaelqrv lskansevaq wrtkyetdai
     1381 qrteeleeak kklaqrlqda eeaveavnak csslektkhr lqneiedlmv dversnaaaa
     1441 aldkkqrnfd kilaewkqky eesqseless qkearslste lfklknayee slehletfkr
     1501 enknlqeeis dlteqlgstg ksihelekir kqleaeklel qsaleeaeas leheegkilr
     1561 aqlefnqika eierklaekd eemeqakrnh lrmvdslqts ldaetrsrne alrvkkkmeg
     1621 dlnemeiqls hanrmaaeaq kqvkslqsll kdtqiqldda vranddlken iaiverrnnl
     1681 lqaeleelra vveqtersrk laeqeliets ervqllhsqn tslinqkkkm dadlsqlqte
     1741 veeavqecrn aeekakkait daammaeelk keqdtsahle rmkknmeqti kdlqhrldea
     1801 eqialkggkk qlqklearvr eleneleaeq krnaesvkgm rkserrikel tyqteedrkn
     1861 llrlqdlvdk lqlkvkaykr qaeeaeeqan tnlskfrkvq heldeaeera diaesqvnkl
     1921 raksrdigak glnee
//
LOCUS       NP_001334510             381 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 8 [Mus musculus].
ACCESSION   NP_001334510
VERSION     NP_001334510.1
DBSOURCE    REFSEQ: accession NM_001347581.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 381)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 381)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 381)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 381)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 381)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 381)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 381)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 381)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 381)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 381)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            Transcript Variant: This variant (18) differs in the 5' UTR, lacks
            an in-frame exon in the central coding region, and uses an
            alternate splice site that results in a frameshift in the 3' coding
            region, compared to variant 3. The encoded isoform (8) has a
            distinct C-terminus and is shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.21211.1,
                                           SRR11927932.3655481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..381
                     /product="myocyte-specific enhancer factor 2C isoform 8"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=40923
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..381
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347581.2:401..1546"
                     /note="isoform 8 is encoded by transcript variant 18"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv nqrinnsqsa qslatpvvsv atptlpgqgm
      301 ggypsaistt ygteyslssa dlsslsgfnt asalhlgsvt gwqqqhlhnm ppsalsqlgp
      361 yhhpfeiptt hhaprggevs c
//
LOCUS       NP_001297074             286 aa            linear   ROD 27-AUG-2025
DEFINITION  paired box protein Pax-6 isoform 3 [Mus musculus].
ACCESSION   NP_001297074
VERSION     NP_001297074.1
DBSOURCE    REFSEQ: accession NM_001310145.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 286)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 286)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 286)
  AUTHORS   Georgala,P.A., Carr,C.B. and Price,D.J.
  TITLE     The role of Pax6 in forebrain development
  JOURNAL   Dev Neurobiol 71 (8), 690-709 (2011)
   PUBMED   21538923
  REMARK    Review article
REFERENCE   4  (residues 1 to 286)
  AUTHORS   Kim,J. and Lauderdale,J.D.
  TITLE     Analysis of Pax6 expression using a BAC transgene reveals the
            presence of a paired-less isoform of Pax6 in the eye and olfactory
            bulb
  JOURNAL   Dev Biol 292 (2), 486-505 (2006)
   PUBMED   16464444
  REMARK    GeneRIF: Pax6 expression, analyzed using a BAC transgene, revealed
            the presence of a paired-less isoform in the eye and olfactory
            bulb.
REFERENCE   5  (residues 1 to 286)
  AUTHORS   Xu,P.X., Zhang,X., Heaney,S., Yoon,A., Michelson,A.M. and Maas,R.L.
  TITLE     Regulation of Pax6 expression is conserved between mice and flies
  JOURNAL   Development 126 (2), 383-395 (1999)
   PUBMED   9847251
REFERENCE   6  (residues 1 to 286)
  AUTHORS   Ton,C.C., Miwa,H. and Saunders,G.F.
  TITLE     Small eye (Sey): cloning and characterization of the murine homolog
            of the human aniridia gene
  JOURNAL   Genomics 13 (2), 251-256 (1992)
   PUBMED   1612585
REFERENCE   7  (residues 1 to 286)
  AUTHORS   Hill,R.E., Favor,J., Hogan,B.L., Ton,C.C., Saunders,G.F.,
            Hanson,I.M., Prosser,J., Jordan,T., Hastie,N.D. and van
            Heyningen,V.
  TITLE     Mouse small eye results from mutations in a paired-like
            homeobox-containing gene
  JOURNAL   Nature 354 (6354), 522-525 (1991)
   PUBMED   1684639
  REMARK    Erratum:[Nature. 1992 Feb 20;355(6362):750. doi: 10.1038/355750a0.
            PMID: 1346927]
REFERENCE   8  (residues 1 to 286)
  AUTHORS   Walther,C. and Gruss,P.
  TITLE     Pax-6, a murine paired box gene, is expressed in the developing CNS
  JOURNAL   Development 113 (4), 1435-1449 (1991)
   PUBMED   1687460
REFERENCE   9  (residues 1 to 286)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (residues 1 to 286)
  AUTHORS   Theiler,K., Varnum,D.S. and Stevens,L.C.
  TITLE     Development of Dickie's small eye, a mutation in the house mouse
  JOURNAL   Anat Embryol (Berl) 155 (1), 81-86 (1978)
   PUBMED   103464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512589.4, CK617741.1,
            CX565124.1, CN539723.1 and AK139054.1.
            
            Summary: This gene encodes a homeobox-containing protein that
            functions as a regulator of transcription. It plays a key role in
            the development of neural tissues, particularly the eye. Activity
            of this protein is also required for expression of glucagon in the
            pancreas. This gene is regulated by multiple enhancers located up
            to tens or hundreds of kilobases upstream and downstream of the
            transcription start sites. Mutations in this gene or deletion of
            these regulatory elements results in severe defects in eye
            development. Alternative splicing and the use of alternative
            promoters results in multiple transcript variants, some of which
            encode proteins that lack the N-terminal paired domain. [provided
            by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (7) differs in the 5' UTR and
            lacks a portion of the 5' coding region compared to variant 1. It
            initiates from the P alpha promoter. The encoded isoform (3) has a
            shorter N-terminus and lacks the paired domain, compared to isoform
            1. Variants 7 and 8 encode the same protein (isoform 3, also known
            as DeltaPD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.281320.1,
                                           SRR9219382.99038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 55.31 cM"
     Protein         1..286
                     /product="paired box protein Pax-6 isoform 3"
                     /note="paired box protein Pax-6; oculorhombin; Dickie's
                     small eye; paired box gene 6"
                     /calculated_mol_wt=31638
     Region          76..131
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..286
                     /gene="Pax6"
                     /gene_synonym="1500038E17Rik; AEY11; Dey; Gsfaey11; Pax-6;
                     Sey"
                     /coded_by="NM_001310145.1:612..1472"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:18508"
                     /db_xref="MGI:MGI:97490"
ORIGIN      
        1 mgadgmydkl rmlngqtgsw gtrpgwypgt svpgqptqdg cqqqegggen tnsissnged
       61 sdeaqmrlql krklqrnrts ftqeqieale keferthypd vfarerlaak idlpeariqv
      121 wfsnrrakwr reeklrnqrr qasntpship isssfstsvy qpipqpttpv ssftsgsmlg
      181 rtdtaltnty salppmpsft mannlpmqpp vpsqtssysc mlptspsvng rsydtytpph
      241 mqthmnsqpm gtsgttstgl ispgvsvpvq vpgsepdmsq ywprlq
//
LOCUS       NP_001129533             442 aa            linear   ROD 27-AUG-2025
DEFINITION  endothelin receptor type B isoform 1 precursor [Mus musculus].
ACCESSION   NP_001129533
VERSION     NP_001129533.1
DBSOURCE    REFSEQ: accession NM_001136061.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Perry,C.H., Lavado,A., Thulabandu,V., Ramirez,C., Pare,J.,
            Dixit,R., Mishra,A., Yang,J., Yu,J. and Cao,X.
  TITLE     TEAD switches interacting partners along neural progenitor lineage
            progression to execute distinct functions
  JOURNAL   Genes Dev 39 (13-14), 849-867 (2025)
   PUBMED   40389325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Ramalingam,H., Alvarez,J., Flaten,A., Cobo-Stark,P., Foster,N.,
            Grilli,E., Lakhia,R., Aboudehen,K., Carroll,T. and Patel,V.
  TITLE     An RNA transmethylation pathway governs kidney nephrogenic
            potential
  JOURNAL   Nat Commun 16 (1), 4930 (2025)
   PUBMED   40436842
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 442)
  AUTHORS   McInnis,J.J., LeComte,M.D., Reed,L.F., Torsney,E.E., Del
            Rio-Guerra,R., Poynter,M.E. and Spees,J.L.
  TITLE     Microglial cell proliferation is regulated, in part, by reactive
            astrocyte ETBR signaling after ischemic stroke
  JOURNAL   Exp Neurol 385, 115125 (2025)
   PUBMED   39716588
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Tan,J., Duron,A., Sucov,H.M. and Makita,T.
  TITLE     Placode and neural crest origins of congenital deafness in mouse
            models of Waardenburg-Shah syndrome
  JOURNAL   iScience 28 (1), 111680 (2024)
   PUBMED   39868048
  REMARK    Erratum:[iScience. 2025 Apr 11;28(5):112400. doi:
            10.1016/j.isci.2025.112400. PMID: 40276772]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Osada,S., Mizuno,K., Saido,T.C., Suzuki,K., Kuroki,T. and Ohno,S.
  TITLE     A new member of the protein kinase C family, nPKC theta,
            predominantly expressed in skeletal muscle
  JOURNAL   Mol Cell Biol 12 (9), 3930-3938 (1992)
   PUBMED   1508194
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Russell,L.B., Hunsicker,P.R., Cacheiro,N.L. and Rinchik,E.M.
  TITLE     Genetic, cytogenetic, and molecular analyses of mutations induced
            by melphalan demonstrate high frequencies of heritable deletions
            and other rearrangements from exposure of postspermatogonial stages
            of the mouse
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 6182-6186 (1992)
   PUBMED   1352884
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Russell,L.B., Hunsicker,P.R. and Shelby,M.D.
  TITLE     Melphalan, a second chemical for which specific-locus mutation
            induction in the mouse is maximum in early spermatids
  JOURNAL   Mutat Res 282 (3), 151-158 (1992)
   PUBMED   1378547
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Mayer,T.C.
  TITLE     Enhancement of melanocyte development from piebald neural crest by
            a favorable tissue environment
  JOURNAL   Dev Biol 56 (2), 255-262 (1977)
   PUBMED   849800
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Womack,J.E., Davisson,M.T., Eicher,E.M. and Kendall,D.A.
  TITLE     Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10)
            on mouse chromosome 14
  JOURNAL   Biochem Genet 15 (3-4), 347-355 (1977)
   PUBMED   405970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154670.2 and AC110092.4.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor family. It encodes a receptor for endothelins, peptides
            that are involved in vasocontriction. The encoded protein activates
            a phosphatidylinositol-calcium second messenger system and is
            required for the development of enteric neurons and melanocytes.
            Gene disruption causes pigmentation anomalies, deafness, and
            abnormal dilation of the colon due to defects of neural
            crest-derived cells. Mutations in this gene are found in the
            piebald mouse, and mouse models of Hirschsprung's disease and
            Waardenburg syndrome type 4. Renal collecting duct-specific gene
            deletion causes sodium retention and hypertension. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083415.1, SRR7345562.1234189.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 53.05 cM"
     Protein         1..442
                     /product="endothelin receptor type B isoform 1 precursor"
                     /note="piebald; endothelin B receptor; endothelin receptor
                     non-selective type"
                     /calculated_mol_wt=46902
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2677
     mat_peptide     27..442
                     /product="Endothelin receptor type B. /id=PRO_0000012730"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
                     /calculated_mol_wt=46902
     Region          50..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Region          102..397
                     /region_name="7tmA_ET-BR"
                     /note="endothelin B receptor, member of the class A family
                     of seven-transmembrane G protein-coupled receptors;
                     cd15976"
                     /db_xref="CDD:320642"
     Site            102..126
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          103..129
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320642"
     Region          136..162
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320642"
     Site            138..163
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            order(158,161..162,174..179,181..182,185,230,232..236,270,
                     273..275,277..279,281..282,336,339..340,342..343,346,
                     364..365,367..369,372,375..376)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320642"
     Region          174..204
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320642"
     Site            176..197
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          216..236
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320642"
     Site            219..243
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          270..295
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320642"
     Site            272..296
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Region          316..346
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320642"
     Site            325..350
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            363..389
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          365..390
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320642"
     Site            419
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            439
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     CDS             1..442
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /coded_by="NM_001136061.3:264..1592"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS27317.1"
                     /db_xref="GeneID:13618"
                     /db_xref="MGI:MGI:102720"
ORIGIN      
        1 mqspasrcgr alvalllacg flgvwgekrg fppaqatlsl lgtkevmtpp tktswtrgsn
       61 sslmrssapa evtkggrgag vpprsfpppc qrnieisktf kyintivscl vfvlgiigns
      121 tllriiyknk cmrngpnili aslalgdllh iiidipinty kllaedwpfg aemcklvpfi
      181 qkasvgitvl slcalsidry ravaswsrik gigvpkwtav eivliwvvsv vlavpeaigf
      241 dmitsdykgk plrvcmlnpf qktafmqfyk takdwwlfsf yfclplaita vfytlmtcem
      301 lrkksgmqia lndhlkqrre vaktvfclvl vfalcwlplh lsrilkltly dqsnphrcel
      361 lsfllvldyi ginmaslnsc inpialylvs krfkncfksc lccwcqtfee kqsleekqsc
      421 lkfkandhgy dnfrssnkys ss
//
LOCUS       NP_001352007             587 aa            linear   ROD 27-AUG-2025
DEFINITION  APOBEC1 complementation factor isoform 2 [Mus musculus].
ACCESSION   NP_001352007 XP_006527394
VERSION     NP_001352007.1
DBSOURCE    REFSEQ: accession NM_001365078.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 587)
  AUTHORS   Qian,S., Zhang,C., Li,W., Song,S., Lin,G., Cheng,Z., Zhou,W.,
            Yin,H., Wang,Y., Li,H., Shen,Y.H. and Sun,Z.
  TITLE     Enzyme-independent functions of HDAC3 in the adult heart
  JOURNAL   Acta Pharm Sin B 15 (7), 3561-3574 (2025)
   PUBMED   40698142
REFERENCE   2  (residues 1 to 587)
  AUTHORS   Ruan,W., Li,T., Bang,I.H., Lee,J., Deng,W., Ma,X., Luo,C., Du,F.,
            Yoo,S.H., Kim,B., Li,J., Yuan,X., Figarella,K., An,Y.A., Wang,Y.Y.,
            Liang,Y., DeBerge,M., Zhang,D., Zhou,Z., Wang,Y., Gorham,J.M.,
            Seidman,J.G., Seidman,C.E., Aranki,S.F., Nair,R., Li,L., Narula,J.,
            Zhao,Z., Gorfe,A.A., Muehlschlegel,J.D., Tsai,K.L. and
            Eltzschig,H.K.
  TITLE     BMAL1-HIF2A heterodimer modulates circadian variations of
            myocardial injury
  JOURNAL   Nature 641 (8064), 1017-1028 (2025)
   PUBMED   40269168
REFERENCE   3  (residues 1 to 587)
  AUTHORS   Fuchs,M.A.A., Burke,E.J., Latic,N., Murray,S.L., Li,H.,
            Sparks,M.A., Abraham,D., Zhang,H., Rosenberg,P., Saleem,U.,
            Hansen,A., Miller,S.E., Ferreira,D., Hanzelmann,S., Hausmann,F.,
            Huber,T., Erben,R.G., Fisher-Wellman,K., Bursac,N., Wolf,M. and
            Grabner,A.
  TITLE     Fibroblast growth factor 23 and fibroblast growth factor receptor 4
            promote cardiac metabolic remodeling in chronic kidney disease
  JOURNAL   Kidney Int 107 (5), 852-868 (2025)
   PUBMED   39923962
REFERENCE   4  (residues 1 to 587)
  AUTHORS   Perelli,R.M., Dewars,E.R., Cope,H., Behura,A.S., Ponek,A.Q.,
            Sala,A.M., Zhang,Z., Muralidharan,P., Moya-Mendez,M.E., Berkman,A.,
            Monaco,G.G., Sullivan,M.C., Ezekian,J.E., Yang,Q., Sun,B.,
            Kurzlechner,L.M., Asokan,T., Breglio,A.M., Campbell,M.J.,
            Spector,Z.Z., Rehder,C.W., Tang,P.C., James,C.A., Calkins,H.,
            Shashi,V. and Landstrom,A.P.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic
            Cardiomyopathy
  JOURNAL   Circ Res 136 (7), 667-684 (2025)
   PUBMED   39963794
REFERENCE   5  (residues 1 to 587)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   6  (residues 1 to 587)
  AUTHORS   Dur,S., Krause,K., Pluntke,N. and Greeve,J.
  TITLE     Gene structure and expression of the mouse APOBEC-1 complementation
            factor: multiple transcriptional initiation sites and a spliced
            variant with a premature stop translation codon
  JOURNAL   Biochim Biophys Acta 1680 (1), 11-23 (2004)
   PUBMED   15451168
REFERENCE   7  (residues 1 to 587)
  AUTHORS   Wedekind,J.E., Dance,G.S., Sowden,M.P. and Smith,H.C.
  TITLE     Messenger RNA editing in mammals: new members of the APOBEC family
            seeking roles in the family business
  JOURNAL   Trends Genet 19 (4), 207-216 (2003)
   PUBMED   12683974
  REMARK    Review article
            Erratum:[Trends Genet. 2003 Jul;19(7):369]
REFERENCE   8  (residues 1 to 587)
  AUTHORS   Petrich,B.G., Molkentin,J.D. and Wang,Y.
  TITLE     Temporal activation of c-Jun N-terminal kinase in adult transgenic
            heart via cre-loxP-mediated DNA recombination
  JOURNAL   FASEB J 17 (6), 749-751 (2003)
   PUBMED   12594183
REFERENCE   9  (residues 1 to 587)
  AUTHORS   Sohal,D.S., Nghiem,M., Crackower,M.A., Witt,S.A., Kimball,T.R.,
            Tymitz,K.M., Penninger,J.M. and Molkentin,J.D.
  TITLE     Temporally regulated and tissue-specific gene manipulations in the
            adult and embryonic heart using a tamoxifen-inducible Cre protein
  JOURNAL   Circ Res 89 (1), 20-25 (2001)
   PUBMED   11440973
REFERENCE   10 (residues 1 to 587)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125019.6 and AC117816.11.
            
            On Jul 25, 2018 this sequence version replaced XP_006527394.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19"
     Protein         1..587
                     /product="APOBEC1 complementation factor isoform 2"
                     /note="APOBEC-1 stimulating protein"
                     /calculated_mol_wt=64605
     Region          2..587
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     CDS             1..587
                     /gene="A1cf"
                     /gene_synonym="1810073H04Rik; 9130016M20Rik; Acf; ACF64;
                     ACF65; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; ASP;
                     MCM; mer; MerCreMer; Tg(Myh6-cre/Esr1*)1Jmk"
                     /coded_by="NM_001365078.1:93..1856"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS89374.1"
                     /db_xref="GeneID:69865"
                     /db_xref="MGI:MGI:1917115"
ORIGIN      
        1 mesnhksgdg lsgtqkeaal ralvqrtgys lvqengqrky ggpppgwdst ppergceifi
       61 gklprdlfed eliplcekig kiyemrlmmd fngnnrgyaf vtfsnkqeak naikqlnnye
      121 irtgrllgvc asvdncrlfv ggipktkkre eilsemkkvt egvvdvivyp saadktknrg
      181 fafveyeshr aaamarrrll pgriqlwghp iavdwaepev evdedtmssv kilyvrnlml
      241 stseemieke fnsikpgave rvkkirdyaf vhfsnredav eamkalngkv ldgspievtl
      301 akpvdkdsyv rytrgtggrn tmlqgeytyp lshvydpttt ylgapvfytp qayaaipslh
      361 fpatkghlsn ralirtpsvr gaagvrglgg rgylaytglg rgyhvkgdkr edklydllpg
      421 meltpmntvs lkpqgiklap qileeicqkn nwgqpvyqlh saigqdqrql flykvtipal
      481 asqnpaihpf ippklsayvd eakryaaeht lqtlgipteg gdagttapta tsatvfpgya
      541 vpsatapvst aqlkqavtlg qdlaayttye vyptfalttr gdaygtf
//
LOCUS       NP_001398587             879 aa            linear   ROD 27-AUG-2025
DEFINITION  autotaxin isoform 12 [Mus musculus].
ACCESSION   NP_001398587 XP_006520657
VERSION     NP_001398587.1
DBSOURCE    REFSEQ: accession NM_001411658.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 879)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 879)
  AUTHORS   Dacheux,M.A., Norman,D.D., Shin,Y., Tigyi,G.J. and Lee,S.C.
  TITLE     Deleting autotaxin in LysM+ myeloid cells impairs innate tumor
            immunity in models of metastatic melanoma
  JOURNAL   iScience 27 (10), 110971 (2024)
   PUBMED   39398245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 879)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   4  (residues 1 to 879)
  AUTHORS   Petersen-Cherubini,C.L., Liu,Y., Deffenbaugh,J.L., Murphy,S.P.,
            Xin,M., Rau,C.N., Yang,Y. and Lovett-Racke,A.E.
  TITLE     Dysregulated autotaxin expression by T cells in multiple sclerosis
  JOURNAL   J Neuroimmunol 387, 578282 (2024)
   PUBMED   38183947
  REMARK    GeneRIF: Dysregulated autotaxin expression by T cells in multiple
            sclerosis.
REFERENCE   5  (residues 1 to 879)
  AUTHORS   Giganti,A., Rodriguez,M., Fould,B., Moulharat,N., Coge,F.,
            Chomarat,P., Galizzi,J.P., Valet,P., Saulnier-Blache,J.S.,
            Boutin,J.A. and Ferry,G.
  TITLE     Murine and human autotaxin alpha, beta, and gamma isoforms: gene
            organization, tissue distribution, and biochemical characterization
  JOURNAL   J Biol Chem 283 (12), 7776-7789 (2008)
   PUBMED   18175805
  REMARK    GeneRIF: Murine and human autotaxin alpha, beta, and gamma
            isoforms: gene organization, tissue distribution, and biochemical
            characterization.
REFERENCE   6  (residues 1 to 879)
  AUTHORS   Koike,S., Keino-Masu,K., Ohto,T. and Masu,M.
  TITLE     The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions
            as a signal peptide
  JOURNAL   Genes Cells 11 (2), 133-142 (2006)
   PUBMED   16436050
REFERENCE   7  (residues 1 to 879)
  AUTHORS   Jansen,S., Stefan,C., Creemers,J.W., Waelkens,E., Van Eynde,A.,
            Stalmans,W. and Bollen,M.
  TITLE     Proteolytic maturation and activation of autotaxin (NPP2), a
            secreted metastasis-enhancing lysophospholipase D
  JOURNAL   J Cell Sci 118 (Pt 14), 3081-3089 (2005)
   PUBMED   15985467
REFERENCE   8  (residues 1 to 879)
  AUTHORS   Bachner,D., Ahrens,M., Betat,N., Schroder,D. and Gross,G.
  TITLE     Developmental expression analysis of murine autotaxin (ATX)
  JOURNAL   Mech Dev 84 (1-2), 121-125 (1999)
   PUBMED   10473125
REFERENCE   9  (residues 1 to 879)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (residues 1 to 879)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123644.8.
            
            On Aug 30, 2022 this sequence version replaced XP_006520657.1.
            
            Summary: This gene encodes a member of the phosphodiesterase and
            nucleotide pyrophosphatase family of bifunctional enzymes that
            hydrolize phosphodiester bonds of various nucleotides. The encoded
            protein undergoes proteolytic processing to generate a mature
            protein with lysophospholipase D activity, catalyzing the cleavage
            of the choline group from lysophosphatidylcholine to produce
            lysophosphatidic acid. This gene is expressed in numerous tissues
            and participates in neural development, obesity, inflammation and
            oncogenesis. A complete lack of the encoded protein in mice results
            in aberrant vascular and neuronal development leading to embryonic
            lethality. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (12) uses an alternate exon 1,
            lacks an in-frame exon, uses an alternate in-frame splice site, and
            contains an alternate in-frame exon in the central coding region,
            compared to variant 1. The encoded isoform (12) has a distinct
            N-terminus and is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.28684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.6 cM"
     Protein         1..879
                     /product="autotaxin isoform 12"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; autotaxin; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2"
                     /calculated_mol_wt=100661
     Region          52..93
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          94..137
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          161..473
                     /region_name="Phosphodiest"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; pfam01663"
                     /db_xref="CDD:396300"
     Site            order(167,204..205,226,307,311,354..355,470)
                     /site_type="active"
                     /db_xref="CDD:293742"
     Site            order(167,204..205,226,307,311,355,470)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293742"
     Site            495..497
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:293742"
     Region          631..861
                     /region_name="NUC"
                     /note="DNA/RNA non-specific endonuclease; smart00477"
                     /db_xref="CDD:214683"
     Site            order(693..694,696,733,737)
                     /site_type="active"
                     /db_xref="CDD:238043"
     Site            order(693..694,737)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238043"
     CDS             1..879
                     /gene="Enpp2"
                     /gene_synonym="ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha;
                     Pdnp2"
                     /coded_by="NM_001411658.1:107..2746"
                     /note="isoform 12 is encoded by transcript variant 12"
                     /db_xref="GeneID:18606"
                     /db_xref="MGI:MGI:1321390"
ORIGIN      
        1 msrhadpvis lftfaigvnl clgftasrik raewdegppt vlsdspwtnt sgsckgrcfe
       61 lqevgppdcr cdnlcksyss cchdfdelcl ktargwectk drcgevrnee nachcsedcl
      121 srgdcctnyq vvckgeshwv dddceeirvp ecpagfvrpp liifsvdgfr asymkkgskv
      181 mpnieklrsc gthapymrpv yptktfpnly tlatglypes hgivgnsmyd pvfdatfhlr
      241 grekfnhrww ggqplwitat kqgvragtff wsvsipherr iltilqwlsl pdnerpsvya
      301 fyseqpdfsg hkygpfgpem tnplreidkt vgqlmdglkq lklhrcvnvi fvgdhgmedv
      361 tcdrteflsn yltnvdditl vpgtlgrirp kipnnlkydp kaiianltck kpdqhfkpym
      421 kqhlpkrlhy annrriedlh llverrwhva rkpldvykkp sgkcffqgdh gfdnkvnsmq
      481 tvfvgygptf kyrtkvppfe nielynvmcd llglkpapnn gthgslnhll rtntfrptlp
      541 eevsrpnypg imylqsdfdl gctcddknkl eelnkrlhtk gsteaetgkf rgskhenkks
      601 lngnveprke rhllygrpav lyrtsydily htdfesgyse iflmplwtsy tiskqaevss
      661 ipehltncvr pdvrvspgfs qnclaykndk qmsygflfpp ylssspeaky daflvtnmvp
      721 mypafkrvwt yfqrvlvkky aserngvnvi sgpifdynyn glrdiedeik qyvegssipv
      781 pthyysiits cldftqpadk cdgplsvssf ilphrpdnde scnssedesk wveelmkmht
      841 arvrdiehlt gldfyrktsr syseiltlkt ylhtyesei
//
LOCUS       NP_001156871             371 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform d [Mus musculus].
ACCESSION   NP_001156871
VERSION     NP_001156871.1
DBSOURCE    REFSEQ: accession NM_001163399.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 371)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014133.1, ERR3363658.4743793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..371
                     /product="ELAV-like protein 4 isoform d"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40847
     Region          48..370
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..371
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001163399.2:368..1483"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS51261.1"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mewnglkmii stmepqvsng ptsntsngps snnrncpspm qtgaatddsk tnlivnylpq
       61 nmtqeefrsl fgsigeiesc klvrdkitgq slgygfvnyi dpkdaekain tlnglrlqtk
      121 tikvsyarps sasirdanly vsglpktmtq keleqlfsqy griitsrilv dqvtgvsrgv
      181 gfirfdkrie aeeaikglng qkpsgatepi tvkfannpsq kssqallsql yqspnrrypg
      241 plhhqaqrfr ldnllnmayg vkrfspitid gmtslvgmni pghtgtgwci fvynlspdsd
      301 esvlwqlfgp fgavnnvkvi rdfntnkckg fgfvtmtnyd eaamaiasln gyrlgdrvlq
      361 vsfktnkahk s
//
LOCUS       NP_001409070             824 aa            linear   ROD 27-AUG-2025
DEFINITION  hypoxia-inducible factor 1-alpha isoform 4 [Mus musculus].
ACCESSION   NP_001409070 XP_036013089
VERSION     NP_001409070.1
DBSOURCE    REFSEQ: accession NM_001422141.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 824)
  AUTHORS   Sanchez-Garcia,M.A., Lara-Urena,N., March-Diaz,R., Ortega-de San
            Luis,C., Quinones-Canete,S., Mora-Romero,B., Barba-Reyes,J.M.,
            Cabello-Rivera,D., Romero-Molina,C., Heras-Garvin,A., Navarro,V.,
            Lopez-Barneo,J., Vizuete,M., Vitorica,J., Munoz-Cabello,A.M.,
            Munoz-Manchado,A.B., Cokman,M.E., Rosales-Nieves,A.E. and
            Pascual,A.
  TITLE     Inactivation of the PHD3-FOXO3 axis blunts the type I interferon
            response in microglia and ameliorates Alzheimer's disease
            progression
  JOURNAL   Sci Adv 11 (22), eadu2244 (2025)
   PUBMED   40435260
REFERENCE   2  (residues 1 to 824)
  AUTHORS   Pekayvaz,K., Kilani,B., Joppich,M., Eivers,L., Brambs,S.,
            Knottenberg,V., Akgol,S., Yue,K., Li,L., Martinez-Navarro,A.,
            Kaiser,R., Meissner,N., Schulz,H., Belz,L., Akhalkatsi,A.,
            Stockhausen,S., Mueller,T.T., Millonig,S., Hartelt,L., Gold,C.,
            Janjic,A., Polewka,V., Wendler,F., Droste Zu Senden,A., Titova,A.,
            Leunig,A., Voelkl,M., Engelmann,B., Hernandez Petzsche,M.R.,
            Boeckh-Behrens,T., Liebig,T., Winning,S., Fandrey,J., Dichgans,M.,
            Enard,W., Zimmer,R., Tiedt,S., Massberg,S., Nicolai,L. and Stark,K.
  TITLE     Immunothrombolytic monocyte-neutrophil axes dominate the
            single-cell landscape of human thrombosis and correlate with
            thrombus resolution
  JOURNAL   Immunity 58 (5), 1343-1358 (2025)
   PUBMED   40280129
REFERENCE   3  (residues 1 to 824)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 824)
  AUTHORS   Ruan,W., Li,T., Bang,I.H., Lee,J., Deng,W., Ma,X., Luo,C., Du,F.,
            Yoo,S.H., Kim,B., Li,J., Yuan,X., Figarella,K., An,Y.A., Wang,Y.Y.,
            Liang,Y., DeBerge,M., Zhang,D., Zhou,Z., Wang,Y., Gorham,J.M.,
            Seidman,J.G., Seidman,C.E., Aranki,S.F., Nair,R., Li,L., Narula,J.,
            Zhao,Z., Gorfe,A.A., Muehlschlegel,J.D., Tsai,K.L. and
            Eltzschig,H.K.
  TITLE     BMAL1-HIF2A heterodimer modulates circadian variations of
            myocardial injury
  JOURNAL   Nature 641 (8064), 1017-1028 (2025)
   PUBMED   40269168
REFERENCE   5  (residues 1 to 824)
  AUTHORS   Guo,C., Niu,Y., Pan,X., Sharma,D., Lau,E., Jin,Y., Luxardi,G.,
            Amanullah,M., Lo,K., Moshiri,A., Qian,J., Montaner,S. and Sodhi,A.
  TITLE     Hypoglycemia promotes inner blood-retinal barrier breakdown and
            retinal vascular leakage in diabetic mice
  JOURNAL   Sci Transl Med 17 (796), eadq5355 (2025)
   PUBMED   40305573
REFERENCE   6  (residues 1 to 824)
  AUTHORS   Li,H., Ko,H.P. and Whitlock,J.P.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 824)
  AUTHORS   Wood,S.M., Gleadle,J.M., Pugh,C.W., Hankinson,O. and Ratcliffe,P.J.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 824)
  AUTHORS   Semenza,G.L., Rue,E.A., Iyer,N.V., Pang,M.G. and Kearns,W.G.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 824)
  AUTHORS   Wenger,R.H., Rolfs,A., Marti,H.H., Guenet,J.L. and Gassmann,M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 824)
  AUTHORS   Obara,N. and Takeda,M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Jun 6, 2023 this sequence version replaced XP_036013089.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.253033.1,
                                           SRR17253014.4874676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..824
                     /product="hypoxia-inducible factor 1-alpha isoform 4"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=92126
     Region          1..71
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(6..7,9..11,14..15,17..18,43..44)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Site            order(20..21,23..24,27..28,31..32,43..45,48..49,52,55..56,
                     59)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          81..136
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          242..327
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(243,247,253,266..269,295,300)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(263,267,275,278..279,307,309)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          552..581
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:463274"
     Region          787..823
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     CDS             1..824
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001422141.1:89..2563"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 msserrkeks rdaarsrrsk esevfyelah qlplphnvss hldkasvmrl tisylrvrkl
       61 ldaggldsed emkaqmdcfy lkaldgfvmv ltddgdmvyi sdnvnkymgl tqfeltghsv
      121 fdfthpcdhe emremlthrn gpvrkgkeln tqrsfflrmk ctltsrgrtm niksatwkvl
      181 hctghihvyd tnsnqpqcgy kkppmtclvl icepiphpsn ieipldsktf lsrhsldmkf
      241 sycderitel mgyepeellg rsiyeyyhal dsdhltkthh dmftkgqvtt gqyrmlakrg
      301 gyvwvetqat viyntknsqp qcivcvnyvv sgiiqhdlif slqqtesvlk pvessdmkmt
      361 qlftkvesed tsclfdklkk epdaltllap aagdtiisld fgsddteted qqledvplyn
      421 dvmfpssnek lninlamspl pssetpkplr ssadpalnqe valklesspe slglsftmpq
      481 iqdqpaspsd gstrqssper llqenvntpn fsqpnspsey cfdvdsdmvn vfklelvekl
      541 faedteaknp fstqdtdldl emlapyipmd ddfqlrsfdq lsplesnsps ppsmstvtgf
      601 qqtqlqkpti tatatttatt desktetkdn kedikilias psstqvpqet ttakasaysg
      661 thsrtaspdr agkrvieqtd kahprslnls atlnqrntvp eeelnpktia sqnaqrkrkm
      721 ehdgslfqaa gigtllqqpg dcaptmslsw krvkgfisse qngteqktii lipsdlacrl
      781 lgqsmdesgl pqltsydcev napiqgsrnl lqgeellral dqvn
//
LOCUS       NP_001396724             801 aa            linear   ROD 27-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 22 isoform 2 [Mus
            musculus].
ACCESSION   NP_001396724
VERSION     NP_001396724.1
DBSOURCE    REFSEQ: accession NM_001409795.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 801)
  AUTHORS   Acero-Bedoya,S., Higgs,E.F., Martinez,A.C., Tonea,R. and
            Gajewski,T.F.
  TITLE     Dendritic cell-intrinsic PTPN22 negatively regulates antitumor
            immunity and impacts anti-PD-L1 efficacy
  JOURNAL   J Immunother Cancer 12 (10), e009588 (2024)
   PUBMED   39461876
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 801)
  AUTHORS   Cai,H., Chen,S., Jiang,Z., Chen,L. and Yang,X.
  TITLE     PTPN22 through the regulation of Th17/Treg balance acts as a
            potential target for the treatment of Graves' disease
  JOURNAL   Tissue Cell 90, 102502 (2024)
   PUBMED   39083881
  REMARK    GeneRIF: PTPN22 through the regulation of Th17/Treg balance acts as
            a potential target for the treatment of Graves' disease.
REFERENCE   3  (residues 1 to 801)
  AUTHORS   Lee,J., Yurkovetskiy,L.A., Reiman,D., Frommer,L., Strong,Z.,
            Chang,A., Kahaly,G.J., Khan,A.A. and Chervonsky,A.V.
  TITLE     Androgens contribute to sex bias of autoimmunity in mice by T
            cell-intrinsic regulation of Ptpn22 phosphatase expression
  JOURNAL   Nat Commun 15 (1), 7688 (2024)
   PUBMED   39227386
  REMARK    GeneRIF: Androgens contribute to sex bias of autoimmunity in mice
            by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 801)
  AUTHORS   Orozco,R.C., Marquardt,K., Pratumchai,I., Shaikh,A.F., Mowen,K.,
            Domissy,A., Teijaro,J.R. and Sherman,L.A.
  TITLE     Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22
            enhances anti-viral immunity
  JOURNAL   PLoS Pathog 20 (3), e1012095 (2024)
   PUBMED   38512979
  REMARK    GeneRIF: Autoimmunity-associated allele of tyrosine phosphatase
            gene PTPN22 enhances anti-viral immunity.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 801)
  AUTHORS   Li,S., Luo,Z., Su,S., Wen,L., Xian,G., Zhao,J., Xu,X., Xu,D. and
            Zeng,Q.
  TITLE     Targeted inhibition of PTPN22 is a novel approach to alleviate
            osteogenic responses in aortic valve interstitial cells and aortic
            valve lesions in mice
  JOURNAL   BMC Med 21 (1), 252 (2023)
   PUBMED   37443055
  REMARK    GeneRIF: Targeted inhibition of PTPN22 is a novel approach to
            alleviate osteogenic responses in aortic valve interstitial cells
            and aortic valve lesions in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 801)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (residues 1 to 801)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (residues 1 to 801)
  AUTHORS   Gregorieff,A., Cloutier,J.F. and Veillette,A.
  TITLE     Sequence requirements for association of protein-tyrosine
            phosphatase PEP with the Src homology 3 domain of inhibitory
            tyrosine protein kinase p50(csk)
  JOURNAL   J Biol Chem 273 (21), 13217-13222 (1998)
   PUBMED   9582365
REFERENCE   9  (residues 1 to 801)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   10 (residues 1 to 801)
  AUTHORS   Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L.
  TITLE     Characterization of hematopoietic intracellular protein tyrosine
            phosphatases: description of a phosphatase containing an SH2 domain
            and another enriched in proline-, glutamic acid-, serine-, and
            threonine-rich sequences
  JOURNAL   Mol Cell Biol 12 (5), 2396-2405 (1992)
   PUBMED   1373816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124698.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861859.5863545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     Protein         1..801
                     /product="tyrosine-protein phosphatase non-receptor type
                     22 isoform 2"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, non-receptor type 8;
                     PEST domain-enriched tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 22;
                     hematopoietic cell protein-tyrosine phosphatase 70Z-PEP"
                     /calculated_mol_wt=89527
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCD.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2R2; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          57..290
                     /region_name="PTPc-N22"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 22; cd14602"
                     /db_xref="CDD:350450"
     Region          330..358
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          536..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          597..619
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          613..621
                     /region_name="Interaction with CSK.
                     /evidence=ECO:0000269|PubMed:8890164"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          652..694
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            679
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Site            686
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          712..801
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     CDS             1..801
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /coded_by="NM_001409795.1:125..2530"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
ORIGIN      
        1 mdqreilqql lkeaqkkkln seefaseflk lkrqstkyka dkiypttvaq rpknikknry
       61 kdilpydhsl velslltsde dssyinasfi kgvygpkayi atqgplsttl ldfwrmiwey
      121 rilvivmacm efemgkkkce rywaepgetq lqfgpfsisc eaekkksdyk irtlkakfnn
      181 etriiyqfhy knwpdhdvps sidpilqliw dmrcyqeddc vpicihcsag cgrtgvicav
      241 dytwmllkdg iipknfsvfn liqemrtqrp slvqtqeqye lvysavlelf krhmdvisdn
      301 hlgreiqaqc sipeqsltve adscpldlpk namrdvkttn qhskqgaeae stggsslglr
      361 tstmnaeeel vlhsakssps fnclelncgc nnkavitrng qaraspvvge plqkyqsldf
      421 gsmlfgscps alpintadry hnskgpvkrt kstpfeliqq rktndlavgd gfsclesqlh
      481 ehyslrelqv qrvahvssee lnyslpgacd ascvprhspg alrvhlytsl aedpyfsssp
      541 pnsadskmsf dlpekqdgat spgallpass ttsffysnph dslvmntlts fspplnqeta
      601 veapsrrtdd eippplpert pesfivveea epsprvtesl plvvtfgasp ecsgtsemks
      661 hdsvgftpsk nvklrspksd rhqdgspppp lpertlesff ladedciqaq avqtsstsyp
      721 ettenstssk qtlrtpgksf trskslkifr nmkksvcnss spskptervq pknsssflnf
      781 gfgnrfskpk gprnppsawn m
//
LOCUS       NP_062297                704 aa            linear   ROD 27-AUG-2025
DEFINITION  BLOC-3 complex member HPS1 isoform 1 [Mus musculus].
ACCESSION   NP_062297
VERSION     NP_062297.1
DBSOURCE    REFSEQ: accession NM_019424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 704)
  AUTHORS   Wang,J.Y., Michki,S.N., Sitaraman,S., Banaschewski,B.J., Jamal,R.,
            Gokey,J.J., Lin,S.M., Katzen,J.B., Basil,M.C., Cantu,E.,
            Kropski,J.A., Zepp,J.A., Frank,D.B. and Young,L.R.
  TITLE     Dysregulated alveolar epithelial cell progenitor function and
            identity in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 10 (3), e183483 (2024)
   PUBMED   39699958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 704)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 704)
  AUTHORS   Yuan,Y., Liu,T., Huang,X., Chen,Y., Zhang,W., Li,T., Yang,L.,
            Chen,Q., Wang,Y., Wei,A. and Li,W.
  TITLE     A zinc transporter, transmembrane protein 163, is critical for the
            biogenesis of platelet dense granules
  JOURNAL   Blood 137 (13), 1804-1817 (2021)
   PUBMED   33513603
REFERENCE   4  (residues 1 to 704)
  AUTHORS   Yu,J., He,X., Wei,A., Liu,T., Zhang,Q., Pan,Y., Hao,Z., Yang,L.,
            Yuan,Y., Zhang,Z., Zhang,C., Hao,C., Liu,Z. and Li,W.
  TITLE     HPS1 Regulates the Maturation of Large Dense Core Vesicles and
            Lysozyme Secretion in Paneth Cells
  JOURNAL   Front Immunol 11, 560110 (2020)
   PUBMED   33224134
  REMARK    GeneRIF: HPS1 Regulates the Maturation of Large Dense Core Vesicles
            and Lysozyme Secretion in Paneth Cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 704)
  AUTHORS   Summer,R., Krishna,R., Schriner,D., Cuevas-Mora,K., Sales,D.,
            Para,R., Roman,J., Nieweld,C., Gochuico,B.R. and Romero,F.
  TITLE     Matrix metalloproteinase activity in the lung is increased in
            Hermansky-Pudlak syndrome
  JOURNAL   Orphanet J Rare Dis 14 (1), 162 (2019)
   PUBMED   31272455
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 704)
  AUTHORS   Paigen,B., Holmes,P.A., Novak,E.K. and Swank,R.T.
  TITLE     Analysis of atherosclerosis susceptibility in mice with genetic
            defects in platelet function
  JOURNAL   Arteriosclerosis 10 (4), 648-652 (1990)
   PUBMED   2369371
REFERENCE   7  (residues 1 to 704)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   8  (residues 1 to 704)
  AUTHORS   McGarry,M.P., Novak,E.K. and Swank,R.T.
  TITLE     Progenitor cell defect correctable by bone marrow transplantation
            in five independent mouse models of platelet storage pool
            deficiency
  JOURNAL   Exp Hematol 14 (4), 261-265 (1986)
   PUBMED   3516713
REFERENCE   9  (residues 1 to 704)
  AUTHORS   Novak,E.K. and Swank,R.T.
  TITLE     Lysosomal dysfunctions associated with mutations at mouse pigment
            genes
  JOURNAL   Genetics 92 (1), 189-204 (1979)
   PUBMED   115747
REFERENCE   10 (residues 1 to 704)
  AUTHORS   LaVail,J.H., Nixon,R.A. and Sidman,R.L.
  TITLE     Genetic control of retinal ganglion cell projections
  JOURNAL   J Comp Neurol 182 (3), 399-421 (1978)
   PUBMED   102659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125458.3, BB843487.1, BG062886.2, U97149.1 and BC058332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171225.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.56 cM"
     Protein         1..704
                     /product="BLOC-3 complex member HPS1 isoform 1"
                     /note="Hermansky-Pudlak syndrome protein homolog;
                     hermansky-Pudlak syndrome 1 protein homolog; pale ear;
                     Hermansky-Pudlak syndrome 1 homolog; BLOC-3 complex member
                     HPS1"
                     /calculated_mol_wt=79741
     Region          2..159
                     /region_name="Fuz_longin_1"
                     /note="First Longin domain of FUZ, MON1 and HPS1;
                     pfam19036"
                     /db_xref="CDD:465953"
     Region          45..51
                     /region_name="[DE]-X(4)-L-L 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O08983.2)"
     Region          204..>249
                     /region_name="Fuz_longin_2"
                     /note="Second Longin domain of FUZ, MON1 and HPS1;
                     pfam19037"
                     /db_xref="CDD:465954"
     Region          246..350
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08983.2)"
     Region          520..526
                     /region_name="[DE]-X(4)-L-L 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O08983.2)"
     Region          544..699
                     /region_name="Fuz_longin_3"
                     /note="Third Longin domain of FUZ, MON1 and HPS1;
                     pfam19038"
                     /db_xref="CDD:465955"
     Region          648..654
                     /region_name="[DE]-X(4)-L-L 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O08983.2)"
     CDS             1..704
                     /gene="Hps1"
                     /gene_synonym="6030422N11Rik; ep; Gm21361; Hps"
                     /coded_by="NM_019424.3:204..2318"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS37992.1"
                     /db_xref="GeneID:192236"
                     /db_xref="MGI:MGI:2177763"
ORIGIN      
        1 mkcvlvateg aevlfywtde efaeslrlkl qqsedeeeel pvledqlstl lapviissmt
       61 mmeklsdtyt cfstendnhl yvlhlfgeyl fvaingdhse segdlrrklc vlkylfevhf
      121 glvtvdgqli rkelrppdle erarvwkhfq rllgtysylr dreqsfavea verlihpqlc
      181 eqsietlerh vvqainaspe rggeevlhaf llvhckllaf ysghgastlr padllalill
      241 vqdlqpspgt teeeeeeeds dspqrrpkss qnipvqqars qstsvptrss retdtdsisl
      301 peeyftpaps pgdqssgslv wldggtppsd alqmaedtpe glashspelp sprrifldan
      361 ikenycplvp htmyclplwp ginmvlltks pstplalily qlldgfslle kklkegqeag
      421 salrsqpfva dlrqkmdkfi knrvgqeiqn twlefkskaf srsepgsswe llqvcgklkr
      481 qlcviyrlsf lvtapsrggp hlpqhlqdra qklmkerlld wkdfllvksr rnvtmvsyle
      541 dfpglvhfiy vdrttgqmva pslspnekms selgkgplaa fvkakvwalv rlarrylqkg
      601 cttllfqegd frcsyflwfe ndmgyklqmi evpvlsddsv pigvlggdyy rkllryysks
      661 hpsepvrcye lltlhlsvip tdllvqqasq larrlgeasr vtlp
//
LOCUS       NP_001351472             673 aa            linear   ROD 27-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 16 [Mus musculus].
ACCESSION   NP_001351472 XP_006510321
VERSION     NP_001351472.1
DBSOURCE    REFSEQ: accession NM_001364543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Zhang,Z., Yu,Z., Chong,Y., Liu,Y., Liu,J., Ren,W., Xu,S. and
            Yang,G.
  TITLE     Evolution of cetacean-specific conserved non-coding elements
            suggests their role in the limb changes during secondary aquatic
            adaptation
  JOURNAL   BMC Biol 23 (1), 216 (2025)
   PUBMED   40670992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Yi,C., Kitamura,Y., Maezawa,S., Namekawa,S.H. and Cairns,B.R.
  TITLE     ZBTB16/PLZF regulates juvenile spermatogonial stem cell development
            through an extensive transcription factor poising network
  JOURNAL   Nat Struct Mol Biol 32 (7), 1213-1226 (2025)
   PUBMED   40033150
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Yue,W.Y., Zhang,Y., Jiang,T.X. and Qiu,X.B.
  TITLE     Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors
            Rpn10 and Rpn13 in Germ Cell Formation and Fertility
  JOURNAL   Cells 14 (10), 696 (2025)
   PUBMED   40422199
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 673)
  AUTHORS   Abe,S., Kagao,M., Asahi,T., Kato,R., Tani-Ichi,S., Shimba,A.,
            Ishibashi,R., Miyachi,H., Kitano,S., Miyazaki,M., Rodewald,H.R.,
            Toyoshima,F. and Ikuta,K.
  TITLE     The transcription factor RORalpha is required for the development
            of type 1 innate lymphoid cells in adult bone marrow
  JOURNAL   J Immunol 214 (4), 575-581 (2025)
   PUBMED   40079843
REFERENCE   5  (residues 1 to 673)
  AUTHORS   Zhang,M., Tao,S.C., Li,N., Feng,J., Shi,T., Yu,Y., Ren,X., Sha,J.,
            Mei,Z. and Jie,Z.
  TITLE     PLZF-expressing CD4+ T cells promote tissue-resident memory T cells
            in breaking immune tolerance in allergic asthma via
            IL-15/IL-15Ralpha signaling
  JOURNAL   Cell Commun Signal 23 (1), 138 (2025)
   PUBMED   40089783
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 673)
  AUTHORS   Johnson,D.R. and Hunt,D.M.
  TITLE     Hop-sterile, a mutant gene affecting sperm tail development in the
            mouse
  JOURNAL   J Embryol Exp Morphol 25 (2), 223-236 (1971)
   PUBMED   5088020
REFERENCE   7  (residues 1 to 673)
  AUTHORS   Hutton,J.J. and Roderick,T.H.
  TITLE     Linkage analyses using biochemical variants in mice. 3. Linkage
            relationships of eleven biochemical markers
  JOURNAL   Biochem Genet 4 (2), 339-350 (1970)
   PUBMED   5424503
REFERENCE   8  (residues 1 to 673)
  AUTHORS   Burda,D.J. and Center,E.M.
  TITLE     Development of luxoid (lu) skeletal defects in vitro
  JOURNAL   J Embryol Exp Morphol 21 (2), 347-360 (1969)
   PUBMED   5822891
REFERENCE   9  (residues 1 to 673)
  AUTHORS   Center,E.M., Hunter,R.L. and Dodge,A.H.
  TITLE     Effects of the luxoid gene (lu) on liver esterase isozymes of the
            mouse
  JOURNAL   Genetics 55 (2), 349-358 (1967)
   PUBMED   6067640
REFERENCE   10 (residues 1 to 673)
  AUTHORS   Deol,M.S. and Green,M.C.
  TITLE     Snell's waltzer, a new mutation affecting behaviour and the inner
            ear in the mouse
  JOURNAL   Genet Res 8 (3), 339-345 (1966)
   PUBMED   5980120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009741.12 and AC113548.22.
            
            On Jun 21, 2018 this sequence version replaced XP_006510321.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.45009.1, Z47205.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.47 cM"
     Protein         1..673
                     /product="zinc finger and BTB domain-containing protein
                     16"
                     /note="zinc finger protein 145; Green's luxoid"
                     /calculated_mol_wt=74072
     Region          16..122
                     /region_name="BTB_POZ_ZBTB16_PLZF"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 16 (ZBTB16); cd18205"
                     /db_xref="CDD:349514"
     Region          406..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <448..622
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          463..483
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          520..540
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(525,527,529,531..532,535..536,539,553,555,559..560,
                     563..564,567,581,583,585,587..588,591..592,595)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          548..568
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          576..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          604..624
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          632..652
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..673
                     /gene="Zbtb16"
                     /gene_synonym="lu; PLZF; Zfp145"
                     /coded_by="NM_001364543.1:262..2283"
                     /db_xref="CCDS:CCDS23158.1"
                     /db_xref="GeneID:235320"
                     /db_xref="MGI:MGI:103222"
ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 iletiqasdd ndteatmadg ggeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmsig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vkmemmqvde apgqdspgaa essisggmgd kleerskegp gtptrgsvit sarelhygre
      301 esgeqlsppv eagqgppgrq eplappvekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmkaesr plgeqcsvcg velpdneave
      421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
      481 qthtgtdmav fcllcgkrfq aqsalqqhme vhagvrsyic secnrtfpsh talkrhlrsh
      541 tgdhpyecef cgscfrdest lkshkrihtg ekpyecngcg kkfslkhqle thyrvhtgek
      601 pfecklchqr srdysamikh lrthngaspy qcticteycp slssmqkhmk ghkpeeippd
      661 wriektylyl cyv
//
LOCUS       NP_033981                780 aa            linear   ROD 27-AUG-2025
DEFINITION  CD44 antigen isoform a precursor [Mus musculus].
ACCESSION   NP_033981 XP_283773
VERSION     NP_033981.2
DBSOURCE    REFSEQ: accession NM_009851.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 780)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   2  (residues 1 to 780)
  AUTHORS   Deobald,K.N., Steele,S.P., Dominguez,S.R., Whiles,S. and Kawula,T.
  TITLE     Merocytophagy is an integrin-stabilized macrophage response to
            microbes reliant on Syk signaling
  JOURNAL   Front Immunol 16, 1565250 (2025)
   PUBMED   40313956
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 780)
  AUTHORS   Zhang,C., Huang,Q., Ford,N.C., Limjunyawong,N., Lin,Q., Yang,F.,
            Cui,X., Uniyal,A., Liu,J., Mahabole,M., He,H., Wang,X., Duff,I.,
            Wang,Y., Wan,J., Zhu,G., Raja,S.N., Jia,H., Yang,D., Dong,X.,
            Cao,X., Tseng,S.C., He,S. and Guan,Y.
  TITLE     Human birth tissue products as a non-opioid medicine to inhibit
            post-surgical pain
  JOURNAL   Elife 13, 101269 (2024)
   PUBMED   39671234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 780)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (residues 1 to 780)
  AUTHORS   Araujo David,B., Atif,J., Vargas E Silva Castanheira,F., Yasmin,T.,
            Guillot,A., Ait Ahmed,Y., Peiseler,M., Hommes,J.W., Salm,L.,
            Brundler,M.A., Surewaard,B.G.J., Elhenawy,W., MacParland,S.,
            Ginhoux,F., McCoy,K. and Kubes,P.
  TITLE     Kupffer cell reverse migration into the liver sinusoids mitigates
            neonatal sepsis and meningitis
  JOURNAL   Sci Immunol 9 (101), eadq9704 (2024)
   PUBMED   39485859
REFERENCE   6  (residues 1 to 780)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   7  (residues 1 to 780)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 780)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   9  (residues 1 to 780)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   10 (residues 1 to 780)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844155.6, AK045226.1 and AJ251594.1.
            
            On Jan 20, 2006 this sequence version replaced NP_033981.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ251594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     Protein         1..780
                     /product="CD44 antigen isoform a precursor"
                     /note="PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; lymphocyte antigen 24; phagocytic
                     glycoprotein 1; extracellular matrix receptor III; GP90
                     lymphocyte homing/adhesion receptor; phagocytic
                     glycoprotein I"
                     /calculated_mol_wt=83437
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2420
     mat_peptide     25..780
                     /product="CD44 antigen. /id=PRO_0000026689"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
                     /calculated_mol_wt=82937
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Region          30..173
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(42,45..46,72,82..83,104..105,109)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     Site            61
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            104
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            125
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            185
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:P16070; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Region          229..687
                     /region_name="Stem"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Region          253..279
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Region          295..340
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Region          353..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Site            370
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Region          393..593
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Site            412
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P15379.3)"
     Site            427
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            531
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            547
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            605
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Region          630..680
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Site            688..708
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Site            710
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:P16070; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Region          711..729
                     /region_name="Required for interaction with EZR, MSN and
                     RDX and for the co-localization to microvilli.
                     /evidence=ECO:0000269|PubMed:9472040"
                     /note="propagated from UniProtKB/Swiss-Prot (P15379.3)"
     Site            728
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            735
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P15379.3)"
     CDS             1..780
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /coded_by="NM_009851.2:320..2662"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS16472.1"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
ORIGIN      
        1 mdkfwwhtaw glcllqlsla hphqqidlnv tcryagvfhv ekngrysisr teaadlcqaf
       61 nstlptmdqm klalskgfet crygfiegnv viprihpnai caanhtgvyi lvtsntshyd
      121 tycfnasapp eedctsvtdl pnsfdgpvti tivnrdgtry skkgeyrthq edidasniid
      181 ddvssgstie kstpesyilh tylpteqptg dqddsffirs tlatiastvh skshaaaqkq
      241 nnwiwswfgn sqsttqtqep ttsattalmt tpetppkrqe aqnwfswlfq pseskshlht
      301 ttkmpgtesn tnptgwepne enedetdkyp sfsgsgiddd edfisstias tprvsarted
      361 nqdwtqwkpn hsnpevllqt ttrmadidri stsahgenwt pepqppfnnh eyqdeeetph
      421 atsttpnsta eaaatqqetw fqngwqgknp ptpsedshvt egttasahnn hpsqrittqs
      481 qedvswtdff dpishpmgqg hqteskdtds shsttlqpta apnthlvedl nrtgplsvtt
      541 pqshsqnfst lhgepeeden hpttsilpss tksgakdarr ggslptdttt svegytfqyp
      601 dtmengtlfp vtpaktevfg etevtlatds nvnvdgslpg drdsskdsrg ssrtvthgse
      661 laghssanqd sgvtttsgpm rrpqipewli ilasllalal ilavciavns rrrcgqkkkl
      721 vinggngtve drkpselnge asksqemvhl vnkepsetpd qcmtadetrn lqsvdmkigv
//
LOCUS       NP_001276521             337 aa            linear   ROD 27-AUG-2025
DEFINITION  stimulator of interferon genes protein isoform 3 [Mus musculus].
ACCESSION   NP_001276521
VERSION     NP_001276521.1
DBSOURCE    REFSEQ: accession NM_001289592.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 337)
  AUTHORS   Yang,K., Torres-Ramirez,G., Dobbs,N., Han,J., Asahina,M.,
            Fujinawa,R., Song,K., Liu,Y., Lin,W., Oviedo,A., Chen,C., Zhu,L.,
            Mueller,W.F., Lee,K., Suzuki,T. and Yan,N.
  TITLE     The STING pathway drives noninflammatory neurodegeneration in NGLY1
            deficiency
  JOURNAL   J Exp Med 222 (10) (2025)
   PUBMED   40644312
REFERENCE   2  (residues 1 to 337)
  AUTHORS   Zhou,W., Zhou,J.Z., Ahmed,A., Kim,M.J., Guo,C.J. and
            Sonnenberg,G.F.
  CONSRTM   JRI Live Cell Bank
  TITLE     ILC3s sense gut microbiota through STING to initiate immune
            tolerance
  JOURNAL   Immunity 58 (7), 1762-1777 (2025)
   PUBMED   40527323
REFERENCE   3  (residues 1 to 337)
  AUTHORS   Yin,X., Ding,Z., Yu,L., Zhang,X., Gao,Y., Li,Y., Liu,Z. and Fu,Y.X.
  TITLE     Orchestrating intratumoral DC-T cell immunity for enhanced tumor
            control via radiotherapy-activated TLR7/8 prodrugs in mice
  JOURNAL   Nat Commun 16 (1), 6020 (2025)
   PUBMED   40592817
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 337)
  AUTHORS   He,K.Y., Zhao,A., Guo,J.R., Wu,D.H., Liu,H., Gao,F., Liu,M.J.,
            Yang,J.Y., Lei,X.Y., Li,J.Q., Zhang,L., Yan,Z.H., Ding,Q.,
            Huang,Y.W., Cui,R., Jian,Y.P. and Xu,Z.X.
  TITLE     High mobility group A1 (HMGA1) promotes esophageal squamous cell
            carcinoma progression by inhibiting STING-mediated anti-tumor
            immunity
  JOURNAL   Nat Commun 16 (1), 5098 (2025)
   PUBMED   40456764
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 337)
  AUTHORS   Chenuet,P., Mellier,M., Messaoud-Nacer,Y., Culerier,E.,
            Marquant,Q., Fauconnier,L., Rouxel,N., Ledru,A., Rose,S.,
            Ryffel,B., Apetoh,L., Quesniaux,V.F.J. and Togbe,D.
  TITLE     Birch pollen allergen-induced dsDNA release activates cGAS-STING
            signaling and type 2 immune response in mice
  JOURNAL   iScience 28 (5), 112324 (2025)
   PUBMED   40276777
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 337)
  AUTHORS   Ishikawa,H., Ma,Z. and Barber,G.N.
  TITLE     STING regulates intracellular DNA-mediated, type I
            interferon-dependent innate immunity
  JOURNAL   Nature 461 (7265), 788-792 (2009)
   PUBMED   19776740
  REMARK    GeneRIF: STING is essential for host defence against DNA pathogens
            such as HSV-1 and facilitates the adjuvant activity of DNA-based
            vaccines
REFERENCE   7  (residues 1 to 337)
  AUTHORS   Sun,W., Li,Y., Chen,L., Chen,H., You,F., Zhou,X., Zhou,Y., Zhai,Z.,
            Chen,D. and Jiang,Z.
  TITLE     ERIS, an endoplasmic reticulum IFN stimulator, activates innate
            immune signaling through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8653-8658 (2009)
   PUBMED   19433799
REFERENCE   8  (residues 1 to 337)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
REFERENCE   9  (residues 1 to 337)
  AUTHORS   Ishikawa,H. and Barber,G.N.
  TITLE     STING is an endoplasmic reticulum adaptor that facilitates innate
            immune signalling
  JOURNAL   Nature 455 (7213), 674-678 (2008)
   PUBMED   18724357
  REMARK    GeneRIF: identification, following expression cloning, of a
            molecule (STING; stimulator of interferon genes) that appears
            essential for effective innate immune signalling processes
            GeneRIF: STING (TMEM173) is an endoplasmic reticulum adaptor
            protein that facilitates innate immune signaling
            Erratum:[Nature. 2008 Nov 13;456(7219):274]
REFERENCE   10 (residues 1 to 337)
  AUTHORS   Jin,L., Waterman,P.M., Jonscher,K.R., Short,C.M., Reisdorph,N.A.
            and Cambier,J.C.
  TITLE     MPYS, a novel membrane tetraspanner, is associated with major
            histocompatibility complex class II and mediates transduction of
            apoptotic signals
  JOURNAL   Mol Cell Biol 28 (16), 5014-5026 (2008)
   PUBMED   18559423
  REMARK    GeneRIF: A novel plasma membrane tetraspanner (MPYS) that is
            associated with type II major histocompatibility complex and
            mediates its transduction of death signals, is described.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871885.1, AK158458.1, AK012006.1, AK089405.1 and AC132837.11.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158458.1, SRR17253012.3977104.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18818105
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.23 cM"
     Protein         1..337
                     /product="stimulator of interferon genes protein isoform
                     3"
                     /note="mitochondrial mediator of IRF3 activation;
                     stimulator of interferon genes protein; endoplasmic
                     reticulum interferon stimulator; stimulator of interferon
                     protein; transmembrane protein 173"
                     /calculated_mol_wt=37905
     Region          44..295
                     /region_name="TMEM173"
                     /note="Transmembrane protein 173; pfam15009"
                     /db_xref="CDD:464441"
     CDS             1..337
                     /gene="Sting1"
                     /gene_synonym="2610307O08Rik; ERIS; Mita; MPYS; STING;
                     STING-beta; Tmem173"
                     /coded_by="NM_001289592.1:339..1352"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS89220.1"
                     /db_xref="GeneID:72512"
                     /db_xref="MGI:MGI:1919762"
ORIGIN      
        1 mpysnlhpai prprghrsky valiflvasl milwvakdpp nhtlkylalh lashelglll
       61 knlcclaeel chvqsswmfg llvlykslsm llglqsltpa evsavceekk lnvahglaws
      121 yyigylrlil pglqarirmf nqlhnnmlsg agsrrlyilf pldcgvpdnl svvdpnirfr
      181 dmlpqqnidr agiknrvysn svyeilengq pagvcileya tplqtlfams qdakagfsre
      241 drleqaklfc rtleeiledv pesrnncrli vyqeptdgns fslsqevlrh irqeekeevt
      301 mnapmtsvap ppsvlsqepr llisgmdqpl plrtdli
//
LOCUS       NP_112445                211 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-6 isoform 1 precursor [Mus musculus].
ACCESSION   NP_112445
VERSION     NP_112445.1
DBSOURCE    REFSEQ: accession NM_031168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 211)
  AUTHORS   Xing,C., Duan,T., Li,L., Chen,L., Zhang,P., Du,Y., Liu,S.,
            Annaparthi,N., Wang,S., Qian,C., Wang,H.Y. and Wang,R.F.
  TITLE     TH17 cells regulate chemokine expression in epithelial cells
            through C/EBPbeta and dictate host sensitivity to colitis and
            cancer immunity
  JOURNAL   Sci Adv 11 (31), eads3530 (2025)
   PUBMED   40749055
REFERENCE   2  (residues 1 to 211)
  AUTHORS   Gonzalez-Vila,A., Ibrahim-Alasoufi,A.M., Luengo-Mateos,M.,
            Pardo-Garcia,V., Diaz-Lopez,A., Fernandez-Rodriguez,B.,
            Poutanen,M., Ohlsson,C., Tena-Sempere,M., Dieguez-Gonzalez,C.,
            Garcia-Garcia,M.D.C. and Barca-Mayo,O.
  TITLE     IL-6 decodes sex and diet-dependent circadian and metabolic rhythms
  JOURNAL   Mol Metab 97, 102171 (2025)
   PUBMED   40412648
  REMARK    Erratum:[Mol Metab. 2025 Sep;99:102198. doi:
            10.1016/j.molmet.2025.102198. PMID: 40617253]
REFERENCE   3  (residues 1 to 211)
  AUTHORS   Li,X., Li,X., Liu,C., Li,Z., Ding,K., Wang,Y., Gu,N., Xie,L. and
            Chen,Z.
  TITLE     YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis
  JOURNAL   Adv Sci (Weinh), e05725 (2025) In press
   PUBMED   40536447
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 211)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   5  (residues 1 to 211)
  AUTHORS   Kong,W., Lu,W.J., Dubey,M., Suryawanshi,R.K., Vijayakumar,S.,
            Jeong,Y., Gombar,S., Diehn,M., Shin,K., Ott,M., Chien,Y.H.,
            Sarin,K.Y., Desai,T.J. and Beachy,P.A.
  TITLE     Neuroendocrine cells orchestrate regeneration through Desert
            hedgehog signaling
  JOURNAL   Cell (2025) In press
   PUBMED   40494346
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 211)
  AUTHORS   Chin,H., Mock,B., Kim,H.L., Kim,H. and Kozak,C.A.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (residues 1 to 211)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   8  (residues 1 to 211)
  AUTHORS   Vandevoorde,V., Haegeman,G. and Fiers,W.
  TITLE     TNF-mediated IL6 gene expression and cytotoxicity are co-inducible
            in TNF-resistant L929 cells
  JOURNAL   FEBS Lett 302 (3), 235-238 (1992)
   PUBMED   1318227
REFERENCE   9  (residues 1 to 211)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   10 (residues 1 to 211)
  AUTHORS   Bodine,D.M., Orlic,D., Birkett,N.C., Seidel,N.E. and Zsebo,K.M.
  TITLE     Stem cell factor increases colony-forming unit-spleen number in
            vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as
            a single factor
  JOURNAL   Blood 79 (4), 913-919 (1992)
   PUBMED   1371079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112933.16 and AK150440.1.
            
            Summary: This gene encodes a member of the interleukin family of
            cytokines that have important functions in immune response,
            hematopoiesis, inflammation and the acute phase response. The
            ectopic overexpression of the encoded protein in mice results in
            excessive plasma cells in circulation, leading to death. Mice
            lacking the encoded protein exhibit abnormalities in hepatic acute
            phase response, some immune mechanisms, bone resorption in response
            to estrogen, liver regeneration and wound healing. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150440.1, J03783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.7 cM"
     Protein         1..211
                     /product="interleukin-6 isoform 1 precursor"
                     /note="interleukin HP-1; B-cell hybridoma growth factor"
                     /calculated_mol_wt=21735
     sig_peptide     1..24
                     /note="/evidence=ECO:0000269|PubMed:2948184,
                     ECO:0000269|PubMed:3262059; propagated from
                     UniProtKB/Swiss-Prot (P08505.1)"
                     /calculated_mol_wt=2667
     mat_peptide     25..211
                     /product="Interleukin-6. /id=PRO_0000015588"
                     /note="propagated from UniProtKB/Swiss-Prot (P08505.1)"
                     /calculated_mol_wt=21735
     Region          27..210
                     /region_name="IL6"
                     /note="Interleukin-6/G-CSF/MGF family; pfam00489"
                     /db_xref="CDD:395393"
     CDS             1..211
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /coded_by="NM_031168.2:79..714"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19153.1"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
ORIGIN      
        1 mkflsardfh pvaflglmlv tttafptsqv rrgdftedtt pnrpvyttsq vgglithvlw
       61 eivemrkelc ngnsdcmnnd dalaennlkl peiqrndgcy qtgynqeicl lkissglley
      121 hsyleymknn lkdnkkdkar vlqrdtetli hifnqevkdl hkivlptpis nalltdkles
      181 qkewlrtkti qfilksleef lkvtlrstrq t
//
LOCUS       NP_001157991             628 aa            linear   ROD 27-AUG-2025
DEFINITION  catenin alpha-3 isoform 2 [Mus musculus].
ACCESSION   NP_001157991
VERSION     NP_001157991.1
DBSOURCE    REFSEQ: accession NM_001164519.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 628)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 628)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
REFERENCE   3  (residues 1 to 628)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   4  (residues 1 to 628)
  AUTHORS   Weng,A., Rabin,E.E., Flozak,A.S., Chiarella,S.E., Aillon,R.P. and
            Gottardi,C.J.
  TITLE     Alpha-T-catenin is expressed in peripheral nerves as a constituent
            of Schwann cell adherens junctions
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36420826
  REMARK    GeneRIF: Alpha-T-catenin is expressed in peripheral nerves as a
            constituent of Schwann cell adherens junctions.
REFERENCE   5  (residues 1 to 628)
  AUTHORS   Zhang,Y.
  TITLE     SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells
  JOURNAL   Cell Tissue Res 389 (1), 145-157 (2022)
   PUBMED   35536443
  REMARK    GeneRIF: SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells.
REFERENCE   6  (residues 1 to 628)
  AUTHORS   Goossens,S., Janssens,B., Bonne,S., De Rycke,R., Braet,F., van
            Hengel,J. and van Roy,F.
  TITLE     A unique and specific interaction between alphaT-catenin and
            plakophilin-2 in the area composita, the mixed-type junctional
            structure of cardiac intercalated discs
  JOURNAL   J Cell Sci 120 (Pt 12), 2126-2136 (2007)
   PUBMED   17535849
  REMARK    GeneRIF: By providing an extra link between the cadherin-catenin
            complex and intermediate filaments, the binding of alphaT-catenin
            to plakophilin-2 is proposed to be a means of modulating and
            strengthening cell-cell adhesion between cardiac muscle cells.
REFERENCE   7  (residues 1 to 628)
  AUTHORS   Goossens,S., Janssens,B., Vanpoucke,G., De Rycke,R., van Hengel,J.
            and van Roy,F.
  TITLE     Truncated isoform of mouse alphaT-catenin is testis-restricted in
            expression and function
  JOURNAL   FASEB J 21 (3), 647-655 (2007)
   PUBMED   17185752
REFERENCE   8  (residues 1 to 628)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   9  (residues 1 to 628)
  AUTHORS   Janssens,B., Mohapatra,B., Vatta,M., Goossens,S., Vanpoucke,G.,
            Kools,P., Montoye,T., van Hengel,J., Bowles,N.E., van Roy,F. and
            Towbin,J.A.
  TITLE     Assessment of the CTNNA3 gene encoding human alpha T-catenin
            regarding its involvement in dilated cardiomyopathy
  JOURNAL   Hum Genet 112 (3), 227-236 (2003)
   PUBMED   12596047
REFERENCE   10 (residues 1 to 628)
  AUTHORS   Janssens,B., Goossens,S., Staes,K., Gilbert,B., van Hengel,J.,
            Colpaert,C., Bruyneel,E., Mareel,M. and van Roy,F.
  TITLE     alphaT-catenin: a novel tissue-specific beta-catenin-binding
            protein mediating strong cell-cell adhesion
  JOURNAL   J Cell Sci 114 (Pt 17), 3177-3188 (2001)
   PUBMED   11590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153926.10, AC158604.5, AC158806.4, AC153513.6, AC153514.8,
            AC158638.15, AC153511.4 and AC113544.9.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ380430.1, SRR5189685.154885.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..628
                     /product="catenin alpha-3 isoform 2"
                     /note="alpha-catenin-like protein; alpha T-catenin;
                     catenin (cadherin associated protein), alpha 3;
                     cadherin-associated protein; alphaT-catenin"
                     /calculated_mol_wt=70284
     Region          <15..589
                     /region_name="Vinculin"
                     /note="Vinculin family; pfam01044"
                     /db_xref="CDD:460040"
     CDS             1..628
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /coded_by="NM_001164519.1:120..2006"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:216033"
                     /db_xref="MGI:MGI:2661445"
ORIGIN      
        1 mmlapkedrl nanknlivln pltvteedvr pslekrleai isgaallads sctrdlhrer
       61 iiaecnairq alqdllteym sntgktersn tlntaivnms kktrdlrrql rkaiidhisd
      121 sfldttvpll vlieaakngr vkeikdyaai fhehtgrlve vanlacsmst nedgikivri
      181 aanhletlcp qiinaalala srpksqvvkn tmemykrtwe hyihvlteav dditsiddfl
      241 avseshiled vnkciialrd qdadnldraa gairgraarv ahivagemds yepgaytegv
      301 mrnvnfltst vipefvtqvn valdalskns ltalddnqfv diskkiydti hdircsvmmi
      361 rtpeeledvs dleddhevrs htsiqtegkt drakmtqlpe aekekiaeqv adfkkvkskl
      421 daeieiwddt sndiivlakk mcmimmemtd ftrgkgplkh ttdviyaakm isesgsrmdv
      481 larqianqcp dppckqdlla yleqikfysh qlkicsqvka eiqnlggeli vsaldsvtsl
      541 iqaaknlmna vvqtvkmsyi astkiiriqs sagprhpvvm wrmkapakkp likrekpeet
      601 waavrrgsak kkihpvqvms efrgrqvy
//
LOCUS       NP_034045                373 aa            linear   ROD 27-AUG-2025
DEFINITION  C-C chemokine receptor type 2 [Mus musculus].
ACCESSION   NP_034045
VERSION     NP_034045.1
DBSOURCE    REFSEQ: accession NM_009915.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Li,W., Zhu,H., Zou,X., Ye,H., Zhong,J., Xiang,S., Lou,Y., Mao,J.,
            Qi,L., Hu,X., Zhang,Y., Hou,J., Wang,B., Bode,C., Hoeft,A., Li,X.,
            Zhang,K., Colonna,M. and Fang,X.
  TITLE     A brain-to-lung signal from GABAergic neurons to ADRB2+
            interstitial macrophages promotes pulmonary inflammatory responses
  JOURNAL   Immunity 58 (8), 2069-2085 (2025)
   PUBMED   40466637
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Wu,J., Wang,Y., Li,X., Ouyang,P., Cai,Y., He,Y., Zhang,M., Luan,X.,
            Jin,Y., Wang,J., Xiao,Y., Liang,Y., Xie,F., Shu,Y., Hu,J.,
            Chang,C., Jiang,J., Wu,D., Zhao,Y., Liu,T., Li,Y., Huang,X., Li,Y.,
            Zhang,J., Cao,Y., Cheng,X., Mao,Y., Rao,Y., Cao,L. and Peng,B.
  TITLE     Microglia replacement halts the progression of microgliopathy in
            mice and humans
  JOURNAL   Science 389 (6756), eadr1015 (2025)
   PUBMED   40638739
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Mohapatra,A., Norris,B.A., Howard,Z. and Ernst,J.D.
  TITLE     CCR2 recruits monocytes to the lung, while CX3CR1 modulates
            positioning of CD11cpos cells in the lymph node during pulmonary
            tuberculosis
  JOURNAL   mBio 16 (7), e0123725 (2025)
   PUBMED   40497732
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   6  (residues 1 to 373)
  AUTHORS   Sarafi,M.N., Garcia-Zepeda,E.A., MacLean,J.A., Charo,I.F. and
            Luster,A.D.
  TITLE     Murine monocyte chemoattractant protein (MCP)-5: a novel CC
            chemokine that is a structural and functional homologue of human
            MCP-1
  JOURNAL   J Exp Med 185 (1), 99-109 (1997)
   PUBMED   8996246
REFERENCE   7  (residues 1 to 373)
  AUTHORS   Heesen,M., Tanabe,S., Berman,M.A., Yoshizawa,I., Luo,Y., Kim,R.J.,
            Post,T.W., Gerard,C. and Dorf,M.E.
  TITLE     Mouse astrocytes respond to the chemokines MCP-1 and KC, but
            reverse transcriptase-polymerase chain reaction does not detect
            mRNA for the KC or new MCP-1 receptor
  JOURNAL   J Neurosci Res 45 (4), 382-391 (1996)
   PUBMED   8872898
REFERENCE   8  (residues 1 to 373)
  AUTHORS   Kurihara,T. and Bravo,R.
  TITLE     Cloning and functional expression of mCCR2, a murine receptor for
            the C-C chemokines JE and FIC
  JOURNAL   J Biol Chem 271 (20), 11603-11607 (1996)
   PUBMED   8662823
REFERENCE   9  (residues 1 to 373)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
REFERENCE   10 (residues 1 to 373)
  AUTHORS   Kozak,C.A., Gao,J.L. and Murphy,P.M.
  TITLE     Mapping of the mouse macrophage inflammatory protein-1 alpha
            receptor gene Scya3r and two related mouse beta chemokine
            receptor-like genes to chromosome 9
  JOURNAL   Genomics 29 (1), 294-296 (1995)
   PUBMED   8530091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U56819.1, AK138599.1 and AK162705.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U56819.1, BB645326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 75.05 cM"
     Protein         1..373
                     /product="C-C chemokine receptor type 2"
                     /note="chemokine (C-C) receptor 2; CCR-2; C-C CKR-2; MCP-1
                     receptor; JE/FIC receptor; MIP-1 alphaR; chemoattractant
                     protein-1 receptor; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C
                     CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1
                     RECEPTOR); chemokine (C-C motif) receptor 2"
                     /calculated_mol_wt=42652
     Site            56..83
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Region          57..329
                     /region_name="7tmA_CCR5_CCR2"
                     /note="CC chemokine receptor types 5 and 2, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15184"
                     /db_xref="CDD:341338"
     Region          57..83
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341338"
     Site            order(62,111,114,130,133..134,203..207,212,215..216,272,
                     279,282,293,297,300..301,304)
                     /site_type="other"
                     /note="putative chemokine binding site [polypeptide
                     binding]"
                     /db_xref="CDD:341338"
     Site            order(76,80,90,94,151,250,254,257,318,322,325,328)
                     /site_type="other"
                     /note="allosteric modulator binding site [chemical
                     binding]"
                     /db_xref="CDD:341338"
     Region          90..115
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341338"
     Site            94..114
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Region          126..156
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341338"
     Site            128..149
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK2.
                     /evidence=ECO:0000250|UniProtKB:P41597; propagated from
                     UniProtKB/Swiss-Prot (P51683.2)"
     Site            167..191
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Region          168..190
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341338"
     Region          212..241
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341338"
     Site            220..239
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Region          249..279
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341338"
     Site            257..281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     Region          297..322
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341338"
     Site            299..322
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P51683.2)"
     CDS             1..373
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /coded_by="NM_009915.2:134..1255"
                     /db_xref="CCDS:CCDS23669.1"
                     /db_xref="GeneID:12772"
                     /db_xref="MGI:MGI:106185"
ORIGIN      
        1 mednnmlpqf ihgilstshs lftrsiqeld egattpydyd dgepchktsv kqigawilpp
       61 lyslvfifgf vgnmlviiil igckklksmt diyllnlais dllflltlpf wahyaanewv
      121 fgnimckvft glyhigyfgg iffiilltid rylaivhavf alkartvtfg vitsvvtwvv
      181 avfaslpgii ftkskqddhh ytcgpyftql wknfqtimrn ilslilpllv mvicysgilh
      241 tlfrcrnekk rhravrlifa imivyflfwt pynivlfltt fqeslgmsnc vidkhldqam
      301 qvtetlgmth ccinpviyaf vgekfrryls iffrkhiakr lckqcpvfyr etadrvsstf
      361 tpstgeqevs vgl
//
LOCUS       NP_001333993              90 aa            linear   ROD 27-AUG-2025
DEFINITION  histone H2A.V isoform 2 [Mus musculus].
ACCESSION   NP_001333993 XP_017170326
VERSION     NP_001333993.1
DBSOURCE    REFSEQ: accession NM_001347064.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 90)
  AUTHORS   Li,W., Morarach,K., Liu,Z., Banerjee,S., Chen,Y., Harb,A.L.,
            Kosareff,J.M., Hall,C.R., Lopez-Redondo,F., Jalalvand,E.,
            Mohamed,S.H., Mikhailova,A., Linden,D.R. and Marklund,U.
  TITLE     The transcriptomes, connections and development of submucosal
            neuron classes in the mouse small intestine
  JOURNAL   Nat Neurosci 28 (6), 1146-1159 (2025)
   PUBMED   40442499
REFERENCE   2  (residues 1 to 90)
  AUTHORS   Xu,X., Chen,Q., Huang,Q., Cox,T.C., Zhu,H., Hu,J., Han,X., Meng,Z.,
            Wang,B., Liao,Z., Xu,W., Xiao,B., Lang,R., Liu,J., Huang,J.,
            Tang,X., Wang,J., Li,Q., Liu,T., Zhang,Q., Antonarakis,S.E.,
            Zhang,J., Fan,X., Liu,H. and Zhang,Y.B.
  TITLE     Auricular malformations are driven by copy number variations in a
            hierarchical enhancer cluster and a dominant enhancer recapitulates
            human pathogenesis
  JOURNAL   Nat Commun 16 (1), 4598 (2025)
   PUBMED   40382324
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 90)
  AUTHORS   Zhou,Y., Li,M., Lin,S., Zhu,Z., Zhuang,Z., Cui,S., Chen,L.,
            Zhang,R., Wang,X., Shen,B., Chen,C. and Yang,R.
  TITLE     Mechanical sensing protein PIEZO1 controls osteoarthritis via
            glycolysis mediated mesenchymal stem cells-Th17 cells crosstalk
  JOURNAL   Cell Death Dis 16 (1), 231 (2025)
   PUBMED   40169556
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 90)
  AUTHORS   Shen,Z., Zhang,R., Chen,X., Yang,G., Si,Y., Yan,T., Chen,S.,
            Cheng,B., Wu,X., Chen,D., Zhang,D., Xiao,G., Zhu,J.K. and Wang,S.
  TITLE     An atlas of early human mandibular endochondral and osteogenic
            paracrine signaling regions of Meckel's cartilage
  JOURNAL   Proc Natl Acad Sci U S A 122 (12), e2420466122 (2025)
   PUBMED   40096606
REFERENCE   5  (residues 1 to 90)
  AUTHORS   Midla,S.C., Omi-Sugihara,M., Cha,M., Chen,C., Cavalcante,R.C.,
            Pan,H., Mishina,Y. and Ueharu,H.
  TITLE     Augmented Bone Morphogenetic Protein Signaling During TMJ
            Development Alters Morphology in a Timepoint-Dependent Manner
  JOURNAL   Int J Mol Sci 26 (4), 1655 (2025)
   PUBMED   40004119
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 90)
  AUTHORS   Dryhurst,D., Ishibashi,T., Rose,K.L., Eirin-Lopez,J.M.,
            McDonald,D., Silva-Moreno,B., Veldhoen,N., Helbing,C.C.,
            Hendzel,M.J., Shabanowitz,J., Hunt,D.F. and Ausio,J.
  TITLE     Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in
            vertebrates
  JOURNAL   BMC Biol 7, 86 (2009)
   PUBMED   20003410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 90)
  AUTHORS   Brault,V., Moore,R., Kutsch,S., Ishibashi,M., Rowitch,D.H.,
            McMahon,A.P., Sommer,L., Boussadia,O. and Kemler,R.
  TITLE     Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion
            results in dramatic brain malformation and failure of craniofacial
            development
  JOURNAL   Development 128 (8), 1253-1264 (2001)
   PUBMED   11262227
REFERENCE   8  (residues 1 to 90)
  AUTHORS   Chai,Y., Jiang,X., Ito,Y., Bringas,P. Jr., Han,J., Rowitch,D.H.,
            Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cranial neural crest during tooth and
            mandibular morphogenesis
  JOURNAL   Development 127 (8), 1671-1679 (2000)
   PUBMED   10725243
REFERENCE   9  (residues 1 to 90)
  AUTHORS   Jiang,X., Rowitch,D.H., Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cardiac neural crest
  JOURNAL   Development 127 (8), 1607-1616 (2000)
   PUBMED   10725237
REFERENCE   10 (residues 1 to 90)
  AUTHORS   Danielian,P.S., Muccino,D., Rowitch,D.H., Michael,S.K. and
            McMahon,A.P.
  TITLE     Modification of gene activity in mouse embryos in utero by a
            tamoxifen-inducible form of Cre recombinase
  JOURNAL   Curr Biol 8 (24), 1323-1326 (1998)
   PUBMED   9843687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ069840.1, BC028539.1,
            AL646020.15 and AI851486.1.
            
            On Nov 15, 2016 this sequence version replaced XP_017170326.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 2, which lacks an internal in-frame segment and is shorter,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4441266.1,
                                           SRR7652917.530128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            replication-independent histone :: PMID: 20003410
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..90
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.01 cM"
     Protein         1..90
                     /product="histone H2A.V isoform 2"
                     /note="histone H2A.F/Z; histone H2A.V; H2A histone family,
                     member V; H2A.Z variant histone 2"
                     /calculated_mol_wt=9244
     Region          3..90
                     /region_name="PTZ00017"
                     /note="histone H2A; Provisional"
                     /db_xref="CDD:185399"
     CDS             1..90
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /coded_by="NM_001347064.1:105..377"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS83779.1"
                     /db_xref="GeneID:77605"
                     /db_xref="MGI:MGI:1924855"
ORIGIN      
        1 maggkagkds gkakakavsr sqraglqvle lagnaskdlk vkritprhlq lairgdeeld
       61 slikatiagg gviphihksl igkkgqqkta
//
LOCUS       NP_033548                352 aa            linear   ROD 27-AUG-2025
DEFINITION  protein Wnt-3a precursor [Mus musculus].
ACCESSION   NP_033548
VERSION     NP_033548.1
DBSOURCE    REFSEQ: accession NM_009522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 352)
  AUTHORS   Shinozuka,T., Okubo,T., Sasai,N. and Takada,S.
  TITLE     Wnt-dependent mechanism of the apical constriction of roof plate
            cells in developing mouse spinal cord
  JOURNAL   Front Cell Dev Biol 13, 1571770 (2025)
   PUBMED   40692752
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 352)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 352)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 352)
  AUTHORS   Hayashi,S., Suzuki,H., Takada,S. and Takemoto,T.
  TITLE     Wnt3a is an early regulator of the Wolffian duct directionality via
            the regulation of apicobasal cell polarity
  JOURNAL   Dev Biol 522, 136-142 (2025)
   PUBMED   40154784
REFERENCE   5  (residues 1 to 352)
  AUTHORS   Elorriaga,V., Bouloudi,B., Delberghe,E., Saillour,Y., Morel,J.S.,
            Azzam,P., Moreau,M.X., Stottmann,R., Bahi-Buisson,N., Pierani,A.,
            Spassky,N. and Causeret,F.
  TITLE     Differential contribution of P73+ Cajal-Retzius cells and Reelin to
            cortical morphogenesis
  JOURNAL   Development 152 (9) (2025)
   PUBMED   40207459
REFERENCE   6  (residues 1 to 352)
  AUTHORS   McMahon,A.P., Joyner,A.L., Bradley,A. and McMahon,J.A.
  TITLE     The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from
            stepwise deletion of engrailed-expressing cells by 9.5 days
            postcoitum
  JOURNAL   Cell 69 (4), 581-595 (1992)
   PUBMED   1534034
REFERENCE   7  (residues 1 to 352)
  AUTHORS   Roelink,H. and Nusse,R.
  TITLE     Expression of two members of the Wnt family during mouse
            development--restricted temporal and spatial patterns in the
            developing neural tube
  JOURNAL   Genes Dev 5 (3), 381-388 (1991)
   PUBMED   2001840
REFERENCE   8  (residues 1 to 352)
  AUTHORS   Henry,E.W. and Sidman,R.L.
  TITLE     Long lives for homozygous trembler mutant mice despite virtual
            absence of peripheral nerve myelin
  JOURNAL   Science 241 (4863), 344-346 (1988)
   PUBMED   3388045
REFERENCE   9  (residues 1 to 352)
  AUTHORS   Lane,P.W., Ganser,A.L., Kerner,A.L. and White,W.F.
  TITLE     Spasmodic, a mutation on chromosome 11 in the mouse
  JOURNAL   J Hered 78 (6), 353-356 (1987)
   PUBMED   3429842
REFERENCE   10 (residues 1 to 352)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713994.15.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56842.1, SRR10662772.1060964.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.17 cM"
     Protein         1..352
                     /product="protein Wnt-3a precursor"
                     /note="protein Wnt-3a; vestigial tail; wingless-related
                     MMTV integration site 3A"
                     /calculated_mol_wt=37385
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1890
     mat_peptide     19..352
                     /product="Protein Wnt-3a. /id=PRO_0000041419"
                     /note="propagated from UniProtKB/Swiss-Prot (P27467.1)"
                     /calculated_mol_wt=37385
     Site            26..27
                     /site_type="cleavage"
                     /note="Cleavage, by TIKI1 and TIKI2.
                     /evidence=ECO:0000269|PubMed:22726442; propagated from
                     UniProtKB/Swiss-Prot (P27467.1)"
     Region          39..352
                     /region_name="Wnt_Wnt3_Wnt3a"
                     /note="Wnt domain found in proto-oncogene Wnt-3 and
                     similar proteins; cd19335"
                     /db_xref="CDD:381709"
     Site            87
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27467.1)"
     Site            order(204..205,208..210,218,331,333,335,337)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381709"
     Site            298
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27467.1)"
     CDS             1..352
                     /gene="Wnt3a"
                     /gene_synonym="vt; Wnt-3a"
                     /coded_by="NM_009522.3:107..1165"
                     /db_xref="CCDS:CCDS24766.1"
                     /db_xref="GeneID:22416"
                     /db_xref="MGI:MGI:98956"
ORIGIN      
        1 maplgyllvl cslkqalgsy piwwslavgp qysslstqpi lcasipglvp kqlrfcrnyv
       61 eimpsvaegv kagiqecqhq frgrrwnctt vsnslaifgp vldkatresa fvhaiasagv
      121 afavtrscae gsaaicgcss rlqgspgegw kwggcsedie fggmvsrefa darenrpdar
      181 samnrhnnea grqaiashmh lkckchglsg scevktcwws qpdfrtigdf lkdkydsase
      241 mvvekhresr gwvetlrpry tyfkvpterd lvyyeaspnf cepnpetgsf gtrdrtcnvs
      301 shgidgcdll ccgrghnart errrekchcv fhwccyvscq ectrvydvht ck
//
LOCUS       NP_001403537             707 aa            linear   ROD 27-AUG-2025
DEFINITION  B-cell lymphoma 6 protein homolog isoform 1 [Mus musculus].
ACCESSION   NP_001403537 XP_030104801
VERSION     NP_001403537.1
DBSOURCE    REFSEQ: accession NM_001416608.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 707)
  AUTHORS   Gribonika,I., Band,V.I., Chi,L., Perez-Chaparro,P.J., Link,V.M.,
            Ansaldo,E., Oguz,C., Bousbaine,D., Fischbach,M.A. and Belkaid,Y.
  TITLE     Skin autonomous antibody production regulates host-microbiota
            interactions
  JOURNAL   Nature 638 (8052), 1043-1053 (2025)
   PUBMED   39662506
  REMARK    Erratum:[Nature. 2025 Mar;639(8053):E6. doi:
            10.1038/s41586-025-08776-8. PMID: 39972149]
REFERENCE   2  (residues 1 to 707)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   3  (residues 1 to 707)
  AUTHORS   Fahlquist-Hagert,C., Wittenborn,T.R., Pedersen,M.K., Jensen,L. and
            Degn,S.E.
  TITLE     T-follicular regulatory cells expand to control germinal center
            plasma cell output but fail to curb autoreactivity
  JOURNAL   iScience 27 (10), 110887 (2024)
   PUBMED   39319261
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 707)
  AUTHORS   Li,Y., Ramirez-Suastegui,C., Harris,R., Castaneda-Castro,F.E.,
            Ascui,G., Perez-Jeldres,T., Diaz,A., Morong,C., Giles,D.A.,
            Chai,J., Seumois,G., Sanchez-Elsner,T., Cummings,F., Kronenberg,M.
            and Vijayanand,P.
  TITLE     Stem-like T cells are associated with the pathogenesis of
            ulcerative colitis in humans
  JOURNAL   Nat Immunol 25 (7), 1231-1244 (2024)
   PUBMED   38898157
REFERENCE   5  (residues 1 to 707)
  AUTHORS   Dent,A.L., Shaffer,A.L., Yu,X., Allman,D. and Staudt,L.M.
  TITLE     Control of inflammation, cytokine expression, and germinal center
            formation by BCL-6
  JOURNAL   Science 276 (5312), 589-592 (1997)
   PUBMED   9110977
REFERENCE   6  (residues 1 to 707)
  AUTHORS   Bernardin,F., Collyn-d'Hooghe,M., Quief,S., Bastard,C., Leprince,D.
            and Kerckaert,J.P.
  TITLE     Small deletions occur in highly conserved regions of the LAZ3/BCL6
            major translocation cluster in one case of non-Hodgkin's lymphoma
            without 3q27 translocation
  JOURNAL   Oncogene 14 (7), 849-855 (1997)
   PUBMED   9047392
REFERENCE   7  (residues 1 to 707)
  AUTHORS   Yoshida,T., Fukuda,T., Okabe,S., Hatano,M., Miki,T., Hirosawa,S.,
            Miyasaka,N., Isono,K. and Tokuhisa,T.
  TITLE     The BCL6 gene is predominantly expressed in keratinocytes at their
            terminal differentiation stage
  JOURNAL   Biochem Biophys Res Commun 228 (1), 216-220 (1996)
   PUBMED   8912662
REFERENCE   8  (residues 1 to 707)
  AUTHORS   Liao,X., Gilbert,D.J., Dent,A., Staudt,L.M., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Mapping of the mouse Bcl6 gene to chromosome 16
  JOURNAL   Mamm Genome 7 (8), 621-622 (1996)
   PUBMED   8678989
REFERENCE   9  (residues 1 to 707)
  AUTHORS   Allman,D., Jain,A., Dent,A., Maile,R.R., Selvaggi,T., Kehry,M.R.
            and Staudt,L.M.
  TITLE     BCL-6 expression during B-cell activation
  JOURNAL   Blood 87 (12), 5257-5268 (1996)
   PUBMED   8652841
REFERENCE   10 (residues 1 to 707)
  AUTHORS   Fukuda,T., Miki,T., Yoshida,T., Hatano,M., Ohashi,K., Hirosawa,S.
            and Tokuhisa,T.
  TITLE     The murine BCL6 gene is induced in activated lymphocytes as an
            immediate early gene
  JOURNAL   Oncogene 11 (8), 1657-1663 (1995)
   PUBMED   7478591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158397.2.
            
            On Feb 13, 2023 this sequence version replaced XP_030104801.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.1221560.1,
                                           SRR10662773.103407.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 15.26 cM"
     Protein         1..707
                     /product="B-cell lymphoma 6 protein homolog isoform 1"
                     /note="B-cell lymphoma 6 protein homolog; B-cell
                     leukemia/lymphoma 5"
                     /calculated_mol_wt=78851
     Region          8..125
                     /region_name="BTB_POZ_ZBTB27_BCL6"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in B-cell lymphoma
                     6 protein (BCL-6); cd18331"
                     /db_xref="CDD:349640"
     Site            order(8..14,17..18,21,24,28,51..55,58,114..116,120)
                     /site_type="other"
                     /note="co-repressor binding site [polypeptide binding]"
                     /db_xref="CDD:349640"
     Site            order(8..11,14..16,18..19,21..22,25,28,30..31,46..48,
                     51..53,58,67,89..90,93..97,116,120)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:349640"
     Site            order(21,24..25,28,51..55,58,113..115)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:349640"
     Region          <179..429
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          275..350
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK1.
                     /evidence=ECO:0000250|UniProtKB:P41182; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          377..380
                     /region_name="Required for interaction with NuRD complex
                     and for transcriptional repressor activity"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            380
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P41182; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          405..469
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41183.1)"
     Site            405
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P41183.1)"
     Region          521..542
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          561..586
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          577..597
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(582,584,586,588..589,592..593,596,610,612,616..617,
                     620..621,624,638,640,642,644..645,648..649,652)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          589..614
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          605..625
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          617..642
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          633..653
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          646..670
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          661..679
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..707
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /coded_by="NM_001416608.1:223..2346"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="GeneID:12053"
                     /db_xref="MGI:MGI:107187"
ORIGIN      
        1 maspadsciq ftrhasdvll nlnrlrsrdi ltdvvivvsr eqfrahktvl macsglfysi
       61 ftdqlkcnls vinldpeisp egfcilldfm ytsrlnlreg nimavmttam ylqmehvvdt
      121 crkfikasea emapalkppr eeflnsrmlm phdimayrgr evvennmplr ntpgcesraf
      181 applysglst ppasypmysh lplstflfsd eelrdaprmp vanpfpkera lpcdsarqvp
      241 neysrpamev spslchsniy spkeavpeea rsdihysvpe gpkpavpsar napyfpcdka
      301 skeeerpsse deialhfepp naplnrkglv spqspqksdc qpnsptescs sknacilqas
      361 gsppaksptd pkacnwkkyk fivlnslnqn akpegseqae lgrlsprayp appacqppme
      421 panldlqspt klsasgedst ipqasrlnnl vnrslagspr ssseshsply mhppkctscg
      481 sqspqhtemc lhtagptfpe emgetqseys dsscengtff cnecdcrfse easlkrhtlq
      541 thsdkpykcd rcqasfrykg nlashktvht gekpyrcnic gaqfnrpanl kthtrihsge
      601 kpykcetcga rfvqvahlra hvlihtgekp ypceicgtrf rhlqtlkshl rihtgekpyh
      661 cekcnlhfrh ksqlrlhlrq khgaitntkv qyrvsaadlp pelpkac
//
LOCUS       NP_084214                128 aa            linear   ROD 27-AUG-2025
DEFINITION  histone H2A.V isoform 1 [Mus musculus].
ACCESSION   NP_084214 XP_001476118 XP_912773
VERSION     NP_084214.1
DBSOURCE    REFSEQ: accession NM_029938.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 128)
  AUTHORS   Li,W., Morarach,K., Liu,Z., Banerjee,S., Chen,Y., Harb,A.L.,
            Kosareff,J.M., Hall,C.R., Lopez-Redondo,F., Jalalvand,E.,
            Mohamed,S.H., Mikhailova,A., Linden,D.R. and Marklund,U.
  TITLE     The transcriptomes, connections and development of submucosal
            neuron classes in the mouse small intestine
  JOURNAL   Nat Neurosci 28 (6), 1146-1159 (2025)
   PUBMED   40442499
REFERENCE   2  (residues 1 to 128)
  AUTHORS   Xu,X., Chen,Q., Huang,Q., Cox,T.C., Zhu,H., Hu,J., Han,X., Meng,Z.,
            Wang,B., Liao,Z., Xu,W., Xiao,B., Lang,R., Liu,J., Huang,J.,
            Tang,X., Wang,J., Li,Q., Liu,T., Zhang,Q., Antonarakis,S.E.,
            Zhang,J., Fan,X., Liu,H. and Zhang,Y.B.
  TITLE     Auricular malformations are driven by copy number variations in a
            hierarchical enhancer cluster and a dominant enhancer recapitulates
            human pathogenesis
  JOURNAL   Nat Commun 16 (1), 4598 (2025)
   PUBMED   40382324
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 128)
  AUTHORS   Zhou,Y., Li,M., Lin,S., Zhu,Z., Zhuang,Z., Cui,S., Chen,L.,
            Zhang,R., Wang,X., Shen,B., Chen,C. and Yang,R.
  TITLE     Mechanical sensing protein PIEZO1 controls osteoarthritis via
            glycolysis mediated mesenchymal stem cells-Th17 cells crosstalk
  JOURNAL   Cell Death Dis 16 (1), 231 (2025)
   PUBMED   40169556
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 128)
  AUTHORS   Shen,Z., Zhang,R., Chen,X., Yang,G., Si,Y., Yan,T., Chen,S.,
            Cheng,B., Wu,X., Chen,D., Zhang,D., Xiao,G., Zhu,J.K. and Wang,S.
  TITLE     An atlas of early human mandibular endochondral and osteogenic
            paracrine signaling regions of Meckel's cartilage
  JOURNAL   Proc Natl Acad Sci U S A 122 (12), e2420466122 (2025)
   PUBMED   40096606
REFERENCE   5  (residues 1 to 128)
  AUTHORS   Midla,S.C., Omi-Sugihara,M., Cha,M., Chen,C., Cavalcante,R.C.,
            Pan,H., Mishina,Y. and Ueharu,H.
  TITLE     Augmented Bone Morphogenetic Protein Signaling During TMJ
            Development Alters Morphology in a Timepoint-Dependent Manner
  JOURNAL   Int J Mol Sci 26 (4), 1655 (2025)
   PUBMED   40004119
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 128)
  AUTHORS   Dryhurst,D., Ishibashi,T., Rose,K.L., Eirin-Lopez,J.M.,
            McDonald,D., Silva-Moreno,B., Veldhoen,N., Helbing,C.C.,
            Hendzel,M.J., Shabanowitz,J., Hunt,D.F. and Ausio,J.
  TITLE     Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in
            vertebrates
  JOURNAL   BMC Biol 7, 86 (2009)
   PUBMED   20003410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 128)
  AUTHORS   Brault,V., Moore,R., Kutsch,S., Ishibashi,M., Rowitch,D.H.,
            McMahon,A.P., Sommer,L., Boussadia,O. and Kemler,R.
  TITLE     Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion
            results in dramatic brain malformation and failure of craniofacial
            development
  JOURNAL   Development 128 (8), 1253-1264 (2001)
   PUBMED   11262227
REFERENCE   8  (residues 1 to 128)
  AUTHORS   Chai,Y., Jiang,X., Ito,Y., Bringas,P. Jr., Han,J., Rowitch,D.H.,
            Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cranial neural crest during tooth and
            mandibular morphogenesis
  JOURNAL   Development 127 (8), 1671-1679 (2000)
   PUBMED   10725243
REFERENCE   9  (residues 1 to 128)
  AUTHORS   Jiang,X., Rowitch,D.H., Soriano,P., McMahon,A.P. and Sucov,H.M.
  TITLE     Fate of the mammalian cardiac neural crest
  JOURNAL   Development 127 (8), 1607-1616 (2000)
   PUBMED   10725237
REFERENCE   10 (residues 1 to 128)
  AUTHORS   Danielian,P.S., Muccino,D., Rowitch,D.H., Michael,S.K. and
            McMahon,A.P.
  TITLE     Modification of gene activity in mouse embryos in utero by a
            tamoxifen-inducible form of Cre recombinase
  JOURNAL   Curr Biol 8 (24), 1323-1326 (1998)
   PUBMED   9843687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ069840.1, BC147294.1 and
            AL646020.15.
            
            On or before Aug 29, 2009 this sequence version replaced
            XP_912773.1, XP_001476118.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ069840.1, FO713747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression
            replication-independent histone :: PMID: 20003410
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.01 cM"
     Protein         1..128
                     /product="histone H2A.V isoform 1"
                     /note="histone H2A.F/Z; histone H2A.V; H2A histone family,
                     member V; H2A.Z variant histone 2"
                     /calculated_mol_wt=13378
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3THW5.3)"
     Site            5
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:16204459; propagated from
                     UniProtKB/Swiss-Prot (Q3THW5.3)"
     Region          6..121
                     /region_name="PLN00154"
                     /note="histone H2A; Provisional"
                     /db_xref="CDD:177756"
     Site            8
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:16204459; propagated from
                     UniProtKB/Swiss-Prot (Q3THW5.3)"
     Site            12
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:16204459; propagated from
                     UniProtKB/Swiss-Prot (Q3THW5.3)"
     CDS             1..128
                     /gene="H2az2"
                     /gene_synonym="C530002L11Rik; H2a.z-2; H2A.Z2; H2afv;
                     H2av; Tg(Wnt1-cre)11Rth; Wnt1-Cre; Wnt1::Cre; Wnt1cre"
                     /coded_by="NM_029938.1:105..491"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48750.1"
                     /db_xref="GeneID:77605"
                     /db_xref="MGI:MGI:1924855"
ORIGIN      
        1 maggkagkds gkakakavsr sqraglqfpv grihrhlktr ttshgrvgat aavysaaile
       61 yltaevlela gnaskdlkvk ritprhlqla irgdeeldsl ikatiagggv iphihkslig
      121 kkgqqkta
//
LOCUS       NP_001400281             752 aa            linear   ROD 27-AUG-2025
DEFINITION  short transient receptor potential channel 1 isoform 4 [Mus
            musculus].
ACCESSION   NP_001400281
VERSION     NP_001400281.1
DBSOURCE    REFSEQ: accession NM_001413352.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 752)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 752)
  AUTHORS   Ray,S., McCall,J.L., Tian,J.B., Jeon,J., Douglas,A., Tyler,K.,
            Liu,S., Berry,K., Nicewarner,B., Hall,C., Groschner,K., Bacsa,B.,
            Geldenhuys,W., Zhu,M.X., Blair,H.C., Barnett,J.B. and Soboloff,J.
  TITLE     Targeting TRPC channels for control of arthritis-induced bone
            erosion
  JOURNAL   Sci Adv 11 (3), eabm9843 (2025)
   PUBMED   39813349
REFERENCE   3  (residues 1 to 752)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   4  (residues 1 to 752)
  AUTHORS   Atkins,R.M., Pantalia,M., Skaggs,C., Lau,A.K., Mahmood,M.B.,
            Anwar,M.M., Barron,L., Eby,B., Khan,U., Tsiokas,L. and Lau,K.
  TITLE     Normotensive metabolic syndrome in Transient Receptor Potential
            Canonical Channel type 1 Trpc1-/- mice
  JOURNAL   Biol Open 13 (7) (2024)
   PUBMED   38885005
  REMARK    GeneRIF: Normotensive metabolic syndrome in Transient Receptor
            Potential Canonical Channel type 1 Trpc1-/- mice.
REFERENCE   5  (residues 1 to 752)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 752)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
REFERENCE   7  (residues 1 to 752)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (residues 1 to 752)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (residues 1 to 752)
  AUTHORS   Sakura,H. and Ashcroft,F.M.
  TITLE     Identification of four trp1 gene variants murine pancreatic
            beta-cells
  JOURNAL   Diabetologia 40 (5), 528-532 (1997)
   PUBMED   9165220
REFERENCE   10 (residues 1 to 752)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC157947.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.1654378.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.2 cM"
     Protein         1..752
                     /product="short transient receptor potential channel 1
                     isoform 4"
                     /note="short transient receptor potential channel 1;
                     trp-related protein 1; transient receptor protein 1"
                     /calculated_mol_wt=86523
     Region          48..733
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     Site            order(53,56..58,60..61,65,68,81,83,85,89..90,93..95,
                     97..98,102,105,117,119,121,130..131,134..136,138..139,143,
                     146)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          83..117
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          119..149
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..752
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /coded_by="NM_001413352.1:510..2768"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
ORIGIN      
        1 mmaalypstd lsgvsssslp sspsssspne vmalkdvrev keentlnekl fllacdkgdy
       61 ymvkkileen ssgdlnincv dvlgrnavti tienesldil qllldygcqk lmeriqnpey
      121 sttmdvapvi laahrnnyei ltmllkqdvs lpkphavgce ctlcsaknkk dslrhsrcla
      181 spalimltee dpilrafels adlkelslve vefrndyeel arqckmfakd llaqarnsre
      241 levilnhtss depldkrgll eermnlsrlk laikynqkef vsqsncqqfl ntvwfgqmsg
      301 yrrkptckki mtvltvgifw pvlslcylia pksqfgriih tpfmkfiihg asyftfllll
      361 nlyslvyned kkntmgpale ridyllilwi igmiwsdikr lwyegledfl eesrnqlsfv
      421 mnslylatfa lkvvahnkfh dfadrkdwda fhptlvaegl fafanvlsyl rlffmyttss
      481 ilgplqismg qmlqdfgkfl gmfllvlfsf tigltqlydk gytskeqkdc vgifceqqsn
      541 dtfhsfigtc falfwyifsl ahvaifvtrf sygeelqsfv gavivgtynv vvvivltkll
      601 vamlhksfql ianhedkewk faraklwlsy fddkctlppp fniipspkti cymisslskw
      661 icshtskgkv krqnslkewr nlkqkrdeny qkvmcclvhr yltsmrqkmq stdqatvenl
      721 nelrqdlskf rneirdllgf rtskyamfyp rn
//
LOCUS       NP_032398                459 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-7 receptor subunit alpha isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_032398
VERSION     NP_032398.3
DBSOURCE    REFSEQ: accession NM_008372.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Philips,R.L., Liao,Y.C., Lau,C.M., Morrison,T.A., Jiang,K.,
            Hutchinson,A., Shayne,J., Yao,C., Sun,J.C., Hickman,H.D.,
            Milner,J.D., Holland,S., Kanno,Y., Lionakis,M.S. and O'Shea,J.J.
  TITLE     An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte
            programs during viral infection
  JOURNAL   Sci Immunol 10 (107), eado5986 (2025)
   PUBMED   40446018
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Naef,P., Jaeger-Ruckstuhl,C.A., Schnuriger,N., Forster,S.,
            Monteiro,I., Brigger,D., Eggel,A., Kessenbrock,K., Riether,C. and
            Ochsenbein,A.F.
  TITLE     IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing
            of HSCs in response to hematopoietic stress and aging
  JOURNAL   iScience 28 (5), 112378 (2025)
   PUBMED   40384929
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Abe,S., Kagao,M., Asahi,T., Kato,R., Tani-Ichi,S., Shimba,A.,
            Ishibashi,R., Miyachi,H., Kitano,S., Miyazaki,M., Rodewald,H.R.,
            Toyoshima,F. and Ikuta,K.
  TITLE     The transcription factor RORalpha is required for the development
            of type 1 innate lymphoid cells in adult bone marrow
  JOURNAL   J Immunol 214 (4), 575-581 (2025)
   PUBMED   40079843
REFERENCE   4  (residues 1 to 459)
  AUTHORS   Jarjour,N.N., Dalzell,T.S., Maurice,N.J., Wanhainen,K.M., Peng,C.,
            O'Flanagan,S.D., DePauw,T.A., Block,K.E., Valente,W.J., Ashby,K.M.,
            Masopust,D. and Jameson,S.C.
  TITLE     Collaboration between interleukin-7 and -15 enables adaptation of
            tissue-resident and circulating memory CD8+ T cells to cytokine
            deficiency
  JOURNAL   Immunity 58 (3), 616-631 (2025)
   PUBMED   40023156
REFERENCE   5  (residues 1 to 459)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   6  (residues 1 to 459)
  AUTHORS   He,Y.W., Adkins,B., Furse,R.K. and Malek,T.R.
  TITLE     Expression and function of the gamma c subunit of the IL-2, IL-4,
            and IL-7 receptors. Distinct interaction of gamma c in the IL-4
            receptor
  JOURNAL   J Immunol 154 (4), 1596-1605 (1995)
   PUBMED   7530740
REFERENCE   7  (residues 1 to 459)
  AUTHORS   Venkitaraman,A.R. and Cowling,R.J.
  TITLE     Interleukin-7 induces the association of phosphatidylinositol
            3-kinase with the alpha chain of the interleukin-7 receptor
  JOURNAL   Eur J Immunol 24 (9), 2168-2174 (1994)
   PUBMED   7522165
REFERENCE   8  (residues 1 to 459)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   9  (residues 1 to 459)
  AUTHORS   Pleiman,C.M., Gimpel,S.D., Park,L.S., Harada,H., Taniguchi,T. and
            Ziegler,S.F.
  TITLE     Organization of the murine and human interleukin-7 receptor genes:
            two mRNAs generated by differential splicing and presence of a type
            I-interferon-inducible promoter
  JOURNAL   Mol Cell Biol 11 (6), 3052-3059 (1991)
   PUBMED   2038316
REFERENCE   10 (residues 1 to 459)
  AUTHORS   Goodwin,R.G., Friend,D., Ziegler,S.F., Jerzy,R., Falk,B.A.,
            Gimpel,S., Cosman,D., Dower,S.K., March,C.J., Namen,A.E. et al.
  TITLE     Cloning of the human and murine interleukin-7 receptors:
            demonstration of a soluble form and homology to a new receptor
            superfamily
  JOURNAL   Cell 60 (6), 941-951 (1990)
   PUBMED   2317865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY776757.1, AK040364.1, AK042264.1 and BC089571.1.
            
            On Mar 9, 2004 this sequence version replaced NP_032398.2.
            
            Summary: Interleukin-7 is a glycoptorein involved in the regulation
            of lymphopoiesis. Response of cells to IL7 is dependent on the
            presence of the interleukin 7 receptor (IL7R); the active receptor
            is a alpha/gamma chain heterodimer. The gamma(c) chain, which also
            associates with the interleukin-2 receptor, serves primarily to
            activate signal transduction by the IL7R complex, while the alpha
            chain of IL7R determines specific signaling events through its
            association with cytoplasmic signaling molecules. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 4.16 cM"
     Protein         1..459
                     /product="interleukin-7 receptor subunit alpha isoform 1
                     precursor"
                     /note="IL-7 receptor alpha chain; interleukin-7 receptor
                     subunit alpha; IL-7RA; IL-7R-alpha; IL-7R subunit alpha;
                     IL-7 receptor subunit alpha; interleukin 7 receptor alpha
                     chain"
                     /calculated_mol_wt=49525
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2099
     mat_peptide     21..459
                     /product="Interleukin-7 receptor subunit alpha.
                     /id=PRO_0000010910"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
                     /calculated_mol_wt=49525
     Region          32..127
                     /region_name="FN3_7"
                     /note="Fibronectin type III domain; pfam18447"
                     /db_xref="CDD:465772"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16872.2)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16872.2)"
     Region          131..219
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            177
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P16872.2)"
     Region          218..222
                     /region_name="WSXWS motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
     Site            order(218..219,221..222)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            240..264
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
     Region          272..280
                     /region_name="Box 1 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P16872.2)"
     Region          337..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
     Region          378..413
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P16872.2)"
     CDS             1..459
                     /gene="Il7r"
                     /gene_synonym="CD127; IL-7Ralpha"
                     /coded_by="NM_008372.4:135..1514"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS27376.1"
                     /db_xref="GeneID:16197"
                     /db_xref="MGI:MGI:96562"
ORIGIN      
        1 mmalgrafai vfcliqavsg esgnaqdgdl edadaddhsf wchsqlevdg sqhlltcafn
       61 dsdintanle fqicgallrv kcltlnklqd iyfiktsefl ligssnicvk lgqknltckn
      121 maintivkae apsdlkvvyr keandflvtf naphlkkkyl kkvkhdvayr pargesnwth
      181 vslfhtrtti pqrklrpkam yeikvrsiph ndyfkgfwse wspsstfetp epknqggwdp
      241 vlpsvtilsl fsvfllvila hvlwkkrikp vvwpslpdhk ktleqlckkp ktslnvsfnp
      301 esfldcqihe vkgveardev esflpndlpa qpeeletqgh raavhsanrs petsvsppet
      361 vrresplrcl arnlstcnap pllssrspdy rdgdrnrppv yqdllpnsgn tnvpvpvpqp
      421 lpfqsgilip vsqrqpists svlnqeeayv tmssfyqnk
//
LOCUS       NP_035188               1089 aa            linear   ROD 27-AUG-2025
DEFINITION  platelet-derived growth factor receptor alpha isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_035188
VERSION     NP_035188.2
DBSOURCE    REFSEQ: accession NM_011058.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1089)
  AUTHORS   Tran,L.N., Shinde,A., Schuster,K.H., Sabaawy,A., Dale,E.,
            Welch,M.J., Isner,T.J., Nunez,S.A., Garcia-Moreno,F.,
            Sagerstrom,C.G., Appel,B.H. and Franco,S.J.
  TITLE     Epigenetic priming of neural progenitors by Notch enhances Sonic
            hedgehog signaling and establishes gliogenic competence
  JOURNAL   Genes Dev 39 (13-14), 886-906 (2025)
   PUBMED   40404401
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1089)
  AUTHORS   Summers,B.S., Blizzard,C.A., Ricci,R.R., Pitman,K.A., Dempsey,B.,
            McMullan,S., Sutherland,B.A., Young,K.M. and Cullen,C.L.
  TITLE     Demyelination Produces a Shift in the Population of Cortical
            Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40345851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1089)
  AUTHORS   Van Hove,H., Gluck,C., Mildenberger,W., Petrova,E., Maheshwari,U.,
            Hane,P., Kreiner,V., Bijnen,M., Mussak,C., Utz,S.G., Droux,J.,
            Ingelfinger,F., Ashworth,C., Stifter,S.A., Roussel,E., Lelios,I.,
            Vermeer,M., Huang,S.F., Zhou,Q., Chen,Z., Calvet,C., Bourgeois,S.,
            Schaffenrath,J., Razansky,D., Juang,J.X., Asano,K., Pelczar,P.,
            Mundt,S., Weber,B., Wegener,S., Tugues,S., Stockmann,C., Becher,B.,
            Keller,A., El Amki,M. and Greter,M.
  TITLE     Interleukin-34-dependent perivascular macrophages promote vascular
            function in the brain
  JOURNAL   Immunity 58 (5), 1289-1305 (2025)
   PUBMED   40315842
REFERENCE   4  (residues 1 to 1089)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1089)
  AUTHORS   Mueller,A.A., van Velthoven,C.T., Fukumoto,K.D., Cheung,T.H. and
            Rando,T.A.
  TITLE     Intronic polyadenylation of PDGFRalpha in resident stem cells
            attenuates muscle fibrosis
  JOURNAL   Nature 540 (7632), 276-279 (2016)
   PUBMED   27894125
  REMARK    GeneRIF: polyadenylation of a PDGFRalpha intron in resident stem
            cells attenuates muscle fibrosis
REFERENCE   6  (residues 1 to 1089)
  AUTHORS   Demoulin,J.B. and Essaghir,A.
  TITLE     PDGF receptor signaling networks in normal and cancer cells
  JOURNAL   Cytokine Growth Factor Rev 25 (3), 273-283 (2014)
   PUBMED   24703957
  REMARK    Review article
REFERENCE   7  (residues 1 to 1089)
  AUTHORS   Palmieri,S.L., Payne,J., Stiles,C.D., Biggers,J.D. and Mercola,M.
  TITLE     Expression of mouse PDGF-A and PDGF alpha-receptor genes during
            pre- and post-implantation development: evidence for a
            developmental shift from an autocrine to a paracrine mode of action
  JOURNAL   Mech Dev 39 (3), 181-191 (1992)
   PUBMED   1292572
REFERENCE   8  (residues 1 to 1089)
  AUTHORS   Do,M.S., Fitzer-Attas,C., Gubbay,J., Greenfeld,L., Feldman,M. and
            Eisenbach,L.
  TITLE     Mouse platelet-derived growth factor alpha receptor: sequence,
            tissue-specific expression and correlation with metastatic
            phenotype
  JOURNAL   Oncogene 7 (8), 1567-1575 (1992)
   PUBMED   1321404
REFERENCE   9  (residues 1 to 1089)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   10 (residues 1 to 1089)
  AUTHORS   Truslove,G.M.
  TITLE     A new allele at the patch locus in the mouse
  JOURNAL   Genet Res 29 (2), 183-186 (1977)
   PUBMED   863250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120348.9, AK147267.1,
            BY628767.1 and CK627326.1.
            
            On Mar 23, 2007 this sequence version replaced NP_035188.1.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins. Binding of platelet-derived growth factor
            protein ligands to this receptor triggers receptor dimerization and
            autophosphorylation, resulting in the activation of several
            downstream signaling pathways. Signaling through the encoded
            receptor plays a role in gastrulation and the development of nearly
            all organ systems. Mice lacking a functional copy of this gene
            reportedly exhibit defects in lung, skeleton, testis and the
            central nervous system, and die soon after birth. Alternative
            splicing and intronic polyadenylation of gene transcripts have been
            implicated in muscle regeneration and fibrosis in adult mice.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147267.1, M84607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     Protein         1..1089
                     /product="platelet-derived growth factor receptor alpha
                     isoform 1 precursor"
                     /EC_number="2.7.10.1"
                     /note="alpha-type platelet-derived growth factor receptor;
                     platelet-derived growth factor receptor alpha;
                     PDGF-R-alpha; CD140 antigen-like family member A; PDGF
                     alpha chain; Alpha platelet-derived growth factor receptor
                     precursor (PDGF-R-alpha); PDGFR-alpha"
                     /calculated_mol_wt=120197
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
                     /calculated_mol_wt=2505
     mat_peptide     25..1089
                     /product="Platelet-derived growth factor receptor alpha.
                     /id=PRO_0000016761"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
                     /calculated_mol_wt=120197
     Region          28..100
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            76
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            103
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Region          212..310
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          231..235
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          244..248
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          273..277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          302..305
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          313..413
                     /region_name="Ig4_PDGFR"
                     /note="Fourth immunoglobulin (Ig)-like domain of
                     platelet-derived growth factor receptor (PDGFR); cd05859"
                     /db_xref="CDD:409445"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            359
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            458
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            468
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            506
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            529..549
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Region          555..956
                     /region_name="PTKc_PDGFR_alpha"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Platelet Derived Growth Factor Receptor alpha; cd05105"
                     /db_xref="CDD:173653"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            574
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            order(599..600,602..605,607,625,627,675,677,681,818,
                     822..823,825,836,854..858,867,902)
                     /site_type="active"
                     /db_xref="CDD:173653"
     Site            order(599..600,602..605,607,625,627,675,677,681,822..823,
                     825,836)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173653"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234, ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Site            731
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            754
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            762
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            768
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            order(818,822,854..858,867,902)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173653"
     Site            835..860
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173653"
     Site            849
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            988
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Region          1018..1089
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Site            1018
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     CDS             1..1089
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /coded_by="NM_011058.3:220..3489"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS19351.1"
                     /db_xref="GeneID:18595"
                     /db_xref="MGI:MGI:97530"
ORIGIN      
        1 mgtshqvflv lsclltgpgl iscqlllpsi lpnenekivq lnssfslrcv gesevswqhp
       61 mseeddpnve irseennsgl fvtvlevvna saahtgwytc yynhtqtdes eiegrhiyiy
      121 vpdpdmafvp lgmtdslviv eeddsaiipc rttdpetqvt lhnngrlvpa sydsrqgfng
      181 tfsvgpyice atvkgrtfkt sefnvyalka tselnlemda rqtvykaget ivvtcavfnn
      241 evvdlqwtyp gevrnkgitm leeiklpsik lvytltvpka tvkdsgeyec aarqatkevk
      301 emkrvtisvh ekgfveiept fgqleavnlh evrefvvevq ayptpriswl kdnltlienl
      361 teittdvqks qetryqsklk lirakeedsg hytiivqned dvksytfels tlvpasildl
      421 vddhhgsggg qtvrctaegt plpeidwmic khikkcnndt swtvlasnvs niitelprrg
      481 rstvegrvsf akveetiavr claknnlsvv arelklvapt lrseltvaaa vlvllviviv
      541 slivlvviwk qkpryeirwr viesispdgh eyiyvdpmql pydsrwefpr dglvlgrilg
      601 sgafgkvveg tayglsrsqp vmkvavkmlk ptarssekqa lmselkimth lgphlnivnl
      661 lgactksgpi yiiteycfyg dlvnylhknr dsfmsqhpek pkkdldifgl npadestrsy
      721 vilsfenngd ymdmkqadtt qyvpmlerke vskysdiqrs lydrpasykk ksmldsevkn
      781 llsdddsegl tlldllsfty qvargmefla skncvhrdla arnvllaqgk ivkicdfgla
      841 rdimhdsnyv skgstflpvk wmapesifdn lyttlsdvws ygillweifs lggtpypgmm
      901 vdstfynkik sgyrmakpdh atsevyeimv qcwnsepekr psfyhlseiv enllpgqykk
      961 syekihldfl ksdhpavarm rvdsdnayig vtykneedkl kdweggldeq rlsadsgyii
     1021 plpdidpvpe eedlgkrnrh ssqtseesai etgsssstfi kredetiedi dmmddigids
     1081 sdlvedsfl
//
LOCUS       NP_035746                260 aa            linear   ROD 27-AUG-2025
DEFINITION  CD40 ligand [Mus musculus].
ACCESSION   NP_035746
VERSION     NP_035746.2
DBSOURCE    REFSEQ: accession NM_011616.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 260)
  AUTHORS   Schiele,P., Japp,A.S., Stark,R., Sattelberg,J.J., Nikolaou,C.,
            Kornhuber,G., Abbasi,P., Ding,N., Rosnev,S., Meinke,S., Muhle,K.,
            Loyal,L., Braun,J., Dingeldey,M., Durlanik,S., Matzmohr,N.,
            Ponikwicka-Tyszko,D., Wolczynski,S., Rahman,N.A., Taniuchi,I.,
            Schlickeiser,S., Giesecke-Thiel,C., Blankenstein,T., Na,I.K.,
            Thiel,A. and Frentsch,M.
  TITLE     CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in
            CD40-expressing cancer cells
  JOURNAL   Sci Adv 11 (21), eadr9331 (2025)
   PUBMED   40397730
REFERENCE   2  (residues 1 to 260)
  AUTHORS   Campos Canesso,M.C., de Castro,T.B.R., Nakandakari-Higa,S.,
            Lockhart,A., Luehr,J., Bortolatto,J., Parsa,R., Esterhazy,D.,
            Lyu,M., Liu,T.T., Murphy,K.M., Sonnenberg,G.F., Reis,B.S.,
            Victora,G.D. and Mucida,D.
  TITLE     Identification of antigen-presenting cell-T cell interactions
            driving immune responses to food
  JOURNAL   Science 387 (6739), eado5088 (2025)
   PUBMED   39700315
REFERENCE   3  (residues 1 to 260)
  AUTHORS   Gribonika,I., Band,V.I., Chi,L., Perez-Chaparro,P.J., Link,V.M.,
            Ansaldo,E., Oguz,C., Bousbaine,D., Fischbach,M.A. and Belkaid,Y.
  TITLE     Skin autonomous antibody production regulates host-microbiota
            interactions
  JOURNAL   Nature 638 (8052), 1043-1053 (2025)
   PUBMED   39662506
  REMARK    Erratum:[Nature. 2025 Mar;639(8053):E6. doi:
            10.1038/s41586-025-08776-8. PMID: 39972149]
REFERENCE   4  (residues 1 to 260)
  AUTHORS   Chudnovskiy,A., Castro,T.B.R., Nakandakari-Higa,S., Cui,A.,
            Lin,C.H., Sade-Feldman,M., Phillips,B.K., Pae,J., Mesin,L.,
            Bortolatto,J., Schweitzer,L.D., Pasqual,G., Lu,L.F., Hacohen,N. and
            Victora,G.D.
  TITLE     Proximity-dependent labeling identifies dendritic cells that drive
            the tumor-specific CD4+ T cell response
  JOURNAL   Sci Immunol 9 (100), eadq8843 (2024)
   PUBMED   39365874
REFERENCE   5  (residues 1 to 260)
  AUTHORS   Etesami,N.S., Barker,K.A., Shenoy,A.T., De Ana,C.L., Arafa,E.I.,
            Grifno,G.N., Matschulat,A.M., Vannini,M.E., Pihl,R.M.F.,
            Breen,M.P., Soucy,A.M., Goltry,W.N., Ha,C.T., Betsuyaku,H.,
            Browning,J.L., Varelas,X., Traber,K.E., Jones,M.R., Quinton,L.J.,
            Maglione,P.J., Nia,H.T., Belkina,A.C. and Mizgerd,J.P.
  TITLE     B cells in the pneumococcus-infected lung are heterogeneous and
            require CD4+ T cell help including CD40L to become resident memory
            B cells
  JOURNAL   Front Immunol 15, 1382638 (2024)
   PUBMED   38715601
  REMARK    GeneRIF: B cells in the pneumococcus-infected lung are
            heterogeneous and require CD4[+] T cell help including CD40L to
            become resident memory B cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 260)
  AUTHORS   Covey,L.R., Cleary,A.M., Yellin,M.J., Ware,R., Sullivan,G.,
            Belko,J., Parker,M., Rothman,P., Chess,L. and Lederman,S.
  TITLE     Isolation of cDNAs encoding T-BAM, a surface glycoprotein on CD4+ T
            cells mediating contact-dependent helper function for B cells:
            identity with the CD40-ligand
  JOURNAL   Mol Immunol 31 (6), 471-484 (1994)
   PUBMED   7514269
REFERENCE   7  (residues 1 to 260)
  AUTHORS   Hasbold,J. and Klaus,G.G.
  TITLE     B cells from CBA/N mice do not proliferate following ligation of
            CD40
  JOURNAL   Eur J Immunol 24 (1), 152-157 (1994)
   PUBMED   7517360
REFERENCE   8  (residues 1 to 260)
  AUTHORS   Kennedy,M.K., Mohler,K.M., Shanebeck,K.D., Baum,P.R., Picha,K.S.,
            Otten-Evans,C.A., Janeway,C.A. Jr. and Grabstein,K.H.
  TITLE     Induction of B cell costimulatory function by recombinant murine
            CD40 ligand
  JOURNAL   Eur J Immunol 24 (1), 116-123 (1994)
   PUBMED   7517359
REFERENCE   9  (residues 1 to 260)
  AUTHORS   Farrah,T. and Smith,C.A.
  TITLE     Emerging cytokine family
  JOURNAL   Nature 358 (6381), 26 (1992)
   PUBMED   1377364
REFERENCE   10 (residues 1 to 260)
  AUTHORS   Armitage,R.J., Fanslow,W.C., Strockbine,L., Sato,T.A.,
            Clifford,K.N., Macduff,B.M., Anderson,D.M., Gimpel,S.D.,
            Davis-Smith,T., Maliszewski,C.R. et al.
  TITLE     Molecular and biological characterization of a murine ligand for
            CD40
  JOURNAL   Nature 357 (6373), 80-82 (1992)
   PUBMED   1374165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672128.8.
            
            On Jul 25, 2001 this sequence version replaced NP_035746.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X65453.2, BC119225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 31.21 cM"
     Protein         1..260
                     /product="CD40 ligand"
                     /note="T-cell antigen Gp39; TNF-related activation
                     protein; tumor necrosis factor ligand superfamily member
                     5; tumor necrosis factor ligand 8b"
                     /calculated_mol_wt=29239
     Site            23..46
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P27548.2)"
     Site            111..112
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P27548.2)"
     mat_peptide     112..260
                     /product="CD40 ligand, soluble form.
                     /evidence=ECO:0000250|UniProtKB:P29965.
                     /id=PRO_0000034491"
                     /note="propagated from UniProtKB/Swiss-Prot (P27548.2)"
                     /calculated_mol_wt=16410
     Site            order(124,169,171,223,228,254,258)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Region          137..260
                     /region_name="TNF"
                     /note="TNF(Tumour Necrosis Factor) family; pfam00229"
                     /db_xref="CDD:425540"
     Site            order(140..141,146,189,196,200)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     Site            239
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P27548.2)"
     CDS             1..260
                     /gene="Cd40lg"
                     /gene_synonym="CD154; CD40-L; Cd40l; gp39; HIGM1; IGM;
                     IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP"
                     /coded_by="NM_011616.3:68..850"
                     /db_xref="CCDS:CCDS30152.1"
                     /db_xref="GeneID:21947"
                     /db_xref="MGI:MGI:88337"
ORIGIN      
        1 mietysqpsp rsvatglpas mkifmylltv flitqmigsv lfavylhrrl dkveeevnlh
       61 edfvfikklk rcnkgegsls llnceemrrq fedlvkditl nkeekkensf emqrgdedpq
      121 iaahvvsean snaasvlqwa kkgyytmksn lvmlengkql tvkreglyyv ytqvtfcsnr
      181 epssqrpfiv glwlkpssgs erillkaant hsssqlceqq svhlggvfel qagasvfvnv
      241 teasqvihrv gfssfgllkl
//
LOCUS       NP_001120735             393 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor protein 63 isoform g [Mus musculus].
ACCESSION   NP_001120735
VERSION     NP_001120735.1
DBSOURCE    REFSEQ: accession NM_001127263.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 393)
  AUTHORS   Guo,J., Li,N., Liu,Q., Hao,Z., Zhu,G., Wang,X., Wang,H., Pan,Q.,
            Xu,B., Han,Y., Zhang,G., Lian,Y., Zhang,W., Gu,Y., Lin,N., Zeng,X.,
            Jin,Z., Lan,W., Jiang,J., Gao,D., Dong,L., Yuan,H., Liang,C. and
            Qin,J.
  TITLE     KMT2C deficiency drives transdifferentiation of double-negative
            prostate cancer and confer resistance to AR-targeted therapy
  JOURNAL   Cancer Cell 43 (7), 1261-1278 (2025)
   PUBMED   40280125
REFERENCE   2  (residues 1 to 393)
  AUTHORS   Kooistra,T., Saez,B., Roche,M., Egea-Zorrilla,A., Li,D.,
            Anketell,D., Nguyen,N., Villoria,J., Gillis,J., Petri,E., Vera,L.,
            Blasco-Iturri,Z., Smith,N.P., Alladina,J., Zhang,Y., Vinarsky,V.,
            Shivaraju,M., Sheng,S.L., Chen,M., Gonzalez-Celeiro,M., Mou,H.,
            Waghray,A., Lin,B., Paksa,A., Yanger,K., Tata,P.R., Zhao,R.,
            Causton,B., Zulueta,J.J., Prosper,F., Cho,J.L., Villani,A.C.,
            Haber,A., Rajagopal,J., Medoff,B.D. and Pardo-Saganta,A.
  TITLE     Airway basal stem cells are necessary for the maintenance of
            functional intraepithelial airway macrophages
  JOURNAL   Cell Rep 44 (6), 115860 (2025)
   PUBMED   40512621
REFERENCE   3  (residues 1 to 393)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   4  (residues 1 to 393)
  AUTHORS   Chen,X., Sun,W., Kong,X., Ming,X., Zhang,Y., Yan,W., Mohibi,S.,
            Chen,M., Mitchell,K. and Zhang,J.
  TITLE     TAp63gamma is the primary isoform of TP63 for tumor suppression but
            not development
  JOURNAL   Cell Death Discov 11 (1), 51 (2025)
   PUBMED   39915463
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 393)
  AUTHORS   Mills,A.A., Zheng,B., Wang,X.J., Vogel,H., Roop,D.R. and Bradley,A.
  TITLE     p63 is a p53 homologue required for limb and epidermal
            morphogenesis
  JOURNAL   Nature 398 (6729), 708-713 (1999)
   PUBMED   10227293
REFERENCE   6  (residues 1 to 393)
  AUTHORS   Kaelin,W.G. Jr.
  TITLE     The emerging p53 gene family
  JOURNAL   J Natl Cancer Inst 91 (7), 594-598 (1999)
   PUBMED   10203277
  REMARK    Review article
REFERENCE   7  (residues 1 to 393)
  AUTHORS   Augustin,M., Bamberger,C., Paul,D. and Schmale,H.
  TITLE     Cloning and chromosomal mapping of the human p53-related KET gene
            to chromosome 3q27 and its murine homolog Ket to mouse chromosome
            16
  JOURNAL   Mamm Genome 9 (11), 899-902 (1998)
   PUBMED   9799841
REFERENCE   8  (residues 1 to 393)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (residues 1 to 393)
  AUTHORS   Senoo,M., Seki,N., Ohira,M., Sugano,S., Watanabe,M., Inuzuka,S.,
            Okamoto,T., Tachibana,M., Tanaka,T., Shinkai,Y. and Kato,H.
  TITLE     A second p53-related protein, p73L, with high homology to p73
  JOURNAL   Biochem Biophys Res Commun 248 (3), 603-607 (1998)
   PUBMED   9703973
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
REFERENCE   10 (residues 1 to 393)
  AUTHORS   Schmale,H. and Bamberger,C.
  TITLE     A novel protein with strong homology to the tumor suppressor p53
  JOURNAL   Oncogene 15 (11), 1363-1367 (1997)
   PUBMED   9315105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC092537.1 and AK140023.1.
            
            Summary: This gene encodes tumor protein p63, a member of the p53
            family of transcription factors involved in cellular responses to
            stress and development. The family members include tumor proteins
            p53, p63, and p73, which have high sequence similarity to one
            another. This similarity allows p63 and p73 to transactivate
            p53-responsive genes causing cell cycle arrest and apoptosis. The
            family members can interact with each other in many ways, including
            direct and indirect protein interactions. This results in mutual
            regulation of target gene promoters. Tumor protein p63 -/- mice
            have several developmental defects which include the lack of limbs
            and other tissues, such as teeth and mammary glands, which develop
            as a result of interactions between mesenchyme and epithelium. Both
            alternative splicing and the use of alternative promoters result in
            multiple transcript variants encoding different protein
            isoforms.[provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (7) is an alternate promoter
            product; it lacks several 5' and 3' exons, but has alternate 5' and
            3' exons, as compared to variant 1. The resulting isoform (g, also
            known as DNp63gamma) has shorter and different N- and C-termini, as
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 17.37 cM"
     Protein         1..393
                     /product="tumor protein 63 isoform g"
                     /note="tumor protein 63"
                     /calculated_mol_wt=44308
     Region          83..264
                     /region_name="P53"
                     /note="P53 DNA-binding domain; cd08367"
                     /db_xref="CDD:176262"
     Site            order(150,153,214,218)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:176262"
     Site            order(151..153,155)
                     /site_type="other"
                     /note="dimerization site [polypeptide binding]"
                     /db_xref="CDD:176262"
     Site            order(215,217,224,249,251..253,256)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     Region          297..337
                     /region_name="P53_tetramer"
                     /note="P53 tetramerization motif; pfam07710"
                     /db_xref="CDD:462238"
     CDS             1..393
                     /gene="Trp63"
                     /gene_synonym="Ket; P51/P63; P63; P73l; Tp63; Trp53rp1"
                     /coded_by="NM_001127263.1:145..1326"
                     /note="isoform g is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS49812.1"
                     /db_xref="GeneID:22061"
                     /db_xref="MGI:MGI:1330810"
ORIGIN      
        1 mlylennaqt qfsepqytnl gllnsmdqqi qngssstspy ntdhaqnsvt apspyaqpss
       61 tfdalspspa ipsntdypgp hsfdvsfqqs staksatwty stelkklycq iaktcpiqik
      121 vmtpppqgav irampvykka ehvtevvkrc pnhelsrefn egqiappshl irvegnshaq
      181 yvedpitgrq svlvpyeppq vgtefttvly nfmcnsscvg gmnrrpilii vtletrdgqv
      241 lgrrcfeari cacpgrdrka dedsirkqqv sdsakngdgt krpfrqnthg iqmtsikkrr
      301 spddellylp vrgretyeml lkikeslelm qylpqhtiet yrqqqqqqhq hllqkhllsa
      361 cfrnelvepr geaptqsdvf frhsnppnhs vyp
//
LOCUS       NP_001416489             525 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear factor 1 B-type isoform 7 [Mus musculus].
ACCESSION   NP_001416489
VERSION     NP_001416489.1
DBSOURCE    REFSEQ: accession NM_001429560.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   4  (residues 1 to 525)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 525)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 525)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 525)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (residues 1 to 525)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   9  (residues 1 to 525)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   10 (residues 1 to 525)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670769.3, AL592283.5, BX324149.4 and AL773518.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.4 cM"
     Protein         1..525
                     /product="nuclear factor 1 B-type isoform 7"
                     /note="nuclear factor 1 B-type; nuclear factor 1/B;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /calculated_mol_wt=58524
     Region          33..69
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          91..195
                     /region_name="MH1"
                     /note="MH1 domain; pfam03165"
                     /db_xref="CDD:460833"
     Region          231..520
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     CDS             1..525
                     /gene="Nfib"
                     /gene_synonym="6720429L07Rik; CTF; E030026I10Rik; NF-I/B;
                     NF1-B; NFI-B"
                     /coded_by="NM_001429560.1:140..1717"
                     /note="isoform 7 is encoded by transcript variant 7"
                     /db_xref="GeneID:18028"
                     /db_xref="MGI:MGI:103188"
ORIGIN      
        1 mkvadsrmag ktsdssikwq lcydmsartw wmdefhpfie allphvraia ytwfnlqark
       61 rkyfkkhekr mskdeeravk dellsekpei kqkwasrlla klrkdirqey redfvltvtg
      121 kkhpccvlsn pdqkgkirri dclrqadkvw rldlvmvilf kgiplestdg erlmksphct
      181 npalcvqphh itvsvkeldl flayyvqeqd sgqsgspshs dpaknppgyl edsfvksgvf
      241 nvselvrvsr tpitqgtgvn fpigeipsqp yyhdmnsgvn lqrslsspps skrpktisid
      301 enmepsptgd fypspnspaa gsrtwherdq dmsspttmkk pekplfssts pqdssprlst
      361 fpqhhhpgip gvahsvistr tppppsplpf ptqailppap ssyfshptir ypphlnpqdt
      421 lknyvpsydp sspqtsqpns sgqvvgkvpg hftpvlapsp hpsavrpvtl tmtdtkpitt
      481 stegeaaspt attytasgts qanryvglsp rdpsflhqqq swylg
//
LOCUS       NP_001347186             366 aa            linear   ROD 27-AUG-2025
DEFINITION  dickkopf-related protein 3 isoform a precursor [Mus musculus].
ACCESSION   NP_001347186
VERSION     NP_001347186.1
DBSOURCE    REFSEQ: accession NM_001360257.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Song,J., Chen,Y., Chen,Y., Qiu,M., Xiang,W., Ke,B. and Fang,X.
  TITLE     DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner
  JOURNAL   Ren Fail 46 (1), 2343817 (2024)
   PUBMED   38682264
  REMARK    GeneRIF: DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner.
REFERENCE   3  (residues 1 to 366)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 366)
  AUTHORS   Martin Flores,N., Podpolny,M., McLeod,F., Workman,I., Crawford,K.,
            Ivanov,D., Leonenko,G., Escott-Price,V. and Salinas,P.C.
  TITLE     Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model
  JOURNAL   Elife 12, 89453 (2024)
   PUBMED   38285009
  REMARK    GeneRIF: Downregulation of Dickkopf-3, a Wnt antagonist elevated in
            Alzheimer's disease, restores synapse integrity and memory in a
            disease mouse model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 366)
  AUTHORS   Ang,S.J., Stump,R.J., Lovicu,F.J. and McAvoy,J.W.
  TITLE     Spatial and temporal expression of Wnt and Dickkopf genes during
            murine lens development
  JOURNAL   Gene Expr Patterns 4 (3), 289-295 (2004)
   PUBMED   15053977
REFERENCE   7  (residues 1 to 366)
  AUTHORS   Stump,R.J., Ang,S., Chen,Y., von Bahr,T., Lovicu,F.J., Pinson,K.,
            de Iongh,R.U., Yamaguchi,T.P., Sassoon,D.A. and McAvoy,J.W.
  TITLE     A role for Wnt/beta-catenin signaling in lens epithelial
            differentiation
  JOURNAL   Dev Biol 259 (1), 48-61 (2003)
   PUBMED   12812787
REFERENCE   8  (residues 1 to 366)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (residues 1 to 366)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (residues 1 to 366)
  AUTHORS   Monaghan,A.P., Kioschis,P., Wu,W., Zuniga,A., Bock,D., Poustka,A.,
            Delius,H. and Niehrs,C.
  TITLE     Dickkopf genes are co-ordinately expressed in mesodermal lineages
  JOURNAL   Mech Dev 87 (1-2), 45-56 (1999)
   PUBMED   10495270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO707532.1 and AC122343.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN01164131 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 58.74 cM"
     Protein         1..366
                     /product="dickkopf-related protein 3 isoform a precursor"
                     /note="dickkopf-related protein 3; dickkopf-3; dickkopf
                     homolog 3"
                     /calculated_mol_wt=36225
     sig_peptide     1..39
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3917
     Region          58..213
                     /region_name="Dkk3_N_Cys1"
                     /note="N-terminus of Dickkopf-related protein 3; includes
                     the first cysteine-rich (Cys-1) domain; cd23014"
                     /db_xref="CDD:438008"
     Region          216..302
                     /region_name="Dkk3_Cys2"
                     /note="second cysteine-rich (Cys-2) domain of
                     Dickkopf-related protein 3; cd23274"
                     /db_xref="CDD:438000"
     CDS             1..366
                     /gene="Dkk3"
                     /gene_synonym="dkk-3; mDkk-3"
                     /coded_by="NM_001360257.1:57..1157"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:50781"
                     /db_xref="MGI:MGI:1354952"
ORIGIN      
        1 maksgfswlg ggqrgtnmqr lggillctll aaavptapap sptvtwtpae pgpalnypqe
       61 eatlnemfre veelmedtqh klrsaveeme aeeaaaktss evnlaslppn yhnetstetr
      121 vgnntvhvhq evhkitnnqs gqvvfsetvi tsvgdeegkr sheciidedc gptrycqfss
      181 fkytcqpcrd qqmlctrdse ccgdqlcawg hctqkatkgg ngticdnqrd cqpglccafq
      241 rgllfpvctp lpvegelchd ptsqlldlit welepegald rcpcasgllc qphshslvym
      301 ckpafvgshd hseesqlpre apdeyedvgf igevrqeled lerslaqema fegpapvesl
      361 ggeeei
//
LOCUS       NP_001276373             128 aa            linear   ROD 27-AUG-2025
DEFINITION  calcitonin gene-related peptide 1 isoform Cgrp preproprotein [Mus
            musculus].
ACCESSION   NP_001276373 XP_006507337
VERSION     NP_001276373.1
DBSOURCE    REFSEQ: accession NM_001289444.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 128)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 128)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 128)
  AUTHORS   Santiago,C., Siegrist,J., Africawala,N., Handler,A., Tasnim,A.,
            Anjum,R., Turecek,J., Lehnert,B.P., Renauld,S., Choi,J.,
            Nolan-Tamariz,M., Iskols,M., Magee,A.R., Paradis,S., Sharma,N. and
            Ginty,D.D.
  TITLE     Activity-dependent development of the body's touch receptors
  JOURNAL   Neuron 113 (11), 1758-1773 (2025)
   PUBMED   40381613
REFERENCE   4  (residues 1 to 128)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   5  (residues 1 to 128)
  AUTHORS   Zhi,X., Wu,F., Qian,J., Ochiai,Y., Lian,G., Malagola,E., Zheng,B.,
            Tu,R., Zeng,Y., Kobayashi,H., Xia,Z., Wang,R., Peng,Y., Shi,Q.,
            Chen,D., Ryeom,S.W. and Wang,T.C.
  TITLE     Nociceptive neurons promote gastric tumour progression via a
            CGRP-RAMP1 axis
  JOURNAL   Nature 640 (8059), 802-810 (2025)
   PUBMED   39972142
REFERENCE   6  (residues 1 to 128)
  AUTHORS   Ahren,B. and Sundler,F.
  TITLE     Localization of calcitonin gene-related peptide and islet amyloid
            polypeptide in the rat and mouse pancreas
  JOURNAL   Cell Tissue Res 269 (2), 315-322 (1992)
   PUBMED   1423499
REFERENCE   7  (residues 1 to 128)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   8  (residues 1 to 128)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   9  (residues 1 to 128)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   10 (residues 1 to 128)
  AUTHORS   Lalley,P.A., Sakaguchi,A.Y., Eddy,R.L., Honey,N.H., Bell,G.I.,
            Shen,L.P., Rutter,W.J., Jacobs,J.W., Heinrich,G., Chin,W.W. et al.
  TITLE     Mapping polypeptide hormone genes in the mouse: somatostatin,
            glucagon, calcitonin, and parathyroid hormone
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 92-97 (1987)
   PUBMED   2882956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ060164.1, CJ057527.1,
            AF330212.1, BC028771.1, BB749493.1 and BU842988.1.
            
            On Jan 22, 2014 this sequence version replaced XP_006507337.1.
            
            Summary: This gene encodes the peptide hormones calcitonin,
            calcitonin gene-related peptide (CGRP) and katacalcin. Alternative
            splicing of the mRNA results in multiple variants that encode
            either calcitonin or CGRP preproproteins. Post-translational
            processing of the calcitonin and CGRP propeptides results in either
            calcitonin and katacalcin, or CGRP, respectively. Calcitonin and
            katacalcin modulate calcium levels in the blood stream. CGRP can
            function as a vasodilator and play a role in the transmission of
            pain. The human homolog of CGRP was found to have antimicrobial
            activity. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (3) has an altenate splice site in
            the 5' UTR, lacks the 3' terminal exon and has two alternate 3'
            exons, compared to variant 1. The resulting isoform (Cgrp) is
            shorter and has a distinct C-terminus, compared to isoform Calca.
            Both variants 2 and 3 encode the same isoform Cgrp.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC028771.1, AF330212.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.99 cM"
     Protein         1..128
                     /product="calcitonin gene-related peptide 1 isoform Cgrp
                     preproprotein"
                     /note="alpha-type CGRP; calcitonin gene-related peptide I"
                     /calculated_mol_wt=11294
     Region          1..123
                     /region_name="Calc_CGRP_IAPP"
                     /note="Calcitonin / CGRP / IAPP family; pfam00214"
                     /db_xref="CDD:459715"
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     mat_peptide     83..119
                     /product="Calcitonin gene-related peptide 1.
                     /id=PRO_0000004060"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JA0.1)"
                     /calculated_mol_wt=3809
     Site            119
                     /site_type="amidation"
                     /note="Phenylalanine amide. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q99JA0.1)"
     CDS             1..128
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /coded_by="NM_001289444.1:180..566"
                     /note="isoform Cgrp preproprotein is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS21762.1"
                     /db_xref="GeneID:12310"
                     /db_xref="MGI:MGI:2151253"
ORIGIN      
        1 mgflkfspfl vvsilllyqa cslqavplrs ilesspgmat lseeevrlla alvqdymqmk
       61 areleqeeeq eaegssvtaq krscntatcv thrlagllsr sggvvkdnfv ptnvgseafg
      121 rrrrdlqa
//
LOCUS       NP_038591                369 aa            linear   ROD 27-AUG-2025
DEFINITION  cytokine receptor common subunit gamma isoform a precursor [Mus
            musculus].
ACCESSION   NP_038591
VERSION     NP_038591.1
DBSOURCE    REFSEQ: accession NM_013563.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 369)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Matsuda,K., Ide,N., Xu,Y., Iijima,A. and Shibuya,A.
  TITLE     Type 1 innate lymphoid cell-immature neutrophil axis suppresses
            acute tissue inflammation
  JOURNAL   Nat Commun 16 (1), 6574 (2025)
   PUBMED   40675953
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 369)
  AUTHORS   Chiu,R.K., Droll,A., Cooper,D.L., Dougherty,S.T., Dirks,J.F. and
            Dougherty,G.J.
  TITLE     Molecular mechanisms regulating the hyaluronan binding activity of
            the adhesion protein CD44
  JOURNAL   J Neurooncol 26 (3), 231-239 (1995)
   PUBMED   8750189
REFERENCE   5  (residues 1 to 369)
  AUTHORS   He,Y.W. and Malek,T.R.
  TITLE     The IL-2 receptor gamma c chain does not function as a subunit
            shared by the IL-4 and IL-13 receptors. Implication for the
            structure of the IL-4 receptor
  JOURNAL   J Immunol 155 (1), 9-12 (1995)
   PUBMED   7602126
REFERENCE   6  (residues 1 to 369)
  AUTHORS   He,Y.W., Adkins,B., Furse,R.K. and Malek,T.R.
  TITLE     Expression and function of the gamma c subunit of the IL-2, IL-4,
            and IL-7 receptors. Distinct interaction of gamma c in the IL-4
            receptor
  JOURNAL   J Immunol 154 (4), 1596-1605 (1995)
   PUBMED   7530740
REFERENCE   7  (residues 1 to 369)
  AUTHORS   DiSanto,J.P., Certain,S., Wilson,A., MacDonald,H.R., Avner,P.,
            Fischer,A. and de Saint Basile,G.
  TITLE     The murine interleukin-2 receptor gamma chain gene: organization,
            chromosomal localization and expression in the adult thymus
  JOURNAL   Eur J Immunol 24 (12), 3014-3018 (1994)
   PUBMED   7805729
REFERENCE   8  (residues 1 to 369)
  AUTHORS   Cao,X., Kozak,C.A., Liu,Y.J., Noguchi,M., O'Connell,E. and
            Leonard,W.J.
  TITLE     Characterization of cDNAs encoding the murine interleukin 2
            receptor (IL-2R) gamma chain: chromosomal mapping and tissue
            specificity of IL-2R gamma chain expression
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8464-8468 (1993)
   PUBMED   8378320
REFERENCE   9  (residues 1 to 369)
  AUTHORS   Kobayashi,N., Nakagawa,S., Minami,Y., Taniguchi,T. and Kono,T.
  TITLE     Cloning and sequencing of the cDNA encoding a mouse IL-2 receptor
            gamma
  JOURNAL   Gene 130 (2), 303-304 (1993)
   PUBMED   8359699
REFERENCE   10 (residues 1 to 369)
  AUTHORS   Kumaki,S., Kondo,M., Takeshita,T., Asao,H., Nakamura,M. and
            Sugamura,K.
  TITLE     Cloning of the mouse interleukin 2 receptor gamma chain:
            demonstration of functional differences between the mouse and human
            receptors
  JOURNAL   Biochem Biophys Res Commun 193 (1), 356-363 (1993)
   PUBMED   8503926
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683892.12 and AK143669.1.
            
            Summary: This gene encodes a transmembrane protein that is a common
            subunit of several interleukin receptor complexes. These receptors
            are comprised of alpha and beta subunits in addition to this gamma
            subunit. Signalling through this pathway in important in immune
            cell differentiation and function. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143669.1, BC014720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.9 cM"
     Protein         1..369
                     /product="cytokine receptor common subunit gamma isoform a
                     precursor"
                     /note="cytokine receptor common subunit gamma; IL-2R
                     subunit gamma; IL-2 receptor subunit gamma; interleukin-2
                     receptor subunit gamma; gamma C receptor; common gamma
                     chain"
                     /calculated_mol_wt=38932
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3327
     Region          59..>116
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     Region          154..247
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(154,216,237)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(238..239,241..242)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..369
                     /gene="Il2rg"
                     /gene_synonym="CD132; gamma(c); gc; p64; [g]c"
                     /coded_by="NM_013563.4:87..1196"
                     /note="isoform a precursor is encoded by transcript
                     variant a"
                     /db_xref="CCDS:CCDS30312.1"
                     /db_xref="GeneID:16186"
                     /db_xref="MGI:MGI:96551"
ORIGIN      
        1 mlklllsprs flvlqllllr agwsskvlms sanedikadl iltstapehl saptlplpev
       61 qcfvfnieym nctwnsssep qatnltlhyr ykvsdnntfq ecshylfske itsgcqiqke
      121 diqlyqtfvv qlqdpqkpqr ravqklnlqn lviprapenl tlsnlsesql elrwksrhik
      181 erclqylvqy rsnrdrswte livnheprfs lpsvdelkry tfrvrsrynp icgssqqwsk
      241 wsqpvhwgsh tveenpslfa leavlipvgt mgliitlifv ycwlermppi ppiknledlv
      301 teyqgnfsaw sgvskgltes lqpdyserfc hvseippkgg algegpggsp cslhspywpp
      361 pcyslkpea
//
LOCUS       NP_032438                468 aa            linear   ROD 27-AUG-2025
DEFINITION  involucrin [Mus musculus].
ACCESSION   NP_032438
VERSION     NP_032438.2
DBSOURCE    REFSEQ: accession NM_008412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 468)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 468)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   3  (residues 1 to 468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 468)
  AUTHORS   Schmidt,A.D., Miciano,C., Zheng,Q., Mathyer,M.E., Grice,E.A. and de
            Guzman Strong,C.
  TITLE     Involucrin Modulates Vitamin D Receptor Activity in the Epidermis
  JOURNAL   J Invest Dermatol 143 (6), 1052-1061 (2023)
   PUBMED   36642403
  REMARK    GeneRIF: Involucrin Modulates Vitamin D Receptor Activity in the
            Epidermis.
REFERENCE   5  (residues 1 to 468)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   6  (residues 1 to 468)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   7  (residues 1 to 468)
  AUTHORS   Hanley,K., Feingold,K.R., Komuves,L.G., Elias,P.M., Muglia,L.J.,
            Majzoub,J.A. and Williams,M.L.
  TITLE     Glucocorticoid deficiency delays stratum corneum maturation in the
            fetal mouse
  JOURNAL   J Invest Dermatol 111 (3), 440-444 (1998)
   PUBMED   9740238
REFERENCE   8  (residues 1 to 468)
  AUTHORS   Murgia,C., Blaikie,P., Kim,N., Dans,M., Petrie,H.T. and
            Giancotti,F.G.
  TITLE     Cell cycle and adhesion defects in mice carrying a targeted
            deletion of the integrin beta4 cytoplasmic domain
  JOURNAL   EMBO J 17 (14), 3940-3951 (1998)
   PUBMED   9670011
REFERENCE   9  (residues 1 to 468)
  AUTHORS   Gandarillas,A. and Watt,F.M.
  TITLE     The 5' noncoding region of the mouse involucrin gene: comparison
            with the human gene and genes encoding other cornified envelope
            precursors
  JOURNAL   Mamm Genome 6 (9), 680-682 (1995)
   PUBMED   8535084
REFERENCE   10 (residues 1 to 468)
  AUTHORS   Djian,P., Phillips,M., Easley,K., Huang,E., Simon,M., Rice,R.H. and
            Green,H.
  TITLE     The involucrin genes of the mouse and the rat: study of their
            shared repeats
  JOURNAL   Mol Biol Evol 10 (6), 1136-1149 (1993)
   PUBMED   8277848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY142984.1, AA789977.1 and AC125089.4.
            
            On Dec 14, 2005 this sequence version replaced NP_032438.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY142984.1, AA789977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     Protein         1..468
                     /product="involucrin"
                     /calculated_mol_wt=54915
     Region          1..67
                     /region_name="Involucrin_N"
                     /note="Involucrin of squamous epithelia N-terminus;
                     pfam10583"
                     /db_xref="CDD:431372"
     Region          173..211
                     /region_name="Involucrin2"
                     /note="pfam06994"
                     /db_xref="CDD:429235"
     Region          239..278
                     /region_name="Involucrin2"
                     /note="pfam06994"
                     /db_xref="CDD:429235"
     CDS             1..468
                     /gene="Ivl"
                     /gene_synonym="1110019C06Rik"
                     /coded_by="NM_008412.3:68..1474"
                     /db_xref="CCDS:CCDS17561.1"
                     /db_xref="GeneID:16447"
                     /db_xref="MGI:MGI:96626"
ORIGIN      
        1 mshqhtlpvt vpavvqgplk tvcspdhiqq eqakqptphp tqcqvfteiq ekgfpkheek
       61 rpnpvkdlpd qkcehqqqpg pqkqqlqvkk sqqelqeqel hlekqqlpqe pqgllcleqq
      121 qqqepqmqeq hlrqqqqqqq qqqqqqqqqq qqetqeqglc lgqqkqqqqq qdmlvpqelh
      181 lrqhqeklqd pelhlgqqqk tpeeqklipg ekqqelhlgq rhqepqeqel hlgqkqkqkl
      241 hepelqlgkq qhqkpsepel plgkqqqesp epelplgkqq qqespepelq lgkqqqshep
      301 dmagdqkekq klhkpelylr kqqyqespdp elslgkqqhq ecqepelqle ekqhqkppep
      361 elhlgkqqes hepdmaedle ekqklgepel hlgkqqqqqi eregyqgpks lgqslkqeka
      421 srkqqldysh leqekelsdq pldqalvkkg kqlerkkhel enrtqqek
//
LOCUS       NP_001152889             465 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon regulatory factor 9 isoform 1 [Mus musculus].
ACCESSION   NP_001152889
VERSION     NP_001152889.1
DBSOURCE    REFSEQ: accession NM_001159417.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Chavez,C., Lin,K., Malveaux,A., Gorin,A., Brizuela,S., Cheng,Q.J.
            and Hoffmann,A.
  TITLE     IRF1 cooperates with ISGF3 or GAF to form innate immune de novo
            enhancers in macrophages
  JOURNAL   Sci Signal 18 (868), eado8860 (2025)
   PUBMED   39772531
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Lercher,A., Cheong,J.G., Bale,M.J., Jiang,C., Hoffmann,H.H.,
            Ashbrook,A.W., Lewy,T., Yin,Y.S., Quirk,C., DeGrace,E.J.,
            Chiriboga,L., Rosenberg,B.R., Josefowicz,S.Z. and Rice,C.M.
  TITLE     Antiviral innate immune memory in alveolar macrophages following
            SARS-CoV-2 infection ameliorates secondary influenza A virus
            disease
  JOURNAL   Immunity 57 (11), 2530-2546 (2024)
   PUBMED   39353439
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Yadav,S., El Hamra,R., Alturki,N.A., Ariana,A., Bhan,A., Hurley,K.,
            Gaestel,M., Blackshear,P.J., Blais,A. and Sad,S.
  TITLE     Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of
            inflammatory cytokines during necroptosis stimulation
  JOURNAL   Cell Death Dis 15 (8), 574 (2024)
   PUBMED   39117638
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   5  (residues 1 to 465)
  AUTHORS   Lan,C., Zhou,X., Shen,X., Lin,Y., Chen,X., Lin,J., Zhang,Y.,
            Zheng,L. and Yan,S.
  TITLE     Suppression of IRF9 Promotes Osteoclast Differentiation by
            Decreased Ferroptosis via STAT3 Activation
  JOURNAL   Inflammation 47 (1), 99-113 (2024)
   PUBMED   37804406
  REMARK    GeneRIF: Suppression of IRF9 Promotes Osteoclast Differentiation by
            Decreased Ferroptosis via STAT3 Activation.
            Erratum:[Inflammation. 2024 Oct;47(5):1884-1886. doi:
            10.1007/s10753-024-02001-w. PMID: 38488993]
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Weihua,X., Lindner,D.J. and Kalvakolanu,D.V.
  TITLE     The interferon-inducible murine p48 (ISGF3gamma) gene is regulated
            by protooncogene c-myc
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7227-7232 (1997)
   PUBMED   9207073
REFERENCE   7  (residues 1 to 465)
  AUTHORS   Weihua,X., Kolla,V. and Kalvakolanu,D.V.
  TITLE     Interferon gamma-induced transcription of the murine ISGF3gamma
            (p48) gene is mediated by novel factors
  JOURNAL   Proc Natl Acad Sci U S A 94 (1), 103-108 (1997)
   PUBMED   8990168
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Suhara,W., Yoneyama,M., Yonekawa,H. and Fujita,T.
  TITLE     Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3
            gamma/p48) cDNA and chromosomal localization of the gene
  JOURNAL   J Biochem 119 (2), 231-234 (1996)
   PUBMED   8882710
REFERENCE   9  (residues 1 to 465)
  AUTHORS   Kimura,T., Kadokawa,Y., Harada,H., Matsumoto,M., Sato,M.,
            Kashiwazaki,Y., Tarutani,M., Tan,R.S., Takasugi,T., Matsuyama,T.,
            Mak,T.W., Noguchi,S. and Taniguchi,T.
  TITLE     Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in
            both type I and type II interferon responses, as revealed by gene
            targeting studies
  JOURNAL   Genes Cells 1 (1), 115-124 (1996)
   PUBMED   9078371
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Kawakami,T., Matsumoto,M., Sato,M., Harada,H., Taniguchi,T. and
            Kitagawa,M.
  TITLE     Possible involvement of the transcription factor ISGF3 gamma in
            virus-induced expression of the IFN-beta gene
  JOURNAL   FEBS Lett 358 (3), 225-229 (1995)
   PUBMED   7843405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN531811.1, BB860586.1, CK788642.1, U51992.2, BY761438.1 and
            AC174678.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005435.1, ERR3363660.154391.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     Protein         1..465
                     /product="interferon regulatory factor 9 isoform 1"
                     /note="ISGF-3 gamma; ISGF3 p48 subunit;
                     interferon-stimulated gene factor 3 gamma; transcriptional
                     regulator ISGF3 subunit gamma; IFN-alpha-responsive
                     transcription factor subunit; interferon dependent
                     positive acting transcription factor 3 gamma"
                     /calculated_mol_wt=51351
     Region          77..181
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(110,149,151..152,155)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            order(154..155,157,160)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          277..443
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:463076"
     CDS             1..465
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /coded_by="NM_001159417.1:149..1546"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49496.1"
                     /db_xref="GeneID:16391"
                     /db_xref="MGI:MGI:107587"
ORIGIN      
        1 mhlpggelkl rvgtvergge irkslepakp gtfsaaqalp issapplppa aapptplakr
       61 gmvrrrmasg kvrctrklrs wiveqvesgh fpgvcwddaa ktmfripwkh agkqdfredq
      121 daaifkawal fkekhkdgdi ghpavwktrl rcalnkssef eevpergrmd vaepykvyri
      181 lpagtlpnqp rnqkspckrs iscvsperee nmengrtngv vnhsdsgsni ggggngsnrs
      241 dsnsncnsel eegagtteat iredpvfleh qlplnsdysl lltfiyggrv vgktqvhsld
      301 crlvaersds essmeqvefp kpdpleptqh llnqldrgvl vasnsrglfv qrlcpipisw
      361 napeappgpg phllpsnkcv elfkttyfcr dlaqyfqgqg pppkfqatlh fweespgssh
      421 sqenlitvqm eqafarhlle kipeeekaal fllqhteqsp salgh
//
LOCUS       NP_001155314             372 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-18 receptor 1 isoform b precursor [Mus musculus].
ACCESSION   NP_001155314
VERSION     NP_001155314.1
DBSOURCE    REFSEQ: accession NM_001161842.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 372)
  AUTHORS   Shen,J., Zhang,Y., Tang,W., Yang,M., Cheng,T., Chen,Y., Yu,S.,
            Guo,Q., Cao,L., Wang,X., Xiao,H., Wang,L., Wang,C., Liu,C.Y. and
            Meng,G.
  TITLE     Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to
            suppress tumor growth
  JOURNAL   Nat Immunol 26 (3), 416-428 (2025)
   PUBMED   39891018
REFERENCE   2  (residues 1 to 372)
  AUTHORS   Zhang,X., Li,S., Lason,W., Greco,M., Klenerman,P. and Hinks,T.S.C.
  TITLE     MAIT cells protect against sterile lung injury
  JOURNAL   Cell Rep 44 (2), 115275 (2025)
   PUBMED   39918959
REFERENCE   3  (residues 1 to 372)
  AUTHORS   McManus,R.M., Komes,M.P., Griep,A., Santarelli,F., Schwartz,S.,
            Ramon Perea,J., Schlachetzki,J.C.M., Bouvier,D.S., Khalil,M.A.,
            Lauterbach,M.A., Heinemann,L., Schluter,T., Pour,M.S., Lovotti,M.,
            Stahl,R., Duthie,F., Rodriguez-Alcazar,J.F., Schmidt,S.V.,
            Spitzer,J., Noori,P., Maillo,A., Boettcher,A., Herron,B.,
            McConville,J., Gomez-Cabrero,D., Tegner,J., Glass,C.K., Hiller,K.,
            Latz,E. and Heneka,M.T.
  TITLE     NLRP3-mediated glutaminolysis controls microglial phagocytosis to
            promote Alzheimer's disease progression
  JOURNAL   Immunity 58 (2), 326-343 (2025)
   PUBMED   39904338
REFERENCE   4  (residues 1 to 372)
  AUTHORS   Slusny,B., Zimmer,V., Nasiri,E., Lutz,V., Huber,M., Buchholz,M.,
            Gress,T.M., Roth,K. and Bauer,C.
  TITLE     Optimized Spheroid Model of Pancreatic Cancer Demonstrates
            Influence of Macrophage-T Cell Interaction for Intratumoral T Cell
            Motility
  JOURNAL   Cancers (Basel) 17 (1), 51 (2024)
   PUBMED   39796680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 372)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   6  (residues 1 to 372)
  AUTHORS   Sergi,B. and Penttila,I.
  TITLE     Interleukin 18 receptor
  JOURNAL   J Biol Regul Homeost Agents 18 (1), 55-61 (2004)
   PUBMED   15323361
  REMARK    GeneRIF: review of structure, function and tissue distribution of
            IL-18R [review]
            Review article
REFERENCE   7  (residues 1 to 372)
  AUTHORS   Seki,E., Tsutsui,H., Tsuji,N.M., Hayashi,N., Adachi,K., Nakano,H.,
            Futatsugi-Yumikura,S., Takeuchi,O., Hoshino,K., Akira,S.,
            Fujimoto,J. and Nakanishi,K.
  TITLE     Critical roles of myeloid differentiation factor 88-dependent
            proinflammatory cytokine release in early phase clearance of
            Listeria monocytogenes in mice
  JOURNAL   J Immunol 169 (7), 3863-3868 (2002)
   PUBMED   12244183
REFERENCE   8  (residues 1 to 372)
  AUTHORS   Okamoto,M., Kato,S., Oizumi,K., Kinoshita,M., Inoue,Y., Hoshino,K.,
            Akira,S., McKenzie,A.N., Young,H.A. and Hoshino,T.
  TITLE     Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung
            injury in mice: a potential role for cytokines, chemokines, and
            natural killer cells in the pathogenesis of interstitial pneumonia
  JOURNAL   Blood 99 (4), 1289-1298 (2002)
   PUBMED   11830478
REFERENCE   9  (residues 1 to 372)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
REFERENCE   10 (residues 1 to 372)
  AUTHORS   Parnet,P., Garka,K.E., Bonnert,T.P., Dower,S.K. and Sims,J.E.
  TITLE     IL-1Rrp is a novel receptor-like molecule similar to the type I
            interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
  JOURNAL   J Biol Chem 271 (8), 3967-3970 (1996)
   PUBMED   8626725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167126.6.
            
            Transcript Variant: This variant (2) uses an alternate splice
            pattern in the 5' UTR and 5' coding region, compared to variant 1.
            The resulting isoform (b) has a shorter and distinct C-terminus,
            compared to isoform a. Both variants 2 and 3 encode the same
            isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 19.27 cM"
     Protein         1..372
                     /product="interleukin-18 receptor 1 isoform b precursor"
                     /EC_number="3.2.2.6"
                     /note="interleukin 1 receptor related protein; IL-18R1;
                     IL-1Rrp; IL1R-rp; IL-18R-1; IL-18Ralpha; IL1
                     receptor-related protein; CD218 antigen-like family member
                     A; IL-18R-alpha; interleukin-18 receptor alpha"
                     /calculated_mol_wt=40414
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2151
     Region          3..>98
                     /region_name="Ig_6"
                     /note="Immunoglobulin domain; pfam18452"
                     /db_xref="CDD:465773"
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            71
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            107
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            111
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          131..205
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          137..141
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409415"
     Region          149..156
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409415"
     Region          <157..257
                     /region_name="PHA02785"
                     /note="IL-beta-binding protein; Provisional"
                     /db_xref="CDD:165149"
     Region          179..184
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409415"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409415"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          212..312
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          230..234
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409526"
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          243..246
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409526"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409526"
     Region          293..298
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409526"
     Site            295
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61098.1)"
     Region          306..309
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409526"
     Site            327..347
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61098.1)"
     CDS             1..372
                     /gene="Il18r1"
                     /gene_synonym="Il18ralpha; Il1rrp"
                     /coded_by="NM_001161842.1:456..1574"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS48247.1"
                     /db_xref="GeneID:16182"
                     /db_xref="MGI:MGI:105383"
ORIGIN      
        1 mhheeliltl cilivksask scihrsqihv vegepfylkp cgisapvhrn etatmrwfkg
       61 sasheyreln nrssprvtfh dhtlefwpve medegtyisq vgndrrnwtl nvtkrnkhsc
      121 fsdklvtsrd vevnkslhit cknpnyeeli qdtwlyknck eisktprilk daefgdegyy
      181 scvfsvhhng trynitktvn itviegrskv tpailgpkce kvgvelgkdv elncsaslnk
      241 ddlfywsirk edssdpnvqe drketttwis egklhaskil rfqkitenyl nvlynctvan
      301 eeaidtksfv lvrkeipdip ghvftggvtv lvlasvaavc ivilcviykv dlvlfyrria
      361 erdetltgnm ll
//
LOCUS       NP_001404377             397 aa            linear   ROD 27-AUG-2025
DEFINITION  tyrosinase isoform 3 precursor [Mus musculus].
ACCESSION   NP_001404377 XP_006507640
VERSION     NP_001404377.1
DBSOURCE    REFSEQ: accession NM_001417448.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Kohne,M., Shakiba,M.H., Schmidleithner,L., Schulte-Schrepping,J.,
            Scholz,R., Elmzzahi,T., Sommer,D., Li,Y., Carraro,C., De
            Domenico,E., Wissfeld,J., Handler,K., Hamada,D., Frolov,A.,
            Cheng,X., Baumgart,A.K., Holsten,L., Osei-Sarpong,C., Bourry,S.,
            Thabet,Y., Renken,H., Paulusch,S., Sadlon,T., Buch,T.,
            Wunderlich,F.T., Wickenhauser,C., Alferink,J., Kuhlmann,T.,
            Geyer,M., Bonaguro,L., Barry,S.C., Schultze,J.L. and Beyer,M.D.
  TITLE     Satb1 directs the differentiation of TH17 cells through suppression
            of IL-2 expression
  JOURNAL   Cell Rep 44 (7), 115866 (2025)
   PUBMED   40531625
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Koch,J., Neumann,L., Lackner,K., Fernandez-Quintero,M.L.,
            Watschinger,K. and Keller,M.A.
  TITLE     Benchmarking of Trapped Ion Mobility Spectrometry in
            Differentiating Plasmalogens from Other Ether Lipids in Lipidomics
            Experiments
  JOURNAL   Anal Chem 97 (20), 10578-10587 (2025)
   PUBMED   40358456
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Mihlan,M., Wissmann,S., Gavrilov,A., Kaltenbach,L., Britz,M.,
            Franke,K., Hummel,B., Imle,A., Suzuki,R., Stecher,M., Glaser,K.M.,
            Lorentz,A., Carmeliet,P., Yokomizo,T., Hilgendorf,I., Sawarkar,R.,
            Diz-Munoz,A., Buescher,J.M., Mittler,G., Maurer,M., Krause,K.,
            Babina,M., Erpenbeck,L., Frank,M., Rambold,A.S. and Lammermann,T.
  TITLE     Neutrophil trapping and nexocytosis, mast cell-mediated processes
            for inflammatory signal relay
  JOURNAL   Cell 187 (19), 5316-5335 (2024)
   PUBMED   39096902
REFERENCE   5  (residues 1 to 397)
  AUTHORS   Zhao,J., Kim,H.J., Montenegro,D., Dunaief,J.L. and Sparrow,J.R.
  TITLE     Iron overload and chelation modulates bisretinoid levels in the
            retina
  JOURNAL   Front Ophthalmol (Lausanne) 3, 1305864 (2023)
   PUBMED   38983013
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 397)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (residues 1 to 397)
  AUTHORS   Gluecksohn-Waelsch,S.
  TITLE     Genetic control of morphogenetic and biochemical differentiation:
            lethal albino deletions in the mouse
  JOURNAL   Cell 16 (2), 225-237 (1979)
   PUBMED   36985
  REMARK    Review article
REFERENCE   8  (residues 1 to 397)
  AUTHORS   Cowing,C., Harris,D., Garabedian,C., Lukic,M. and Leskowitz,S.
  TITLE     Immunologic tolerance to heterologous immunoglobulin: its relation
            to in vitro filtration by macrophages
  JOURNAL   J Immunol 119 (1), 256-262 (1977)
   PUBMED   68973
REFERENCE   9  (residues 1 to 397)
  AUTHORS   Freund,J.G., Ahmed,A., Budd,R.E., Dorf,M.E., Sell,K.W.,
            Vannier,W.E. and Humphreys,R.E.
  TITLE     The L1210 leukemia cell bears a B lymphocyte specific, non-H-2
            linked alloantigen
  JOURNAL   J Immunol 117 (5 Pt.2), 1903-1905 (1976)
   PUBMED   62795
REFERENCE   10 (residues 1 to 397)
  AUTHORS   Garland,R.C., Satrustegui,J., Gluecksohn-Waelsch,S. and Cori,C.F.
  TITLE     Deficiency in plasma protein synthesis caused by x-ray-incuded
            lethal albino alleles in mouse
  JOURNAL   Proc Natl Acad Sci U S A 73 (10), 3376-3380 (1976)
   PUBMED   62358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122517.2.
            
            On Mar 4, 2023 this sequence version replaced XP_006507640.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148357.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 49.01 cM"
     Protein         1..397
                     /product="tyrosinase isoform 3 precursor"
                     /EC_number="1.14.18.1"
                     /note="monophenol monooxygenase; albino locus protein"
                     /calculated_mol_wt=42609
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2107
     Site            86
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     Site            111
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     Site            161
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     Region          171..396
                     /region_name="Tyrosinase"
                     /note="Common central domain of tyrosinase; pfam00264"
                     /db_xref="CDD:425566"
     Site            230
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     Site            337
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     Site            371
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P11344.3)"
     CDS             1..397
                     /gene="Tyr"
                     /gene_synonym="albino; c; Oca1; skc35"
                     /coded_by="NM_001417448.1:80..1273"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="GeneID:22173"
                     /db_xref="MGI:MGI:98880"
ORIGIN      
        1 mflavlycll wsfqisdghf pracassknl lakeccppwm gdgspcgqls grgscqdill
       61 ssapsgpqfp fkgvddresw psvfynrtcq csgnfmgfnc gnckfgfggp nctekrvlir
      121 rnifdlsvse knkffsyltl akhtissvyv iptgtygqmn ngstpmfndi niydlfvwmh
      181 yyvsrdtllg gseiwrdidf aheapgflpw hrlflllweq eireltgden ftvpywdwrd
      241 aencdictde ylggrhpenp nllspasffs swqiicsrse eynshqvlcd gtpegpllrn
      301 pgnhdkaktp rlpssadvef clsltqyesg smdrtanfsf rntlegfasp ltgiadpsqs
      361 smhnalhifm ngtmsqvqgs andpifllhh afvdrlv
//
LOCUS       NP_001012402             342 aa            linear   ROD 27-AUG-2025
DEFINITION  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1 [Mus
            musculus].
ACCESSION   NP_001012402 XP_283407 XP_484613
VERSION     NP_001012402.1
DBSOURCE    REFSEQ: accession NM_001012402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 342)
  AUTHORS   Patel,V.N., Ball,J.R., Choi,S.H., Lane,E.D., Wang,Z., Aure,M.H.,
            Villapudua,C.U., Zheng,C., Bleck,C., Mohammed,H., Syed,Z., Liu,J.
            and Hoffman,M.P.
  CONSRTM   NIDCD/NIDCR Genomics and Computational Biology Core
  TITLE     Loss of 3-O-sulfotransferase enzymes, Hs3st3a1 and Hs3st3b1,
            reduces kidney and glomerular size and disrupts glomerular
            architecture
  JOURNAL   Matrix Biol 133, 134-149 (2024)
   PUBMED   38944161
REFERENCE   2  (residues 1 to 342)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 342)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
REFERENCE   4  (residues 1 to 342)
  AUTHORS   Athwal,H.K., Murphy,G. 3rd, Tibbs,E., Cornett,A., Hill,E., Yeoh,K.,
            Berenstein,E., Hoffman,M.P. and Lombaert,I.M.A.
  TITLE     Sox10 Regulates Plasticity of Epithelial Progenitors toward
            Secretory Units of Exocrine Glands
  JOURNAL   Stem Cell Reports 12 (2), 366-380 (2019)
   PUBMED   30713042
REFERENCE   5  (residues 1 to 342)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 342)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 342)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 342)
  AUTHORS   Motamedi,F.J., Badro,D.A., Clarkson,M., Lecca,M.R., Bradford,S.T.,
            Buske,F.A., Saar,K., Hubner,N., Brandli,A.W. and Schedl,A.
  TITLE     WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal
            progenitors
  JOURNAL   Nat Commun 5, 4444 (2014)
   PUBMED   25031030
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 342)
  AUTHORS   Xu,D., Tiwari,V., Xia,G., Clement,C., Shukla,D. and Liu,J.
  TITLE     Characterization of heparan sulphate 3-O-sulphotransferase isoform
            6 and its role in assisting the entry of herpes simplex virus type
            1
  JOURNAL   Biochem J 385 (Pt 2), 451-459 (2005)
   PUBMED   15303968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146974.1 and AY574375.1.
            
            On or before Feb 25, 2005 this sequence version replaced
            XP_283407.1, XP_484613.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY574375.1, BC132520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     Protein         1..342
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     6 isoform 1"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate D-glucosaminyl 3-O-sulfotransferase
                     6"
                     /calculated_mol_wt=37284
     Site            32..49
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GFD5.1)"
     Region          56..75
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5GFD5.1)"
     Region          91..326
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; pfam00685"
                     /db_xref="CDD:425820"
     Site            281
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5GFD5.1)"
     CDS             1..342
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /coded_by="NM_001012402.2:99..1127"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28496.1"
                     /db_xref="GeneID:328779"
                     /db_xref="MGI:MGI:3580487"
ORIGIN      
        1 magsgglggg agdlqgagtg qgtalralra plalvvllls ayclfalpgr cppaarapap
       61 vpapaeppht slrlrapglp vasgpgrrrf pqalivgvkk ggtrallefl rlhpdvralg
      121 sephffdrcy drglawyrgl mprtldgqit mektpsyfvt qeaprrihgm spdtklivvv
      181 rnpvtraisd yaqtlsktpg lpsfralafr hglgpvdtaw savriglyaq hldnwlryfp
      241 lshflfvsge rlvsdpagev grvqdflglk rvvtdkhfyf natkgfpclk kaqgsgrprc
      301 lgkskgrphp rvpeavvqrl qafyrpfnrk fyqmtgqdfg wd
//
LOCUS       NP_001395640             158 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
            [Mus musculus].
ACCESSION   NP_001395640
VERSION     NP_001395640.1
DBSOURCE    REFSEQ: accession NM_001408711.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 158)
  AUTHORS   Shipman,G.A., Padilla,R., Horth,C., Hu,B., Bareke,E.,
            Vitorino,F.N., Gongora,J.M., Garcia,B.A., Lu,C. and Majewski,J.
  TITLE     Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L
            reveal their distinct contributions to H3K36 methylation
  JOURNAL   Genome Biol 25 (1), 263 (2024)
   PUBMED   39390582
  REMARK    GeneRIF: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and
            ASH1L reveal their distinct contributions to H3K36 methylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 158)
  AUTHORS   Kinoshita,S., Kojima,K., Ohnishi,E., Takayama,Y., Kikuchi,H.,
            Takada,S., Nakabayashi,K., Kawai,T. and Hata,K.
  TITLE     Loss of NSD2 causes dysregulation of synaptic genes and altered
            H3K36 dimethylation in mice
  JOURNAL   Front Genet 15, 1308234 (2024)
   PUBMED   38419783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 158)
  AUTHORS   Shao,R., Suo,J., Zhang,Z., Kong,M., Ma,Y., Wen,Y., Liu,M.,
            Zhuang,L., Ge,K., Bi,Q., Zhang,C. and Zou,W.
  TITLE     H3K36 methyltransferase NSD1 protects against osteoarthritis
            through regulating chondrocyte differentiation and cartilage
            homeostasis
  JOURNAL   Cell Death Differ 31 (1), 106-118 (2024)
   PUBMED   38012390
  REMARK    GeneRIF: H3K36 methyltransferase NSD1 protects against
            osteoarthritis through regulating chondrocyte differentiation and
            cartilage homeostasis.
REFERENCE   4  (residues 1 to 158)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
  REMARK    GeneRIF: Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities.
REFERENCE   5  (residues 1 to 158)
  AUTHORS   Chen,C., Shin,J.H., Fang,Z., Brennan,K., Horowitz,N.B., Pfaff,K.L.,
            Welsh,E.L., Rodig,S.J., Gevaert,O., Gozani,O., Uppaluri,R. and
            Sunwoo,J.B.
  TITLE     Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Cancer Res 83 (16), 2645-2655 (2023)
   PUBMED   37311054
  REMARK    GeneRIF: Targeting KDM2A Enhances T-cell Infiltration in
            NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
REFERENCE   6  (residues 1 to 158)
  AUTHORS   Rayasam,G.V., Wendling,O., Angrand,P.O., Mark,M., Niederreither,K.,
            Song,L., Lerouge,T., Hager,G.L., Chambon,P. and Losson,R.
  TITLE     NSD1 is essential for early post-implantation development and has a
            catalytically active SET domain
  JOURNAL   EMBO J 22 (12), 3153-3163 (2003)
   PUBMED   12805229
  REMARK    GeneRIF: Data show that nuclear receptor-binding SET
            domain-containing protein (NSD1) is a developmental regulatory
            protein with histone methyltransferase activity that exerts
            function(s) essential for early post-implantation development.
REFERENCE   7  (residues 1 to 158)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 158)
  AUTHORS   Kurotaki,N., Harada,N., Yoshiura,K., Sugano,S., Niikawa,N. and
            Matsumoto,N.
  TITLE     Molecular characterization of NSD1, a human homologue of the mouse
            Nsd1 gene
  JOURNAL   Gene 279 (2), 197-204 (2001)
   PUBMED   11733144
REFERENCE   9  (residues 1 to 158)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 158)
  AUTHORS   Huang,N., vom Baur,E., Garnier,J.M., Lerouge,T., Vonesch,J.L.,
            Lutz,Y., Chambon,P. and Losson,R.
  TITLE     Two distinct nuclear receptor interaction domains in NSD1, a novel
            SET protein that exhibits characteristics of both corepressors and
            coactivators
  JOURNAL   EMBO J 17 (12), 3398-3412 (1998)
   PUBMED   9628876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160958.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422592.288130.1,
                                           SRR9219381.93441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     Protein         1..158
                     /product="histone-lysine N-methyltransferase, H3 lysine-36
                     specific isoform 6"
                     /EC_number="2.1.1.357"
                     /note="histone-lysine N-methyltransferase, H3 lysine-36
                     and H4 lysine-20 specific; H3-K36-HMTase; H4-K20-HMTase;
                     NR-binding SET domain-containing protein; nuclear
                     receptor-binding SET domain-containing protein 1;
                     histone-lysine N-methyltransferase, H3 lysine-36 specific"
                     /calculated_mol_wt=17918
     Region          49..143
                     /region_name="PWWP"
                     /note="PWWP (Pro-Trp-Trp-Pro) domain; cl02554"
                     /db_xref="CDD:470613"
     Site            order(65,68,99)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438958"
     Site            66..69
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438958"
     CDS             1..158
                     /gene="Nsd1"
                     /gene_synonym="KMT3B"
                     /coded_by="NM_001408711.1:134..610"
                     /note="isoform 6 is encoded by transcript variant 15"
                     /db_xref="GeneID:18193"
                     /db_xref="MGI:MGI:1276545"
ORIGIN      
        1 mppktrtals ddpdsspspl gnmleipgts spstsqelpf cqpkkkstpl kyevgdliwa
       61 kfkrrpwwpc ricsdplint hskmkvanrr pyreyyveaf gdpsekawva gkaivmfegr
      121 hqfeelpvlr krgkqkekgy rhktgflcva lavleltl
//
LOCUS       NP_001409022             466 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1A adrenergic receptor isoform 1 [Mus musculus].
ACCESSION   NP_001409022 XP_036014300
VERSION     NP_001409022.1
DBSOURCE    REFSEQ: accession NM_001422093.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Gural,B., Kirkland,L., Hockett,A., Sandroni,P., Zhang,J.,
            Rosa-Garrido,M., Swift,S.K., Chapski,D.J., Flinn,M.A.,
            O'Meara,C.C., Vondriska,T.M., Patterson,M., Jensen,B.C. and
            Rau,C.D.
  TITLE     Novel insights into post-myocardial infarction cardiac remodeling
            through algorithmic detection of cell-type composition shifts
  JOURNAL   PLoS Genet 21 (7), e1011807 (2025)
   PUBMED   40705823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Docherty,J.R.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Lin,F., Owens,W.A., Chen,S., Stevens,M.E., Kesteven,S.,
            Arthur,J.F., Woodcock,E.A., Feneley,M.P. and Graham,R.M.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (residues 1 to 466)
  AUTHORS   O'Connell,T.D., Rokosh,D.G. and Simpson,P.C.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Xiao,L., Scofield,M.A. and Jeffries,W.B.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (residues 1 to 466)
  AUTHORS   Rockman,H.A., Koch,W.J. and Lefkowitz,R.J.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (residues 1 to 466)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129570.10 and AC154693.2.
            
            On Jun 1, 2023 this sequence version replaced XP_036014300.1.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.280553.1, AF031431.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     Protein         1..466
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /note="alpha-1A adrenergic receptor; alpha-1A
                     adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic
                     receptor"
                     /calculated_mol_wt=51613
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Region          27..337
                     /region_name="7tmA_alpha1A_AR"
                     /note="alpha-1 adrenergic receptors subtype A, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15325"
                     /db_xref="CDD:320448"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320448"
     Site            28..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          61..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320448"
     Site            65..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          99..129
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320448"
     Site            100..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            order(102,106..107,110..111,178,185,188..189,192,285,
                     288..289,292,308,312,316)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320448"
     Region          141..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320448"
     Site            144..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320448"
     Site            182..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          265..295
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320448"
     Site            274..297
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          305..330
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320448"
     Site            306..329
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          334..349
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     CDS             1..466
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /coded_by="NM_001422093.1:889..2289"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
ORIGIN      
        1 mvllsenase gsncthppaq vniskaillg vilggliifg vlgnilvils vachrhlhsv
       61 thyyivnlav adllltstvl pfsaifeilg ywafgrvfcn iwaavdvlcc tasimglcii
      121 sidryigvsy plryptivtq rrgvrallcv walslvisig plfgwrqqap edeticqine
      181 epgyvlfsal gsfyvpltii lvmycrvyvv akresrglks glktdksdse qvtlrihrkn
      241 vpaegsgvss aknkthfsvr llkfsrekka aktlgivvgc fvlcwlpffl vmpigsffpn
      301 fkppetvfki vfwlgylnsc inpiiypcss qefkkafqnv lriqclrrrq sskhalgytl
      361 hppsqavegq hrgmvripvg sgetfykisk tdgvrewkff ssmpqgsari tmpkdqsact
      421 tarvrsksfl qvcccvgsst prpeenhqvp tikihtislg engeev
//
LOCUS       NP_848919               1521 aa            linear   ROD 27-AUG-2025
DEFINITION  slit homolog 2 protein isoform c precursor [Mus musculus].
ACCESSION   NP_848919
VERSION     NP_848919.3
DBSOURCE    REFSEQ: accession NM_178804.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1521)
  AUTHORS   Santos-Cantador,J., Siguero-Alvarez,M. and de la Pompa,J.L.
  TITLE     Patterning Defects in Mice with Defective Ventricular Wall
            Maturation and Cardiomyopathy
  JOURNAL   J Cardiovasc Dev Dis 12 (6), 224 (2025)
   PUBMED   40558659
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1521)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1521)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1521)
  AUTHORS   Rama,N., Dubrac,A., Mathivet,T., Ni Charthaigh,R.A., Genet,G.,
            Cristofaro,B., Pibouin-Fragner,L., Ma,L., Eichmann,A. and
            Chedotal,A.
  TITLE     Slit2 signaling through Robo1 and Robo2 is required for retinal
            neovascularization
  JOURNAL   Nat Med 21 (5), 483-491 (2015)
   PUBMED   25894826
  REMARK    GeneRIF: Slit2 signaling through Robo1 and Robo2 has a role in
            retinal neovascularization
REFERENCE   5  (residues 1 to 1521)
  AUTHORS   Grieshammer,U., Le,Ma., Plump,A.S., Wang,F., Tessier-Lavigne,M. and
            Martin,G.R.
  TITLE     SLIT2-mediated ROBO2 signaling restricts kidney induction to a
            single site
  JOURNAL   Dev Cell 6 (5), 709-717 (2004)
   PUBMED   15130495
  REMARK    GeneRIF: Mutants lacking SLIT2 develop supernumerary ureteric buds
            that remain inappropriately connected to the nephric duct; the
            SLIT2 signal is transduced in the nephrogenic mesenchyme.
REFERENCE   6  (residues 1 to 1521)
  AUTHORS   Bagri,A., Marin,O., Plump,A.S., Mak,J., Pleasure,S.J.,
            Rubenstein,J.L. and Tessier-Lavigne,M.
  TITLE     Slit proteins prevent midline crossing and determine the
            dorsoventral position of major axonal pathways in the mammalian
            forebrain
  JOURNAL   Neuron 33 (2), 233-248 (2002)
   PUBMED   11804571
REFERENCE   7  (residues 1 to 1521)
  AUTHORS   Plump,A.S., Erskine,L., Sabatier,C., Brose,K., Epstein,C.J.,
            Goodman,C.S., Mason,C.A. and Tessier-Lavigne,M.
  TITLE     Slit1 and Slit2 cooperate to prevent premature midline crossing of
            retinal axons in the mouse visual system
  JOURNAL   Neuron 33 (2), 219-232 (2002)
   PUBMED   11804570
REFERENCE   8  (residues 1 to 1521)
  AUTHORS   Li,H.S., Chen,J.H., Wu,W., Fagaly,T., Zhou,L., Yuan,W., Dupuis,S.,
            Jiang,Z.H., Nash,W., Gick,C., Ornitz,D.M., Wu,J.Y. and Rao,Y.
  TITLE     Vertebrate slit, a secreted ligand for the transmembrane protein
            roundabout, is a repellent for olfactory bulb axons
  JOURNAL   Cell 96 (6), 807-818 (1999)
   PUBMED   10102269
REFERENCE   9  (residues 1 to 1521)
  AUTHORS   Hassoun,H., Hanada,T., Lutchman,M., Sahr,K.E., Palek,J., Hanspal,M.
            and Chishti,A.H.
  TITLE     Complete deficiency of glycophorin A in red blood cells from mice
            with targeted inactivation of the band 3 (AE1) gene
  JOURNAL   Blood 91 (6), 2146-2151 (1998)
   PUBMED   9490702
REFERENCE   10 (residues 1 to 1521)
  AUTHORS   Maekawa,T.L., Takahashi,T.A., Fujihara,M., Urushibara,N.,
            Kadowaki-Kikuchi,E., Nishikawa,M., Ikebuchi,K., Asano,S., Ozawa,K.
            and Sekiguchi,S.
  TITLE     A novel gene (drad-1) expressed in hematopoiesis-supporting stromal
            cell lines, ST2, PA6 and A54 preadipocytes: use of mRNA
            differential display
  JOURNAL   Stem Cells 15 (5), 334-339 (1997)
   PUBMED   9323794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053182.1, BC079911.1,
            AK033292.1, AC101004.6, AW556809.1 and BE944330.1.
            
            On Jan 24, 2008 this sequence version replaced NP_848919.2.
            
            Summary: The protein encoded by this gene is a member of the Slit
            family of secreted glycoproteins, which function as ligands for the
            Robo family of immunoglobulin receptors. Slit proteins play highly
            conserved roles in axon guidance and neuronal migration and may
            also have functions during other cell migration processes including
            leukocyte migration. In mammals, members of the slit family are
            characterized by an N-terminal signal peptide, four leucine-rich
            repeats, nine epidermal growth factor repeats, and a C-terminal
            cysteine knot. Mice deficient for this gene exhibit abnormal axonal
            projections in the embryonic forebrain and develop supernumerary
            uretic buds that maintain improper connections to the nephric duct.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) lacks three alternate in-frame
            exons compared to variant 1. The encoded isoform (c) is shorter
            than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079911.1, AF144628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 26.05 cM"
     Protein         1..1521
                     /product="slit homolog 2 protein isoform c precursor"
                     /note="slit homolog 2 protein; neurogenic extracellular
                     slit protein; downregulated during adipocyte
                     differentiation-1"
                     /calculated_mol_wt=166204
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=2598
     mat_peptide     26..1521
                     /product="Slit homolog 2 protein. /id=PRO_0000007728"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=166204
     mat_peptide     26..1113
                     /product="Slit homolog 2 protein N-product.
                     /evidence=ECO:0000250. /id=PRO_0000007729"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=121631
     Region          27..58
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          38..56
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <56..>211
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          56..77
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          57..80
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          80..101
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          81..104
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          104..125
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          128..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          152..173
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          153..176
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          176..197
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          177..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..>319
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Site            186
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          201..325
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <283..>452
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          301..322
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          325..346
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          326..349
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          349..370
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          350..370
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          373..394
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          374..397
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          397..418
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          398..419
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          422..515
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <507..>658
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          516..551
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          526..547
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          551..572
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          552..575
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            556
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          575..596
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          576..599
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          599..620
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          600..623
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            615
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          623..644
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          624..645
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          629..>705
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          648..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <728..>853
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          740..770
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          747..769
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          770..791
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          771..794
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            786
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            791
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          794..815
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          795..818
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          818..839
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          819..840
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          824..>1005
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          990..1026
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(990,993,1007)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1001
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1002
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1011
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          1030..1065
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1068..1104
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1068,1071,1085)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1113..1114
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     mat_peptide     1114..1521
                     /product="Slit homolog 2 protein C-product.
                     /evidence=ECO:0000250. /id=PRO_0000007730"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=44591
     Region          1175..1308
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Site            1175
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1258
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1292
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     CDS             1..1521
                     /gene="Slit2"
                     /gene_synonym="b2b1200.1Clo; Drad-1; E030015M03Rik;
                     E130320P19Rik; mKIAA4141; Slil3; slit-2"
                     /coded_by="NM_178804.5:1886..6451"
                     /note="isoform c precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS19280.1"
                     /db_xref="GeneID:20563"
                     /db_xref="MGI:MGI:1315205"
ORIGIN      
        1 msgigwqtls lslglvlsil nkvapqacpa qcscsgstvd chglalrsvp rniprnterl
       61 dlngnnitri tkidfaglrh lrvlqlmenr istiergafq dlkelerlrl nrnnlqlfpe
      121 llflgtakly rldlsenqiq aiprkafrga vdiknlqldy nqisciedga fralrdlevl
      181 tlnnnnitrl svasfnhmpk lrtfrlhsnn lycdchlawl sdwlrqrprv glytqcmgps
      241 hlrghnvaev qkrefvcsgh qsfmapscsv lhcpaactcs nnivdcrgkg lteiptnlpe
      301 titeirleqn sirvippgaf spykklrrld lsnnqisela pdafqglrsl nslvlygnki
      361 telpkslfeg lfslqlllln ankinclrvd afqdlhnlnl lslydnklqt vakgtfsalr
      421 aiqtmhlaqn pficdchlkw ladylhtnpi etsgarctsp rrlankrigq ikskkfrcsg
      481 tedyrsklsg dcfadlacpe kcrcegttvd csnqrlnkip dhipqytael rlnnneftvl
      541 eatgifkklp qlrkinfsnn kitdieegaf egasgvneil ltsnrlenvq hkmfkglesl
      601 ktlmlrsnri scvgndsfig lgsvrllsly dnqittvapg afdslhslst lnllanpfnc
      661 nchlawlgew lrrkrivtgn prcqkpyflk eipiqdvaiq dftcddgndd nscsplsrcp
      721 sectcldtvv rcsnkglkvl pkgipkdvte lyldgnqftl vpkelsnykh ltlidlsnnr
      781 istlsnqsfs nmtqlltlil synrlrcipp rtfdglkslr llslhgndis vvpegafndl
      841 salshlaiga nplycdcnmq wlsdwvksey kepgiarcag pgemadklll ttpskkftcq
      901 gpvditiqak cnpclsnpck ndgtcnndpv dfyrctcpyg fkgqdcdvpi hacisnpckh
      961 ggtchlkege nagfwctcad gfegencevn iddcedndce nnstcvdgin nytclcppey
     1021 tgelceekld fcaqdlnpcq hdskciltpk gfkcdctpgy igehcdidfd dcqdnkckng
     1081 ahctdavngy tcvcpegysg lfcefsppmv lprtspcdnf dcqngaqcii rinepicqcl
     1141 pgylgekcek lvsvnfvnke sylqipsakv rpqtnitlqi atdedsgill ykgdkdhiav
     1201 elyrgrvras ydtgshpasa iysvetindg nfhivelltl dsslslsvdg gspkvitnls
     1261 kqstlnfdsp lyvggmpgkn nvaslrqapg qngtsfhgci rnlyinselq dfrkmpmqtg
     1321 ilpgcepchk kvcahgmcqp ssqsgftcec eegwmgplcd qrtndpclgn kcvhgtclpi
     1381 nafsysckcl eghggvlcde eedlfnpcqm ikckhgkcrl sgvgqpycec nsgftgdscd
     1441 reiscrgeri rdyyqkqqgy aacqttkkvs rlecrggcag gqccgplrsk rrkysfectd
     1501 gssfvdevek vvkcgcarca s
//
LOCUS       NP_031930                442 aa            linear   ROD 27-AUG-2025
DEFINITION  endothelin receptor type B isoform 1 precursor [Mus musculus].
ACCESSION   NP_031930
VERSION     NP_031930.1
DBSOURCE    REFSEQ: accession NM_007904.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Perry,C.H., Lavado,A., Thulabandu,V., Ramirez,C., Pare,J.,
            Dixit,R., Mishra,A., Yang,J., Yu,J. and Cao,X.
  TITLE     TEAD switches interacting partners along neural progenitor lineage
            progression to execute distinct functions
  JOURNAL   Genes Dev 39 (13-14), 849-867 (2025)
   PUBMED   40389325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Ramalingam,H., Alvarez,J., Flaten,A., Cobo-Stark,P., Foster,N.,
            Grilli,E., Lakhia,R., Aboudehen,K., Carroll,T. and Patel,V.
  TITLE     An RNA transmethylation pathway governs kidney nephrogenic
            potential
  JOURNAL   Nat Commun 16 (1), 4930 (2025)
   PUBMED   40436842
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 442)
  AUTHORS   McInnis,J.J., LeComte,M.D., Reed,L.F., Torsney,E.E., Del
            Rio-Guerra,R., Poynter,M.E. and Spees,J.L.
  TITLE     Microglial cell proliferation is regulated, in part, by reactive
            astrocyte ETBR signaling after ischemic stroke
  JOURNAL   Exp Neurol 385, 115125 (2025)
   PUBMED   39716588
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Tan,J., Duron,A., Sucov,H.M. and Makita,T.
  TITLE     Placode and neural crest origins of congenital deafness in mouse
            models of Waardenburg-Shah syndrome
  JOURNAL   iScience 28 (1), 111680 (2024)
   PUBMED   39868048
  REMARK    Erratum:[iScience. 2025 Apr 11;28(5):112400. doi:
            10.1016/j.isci.2025.112400. PMID: 40276772]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Osada,S., Mizuno,K., Saido,T.C., Suzuki,K., Kuroki,T. and Ohno,S.
  TITLE     A new member of the protein kinase C family, nPKC theta,
            predominantly expressed in skeletal muscle
  JOURNAL   Mol Cell Biol 12 (9), 3930-3938 (1992)
   PUBMED   1508194
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Russell,L.B., Hunsicker,P.R., Cacheiro,N.L. and Rinchik,E.M.
  TITLE     Genetic, cytogenetic, and molecular analyses of mutations induced
            by melphalan demonstrate high frequencies of heritable deletions
            and other rearrangements from exposure of postspermatogonial stages
            of the mouse
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 6182-6186 (1992)
   PUBMED   1352884
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Russell,L.B., Hunsicker,P.R. and Shelby,M.D.
  TITLE     Melphalan, a second chemical for which specific-locus mutation
            induction in the mouse is maximum in early spermatids
  JOURNAL   Mutat Res 282 (3), 151-158 (1992)
   PUBMED   1378547
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Mayer,T.C.
  TITLE     Enhancement of melanocyte development from piebald neural crest by
            a favorable tissue environment
  JOURNAL   Dev Biol 56 (2), 255-262 (1977)
   PUBMED   849800
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Womack,J.E., Davisson,M.T., Eicher,E.M. and Kendall,D.A.
  TITLE     Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10)
            on mouse chromosome 14
  JOURNAL   Biochem Genet 15 (3-4), 347-355 (1977)
   PUBMED   405970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154670.2 and AC110092.4.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor family. It encodes a receptor for endothelins, peptides
            that are involved in vasocontriction. The encoded protein activates
            a phosphatidylinositol-calcium second messenger system and is
            required for the development of enteric neurons and melanocytes.
            Gene disruption causes pigmentation anomalies, deafness, and
            abnormal dilation of the colon due to defects of neural
            crest-derived cells. Mutations in this gene are found in the
            piebald mouse, and mouse models of Hirschsprung's disease and
            Waardenburg syndrome type 4. Renal collecting duct-specific gene
            deletion causes sodium retention and hypertension. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085532.1, AK085165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 53.05 cM"
     Protein         1..442
                     /product="endothelin receptor type B isoform 1 precursor"
                     /note="piebald; endothelin B receptor; endothelin receptor
                     non-selective type"
                     /calculated_mol_wt=46902
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2677
     mat_peptide     27..442
                     /product="Endothelin receptor type B. /id=PRO_0000012730"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
                     /calculated_mol_wt=46902
     Region          50..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Region          102..397
                     /region_name="7tmA_ET-BR"
                     /note="endothelin B receptor, member of the class A family
                     of seven-transmembrane G protein-coupled receptors;
                     cd15976"
                     /db_xref="CDD:320642"
     Site            102..126
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          103..129
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320642"
     Region          136..162
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320642"
     Site            138..163
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            order(158,161..162,174..179,181..182,185,230,232..236,270,
                     273..275,277..279,281..282,336,339..340,342..343,346,
                     364..365,367..369,372,375..376)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320642"
     Region          174..204
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320642"
     Site            176..197
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          216..236
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320642"
     Site            219..243
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          270..295
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320642"
     Site            272..296
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Region          316..346
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320642"
     Site            325..350
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Site            363..389
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P48302.1)"
     Region          365..390
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320642"
     Site            419
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            439
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P28088; propagated from
                     UniProtKB/Swiss-Prot (P48302.1)"
     CDS             1..442
                     /gene="Ednrb"
                     /gene_synonym="ET-B; ET-BR; ETb; ETR-b; Sox10m1"
                     /coded_by="NM_007904.5:220..1548"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS27317.1"
                     /db_xref="GeneID:13618"
                     /db_xref="MGI:MGI:102720"
ORIGIN      
        1 mqspasrcgr alvalllacg flgvwgekrg fppaqatlsl lgtkevmtpp tktswtrgsn
       61 sslmrssapa evtkggrgag vpprsfpppc qrnieisktf kyintivscl vfvlgiigns
      121 tllriiyknk cmrngpnili aslalgdllh iiidipinty kllaedwpfg aemcklvpfi
      181 qkasvgitvl slcalsidry ravaswsrik gigvpkwtav eivliwvvsv vlavpeaigf
      241 dmitsdykgk plrvcmlnpf qktafmqfyk takdwwlfsf yfclplaita vfytlmtcem
      301 lrkksgmqia lndhlkqrre vaktvfclvl vfalcwlplh lsrilkltly dqsnphrcel
      361 lsfllvldyi ginmaslnsc inpialylvs krfkncfksc lccwcqtfee kqsleekqsc
      421 lkfkandhgy dnfrssnkys ss
//
LOCUS       NP_114087                855 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4-like isoform 2 [Mus musculus].
ACCESSION   NP_114087
VERSION     NP_114087.2
DBSOURCE    REFSEQ: accession NM_031881.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 855)
  AUTHORS   Zeng,Q., Guo,H., Tang,N., Renavikar,P.S., Karandikar,N.J.,
            Lovett-Racke,A.E., Racke,M.K., Yan,C., Tang,R., Sinha,S., Ghosh,K.,
            Ryal,J.P., Ouyang,S., Chen,M., Amari,F., Vincenzo,C., Pope,R.M.,
            Li,Y., Yang,H., Langdon,W.Y. and Zhang,J.
  TITLE     K27-linked RORgammat ubiquitination by Nedd4 potentiates
            Th17-mediated autoimmunity
  JOURNAL   J Biomed Sci 32 (1), 26 (2025)
   PUBMED   39972304
  REMARK    Erratum:[J Biomed Sci. 2025 Apr 16;32(1):42. doi:
            10.1186/s12929-025-01136-8. PMID: 40234865]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 855)
  AUTHORS   Liu,H., Wang,N., Yang,R., Luan,J., Cao,M., Zhai,C., Wang,S.,
            Wei,M., Wang,D., Qiao,J., Liu,Y., She,W., Guo,N., Liao,B. and
            Gou,X.
  TITLE     E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis
            by Inhibiting IL-6/GP130 Signaling Pathway
  JOURNAL   J Invest Dermatol 144 (11), 2453-2464 (2024)
   PUBMED   38580105
  REMARK    GeneRIF: E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin
            Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway.
REFERENCE   3  (residues 1 to 855)
  AUTHORS   Blackburn,D.M., Sahinyan,K., Hernandez-Corchado,A., Lazure,F.,
            Richard,V., Raco,L., Perron,G., Zahedi,R.P., Borchers,C.H.,
            Lepper,C., Kawabe,H., Jahani-Asl,A., Najafabadi,H.S. and
            Soleimani,V.D.
  TITLE     The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell
            quiescence by inhibiting their activation
  JOURNAL   iScience 27 (7), 110241 (2024)
   PUBMED   39015146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 855)
  AUTHORS   Han,F., Wu,S., Dong,Y., Liu,Y., Sun,B. and Chen,L.
  TITLE     Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by
            downregulating CaMKKbeta in diabetic kidney disease
  JOURNAL   J Transl Med 22 (1), 465 (2024)
   PUBMED   38755664
  REMARK    GeneRIF: Aberrant expression of NEDD4L disrupts mitochondrial
            homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 855)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 855)
  AUTHORS   Flasza,M., Gorman,P., Roylance,R., Canfield,A.E. and Baron,M.
  TITLE     Alternative splicing determines the domain structure of WWP1, a
            Nedd4 family protein
  JOURNAL   Biochem Biophys Res Commun 290 (1), 431-437 (2002)
   PUBMED   11779188
REFERENCE   7  (residues 1 to 855)
  AUTHORS   Debonneville,C., Flores,S.Y., Kamynina,E., Plant,P.J., Tauxe,C.,
            Thomas,M.A., Munster,C., Chraibi,A., Pratt,J.H., Horisberger,J.D.,
            Pearce,D., Loffing,J. and Staub,O.
  TITLE     Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+)
            channel cell surface expression
  JOURNAL   EMBO J 20 (24), 7052-7059 (2001)
   PUBMED   11742982
REFERENCE   8  (residues 1 to 855)
  AUTHORS   Harvey,K.F., Dinudom,A., Cook,D.I. and Kumar,S.
  TITLE     The Nedd4-like protein KIAA0439 is a potential regulator of the
            epithelial sodium channel
  JOURNAL   J Biol Chem 276 (11), 8597-8601 (2001)
   PUBMED   11244092
REFERENCE   9  (residues 1 to 855)
  AUTHORS   Kamynina,E., Debonneville,C., Bens,M., Vandewalle,A. and Staub,O.
  TITLE     A novel mouse Nedd4 protein suppresses the activity of the
            epithelial Na+ channel
  JOURNAL   FASEB J 15 (1), 204-214 (2001)
   PUBMED   11149908
REFERENCE   10 (residues 1 to 855)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102333.10, AC161175.5 and AC102288.11.
            
            On Feb 8, 2008 this sequence version replaced NP_114087.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF277232.1, BC071210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 37.57 cM"
     Protein         1..855
                     /product="E3 ubiquitin-protein ligase NEDD4-like isoform
                     2"
                     /EC_number="2.3.2.26"
                     /EC_number="2.3.2.36"
                     /note="E3 ubiquitin-protein ligase NEDD4-like; neural
                     precursor cell expressed, developmentally down-regulated
                     gene 4b; HECT-type E3 ubiquitin transferase NED4L"
                     /calculated_mol_wt=98325
     Region          <1..32
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          77..103
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          267..296
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          380..410
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(394,405)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          429..461
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(445,456)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(504,535,546,608,781,816..817,820..824,844,851)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          522..851
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(636,639..640,642..643,646,651,653,657..658,660,665,
                     670,687,691)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..855
                     /gene="Nedd4l"
                     /gene_synonym="1300012C07Rik; Nedd4-2; NEDD4.2; Nedd4b"
                     /coded_by="NM_031881.3:343..2910"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS29305.1"
                     /db_xref="GeneID:83814"
                     /db_xref="MGI:MGI:1933754"
ORIGIN      
        1 merpytfkdf llrprshksr vkgflrlkma ympknggqde enseqrddme hgwevvdsnd
       61 sasqhqeelp ppplppgwee kvdnlgrtyy vnhnnrstqw hrpslmdvss esdnnirqin
      121 qeaahrrfrs rrhisedlep easegggegp epwetiseem nmagdslsla lppppaspvs
      181 rtspqelsee vsrrlqitpd sngeqfssli qrepssrlrs csvtdtvaeq ahlpppstpt
      241 rrarsstvtg geestpsvay vhttpglpsg weerkdakgr tyyvnhnnrt ttwtrpimql
      301 aedgasgsat nsnnhlvepq irrprslssp tvtlsapleg akdspirrav kdtlsnpqsp
      361 qpspynspkp qhkvtqsflp pgwemriapn grpffidhnt ktttwedprl kfpvhmrska
      421 slnpndlgpl ppgweerihl dgrtfyidhn skitqwedpr lqnpaitgpa vpysrefkqk
      481 ydyfrkklkk padipnrfem klhrnnifee syrrimsvkr pdvlkarlwi efesekgldy
      541 ggvarewffl lskemfnpyy glfeysatdn ytlqinpnsg lcnedhlsyf tfigrvagla
      601 vfhgklldgf firpfykmml gkqitlndme svdseyynsl kwilendpte ldlmfcidee
      661 nfgqtyqvdl kpngseimvt nenkreyidl viqwrfvnrv qkqmnafleg ftellpidli
      721 kifdenelel lmcglgdvdv ndwrqhsiyk ngycpnhpvi qwfwkavllm daekrirllq
      781 fvtgtsrvpm ngfaelygsn gpqlftieqw gspeklprah tcfnrldlpp yetfedlrek
      841 llmavenaqg fegvd
//
LOCUS       NP_001413565            1037 aa            linear   ROD 27-AUG-2025
DEFINITION  ras GTPase-activating protein 1 isoform 2 [Mus musculus].
ACCESSION   NP_001413565
VERSION     NP_001413565.1
DBSOURCE    REFSEQ: accession NM_001426636.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1037)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (residues 1 to 1037)
  AUTHORS   Paul,M.E., Chen,D., Vish,K.J., Lartey,N.L., Hughes,E.,
            Freeman,Z.T., Saunders,T.L., Stiegler,A.L., King,P.D. and
            Boggon,T.J.
  TITLE     The C2 domain augments Ras GTPase-activating protein catalytic
            activity
  JOURNAL   Proc Natl Acad Sci U S A 122 (6), e2418433122 (2025)
   PUBMED   39899710
REFERENCE   3  (residues 1 to 1037)
  AUTHORS   Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
            Robinson,S.D.
  TITLE     A proteomics approach to isolating neuropilin-dependent alpha5
            integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
            integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells
  JOURNAL   Commun Biol 7 (1), 629 (2024)
   PUBMED   38789481
  REMARK    GeneRIF: A proteomics approach to isolating neuropilin-dependent
            alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
            alpha5 integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1037)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 1037)
  AUTHORS   Chen,D., Geng,X., Lapinski,P.E., Davis,M.J., Srinivasan,R.S. and
            King,P.D.
  TITLE     RASA1-driven cellular export of collagen IV is required for the
            development of lymphovenous and venous valves in mice
  JOURNAL   Development 147 (23) (2020)
   PUBMED   33144395
  REMARK    GeneRIF: RASA1-driven cellular export of collagen IV is required
            for the development of lymphovenous and venous valves in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1037)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   7  (residues 1 to 1037)
  AUTHORS   Eggen,A., Solinas-Toldo,S., Dietz,A.B., Womack,J.E., Stranzinger,G.
            and Fries,R.
  TITLE     RASA contains a polymorphic microsatellite and maps to bovine
            syntenic group U22 on chromosome 7q2.4-qter
  JOURNAL   Mamm Genome 3 (10), 559-563 (1992)
   PUBMED   1421763
REFERENCE   8  (residues 1 to 1037)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   9  (residues 1 to 1037)
  AUTHORS   Jenkins,E.P., Hsieh,C.L., Milatovich,A., Normington,K.,
            Berman,D.M., Francke,U. and Russell,D.W.
  TITLE     Characterization and chromosomal mapping of a human steroid 5
            alpha-reductase gene and pseudogene and mapping of the mouse
            homologue
  JOURNAL   Genomics 11 (4), 1102-1112 (1991)
   PUBMED   1686016
REFERENCE   10 (residues 1 to 1037)
  AUTHORS   Hsieh,C.L., Vogel,U.S., Dixon,R.A. and Francke,U.
  TITLE     Chromosome localization and cDNA sequence of murine and human genes
            for ras p21 GTPase activating protein (GAP)
  JOURNAL   Somat Cell Mol Genet 15 (6), 579-590 (1989)
   PUBMED   2574500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127316.3 and AC154271.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1432815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.05 cM"
     Protein         1..1037
                     /product="ras GTPase-activating protein 1 isoform 2"
                     /note="p120-rasGAP; GTPase-activating protein"
                     /calculated_mol_wt=115199
     Region          152..255
                     /region_name="SH2_Nterm_RasGAP"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10353"
                     /db_xref="CDD:198216"
     Site            order(179,198,220,222)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198216"
     Site            order(221,247)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198216"
     Region          272..329
                     /region_name="SH3_RasGAP"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; cd11788"
                     /db_xref="CDD:212722"
     Region          340..416
                     /region_name="SH2_Cterm_RasGAP"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10354"
                     /db_xref="CDD:198217"
     Site            order(348,367,388,390)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198217"
     Site            order(389,416)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198217"
     Region          479..566
                     /region_name="PH_RASA1"
                     /note="RAS p21 protein activator (GTPase activating
                     protein) 1 Pleckstrin homology (PH) domain; cd13260"
                     /db_xref="CDD:270080"
     Region          581..706
                     /region_name="C2_Ras_p21A1"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); cd08400"
                     /db_xref="CDD:176045"
     Region          704..1035
                     /region_name="RasGAP_p120GAP"
                     /note="Ras-GTPase Activating Domain of p120; cd05391"
                     /db_xref="CDD:213340"
     Site            order(739,775,777,779..780,782,785,789,884,892..893,
                     896..897,900,921,924..925,928,932,934,939..940)
                     /site_type="other"
                     /note="RAS interface [polypeptide binding]"
                     /db_xref="CDD:213340"
     CDS             1..1037
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /coded_by="NM_001426636.1:462..3575"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:218397"
                     /db_xref="MGI:MGI:97860"
ORIGIN      
        1 mmaaeagsee ggpatagpgg gaatgssays aacrvklpaa lpvaaapcpg ladadlvaal
       61 gggaasgsgf lgtgpvagvl ggaaltgsaa agvagaaaag pagdvaftkg tlslpaetlg
      121 pgggfpplpp ppqlpplgsg lgtvdegdsl dgpeyeeeev aipltapptn qwyhgkldrt
      181 iaeerlrqag ksgsylires drrpgsfvls flsqtnvvnh friiamcgdy yiggrrfssl
      241 sdligyyshv scllkgekll ypvappepve drrrvrailp ytkvpdtdei sflkgdmfiv
      301 hneledgwmw vtnlrtdeqg livedlveeg reedphegki wfhgkiskqe aynllmtvgq
      361 vcsflvrpsd ntpgdyslyf rtneniqrfk icptpnnqfm mggryynsig diidhyrkeq
      421 ivegyylkep vpmqdqgqvl ndtvdgkeiy ntirrktkda fyknivkkgy llkkgkgkrw
      481 knlyfilegs daqliyfese kratkpkgli dlsvcsvyvv hdslfgrpnc fqivvqhfse
      541 ehyifyfage tpeqaedwmk glqafcslrk sspgtsnkrl rqvsslvlhi eeahklpvkh
      601 ftnpycniyl nsvqvaktha regqnpvwse efvfddlppd inrfeitlsn ktkkskdpdi
      661 lfmrcqlsrl qkghatdewf llsshiplkg iepgslrvra rysmekimpe eeysefkeli
      721 lqkelhvvya lshvcgqdrt llasillkif lhekleslll ctlndreism edeattlfra
      781 ttlastlmeq ymkatatqfv hhalkdsilk imeskqscel spsklekned vntnlahlls
      841 ilselvekif maseilpptl ryiygclqks vqhkwptnnt mrtrvvsgfv flrlicpail
      901 nprmfniisd spspiaartl tlvaksvqnl anlvefgake pymegvnpfi ksnkhrmimf
      961 ldelgnvpel pdttehsrtd lsrdlaalhe icvahsdelr tlsnergvqq hvlkkllait
     1021 ellqqkqnqy tktndir
//
LOCUS       NP_001258735             131 aa            linear   ROD 27-AUG-2025
DEFINITION  agouti-related protein precursor [Mus musculus].
ACCESSION   NP_001258735
VERSION     NP_001258735.1
DBSOURCE    REFSEQ: accession NM_001271806.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 131)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 131)
  AUTHORS   Senol,E., Wang,M., Xin,Y., Jiao,Z., Mohammad,H., Yeo,X.Y., Si,T.,
            Young,D.M., Huang,H., Wang,Y., Li,Q., Jung,S.Y., Xu,X., Zhang,P.
            and Fu,Y.
  TITLE     Brain-wide input-output analysis of tuberal nucleus somatostatin
            neurons reveals hierarchical circuits for orchestrating feeding
            behavior
  JOURNAL   Nat Commun 16 (1), 5627 (2025)
   PUBMED   40593512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 131)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   4  (residues 1 to 131)
  AUTHORS   Park,B.S., Yang,H.R., Kang,H., Kim,K.K., Kim,Y.T., Yang,S. and
            Kim,J.G.
  TITLE     alpha2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons:
            Impact on Food Intake and Energy Expenditure
  JOURNAL   Int J Mol Sci 26 (8), 3590 (2025)
   PUBMED   40332078
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 131)
  AUTHORS   Ilnytska,O. and Argyropoulos,G.
  TITLE     The role of the Agouti-Related Protein in energy balance regulation
  JOURNAL   Cell Mol Life Sci 65 (17), 2721-2731 (2008)
   PUBMED   18470724
  REMARK    Review article
REFERENCE   6  (residues 1 to 131)
  AUTHORS   Mizuno,T.M. and Mobbs,C.V.
  TITLE     Hypothalamic agouti-related protein messenger ribonucleic acid is
            inhibited by leptin and stimulated by fasting
  JOURNAL   Endocrinology 140 (2), 814-817 (1999)
   PUBMED   9927310
REFERENCE   7  (residues 1 to 131)
  AUTHORS   Broberger,C., Johansen,J., Johansson,C., Schalling,M. and
            Hokfelt,T.
  TITLE     The neuropeptide Y/agouti gene-related protein (AGRP) brain
            circuitry in normal, anorectic, and monosodium glutamate-treated
            mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 15043-15048 (1998)
   PUBMED   9844012
REFERENCE   8  (residues 1 to 131)
  AUTHORS   Graham,M., Shutter,J.R., Sarmiento,U., Sarosi,I. and Stark,K.L.
  TITLE     Overexpression of Agrt leads to obesity in transgenic mice
  JOURNAL   Nat Genet 17 (3), 273-274 (1997)
   PUBMED   9354787
REFERENCE   9  (residues 1 to 131)
  AUTHORS   Ollmann,M.M., Wilson,B.D., Yang,Y.K., Kerns,J.A., Chen,Y., Gantz,I.
            and Barsh,G.S.
  TITLE     Antagonism of central melanocortin receptors in vitro and in vivo
            by agouti-related protein
  JOURNAL   Science 278 (5335), 135-138 (1997)
   PUBMED   9311920
  REMARK    Erratum:[Science 1998 Sep 11;281(5383):1615]
REFERENCE   10 (residues 1 to 131)
  AUTHORS   Shutter,J.R., Graham,M., Kinsey,A.C., Scully,S., Luthy,R. and
            Stark,K.L.
  TITLE     Hypothalamic expression of ART, a novel gene related to agouti, is
            up-regulated in obese and diabetic mutant mice
  JOURNAL   Genes Dev 11 (5), 593-602 (1997)
   PUBMED   9119224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151573.2, BC079902.1 and
            AK138796.1.
            
            Summary: This gene encodes a protein that regulates feeding
            behavior and plays a key role in the control of body weight. The
            encoded protein acts as an antagonist of melanocortin receptor
            signaling. Alternatively spliced transcript variants have been
            observed for this gene. [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (2) contains an alternate 5' exon,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF900927.1, CF900964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..131
                     /product="agouti-related protein precursor"
                     /note="agouti-related protein; orexigenic neuropeptide"
                     /calculated_mol_wt=12379
     Region          1..121
                     /region_name="Agouti"
                     /note="Agouti protein; smart00792"
                     /db_xref="CDD:197876"
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2071
     Site            81..82
                     /site_type="cleavage"
                     /note="Cleavage, by PCSK1.
                     /evidence=ECO:0000250|UniProtKB:O00253; propagated from
                     UniProtKB/Swiss-Prot (P56473.1)"
     mat_peptide     82..131
                     /product="Agouti-related protein. /id=PRO_0000001035"
                     /note="propagated from UniProtKB/Swiss-Prot (P56473.1)"
                     /calculated_mol_wt=5684
     Region          110..112
                     /region_name="Interaction with melanocortin receptors.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56473.1)"
     CDS             1..131
                     /gene="Agrp"
                     /gene_synonym="Agrt; Art"
                     /coded_by="NM_001271806.1:321..716"
                     /db_xref="CCDS:CCDS22605.1"
                     /db_xref="GeneID:11604"
                     /db_xref="MGI:MGI:892013"
ORIGIN      
        1 mltamllscv lllalpptlg vqmgvaplkg irrpdqalfp efpglslngl kkttadraee
       61 vllqkaeala evldpqnres rsprrcvrlh esclgqqvpc cdpcatcycr ffnafcycrk
      121 lgtatnlcsr t
//
LOCUS       NP_001104491             465 aa            linear   ROD 27-AUG-2025
DEFINITION  runt-related transcription factor 1 isoform 1 [Mus musculus].
ACCESSION   NP_001104491
VERSION     NP_001104491.1
DBSOURCE    REFSEQ: accession NM_001111021.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Dupont,S.M., Garcia-Moreno,A., O'Neil,E.V. and Capel,B.C.
  TITLE     KDM6B is a conserved activator at the top of the male sex
            determination pathway
  JOURNAL   Development 152 (12) (2025)
   PUBMED   40406982
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Higaki,K., Aiba,S., Shimoyama,T., Omatsu,Y. and Nagasawa,T.
  TITLE     Universal fibroblasts across tissues can differentiate into niche
            cells for hematopoietic stem cells
  JOURNAL   Cell Rep 44 (5), 115620 (2025)
   PUBMED   40315055
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   5  (residues 1 to 465)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Sun,W., Graves,B.J. and Speck,N.A.
  TITLE     Transactivation of the Moloney murine leukemia virus and T-cell
            receptor beta-chain enhancers by cbf and ets requires intact
            binding sites for both proteins
  JOURNAL   J Virol 69 (8), 4941-4949 (1995)
   PUBMED   7609063
REFERENCE   7  (residues 1 to 465)
  AUTHORS   Simeone,A., Daga,A. and Calabi,F.
  TITLE     Expression of runt in the mouse embryo
  JOURNAL   Dev Dyn 203 (1), 61-70 (1995)
   PUBMED   7647375
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Calabi,F., Rhodes,M., Williamson,P. and Boyd,Y.
  TITLE     Identification and chromosomal mapping of a third mouse runt-like
            locus
  JOURNAL   Genomics 26 (3), 607-610 (1995)
   PUBMED   7607689
REFERENCE   9  (residues 1 to 465)
  AUTHORS   Miyoshi,H., Shimizu,K., Kozu,T., Maseki,N., Kaneko,Y. and Ohki,M.
  TITLE     t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are
            clustered within a limited region of a single gene, AML1
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10431-10434 (1991)
   PUBMED   1720541
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Kania,M.A., Bonner,A.S., Duffy,J.B. and Gergen,J.P.
  TITLE     The Drosophila segmentation gene runt encodes a novel nuclear
            regulatory protein that is also expressed in the developing nervous
            system
  JOURNAL   Genes Dev 4 (10), 1701-1713 (1990)
   PUBMED   2249771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040240.1, AK137493.1, CT025774.19, AL672278.12 and BQ033862.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as AML1-C; PMID 11243869).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137493.1, AK145098.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 53.7 cM"
     Protein         1..465
                     /product="runt-related transcription factor 1 isoform 1"
                     /note="oncogene AML-1; acute myeloid leukemia 1 protein;
                     core-binding factor subunit alpha-2; SL3-3 enhancer factor
                     1 alpha B subunit; SL3/AKV core-binding factor alpha B
                     subunit; polyomavirus enhancer-binding protein 2 alpha B
                     subunit; core binding factor alpha 2; runt domain, alpha
                     subunit 2"
                     /calculated_mol_wt=50081
     Region          65..193
                     /region_name="Runt"
                     /note="Runt domain; pfam00853"
                     /db_xref="CDD:459963"
     Region          375..465
                     /region_name="RunxI"
                     /note="Runx inhibition domain; pfam08504"
                     /db_xref="CDD:430037"
     CDS             1..465
                     /gene="Runx1"
                     /gene_synonym="AML1; CBF-alpha-2; Cbfa2; Pebp2a2; Pebpa2b"
                     /coded_by="NM_001111021.2:200..1597"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49917.1"
                     /db_xref="GeneID:12394"
                     /db_xref="MGI:MGI:99852"
ORIGIN      
        1 masdsifesf psypqcfmrd astsrrftpp stalspgkms ealplgapdg gaalasklrs
       61 gdrsmvevla dhpgelvrtd spnflcsvlp thwrcnktlp iafkvvalgd vpdgtlvtvm
      121 agndenysae lrnataamkn qvarfndlrf vgrsgrgksf tltitvftnp pqvatyhrai
      181 kitvdgprep rrhrqklddq tkpgslsfse rlseleqlrr tamrvsphhp aptpnprasl
      241 nhstafnpqp qsqmqdarqi qpsppwsydq syqylgsits ssvhpatpis pgrasgmtsl
      301 saelssrlst apdltafgdp rqfptlpsis dprmhypgaf tysppvtsgi gigmsamssa
      361 sryhtylppp ypgssqaqag pfqtgspsyh lyygasagsy qfsmvggers pprilppctn
      421 astgaallnp slpsqsdvve tegshsnspt nmpparleea vwrpy
//
LOCUS       NP_001193312             333 aa            linear   ROD 27-AUG-2025
DEFINITION  mitochondrial antiviral-signaling protein isoform 2 [Mus musculus].
ACCESSION   NP_001193312
VERSION     NP_001193312.1
DBSOURCE    REFSEQ: accession NM_001206383.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Soliman,N., Nedelko,T., Mandracci,G., Enssle,S., Grass,V.,
            Fischer,J.C., Bassermann,F., Poeck,H., Kobold,S., El Khawanky,N.
            and Heidegger,S.
  TITLE     Targeting Intracellular Innate RNA-Sensing Systems Overcomes
            Resistance to CAR T-cell Therapy in Solid Tumors
  JOURNAL   Cancer Res 85 (14), 2679-2693 (2025)
   PUBMED   40305099
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Okazaki,T., Nozaki,K., Morimoto,N., Otobe,Y., Saito,R., Abe,S.,
            Okajima,M., Yoshitane,H., Hatta,T., Iemura,S.I., Natsume,T.,
            Kosako,H., Yamasaki,M., Inoue,S., Kondo,T., Koseki,H. and Gotoh,Y.
  TITLE     Membrane topology inversion of GGCX mediates cytoplasmic
            carboxylation for antiviral defense
  JOURNAL   Science 389 (6755), 84-91 (2025)
   PUBMED   40608933
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Paulenda,T., Echalar,B., Potuckova,L., Vachova,V., Kleverov,D.A.,
            Mehringer,J., Potekhina,E., Jacoby,A., Sen,D., Nelson,C.,
            Stegeman,R., Sukhov,V., Kemper,D., Lichti,C.F., Day,N.J., Zhang,T.,
            Husarcikova,K., Bambouskova,M., Fremont,D.H., Qian,W.J.,
            Djuranovic,S., Pavlovic-Djuranovic,S., Belousov,V.V., Krezel,A.M.
            and Artyomov,M.N.
  TITLE     Itaconate modulates immune responses via inhibition of
            peroxiredoxin 5
  JOURNAL   Nat Metab 7 (6), 1183-1203 (2025)
   PUBMED   40251412
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Kobayashi,M., Kobayashi,N., Deguchi,K., Omori,S. and Ichinohe,T.
  TITLE     SARS-CoV-2 infection primes cross-protective respiratory IgA in a
            MyD88- and MAVS-dependent manner
  JOURNAL   NPJ Vaccines 10 (1), 40 (2025)
   PUBMED   40016252
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Kumar,H., Kawai,T., Kato,H., Sato,S., Takahashi,K., Coban,C.,
            Yamamoto,M., Uematsu,S., Ishii,K.J., Takeuchi,O. and Akira,S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Sun,Q., Sun,L., Liu,H.H., Chen,X., Seth,R.B., Forman,J. and
            Chen,Z.J.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Meylan,E., Curran,J., Hofmann,K., Moradpour,D., Binder,M.,
            Bartenschlager,R. and Tschopp,J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Xu,L.G., Wang,Y.Y., Han,K.J., Li,L.Y., Zhai,Z. and Shu,H.B.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Seth,R.B., Sun,L., Ea,C.K. and Chen,Z.J.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808128.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. Variants 3
            and 4 encode the same isoform (2), which has a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.730832.1,
                                           SRR17253014.2900316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..333
                     /product="mitochondrial antiviral-signaling protein
                     isoform 2"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=34258
     CDS             1..333
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_001206383.1:459..1460"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 msggslipsp nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr
       61 talrtnllsg vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps
      121 prlvpvktms sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan
      181 tippernskq aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa
      241 csvdlaisps sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc
      301 assmpwakwl gatsallavf lavmlyrsrr laq
//
LOCUS       NP_001288159             221 aa            linear   ROD 27-AUG-2025
DEFINITION  ras-related protein Rab-27A [Mus musculus].
ACCESSION   NP_001288159 XP_006510844
VERSION     NP_001288159.1
DBSOURCE    REFSEQ: accession NM_001301230.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 221)
  AUTHORS   Chen,R., Powell,J.S., Shufesky,W.J., Bardhi,E., Sullivan,M.L.G.,
            Tkacheva,O.A., Camirand,G., Goncalves,Z., Stolz,D.B., Chalasani,G.,
            Catz,S.D., Watkins,S.C., Larregina,A.T. and Morelli,A.E.
  TITLE     Transplants foster B cell alloimmunity by relaying extracellular
            vesicles to follicular dendritic cells
  JOURNAL   Cell Rep 44 (6), 115832 (2025)
   PUBMED   40516053
REFERENCE   2  (residues 1 to 221)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 221)
  AUTHORS   Li,X., Qiao,F., Guo,J., Jiang,T., Lou,H., Li,H., Xie,G., Wu,H.,
            Wang,W., Pei,R., Liu,S., Ye,M., Li,J., Huang,S., Zhang,M., Ma,C.,
            Huang,Y., Xu,S., Li,X., Sun,X., Yu,J., Fok,K.L., Duan,S. and
            Chen,H.
  TITLE     In situ architecture of the intercellular organelle reservoir
            between epididymal epithelial cells by volume electron microscopy
  JOURNAL   Nat Commun 16 (1), 1664 (2025)
   PUBMED   39955273
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 221)
  AUTHORS   Gu,J., Chen,X., Luo,Z., Li,R., Xu,Q., Liu,M., Liu,X., Liu,Y.,
            Jiang,S., Zou,M., Ling,S., Liu,S. and Liu,N.
  TITLE     Cardiomyocyte-derived exosomes promote cardiomyocyte proliferation
            and neonatal heart regeneration
  JOURNAL   FASEB J 38 (22), e70186 (2024)
   PUBMED   39560071
REFERENCE   5  (residues 1 to 221)
  AUTHORS   Munafo,D.B., Johnson,J.L., Ellis,B.A., Rutschmann,S., Beutler,B.
            and Catz,S.D.
  TITLE     Rab27a is a key component of the secretory machinery of azurophilic
            granules in granulocytes
  JOURNAL   Biochem J 402 (2), 229-239 (2007)
   PUBMED   17090228
  REMARK    GeneRIF: Rab27a and JFC1/Slp1 permit myeloperoxidase release into
            the surrounding milieu and constitute key components of the
            secretory machinery of azurophilic granules in granulocytes
REFERENCE   6  (residues 1 to 221)
  AUTHORS   Barral,D.C., Ramalho,J.S., Anders,R., Hume,A.N., Knapton,H.J.,
            Tolmachova,T., Collinson,L.M., Goulding,D., Authi,K.S. and
            Seabra,M.C.
  TITLE     Functional redundancy of Rab27 proteins and the pathogenesis of
            Griscelli syndrome
  JOURNAL   J Clin Invest 110 (2), 247-257 (2002)
   PUBMED   12122117
  REMARK    GeneRIF: Rab27b is functionally redundant with Rab27a and the
            pathogenesis of Griscelli syndrome is determined by the relative
            expression of Rab27a and Rab27b in specialized cell types.
            Erratum:[J Clin Invest 2002 Oct;110(8):1213]
REFERENCE   7  (residues 1 to 221)
  AUTHORS   Wilson,S.M., Yip,R., Swing,D.A., O'Sullivan,T.N., Zhang,Y.,
            Novak,E.K., Swank,R.T., Russell,L.B., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A mutation in Rab27a causes the vesicle transport defects observed
            in ashen mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7933-7938 (2000)
   PUBMED   10859366
REFERENCE   8  (residues 1 to 221)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (residues 1 to 221)
  AUTHORS   Moore,K.J., Swing,D.A., Rinchik,E.M., Mucenski,M.L., Buchberg,A.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene dsu suppresses the coat-color
            phenotype of three pigment mutations that alter melanocyte
            morphology, d, ash and ln
  JOURNAL   Genetics 119 (4), 933-941 (1988)
   PUBMED   3410303
REFERENCE   10 (residues 1 to 221)
  AUTHORS   Langdon,W.Y., Theodore,T.S., Buckler,C.E., Stimpfling,J.H.,
            Martin,M.A. and Morse,H.C. 3rd.
  TITLE     Relationship between a retroviral germ line reintegration and a new
            mutation at the ashen locus in B10.F mice. Retroviral integration
            and an ashen mutation
  JOURNAL   Virology 133 (1), 183-190 (1984)
   PUBMED   6322428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ077071.1, BY151058.1,
            AK010373.1, AK008798.1, BE948607.1 and BP769437.1.
            
            On Jul 29, 2014 this sequence version replaced XP_006510844.1.
            
            Summary: The protein encoded by this gene is a member of the Rab
            family of proteins, which is the largest family within the Ras
            superfamily of GTPases. This gene product is thought to regulate
            vesicular transport, together with its specific effectors.
            Mutations in this gene cause several defects, including actin-based
            melanosome transport defects and immunodeficiency. Mutations in the
            human ortholog of this gene are associated with Griscelli syndrome
            type 2. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008173.1, ERR3363660.2883278.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     Protein         1..221
                     /product="ras-related protein Rab-27A"
                     /EC_number="3.6.5.2"
                     /note="ashen"
                     /calculated_mol_wt=24886
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P51159; propagated from
                     UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51159; propagated from
                     UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Region          6..185
                     /region_name="Rab27A"
                     /note="Rab GTPase family 27a (Rab27a); cd04127"
                     /db_xref="CDD:206700"
     Site            6..11
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206700"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206700"
     Site            order(19..24,134,136,164..165)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206700"
     Site            order(24..34,39..40)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206700"
     Site            order(34,39..47)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206700"
     Region          38..46
                     /region_name="Effector region. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ERI2.1)"
     Site            order(39,43..50,67,69)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206700"
     Site            order(42,44..46,71,73,80..81,84,88,90..93)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206700"
     Site            order(42..43,45,73..74,81,83,85..87)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            42..46
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206700"
     Site            69..73
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206700"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206700"
     Site            order(77,79..89)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206700"
     Site            80..85
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206700"
     Site            88..92
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206700"
     Site            97..102
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206700"
     Site            120..130
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206700"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206700"
     Site            163..165
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206700"
     Site            179..185
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206700"
     Site            221
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9ERI2.1)"
     CDS             1..221
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /coded_by="NM_001301230.1:374..1039"
                     /db_xref="CCDS:CCDS23335.1"
                     /db_xref="GeneID:11891"
                     /db_xref="MGI:MGI:1861441"
ORIGIN      
        1 msdgdydyli kflalgdsgv gktsvlyqyt dgkfnskfit tvgidfrekr vvyrangpdg
       61 avgrgqrihl qlwdtagqer frslttaffr damgflllfd ltneqsflnv rnwisqlqmh
      121 aycenpdivl cgnksdledq ravkeeeare laekygipyf etsaangtni shaiemlldl
      181 imkrmercvd kswipegvvr snghtsadql seekekglcg c
//
LOCUS       NP_001263394            4389 aa            linear   ROD 27-AUG-2025
DEFINITION  intermembrane lipid transfer protein VPS13D isoform 2 [Mus
            musculus].
ACCESSION   NP_001263394
VERSION     NP_001263394.1
DBSOURCE    REFSEQ: accession NM_001276465.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 4389)
  AUTHORS   Miao,G., Fortier,T.M., Liu,H., Schafer,D.P., Fitzgerald,K.A.,
            Mao,J. and Baehrecke,E.H.
  TITLE     Microglia promote inflammatory cell death upon neuronal
            mitochondrial impairment during neurodegeneration
  JOURNAL   Nat Struct Mol Biol (2025) In press
   PUBMED   40563011
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 4389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 4389)
  AUTHORS   Montillot,C., Skutunova,E., Ayushma, Dubied,M., Lahmar,A.,
            Nguyen,S., Peerally,B., Prin,F., Duffourd,Y., Thauvin-Robinet,C.,
            Duplomb,L., Wang,H., Ansar,M., Faivre,L., Navarro,N., Minocha,S.,
            Collins,S.C. and Yalcin,B.
  TITLE     Characterization of Vps13b-mutant mice reveals neuroanatomical and
            behavioral phenotypes with females less affected
  JOURNAL   Neurobiol Dis 185, 106259 (2023)
   PUBMED   37573958
REFERENCE   4  (residues 1 to 4389)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627087.11, AI789476.1, AK172952.1 and AL606909.12.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in an internal coding exon, compared to isoform 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. There are no full-length mouse
            transcripts supporting this exon combination; inferred from partial
            mouse transcripts AI789476.1, AK172952.1, and human transcript
            AJ608774.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4389
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.17 cM"
     Protein         1..4389
                     /product="intermembrane lipid transfer protein VPS13D
                     isoform 2"
                     /note="vacuolar protein sorting 13 D"
                     /calculated_mol_wt=490769
     Region          1..>1270
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          138..349
                     /region_name="VPS13"
                     /note="Vacuolar sorting-associated protein 13, N-terminal;
                     pfam16908"
                     /db_xref="CDD:465309"
     Region          <2466..>3102
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2642..2677
                     /region_name="UBA_VP13D"
                     /note="UBA domain found in vacuolar protein
                     sorting-associated protein 13D (VP13D) and similar
                     proteins; cd14306"
                     /db_xref="CDD:270491"
     Region          3276..3559
                     /region_name="SHR-BD"
                     /note="SHR-binding domain of vacuolar-sorting associated
                     protein 13; pfam06650"
                     /db_xref="CDD:461974"
     Region          3614..3774
                     /region_name="beta-trefoil_Ricin_VPS13D"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in vacuolar protein sorting-associated protein 13D
                     (VPS13D) and similar proteins; cd23453"
                     /db_xref="CDD:467331"
     Site            order(3626..3629,3635,3637,3640,3645..3646)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Site            order(3683..3686,3699,3701,3704,3710..3711)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Site            order(3730..3733,3745,3747,3750,3766..3767)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Region          <3837..4299
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     CDS             1..4389
                     /gene="Vps13d"
                     /coded_by="NM_001276465.1:162..13331"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:230895"
                     /db_xref="MGI:MGI:2448530"
ORIGIN      
        1 mleglvawvl ntylgkyvnn lntdqlsval lkgavelenl plkkdalkel elpfevkagl
       61 igkvtlqipf yrphvdpwvi sisglhvigg pekiqdfnde kekllererk kallqaleer
      121 wkserrqqkg epywysvtas vvtrivenie lkiqdvhlrf edgvtnpsrp fafgiciknv
      181 smqnaanepv qklmrkkrld vaefsiywdv nctllgdlpq aelqeamars mesrshhyil
      241 epvcasallk rncskeplrs rhspriecdi qletiplkls qlqyrqimaf lkelerkerq
      301 lkfrkwkpkv avskncreww yfalnanlye ireqrkcwtw dfllhrarda vfytdryfnk
      361 lkggvlsadd keemcrieee qsfeelkilr elvhdrfykq eelaeslrep qfdspgtspg
      421 dpdgsggsgm lqylqswfpg wggwygqqsp egkvveglta eshehwtpee ilgteeffdp
      481 tadascmnty tkrdhvfakl nvqlqrgtvt llhkeqgtah anesafmqle fsdvkllaes
      541 lprrnsslll vrlgglflrd lategtmfpl lvfpnpqkev grvsqsfglq tasedrsdqy
      601 saadpdnpvf emlyernpvh shferrlhvs trplniiynp qaikkvadff ykgkvhtsgf
      661 gyqselelrv aeaarrqydk lkvqtkaeir qtldrllvgd fieeskrwtv rldisapqvi
      721 fpddftfknp vlvvvdlgrm lltntqedsr rksgdgsase enqfsddeyk tplatppstp
      781 ppetsssnge ktppfsgvef seeqlqahlm stqmyerysl tfmdlqvmvg rvrdnwkrvq
      841 didvgpthvv ekfnvhlqle rrliytsdpk ypgavlsgnl pdlkihined kisalkncfa
      901 llttpetkps dtqirekifp qegprgslqd svmnltqsiv mleqhtrevl vesqlllaef
      961 kvncmqlgve ssgryisvlk vfgtnahfvk rpydaevslt vhglllvdtm qtygadfdll
     1021 mashknlsfd iptgslrdsr aqspvsgpnv afqtdvttln dqsatsvsle kiltkeqesl
     1081 ikleyqfvss ecpsmnldst lqvislqvnn ldiilnpeti veligflqks fpkekddvsp
     1141 qplmtdlers iveqgtiqst yeqntevave ihrlnllllr tvgmadgerh grkiatasig
     1201 gtkvnvsmgs sfdmngslgc lqlmdltqen vksqyvvsig nsvgyenivs digyfesvfv
     1261 rmedaaltea lsftfaeksk qecflnlkma slhynhsakf lkeltlsmde leenfrsmlk
     1321 saatkvttvl atktaeysem vslfetpkkt repfvleene iygfglpspr sdtvklilni
     1381 niespvvsip rrpgspellv ghlgqifiqn fvagdddsrs drlqveikdi klyslnctql
     1441 agrdnagpev nrtfcppsgl asvnsqeeah ftrhdffesl hrgqafhiln nttiqfklek
     1501 ipiereselt fslspdelgt ssimkiegkf vnpvqvvlak hvyeqvlqtm dnlvysedln
     1561 kfaasaptsp cpnsplpqls scgepcvekk englfshssf sstsqkslsv keakaftqiq
     1621 anfciselqv qlsgdltlga qglvslkfqd fevefskdhp qtlsiqialr sllmedllek
     1681 npdskykslm vsrgapkpss laqkeylsqs cpsvssveyp dmprslpshm eeapnvfqly
     1741 qrpistcrkk pkeaqdksyp qtpppspsvd epnmlvgksk fddslvhini flvdkkhpef
     1801 sssygrinrs idvdfncldv litlqtwvvi ldffgigsta dnhamkvppe gllqnvkaes
     1861 sasmesehqe pvnskldlkv hslslvlska tselakanvs klmahmemie gdlalqgsig
     1921 slslsdltph gdfyrerftt sgeealifqt fkygqpdpll qrehdirvsl qmasvqyvht
     1981 qrfqaevvaf iqhftqlqdi lgrqraaieg qtvrdqaqrc srilldieag apvllipess
     2041 rsnnlivanl gklkvknkfl fagfpgtfsl qdkesvpsas pagtpkhsmr kmtttedpkg
     2101 pqvqglfmmp pagvglgslk sdfvpsasik qrgqqavppv sqsssspedh vclldcivvd
     2161 lqdmdifaae rhpregskas ehssgdlifp syfvrqtggs lltepcrlkl qvernldkei
     2221 shtvadisvh gslssvhcsl dlckyklirg llennlgepi edfmrpydlq dprihtvlsg
     2281 evytcmcfli dmvnvslelk dpkgkegtgs larfdfkkck llyesfsnqt ksinlvshsm
     2341 mafdtrysgq kpshgmtnvf ncifqpskss satqgsiqie lhfrstkdss cftvvlnnlr
     2401 vflifdwlll vhdflhtpsd ikkqnvtpar hrnassesav vpktvksgvv tkrsslpvsn
     2461 erhlevkvnv tgtefvvved vscfdtnaii lkgttvltyk prfvdrpfsg slfgievfsc
     2521 rlgneqdtal sivdpvqiqv elvgnssyqn ssglmdafns edfppileiq lqaldirlsy
     2581 ndvqlflaia ksipeqasaa apdssalevd siscslpgas rigedvregs rhtldpvlel
     2641 qlarlqelgf smddcrkall vcqgqlkkaa swlfknaepl kslslvssss rdnpgtmpap
     2701 risgvevkae svcicfiddc mdcdvplael tfsrlnflqh irtnpegfah ftlsgdyynr
     2761 alsgwepfie pwpcsvswqq qassrlhppr lkleakakrr ldinitsvli dqyistkesw
     2821 ladyckedke tesaktedwm gssvdppcfg qslplvylrt rstasltnle hqiyarevkt
     2881 pkrrqpfvpf alrnhtgctl wfatltttpt raalshsgsp gvvpegngaf lddahnvsew
     2941 revltgeeip fefeargklr hrhthdlrih qlqvrvngwe qvspvsvdkv gtffryaapd
     3001 knsssstigs pssrtniihp qvyfsslppv rvvfavtmeg sarkvitvrs alivknrlet
     3061 pmelrldsps apdkpvvlpa impgdsfavp lhltswrlqa rpkgmgvffc kvpihwtnvv
     3121 ktaevssskr echsmdteks rffrfcvaik kenypdymps nifsdsakqi frqpghtiyl
     3181 lptvvicnll pceldfyvkg mpingtlkpg keaalptadt sqnielgvsl enfplckell
     3241 ippgtqnymv rmrlydvnrr qlnltiriac raegslkifi sapywlinkt glplifrqdn
     3301 aktdaagqfe ehelarslsp llfcyadkeq pnlctmrigr gihpegmpgw cqgfsldggs
     3361 gvralkviqq gnrpgliyni gidvkkgrgr yidtcmvifa prylldnkss hklafaqref
     3421 argqgtanpn gyistlpgss vvfhwprndy dqllcvrlmd vpnciwsggf evnknnsfhi
     3481 nmrdtlgkcf flrveitlrg atyrisfsdt dqlpppfrid nfskvpvvft qhgvaeprlr
     3541 tevkpmmsld yawdeptlpp fitltvkgag sseincnmnd fqnnrqlyye nfiyiaatyt
     3601 fsglqegkgr pvashkaitc aelvldvspk tqrvilkkke pgkrsqlwrm tgtgmlaheg
     3661 savphnpnkp satrsiegsa ildiaglaav tdnryeplml rkpdrrrstt qtwsfhegkl
     3721 tcglhglvvq akgglsglfd gaevvlgpds smellgpvpp eqqfanqkmr pgsgmlsirv
     3781 ipdgptralq itdfcqrkse rssyeveelp vteqelqklr npdthqelev lvrleggvgv
     3841 slinkvpeel vfasltgini hytqlaashm lelsiqdvqv dnqligttqp fmlyvtplsn
     3901 enevietgpa vqvnavkfps ksaltniykh lmvtaqrftv qieeklllkl lsffgydqae
     3961 sevekydeni hektaeqggt ptryyfenlk isipqiklsv ftsnklpldl kalkstlgfp
     4021 lirfedavin ldpftrvhpy etkefiindi lkhfqeells qaarilgsvd flgnpmglln
     4081 dvsegvtgli kygnvgglir nvthgvsnsa akfagtlsdg lgktmdnrhq sereyiryha
     4141 atsgehlvag ihglahgiig gltsvitstv egvkteggvs gfisglgkgl vgtvtkpvag
     4201 aldfasetaq avrdtatlsg prtqaqrvrk prcctgpqgl lprysesqae gqeqlfkltd
     4261 niqdeffiav enidsycvli sskavyflks gdyvdreaif levkyddlyh clvskdhgkv
     4321 yvqvtkkaan sssgvsipgp shqkpmvhvk sevlavklsq einyakslyy eqqlmlrlse
     4381 nqeqlelds
//
LOCUS       NP_001398583             766 aa            linear   ROD 27-AUG-2025
DEFINITION  autotaxin isoform 8 [Mus musculus].
ACCESSION   NP_001398583 XP_036015150
VERSION     NP_001398583.1
DBSOURCE    REFSEQ: accession NM_001411654.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 766)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 766)
  AUTHORS   Dacheux,M.A., Norman,D.D., Shin,Y., Tigyi,G.J. and Lee,S.C.
  TITLE     Deleting autotaxin in LysM+ myeloid cells impairs innate tumor
            immunity in models of metastatic melanoma
  JOURNAL   iScience 27 (10), 110971 (2024)
   PUBMED   39398245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 766)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   4  (residues 1 to 766)
  AUTHORS   Petersen-Cherubini,C.L., Liu,Y., Deffenbaugh,J.L., Murphy,S.P.,
            Xin,M., Rau,C.N., Yang,Y. and Lovett-Racke,A.E.
  TITLE     Dysregulated autotaxin expression by T cells in multiple sclerosis
  JOURNAL   J Neuroimmunol 387, 578282 (2024)
   PUBMED   38183947
  REMARK    GeneRIF: Dysregulated autotaxin expression by T cells in multiple
            sclerosis.
REFERENCE   5  (residues 1 to 766)
  AUTHORS   Giganti,A., Rodriguez,M., Fould,B., Moulharat,N., Coge,F.,
            Chomarat,P., Galizzi,J.P., Valet,P., Saulnier-Blache,J.S.,
            Boutin,J.A. and Ferry,G.
  TITLE     Murine and human autotaxin alpha, beta, and gamma isoforms: gene
            organization, tissue distribution, and biochemical characterization
  JOURNAL   J Biol Chem 283 (12), 7776-7789 (2008)
   PUBMED   18175805
  REMARK    GeneRIF: Murine and human autotaxin alpha, beta, and gamma
            isoforms: gene organization, tissue distribution, and biochemical
            characterization.
REFERENCE   6  (residues 1 to 766)
  AUTHORS   Koike,S., Keino-Masu,K., Ohto,T. and Masu,M.
  TITLE     The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions
            as a signal peptide
  JOURNAL   Genes Cells 11 (2), 133-142 (2006)
   PUBMED   16436050
REFERENCE   7  (residues 1 to 766)
  AUTHORS   Jansen,S., Stefan,C., Creemers,J.W., Waelkens,E., Van Eynde,A.,
            Stalmans,W. and Bollen,M.
  TITLE     Proteolytic maturation and activation of autotaxin (NPP2), a
            secreted metastasis-enhancing lysophospholipase D
  JOURNAL   J Cell Sci 118 (Pt 14), 3081-3089 (2005)
   PUBMED   15985467
REFERENCE   8  (residues 1 to 766)
  AUTHORS   Bachner,D., Ahrens,M., Betat,N., Schroder,D. and Gross,G.
  TITLE     Developmental expression analysis of murine autotaxin (ATX)
  JOURNAL   Mech Dev 84 (1-2), 121-125 (1999)
   PUBMED   10473125
REFERENCE   9  (residues 1 to 766)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (residues 1 to 766)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123644.8.
            
            On Aug 30, 2022 this sequence version replaced XP_036015150.1.
            
            Summary: This gene encodes a member of the phosphodiesterase and
            nucleotide pyrophosphatase family of bifunctional enzymes that
            hydrolize phosphodiester bonds of various nucleotides. The encoded
            protein undergoes proteolytic processing to generate a mature
            protein with lysophospholipase D activity, catalyzing the cleavage
            of the choline group from lysophosphatidylcholine to produce
            lysophosphatidic acid. This gene is expressed in numerous tissues
            and participates in neural development, obesity, inflammation and
            oncogenesis. A complete lack of the encoded protein in mice results
            in aberrant vascular and neuronal development leading to embryonic
            lethality. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (8) uses an alternate in-frame
            splice site, lacks an in-frame exon, and lacks a frame-shifting
            exon in the central coding region, compared to variant 1. The
            encoded isoform (8) is shorter and has a distinct C-terminus,
            compared to isoform 1. This isoform (8) may undergo proteolytic
            processing similar to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.217826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.6 cM"
     Protein         1..766
                     /product="autotaxin isoform 8"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; autotaxin; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2"
                     /calculated_mol_wt=87105
     Site            53
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM,
                     ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO,
                     ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ,
                     ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV,
                     ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX,
                     ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH; propagated
                     from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          56..97
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          98..141
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          126..128
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          144..501
                     /region_name="Phosphodiesterase domain.
                     /evidence=ECO:0000305|PubMed:21240269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          165..477
                     /region_name="Phosphodiest"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; pfam01663"
                     /db_xref="CDD:396300"
     Site            order(171,208..209,230,311,315,358..359,474)
                     /site_type="active"
                     /db_xref="CDD:293742"
     Site            order(171,208..209,230,311,315,359,474)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293742"
     Site            410
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639,
                     ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN,
                     ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP,
                     ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR,
                     ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW,
                     ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY,
                     ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH,
                     ECO:0007744|PDB:5LIA; propagated from UniProtKB/Swiss-Prot
                     (Q9R1E6.3)"
     Site            499..501
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:293742"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639,
                     ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN,
                     ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP,
                     ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR,
                     ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW,
                     ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY,
                     ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH,
                     ECO:0007744|PDB:5LIA; propagated from UniProtKB/Swiss-Prot
                     (Q9R1E6.3)"
     Region          610..>708
                     /region_name="NUC"
                     /note="DNA/RNA non-specific endonuclease; prokaryotic and
                     eukaryotic double- and single-stranded DNA and RNA
                     endonucleases also present in phosphodiesterases. They
                     exists as monomers and homodimers; cl00089"
                     /db_xref="CDD:469610"
     CDS             1..766
                     /gene="Enpp2"
                     /gene_synonym="ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha;
                     Pdnp2"
                     /coded_by="NM_001411654.1:58..2358"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /db_xref="GeneID:18606"
                     /db_xref="MGI:MGI:1321390"
ORIGIN      
        1 marqgcfgsy qvislftfai gvnlclgfta srikraewde gpptvlsdsp wtntsgsckg
       61 rcfelqevgp pdcrcdnlck sysscchdfd elclktargw ectkdrcgev rneenachcs
      121 edclsrgdcc tnyqvvckge shwvdddcee irvpecpagf vrppliifsv dgfrasymkk
      181 gskvmpniek lrscgthapy mrpvyptktf pnlytlatgl ypeshgivgn smydpvfdat
      241 fhlrgrekfn hrwwggqplw itatkqgvra gtffwsvsip herriltilq wlslpdnerp
      301 svyafyseqp dfsghkygpf gpemtnplre idktvgqlmd glkqlklhrc vnvifvgdhg
      361 medvtcdrte flsnyltnvd ditlvpgtlg rirpkipnnl kydpkaiian ltckkpdqhf
      421 kpymkqhlpk rlhyannrri edlhllverr whvarkpldv ykkpsgkcff qgdhgfdnkv
      481 nsmqtvfvgy gptfkyrtkv ppfenielyn vmcdllglkp apnngthgsl nhllrtntfr
      541 ptlpeevsrp nypgimylqs dfdlgctcdd knkleelnkr lhtkgsteer hllygrpavl
      601 yrtsydilyh tdfesgysei flmplwtsyt iskqaevssi pehltncvrp dvrvspgfsq
      661 nclaykndkq msygflfppy lssspeakyd aflvtnmvpm ypafkrmwka alflslpttt
      721 asspaawtsl slqtsvmvls lcllssfltd ltmmravivp rmsrsg
//
LOCUS       NP_112735                449 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon-induced protein 44-like [Mus musculus].
ACCESSION   NP_112735
VERSION     NP_112735.1
DBSOURCE    REFSEQ: accession NM_031367.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Zhang,C., Chen,S., Wang,Z., Zhang,J., Yu,W., Wang,Y., Si,W.,
            Zhang,Y., Zhang,Y. and Liang,T.
  TITLE     Exploring the mechanism of intestinal bacterial translocation after
            severe acute pancreatitis: the role of Toll-like receptor 5
  JOURNAL   Gut Microbes 17 (1), 2489768 (2025)
   PUBMED   40243695
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Busse,D.C., Habgood-Coote,D., Clare,S., Brandt,C., Bassano,I.,
            Kaforou,M., Herberg,J., Levin,M., Eleouet,J.F., Kellam,P. and
            Tregoning,J.S.
  TITLE     Interferon-Induced Protein 44 and Interferon-Induced Protein
            44-Like Restrict Replication of Respiratory Syncytial Virus
  JOURNAL   J Virol 94 (18), e00297-20 (2020)
   PUBMED   32611756
  REMARK    GeneRIF: Interferon-Induced Protein 44 and Interferon-Induced
            Protein 44-Like Restrict Replication of Respiratory Syncytial
            Virus.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 449)
  AUTHORS   Wiltshire,S.A., Leiva-Torres,G.A. and Vidal,S.M.
  TITLE     Quantitative trait locus analysis, pathway analysis, and consomic
            mapping show genetic variants of Tnni3k, Fpgt, or H28 control
            susceptibility to viral myocarditis
  JOURNAL   J Immunol 186 (11), 6398-6405 (2011)
   PUBMED   21525387
  REMARK    GeneRIF: Data identified Tnni3k, Fpgt and H28 as likely likely
            candidates for Vms1.
REFERENCE   5  (residues 1 to 449)
  AUTHORS   Malarkannan,S., Horng,T., Eden,P., Gonzalez,F., Shih,P.,
            Brouwenstijn,N., Klinge,H., Christianson,G., Roopenian,D. and
            Shastri,N.
  TITLE     Differences that matter: major cytotoxic T cell-stimulating minor
            histocompatibility antigens
  JOURNAL   Immunity 13 (3), 333-344 (2000)
   PUBMED   11021531
REFERENCE   6  (residues 1 to 449)
  AUTHORS   Paul,P.R. and Elliott,R.W.
  TITLE     Analysis of the mouse Amy locus in recombinant inbred mouse strains
  JOURNAL   Biochem Genet 25 (7-8), 569-579 (1987)
   PUBMED   2451911
REFERENCE   7  (residues 1 to 449)
  AUTHORS   Mobraaten,L.E., Bunker,H.P., DeMaeyer-Guignard,J., DeMaeyer,E. and
            Bailey,D.W.
  TITLE     Location of histocompatibility and interferon loci on chromosome 3
            of the mouse
  JOURNAL   J Hered 75 (3), 233-234 (1984)
   PUBMED   6203959
REFERENCE   8  (residues 1 to 449)
  AUTHORS   Elliott,R.W.
  TITLE     Use of two-dimensional electrophoresis to identify and map new
            mouse genes
  JOURNAL   Genetics 91 (2), 295-308 (1979)
   PUBMED   447069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF336221.1.
            
            Summary: This gene encodes a minor histocompatibility antigen that
            is involved in tissue graft rejection and is polymorphic in
            different mouse strains. The 5' region of this gene, including the
            translational start codon and the first 293 amino acids, is absent
            from the C57BL/6J genome. The encoded antigen is not thought to be
            expressed in C57BL/6J. [provided by RefSeq, Mar 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF336221.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /strain="BALB/c x BALB.B F1"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 76.94 cM"
     Protein         1..449
                     /product="interferon-induced protein 44-like"
                     /note="H28c minor histocompatibility antigen 1;
                     histocompatibility 28"
                     /calculated_mol_wt=49929
     CDS             1..449
                     /gene="Ifi44l"
                     /gene_synonym="H-28; H28; H28-1; NS1178"
                     /coded_by="NM_031367.1:85..1434"
                     /db_xref="GeneID:15061"
                     /db_xref="MGI:MGI:95975"
ORIGIN      
        1 mkvtarltwi eekilekllg nasltllyqs sahkncvsem tqkyslqgst mtvfhlekdv
       61 vvgvfilenf prlvsekpct cawfslkrnn ssgisalfln tkvivdseel iifsldglsl
      121 svtplrgftl alndtvmngl elnlghgflp veceifrvdg ikknpsfikk mvtaeqhrgk
      181 llsalraykp ykdlvsegsy slggpsrlre srafstqwks afqghltrqa hcggsdessi
      241 tkqyrvysik dgksgetlpf mlcdsmglee geeaglcidd iphilqgcvp dryqfnpcep
      301 mkpkhsphaa spplkdrihc vafvlhinsv ntlsdkmvak lkkirkdvvd cgigyvallt
      361 nveeydevld dsfanmtetv tslsqvqnvq kwlnipiani lmvsnyaser rlepmkdilv
      421 faalrqmlra addaledlll edtgnlapf
//
LOCUS       NP_573555                305 aa            linear   ROD 27-AUG-2025
DEFINITION  GS homeobox 2 [Mus musculus].
ACCESSION   NP_573555
VERSION     NP_573555.1
DBSOURCE    REFSEQ: accession NM_133256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 305)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 305)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 305)
  AUTHORS   Gao,Y., Sun,M., Fu,T., Wang,Z., Jiang,X., Yang,L., Liang,X.G.,
            Liu,G., Tian,Y., Yang,F., Li,J., Li,Z., Li,X., You,Y., Ding,C.,
            Wang,Y., Ma,T., Zhang,Z., Xu,Z., Chen,B. and Yang,Z.
  TITLE     NOTCH, ERK, and SHH signaling respectively control the fate
            determination of cortical glia and olfactory bulb interneurons
  JOURNAL   Proc Natl Acad Sci U S A 122 (9), e2416757122 (2025)
   PUBMED   39999176
REFERENCE   4  (residues 1 to 305)
  AUTHORS   Tweedie,L., Riccetti,M.R., Cain,B., Qin,S., Salomone,J., Webb,J.A.,
            Riesenberg,A., Ehrman,L.A., Waclaw,R.R., Kovall,R.A., Gebelein,B.
            and Campbell,K.
  TITLE     Modelling a pathological GSX2 variant that selectively alters DNA
            binding reveals hypomorphic mouse brain defects
  JOURNAL   Dis Model Mech 18 (2) (2025)
   PUBMED   39882631
REFERENCE   5  (residues 1 to 305)
  AUTHORS   Liang,X.G., Hoang,K., Meyerink,B.L., Kc,P., Paraiso,K., Wang,L.,
            Jones,I.R., Zhang,Y., Katzman,S., Finn,T.S., Tsyporin,J., Qu,F.,
            Chen,Z., Visel,A., Kriegstein,A., Shen,Y., Pilaz,L.J. and Chen,B.
  TITLE     A conserved molecular logic for neurogenesis to gliogenesis switch
            in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 121 (20), e2321711121 (2024)
   PUBMED   38713624
REFERENCE   6  (residues 1 to 305)
  AUTHORS   Nagle,D.L., Kozak,C.A., Mano,H., Chapman,V.M. and Bucan,M.
  TITLE     Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh
            mutation on mouse chromosome 5 is associated with an inversion
  JOURNAL   Hum Mol Genet 4 (11), 2073-2079 (1995)
   PUBMED   8589683
REFERENCE   7  (residues 1 to 305)
  AUTHORS   Sommers,C.L., Huang,K., Shores,E.W., Grinberg,A., Charlick,D.A.,
            Kozak,C.A. and Love,P.E.
  TITLE     Murine txk: a protein tyrosine kinase gene regulated by T cell
            activation
  JOURNAL   Oncogene 11 (2), 245-251 (1995)
   PUBMED   7542761
REFERENCE   8  (residues 1 to 305)
  AUTHORS   Valerius,M.T., Li,H., Stock,J.L., Weinstein,M., Kaur,S., Singh,G.
            and Potter,S.S.
  TITLE     Gsh-1: a novel murine homeobox gene expressed in the central
            nervous system
  JOURNAL   Dev Dyn 203 (3), 337-351 (1995)
   PUBMED   8589431
REFERENCE   9  (residues 1 to 305)
  AUTHORS   Hsieh-Li,H.M., Witte,D.P., Szucsik,J.C., Weinstein,M., Li,H. and
            Potter,S.S.
  TITLE     Gsh-2, a murine homeobox gene expressed in the developing brain
  JOURNAL   Mech Dev 50 (2-3), 177-186 (1995)
   PUBMED   7619729
REFERENCE   10 (residues 1 to 305)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161192.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S79041.1, SRR7345562.4878329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     Protein         1..305
                     /product="GS homeobox 2"
                     /note="homeobox protein GSH-2; genomic screened homeo box
                     2; genetic-screened homeobox 2"
                     /calculated_mol_wt=32036
     Region          115..151
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P31316.2)"
     Region          204..260
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          259..305
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P31316.2)"
     CDS             1..305
                     /gene="Gsx2"
                     /gene_synonym="Gsh-2; Gsh2"
                     /coded_by="NM_133256.2:161..1078"
                     /db_xref="CCDS:CCDS19350.1"
                     /db_xref="GeneID:14843"
                     /db_xref="MGI:MGI:95843"
ORIGIN      
        1 msrsfyvdsl iikdssrpap slpeshpgpd ffiplgmpsp lvmsvsgpgc psrksgafcv
       61 cplcvtshlh ssrppagagg gatgtagaav agggvaggtg alpllksqfs papgdaqfcp
      121 rvshahhhhh ppqhhhhhhq pqqpgsaaaa aaaaaaaaaa aaalghpqhh apvcaattyn
      181 msdprrfhcl smggsdtsqv pngkrmrtaf tstqlleler efssnmylsr lrrieiatyl
      241 nlsekqvkiw fqnrrvkhkk egkgasrnnh tsckcvgsqa hyarsededs lspasanedk
      301 eispl
//
LOCUS       NP_001278157            1525 aa            linear   ROD 27-AUG-2025
DEFINITION  slit homolog 2 protein isoform b precursor [Mus musculus].
ACCESSION   NP_001278157 XP_006503880
VERSION     NP_001278157.1
DBSOURCE    REFSEQ: accession NM_001291228.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1525)
  AUTHORS   Santos-Cantador,J., Siguero-Alvarez,M. and de la Pompa,J.L.
  TITLE     Patterning Defects in Mice with Defective Ventricular Wall
            Maturation and Cardiomyopathy
  JOURNAL   J Cardiovasc Dev Dis 12 (6), 224 (2025)
   PUBMED   40558659
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1525)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1525)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1525)
  AUTHORS   Rama,N., Dubrac,A., Mathivet,T., Ni Charthaigh,R.A., Genet,G.,
            Cristofaro,B., Pibouin-Fragner,L., Ma,L., Eichmann,A. and
            Chedotal,A.
  TITLE     Slit2 signaling through Robo1 and Robo2 is required for retinal
            neovascularization
  JOURNAL   Nat Med 21 (5), 483-491 (2015)
   PUBMED   25894826
  REMARK    GeneRIF: Slit2 signaling through Robo1 and Robo2 has a role in
            retinal neovascularization
REFERENCE   5  (residues 1 to 1525)
  AUTHORS   Grieshammer,U., Le,Ma., Plump,A.S., Wang,F., Tessier-Lavigne,M. and
            Martin,G.R.
  TITLE     SLIT2-mediated ROBO2 signaling restricts kidney induction to a
            single site
  JOURNAL   Dev Cell 6 (5), 709-717 (2004)
   PUBMED   15130495
  REMARK    GeneRIF: Mutants lacking SLIT2 develop supernumerary ureteric buds
            that remain inappropriately connected to the nephric duct; the
            SLIT2 signal is transduced in the nephrogenic mesenchyme.
REFERENCE   6  (residues 1 to 1525)
  AUTHORS   Bagri,A., Marin,O., Plump,A.S., Mak,J., Pleasure,S.J.,
            Rubenstein,J.L. and Tessier-Lavigne,M.
  TITLE     Slit proteins prevent midline crossing and determine the
            dorsoventral position of major axonal pathways in the mammalian
            forebrain
  JOURNAL   Neuron 33 (2), 233-248 (2002)
   PUBMED   11804571
REFERENCE   7  (residues 1 to 1525)
  AUTHORS   Plump,A.S., Erskine,L., Sabatier,C., Brose,K., Epstein,C.J.,
            Goodman,C.S., Mason,C.A. and Tessier-Lavigne,M.
  TITLE     Slit1 and Slit2 cooperate to prevent premature midline crossing of
            retinal axons in the mouse visual system
  JOURNAL   Neuron 33 (2), 219-232 (2002)
   PUBMED   11804570
REFERENCE   8  (residues 1 to 1525)
  AUTHORS   Li,H.S., Chen,J.H., Wu,W., Fagaly,T., Zhou,L., Yuan,W., Dupuis,S.,
            Jiang,Z.H., Nash,W., Gick,C., Ornitz,D.M., Wu,J.Y. and Rao,Y.
  TITLE     Vertebrate slit, a secreted ligand for the transmembrane protein
            roundabout, is a repellent for olfactory bulb axons
  JOURNAL   Cell 96 (6), 807-818 (1999)
   PUBMED   10102269
REFERENCE   9  (residues 1 to 1525)
  AUTHORS   Hassoun,H., Hanada,T., Lutchman,M., Sahr,K.E., Palek,J., Hanspal,M.
            and Chishti,A.H.
  TITLE     Complete deficiency of glycophorin A in red blood cells from mice
            with targeted inactivation of the band 3 (AE1) gene
  JOURNAL   Blood 91 (6), 2146-2151 (1998)
   PUBMED   9490702
REFERENCE   10 (residues 1 to 1525)
  AUTHORS   Maekawa,T.L., Takahashi,T.A., Fujihara,M., Urushibara,N.,
            Kadowaki-Kikuchi,E., Nishikawa,M., Ikebuchi,K., Asano,S., Ozawa,K.
            and Sekiguchi,S.
  TITLE     A novel gene (drad-1) expressed in hematopoiesis-supporting stromal
            cell lines, ST2, PA6 and A54 preadipocytes: use of mRNA
            differential display
  JOURNAL   Stem Cells 15 (5), 334-339 (1997)
   PUBMED   9323794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053182.1, AC113542.13,
            AC157351.11, AC101004.6, AW556809.1 and BE944330.1.
            
            On Mar 29, 2014 this sequence version replaced XP_006503880.1.
            
            Summary: The protein encoded by this gene is a member of the Slit
            family of secreted glycoproteins, which function as ligands for the
            Robo family of immunoglobulin receptors. Slit proteins play highly
            conserved roles in axon guidance and neuronal migration and may
            also have functions during other cell migration processes including
            leukocyte migration. In mammals, members of the slit family are
            characterized by an N-terminal signal peptide, four leucine-rich
            repeats, nine epidermal growth factor repeats, and a C-terminal
            cysteine knot. Mice deficient for this gene exhibit abnormal axonal
            projections in the embryonic forebrain and develop supernumerary
            uretic buds that maintain improper connections to the nephric duct.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks alternate in-frame exons
            in the 5' and central coding regions compared to variant 1. It
            encodes isoform b, which is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220505.1, BC145488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 26.05 cM"
     Protein         1..1525
                     /product="slit homolog 2 protein isoform b precursor"
                     /note="slit homolog 2 protein; neurogenic extracellular
                     slit protein; downregulated during adipocyte
                     differentiation-1"
                     /calculated_mol_wt=166706
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=2598
     Region          27..58
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          38..56
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <56..>211
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          56..77
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          57..80
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          80..101
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          81..104
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          104..125
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          128..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          152..173
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          153..176
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          176..197
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          177..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..>260
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Site            186
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          201..329
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <287..>456
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          305..326
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          329..350
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          330..353
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          353..374
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          354..374
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          377..398
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          378..401
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          401..422
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          402..423
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          426..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <511..>662
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          520..555
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          530..551
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          555..576
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          556..579
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            560
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          579..600
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          580..603
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          603..624
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          604..627
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            619
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          627..648
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          628..649
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          633..>709
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          652..743
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <732..>857
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          744..774
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          751..773
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          774..795
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          775..798
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            790
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            795
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          798..819
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          799..822
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          822..843
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          823..844
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          828..>1009
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          994..1030
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(994,997,1011)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1005
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1006
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1015
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Region          1034..1069
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1072..1108
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(1072,1075,1089)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            1117..1118
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     mat_peptide     1118..1525
                     /product="Slit homolog 2 protein C-product.
                     /evidence=ECO:0000250. /id=PRO_0000007730"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1B9.2)"
                     /calculated_mol_wt=44591
     Region          1179..1312
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Site            1179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1262
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     Site            1296
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1B9.2)"
     CDS             1..1525
                     /gene="Slit2"
                     /gene_synonym="b2b1200.1Clo; Drad-1; E030015M03Rik;
                     E130320P19Rik; mKIAA4141; Slil3; slit-2"
                     /coded_by="NM_001291228.2:1886..6463"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS71588.1"
                     /db_xref="GeneID:20563"
                     /db_xref="MGI:MGI:1315205"
ORIGIN      
        1 msgigwqtls lslglvlsil nkvapqacpa qcscsgstvd chglalrsvp rniprnterl
       61 dlngnnitri tkidfaglrh lrvlqlmenr istiergafq dlkelerlrl nrnnlqlfpe
      121 llflgtakly rldlsenqiq aiprkafrga vdiknlqldy nqisciedga fralrdlevl
      181 tlnnnnitrl svasfnhmpk lrtfrlhsnn lycdchlawl sdwlrqrprv glytqcmgps
      241 hlrghnvaev qkrefvcsde eeghqsfmap scsvlhcpaa ctcsnnivdc rgkglteipt
      301 nlpetiteir leqnsirvip pgafspykkl rrldlsnnqi selapdafqg lrslnslvly
      361 gnkitelpks lfeglfslql lllnankinc lrvdafqdlh nlnllslydn klqtvakgtf
      421 salraiqtmh laqnpficdc hlkwladylh tnpietsgar ctsprrlank rigqikskkf
      481 rcsgtedyrs klsgdcfadl acpekcrceg ttvdcsnqrl nkipdhipqy taelrlnnne
      541 ftvleatgif kklpqlrkin fsnnkitdie egafegasgv neilltsnrl envqhkmfkg
      601 leslktlmlr snriscvgnd sfiglgsvrl lslydnqitt vapgafdslh slstlnllan
      661 pfncnchlaw lgewlrrkri vtgnprcqkp yflkeipiqd vaiqdftcdd gnddnscspl
      721 srcpsectcl dtvvrcsnkg lkvlpkgipk dvtelyldgn qftlvpkels nykhltlidl
      781 snnristlsn qsfsnmtqll tlilsynrlr cipprtfdgl kslrllslhg ndisvvpega
      841 fndlsalshl aiganplycd cnmqwlsdwv kseykepgia rcagpgemad klllttpskk
      901 ftcqgpvdit iqakcnpcls npckndgtcn ndpvdfyrct cpygfkgqdc dvpihacisn
      961 pckhggtchl kegenagfwc tcadgfegen cevniddced ndcennstcv dginnytclc
     1021 ppeytgelce ekldfcaqdl npcqhdskci ltpkgfkcdc tpgyigehcd idfddcqdnk
     1081 ckngahctda vngytcvcpe gysglfcefs ppmvlprtsp cdnfdcqnga qciirinepi
     1141 cqclpgylge kceklvsvnf vnkesylqip sakvrpqtni tlqiatdeds gillykgdkd
     1201 hiavelyrgr vrasydtgsh pasaiysvet indgnfhive lltldsslsl svdggspkvi
     1261 tnlskqstln fdsplyvggm pgknnvaslr qapgqngtsf hgcirnlyin selqdfrkmp
     1321 mqtgilpgce pchkkvcahg mcqpssqsgf tceceegwmg plcdqrtndp clgnkcvhgt
     1381 clpinafsys ckcleghggv lcdeeedlfn pcqmikckhg kcrlsgvgqp ycecnsgftg
     1441 dscdreiscr gerirdyyqk qqgyaacqtt kkvsrlecrg gcaggqccgp lrskrrkysf
     1501 ectdgssfvd evekvvkcgc arcas
//
LOCUS       NP_032346                424 aa            linear   ROD 27-AUG-2025
DEFINITION  interferon regulatory factor 8 [Mus musculus].
ACCESSION   NP_032346
VERSION     NP_032346.1
DBSOURCE    REFSEQ: accession NM_008320.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 424)
  AUTHORS   Shimizu,K., Sanpei,A., Nakazato,H., Shinga,J., Ueda,S., Liu,Y.,
            Iyoda,T., Yamasaki,S., Nakabayashi,J. and Fujii,S.I.
  TITLE     Distinct TAM subset with cross-dressing capability determines the
            bifurcation of tumor immunity
  JOURNAL   Cell Rep 44 (6), 115800 (2025)
   PUBMED   40489329
REFERENCE   2  (residues 1 to 424)
  AUTHORS   Polmann,L., Grimm,J.C., Roth,J. and Barczyk-Kahlert,K.
  TITLE     Interferon regulatory factor 8 induces intrinsic functional changes
            in mature neutrophils
  JOURNAL   J Leukoc Biol 117 (6) (2025)
   PUBMED   40457627
REFERENCE   3  (residues 1 to 424)
  AUTHORS   Tadepalli,S., Clements,D.R., Raquer-McKay,H.M., Ludtke,A.,
            Saravanan,S., Seong,D., Vitek,L., Richards,C.M., Carette,J.E.,
            Mack,M., Gottfried-Blackmore,A., Graves,E.E. and Idoyaga,J.
  TITLE     CD301b+ monocyte-derived dendritic cells mediate resistance to
            radiotherapy
  JOURNAL   J Exp Med 222 (6) (2025)
   PUBMED   40146036
REFERENCE   4  (residues 1 to 424)
  AUTHORS   Saeki,K., Pan,R., Lee,E., Kurotaki,D. and Ozato,K.
  TITLE     IRF8 defines the epigenetic landscape in postnatal microglia,
            thereby directing their transcriptome programs
  JOURNAL   Nat Immunol 25 (10), 1928-1942 (2024)
   PUBMED   39313544
REFERENCE   5  (residues 1 to 424)
  AUTHORS   Xiang,M., Wang,L., Guo,S., Lu,Y.Y., Lei,H., Jiang,D.S., Zhang,Y.,
            Liu,Y., Zhou,Y., Zhang,X.D. and Li,H.
  TITLE     Interferon regulatory factor 8 protects against cerebral
            ischaemic-reperfusion injury
  JOURNAL   J Neurochem 129 (6), 988-1001 (2014)
   PUBMED   24528256
  REMARK    GeneRIF: we found that the transcriptional factor IRF8 plays a
            protective role in the cerebral ischaemic-reperfusion injury by
            attenuating neuronal apoptosis
REFERENCE   6  (residues 1 to 424)
  AUTHORS   Scharton-Kersten,T., Contursi,C., Masumi,A., Sher,A. and Ozato,K.
  TITLE     Interferon consensus sequence binding protein-deficient mice
            display impaired resistance to intracellular infection due to a
            primary defect in interleukin 12 p40 induction
  JOURNAL   J Exp Med 186 (9), 1523-1534 (1997)
   PUBMED   9348310
REFERENCE   7  (residues 1 to 424)
  AUTHORS   Fehr,T., Schoedon,G., Odermatt,B., Holtschke,T., Schneemann,M.,
            Bachmann,M.F., Mak,T.W., Horak,I. and Zinkernagel,R.M.
  TITLE     Crucial role of interferon consensus sequence binding protein, but
            neither of interferon regulatory factor 1 nor of nitric oxide
            synthesis for protection against murine listeriosis
  JOURNAL   J Exp Med 185 (5), 921-931 (1997)
   PUBMED   9120398
REFERENCE   8  (residues 1 to 424)
  AUTHORS   Holtschke,T., Lohler,J., Kanno,Y., Fehr,T., Giese,N.,
            Rosenbauer,F., Lou,J., Knobeloch,K.P., Gabriele,L., Waring,J.F.,
            Bachmann,M.F., Zinkernagel,R.M., Morse,H.C. 3rd, Ozato,K. and
            Horak,I.
  TITLE     Immunodeficiency and chronic myelogenous leukemia-like syndrome in
            mice with a targeted mutation of the ICSBP gene
  JOURNAL   Cell 87 (2), 307-317 (1996)
   PUBMED   8861914
REFERENCE   9  (residues 1 to 424)
  AUTHORS   Kanno,Y., Kozak,C.A., Schindler,C., Driggers,P.H., Ennist,D.L.,
            Gleason,S.L., Darnell,J.E. Jr. and Ozato,K.
  TITLE     The genomic structure of the murine ICSBP gene reveals the presence
            of the gamma interferon-responsive element, to which an ISGF3 alpha
            subunit (or similar) molecule binds
  JOURNAL   Mol Cell Biol 13 (7), 3951-3963 (1993)
   PUBMED   8321202
REFERENCE   10 (residues 1 to 424)
  AUTHORS   Driggers,P.H., Ennist,D.L., Gleason,S.L., Mak,W.H., Marks,M.S.,
            Levi,B.Z., Flanagan,J.R., Appella,E. and Ozato,K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK150370.1, AK151324.1,
            AK018533.1 and BF662476.1.
            
            Summary: The protein encoded by this gene is a transcription factor
            that belongs to the interferon regulatory factor family. Proteins
            belonging to this family have a DNA binding domain at the amino
            terminus that contains five well-conserved tryptophan-rich repeats.
            This domain recognizes DNA sequences similar to the
            interferon-stimulated response element. The protein encoded by this
            gene promotes or suppresses lineage-specific genes to regulate the
            differentation of lymphoid and myeloid lineage cells. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005450.1, AK036488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.05 cM"
     Protein         1..424
                     /product="interferon regulatory factor 8"
                     /note="interferon consensus sequence binding protein 1;
                     interferon consensus sequence-binding protein"
                     /calculated_mol_wt=48106
     Region          9..113
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(42,81,83..84,87)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            order(86..87,89,92)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          202..379
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:463076"
     CDS             1..424
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1; IRF-8; Myls"
                     /coded_by="NM_008320.4:54..1328"
                     /db_xref="CCDS:CCDS22721.1"
                     /db_xref="GeneID:15900"
                     /db_xref="MGI:MGI:96395"
ORIGIN      
        1 mcdrnggrrl rqwlieqids smypgliwen dektmfripw khagkqdynq evdasifkaw
       61 avfkgkfkeg dkaepatwkt rlrcalnksp dfeevtdrsq ldisepykvy rivpeeeqkc
      121 klgvapagcm sevpemecgr seieelikep svdeymgmtk rspsppeacr sqilpdwwvq
      181 qpsaglplvt gyaaydthhs afsqmvisfy yggklvgqat ttclegcrls lsqpglpkly
      241 gpdglepvcf ptadtipser qrqvtrklfg hlergvllhs nrkgvfvkrl cqgrvfcsgn
      301 avvckgrpnk lerdevvqvf dtnqfirelq qfyatqsrlp dsrvvlcfge efpdtvplrs
      361 klilvqveql yarqlveeag kscgagslmp aleepqpdqa frmfpdicts hqrpffrenq
      421 qitv
//
LOCUS       NP_001298070             540 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-12 receptor subunit beta-2 isoform 2 [Mus musculus].
ACCESSION   NP_001298070 XP_011239528
VERSION     NP_001298070.1
DBSOURCE    REFSEQ: accession NM_001311141.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 540)
  AUTHORS   Schneeberger,S., Kim,S.J., Geesdorf,M.N., Friebel,E., Eede,P.,
            Jendrach,M., Boltengagen,A., Braeuning,C., Ruhwedel,T.,
            Hulsmeier,A.J., Gimber,N., Foerster,M., Obst,J., Andreadou,M.,
            Mundt,S., Schmoranzer,J., Prokop,S., Kessler,W., Kuhlmann,T.,
            Mobius,W., Nave,K.A., Hornemann,T., Becher,B., Edgar,J.M.,
            Karaiskos,N., Kocks,C., Rajewsky,N. and Heppner,F.L.
  TITLE     Interleukin-12 signaling drives Alzheimer's disease pathology
            through disrupting neuronal and oligodendrocyte homeostasis
  JOURNAL   Nat Aging 5 (4), 622-641 (2025)
   PUBMED   40082619
REFERENCE   2  (residues 1 to 540)
  AUTHORS   Krstanovic,F., Mihalic,A., Rashidi,A.S., Sitnik,K.M., Ruzsics,Z.,
            Cicin-Sain,L., Verjans,G.M.G.M., Jonjic,S. and Brizic,I.
  TITLE     Neuron-restricted cytomegalovirus latency in the central nervous
            system regulated by CD4+ T-cells and IFN-gamma
  JOURNAL   J Neuroinflammation 22 (1), 95 (2025)
   PUBMED   40158177
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 540)
  AUTHORS   Solaymani-Mohammadi,S.
  TITLE     The IL-21/IL-21R signaling axis regulates CD4+ T-cell
            responsiveness to IL-12 to promote bacterial-induced colitis
  JOURNAL   J Leukoc Biol 116 (4), 726-737 (2024)
   PUBMED   38498592
REFERENCE   4  (residues 1 to 540)
  AUTHORS   Elsner,R.A., Smita,S. and Shlomchik,M.J.
  TITLE     IL-12 induces a B cell-intrinsic IL-12/IFNgamma feed-forward loop
            promoting extrafollicular B cell responses
  JOURNAL   Nat Immunol 25 (7), 1283-1295 (2024)
   PUBMED   38862796
REFERENCE   5  (residues 1 to 540)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 540)
  AUTHORS   Wu,C., Wang,X., Gadina,M., O'Shea,J.J., Presky,D.H. and Magram,J.
  TITLE     IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective
            in IL-12-mediated signaling despite the presence of high affinity
            IL-12 binding sites
  JOURNAL   J Immunol 165 (11), 6221-6228 (2000)
   PUBMED   11086056
REFERENCE   7  (residues 1 to 540)
  AUTHORS   Galbiati,F., Rogge,L. and Adorini,L.
  TITLE     IL-12 receptor regulation in IL-12-deficient BALB/c and C57BL/6
            mice
  JOURNAL   Eur J Immunol 30 (1), 29-37 (2000)
   PUBMED   10602024
REFERENCE   8  (residues 1 to 540)
  AUTHORS   Himmelrich,H., Parra-Lopez,C., Tacchini-Cottier,F., Louis,J.A. and
            Launois,P.
  TITLE     The IL-4 rapidly produced in BALB/c mice after infection with
            Leishmania major down-regulates IL-12 receptor beta 2-chain
            expression on CD4+ T cells resulting in a state of unresponsiveness
            to IL-12
  JOURNAL   J Immunol 161 (11), 6156-6163 (1998)
   PUBMED   9834101
REFERENCE   9  (residues 1 to 540)
  AUTHORS   Szabo,S.J., Dighe,A.S., Gubler,U. and Murphy,K.M.
  TITLE     Regulation of the interleukin (IL)-12R beta 2 subunit expression in
            developing T helper 1 (Th1) and Th2 cells
  JOURNAL   J Exp Med 185 (5), 817-824 (1997)
   PUBMED   9120387
REFERENCE   10 (residues 1 to 540)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130822.3 and BC137745.1.
            
            On Jul 24, 2015 this sequence version replaced XP_011239528.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and therefore, differs in the 5' UTR and 5' coding region,
            compared to variant 1. These differences cause translation
            initiation at an alternate start codon and result in an isoform (2)
            with a shorter and distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040072.1, SRR13861859.6310707.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.81 cM"
     Protein         1..540
                     /product="interleukin-12 receptor subunit beta-2 isoform
                     2"
                     /note="interleukin-12 receptor subunit beta-2; IL-12R
                     subunit beta-2; IL-12 receptor subunit beta-2; interferon
                     response to microorganisms"
                     /calculated_mol_wt=61159
     Region          104..192
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          202..296
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(287..288,290..291)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..540
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /coded_by="NM_001311141.1:93..1715"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS80543.1"
                     /db_xref="GeneID:16162"
                     /db_xref="MGI:MGI:1270861"
ORIGIN      
        1 mepvgildiw ymkqdidydr qqislfwksl npseargkil hyqvtlqevt kkttlqnttr
       61 htswtrvipr tgawtasvsa anskgasapt hinivdlcgt gllaphqvsa ksenmdnilv
      121 twqppkkads avreyivewr alqpgsitkf pphwlrippd nmsaliseni kpyicyeirv
      181 halsesqggc ssirgdskhk apvsgphita itekkerlfi swthipfpeq rgcilhyriy
      241 wkerdstaqp elceiqyrrs qnshpisslq prvtyvlwmt avtaagespq gnerefcpqg
      301 kanwkafvis siciaiitvg tfsiryfrqk aftllstlkp qwysrtipdp anstwvkkyp
      361 ileekiqlpt dnllmawptp eepepliihe vlyhmipvvr qpyyfkrgqg fqgystskqd
      421 amyianpqat gtltaetrql vnlykvlesr dpdsklanlt spltvtpvny lpshegylps
      481 niedlsphea dptdsfdleh qhislsifas sslrplifgg erltldrlkm gydslmsnea
//
LOCUS       NP_001396744             746 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 1 [Mus musculus].
ACCESSION   NP_001396744
VERSION     NP_001396744.1
DBSOURCE    REFSEQ: accession NM_001409815.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 746)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 746)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 746)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 746)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 746)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 746)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 746)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 746)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 746)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 746)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.475515.1,
                                           SRR13422600.2134745.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164135,
                                           SAMN01164139 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..746
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     1"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85161
     Region          1..340
                     /region_name="Interaction with DNMT1, DNMT3A and DNMT3B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          329..522
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          340..426
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            367
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            487
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          559..590
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          609..728
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(613,615..618,620,624,627,629,679..680,683,703,719)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(621..624,641,648,651..652,655,659,662..668,685..689,
                     697,724,726..727)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..689,726)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(623..624,657..658,661,663,665,678,685..688)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(641,648,651..652,655,659,664,666..668,697,724,
                     726..728)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..746
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409815.1:242..2482"
                     /note="isoform 1 is encoded by transcript variant 8"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhpfh
      301 atpntykrkn tetaldnkpc gpqcyqhleg akefaaalta eriktppkrp ggrrrgrlpn
      361 nssrpstpti svleskdtds dreagtetgg enndkeeeek kdetssssea nsrcqtpikm
      421 kpnieppenv ewsgaeasmf rvligtyydn fcaiarligt ktcrqvyefr vkessiiapv
      481 ptedvdtppr kkkrkhrlwa ahcrkiqlkk dgssnhvyny qpcdhprqpc dsscpcviaq
      541 nfcekfcqcs secqnrfpgc rckaqcntkq cpcylavrec dpdlcltcga adhwdsknvs
      601 ckncsiqrgs kkhlllapsd vagwgifikd pvqknefise ycgeiisqde adrrgkvydk
      661 ymcsflfnln ndfvvdatrk gnkirfanhs vnpncyakvm mvngdhrigi fakraiqtge
      721 elffdyrysq adalkyvgie remeip
//
LOCUS       NP_848757                960 aa            linear   ROD 27-AUG-2025
DEFINITION  anoctamin-1 isoform 1 [Mus musculus].
ACCESSION   NP_848757
VERSION     NP_848757.5
DBSOURCE    REFSEQ: accession NM_178642.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 960)
  AUTHORS   Chakraborty,S., Wenzlitschke,N., Anderson,M.J., Eraso,A.,
            Baudic,M., Thompson,J.J., Evans,A.A., Shatford-Adams,L.M.,
            Chari,R., Awasthi,P., Dale,R.K., Lewandoski,M., Petros,T.J. and
            Rocha,P.P.
  TITLE     Deletion of a single CTCF motif at the boundary of a chromatin
            domain with three FGF genes disrupts gene expression and embryonic
            development
  JOURNAL   Dev Cell 60 (13), 1838-1853 (2025)
   PUBMED   40015278
REFERENCE   2  (residues 1 to 960)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   3  (residues 1 to 960)
  AUTHORS   Penrod,S., Tang,X., Moon,C., Whitsett,J.A., Naren,A.P. and Huang,Y.
  TITLE     EMC3 is critical for CFTR function and calcium mobilization in the
            mouse intestinal epithelium
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 328 (1), G72-G82 (2025)
   PUBMED   39641142
REFERENCE   4  (residues 1 to 960)
  AUTHORS   Sun,Z., Shan,X., Fan,C., Liu,L., Li,S., Wang,J., Zhou,N., Zhu,M.
            and Chen,H.
  TITLE     TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity
  JOURNAL   Stem Cells 42 (10), 902-913 (2024)
   PUBMED   39097775
  REMARK    GeneRIF: TMEM16A regulates satellite cell-mediated skeletal muscle
            regeneration by ensuring a moderate level of caspase 3 activity.
REFERENCE   5  (residues 1 to 960)
  AUTHORS   Raghavan,S., Brishti,M.A., Bernardelli,A., Mata-Daboin,A.,
            Jaggar,J.H. and Leo,M.D.
  TITLE     Extracellular glucose and dysfunctional insulin receptor signaling
            independently upregulate arterial smooth muscle TMEM16A expression
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1237-C1247 (2024)
   PUBMED   38581667
  REMARK    GeneRIF: Extracellular glucose and dysfunctional insulin receptor
            signaling independently upregulate arterial smooth muscle TMEM16A
            expression.
REFERENCE   6  (residues 1 to 960)
  AUTHORS   Yang,Y.D., Cho,H., Koo,J.Y., Tak,M.H., Cho,Y., Shim,W.S.,
            Park,S.P., Lee,J., Lee,B., Kim,B.M., Raouf,R., Shin,Y.K. and Oh,U.
  TITLE     TMEM16A confers receptor-activated calcium-dependent chloride
            conductance
  JOURNAL   Nature 455 (7217), 1210-1215 (2008)
   PUBMED   18724360
  REMARK    GeneRIF: transmembrane protein 16A (TMEM16A, which we also call
            anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride
            channel that is activated by intracellular Ca(2+) and
            Ca(2+)-mobilizing stimuli
REFERENCE   7  (residues 1 to 960)
  AUTHORS   Rock,J.R., Futtner,C.R. and Harfe,B.D.
  TITLE     The transmembrane protein TMEM16A is required for normal
            development of the murine trachea
  JOURNAL   Dev Biol 321 (1), 141-149 (2008)
   PUBMED   18585372
  REMARK    GeneRIF: Study reports that all mice homozygous for a null allele
            of Tmem16a died within one month of birth and exhibited severe
            tracheomalacia with gaps in the tracheal cartilage rings along the
            entire length of the trachea.
REFERENCE   8  (residues 1 to 960)
  AUTHORS   Rock,J.R., Lopez,M.C., Baker,H.V. and Harfe,B.D.
  TITLE     Identification of genes expressed in the mouse limb using a novel
            ZPA microarray approach
  JOURNAL   Gene Expr Patterns 8 (1), 19-26 (2007)
   PUBMED   17911046
REFERENCE   9  (residues 1 to 960)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   10 (residues 1 to 960)
  AUTHORS   Hecht,J., Seitz,V., Urban,M., Wagner,F., Robinson,P.N., Stiege,A.,
            Dieterich,C., Kornak,U., Wilkening,U., Brieske,N., Zwingman,C.,
            Kidess,A., Stricker,S. and Mundlos,S.
  TITLE     Detection of novel skeletogenesis target genes by comprehensive
            analysis of a Runx2(-/-) mouse model
  JOURNAL   Gene Expr Patterns 7 (1-2), 102-112 (2007)
   PUBMED   16829211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122336.4 and AC153792.4.
            
            On Dec 11, 2019 this sequence version replaced NP_848757.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.85 cM"
     Protein         1..960
                     /product="anoctamin-1 isoform 1"
                     /note="transmembrane protein 16A; anoctamin-1"
                     /calculated_mol_wt=110785
     Region          54..317
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          92..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5XXA6; propagated from
                     UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Region          320..900
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     Site            334..354
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            407..427
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            428
                     /site_type="other"
                     /note="Unlikely to bind calcium but may play an important
                     structural role. /evidence=ECO:0000269|PubMed:33378669;
                     propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            494..514
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            543..563
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            582..602
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            632..652
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            700..720
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            721..741
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            759..779
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            806
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Site            867..887
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     Region          928..960
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BHY3.2)"
     CDS             1..960
                     /gene="Ano1"
                     /gene_synonym="Tmem16a"
                     /coded_by="NM_178642.6:250..3132"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40202.2"
                     /db_xref="GeneID:101772"
                     /db_xref="MGI:MGI:2142149"
ORIGIN      
        1 mrvpekystl paedrsvhiv nicaiedlgy lpsegtllns lsvdpdaeck yglyfrdgkr
       61 kvdyilvyhh krasgsrtla rrglqndmvl gtrsvrqdqp lpgkgspvda gspevpmdyh
      121 eddkrfrree yegnlleagl elendedtki hgvgfvkiha pwhvlcreae flklkmptkk
      181 vyhisetrgl lktinsvlqk itdpiqpkva ehrpqttkrl sypfsrekqh lfdltdrdsf
      241 fdsktrstiv yeilkrttct kakysmgits llangvysaa yplhdgdyeg dnvefndrkl
      301 lyeewasygv fykyqpidlv rkyfgekvgl yfawlgaytq mlipasivgv ivflygcatv
      361 denipsmemc dqrynitmcp lcdktcsywk mssacatara shlfdnpatv ffsvfmalwa
      421 atfmehwkrk qmrlnyrwdl tgfeeeeeav kdhpraeyea rvlekslrke srnketdkvk
      481 ltwrdrfpay ftnlvsiifm iavtfaivlg viiyristaa alamnsspsv rsnirvtvta
      541 taviinlvvi illdevygci arwltkievp kteksfeerl tfkafllkfv nsytpifyva
      601 ffkgrfvgrp gdyvyifrsf rmeecapggc lmelciqlsi imlgkqliqn nlfeigipkm
      661 kkfirylklr rqspsdreey vkrkqryevd fnlepfaglt peymemiiqf gfvtlfvasf
      721 plaplfalln niieirldak kfvtelrrpv airakdigiw ynilrgvgkl aviinafvis
      781 ftsdfiprlv ylymysqngt mhgfvnhtls sfnvsdfqng tapndpldlg yevqicrykd
      841 yreppwsehk ydiskdfwav laarlafviv fqnlvmfmsd fvdwvipdip kdisqqihke
      901 kvlmvelfmr eeqgkqqlld twmekekprd vpcnnhsptt hpeagdgspv psyeyhgdal
//
LOCUS       NP_001172012             110 aa            linear   ROD 27-AUG-2025
DEFINITION  insulin-2 preproprotein [Mus musculus].
ACCESSION   NP_001172012
VERSION     NP_001172012.1
DBSOURCE    REFSEQ: accession NM_001185083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Brown,M.E., Miranda,V.E., Nevills,S., Hu,R., Dadi,P.K.,
            Simmons,A.J., Xu,Y., Yang,Y., Yagan,M., Najam,S., Sampson,L.L.,
            Magnuson,M.A., Jacobson,D.A., Lau,K.S., Hodges,E. and Gu,G.
  TITLE     Pancreatic islet beta-cell subtypes are derived from
            biochemically-distinct and nutritionally-regulated islet
            progenitors
  JOURNAL   Nat Commun 16 (1), 5758 (2025)
   PUBMED   40593675
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Traba,S.A., Bacigalupo,L., Fradin,D., Talon,I., Heidenreich,A.C.,
            Muraro,D., Garcia-Bernardo,J., Gribben,C., Lugtu,F., Burgos,J.I.,
            Romero,A., Chhatriwala,M., Pecci,A., Vallier,L. and
            Rodriguez-Segui,S.A.
  TITLE     Endogenous glucocorticoid receptor activation modulates early-stage
            cell differentiation in pancreatic progenitors of mice and humans
  JOURNAL   Development 152 (11) (2025)
   PUBMED   40351285
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Spathies,J., Ratley,G., D'Souza,B.N., Sun,A.A., Gough,P.,
            Chaudhary,P.P., Matriz,J., Yadav,M., Zeldin,J., Freeman,A.F. and
            Myles,I.A.
  TITLE     Skin imaging mass spectrometry of controls versus atopic dermatitis
            patients with and without STAT3 mutations
  JOURNAL   iScience 28 (6), 112644 (2025)
   PUBMED   40510125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Panda,A.C., Kulkarni,S.D., Muralidharan,B., Bakthavachalu,B. and
            Seshadri,V.
  TITLE     Novel splice variant of mouse insulin2 mRNA: implications for
            insulin expression
  JOURNAL   FEBS Lett 584 (6), 1169-1173 (2010)
   PUBMED   20153322
  REMARK    GeneRIF: Alternative splicing of insulin mRNA in mice could result
            in an additional level of regulation in insulin biosynthesis.
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Minn,A.H., Lan,H., Rabaglia,M.E., Harlan,D.M., Peculis,B.A.,
            Attie,A.D. and Shalev,A.
  TITLE     Increased insulin translation from an insulin splice-variant
            overexpressed in diabetes, obesity, and insulin resistance
  JOURNAL   Mol Endocrinol 19 (3), 794-803 (2005)
   PUBMED   15550470
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Zemel,S., Bartolomei,M.S. and Tilghman,S.M.
  TITLE     Physical linkage of two mammalian imprinted genes, H19 and
            insulin-like growth factor 2
  JOURNAL   Nat Genet 2 (1), 61-65 (1992)
   PUBMED   1303252
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Rappolee,D.A., Sturm,K.S., Behrendtsen,O., Schultz,G.A.,
            Pedersen,R.A. and Werb,Z.
  TITLE     Insulin-like growth factor II acts through an endogenous growth
            pathway regulated by imprinting in early mouse embryos
  JOURNAL   Genes Dev 6 (6), 939-952 (1992)
   PUBMED   1317321
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Sawa,T., Ohgaku,S., Morioka,H. and Yano,S.
  TITLE     Molecular cloning and DNA sequence analysis of preproinsulin genes
            in the NON mouse, an animal model of human non-obese,
            non-insulin-dependent diabetes mellitus
  JOURNAL   J Mol Endocrinol 5 (1), 61-67 (1990)
   PUBMED   2397023
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Wentworth,B.M., Schaefer,I.M., Villa-Komaroff,L. and Chirgwin,J.M.
  TITLE     Characterization of the two nonallelic genes encoding mouse
            preproinsulin
  JOURNAL   J Mol Evol 23 (4), 305-312 (1986)
   PUBMED   3104603
REFERENCE   10 (residues 1 to 110)
  AUTHORS   Bunzli,H.F., Glatthaar,B., Kunz,P., Mulhaupt,E. and Humbel,R.E.
  TITLE     Amino acid sequence of the two insulins from mouse (Maus musculus)
  JOURNAL   Hoppe Seylers Z Physiol Chem 353 (3), 451-458 (1972)
   PUBMED   5063718
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP775562.1 and BC099934.1.
            
            Summary: This gene encodes insulin, a peptide hormone that plays a
            vital role in the regulation of carbohydrate and lipid metabolism.
            The encoded precursor protein undergoes proteolytic cleavage to
            produce a disulfide-linked heterodimeric functional protein that is
            stored in secretory granules. An increase in blood glucose levels,
            among others, induces the release of insulin from the secretory
            granules. Mice deficient in the functional hormone encoded by this
            gene develop diabetes mellitus. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP775727.1, BG310959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.0 cM"
     Protein         1..110
                     /product="insulin-2 preproprotein"
                     /note="insulin-2; proinsulin"
                     /calculated_mol_wt=9497
     sig_peptide     1..24
                     /note="/evidence=ECO:0000269|PubMed:5063718; propagated
                     from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=2886
     proprotein      25..110
                     /product="insulin-2 proprotein"
                     /experiment="experimental evidence [PMID:5063718]"
                     /calculated_mol_wt=9497
     mat_peptide     25..54
                     /product="Insulin-2 B chain.
                     /evidence=ECO:0000269|PubMed:3104603. /id=PRO_0000015845"
                     /note="propagated from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=3433
     Region          26..110
                     /region_name="IlGF_insulin_like"
                     /note="IlGF_like family, insulin_like subgroup, specific
                     to vertebrates. Members include a number of peptides
                     including insulin and insulin-like growth factors I and
                     II, which play a variety of roles in controlling processes
                     such as metabolism, growth and...; cd04367"
                     /db_xref="CDD:239833"
     Site            order(32,35,37,108)
                     /site_type="active"
                     /note="putative receptor binding surface [active]"
                     /db_xref="CDD:239833"
     mat_peptide     90..110
                     /product="Insulin-2 A chain.
                     /evidence=ECO:0000269|PubMed:3104603. /id=PRO_0000015847"
                     /note="propagated from UniProtKB/Swiss-Prot (P01326.1)"
                     /calculated_mol_wt=2370
     CDS             1..110
                     /gene="Ins2"
                     /gene_synonym="Ins-2; InsII; Mody; Mody4"
                     /coded_by="NM_001185083.2:80..412"
                     /db_xref="CCDS:CCDS22034.1"
                     /db_xref="GeneID:16334"
                     /db_xref="MGI:MGI:96573"
ORIGIN      
        1 malwmrflpl lallflwesh ptqafvkqhl cgshlvealy lvcgergffy tpmsrreved
       61 pqvaqlelgg gpgagdlqtl alevaqqkrg ivdqcctsic slyqlenycn
//
LOCUS       NP_034266                707 aa            linear   ROD 27-AUG-2025
DEFINITION  eomesodermin homolog isoform 1 [Mus musculus].
ACCESSION   NP_034266 XP_135209
VERSION     NP_034266.2
DBSOURCE    REFSEQ: accession NM_010136.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 707)
  AUTHORS   Medina-Menendez,C., Tirado-Melendro,P., Li,L., Rodriguez-Martin,P.,
            Melgarejo-de la Pena,E., Diaz-Garcia,M., Valdes-Bescos,M.,
            Lopez-Sansegundo,R. and Morales,A.V.
  TITLE     Sox5 controls the establishment of quiescence in neural stem cells
            during postnatal development
  JOURNAL   PLoS Biol 23 (7), e3002654 (2025)
   PUBMED   40720543
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 707)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 707)
  AUTHORS   Bisia,A.M., Xypolita,M.E., Bikoff,E.K., Robertson,E.J. and
            Costello,I.
  TITLE     Eomesodermin in conjunction with the BAF complex promotes expansion
            and invasion of the trophectoderm lineage
  JOURNAL   Nat Commun 16 (1), 5079 (2025)
   PUBMED   40450029
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 707)
  AUTHORS   Saha,S., Debacq,C., Audouard,C., Jungas,T., Dupre,P.,
            Mohamad-Ali,F., Chapat,C., Michaud,H.A., Le Cam,L., Lacroix,M.,
            Ohayon,D. and Davy,A.
  TITLE     Acute dietary methionine restriction triggers cell cycle arrest and
            reversible growth defects in the neocortex
  JOURNAL   iScience 28 (6), 112705 (2025)
   PUBMED   40524957
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 707)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 707)
  AUTHORS   Kimura,N., Nakashima,K., Ueno,M., Kiyama,H. and Taga,T.
  TITLE     A novel mammalian T-box-containing gene, Tbr2, expressed in mouse
            developing brain
  JOURNAL   Brain Res Dev Brain Res 115 (2), 183-193 (1999)
   PUBMED   10407135
REFERENCE   7  (residues 1 to 707)
  AUTHORS   Hancock,S.N., Agulnik,S.I., Silver,L.M. and Papaioannou,V.E.
  TITLE     Mapping and expression analysis of the mouse ortholog of Xenopus
            Eomesodermin
  JOURNAL   Mech Dev 81 (1-2), 205-208 (1999)
   PUBMED   10330501
REFERENCE   8  (residues 1 to 707)
  AUTHORS   Ciruna,B.G. and Rossant,J.
  TITLE     Expression of the T-box gene Eomesodermin during early mouse
            development
  JOURNAL   Mech Dev 81 (1-2), 199-203 (1999)
   PUBMED   10330500
REFERENCE   9  (residues 1 to 707)
  AUTHORS   Wattler,S., Russ,A., Evans,M. and Nehls,M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   10 (residues 1 to 707)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC173340.1.
            
            On Dec 23, 2005 this sequence version replaced NP_034266.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094319.1, AK089817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 70.21 cM"
     Protein         1..707
                     /product="eomesodermin homolog isoform 1"
                     /note="T-brain-2; T-box brain protein 2; eomesodermin
                     homolog"
                     /calculated_mol_wt=74670
     Region          27..125
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54839.3)"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54839.3)"
     Region          268..458
                     /region_name="T-box_TBR2"
                     /note="DNA-binding domain of T-box brain protein 2 and
                     related T-box proteins; cd20205"
                     /db_xref="CDD:410331"
     Site            order(296..297,330,332,375,378,394..395,435,437,443,446,
                     450..452,455..456)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410331"
     Site            order(314,316,349..351,357..358,388,407,421)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410331"
     Site            473
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54839.3)"
     Region          484..705
                     /region_name="T-box_assoc"
                     /note="T-box transcription factor-associated; pfam16176"
                     /db_xref="CDD:465042"
     Region          592..707
                     /region_name="Required for transcription activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O54839.3)"
     Region          642..689
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54839.3)"
     CDS             1..707
                     /gene="Eomes"
                     /gene_synonym="TBR-2; Tbr2"
                     /coded_by="NM_010136.4:470..2593"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23603.1"
                     /db_xref="GeneID:13813"
                     /db_xref="MGI:MGI:1201683"
ORIGIN      
        1 mqlgeqllvs svnlpgahfy slesargggg gggggggggg gsvsllpgaa pspqrldldk
       61 askkfpgslp cqagsaepag agagapaaml sdadagdtfg stsavakpgp pdgrkgspca
      121 eeelpsaata aatarysmds lsseryylps pgpqgselaa pcslfqypaa agaahgpvyp
      181 asngarypyg smlppggfpa avcpparaqf gpaagsgsga gssgggaggp gaypygqgsp
      241 lygpyagtsa agscgglggl gvpgsgfrah vylcnrplwl kfhrhqtemi itkqgrrmfp
      301 flsfningln ptahynvfve vvladpnhwr fqggkwvtcg kadnnmqgnk myvhpespnt
      361 gshwmrqeis fgklkltnnk gannnntqmi vlqslhkyqp rlhivevted gvedlnepsk
      421 tqtftfsetq fiavtayqnt ditqlkidhn pfakgfrdny dsmytasend rltpsptdsp
      481 rshqivpggr ygvqnffpep fvntlpqary yngertvpqt ngllspqqse evanppqrwl
      541 vtpvqqpvtn kldigsyese ytsstllpyg ikslplqtsh algyypdptf pamagwggrg
      601 ayqrkmaagl pwtsrmsppv fpedqlakek vkeeissswi etppsiksld ssdsgvynsa
      661 ckrkrlspst psngnsppik cedinteeys kdtskgmgay yafytsp
//
LOCUS       NP_001192243             749 aa            linear   ROD 27-AUG-2025
DEFINITION  signal transducer and activator of transcription 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001192243
VERSION     NP_001192243.1
DBSOURCE    REFSEQ: accession NM_001205314.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Nelson,A.N., Sinha,S., Mullin,S.J., Carver,S.S., Cafiero,T.R.,
            Lin,A.E., Schwartz,R.E. and Ploss,A.
  TITLE     STAT1-mediated interferon signaling in the hematopoietic system is
            essential for restricting Usutu virus infection in vivo
  JOURNAL   PLoS Negl Trop Dis 19 (7), e0013317 (2025)
   PUBMED   40694555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Risley,C.A., Schultz,M.D., Allie,S.R., Liu,S., Peel,J.N.,
            Nellore,A., Fucile,C.F., Scharer,C.D., Boss,J.M., Randall,T.D.,
            Rosenberg,A.F. and Lund,F.E.
  TITLE     Transcription factor T-bet regulates the maintenance and
            differentiation potential of lymph node and lung effector memory B
            cell subsets
  JOURNAL   Immunity 58 (7), 1706-1724 (2025)
   PUBMED   40543512
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Philips,R.L., Liao,Y.C., Lau,C.M., Morrison,T.A., Jiang,K.,
            Hutchinson,A., Shayne,J., Yao,C., Sun,J.C., Hickman,H.D.,
            Milner,J.D., Holland,S., Kanno,Y., Lionakis,M.S. and O'Shea,J.J.
  TITLE     An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte
            programs during viral infection
  JOURNAL   Sci Immunol 10 (107), eado5986 (2025)
   PUBMED   40446018
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Novak,U., Harpur,A.G., Paradiso,L., Kanagasundaram,V.,
            Jaworowski,A., Wilks,A.F. and Hamilton,J.A.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Finidori,J. and Kelly,P.A.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Harroch,S., Gothelf,Y., Revel,M. and Chebath,J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Matsuda,T. and Hirano,T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Zhong,Z., Wen,Z. and Darnell,J.E. Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039458.1, AK084855.1, BC042551.1 and BX513160.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform 2),
            compared to isoform 1. Variants 2, 3, and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084855.1, SRR1660813.156759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..749
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /calculated_mol_wt=87184
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            114
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            175
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            296
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          317..477
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,459..460,463)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Site            366
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            525
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          557..707
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(584,602,630,632)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(631,647)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            637
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(641..642,706)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            665
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK1, JAK2 or TYK2.
                     /evidence=ECO:0000269|PubMed:19088846,
                     ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:38621137;
                     propagated from UniProtKB/Swiss-Prot (P42225.1)"
     Site            708
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000269|PubMed:17332413,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          715..739
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     Site            724
                     /site_type="other"
                     /note="Required for recruitment of EP300/p300.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2 and MAPK14.
                     /evidence=ECO:0000269|PubMed:11972023,
                     ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:38621137;
                     propagated from UniProtKB/Swiss-Prot (P42225.1)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000305|PubMed:17332413; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            748
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by IKKB.
                     /evidence=ECO:0000269|PubMed:38621137; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     CDS             1..749
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_001205314.1:336..2585"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlet tslpvvvisn vsqlpsgwas ilwynmlvte
      481 prnlsfflnp pcawwsqlse vlswqfssvt krglnadqls mlgekllgpn agpdglipwt
      541 rfckenindk nfsfwpwidt ilelikkhll clwndgcimg fiskereral lkdqqpgtfl
      601 lrfsessreg aitftwvers qnggepdfha vepytkkels avtfpdiirn ykvmaaenip
      661 enplkylypn idkdhafgky ysrpkeapep melddpkrtg yiktelisvs evhpsrlqtt
      721 dnllpmspee fdemsrivgp efdsmmstv
//
LOCUS       NP_034793                433 aa            linear   ROD 27-AUG-2025
DEFINITION  keratin, type I cytoskeletal 17 [Mus musculus].
ACCESSION   NP_034793
VERSION     NP_034793.1
DBSOURCE    REFSEQ: accession NM_010663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Xu,Y., Cohen,E., Johnson,C.N., Parent,C.A. and Coulombe,P.A.
  TITLE     Repeated stress to the skin amplifies neutrophil infiltration in a
            keratin 17- and PKCalpha-dependent manner
  JOURNAL   PLoS Biol 22 (8), e3002779 (2024)
   PUBMED   39159283
  REMARK    GeneRIF: Repeated stress to the skin amplifies neutrophil
            infiltration in a keratin 17- and PKCalpha-dependent manner.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Chiang,C., Swan,R.Z., Grachtchouk,M., Bolinger,M., Litingtung,Y.,
            Robertson,E.K., Cooper,M.K., Gaffield,W., Westphal,H., Beachy,P.A.
            and Dlugosz,A.A.
  TITLE     Essential role for Sonic hedgehog during hair follicle
            morphogenesis
  JOURNAL   Dev Biol 205 (1), 1-9 (1999)
   PUBMED   9882493
REFERENCE   8  (residues 1 to 433)
  AUTHORS   McGowan,K.M. and Coulombe,P.A.
  TITLE     Onset of keratin 17 expression coincides with the definition of
            major epithelial lineages during skin development
  JOURNAL   J Cell Biol 143 (2), 469-486 (1998)
   PUBMED   9786956
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Three cDNA sequences of mouse type I keratins. Cellular
            localization of the mRNAs in normal and hyperproliferative tissues
  JOURNAL   J Biol Chem 262 (2), 938-945 (1987)
   PUBMED   2433272
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Steinert,P.M., Rice,R.H., Roop,D.R., Trus,B.L. and Steven,A.C.
  TITLE     Complete amino acid sequence of a mouse epidermal keratin subunit
            and implications for the structure of intermediate filaments
  JOURNAL   Nature 302 (5911), 794-800 (1983)
   PUBMED   6188955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17, BC132454.1,
            EH104192.1 and EH105154.1.
            
            Summary: The protein encoded by this gene is a member of the type I
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. The
            encoded protein is a cytokeratin required for the normal growth of
            hair follicles and may act in psoriasis as an immunopathogenic
            autoantigen. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032161.2, AB013608.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.44 cM"
     Protein         1..433
                     /product="keratin, type I cytoskeletal 17"
                     /note="CK-17; cytokeratin-17; keratin complex 1, acidic,
                     gene 17"
                     /calculated_mol_wt=48031
     Region          1..83
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04695; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            13
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04695; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q61414; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            32
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFU8; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KA1.
                     /evidence=ECO:0000250|UniProtKB:Q04695; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          84..394
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          84..120
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q04695; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          121..138
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          139..230
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          231..250
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          251..392
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            279
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFV3; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Site            323
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04695; propagated from
                     UniProtKB/Swiss-Prot (Q9QWL7.3)"
     Region          393..433
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWL7.3)"
     CDS             1..433
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /coded_by="NM_010663.3:65..1366"
                     /db_xref="CCDS:CCDS25415.1"
                     /db_xref="GeneID:16667"
                     /db_xref="MGI:MGI:96691"
ORIGIN      
        1 mtttirqfts sssikgssgl gggssrtscr lsgslgagsc rlgsasglgs algsnsyssc
       61 ysfgtgsgyg gnfggvdgll aggekatmqn lndrlasyld kvraleeant elevkirdwy
      121 qkqapgpard ysayyhtied lknkilvatv dnasillqid narlaaddfr tkfeteqalr
      181 msveadingl rrvldeltla radlemqien lkeelaylkk nheeemnalr gqvggeinve
      241 mdaapgvdls rilsemrdqy ekmaeknrkd aedwffskte elnrevatns elvqsgksei
      301 selrrtmqal eielqsqlsm kaslegslae tenrycvqls qiqgligsve eqlaqlrcem
      361 eqqnqeykil ldvktrleqe iatyrrlleg edahltqykp kepvttrqvr tiveevqdgk
      421 vissreqvhq ttr
//
LOCUS       NP_001300847             152 aa            linear   ROD 27-AUG-2025
DEFINITION  eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2
            precursor [Mus musculus].
ACCESSION   NP_001300847
VERSION     NP_001300847.1
DBSOURCE    REFSEQ: accession NM_001313918.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 152)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 152)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 152)
  AUTHORS   Shin,Y.C., Latorre-Muro,P., Djurabekova,A., Zdorevskyi,O.,
            Bennett,C.F., Burger,N., Song,K., Xu,C., Paulo,J.A., Gygi,S.P.,
            Sharma,V., Liao,M. and Puigserver,P.
  TITLE     Structural basis of respiratory complex adaptation to cold
            temperatures
  JOURNAL   Cell 187 (23), 6584-6598 (2024)
   PUBMED   39395414
REFERENCE   4  (residues 1 to 152)
  AUTHORS   Song,C., Chen,Q., Xu,J., He,K., Guo,Q., Teng,X., Xue,H., Xiao,L.,
            Tian,D., Jin,S., An,C. and Wu,Y.
  TITLE     H2S alleviated sepsis-induced acute kidney injury by inhibiting
            PERK/Bax-Bcl2 pathway
  JOURNAL   Nitric Oxide 152, 11-18 (2024)
   PUBMED   39271041
  REMARK    GeneRIF: H2S alleviated sepsis-induced acute kidney injury by
            inhibiting PERK/Bax-Bcl2 pathway.
REFERENCE   5  (residues 1 to 152)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 152)
  AUTHORS   Brewer,J.W. and Diehl,J.A.
  TITLE     PERK mediates cell-cycle exit during the mammalian unfolded protein
            response
  JOURNAL   Proc Natl Acad Sci U S A 97 (23), 12625-12630 (2000)
   PUBMED   11035797
REFERENCE   7  (residues 1 to 152)
  AUTHORS   Delepine,M., Nicolino,M., Barrett,T., Golamaully,M., Lathrop,G.M.
            and Julier,C.
  TITLE     EIF2AK3, encoding translation initiation factor 2-alpha kinase 3,
            is mutated in patients with Wolcott-Rallison syndrome
  JOURNAL   Nat Genet 25 (4), 406-409 (2000)
   PUBMED   10932183
REFERENCE   8  (residues 1 to 152)
  AUTHORS   Bertolotti,A., Zhang,Y., Hendershot,L.M., Harding,H.P. and Ron,D.
  TITLE     Dynamic interaction of BiP and ER stress transducers in the
            unfolded-protein response
  JOURNAL   Nat Cell Biol 2 (6), 326-332 (2000)
   PUBMED   10854322
REFERENCE   9  (residues 1 to 152)
  AUTHORS   Harding,H.P., Zhang,Y., Bertolotti,A., Zeng,H. and Ron,D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   10 (residues 1 to 152)
  AUTHORS   Harding,H.P., Zhang,Y. and Ron,D.
  TITLE     Protein translation and folding are coupled by an
            endoplasmic-reticulum-resident kinase
  JOURNAL   Nature 397 (6716), 271-274 (1999)
   PUBMED   9930704
  REMARK    Erratum:[Nature 1999 Mar 4;398(6722):90]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC156398.13 and AK010397.1.
            
            Summary: The protein encoded by this gene phosphorylates the alpha
            subunit of eukaryotic translation-initiation factor 2, leading to
            its inactivation, and thus to a rapid reduction of translational
            initiation and repression of global protein synthesis. This protein
            is thought to modulate mitochondrial function. It is a type I
            membrane protein located in the endoplasmic reticulum (ER), where
            it is induced by ER stress caused by malfolded proteins. Mutations
            in a similar gene in human are associated with Wolcott-Rallison
            syndrome. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks multiple alternate 3'
            exons and uses an alternate 3' terminal exon, compared to variant
            1. The encoded isoform (2) has a distinct and shorter C-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010397.1, BG143484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.09 cM"
     Protein         1..152
                     /product="eukaryotic translation initiation factor 2-alpha
                     kinase 3 isoform 2 precursor"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="pancreatic eIF2-alpha kinase; PRKR-like endoplasmic
                     reticulum kinase; protein tyrosine kinase EIF2AK3"
                     /calculated_mol_wt=13153
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2351
     Region          72..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2B5.1)"
     Region          100..>127
                     /region_name="Luminal_IRE1_like"
                     /note="The Luminal domain, a dimerization domain, of
                     Inositol-requiring protein 1-like proteins; cl14874"
                     /db_xref="CDD:276097"
     CDS             1..152
                     /gene="Eif2ak3"
                     /gene_synonym="Pek; Perk"
                     /coded_by="NM_001313918.1:212..670"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS85063.1"
                     /db_xref="GeneID:13666"
                     /db_xref="MGI:MGI:1341830"
ORIGIN      
        1 meratrpgpr alllllflll gcaagisava parsllapas etvfglgaaa aptsaarvpa
       61 vataevtved aealpaaage pesratepdd dvelrprgrs lviistldgr iaaldaendg
      121 kkqwdldvgs gslvssslsk pegthktssk ec
//
LOCUS       NP_001300942             171 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 2 [Mus musculus].
ACCESSION   NP_001300942
VERSION     NP_001300942.1
DBSOURCE    REFSEQ: accession NM_001314013.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 171)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 171)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 171)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 171)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 171)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 171)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 171)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 171)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 171)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 171)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks an alternate internal
            exon and initiates translation at a downstream start codon compared
            to variant 1. The resulting isoform (2) has a shorter and distinct
            N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.4698357.1,
                                           SRR17253014.2543474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..171
                     /product="autophagy protein 5 isoform 2"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=19847
     Region          2..166
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..171
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001314013.2:477..992"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 msfpekdllh cpskdaveah fmscmkeada lkhksqvine mqkkdhkqlw mglqndrfdq
       61 fwainrklme yppeengfry ipfriyqttt erpfiqklfr pvaadgqlht lgdllrevcp
      121 savapedgek rsqvmihgie pmletplqwl sehlsypdnf lhisivpqpt d
//
LOCUS       NP_001419107             475 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor EB [Mus musculus].
ACCESSION   NP_001419107 XP_006524070
VERSION     NP_001419107.1
DBSOURCE    REFSEQ: accession NM_001432178.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Custode,B.M., Annunziata,F., Dos Santos Matos,F., Schiano,V.,
            Maffia,V., Lillo,M., Colonna,R., De Cegli,R., Ballabio,A. and
            Pastore,N.
  TITLE     Folliculin depletion results in liver cell damage and
            cholangiocarcinoma through MiT/TFE activation
  JOURNAL   Cell Death Differ 32 (8), 1460-1472 (2025)
   PUBMED   40189703
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Kumar,G.V.N., Wang,R.S., Sharma,A.X., David,N.L., Amorim,T.,
            Sinden,D.S., Doshi,N.K., Wabitsch,M., Gingras,S., Ejaz,A.,
            Rubin,J.P., Maron,B.A., Fazeli,P.K. and Steinhauser,M.L.
  TITLE     Non-canonical lysosomal lipolysis drives mobilization of adipose
            tissue energy stores with fasting
  JOURNAL   Nat Commun 16 (1), 1330 (2025)
   PUBMED   39900947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Lei,Q., Chen,X., Xiong,Y., Li,S., Wang,J., He,H. and Deng,Y.
  TITLE     Lysosomal Ca2+ release-facilitated TFEB nuclear translocation
            alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons
  JOURNAL   Sci Rep 14 (1), 24836 (2024)
   PUBMED   39438678
  REMARK    GeneRIF: Lysosomal Ca[2+] release-facilitated TFEB nuclear
            translocation alleviates ischemic brain injury by attenuating
            autophagic/lysosomal dysfunction in neurons.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124830.8 and AC113536.10.
            
            On Jul 27, 2024 this sequence version replaced XP_006524070.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR4048177.31423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..475
                     /product="transcription factor EB"
                     /calculated_mol_wt=52483
     Region          1..166
                     /region_name="Interaction with ACSS2.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          4..161
                     /region_name="MITF_TFEB_C_3_N"
                     /note="MITF/TFEB/TFEC/TFE3 N-terminus; pfam15951"
                     /db_xref="CDD:464952"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            121
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          135..152
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          155..164
                     /region_name="Strong transcription activation domain.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MTOR.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          225..315
                     /region_name="bHLHzip_TFEB"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in transcription factor EB (TFEB) and similar
                     proteins; cd18927"
                     /db_xref="CDD:381497"
     Site            order(239..240,242..243,246..247,251,272..273)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381497"
     Region          244..247
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P19484"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            order(249..250,253..254,256,260,273,277..278,281,283..285,
                     287..288,290..291,294,297..299)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381497"
     Region          297..318
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          320..472
                     /region_name="DUF3371"
                     /note="Domain of unknown function (DUF3371); pfam11851"
                     /db_xref="CDD:463372"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          351..429
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19484; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Region          445..475
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R210.2)"
     CDS             1..475
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /coded_by="NM_001432178.1:224..1651"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
ORIGIN      
        1 masriglrmq lmreqaqqee qrermqqqav mhymqqqqqq qqqlggpptp aintpvhfqs
       61 pppvpgevlk vqsylenpts yhlqqsqhqk vreylsetyg nkfaahvspa qgspkpapaa
      121 spgvraghvl stsagnsapn spmamlhiss npekefddvi dnimrldsvl gyinpemqmp
      181 ntlplssshl nvysgdpqvt asmvgvtsss cpadltqkre ltdaesrala kerqkkdnhn
      241 lierrrrfni ndrikelgml ipkandldvr wnkgtilkas vdyirrmqkd lqksrelenh
      301 srrlemtnkq lwlriqelem qarvhglptt spsgvnmael aqqvvkqelp sedgpgealm
      361 lgpevpepeq mpalppqapl psaaqpqspf hhldfshgls fggggdegpt gypdtlgteh
      421 gspfpnlskk dldlmlldds llplasdplf stmspeaska ssrrssfsme egdvl
//
LOCUS       NP_001348431             146 aa            linear   ROD 27-AUG-2025
DEFINITION  allograft inflammatory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001348431
VERSION     NP_001348431.1
DBSOURCE    REFSEQ: accession NM_001361502.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Demenego,G., Mancinelli,S., Borreca,A., Proce,R.O., Aragona,V.,
            Miotto,M., Cremonesi,M., Zucchelli,L., Corradini,I., Kim,E.,
            Ilic,K., Fraviga,E., Pellegrino,L., Badolato,R., Rusconi,R.,
            Pozzi,D., Kallikourdis,M., Cash,D., Matteoli,M. and Lodato,S.
  TITLE     Neurodevelopmental origins of structural and psychomotor defects in
            CXCR4-linked primary immunodeficiency
  JOURNAL   Neuron 113 (16), 2636-2655 (2025)
   PUBMED   40482638
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Hohsfield,L.A., Kim,S.J., Barahona,R.A., Henningfield,C.M.,
            Mansour,K., Vallejo,K.D., Tsourmas,K.I., Kwang,N.E., Ghorbanian,Y.,
            Angulo,J.A.A., Gao,P., Pachow,C., Inlay,M.A., Walsh,C.M., Xu,X.,
            Lane,T.E. and Green,K.N.
  TITLE     Identification of the velum interpositum as a meningeal-CNS route
            for myeloid cell trafficking into the brain
  JOURNAL   Neuron 113 (15), 2455-2473 (2025)
   PUBMED   40466634
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Guo,M., Liu,L., Mao,X., Xiao,M., He,X., Pan,X., Chen,Y., Yi,W.,
            Li,Q., Piao,X., Wang,H., Du,Y. and Cheng,Y.
  TITLE     Deciphering the role of CAPZA2 in neurodevelopmental disorders:
            insights from mouse models
  JOURNAL   Commun Biol 8 (1), 1048 (2025)
   PUBMED   40659881
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Sasaki,Y., Ohsawa,K., Kanazawa,H., Kohsaka,S. and Imai,Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Ohsawa,K., Imai,Y., Kanazawa,H., Sasaki,Y. and Kohsaka,S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Lund,T., Shaikh,S., Kendall,E., Campbell,R.D., Hattori,M.,
            Makino,S. and Cooke,A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Transcript Variant: This variant (3) lacks an alternate exon
            compared to variant 1. The resulting isoform (b) has a shorter and
            distinct N-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU962218.1, CN834368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..146
                     /product="allograft inflammatory factor 1 isoform b"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16747
     Region          <47..112
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..146
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001361502.2:143..583"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 mkpeeisrgk afgllkaqqe erleginkqf lddpkysnde dlpskleafk vkymefdlng
       61 ngdidimslk rmleklgvpk thlelkrlir evssgseetf sysdflrmml gkrsailrmi
      121 lmyeeknkeh krptgppakk aiselp
//
LOCUS       NP_034261                290 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein EMX1 [Mus musculus].
ACCESSION   NP_034261 XP_132640
VERSION     NP_034261.2
DBSOURCE    REFSEQ: accession NM_010131.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Yigit,B.N., Tufekci,D., Viola,V., Kirim,B.A., Zaidi,D., Francis,F.
            and Ozlu,N.
  TITLE     Loss of Eml1 alters microtubule-associated protein networks in
            mouse brain heterotopia
  JOURNAL   Commun Biol 8 (1), 989 (2025)
   PUBMED   40610677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 290)
  AUTHORS   Wu,M., Wu,X., Sun,H., Wang,W., Zhang,L., Liu,X., Zhang,Y.,
            Zhang,X., Liu,J., Shen,B. and Zhou,T.
  TITLE     VIRMA-mediated m6A modification regulates forebrain formation
            through modulating ribosome biogenesis
  JOURNAL   Sci Adv 11 (26), eadq9643 (2025)
   PUBMED   40577453
REFERENCE   5  (residues 1 to 290)
  AUTHORS   Chen,L., Li,Y., Yu,Y., Cai,M., Li,H., Huang,M., Yang,G., Guo,J.,
            Wang,H., Song,Z., Shen,W., Jiang,H. and Wu,H.
  TITLE     EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase-3
            and Aifm1 Splicing Pathways
  JOURNAL   Adv Sci (Weinh), e04200 (2025) In press
   PUBMED   40448601
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 290)
  AUTHORS   Qiu,M., Bulfone,A., Martinez,S., Meneses,J.J., Shimamura,K.,
            Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Null mutation of Dlx-2 results in abnormal morphogenesis of
            proximal first and second branchial arch derivatives and abnormal
            differentiation in the forebrain
  JOURNAL   Genes Dev 9 (20), 2523-2538 (1995)
   PUBMED   7590232
REFERENCE   7  (residues 1 to 290)
  AUTHORS   Simeone,A., Acampora,D., Gulisano,M., Stornaiuolo,A. and
            Boncinelli,E.
  TITLE     Nested expression domains of four homeobox genes in developing
            rostral brain
  JOURNAL   Nature 358 (6388), 687-690 (1992)
   PUBMED   1353865
REFERENCE   8  (residues 1 to 290)
  AUTHORS   Holland,P., Ingham,P. and Krauss,S.
  TITLE     Development and evolution. Mice and flies head to head
  JOURNAL   Nature 358 (6388), 627-628 (1992)
   PUBMED   1353864
REFERENCE   9  (residues 1 to 290)
  AUTHORS   Simeone,A., Gulisano,M., Acampora,D., Stornaiuolo,A., Rambaldi,M.
            and Boncinelli,E.
  TITLE     Two vertebrate homeobox genes related to the Drosophila empty
            spiracles gene are expressed in the embryonic cerebral cortex
  JOURNAL   EMBO J 11 (7), 2541-2550 (1992)
   PUBMED   1352754
REFERENCE   10 (residues 1 to 290)
  AUTHORS   Iwasaki,Y., Ohkubo,A., Kamei,S. and Kosaka,K.
  TITLE     [Serial determination of serum GOT isozyme activities for the
            evaluation of acute hepatic damage (author's transl)]
  JOURNAL   Nihon Shokakibyo Gakkai Zasshi 75 (1), 34-43 (1978)
   PUBMED   642215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153605.2.
            
            On Feb 9, 2024 this sequence version replaced NP_034261.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.4479957.1,
                                           SRR10662773.572643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.21 cM"
     Protein         1..290
                     /product="homeobox protein EMX1"
                     /note="empty spiracles-like protein 1; empty spiracles
                     homolog 1"
                     /calculated_mol_wt=31427
     Region          193..249
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..290
                     /gene="Emx1"
                     /coded_by="NM_010131.3:287..1159"
                     /db_xref="CCDS:CCDS20290.1"
                     /db_xref="GeneID:13796"
                     /db_xref="MGI:MGI:95387"
ORIGIN      
        1 mcqawctprt aaapghrafp raplphsasa aatmfqpaak rgftieslva kdggtggspg
       61 sggagshpla vaaseeplrp talnyphpsa aetafvsgfp aaaaagagrs lyggpelvfp
      121 eamnhpaltv hpahqlgsss lqpphsffsa qhrdplhfyp wvlrnrffgh rfqasdvpqd
      181 glllhgpfar kpkrirtafs psqllrlera feknhyvvga erkqlagsls lsetqvkvwf
      241 qnrrtkykrq kleeegpese qkkkgshhin rwriatkqan gedidvtsnd
//
LOCUS       NP_001076021             462 aa            linear   ROD 27-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRIM21 [Mus musculus].
ACCESSION   NP_001076021
VERSION     NP_001076021.1
DBSOURCE    REFSEQ: accession NM_001082552.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Kim,D.S., Park,Y., Tsokos,G.C., Cho,M.L. and Kwok,S.K.
  TITLE     The ubiquitin E3 ligase TRIM21 suppresses type I interferon
            signaling via STING degradation and ameliorates systemic
            autoimmunity
  JOURNAL   Exp Mol Med 57 (7), 1555-1566 (2025)
   PUBMED   40610751
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Mehlmann,L.M., Uliasz,T.F., Yee,S.P., Kaback,D. and Lowther,K.M.
  TITLE     Generation and Characterization of a TRIM21 Overexpressing Mouse
            Line
  JOURNAL   Genesis 62 (5), e23616 (2024)
   PUBMED   39487578
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Yang,L., Hu,C., Chen,X., Zhang,J., Feng,Z., Xiao,Y., He,W., Cui,T.,
            Zhang,X., Yang,Y., Zhang,Y. and Yan,Y.
  TITLE     Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2
            nuclear translocation and astrocyte activation in experimental
            autoimmune encephalomyelitis
  JOURNAL   Elife 13, 98181 (2024)
   PUBMED   39264698
  REMARK    GeneRIF: Upregulated expression of ubiquitin ligase TRIM21 promotes
            PKM2 nuclear translocation and astrocyte activation in experimental
            autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 462)
  AUTHORS   Guo,Y.Y., Gao,Y., Zhao,Y.L., Xie,C., Gan,H., Cheng,X., Yang,L.P.,
            Hu,J., Shu,H.B., Zhong,B., Lin,D. and Yao,J.
  TITLE     Viral infection and spread are inhibited by the polyubiquitination
            and downregulation of TRPV2 channel by the interferon-stimulated
            gene TRIM21
  JOURNAL   Cell Rep 43 (4), 114095 (2024)
   PUBMED   38613787
  REMARK    GeneRIF: Viral infection and spread are inhibited by the
            polyubiquitination and downregulation of TRPV2 channel by the
            interferon-stimulated gene TRIM21.
REFERENCE   5  (residues 1 to 462)
  AUTHORS   Lin,M., Xian,H., Chen,Z., Wang,S., Liu,M., Liang,W., Tang,Q.,
            Liu,Y., Huang,W., Che,D., Guo,C., Idiiatullina,E., Fang,R.,
            Al-Azab,M., Chang,J., Wang,R., Li,X., Zuo,X., Zhang,Y., Zhao,J.,
            Tang,Y., Jin,S., He,Z., Feng,D., Lu,L., Zhang,K., Wu,Y., Bai,F.,
            Lew,A.M., Cui,J., Wu,Y., Gu,X. and Zhang,Y.
  TITLE     MCM8-mediated mitophagy protects vascular health in response to
            nitric oxide signaling in a mouse model of Kawasaki disease
  JOURNAL   Nat Cardiovasc Res 2 (8), 778-792 (2023)
   PUBMED   39195969
REFERENCE   6  (residues 1 to 462)
  AUTHORS   Keeble,A.H., Khan,Z., Forster,A. and James,L.C.
  TITLE     TRIM21 is an IgG receptor that is structurally, thermodynamically,
            and kinetically conserved
  JOURNAL   Proc Natl Acad Sci U S A 105 (16), 6045-6050 (2008)
   PUBMED   18420815
  REMARK    GeneRIF: TRIM21 is a previously undescribed type of IgG receptor
            based on a non-Ig scaffold whose interaction at the fundamental
            level-structural, thermodynamic, and kinetic-is evolutionarily
            conserved.
REFERENCE   7  (residues 1 to 462)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (residues 1 to 462)
  AUTHORS   Kong,H.J., Anderson,D.E., Lee,C.H., Jang,M.K., Tamura,T.,
            Tailor,P., Cho,H.K., Cheong,J., Xiong,H., Morse,H.C. 3rd and
            Ozato,K.
  TITLE     Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase
            that ubiquitinates IRF-8 and enhances cytokine expression in
            macrophages
  JOURNAL   J Immunol 179 (1), 26-30 (2007)
   PUBMED   17579016
  REMARK    GeneRIF: Ro52 is an E3 ligase for interferon regulatory factor
            (IRF)-8 that acts in a non-degradation pathway of ubiquitination
            and contributes to the elicitation of innate immunity in
            macrophages.
REFERENCE   9  (residues 1 to 462)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   10 (residues 1 to 462)
  AUTHORS   Keech,C.L., Gordon,T.P. and McCluskey,J.
  TITLE     Structural differences between the human and mouse 52-kD Ro
            autoantigens associated with poorly conserved autoantibody activity
            across species
  JOURNAL   Clin Exp Immunol 104 (2), 255-263 (1996)
   PUBMED   8625517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ051157.1, AK152619.1, AK150484.1 and BB681113.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 5'
            non-coding region, hence, has a shorter 5' UTR compared to variant
            1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152619.1, AK150484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.76 cM"
     Protein         1..462
                     /product="E3 ubiquitin-protein ligase TRIM21"
                     /EC_number="2.3.2.27"
                     /note="Sjogren syndrome antigen A1; tripartite motif
                     protein 21; 52 kDa Ro protein; 52kD Ro/SSA autoantigen;
                     SS-A; ro(SS-A); sjoegren syndrome type A antigen;
                     tripartite motif-containing protein 21; 52 kDa
                     ribonucleoprotein autoantigen Ro/SS-A; RING-type E3
                     ubiquitin transferase TRIM21"
                     /calculated_mol_wt=53197
     Region          1..77
                     /region_name="RING-HC_TRIM21_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing protein TRIM21 and similar proteins;
                     cd16596"
                     /db_xref="CDD:438258"
     Region          85..128
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:469587"
     Region          <146..>274
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          283..460
                     /region_name="SPRY_PRY_TRIM21"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     21 (TRIM21) also known as 52kD Ribonucleoprotein
                     Autoantigen (Ro52); cd12900"
                     /db_xref="CDD:293957"
     CDS             1..462
                     /gene="Trim21"
                     /gene_synonym="Ro52; Ssa1"
                     /coded_by="NM_001082552.2:131..1519"
                     /db_xref="CCDS:CCDS40051.1"
                     /db_xref="GeneID:20821"
                     /db_xref="MGI:MGI:106657"
ORIGIN      
        1 mslekmweev tcsicldpmv epmsiecghc fckecifevg knggsscpec rqqfllrnlr
       61 pnrhianmve nlkqiaqntk kstqethcmk hgeklhlfce edgqalcwvc aqsgkhrdht
      121 rvpieeaakv yqekihvale klrkgkelae kmemdltmqr tdwkrnidtq ksrihaefal
      181 qnsllaqeeq rqlqrlekdq reylrllgkk eaelaeknqa lqeliseler rirgselell
      241 qevriilers gswnldtldi dapdltstcp vpgrkkmlrt cwvhitldrn tanswliisk
      301 drrqvrmgdt hqnvsdneer fsnypmvlga qrfssgkmyw evdvtqkeaw dlgvcrdsvq
      361 rkgqfslspe ngfwtiwlwq dsyeagtspq ttlhiqvppc qigifvdyea gvvsfynitd
      421 hgsliytfse cvfagplrpf fnvgfnysgg naaplklcpl km
//
LOCUS       NP_001409025             466 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1A adrenergic receptor isoform 1 [Mus musculus].
ACCESSION   NP_001409025 XP_017171289
VERSION     NP_001409025.1
DBSOURCE    REFSEQ: accession NM_001422096.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Gural,B., Kirkland,L., Hockett,A., Sandroni,P., Zhang,J.,
            Rosa-Garrido,M., Swift,S.K., Chapski,D.J., Flinn,M.A.,
            O'Meara,C.C., Vondriska,T.M., Patterson,M., Jensen,B.C. and
            Rau,C.D.
  TITLE     Novel insights into post-myocardial infarction cardiac remodeling
            through algorithmic detection of cell-type composition shifts
  JOURNAL   PLoS Genet 21 (7), e1011807 (2025)
   PUBMED   40705823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Docherty,J.R.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Lin,F., Owens,W.A., Chen,S., Stevens,M.E., Kesteven,S.,
            Arthur,J.F., Woodcock,E.A., Feneley,M.P. and Graham,R.M.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (residues 1 to 466)
  AUTHORS   O'Connell,T.D., Rokosh,D.G. and Simpson,P.C.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Xiao,L., Scofield,M.A. and Jeffries,W.B.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (residues 1 to 466)
  AUTHORS   Rockman,H.A., Koch,W.J. and Lefkowitz,R.J.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (residues 1 to 466)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129570.10 and AC154693.2.
            
            On Jun 1, 2023 this sequence version replaced XP_017171289.1.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.1112934.1,
                                           SRR12282455.37550010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     Protein         1..466
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /note="alpha-1A adrenergic receptor; alpha-1A
                     adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic
                     receptor"
                     /calculated_mol_wt=51613
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Region          27..337
                     /region_name="7tmA_alpha1A_AR"
                     /note="alpha-1 adrenergic receptors subtype A, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15325"
                     /db_xref="CDD:320448"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320448"
     Site            28..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          61..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320448"
     Site            65..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          99..129
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320448"
     Site            100..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            order(102,106..107,110..111,178,185,188..189,192,285,
                     288..289,292,308,312,316)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320448"
     Region          141..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320448"
     Site            144..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320448"
     Site            182..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          265..295
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320448"
     Site            274..297
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          305..330
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320448"
     Site            306..329
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          334..349
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     CDS             1..466
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /coded_by="NM_001422096.1:923..2323"
                     /note="isoform 1 is encoded by transcript variant 8"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
ORIGIN      
        1 mvllsenase gsncthppaq vniskaillg vilggliifg vlgnilvils vachrhlhsv
       61 thyyivnlav adllltstvl pfsaifeilg ywafgrvfcn iwaavdvlcc tasimglcii
      121 sidryigvsy plryptivtq rrgvrallcv walslvisig plfgwrqqap edeticqine
      181 epgyvlfsal gsfyvpltii lvmycrvyvv akresrglks glktdksdse qvtlrihrkn
      241 vpaegsgvss aknkthfsvr llkfsrekka aktlgivvgc fvlcwlpffl vmpigsffpn
      301 fkppetvfki vfwlgylnsc inpiiypcss qefkkafqnv lriqclrrrq sskhalgytl
      361 hppsqavegq hrgmvripvg sgetfykisk tdgvrewkff ssmpqgsari tmpkdqsact
      421 tarvrsksfl qvcccvgsst prpeenhqvp tikihtislg engeev
//
LOCUS       NP_001413567             891 aa            linear   ROD 27-AUG-2025
DEFINITION  ras GTPase-activating protein 1 isoform 4 [Mus musculus].
ACCESSION   NP_001413567 XP_011242820
VERSION     NP_001413567.1
DBSOURCE    REFSEQ: accession NM_001426638.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 891)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (residues 1 to 891)
  AUTHORS   Paul,M.E., Chen,D., Vish,K.J., Lartey,N.L., Hughes,E.,
            Freeman,Z.T., Saunders,T.L., Stiegler,A.L., King,P.D. and
            Boggon,T.J.
  TITLE     The C2 domain augments Ras GTPase-activating protein catalytic
            activity
  JOURNAL   Proc Natl Acad Sci U S A 122 (6), e2418433122 (2025)
   PUBMED   39899710
REFERENCE   3  (residues 1 to 891)
  AUTHORS   Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
            Robinson,S.D.
  TITLE     A proteomics approach to isolating neuropilin-dependent alpha5
            integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
            integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells
  JOURNAL   Commun Biol 7 (1), 629 (2024)
   PUBMED   38789481
  REMARK    GeneRIF: A proteomics approach to isolating neuropilin-dependent
            alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
            alpha5 integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 891)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 891)
  AUTHORS   Chen,D., Geng,X., Lapinski,P.E., Davis,M.J., Srinivasan,R.S. and
            King,P.D.
  TITLE     RASA1-driven cellular export of collagen IV is required for the
            development of lymphovenous and venous valves in mice
  JOURNAL   Development 147 (23) (2020)
   PUBMED   33144395
  REMARK    GeneRIF: RASA1-driven cellular export of collagen IV is required
            for the development of lymphovenous and venous valves in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 891)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   7  (residues 1 to 891)
  AUTHORS   Eggen,A., Solinas-Toldo,S., Dietz,A.B., Womack,J.E., Stranzinger,G.
            and Fries,R.
  TITLE     RASA contains a polymorphic microsatellite and maps to bovine
            syntenic group U22 on chromosome 7q2.4-qter
  JOURNAL   Mamm Genome 3 (10), 559-563 (1992)
   PUBMED   1421763
REFERENCE   8  (residues 1 to 891)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   9  (residues 1 to 891)
  AUTHORS   Jenkins,E.P., Hsieh,C.L., Milatovich,A., Normington,K.,
            Berman,D.M., Francke,U. and Russell,D.W.
  TITLE     Characterization and chromosomal mapping of a human steroid 5
            alpha-reductase gene and pseudogene and mapping of the mouse
            homologue
  JOURNAL   Genomics 11 (4), 1102-1112 (1991)
   PUBMED   1686016
REFERENCE   10 (residues 1 to 891)
  AUTHORS   Hsieh,C.L., Vogel,U.S., Dixon,R.A. and Francke,U.
  TITLE     Chromosome localization and cDNA sequence of murine and human genes
            for ras p21 GTPase activating protein (GAP)
  JOURNAL   Somat Cell Mol Genet 15 (6), 579-590 (1989)
   PUBMED   2574500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127316.3.
            
            On Dec 21, 2023 this sequence version replaced XP_011242820.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5159195.1,
                                           SRR14995048.1885077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.05 cM"
     Protein         1..891
                     /product="ras GTPase-activating protein 1 isoform 4"
                     /note="p120-rasGAP; GTPase-activating protein"
                     /calculated_mol_wt=98763
     Region          152..255
                     /region_name="SH2_Nterm_RasGAP"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10353"
                     /db_xref="CDD:198216"
     Site            order(179,198,220,222)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198216"
     Site            order(221,247)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198216"
     Region          272..330
                     /region_name="SH3_RasGAP"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; cd11788"
                     /db_xref="CDD:212722"
     Region          341..417
                     /region_name="SH2_Cterm_RasGAP"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); cd10354"
                     /db_xref="CDD:198217"
     Site            order(349,368,389,391)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198217"
     Site            order(390,417)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198217"
     Region          480..567
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          582..707
                     /region_name="C2_Ras_p21A1"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); cd08400"
                     /db_xref="CDD:176045"
     Region          705..>887
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     CDS             1..891
                     /gene="Rasa1"
                     /gene_synonym="Gap; Rasa; RasGAP"
                     /coded_by="NM_001426638.1:462..3137"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:218397"
                     /db_xref="MGI:MGI:97860"
ORIGIN      
        1 mmaaeagsee ggpatagpgg gaatgssays aacrvklpaa lpvaaapcpg ladadlvaal
       61 gggaasgsgf lgtgpvagvl ggaaltgsaa agvagaaaag pagdvaftkg tlslpaetlg
      121 pgggfpplpp ppqlpplgsg lgtvdegdsl dgpeyeeeev aipltapptn qwyhgkldrt
      181 iaeerlrqag ksgsylires drrpgsfvls flsqtnvvnh friiamcgdy yiggrrfssl
      241 sdligyyshv scllkgekll ypvappepve drrrvrailp ytkvpdtdei sflkgdmfiv
      301 hneledgwmw vtnlrtdeqg livedlveev greedphegk iwfhgkiskq eaynllmtvg
      361 qvcsflvrps dntpgdysly frtneniqrf kicptpnnqf mmggryynsi gdiidhyrke
      421 qivegyylke pvpmqdqgqv lndtvdgkei yntirrktkd afyknivkkg yllkkgkgkr
      481 wknlyfileg sdaqliyfes ekratkpkgl idlsvcsvyv vhdslfgrpn cfqivvqhfs
      541 eehyifyfag etpeqaedwm kglqafcslr ksspgtsnkr lrqvsslvlh ieeahklpvk
      601 hftnpycniy lnsvqvakth aregqnpvws eefvfddlpp dinrfeitls nktkkskdpd
      661 ilfmrcqlsr lqkghatdew fllsshiplk giepgslrvr arysmekimp eeeysefkel
      721 ilqkelhvvy alshvcgqdr tllasillki flheklesll lctlndreis medeattlfr
      781 attlastlme qymkatatqf vhhalkdsil kimeskqsce lspsklekne dvntnlahll
      841 silselveki fmaseilppt lryiygclqk svqhkwptnn tmrtrvvrqn v
//
LOCUS       NP_034991                166 aa            linear   ROD 27-AUG-2025
DEFINITION  myosin regulatory light chain 2, ventricular/cardiac muscle isoform
            isoform 1 [Mus musculus].
ACCESSION   NP_034991
VERSION     NP_034991.3
DBSOURCE    REFSEQ: accession NM_010861.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 166)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 166)
  AUTHORS   Xu,F., Huang,H., Peng,K., Jian,C., Wu,H., Jing,Z., Qiu,S., Chen,Y.,
            Liu,K., Fu,L., Wang,Y., Yang,J., Duan,X., Wang,C., Cheng,H. and
            Wang,X.
  TITLE     ROMO1 overexpression protects the mitochondrial cysteinome from
            oxidations in aging
  JOURNAL   Nat Commun 16 (1), 5133 (2025)
   PUBMED   40461459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 166)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 166)
  AUTHORS   Yu,Z., Zhang,S., Bogomolovas,J., Chen,J. and Evans,S.M.
  TITLE     Intronic RNAscope probes enable precise identification of
            cardiomyocyte nuclei and cell cycle activity
  JOURNAL   Commun Biol 8 (1), 577 (2025)
   PUBMED   40195462
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 166)
  AUTHORS   Sheikh,F., Lyon,R.C. and Chen,J.
  TITLE     Functions of myosin light chain-2 (MYL2) in cardiac muscle and
            disease
  JOURNAL   Gene 569 (1), 14-20 (2015)
   PUBMED   26074085
  REMARK    Review article
            Erratum:[Gene. 2015 Oct 15;571(1):151]
REFERENCE   6  (residues 1 to 166)
  AUTHORS   Lee,K.F., Simon,H., Chen,H., Bates,B., Hung,M.C. and Hauser,C.
  TITLE     Requirement for neuregulin receptor erbB2 in neural and cardiac
            development
  JOURNAL   Nature 378 (6555), 394-398 (1995)
   PUBMED   7477377
REFERENCE   7  (residues 1 to 166)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   8  (residues 1 to 166)
  AUTHORS   Lee,K.J., Ross,R.S., Rockman,H.A., Harris,A.N., O'Brien,T.X., van
            Bilsen,M., Shubeita,H.E., Kandolf,R., Brem,G., Price,J. et al.
  TITLE     Myosin light chain-2 luciferase transgenic mice reveal distinct
            regulatory programs for cardiac and skeletal muscle-specific
            expression of a single contractile protein gene
  JOURNAL   J Biol Chem 267 (22), 15875-15885 (1992)
   PUBMED   1379240
REFERENCE   9  (residues 1 to 166)
  AUTHORS   Hastings,K.E. and Emerson,C.P. Jr.
  TITLE     cDNA clone analysis of six co-regulated mRNAs encoding skeletal
            muscle contractile proteins
  JOURNAL   Proc Natl Acad Sci U S A 79 (5), 1553-1557 (1982)
   PUBMED   6951196
REFERENCE   10 (residues 1 to 166)
  AUTHORS   Czosnek,H., Nudel,U., Shani,M., Barker,P.E., Pravtcheva,D.D.,
            Ruddle,F.H. and Yaffe,D.
  TITLE     The genes coding for the muscle contractile proteins, myosin heavy
            chain, myosin light chain 2, and skeletal muscle actin are located
            on three different mouse chromosomes
  JOURNAL   EMBO J 1 (11), 1299-1305 (1982)
   PUBMED   6897916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140353.2, AK002367.1 and BX529018.1.
            
            On Jul 25, 2007 this sequence version replaced NP_034991.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061144.1, AK002367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     Protein         1..166
                     /product="myosin regulatory light chain 2,
                     ventricular/cardiac muscle isoform isoform 1"
                     /note="myosin light chain 2v; myosin light chain,
                     phosphorylatable, cardiac ventricles"
                     /calculated_mol_wt=18733
     Site            2
                     /site_type="methylation"
                     /note="N,N,N-trimethylalanine.
                     /evidence=ECO:0000269|PubMed:20668449; propagated from
                     UniProtKB/Swiss-Prot (P51667.3)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MLCK.
                     /evidence=ECO:0000269|PubMed:20445002,
                     ECO:0000269|PubMed:22426213, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P51667.3)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MLCK.
                     /evidence=ECO:0000269|PubMed:20445002,
                     ECO:0000269|PubMed:22426213, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P51667.3)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:22426213,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P51667.3)"
     Region          20..160
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P08733; propagated from
                     UniProtKB/Swiss-Prot (P51667.3)"
     CDS             1..166
                     /gene="Myl2"
                     /gene_synonym="Gm32672; MLC-2; MLC-2s/v; MLC-2v; Mlc2v;
                     Mylpc"
                     /coded_by="NM_010861.4:77..577"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39252.1"
                     /db_xref="GeneID:17906"
                     /db_xref="MGI:MGI:97272"
ORIGIN      
        1 mapkkakkri eggssnvfsm feqtqiqefk eaftimdqnr dgfidkndlr dtfaalgrvn
       61 vkneeidemi keapgpinft vfltmfgekl kgadpeetil nafkvfdpeg kgslkadyvr
      121 emlttqaerf skeeidqmfa afppdvtgnl dyknlvhiit hgeekd
//
LOCUS       NP_001334648             790 aa            linear   ROD 27-AUG-2025
DEFINITION  platelet-derived growth factor receptor alpha isoform 2 precursor
            [Mus musculus].
ACCESSION   NP_001334648
VERSION     NP_001334648.1
DBSOURCE    REFSEQ: accession NM_001347719.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 790)
  AUTHORS   Tran,L.N., Shinde,A., Schuster,K.H., Sabaawy,A., Dale,E.,
            Welch,M.J., Isner,T.J., Nunez,S.A., Garcia-Moreno,F.,
            Sagerstrom,C.G., Appel,B.H. and Franco,S.J.
  TITLE     Epigenetic priming of neural progenitors by Notch enhances Sonic
            hedgehog signaling and establishes gliogenic competence
  JOURNAL   Genes Dev 39 (13-14), 886-906 (2025)
   PUBMED   40404401
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 790)
  AUTHORS   Summers,B.S., Blizzard,C.A., Ricci,R.R., Pitman,K.A., Dempsey,B.,
            McMullan,S., Sutherland,B.A., Young,K.M. and Cullen,C.L.
  TITLE     Demyelination Produces a Shift in the Population of Cortical
            Neurons That Synapse with Callosal Oligodendrocyte Progenitor Cells
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40345851
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 790)
  AUTHORS   Van Hove,H., Gluck,C., Mildenberger,W., Petrova,E., Maheshwari,U.,
            Hane,P., Kreiner,V., Bijnen,M., Mussak,C., Utz,S.G., Droux,J.,
            Ingelfinger,F., Ashworth,C., Stifter,S.A., Roussel,E., Lelios,I.,
            Vermeer,M., Huang,S.F., Zhou,Q., Chen,Z., Calvet,C., Bourgeois,S.,
            Schaffenrath,J., Razansky,D., Juang,J.X., Asano,K., Pelczar,P.,
            Mundt,S., Weber,B., Wegener,S., Tugues,S., Stockmann,C., Becher,B.,
            Keller,A., El Amki,M. and Greter,M.
  TITLE     Interleukin-34-dependent perivascular macrophages promote vascular
            function in the brain
  JOURNAL   Immunity 58 (5), 1289-1305 (2025)
   PUBMED   40315842
REFERENCE   4  (residues 1 to 790)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 790)
  AUTHORS   Mueller,A.A., van Velthoven,C.T., Fukumoto,K.D., Cheung,T.H. and
            Rando,T.A.
  TITLE     Intronic polyadenylation of PDGFRalpha in resident stem cells
            attenuates muscle fibrosis
  JOURNAL   Nature 540 (7632), 276-279 (2016)
   PUBMED   27894125
  REMARK    GeneRIF: polyadenylation of a PDGFRalpha intron in resident stem
            cells attenuates muscle fibrosis
REFERENCE   6  (residues 1 to 790)
  AUTHORS   Demoulin,J.B. and Essaghir,A.
  TITLE     PDGF receptor signaling networks in normal and cancer cells
  JOURNAL   Cytokine Growth Factor Rev 25 (3), 273-283 (2014)
   PUBMED   24703957
  REMARK    Review article
REFERENCE   7  (residues 1 to 790)
  AUTHORS   Palmieri,S.L., Payne,J., Stiles,C.D., Biggers,J.D. and Mercola,M.
  TITLE     Expression of mouse PDGF-A and PDGF alpha-receptor genes during
            pre- and post-implantation development: evidence for a
            developmental shift from an autocrine to a paracrine mode of action
  JOURNAL   Mech Dev 39 (3), 181-191 (1992)
   PUBMED   1292572
REFERENCE   8  (residues 1 to 790)
  AUTHORS   Do,M.S., Fitzer-Attas,C., Gubbay,J., Greenfeld,L., Feldman,M. and
            Eisenbach,L.
  TITLE     Mouse platelet-derived growth factor alpha receptor: sequence,
            tissue-specific expression and correlation with metastatic
            phenotype
  JOURNAL   Oncogene 7 (8), 1567-1575 (1992)
   PUBMED   1321404
REFERENCE   9  (residues 1 to 790)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   10 (residues 1 to 790)
  AUTHORS   Truslove,G.M.
  TITLE     A new allele at the patch locus in the mouse
  JOURNAL   Genet Res 29 (2), 183-186 (1977)
   PUBMED   863250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120348.9, AK081664.1 and
            AK147267.1.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins. Binding of platelet-derived growth factor
            protein ligands to this receptor triggers receptor dimerization and
            autophosphorylation, resulting in the activation of several
            downstream signaling pathways. Signaling through the encoded
            receptor plays a role in gastrulation and the development of nearly
            all organ systems. Mice lacking a functional copy of this gene
            reportedly exhibit defects in lung, skeleton, testis and the
            central nervous system, and die soon after birth. Alternative
            splicing and intronic polyadenylation of gene transcripts have been
            implicated in muscle regeneration and fibrosis in adult mice.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and its
            3' terminal exon extends past a splice site that is used in variant
            1, which results in a novel 3' coding region and 3' UTR, compared
            to variant 1. The encoded isoform (2, also known as
            'In-PDGFRalpha') is shorter and has a distinct C-terminus compared
            to isoform 1. Both variants 3 and 4 encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145097.1, SRR7652917.1123233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     Protein         1..790
                     /product="platelet-derived growth factor receptor alpha
                     isoform 2 precursor"
                     /EC_number="2.7.10.1"
                     /note="alpha-type platelet-derived growth factor receptor;
                     platelet-derived growth factor receptor alpha;
                     PDGF-R-alpha; CD140 antigen-like family member A; PDGF
                     alpha chain; Alpha platelet-derived growth factor receptor
                     precursor (PDGF-R-alpha); PDGFR-alpha"
                     /calculated_mol_wt=86143
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
                     /calculated_mol_wt=2505
     Region          28..100
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            42
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            76
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            103
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            179
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Region          212..310
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          231..235
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          244..248
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          273..277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          302..305
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          313..413
                     /region_name="Ig4_PDGFR"
                     /note="Fourth immunoglobulin (Ig)-like domain of
                     platelet-derived growth factor receptor (PDGFR); cd05859"
                     /db_xref="CDD:409445"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            359
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            458
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            468
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            506
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            529..549
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Region          555..>772
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            574
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234, ECO:0000305;
                     propagated from UniProtKB/Swiss-Prot (P26618.3)"
     Site            731
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            754
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            762
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     Site            768
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P16234; propagated from
                     UniProtKB/Swiss-Prot (P26618.3)"
     CDS             1..790
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /coded_by="NM_001347719.1:776..3148"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS89929.1"
                     /db_xref="GeneID:18595"
                     /db_xref="MGI:MGI:97530"
ORIGIN      
        1 mgtshqvflv lsclltgpgl iscqlllpsi lpnenekivq lnssfslrcv gesevswqhp
       61 mseeddpnve irseennsgl fvtvlevvna saahtgwytc yynhtqtdes eiegrhiyiy
      121 vpdpdmafvp lgmtdslviv eeddsaiipc rttdpetqvt lhnngrlvpa sydsrqgfng
      181 tfsvgpyice atvkgrtfkt sefnvyalka tselnlemda rqtvykaget ivvtcavfnn
      241 evvdlqwtyp gevrnkgitm leeiklpsik lvytltvpka tvkdsgeyec aarqatkevk
      301 emkrvtisvh ekgfveiept fgqleavnlh evrefvvevq ayptpriswl kdnltlienl
      361 teittdvqks qetryqsklk lirakeedsg hytiivqned dvksytfels tlvpasildl
      421 vddhhgsggg qtvrctaegt plpeidwmic khikkcnndt swtvlasnvs niitelprrg
      481 rstvegrvsf akveetiavr claknnlsvv arelklvapt lrseltvaaa vlvllviviv
      541 slivlvviwk qkpryeirwr viesispdgh eyiyvdpmql pydsrwefpr dglvlgrilg
      601 sgafgkvveg tayglsrsqp vmkvavkmlk ptarssekqa lmselkimth lgphlnivnl
      661 lgactksgpi yiiteycfyg dlvnylhknr dsfmsqhpek pkkdldifgl npadestrsy
      721 vilsfenngd ymdmkqadtt qyvpmlerke vskysdiqrs lydrpasykk ksmlgksaha
      781 hsgkydlsvv
//
LOCUS       NP_001258727            1203 aa            linear   ROD 27-AUG-2025
DEFINITION  protocadherin-9 isoform b precursor [Mus musculus].
ACCESSION   NP_001258727
VERSION     NP_001258727.1
DBSOURCE    REFSEQ: accession NM_001271798.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1203)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1203)
  AUTHORS   Miozzo,F., Murru,L., Maiellano,G., di Iasio,I., Zippo,A.G.,
            Zambrano Avendano,A., Metodieva,V.D., Riccardi,S., D'Aliberti,D.,
            Spinelli,S., Canu,T., Chaabane,L., Hirano,S., Kas,M.J.H.,
            Francolini,M., Piazza,R., Moretto,E. and Passafaro,M.
  TITLE     Disruption of the autism-associated Pcdh9 gene leads to
            transcriptional alterations, synapse overgrowth, and defective
            network activity in the CA1
  JOURNAL   J Neurosci 44 (50) (2024) In press
   PUBMED   39557582
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 1203)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1203)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (residues 1 to 1203)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   6  (residues 1 to 1203)
  AUTHORS   Kirchhof,P., Kahr,P.C., Kaese,S., Piccini,I., Vokshi,I.,
            Scheld,H.H., Rotering,H., Fortmueller,L., Laakmann,S., Verheule,S.,
            Schotten,U., Fabritz,L. and Brown,N.A.
  TITLE     PITX2c is expressed in the adult left atrium, and reducing Pitx2c
            expression promotes atrial fibrillation inducibility and complex
            changes in gene expression
  JOURNAL   Circ Cardiovasc Genet 4 (2), 123-133 (2011)
   PUBMED   21282332
REFERENCE   7  (residues 1 to 1203)
  AUTHORS   Krishna-K,K., Hertel,N. and Redies,C.
  TITLE     Cadherin expression in the somatosensory cortex: evidence for a
            combinatorial molecular code at the single-cell level
  JOURNAL   Neuroscience 175, 37-48 (2011)
   PUBMED   21129452
REFERENCE   8  (residues 1 to 1203)
  AUTHORS   Vanhalst,K., Kools,P., Staes,K., van Roy,F. and Redies,C.
  TITLE     delta-Protocadherins: a gene family expressed differentially in the
            mouse brain
  JOURNAL   Cell Mol Life Sci 62 (11), 1247-1259 (2005)
   PUBMED   15905963
REFERENCE   9  (residues 1 to 1203)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   10 (residues 1 to 1203)
  AUTHORS   Strehl,S., Glatt,K., Liu,Q.M., Glatt,H. and Lalande,M.
  TITLE     Characterization of two novel protocadherins (PCDH8 and PCDH9)
            localized on human chromosome 13 and mouse chromosome 14
  JOURNAL   Genomics 53 (1), 81-89 (1998)
   PUBMED   9787079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC132470.3, AC125095.3 and
            AC123919.4.
            
            Summary: This gene encodes a member of the protocadherin family,
            and cadherin superfamily, of transmembrane proteins containing
            cadherin domains. These proteins mediate cell adhesion in neural
            tissues in the presence of calcium. The encoded protein may be
            involved in signaling at neuronal synaptic junctions. Sharing a
            characteristic with other protocadherin genes, this gene has a
            notably large exon that encodes multiple cadherin domains and a
            transmembrane region. Alternatively spliced transcript variants
            encoding multiple isoforms have been observed for this gene.
            [provided by RefSeq, Nov 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an in-frame exon, compared to variant 1. The encoded isoform
            (b, also known as 2) is shorter than isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147451.1, SRR1660821.60944.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 45.8 cM"
     Protein         1..1203
                     /product="protocadherin-9 isoform b precursor"
                     /calculated_mol_wt=129737
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2568
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1203
                     /gene="Pcdh9"
                     /coded_by="NM_001271798.1:706..4317"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS79350.1"
                     /db_xref="GeneID:211712"
                     /db_xref="MGI:MGI:1306801"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf nreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtded
      601 agenkavtls ilndnenfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdidtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkalhtlvlv flyvndtagn
      781 tsyiydlirr tmetpldrni gdsgqpyqne dyltimiaiv agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqgigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqsqrrvtfh
     1021 lpdgsqescs dsglgdhepv gsgtlishpl plvqpqdefy dqaspdkrte adgnsdpnsd
     1081 gplgprglae atemctqecl vlghsdncwm ppglgpyqhp ksplstfapq kewikkdklv
     1141 nghtltrawk edtnrnqfnd rkqygsnegh fnngghmadi planlksykq aggtiespke
     1201 hql
//
LOCUS       NP_001415305             158 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 7 [Mus musculus].
ACCESSION   NP_001415305
VERSION     NP_001415305.1
DBSOURCE    REFSEQ: accession NM_001428376.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 158)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 158)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 158)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 158)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 158)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 158)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 158)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 158)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 158)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 158)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862062.139090.1,
                                           SRR17253014.2769846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..158
                     /product="autophagy protein 5 isoform 7"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=17870
     Region          1..>111
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..158
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001428376.1:350..826"
                     /note="isoform 7 is encoded by transcript variant 8"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mhypigllfd llasssalpw nitvhfksfp ekdllhcpsk daveahfmsc mkeadalkhk
       61 sqvinemqkk dhkqlwmglq ndltsfgpst gnswnilqkk mdfvispley irprrsglss
      121 rscsglwpqm dscthleiss eksvlpqspl kmerrgar
//
LOCUS       NP_001292545             136 aa            linear   ROD 27-AUG-2025
DEFINITION  calcitonin gene-related peptide 1 isoform Calca preproprotein [Mus
            musculus].
ACCESSION   NP_001292545
VERSION     NP_001292545.1
DBSOURCE    REFSEQ: accession NM_001305616.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 136)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 136)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 136)
  AUTHORS   Santiago,C., Siegrist,J., Africawala,N., Handler,A., Tasnim,A.,
            Anjum,R., Turecek,J., Lehnert,B.P., Renauld,S., Choi,J.,
            Nolan-Tamariz,M., Iskols,M., Magee,A.R., Paradis,S., Sharma,N. and
            Ginty,D.D.
  TITLE     Activity-dependent development of the body's touch receptors
  JOURNAL   Neuron 113 (11), 1758-1773 (2025)
   PUBMED   40381613
REFERENCE   4  (residues 1 to 136)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   5  (residues 1 to 136)
  AUTHORS   Zhi,X., Wu,F., Qian,J., Ochiai,Y., Lian,G., Malagola,E., Zheng,B.,
            Tu,R., Zeng,Y., Kobayashi,H., Xia,Z., Wang,R., Peng,Y., Shi,Q.,
            Chen,D., Ryeom,S.W. and Wang,T.C.
  TITLE     Nociceptive neurons promote gastric tumour progression via a
            CGRP-RAMP1 axis
  JOURNAL   Nature 640 (8059), 802-810 (2025)
   PUBMED   39972142
REFERENCE   6  (residues 1 to 136)
  AUTHORS   Ahren,B. and Sundler,F.
  TITLE     Localization of calcitonin gene-related peptide and islet amyloid
            polypeptide in the rat and mouse pancreas
  JOURNAL   Cell Tissue Res 269 (2), 315-322 (1992)
   PUBMED   1423499
REFERENCE   7  (residues 1 to 136)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   8  (residues 1 to 136)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   9  (residues 1 to 136)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   10 (residues 1 to 136)
  AUTHORS   Lalley,P.A., Sakaguchi,A.Y., Eddy,R.L., Honey,N.H., Bell,G.I.,
            Shen,L.P., Rutter,W.J., Jacobs,J.W., Heinrich,G., Chin,W.W. et al.
  TITLE     Mapping polypeptide hormone genes in the mouse: somatostatin,
            glucagon, calcitonin, and parathyroid hormone
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 92-97 (1987)
   PUBMED   2882956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ060164.1, AK132582.1,
            AC156617.9 and BC030071.1.
            
            Summary: This gene encodes the peptide hormones calcitonin,
            calcitonin gene-related peptide (CGRP) and katacalcin. Alternative
            splicing of the mRNA results in multiple variants that encode
            either calcitonin or CGRP preproproteins. Post-translational
            processing of the calcitonin and CGRP propeptides results in either
            calcitonin and katacalcin, or CGRP, respectively. Calcitonin and
            katacalcin modulate calcium levels in the blood stream. CGRP can
            function as a vasodilator and play a role in the transmission of
            pain. The human homolog of CGRP was found to have antimicrobial
            activity. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 4 encode the same isoform Calca.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK792741.1, CK796415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..136
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.99 cM"
     Protein         1..136
                     /product="calcitonin gene-related peptide 1 isoform Calca
                     preproprotein"
                     /note="alpha-type CGRP; calcitonin gene-related peptide I"
                     /calculated_mol_wt=12370
     Region          1..120
                     /region_name="Calc_CGRP_IAPP"
                     /note="Calcitonin / CGRP / IAPP family; pfam00214"
                     /db_xref="CDD:459715"
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P01257; propagated from
                     UniProtKB/Swiss-Prot (P70160.1)"
     Region          63..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70160.1)"
     mat_peptide     85..116
                     /product="Calcitonin. /id=PRO_0000004057"
                     /note="propagated from UniProtKB/Swiss-Prot (P70160.1)"
                     /calculated_mol_wt=3475
     Site            87
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P70160.1)"
     Region          114..136
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70160.1)"
     Site            116
                     /site_type="amidation"
                     /note="Proline amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P70160.1)"
     CDS             1..136
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /coded_by="NM_001305616.1:180..590"
                     /note="isoform Calca preproprotein is encoded by
                     transcript variant 4"
                     /db_xref="CCDS:CCDS21763.1"
                     /db_xref="GeneID:12310"
                     /db_xref="MGI:MGI:2151253"
ORIGIN      
        1 mgflkfspfl vvsilllyqa cslqavplrs ilesspgmat lseeevrlla alvqdymqmk
       61 areleqeeeq eaegssldsp rskrcgnlst cmlgtytqdl nkfhtfpqts igveapgkkr
      121 dvakdletnh qshfgn
//
LOCUS       NP_034394                495 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor subfamily 6 group A member 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_034394
VERSION     NP_034394.1
DBSOURCE    REFSEQ: accession NM_010264.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Neelathi,U.M., Ullah,E., George,A., Maftei,M.I., Boobalan,E.,
            Sanchez-Mendoza,D., Adams,C., McGaughey,D., Sergeev,Y.V., Ai
            Rawi,R., Naik,A., Bender,C., Maumenee,I.H., Michaelides,M.,
            Tan,T.G., Lin,S., Villasmil,R., Blain,D., Hufnagel,R.B., Arno,G.,
            Young,R.M., Guan,B. and Brooks,B.P.
  TITLE     Variants in NR6A1 cause a novel oculo vertebral renal syndrome
  JOURNAL   Nat Commun 16 (1), 6111 (2025)
   PUBMED   40610405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Chang,Y.C., Manent,J., Schroeder,J., Wong,S.F.L., Hauswirth,G.M.,
            Shylo,N.A., Moore,E.L., Achilleos,A., Garside,V., Polo,J.M.,
            Trainor,P. and McGlinn,E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Tan,P., Xue,T., Wang,Y., Hu,Z., Su,J., Yang,R., Ji,J., Ye,M.,
            Chen,Z., Huang,C. and Lu,X.
  TITLE     Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the
            development of depression-like behaviors in mice
  JOURNAL   Neuropharmacology 209, 108990 (2022)
   PUBMED   35183538
  REMARK    GeneRIF: Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to
            the development of depression-like behaviors in mice.
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Koutelou,E., Wang,L., Schibler,A.C., Chao,H.P., Kuang,X., Lin,K.,
            Lu,Y., Shen,J., Jeter,C.R., Salinger,A., Wilson,M., Chen,Y.C.,
            Atanassov,B.S., Tang,D.G. and Dent,S.Y.R.
  TITLE     USP22 controls multiple signaling pathways that are essential for
            vasculature formation in the mouse placenta
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30718289
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Kapelle,M., Kratzschmar,J., Husemann,M. and Schleuning,W.D.
  TITLE     cDNA cloning of two closely related forms of human germ cell
            nuclear factor (GCNF)
  JOURNAL   Biochim Biophys Acta 1352 (1), 13-17 (1997)
   PUBMED   9177477
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Yan,Z.H., Medvedev,A., Hirose,T., Gotoh,H. and Jetten,A.M.
  TITLE     Characterization of the response element and DNA binding properties
            of the nuclear orphan receptor germ cell nuclear factor/retinoid
            receptor-related testis-associated receptor
  JOURNAL   J Biol Chem 272 (16), 10565-10572 (1997)
   PUBMED   9099702
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Joos,T.O., David,R. and Dreyer,C.
  TITLE     xGCNF, a nuclear orphan receptor is expressed during neurulation in
            Xenopus laevis
  JOURNAL   Mech Dev 60 (1), 45-57 (1996)
   PUBMED   9025060
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Hirose,T., O'Brien,D.A. and Jetten,A.M.
  TITLE     RTR: a new member of the nuclear receptor superfamily that is
            highly expressed in murine testis
  JOURNAL   Gene 152 (2), 247-251 (1995)
   PUBMED   7835709
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935155.13 and AL844842.29.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14666.1, AF390896.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     Protein         1..495
                     /product="nuclear receptor subfamily 6 group A member 1
                     isoform 1"
                     /note="mGCNF; retinoid receptor-related testis-specific
                     receptor; germ cell nuclear factor"
                     /calculated_mol_wt=55845
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     Region          67..156
                     /region_name="NR_DBD_GCNF_like"
                     /note="DNA-binding domain of Germ cell nuclear factor
                     (GCNF) F1 is composed of two C4-type zinc fingers;
                     cd07169"
                     /db_xref="CDD:143543"
     Site            order(75,78,92,95,111,117,127,130)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143543"
     Site            order(85..87,93..94,96,98,101,104,124..125,128,131,142,
                     145)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143543"
     Region          145..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     Region          177..214
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     Region          187..268
                     /region_name="Sufficient for interaction with UIMC1.
                     /evidence=ECO:0000269|PubMed:7760852"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64249.1)"
     Region          271..482
                     /region_name="NR_LBD_DHR4_like"
                     /note="The ligand binding domain of orphan nuclear
                     receptor Ecdysone-induced receptor DHR4; cd06953"
                     /db_xref="CDD:132751"
     Site            order(301..302,306,340,344,347,361,384)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:132751"
     Site            order(311,314,318,323,328..329,331..332,335..336)
                     /site_type="active"
                     /note="putative coactivator recognition site [active]"
                     /db_xref="CDD:132751"
     CDS             1..495
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /coded_by="NM_010264.5:203..1690"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16012.1"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
ORIGIN      
        1 merderppsg ggggggsagf leppaalppp prngfcqdel aeldpgtnge tdsltlgqgh
       61 ipvsvpddra eqrtclicgd ratglhygii scegckgffk rsicnkrvyr csrdkncvms
      121 rkqrnrcqyc rllkclqmgm nrkairedgm pggrnksigp vqiseeeier imsgqefeee
      181 anhwsnhgds dhsspgnras esnqpspgst lsssrsveln gfmafrdqym gmsvpphyqy
      241 iphlfsysgh spllppqars ldpqsyslih qlmsaedlep lgtpmliedg yavtqaelfa
      301 llcrladell frqiawikkl pffcelsikd ytcllsstwq elillssltv yskqifgela
      361 dvtakyspsd eelhrfsdeg mevierliyl yhkfhqlkvs neeyacmkai nflnqdirgl
      421 tsasqleqln krywyicqdf teykythqpn rfpdlmmclp eiryiagkmv nvpleqlpll
      481 fkvvlhsckt stvke
//
LOCUS       NP_001258689             466 aa            linear   ROD 27-AUG-2025
DEFINITION  alpha-1A adrenergic receptor isoform 1 [Mus musculus].
ACCESSION   NP_001258689
VERSION     NP_001258689.1
DBSOURCE    REFSEQ: accession NM_001271760.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 466)
  AUTHORS   Gural,B., Kirkland,L., Hockett,A., Sandroni,P., Zhang,J.,
            Rosa-Garrido,M., Swift,S.K., Chapski,D.J., Flinn,M.A.,
            O'Meara,C.C., Vondriska,T.M., Patterson,M., Jensen,B.C. and
            Rau,C.D.
  TITLE     Novel insights into post-myocardial infarction cardiac remodeling
            through algorithmic detection of cell-type composition shifts
  JOURNAL   PLoS Genet 21 (7), e1011807 (2025)
   PUBMED   40705823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 466)
  AUTHORS   Heo,E.Y., Salinas-Birt,A., Ye,L., Sajadi,S., Sarker,M.K., Yang,Y.
            and Paukert,M.
  TITLE     Impaired neuromodulator crosstalk delays arousal-dependent
            astroglia Ca2+ activation in mouse models of Alzheimer's disease
  JOURNAL   iScience 28 (8), 113120 (2025)
   PUBMED   40777052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 466)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   4  (residues 1 to 466)
  AUTHORS   Docherty,J.R.
  TITLE     Subtypes of functional alpha1-adrenoceptor
  JOURNAL   Cell Mol Life Sci 67 (3), 405-417 (2010)
   PUBMED   19862476
  REMARK    Review article
REFERENCE   5  (residues 1 to 466)
  AUTHORS   Lin,F., Owens,W.A., Chen,S., Stevens,M.E., Kesteven,S.,
            Arthur,J.F., Woodcock,E.A., Feneley,M.P. and Graham,R.M.
  TITLE     Targeted alpha(1A)-adrenergic receptor overexpression induces
            enhanced cardiac contractility but not hypertrophy
  JOURNAL   Circ Res 89 (4), 343-350 (2001)
   PUBMED   11509451
REFERENCE   6  (residues 1 to 466)
  AUTHORS   O'Connell,T.D., Rokosh,D.G. and Simpson,P.C.
  TITLE     Cloning and characterization of the mouse alpha1C/A-adrenergic
            receptor gene and analysis of an alpha1C promoter in cardiac
            myocytes: role of an MCAT element that binds transcriptional
            enhancer factor-1 (TEF-1)
  JOURNAL   Mol Pharmacol 59 (5), 1225-1234 (2001)
   PUBMED   11306707
REFERENCE   7  (residues 1 to 466)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (residues 1 to 466)
  AUTHORS   Xiao,L., Scofield,M.A. and Jeffries,W.B.
  TITLE     Molecular cloning, expression and characterization of cDNA encoding
            a mouse alpha1a-adrenoceptor
  JOURNAL   Br J Pharmacol 124 (1), 213-221 (1998)
   PUBMED   9630362
REFERENCE   9  (residues 1 to 466)
  AUTHORS   Rockman,H.A., Koch,W.J. and Lefkowitz,R.J.
  TITLE     Cardiac function in genetically engineered mice with altered
            adrenergic receptor signaling
  JOURNAL   Am J Physiol 272 (4 Pt 2), H1553-H1559 (1997)
   PUBMED   9139936
  REMARK    Review article
REFERENCE   10 (residues 1 to 466)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Casanova,E., Ovalle,S.,
            Calvo,P. and Chinchetru,M.A.
  TITLE     Molecular cloning of alpha 1d-adrenergic receptor and tissue
            distribution of three alpha 1-adrenergic receptor subtypes in mouse
  JOURNAL   J Neurochem 65 (6), 2387-2392 (1995)
   PUBMED   7595531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129570.10 and AC154693.2.
            
            Summary: This gene encodes one of several multipass transmembrane
            proteins that function as G protein-coupled receptors. The encoded
            protein binds to epinephrine and norepinephrine to mediate
            signaling in cells of the cardiac, nervous, and other organ
            systems. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     Protein         1..466
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /note="alpha-1A adrenergic receptor; alpha-1A
                     adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic
                     receptor"
                     /calculated_mol_wt=51613
     Site            7
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P97718.3)"
     Region          27..337
                     /region_name="7tmA_alpha1A_AR"
                     /note="alpha-1 adrenergic receptors subtype A, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15325"
                     /db_xref="CDD:320448"
     Region          28..54
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320448"
     Site            28..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          61..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320448"
     Site            65..88
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          99..129
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320448"
     Site            100..122
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            order(102,106..107,110..111,178,185,188..189,192,285,
                     288..289,292,308,312,316)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320448"
     Region          141..164
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320448"
     Site            144..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320448"
     Site            182..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          265..295
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320448"
     Site            274..297
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          305..330
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320448"
     Site            306..329
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     Region          334..349
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P97718.3)"
     CDS             1..466
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /coded_by="NM_001271760.2:450..1850"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS27223.1"
                     /db_xref="GeneID:11549"
                     /db_xref="MGI:MGI:104773"
ORIGIN      
        1 mvllsenase gsncthppaq vniskaillg vilggliifg vlgnilvils vachrhlhsv
       61 thyyivnlav adllltstvl pfsaifeilg ywafgrvfcn iwaavdvlcc tasimglcii
      121 sidryigvsy plryptivtq rrgvrallcv walslvisig plfgwrqqap edeticqine
      181 epgyvlfsal gsfyvpltii lvmycrvyvv akresrglks glktdksdse qvtlrihrkn
      241 vpaegsgvss aknkthfsvr llkfsrekka aktlgivvgc fvlcwlpffl vmpigsffpn
      301 fkppetvfki vfwlgylnsc inpiiypcss qefkkafqnv lriqclrrrq sskhalgytl
      361 hppsqavegq hrgmvripvg sgetfykisk tdgvrewkff ssmpqgsari tmpkdqsact
      421 tarvrsksfl qvcccvgsst prpeenhqvp tikihtislg engeev
//
LOCUS       NP_001157848             895 aa            linear   ROD 27-AUG-2025
DEFINITION  catenin alpha-3 isoform 1 [Mus musculus].
ACCESSION   NP_001157848
VERSION     NP_001157848.1
DBSOURCE    REFSEQ: accession NM_001164376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 895)
  AUTHORS   Li,X., Sun,W., Xu,X., Jiang,Q., Shi,Y., Zhang,H., Yu,W., Shi,B.,
            Wan,S., Liu,J., Song,W., Zhang,J., Yuan,Z. and Li,J.
  TITLE     Hepatitis B virus surface antigen drives T cell immunity through
            non-canonical antigen presentation in mice
  JOURNAL   Nat Commun 16 (1), 4591 (2025)
   PUBMED   40382385
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 895)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
REFERENCE   3  (residues 1 to 895)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   4  (residues 1 to 895)
  AUTHORS   Weng,A., Rabin,E.E., Flozak,A.S., Chiarella,S.E., Aillon,R.P. and
            Gottardi,C.J.
  TITLE     Alpha-T-catenin is expressed in peripheral nerves as a constituent
            of Schwann cell adherens junctions
  JOURNAL   Biol Open 11 (12) (2022)
   PUBMED   36420826
  REMARK    GeneRIF: Alpha-T-catenin is expressed in peripheral nerves as a
            constituent of Schwann cell adherens junctions.
REFERENCE   5  (residues 1 to 895)
  AUTHORS   Zhang,Y.
  TITLE     SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells
  JOURNAL   Cell Tissue Res 389 (1), 145-157 (2022)
   PUBMED   35536443
  REMARK    GeneRIF: SPATA33 affects the formation of cell adhesion complex by
            interacting with CTNNA3 in TM4 cells.
REFERENCE   6  (residues 1 to 895)
  AUTHORS   Goossens,S., Janssens,B., Bonne,S., De Rycke,R., Braet,F., van
            Hengel,J. and van Roy,F.
  TITLE     A unique and specific interaction between alphaT-catenin and
            plakophilin-2 in the area composita, the mixed-type junctional
            structure of cardiac intercalated discs
  JOURNAL   J Cell Sci 120 (Pt 12), 2126-2136 (2007)
   PUBMED   17535849
  REMARK    GeneRIF: By providing an extra link between the cadherin-catenin
            complex and intermediate filaments, the binding of alphaT-catenin
            to plakophilin-2 is proposed to be a means of modulating and
            strengthening cell-cell adhesion between cardiac muscle cells.
REFERENCE   7  (residues 1 to 895)
  AUTHORS   Goossens,S., Janssens,B., Vanpoucke,G., De Rycke,R., van Hengel,J.
            and van Roy,F.
  TITLE     Truncated isoform of mouse alphaT-catenin is testis-restricted in
            expression and function
  JOURNAL   FASEB J 21 (3), 647-655 (2007)
   PUBMED   17185752
REFERENCE   8  (residues 1 to 895)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   9  (residues 1 to 895)
  AUTHORS   Janssens,B., Mohapatra,B., Vatta,M., Goossens,S., Vanpoucke,G.,
            Kools,P., Montoye,T., van Hengel,J., Bowles,N.E., van Roy,F. and
            Towbin,J.A.
  TITLE     Assessment of the CTNNA3 gene encoding human alpha T-catenin
            regarding its involvement in dilated cardiomyopathy
  JOURNAL   Hum Genet 112 (3), 227-236 (2003)
   PUBMED   12596047
REFERENCE   10 (residues 1 to 895)
  AUTHORS   Janssens,B., Goossens,S., Staes,K., Gilbert,B., van Hengel,J.,
            Colpaert,C., Bruyneel,E., Mareel,M. and van Roy,F.
  TITLE     alphaT-catenin: a novel tissue-specific beta-catenin-binding
            protein mediating strong cell-cell adhesion
  JOURNAL   J Cell Sci 114 (Pt 17), 3177-3188 (2001)
   PUBMED   11590244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142745.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142745.1, AF344871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..895
                     /product="catenin alpha-3 isoform 1"
                     /note="alpha-catenin-like protein; alpha T-catenin;
                     catenin (cadherin associated protein), alpha 3;
                     cadherin-associated protein; alphaT-catenin"
                     /calculated_mol_wt=99672
     Region          18..856
                     /region_name="Vinculin"
                     /note="Vinculin family; pfam01044"
                     /db_xref="CDD:460040"
     Site            160
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            361
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Region          635..660
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            647
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q65CL1.2)"
     CDS             1..895
                     /gene="Ctnna3"
                     /gene_synonym="4930429L08Rik; 4933408A16; Catna3; Vr22"
                     /coded_by="NM_001164376.1:160..2847"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23901.1"
                     /db_xref="GeneID:216033"
                     /db_xref="MGI:MGI:2661445"
ORIGIN      
        1 msaetpitln mdtqdlqiqt ftvekllepl iiqvttlvnc pqnpsnrkkg rskrarvlla
       61 sveeatwnll dkgemiakea tvlkeelaaa lqevrkeska lkvsaerftd dpcylpkrea
      121 vvqaaralla avtrllvlad midvmcllqh vssfqrtfes lknvsnksdl qrtyqklgke
      181 lesldylafk rqqdlkspsq rdeiagarat lkenspllhs icsaclehsd vaslkaskdt
      241 vceeiqnald visnasqgiq napappepqa atlgsafdel enlivlnplt vteedvrpsl
      301 ekrleaiisg aalladssct rdlhreriia ecnairqalq dllteymsnt gktersntln
      361 taivnmskkt rdlrrqlrka iidhisdsfl dttvpllvli eaakngrvke ikdyaaifhe
      421 htgrlvevan lacsmstned gikivriaan hletlcpqii naalalasrp ksqvvkntme
      481 mykrtwehyi hvlteavddi tsiddflavs eshiledvnk ciialrdqda dnldraagai
      541 rgraarvahi vagemdsyep gaytegvmrn vnfltstvip efvtqvnval dalsknslta
      601 lddnqfvdis kkiydtihdi rcsvmmirtp eeledvsdle ddhevrshts iqtegktdra
      661 kmtqlpeaek ekiaeqvadf kkvkskldae ieiwddtsnd iivlakkmcm immemtdftr
      721 gkgplkhttd viyaakmise sgsrmdvlar qianqcpdpp ckqdllayle qikfyshqlk
      781 icsqvkaeiq nlggelivsa ldsvtsliqa aknlmnavvq tvkmsyiast kiiriqssag
      841 prhpvvmwrm kapakkplik rekpeetwaa vrrgsakkki hpvqvmsefr grqvy
//
LOCUS       NP_033531                368 aa            linear   ROD 27-AUG-2025
DEFINITION  vascular endothelial growth factor A, long form isoform 2 [Mus
            musculus].
ACCESSION   NP_033531
VERSION     NP_033531.3
DBSOURCE    REFSEQ: accession NM_009505.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 368)
  AUTHORS   Man,X., Usui,N., Doi,M. and Shimada,S.
  TITLE     Sex differences in placental structure and gene expression in ICR
            mice during embryonic development
  JOURNAL   Sci Rep 15 (1), 24067 (2025)
   PUBMED   40617958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 368)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   3  (residues 1 to 368)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 368)
  AUTHORS   Eswarappa,S.M., Potdar,A.A., Koch,W.J., Fan,Y., Vasu,K.,
            Lindner,D., Willard,B., Graham,L.M., DiCorleto,P.E. and Fox,P.L.
  TITLE     Programmed translational readthrough generates antiangiogenic
            VEGF-Ax
  JOURNAL   Cell 157 (7), 1605-1618 (2014)
   PUBMED   24949972
REFERENCE   5  (residues 1 to 368)
  AUTHORS   Bastide,A., Karaa,Z., Bornes,S., Hieblot,C., Lacazette,E., Prats,H.
            and Touriol,C.
  TITLE     An upstream open reading frame within an IRES controls expression
            of a specific VEGF-A isoform
  JOURNAL   Nucleic Acids Res 36 (7), 2434-2445 (2008)
   PUBMED   18304943
REFERENCE   6  (residues 1 to 368)
  AUTHORS   Huez,I., Bornes,S., Bresson,D., Creancier,L. and Prats,H.
  TITLE     New vascular endothelial growth factor isoform generated by
            internal ribosome entry site-driven CUG translation initiation
  JOURNAL   Mol Endocrinol 15 (12), 2197-2210 (2001)
   PUBMED   11731620
REFERENCE   7  (residues 1 to 368)
  AUTHORS   Tee,M.K. and Jaffe,R.B.
  TITLE     A precursor form of vascular endothelial growth factor arises by
            initiation from an upstream in-frame CUG codon
  JOURNAL   Biochem J 359 (Pt 1), 219-226 (2001)
   PUBMED   11563986
REFERENCE   8  (residues 1 to 368)
  AUTHORS   Meiron,M., Anunu,R., Scheinman,E.J., Hashmueli,S. and Levi,B.Z.
  TITLE     New isoforms of VEGF are translated from alternative initiation CUG
            codons located in its 5'UTR
  JOURNAL   Biochem Biophys Res Commun 282 (4), 1053-1060 (2001)
   PUBMED   11352659
REFERENCE   9  (residues 1 to 368)
  AUTHORS   Claffey,K.P., Wilkison,W.O. and Spiegelman,B.M.
  TITLE     Vascular endothelial growth factor. Regulation by cell
            differentiation and activated second messenger pathways
  JOURNAL   J Biol Chem 267 (23), 16317-16322 (1992)
   PUBMED   1644816
REFERENCE   10 (residues 1 to 368)
  AUTHORS   Breier,G., Albrecht,U., Sterrer,S. and Risau,W.
  TITLE     Expression of vascular endothelial growth factor during embryonic
            angiogenesis and endothelial cell differentiation
  JOURNAL   Development 114 (2), 521-532 (1992)
   PUBMED   1592003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY001490.1, CK626177.1,
            BC061468.1 and AK031905.1.
            
            On Nov 16, 2007 this sequence version replaced NP_033531.2.
            
            Summary: This gene is a member of the PDGF/VEGF growth factor
            family. It encodes a heparin-binding protein, which exists as a
            disulfide-linked homodimer. This growth factor induces
            proliferation and migration of vascular endothelial cells, and is
            essential for both physiological and pathological angiogenesis.
            Disruption of this gene in mice resulted in abnormal embryonic
            blood vessel formation. This gene is upregulated in many known
            tumors and its expression is correlated with tumor stage and
            progression. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. There is also
            evidence for alternative translation initiation from upstream
            non-AUG (CUG) codons resulting in additional isoforms. A recent
            study showed that a C-terminally extended isoform is produced by
            use of an alternative in-frame translation termination codon via a
            stop codon readthrough mechanism, and that this isoform is
            antiangiogenic. Expression of some isoforms derived from the AUG
            start codon is regulated by a small upstream open reading frame,
            which is located within an internal ribosome entry site.[provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2) lacks an in-frame, internal
            coding exon, compared to variant 1. This variant can initiate
            translation from a non-AUG (CUG) site and also from a downstream,
            in-frame AUG site. The isoform (2) represented in this RefSeq is
            translated from the CUG start codon and it lacks an internal
            segment, compared to isoform 1.
            
            Sequence Note: A non-AUG (CUG) translation initiation codon is
            selected for this RefSeq based on conservation with the human
            ortholog, for which the use of the CUG start codon has been
            demonstrated in the literature, including PMIDs:11352659, 11563986
            and 11731620.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061468.1, SRR1660821.338789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 11352659, 11563986
            RefSeq Select criteria   :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.79 cM"
     Protein         1..368
                     /product="vascular endothelial growth factor A, long form
                     isoform 2"
                     /note="vascular permeability factor; vascular endothelial
                     growth factor A, long form"
                     /calculated_mol_wt=40157
     Region          58
                     /region_name="alternative non-AUG (CUG) translation
                     initiation site"
     Region          179
                     /region_name="alternative AUG translation initiation site"
     Region          227..309
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; smart00141"
                     /db_xref="CDD:197537"
     Site            order(227..230,264,266..269,284..287)
                     /site_type="active"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     Site            order(229,260,264,271,305,307)
                     /site_type="other"
                     /note="cysteine knot motif"
                     /db_xref="CDD:238079"
     Site            order(254,263)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238079"
     Region          320..368
                     /region_name="VEGF_C"
                     /note="VEGF heparin-binding domain; pfam14554"
                     /db_xref="CDD:405273"
     CDS             1..368
                     /gene="Vegfa"
                     /gene_synonym="L-VEGF; Vegf; Vpf"
                     /coded_by="NM_009505.4:488..1594"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (CUG) translation initiation codon"
                     /db_xref="CCDS:CCDS28818.2"
                     /db_xref="GeneID:22339"
                     /db_xref="MGI:MGI:103178"
ORIGIN      
        1 mtdrqtdtap spsahllagg lptvdaaasr eepkpapggg vegvgargia rklfvqllgs
       61 srsvvavvca agdkpigagr sassglekpg pekrgeeeke eergpqwalg sqepsswtge
      121 aavcadsapa arapqapara svpegrgarq gaqesglprs psrrgsasra gpgrasetmn
      181 fllswvhwtl alllylhhak wsqaaptteg eqkshevikf mdvyqrsycr pietlvdifq
      241 eypdeieyif kpscvplmrc agccndeale cvptsesnit mqimrikphq sqhigemsfl
      301 qhsrcecrpk kdrtkpenhc epcserrkhl fvqdpqtckc sckntdsrck arqlelnert
      361 crcdkprr
//
LOCUS       NP_001408092             379 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform q [Mus musculus].
ACCESSION   NP_001408092 XP_030109109
VERSION     NP_001408092.1
DBSOURCE    REFSEQ: accession NM_001421163.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 379)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 379)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 379)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 379)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109109.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.1735165.1,
                                           SRR14995045.480703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..379
                     /product="ELAV-like protein 4 isoform q"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=41674
     Region          56..378
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..379
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421163.1:257..1396"
                     /note="isoform q is encoded by transcript variant 20"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mfeisrtlna allnneiist mepqvsngpt sntsngpssn nrncpspmqt gaatddsktn
       61 livnylpqnm tqeefrslfg sigeiesckl vrdkitgqsl gygfvnyidp kdaekaintl
      121 nglrlqtkti kvsyarpssa sirdanlyvs glpktmtqke leqlfsqygr iitsrilvdq
      181 vtgvsrgvgf irfdkrieae eaikglngqk psgatepitv kfannpsqks sqallsqlyq
      241 spnrrypgpl hhqaqrfrld nllnmaygvk rfspitidgm tslvgmnipg htgtgwcifv
      301 ynlspdsdes vlwqlfgpfg avnnvkvird fntnkckgfg fvtmtnydea amaiaslngy
      361 rlgdrvlqvs fktnkahks
//
LOCUS       NP_034189                340 aa            linear   ROD 27-AUG-2025
DEFINITION  meiotic recombination protein DMC1/LIM15 homolog isoform 1 [Mus
            musculus].
ACCESSION   NP_034189
VERSION     NP_034189.1
DBSOURCE    REFSEQ: accession NM_010059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 340)
  AUTHORS   Zhao,B.W., Zhang,Y.N., Meng,T.G., Xu,Y.H., Lu,Y.K., Sun,S.M.,
            Guo,J.N., Yang,X.M. and Wang,Z.B.
  TITLE     Re-establishment of H3K9me2 eliminates the transcriptional
            inhibition of ST18 on meiotic genes and orchestrates female germ
            cell development
  JOURNAL   Nucleic Acids Res 53 (13) (2025)
   PUBMED   40650982
REFERENCE   2  (residues 1 to 340)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   3  (residues 1 to 340)
  AUTHORS   Yoshimura,S., Shimada,R., Kikuchi,K., Kawagoe,S., Abe,H.,
            Iisaka,S., Fujimura,S., Yasunaga,K.I., Usuki,S., Tani,N., Ohba,T.,
            Kondoh,E., Saio,T., Araki,K. and Ishiguro,K.I.
  TITLE     Atypical heat shock transcription factor HSF5 is critical for male
            meiotic prophase under non-stress conditions
  JOURNAL   Nat Commun 15 (1), 3330 (2024)
   PUBMED   38684656
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 340)
  AUTHORS   Yoshida,K., Kondoh,G., Matsuda,Y., Habu,T., Nishimune,Y. and
            Morita,T.
  TITLE     The mouse RecA-like gene Dmc1 is required for homologous chromosome
            synapsis during meiosis
  JOURNAL   Mol Cell 1 (5), 707-718 (1998)
   PUBMED   9660954
REFERENCE   5  (residues 1 to 340)
  AUTHORS   Pittman,D.L., Cobb,J., Schimenti,K.J., Wilson,L.A., Cooper,D.M.,
            Brignull,E., Handel,M.A. and Schimenti,J.C.
  TITLE     Meiotic prophase arrest with failure of chromosome synapsis in mice
            deficient for Dmc1, a germline-specific RecA homolog
  JOURNAL   Mol Cell 1 (5), 697-705 (1998)
   PUBMED   9660953
REFERENCE   6  (residues 1 to 340)
  AUTHORS   Koike,M., Matsuda,Y., Mimori,T., Harada,Y.N., Shiomi,N. and
            Shiomi,T.
  TITLE     Chromosomal localization of the mouse and rat DNA double-strand
            break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA
            expression in various mouse tissues
  JOURNAL   Genomics 38 (1), 38-44 (1996)
   PUBMED   8954777
REFERENCE   7  (residues 1 to 340)
  AUTHORS   Matsuda,Y., Habu,T., Hori,T. and Morita,T.
  TITLE     Chromosome mapping of the mouse homologue of DMC1, the yeast
            meiosis-specific homologous recombination gene
  JOURNAL   Chromosome Res 4 (3), 249-250 (1996)
   PUBMED   8793211
REFERENCE   8  (residues 1 to 340)
  AUTHORS   Habu,T., Taki,T., West,A., Nishimune,Y. and Morita,T.
  TITLE     The mouse and human homologs of DMC1, the yeast meiosis-specific
            homologous recombination gene, have a common unique form of
            exon-skipped transcript in meiosis
  JOURNAL   Nucleic Acids Res 24 (3), 470-477 (1996)
   PUBMED   8602360
REFERENCE   9  (residues 1 to 340)
  AUTHORS   Sato,S., Seki,N., Hotta,Y. and Tabata,S.
  TITLE     Expression profiles of a human gene identified as a structural
            homologue of meiosis-specific recA-like genes
  JOURNAL   DNA Res 2 (4), 183-186 (1995)
   PUBMED   8590282
REFERENCE   10 (residues 1 to 340)
  AUTHORS   Sato,S., Kobayashi,T., Hotta,Y. and Tabata,S.
  TITLE     Characterization of a mouse recA-like gene specifically expressed
            in testis
  JOURNAL   DNA Res 2 (3), 147-150 (1995)
   PUBMED   8581742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK169570.1, BC116767.1 and
            AV451479.1.
            
            Summary: This gene encodes a member of the superfamily of
            recombinases (also called DNA strand-exchange proteins).
            Recombinases are important for repairing double-strand DNA breaks
            during mitosis and meiosis. This protein, which is evolutionarily
            conserved, is reported to be essential for meiotic homologous
            recombination and may thus play an important role in generating
            diversity of genetic information. In mouse, deficiency of this gene
            causes infertility. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64107.1, BC116767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.79 cM"
     Protein         1..340
                     /product="meiotic recombination protein DMC1/LIM15 homolog
                     isoform 1"
                     /note="meiotic recombination protein DMC1/LIM15 homolog;
                     disrupted meiotic cDNA 1 homolog; DMC1 dosage suppressor
                     of mck1 homolog, meiosis-specific homologous
                     recombination"
                     /calculated_mol_wt=37690
     Region          24..338
                     /region_name="recomb_DMC1"
                     /note="meiotic recombinase Dmc1; TIGR02238"
                     /db_xref="CDD:131292"
     CDS             1..340
                     /gene="Dmc1"
                     /gene_synonym="Dmc1h; Lim15; Mei11; sgdp"
                     /coded_by="NM_010059.3:182..1204"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS27644.1"
                     /db_xref="GeneID:13404"
                     /db_xref="MGI:MGI:105393"
ORIGIN      
        1 mkedqvvqee sgfqddeesl fqdidllqkh ginmadikkl ksvgictikg iqmttrralc
       61 nvkglseakv ekikeaankl iepgfltafq yserrkmvfh ittgsqefdk llgggiesma
      121 iteafgefrt gktqlshtlc vtaqlpgtgg ysggkiifid tentfrpdrl rdiadrfnvd
      181 heavldnvly araytsehqm elldyvaakf heeagifkll iidsimalfr vdfsgrgela
      241 erqqklaqml srlqkiseey nvavfvtnqm tadpgatmtf qadpkkpigg hilahasttr
      301 islrkgrgel riakiydspe mpeneatfai taggigdake
//
LOCUS       NP_032809                347 aa            linear   ROD 27-AUG-2025
DEFINITION  pre-B-cell leukemia transcription factor 1 isoform b [Mus
            musculus].
ACCESSION   NP_032809
VERSION     NP_032809.1
DBSOURCE    REFSEQ: accession NM_008783.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 347)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 347)
  AUTHORS   Menezes,N.A., Peterson,K.J., Guo,X., Castiglioni,V., Kalvisa,A.,
            Filimonow,K., Schachter,K., Schuh,C.M., Pasias,A., Mariani,L.,
            Brickman,J.M., Sedzinski,J. and Ferretti,E.
  TITLE     Cell-context response to germ layer differentiation signals is
            predetermined by the epigenome in regionalized epiblast populations
  JOURNAL   Nat Commun 16 (1), 5000 (2025)
   PUBMED   40442089
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 347)
  AUTHORS   Wu,M.L., Wheeler,K., Silasi,R., Lupu,F. and Griffin,C.T.
  TITLE     Endothelial Chromatin-Remodeling Enzymes Regulate the Production of
            Critical ECM Components During Murine Lung Development
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (8), 1784-1798 (2024)
   PUBMED   38868942
REFERENCE   4  (residues 1 to 347)
  AUTHORS   Wang,F.C., Zhang,X.N., Wu,S.X., He,Z., Zhang,L.Y. and Yang,Q.E.
  TITLE     Loss of PBX1 function in Leydig cells causes testicular dysgenesis
            and male sterility
  JOURNAL   Cell Mol Life Sci 81 (1), 212 (2024)
   PUBMED   38724675
  REMARK    GeneRIF: Loss of PBX1 function in Leydig cells causes testicular
            dysgenesis and male sterility.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 347)
  AUTHORS   Cuda,C.M., Li,S., Liang,S., Yin,Y., Potula,H.H., Xu,Z.,
            Sengupta,M., Chen,Y., Butfiloski,E., Baker,H., Chang,L.J.,
            Dozmorov,I., Sobel,E.S. and Morel,L.
  TITLE     Pre-B cell leukemia homeobox 1 is associated with lupus
            susceptibility in mice and humans
  JOURNAL   J Immunol 188 (2), 604-614 (2012)
   PUBMED   22180614
  REMARK    GeneRIF: Pbx1 is a novel lupus susceptibility gene that regulates T
            cell activation and tolerance.
REFERENCE   6  (residues 1 to 347)
  AUTHORS   Knoepfler,P.S. and Kamps,M.P.
  TITLE     The pentapeptide motif of Hox proteins is required for cooperative
            DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA
            binding by Pbx1
  JOURNAL   Mol Cell Biol 15 (10), 5811-5819 (1995)
   PUBMED   7565734
REFERENCE   7  (residues 1 to 347)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
REFERENCE   8  (residues 1 to 347)
  AUTHORS   Kagawa,N., Ogo,A., Takahashi,Y., Iwamatsu,A. and Waterman,M.R.
  TITLE     A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for
            the homeodomain protein Pbx1
  JOURNAL   J Biol Chem 269 (29), 18716-18719 (1994)
   PUBMED   7913464
REFERENCE   9  (residues 1 to 347)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   10 (residues 1 to 347)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK144346.1 and BC054376.1.
            
            Summary: This gene encodes a homeobox protein that belongs to the
            three-amino-acid loop extension/Pre-B cell leukemia transcription
            factor (TALE/PBX) family of proteins. The encoded protein is
            involved in several biological processes during embryogenesis
            including steroidogenesis, sexual development and the maintenance
            of hematopoietic stem cells. This protein functions in the
            development of several organ systems and plays a role in skeletal
            patterning and programming. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (b) has a different 3' structure
            and lacks an alternate exon in the 3' coding region resulting in a
            frameshift compared to variant a. The encoded isoform (b) has a
            distinct C-terminus and is shorter than isoform a. Variants b and c
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054376.1, SRR7345562.5061828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 75.95 cM"
     Protein         1..347
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform b"
                     /note="pre-B-cell leukemia transcription factor 1;
                     homeobox protein PBX1"
                     /calculated_mol_wt=38296
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          42..232
                     /region_name="PBC"
                     /note="PBC domain; pfam03792"
                     /db_xref="CDD:461052"
     Region          45..124
                     /region_name="PBC-A.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          127..232
                     /region_name="PBC-B.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
                     /note="propagated from UniProtKB/Swiss-Prot (P41778.2)"
     Region          234..294
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(234..238,240,260,266,279,281..282,285..286,288..290,
                     292..293)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(236,239,282,285..286,289)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            286
                     /site_type="other"
                     /note="Required for binding to the NFIL3 promoter.
                     /evidence=ECO:0000269|PubMed:32190943; propagated from
                     UniProtKB/Swiss-Prot (P41778.2)"
     CDS             1..347
                     /gene="Pbx1"
                     /gene_synonym="2310056B04Rik; D230003C07Rik; Pbx-1"
                     /coded_by="NM_008783.3:666..1709"
                     /note="isoform b is encoded by transcript variant b"
                     /db_xref="CCDS:CCDS15462.1"
                     /db_xref="GeneID:18514"
                     /db_xref="MGI:MGI:97495"
ORIGIN      
        1 mdeqprlmhs hagvgmaghp glsqhlqdga ggtegeggrk qdigdilqqi mtitdqslde
       61 aqarkhalnc hrmkpalfnv lceikektvl sirgaqeeep tdpqlmrldn mllaegvagp
      121 ekgggsaaaa aaaaasggag sdnsvehsdy raklsqirqi yhtelekyeq acneftthvm
      181 nllreqsrtr pispkeierm vsiihrkfss iqmqlkqstc eavmilrsrf ldarrkrrnf
      241 nkqateilne yfyshlsnpy pseeakeela kkcgitvsqv snwfgnkrir ykknigkfqe
      301 eaniyaakta vtatnvsahg sqanspstpn saggypspcy qpdrriq
//
LOCUS       NP_001415303             206 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 5 [Mus musculus].
ACCESSION   NP_001415303
VERSION     NP_001415303.1
DBSOURCE    REFSEQ: accession NM_001428374.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 206)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1620998.1,
                                           SRR17253011.8890041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..206
                     /product="autophagy protein 5 isoform 5"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=24115
     Region          35..201
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..206
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001428374.1:244..864"
                     /note="isoform 5 is encoded by transcript variant 6"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mtddkdvlrd vwfgriptcf tlyqdeiter eaepyysfpe kdllhcpskd aveahfmscm
       61 keadalkhks qvinemqkkd hkqlwmglqn drfdqfwain rklmeyppee ngfryipfri
      121 yqttterpfi qklfrpvaad gqlhtlgdll revcpsavap edgekrsqvm ihgiepmlet
      181 plqwlsehls ypdnflhisi vpqptd
//
LOCUS       NP_001416282             119 aa            linear   ROD 27-AUG-2025
DEFINITION  DNA-binding protein inhibitor ID-3 [Mus musculus].
ACCESSION   NP_001416282
VERSION     NP_001416282.1
DBSOURCE    REFSEQ: accession NM_001429353.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 119)
  AUTHORS   Zhou,J., Vitali,I., Roig-Puiggros,S., Javed,A., Cantando,I.,
            Puglisi,M., Bezzi,P., Jabaudon,D., Mayer,C. and Bocchi,R.
  TITLE     Dual lineage origins contribute to neocortical astrocyte diversity
  JOURNAL   Nat Commun 16 (1), 6992 (2025)
   PUBMED   40738880
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 119)
  AUTHORS   Fujieda,K., Sumihiro,H., Saito,R., Kobayashi,K., Miyanohara,Y.,
            Abe,S., Tsujii,T., Tu,H.Y. and Furukawa,T.
  TITLE     Id2 transcriptional repressor promotes retinal Muller glial cell
            fate choice by increasing Notch activity
  JOURNAL   Biochem Biophys Res Commun 771, 151966 (2025)
   PUBMED   40398096
REFERENCE   3  (residues 1 to 119)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 119)
  AUTHORS   Brinkmeier,M.L., Wang,S.Q., Pittman,H.A., Cheung,L.Y. and Prasov,L.
  TITLE     Myelin regulatory factor (MYRF) is a critical early regulator of
            retinal pigment epithelial development
  JOURNAL   PLoS Genet 21 (4), e1011670 (2025)
   PUBMED   40233131
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 119)
  AUTHORS   Gago da Graca,C., Sheikh,A.A., Newman,D.M., Wen,L., Li,S., Shen,J.,
            Zhang,Y., Gabriel,S.S., Chisanga,D., Seow,J., Poch,A., Rausch,L.,
            Nguyen,M.T., Singh,J., Su,C.H., Cluse,L.A., Tsui,C., Burn,T.N.,
            Park,S.L., Von Scheidt,B., Mackay,L.K., Vasanthakumar,A.,
            Bending,D., Shi,W., Cui,W., Schroder,J., Johnstone,R.W., Kallies,A.
            and Utzschneider,D.T.
  TITLE     Stem-like memory and precursors of exhausted T cells share a common
            progenitor defined by ID3 expression
  JOURNAL   Sci Immunol 10 (103), eadn1945 (2025)
   PUBMED   39888981
REFERENCE   6  (residues 1 to 119)
  AUTHORS   Riechmann,V. and Sablitzky,F.
  TITLE     Mutually exclusive expression of two dominant-negative
            helix-loop-helix (dnHLH) genes, Id4 and Id3, in the developing
            brain of the mouse suggests distinct regulatory roles of these
            dnHLH proteins during cellular proliferation and differentiation of
            the nervous system
  JOURNAL   Cell Growth Differ 6 (7), 837-843 (1995)
   PUBMED   7547505
REFERENCE   7  (residues 1 to 119)
  AUTHORS   Ellmeier,W. and Weith,A.
  TITLE     Expression of the helix-loop-helix gene Id3 during murine embryonic
            development
  JOURNAL   Dev Dyn 203 (2), 163-173 (1995)
   PUBMED   7655079
REFERENCE   8  (residues 1 to 119)
  AUTHORS   Menezes,J.R. and Luskin,M.B.
  TITLE     Expression of neuron-specific tubulin defines a novel population in
            the proliferative layers of the developing telencephalon
  JOURNAL   J Neurosci 14 (9), 5399-5416 (1994)
   PUBMED   8083744
REFERENCE   9  (residues 1 to 119)
  AUTHORS   Ellmeier,W., Aguzzi,A., Kleiner,E., Kurzbauer,R. and Weith,A.
  TITLE     Mutually exclusive expression of a helix-loop-helix gene and N-myc
            in human neuroblastomas and in normal development
  JOURNAL   EMBO J 11 (7), 2563-2571 (1992)
   PUBMED   1628620
REFERENCE   10 (residues 1 to 119)
  AUTHORS   Christy,B.A., Sanders,L.K., Lau,L.F., Copeland,N.G., Jenkins,N.A.
            and Nathans,D.
  TITLE     An Id-related helix-loop-helix protein encoded by a growth
            factor-inducible gene
  JOURNAL   Proc Natl Acad Sci U S A 88 (5), 1815-1819 (1991)
   PUBMED   2000388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935264.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1176147.1,
                                           SRR17784644.363182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..119
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     Protein         1..119
                     /product="DNA-binding protein inhibitor ID-3"
                     /note="ID-like protein inhibitor HLH 462; inhibitor of
                     differentiation 3"
                     /calculated_mol_wt=12958
     Region          23..83
                     /region_name="bHLH_dnHLH_ID3"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     DNA-binding protein inhibitor ID3 and similar proteins;
                     cd19693"
                     /db_xref="CDD:381536"
     Site            order(23..36,38..39,43..44,47..56,58..67,70..71,73..74,
                     76..78,80..81)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381536"
     Region          35..87
                     /region_name="Interaction with IFI204.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P41133.1)"
     CDS             1..119
                     /gene="Id3"
                     /gene_synonym="bHLHb25; Hlh462; Idb3"
                     /coded_by="NM_001429353.1:56..415"
                     /db_xref="GeneID:15903"
                     /db_xref="MGI:MGI:96398"
ORIGIN      
        1 mkalspvrgc yeavcclser slaiargrgk spsteeplsl lddmnhcysr lrelvpgvpr
       61 gtqlsqveil qrvidyildl qvvlaepapg ppdgphlpiq taeltpelvi skdkrsfch
//
LOCUS       NP_001334504             442 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 5 [Mus musculus].
ACCESSION   NP_001334504 XP_017170897
VERSION     NP_001334504.1
DBSOURCE    REFSEQ: accession NM_001347575.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            On Dec 1, 2016 this sequence version replaced XP_017170897.1.
            
            Transcript Variant: This variant (12) differs in the 5' UTR and
            uses an alternate in-frame splice site in the 3' coding region,
            compared to variant 3, resulting in an isoform (5) that is shorter
            than isoform 3. Variants 8 through 14 all encode isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.52745.1,
                                           SRR9219379.48162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..442
                     /product="myocyte-specific enhancer factor 2C isoform 5"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=47825
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..442
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347575.2:401..1729"
                     /note="isoform 5 is encoded by transcript variant 12"
                     /db_xref="CCDS:CCDS84043.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv sedvdlllnq rinnsqsaqs latpvvsvat
      301 ptlpgqgmgg ypsaisttyg teyslssadl sslsgfntas alhlgsvtgw qqqhlhnmpp
      361 salsqlgdrt ttpsrypqht trheagrspv dslsscsssy dgsdredhrn efhspigltr
      421 pspderesps vkrmrlsegw at
//
LOCUS       NP_033072                558 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor RelB isoform 1 [Mus musculus].
ACCESSION   NP_033072
VERSION     NP_033072.2
DBSOURCE    REFSEQ: accession NM_009046.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 558)
  AUTHORS   Geiselhoringer,A.L., Kolland,D., Patt,A.J., Hammann,L., Kohler,A.,
            Kreft,L., Wichmann,N., Hils,M., Ruedl,C., Riemann,M.,
            Biedermann,T., Anz,D., Diefenbach,A., Voehringer,D.,
            Schmidt-Weber,C.B., Straub,T., Pasztoi,M. and Ohnmacht,C.
  TITLE     Dominant immune tolerance in the intestinal tract imposed by
            RelB-dependent migratory dendritic cells regulates protective type
            2 immunity
  JOURNAL   Nat Commun 15 (1), 9143 (2024)
   PUBMED   39443450
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 558)
  AUTHORS   Deka,A., Kumar,N., Basu,S., Chawla,M., Bhattacharya,N., Ali,S.A.,
            Bhawna, Madan,U., Kumar,S., Das,B., Sengupta,D., Awasthi,A. and
            Basak,S.
  TITLE     Non-canonical NF-kappaB signaling limits the tolerogenic
            beta-catenin-Raldh2 axis in gut dendritic cells to exacerbate
            intestinal pathologies
  JOURNAL   EMBO J 43 (18), 3895-3915 (2024)
   PUBMED   39060515
REFERENCE   3  (residues 1 to 558)
  AUTHORS   Lin,Y., Liu,M., Deng,P. and Zhang,J.
  TITLE     TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization
  JOURNAL   Cell Signal 120, 111210 (2024)
   PUBMED   38705503
  REMARK    GeneRIF: TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization.
            Erratum:[Cell Signal. 2024 Dec;124:111367. doi:
            10.1016/j.cellsig.2024.111367. PMID: 39214841]
REFERENCE   4  (residues 1 to 558)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   5  (residues 1 to 558)
  AUTHORS   Zheng,C., Liu,L., Liu,C., Chu,F., Lang,Y., Liu,S., Mi,Y., Zhu,J.
            and Jin,T.
  TITLE     Alleviation of experimental autoimmune encephalomyelitis by
            transferring low RelB expression tolerogenic dendritic cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166934 (2024)
   PUBMED   37931715
  REMARK    GeneRIF: Alleviation of experimental autoimmune encephalomyelitis
            by transferring low RelB expression tolerogenic dendritic cells.
REFERENCE   6  (residues 1 to 558)
  AUTHORS   Burkly,L., Hession,C., Ogata,L., Reilly,C., Marconi,L.A., Olson,D.,
            Tizard,R., Cate,R. and Lo,D.
  TITLE     Expression of relB is required for the development of thymic
            medulla and dendritic cells
  JOURNAL   Nature 373 (6514), 531-536 (1995)
   PUBMED   7845467
REFERENCE   7  (residues 1 to 558)
  AUTHORS   Weih,F., Carrasco,D., Durham,S.K., Barton,D.S., Rizzo,C.A.,
            Ryseck,R.P., Lira,S.A. and Bravo,R.
  TITLE     Multiorgan inflammation and hematopoietic abnormalities in mice
            with a targeted disruption of RelB, a member of the NF-kappa B/Rel
            family
  JOURNAL   Cell 80 (2), 331-340 (1995)
   PUBMED   7834753
REFERENCE   8  (residues 1 to 558)
  AUTHORS   Egwuagu,C.E., Sztein,J., Chan,C.C., Mahdi,R., Nussenblatt,R.B. and
            Chepelinsky,A.B.
  TITLE     gamma Interferon expression disrupts lens and retinal
            differentiation in transgenic mice
  JOURNAL   Dev Biol 166 (2), 557-568 (1994)
   PUBMED   7813776
REFERENCE   9  (residues 1 to 558)
  AUTHORS   Lo,D., Quill,H., Burkly,L., Scott,B., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     A recessive defect in lymphocyte or granulocyte function caused by
            an integrated transgene
  JOURNAL   Am J Pathol 141 (5), 1237-1246 (1992)
   PUBMED   1443055
REFERENCE   10 (residues 1 to 558)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            On Jun 19, 2003 this sequence version replaced NP_033072.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019765.1, M83380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.93 cM"
     Protein         1..558
                     /product="transcription factor RelB isoform 1"
                     /note="transcription factor relB"
                     /calculated_mol_wt=60174
     Region          1..76
                     /region_name="RelB_leu_zip"
                     /note="RelB leucine zipper; pfam16180"
                     /db_xref="CDD:374415"
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04863.2)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01201; propagated from
                     UniProtKB/Swiss-Prot (Q04863.2)"
     Region          22..50
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04863.2)"
     Site            84
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:11781828; propagated from
                     UniProtKB/Swiss-Prot (Q04863.2)"
     Region          103..274
                     /region_name="RHD-n_RelB"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of the reticuloendotheliosis viral oncogene homolog
                     B (RelB) protein; cd07886"
                     /db_xref="CDD:143646"
     Site            order(117,119..120,122..123,125,127,129,209..211)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143646"
     Region          282..378
                     /region_name="RHD_dimer"
                     /note="Rel homology dimerization domain; pfam16179"
                     /db_xref="CDD:465045"
     Region          381..558
                     /region_name="RelB_transactiv"
                     /note="RelB transactivation domain; pfam16181"
                     /db_xref="CDD:406565"
     Region          387..391
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04863.2)"
     Region          411..416
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04863.2)"
     Site            552
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:11781828; propagated from
                     UniProtKB/Swiss-Prot (Q04863.2)"
     CDS             1..558
                     /gene="Relb"
                     /gene_synonym="shep"
                     /coded_by="NM_009046.3:186..1862"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39799.1"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
ORIGIN      
        1 mpsrraares apelgalgss dlsslsltvs rttdeleiid eyikengfgl dgtqlsempr
       61 lvprgpasls svtlgpaapp ppatpswsct lgrlvspgpc prpylviteq pkqrgmrfry
      121 ecegrsagsi lgessteask tlpaielrdc gglrevevta clvwkdwphr vhphslvgkd
      181 ctdgvcrvrl rphvsprhsf nnlgiqcvrk keieaaierk iqlgidpyna gslknhqevd
      241 mnvvricfqa syrdqqghlh rmdpilsepv ydkkstntse lricrinkes gpctggeely
      301 llcdkvqked isvvfstasw egradfsqad vhrqiaivfk tppyedleis epvtvnvflq
      361 rltdgvcsep lpftylprdh dsygvdkkrk rglpdvlgel sssdphgies krrkkkpvfl
      421 dhflpghssg lflppsalqp adsdffpasi slpgleppgg pdllddgfay dpsaptlftm
      481 ldllppappl asavvgsgga gatvvessgp eplsldsfaa pgpgdvgtas lvgsnmfpnq
      541 yreaafgggl lspgpeat
//
LOCUS       NP_001334495             474 aa            linear   ROD 27-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2C isoform 3 [Mus musculus].
ACCESSION   NP_001334495 XP_006517184
VERSION     NP_001334495.1
DBSOURCE    REFSEQ: accession NM_001347566.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Hu,X., Wu,J., Shi,L., Wang,F., He,K., Tan,P., Hu,Y., Yang,Y.,
            Wang,D., Ma,T. and Ding,S.
  TITLE     The transcription factor MEF2C restrains microglial overactivation
            by inhibiting kinase CDK2
  JOURNAL   Immunity 58 (4), 946-960 (2025)
   PUBMED   40139186
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Pun,R., Thapa,A., Takafuji,S.R., Suzuki,R.M., Kay,G.F.,
            Howard,T.D., Kim,M.H. and North,B.J.
  TITLE     BubR1 Controls Heart Development by Promoting Expression of
            Cardiogenesis Regulators
  JOURNAL   J Am Heart Assoc 14 (6), e038286 (2025)
   PUBMED   40055864
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025631.2 and CU074400.3.
            
            On Dec 1, 2016 this sequence version replaced XP_006517184.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 3. Variants 3, 4 and 5 all encode isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.52396.1,
                                           SRR9219382.152796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     Protein         1..474
                     /product="myocyte-specific enhancer factor 2C isoform 3"
                     /note="myocyte-specific enhancer factor 2C"
                     /calculated_mol_wt=51147
     Region          1..245
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            4
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:18086704; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:8663403; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          91..118
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            98
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            116
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            119
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            222
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            228
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            234
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            239
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            240
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            252
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            264
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          271..278
                     /region_name="Beta domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            293
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK14.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          368..399
                     /region_name="Transcription repressor.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Region          375..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            396
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            420
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK7.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            433..434
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     Site            446
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q06413; propagated from
                     UniProtKB/Swiss-Prot (Q8CFN5.2)"
     CDS             1..474
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /coded_by="NM_001347566.2:401..1825"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS84042.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns tnklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcdspd pdaddsvghs pesedkyrki
      121 nedidlmisr qrlcavppps fempvtipvs shnslvysnp vstlgnpnll plahpslqrn
      181 smspgvthrp psagntgglm ggdltsgagt sagngygnpr nspgllvspg nlnkniqaks
      241 pppmnlgmnn rkpdlrvlip pgskntmpsv sedvdlllnq rinnsqsaqs latpvvsvat
      301 ptlpgqgmgg ypsaisttyg teyslssadl sslsgfntas alhlgsvtgw qqqhlhnmpp
      361 salsqlgact sthlsqssnl slpstqslsi ksepvspprd rtttpsrypq httrheagrs
      421 pvdslsscss sydgsdredh rnefhspigl trpspderes psvkrmrlse gwat
//
LOCUS       NP_001350911             193 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-18-binding protein precursor [Mus musculus].
ACCESSION   NP_001350911
VERSION     NP_001350911.1
DBSOURCE    REFSEQ: accession NM_001363982.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 193)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   2  (residues 1 to 193)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 193)
  AUTHORS   Fauteux-Daniel,S., Merlo Pich,L.M., Girard-Guyonvarc'h,C.,
            Caruso,A., Rodriguez,E. and Gabay,C.
  TITLE     The role of interleukin-18 and interleukin-18 binding protein in
            K/BxN serum transfer-induced arthritis
  JOURNAL   Front Immunol 14, 1215364 (2023)
   PUBMED   37415987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 193)
  AUTHORS   Harel,M., Fauteux-Daniel,S., Rodriguez,E., Palmer,G. and Gabay,C.
  TITLE     IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine
            Macrophage Activation Syndrome
  JOURNAL   J Immunol 210 (11), 1790-1803 (2023)
   PUBMED   37074208
  REMARK    GeneRIF: IL-18 Binding Protein-Producing Cells Attenuate Anemia in
            Murine Macrophage Activation Syndrome.
REFERENCE   5  (residues 1 to 193)
  AUTHORS   Harel,M., Girard-Guyonvarc'h,C., Rodriguez,E., Palmer,G. and
            Gabay,C.
  TITLE     Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome
  JOURNAL   J Immunol 205 (4), 1167-1175 (2020)
   PUBMED   32651219
  REMARK    GeneRIF: Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
REFERENCE   6  (residues 1 to 193)
  AUTHORS   Banda,N.K., Vondracek,A., Kraus,D., Dinarello,C.A., Kim,S.H.,
            Bendele,A., Senaldi,G. and Arend,W.P.
  TITLE     Mechanisms of inhibition of collagen-induced arthritis by murine
            IL-18 binding protein
  JOURNAL   J Immunol 170 (4), 2100-2105 (2003)
   PUBMED   12574381
  REMARK    GeneRIF: Administratioan of murine IL-18BP at the time of the
            booster injection of bovine CII reduces the progressive severity of
            collagen-induced arthritis; both clinical disease activity and
            histological scores are decreased by 50%.
REFERENCE   7  (residues 1 to 193)
  AUTHORS   Kim,S.H., Eisenstein,M., Reznikov,L., Fantuzzi,G., Novick,D.,
            Rubinstein,M. and Dinarello,C.A.
  TITLE     Structural requirements of six naturally occurring isoforms of the
            IL-18 binding protein to inhibit IL-18
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1190-1195 (2000)
   PUBMED   10655506
REFERENCE   8  (residues 1 to 193)
  AUTHORS   Xiang,Y. and Moss,B.
  TITLE     Identification of human and mouse homologs of the MC51L-53L-54L
            family of secreted glycoproteins encoded by the Molluscum
            contagiosum poxvirus
  JOURNAL   Virology 257 (2), 297-302 (1999)
   PUBMED   10329540
REFERENCE   9  (residues 1 to 193)
  AUTHORS   Aizawa,Y., Akita,K., Taniai,M., Torigoe,K., Mori,T., Nishida,Y.,
            Ushio,S., Nukada,Y., Tanimoto,T., Ikegami,H., Ikeda,M. and
            Kurimoto,M.
  TITLE     Cloning and expression of interleukin-18 binding protein
  JOURNAL   FEBS Lett 445 (2-3), 338-342 (1999)
   PUBMED   10094485
REFERENCE   10 (residues 1 to 193)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5 and AK003370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003370.1, SRR5189679.170792.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..193
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     Protein         1..193
                     /product="interleukin-18-binding protein precursor"
                     /note="interferon gamma-inducing factor-binding protein"
                     /calculated_mol_wt=17976
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3299
     Region          47..169
                     /region_name="Pox_vIL-18BP"
                     /note="Orthopoxvirus interleukin 18 binding protein;
                     cl23951"
                     /db_xref="CDD:305108"
     CDS             1..193
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /coded_by="NM_001363982.1:202..783"
                     /db_xref="CCDS:CCDS21522.1"
                     /db_xref="GeneID:16068"
                     /db_xref="MGI:MGI:1333800"
ORIGIN      
        1 mtmrhcwtag psswwvllly vhvilarats apqttatvlt gsskdpcssw spavptkqyp
       61 aldviwpeke vplngtltls ctacsrfpyf silywlgngs fiehlpgrlk eghtsrehrn
      121 tstwlhralv leelsptlrs tnfsclfvdp gqvaqyhiil aqlwdglkta pspsqetlss
      181 hspvsrsagp gva
//
LOCUS       NP_083922                219 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-34 isoform 2 precursor [Mus musculus].
ACCESSION   NP_083922 XP_001003927 XP_001003931
VERSION     NP_083922.1
DBSOURCE    REFSEQ: accession NM_029646.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 219)
  AUTHORS   Van Hove,H., Gluck,C., Mildenberger,W., Petrova,E., Maheshwari,U.,
            Hane,P., Kreiner,V., Bijnen,M., Mussak,C., Utz,S.G., Droux,J.,
            Ingelfinger,F., Ashworth,C., Stifter,S.A., Roussel,E., Lelios,I.,
            Vermeer,M., Huang,S.F., Zhou,Q., Chen,Z., Calvet,C., Bourgeois,S.,
            Schaffenrath,J., Razansky,D., Juang,J.X., Asano,K., Pelczar,P.,
            Mundt,S., Weber,B., Wegener,S., Tugues,S., Stockmann,C., Becher,B.,
            Keller,A., El Amki,M. and Greter,M.
  TITLE     Interleukin-34-dependent perivascular macrophages promote vascular
            function in the brain
  JOURNAL   Immunity 58 (5), 1289-1305 (2025)
   PUBMED   40315842
REFERENCE   2  (residues 1 to 219)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   3  (residues 1 to 219)
  AUTHORS   Rayasam,A., Moe,A., Kudek,M., Shah,R.K., Yuan,C.Y., Miller,J.M.,
            Rau,M., Patton,M., Wanat,K., Colonna,M., Zamora,A.E. and
            Drobyski,W.R.
  TITLE     Intestinal epithelium-derived IL-34 reprograms macrophages to
            mitigate gastrointestinal tract graft-versus-host disease
  JOURNAL   Sci Transl Med 17 (785), eadn3963 (2025)
   PUBMED   39937882
REFERENCE   4  (residues 1 to 219)
  AUTHORS   Munoz-Garcia,J., Vargas-Franco,J.W., Schiavone,K., Keatinge,M.T.,
            Young,R., Amiaud,J., Fradet,L., Jegou,J.F., Yagita,H.,
            Blin-Wakkach,C., Wakkach,A., Cochonneau,D., Ollivier,E.,
            Pugiere,M., Henriquet,C., Legendre,M., Giurgea,I., Amselem,S.,
            Heymann,M.F., Teletchea,S., Lezot,F. and Heymann,D.
  TITLE     Interleukin-34 orchestrates bone formation through its binding to
            bone morphogenic proteins
  JOURNAL   Theranostics 15 (7), 3185-3202 (2025)
   PUBMED   40083929
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 219)
  AUTHORS   Nian,Z., Dou,Y., Shen,Y., Liu,J., Du,X., Jiang,Y., Zhou,Y., Fu,B.,
            Sun,R., Zheng,X., Tian,Z. and Wei,H.
  TITLE     Interleukin-34-orchestrated tumor-associated macrophage
            reprogramming is required for tumor immune escape driven by p53
            inactivation
  JOURNAL   Immunity 57 (10), 2344-2361 (2024)
   PUBMED   39321806
REFERENCE   6  (residues 1 to 219)
  AUTHORS   Chen,Z., Buki,K., Vaaraniemi,J., Gu,G. and Vaananen,H.K.
  TITLE     The critical role of IL-34 in osteoclastogenesis
  JOURNAL   PLoS One 6 (4), e18689 (2011)
   PUBMED   21494622
  REMARK    GeneRIF: This study was to explore the biological function,
            specifically osteoclastogenesis and bone metabolism, of il-34.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 219)
  AUTHORS   Chihara,T., Suzu,S., Hassan,R., Chutiwitoonchai,N., Hiyoshi,M.,
            Motoyoshi,K., Kimura,F. and Okada,S.
  TITLE     IL-34 and M-CSF share the receptor Fms but are not identical in
            biological activity and signal activation
  JOURNAL   Cell Death Differ 17 (12), 1917-1927 (2010)
   PUBMED   20489731
REFERENCE   8  (residues 1 to 219)
  AUTHORS   Wei,S., Nandi,S., Chitu,V., Yeung,Y.G., Yu,W., Huang,M.,
            Williams,L.T., Lin,H. and Stanley,E.R.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (residues 1 to 219)
  AUTHORS   Baud'huin,M., Renault,R., Charrier,C., Riet,A., Moreau,A.,
            Brion,R., Gouin,F., Duplomb,L. and Heymann,D.
  TITLE     Interleukin-34 is expressed by giant cell tumours of bone and plays
            a key role in RANKL-induced osteoclastogenesis
  JOURNAL   J Pathol 221 (1), 77-86 (2010)
   PUBMED   20191615
REFERENCE   10 (residues 1 to 219)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148512.1, AK008082.1 and AW743837.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_001003931.1, XP_001003927.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 3' coding region which results in a novel 3' coding region and
            3' UTR, compared to variant 1. It encodes isoform 2 which is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008082.1, SRR12282455.12957500.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.68 cM"
     Protein         1..219
                     /product="interleukin-34 isoform 2 precursor"
                     /calculated_mol_wt=22549
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2205
     Region          28..>153
                     /region_name="IL34"
                     /note="Interleukin 34; pfam15036"
                     /db_xref="CDD:434409"
     CDS             1..219
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /coded_by="NM_029646.3:584..1243"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS52670.1"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
ORIGIN      
        1 mpwglawlyc lgilldvalg nenleiwtlt qdkecdltgy lrgklqyknr lqymkhyfpi
       61 nyriavpyeg vlrvanitrl qkahvserel rylwvlvsln atesvmdvll eghpswkylq
      121 evqtllenvq rslmavgvhl pghvlvtlls qlpglpspwa rsfdtswell mmkgcgdwps
      181 rgscvissey srpkpeagaa qslagqllpg hgtavlfll
//
LOCUS       NP_034661                193 aa            linear   ROD 27-AUG-2025
DEFINITION  interleukin-18-binding protein precursor [Mus musculus].
ACCESSION   NP_034661
VERSION     NP_034661.1
DBSOURCE    REFSEQ: accession NM_010531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 193)
  AUTHORS   Mertens,R.T., Misra,A., Xiao,P., Baek,S., Rone,J.M., Mangani,D.,
            Sivanathan,K.N., Arojojoye,A.S., Awuah,S.G., Lee,I., Shi,G.P.,
            Petrova,B., Brook,J.R., Anderson,A.C., Flavell,R.A., Kanarek,N.,
            Hemberg,M. and Nowarski,R.
  TITLE     A metabolic switch orchestrated by IL-18 and the cyclic
            dinucleotide cGAMP programs intestinal tolerance
  JOURNAL   Immunity 57 (9), 2077-2094 (2024)
   PUBMED   38906145
REFERENCE   2  (residues 1 to 193)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 193)
  AUTHORS   Fauteux-Daniel,S., Merlo Pich,L.M., Girard-Guyonvarc'h,C.,
            Caruso,A., Rodriguez,E. and Gabay,C.
  TITLE     The role of interleukin-18 and interleukin-18 binding protein in
            K/BxN serum transfer-induced arthritis
  JOURNAL   Front Immunol 14, 1215364 (2023)
   PUBMED   37415987
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 193)
  AUTHORS   Harel,M., Fauteux-Daniel,S., Rodriguez,E., Palmer,G. and Gabay,C.
  TITLE     IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine
            Macrophage Activation Syndrome
  JOURNAL   J Immunol 210 (11), 1790-1803 (2023)
   PUBMED   37074208
  REMARK    GeneRIF: IL-18 Binding Protein-Producing Cells Attenuate Anemia in
            Murine Macrophage Activation Syndrome.
REFERENCE   5  (residues 1 to 193)
  AUTHORS   Harel,M., Girard-Guyonvarc'h,C., Rodriguez,E., Palmer,G. and
            Gabay,C.
  TITLE     Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome
  JOURNAL   J Immunol 205 (4), 1167-1175 (2020)
   PUBMED   32651219
  REMARK    GeneRIF: Production of IL-18 Binding Protein by Radiosensitive and
            Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
REFERENCE   6  (residues 1 to 193)
  AUTHORS   Banda,N.K., Vondracek,A., Kraus,D., Dinarello,C.A., Kim,S.H.,
            Bendele,A., Senaldi,G. and Arend,W.P.
  TITLE     Mechanisms of inhibition of collagen-induced arthritis by murine
            IL-18 binding protein
  JOURNAL   J Immunol 170 (4), 2100-2105 (2003)
   PUBMED   12574381
  REMARK    GeneRIF: Administratioan of murine IL-18BP at the time of the
            booster injection of bovine CII reduces the progressive severity of
            collagen-induced arthritis; both clinical disease activity and
            histological scores are decreased by 50%.
REFERENCE   7  (residues 1 to 193)
  AUTHORS   Kim,S.H., Eisenstein,M., Reznikov,L., Fantuzzi,G., Novick,D.,
            Rubinstein,M. and Dinarello,C.A.
  TITLE     Structural requirements of six naturally occurring isoforms of the
            IL-18 binding protein to inhibit IL-18
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1190-1195 (2000)
   PUBMED   10655506
REFERENCE   8  (residues 1 to 193)
  AUTHORS   Xiang,Y. and Moss,B.
  TITLE     Identification of human and mouse homologs of the MC51L-53L-54L
            family of secreted glycoproteins encoded by the Molluscum
            contagiosum poxvirus
  JOURNAL   Virology 257 (2), 297-302 (1999)
   PUBMED   10329540
REFERENCE   9  (residues 1 to 193)
  AUTHORS   Aizawa,Y., Akita,K., Taniai,M., Torigoe,K., Mori,T., Nishida,Y.,
            Ushio,S., Nukada,Y., Tanimoto,T., Ikegami,H., Ikeda,M. and
            Kurimoto,M.
  TITLE     Cloning and expression of interleukin-18 binding protein
  JOURNAL   FEBS Lett 445 (2-3), 338-342 (1999)
   PUBMED   10094485
REFERENCE   10 (residues 1 to 193)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5 and AF122907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF122907.1, SRR5189682.27629.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..193
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     Protein         1..193
                     /product="interleukin-18-binding protein precursor"
                     /note="interferon gamma-inducing factor-binding protein"
                     /calculated_mol_wt=17976
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3299
     Region          47..169
                     /region_name="Pox_vIL-18BP"
                     /note="Orthopoxvirus interleukin 18 binding protein;
                     cl23951"
                     /db_xref="CDD:305108"
     CDS             1..193
                     /gene="Il18bp"
                     /gene_synonym="Igifbp; IL-18BP; MC54L"
                     /coded_by="NM_010531.2:229..810"
                     /db_xref="CCDS:CCDS21522.1"
                     /db_xref="GeneID:16068"
                     /db_xref="MGI:MGI:1333800"
ORIGIN      
        1 mtmrhcwtag psswwvllly vhvilarats apqttatvlt gsskdpcssw spavptkqyp
       61 aldviwpeke vplngtltls ctacsrfpyf silywlgngs fiehlpgrlk eghtsrehrn
      121 tstwlhralv leelsptlrs tnfsclfvdp gqvaqyhiil aqlwdglkta pspsqetlss
      181 hspvsrsagp gva
//
LOCUS       NP_001278163            1504 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 1 isoform d [Mus musculus].
ACCESSION   NP_001278163 XP_006504418
VERSION     NP_001278163.1
DBSOURCE    REFSEQ: accession NM_001291234.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1504)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1504)
  AUTHORS   Kofuji,S., Qian,Y. and Nishina,H.
  TITLE     Region-specific roles of stress-activated protein kinase MKK7 in
            the developing and maturing murine brain
  JOURNAL   Sci Rep 15 (1), 20504 (2025)
   PUBMED   40594443
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1504)
  AUTHORS   Kawamura,A., Fujii,K., Tamada,K., Abe,Y., Nitahara,K., Iwasaki,T.,
            Yagishita,S., Tanaka,K.F., Takumi,T., Takao,K. and Nishiyama,M.
  TITLE     Duplication of the autism-related gene Chd8 leads to behavioral
            hyperactivity and neurodevelopmental defects in mice
  JOURNAL   Nat Commun 16 (1), 4641 (2025)
   PUBMED   40419468
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1504)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1504)
  AUTHORS   Gillingham,A.K., Pfeifer,A.C. and Munro,S.
  TITLE     CASP, the alternatively spliced product of the gene encoding the
            CCAAT-displacement protein transcription factor, is a Golgi
            membrane protein related to giantin
  JOURNAL   Mol Biol Cell 13 (11), 3761-3774 (2002)
   PUBMED   12429822
REFERENCE   6  (residues 1 to 1504)
  AUTHORS   Lievens,P.M., Tufarelli,C., Donady,J.J., Stagg,A. and Neufeld,E.J.
  TITLE     CASP, a novel, highly conserved alternative-splicing product of the
            CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains,
            and interacts with full-length CDP in vitro
  JOURNAL   Gene 197 (1-2), 73-81 (1997)
   PUBMED   9332351
REFERENCE   7  (residues 1 to 1504)
  AUTHORS   Mailly,F., Berube,G., Harada,R., Mao,P.L., Phillips,S. and
            Nepveu,A.
  TITLE     The human cut homeodomain protein can repress gene expression by
            two distinct mechanisms: active repression and competition for
            binding site occupancy
  JOURNAL   Mol Cell Biol 16 (10), 5346-5357 (1996)
   PUBMED   8816446
REFERENCE   8  (residues 1 to 1504)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1504)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
REFERENCE   10 (residues 1 to 1504)
  AUTHORS   Andres,V., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Clox, a mammalian homeobox gene related to Drosophila cut, encodes
            DNA-binding regulatory proteins differentially expressed during
            development
  JOURNAL   Development 116 (2), 321-334 (1992)
   PUBMED   1363085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087329.10, AC080158.4 and AC083890.4.
            
            On Mar 29, 2014 this sequence version replaced XP_006504418.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220173.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.96 cM"
     Protein         1..1504
                     /product="homeobox protein cut-like 1 isoform d"
                     /note="protein CASP; homeobox protein cut-like 1; CCAAT
                     displacement protein; Cux/CDP homeoprotein; homeobox
                     protein cux-1"
                     /calculated_mol_wt=164373
     Region          16..>192
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          <107..375
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          556..632
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          734..>917
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          923..991
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1106..1183
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1229..1285
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..1504
                     /gene="Cux1"
                     /gene_synonym="CDP; Cutl1; Cux; Cux-1"
                     /coded_by="NM_001291234.2:24..4538"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS71684.1"
                     /db_xref="GeneID:13047"
                     /db_xref="MGI:MGI:88568"
ORIGIN      
        1 maanvgsmfq ywkrfdlqql qreldatatv lanrqdeseq srkrlieqsr efkkntpedl
       61 rkqvapllks fqgeidalsk rskeaeaafl tvykrlidvp dpvpaldvgq qleikvqrlh
      121 dietenqklr etleeynkef aevknqevti kalkekirey eqtlksqaet ialekeqklq
      181 ndfaekerkl qetqmsttsk leeaehklqt lqtalektrt elfdlktkyd eettakadei
      241 emimtdlera nqraevaqre aetlreqlss anhslqlasq iqkapdvaie vltrssleve
      301 laakereiaq lvedvqrlqa sltklrensa sqisqleqql naknstlkql eeklkgqady
      361 eevkkelntl ksmefapseg agtqdstkpl evllleknrs lqsenatlri snsdlsgsar
      421 rkgrdqpesr rpgplpaspp pqlprntgeq vsntngthhf spaglsqdff ssnlaspslp
      481 lastgkfaln sllqrqlmqs fyskamqeag ststifstgp ystnsissps plqqspdvng
      541 mapspsqses agsisegeei dtaeiarqvk eqlikhnigq rifghyvlgl sqgsvseila
      601 rpkpwnkltv rgkepfhkmk qflsdeqnil alrsiqgrqr gnittriras etgsdeaiks
      661 ileqakrelq vqktaepvqt sstsssgnsd dairsilqqa rremeaqqaa ldpalkpapl
      721 sqpdltiltp khlsaspmst vstypplais lkktpaapet staalpsapa lkkeaqdvpt
      781 ldppgsadaa qgvlrpmkse lvrgstwkdp wwspiqperr nltsseetka dettasgker
      841 agssqpraer sqlqgpsasa eywkewpsae spysqssels ltgasrsetp qnsplpsspi
      901 vpmakpakps vppltpeqye vymyqevdti eltrqvkekl akngicqrif gekvlglsqg
      961 svsdmlsrpk pwskltqkgr epfirmqlwl ngelgqgvlp vqgqqqgpvl hsvaslqdpl
     1021 qqgcvssest pktsascspa pespmssses vksltelvqq pcpaietske gkppepsdpp
     1081 asdsqpttpl plsghsalsi qelvamspel dtygitkrvk evltdnnlgq rlfgetilgl
     1141 tqgsvsdlla rpkpwhklsl kgrepfvrmq lwlndpnnve klmdmkrmek kaymkrrhss
     1201 vsdsqpcepp svgidysqga spqpqhqlkk prvvlapeek ealkrayqqk pypspktiee
     1261 latqlnlkts tvinwfhnyr srirrelfie eiqagsqgqa gasdspsars sraapssegd
     1321 scdgveatda eepggnivat ksqgglaeva aapadreeat qpaekakaqp lcsgtpgqdd
     1381 gedasrprpl pegladapap vpslaapaag edaatsatap atateapgaa ragpaerssa
     1441 lpstsapana parrpsslqs lfglpeaaga rdnlvrkkka anlnsiihrl ekaasreepi
     1501 ewef
//
LOCUS       NP_061351                248 aa            linear   ROD 27-AUG-2025
DEFINITION  proenkephalin-B preproprotein [Mus musculus].
ACCESSION   NP_061351
VERSION     NP_061351.2
DBSOURCE    REFSEQ: accession NM_018863.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 248)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   2  (residues 1 to 248)
  AUTHORS   Grady,F.S., Graff,S.A., Warnock,M.M., Gasparini,S., Tish,M.M.,
            Li,Y., Buchanan,G.F., Resch,J.M. and Geerling,J.C.
  TITLE     Parabrachial Foxp2-expressing neurons are necessary for sustaining
            core body temperature in the cold
  JOURNAL   iScience 28 (8), 112764 (2025)
   PUBMED   40703448
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 248)
  AUTHORS   Bryant,K.G., Swygart,D., Yin,Y., Bauer,M.R., Morningstar,M.D.,
            Timme,N.M., Barnett,W.H., McGonigle,C.E., Engleman,E.A.,
            Sheets,P.L. and Lapish,C.C.
  TITLE     Acute alcohol in prefrontal cortex is characterized by enhanced
            inhibition that transitions to excitation
  JOURNAL   iScience 28 (7), 112920 (2025)
   PUBMED   40687835
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 248)
  AUTHORS   Wittmann,W., Schunk,E., Rosskothen,I., Gaburro,S., Singewald,N.,
            Herzog,H. and Schwarzer,C.
  TITLE     Prodynorphin-derived peptides are critical modulators of anxiety
            and regulate neurochemistry and corticosterone
  JOURNAL   Neuropsychopharmacology 34 (3), 775-785 (2009)
   PUBMED   18800067
  REMARK    GeneRIF: our data suggest a pronounced impact of endogenous
            prodynorphin-derived peptides on anxiety, but not stress coping
            ability and that these effects are mediated via kappa-opioid
            receptors.
REFERENCE   5  (residues 1 to 248)
  AUTHORS   Kuzmin,A., Madjid,N., Terenius,L., Ogren,S.O. and Bakalkin,G.
  TITLE     Big dynorphin, a prodynorphin-derived peptide produces NMDA
            receptor-mediated effects on memory, anxiolytic-like and locomotor
            behavior in mice
  JOURNAL   Neuropsychopharmacology 31 (9), 1928-1937 (2006)
   PUBMED   16292317
REFERENCE   6  (residues 1 to 248)
  AUTHORS   Sharifi,N., Ament,M., Brennan,M.B. and Hochgeschwender,U.
  TITLE     Isolation and characterization of the mouse homolog of the
            preprodynorphin (Pdyn) gene
  JOURNAL   Neuropeptides 33 (3), 236-238 (1999)
   PUBMED   10657497
REFERENCE   7  (residues 1 to 248)
  AUTHORS   Albrecht,U., Sutcliffe,J.S., Cattanach,B.M., Beechey,C.V.,
            Armstrong,D., Eichele,G. and Beaudet,A.L.
  TITLE     Imprinted expression of the murine Angelman syndrome gene, Ube3a,
            in hippocampal and Purkinje neurons
  JOURNAL   Nat Genet 17 (1), 75-78 (1997)
   PUBMED   9288101
REFERENCE   8  (residues 1 to 248)
  AUTHORS   Erwin,V.G., Markel,P.D., Johnson,T.E., Gehle,V.M. and Jones,B.C.
  TITLE     Common quantitative trait loci for alcohol-related behaviors and
            central nervous system neurotensin measures: hypnotic and
            hypothermic effects
  JOURNAL   J Pharmacol Exp Ther 280 (2), 911-918 (1997)
   PUBMED   9023306
REFERENCE   9  (residues 1 to 248)
  AUTHORS   Giros,B., Pohl,M., Rochelle,J.M. and Seldin,M.F.
  TITLE     Chromosomal localization of opioid peptide and receptor genes in
            the mouse
  JOURNAL   Life Sci 56 (18), PL369-PL375 (1995)
   PUBMED   7752808
REFERENCE   10 (residues 1 to 248)
  AUTHORS   Gulya,K., Orpana,A.K., Sikela,J.M. and Hoffman,P.L.
  TITLE     Prodynorphin and vasopressin mRNA levels are differentially
            affected by chronic ethanol ingestion in the mouse
  JOURNAL   Brain Res Mol Brain Res 20 (1-2), 1-8 (1993)
   PUBMED   8255170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK133597.1, AL808137.4 and
            BB421226.1.
            
            On Jun 10, 2007 this sequence version replaced NP_061351.1.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            cleaved to yield a number of active opium-like peptides. These
            peptides are the endogenous ligands for the Kappa-opioid receptor
            and similar G-protein-coupled receptors and are thought to function
            as the body's natural way to control addiction. These peptides have
            been associated with depression, stress, anxiety, response to pain,
            and maintenance of homeostasis via circadian rhythms and control of
            appetite. Mutations in the related human gene have been linked to
            the neurodegenerative disease spinocerebellar ataxia. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133597.1, AF026537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.19 cM"
     Protein         1..248
                     /product="proenkephalin-B preproprotein"
                     /note="proenkephalin-B; preprodynorphin;
                     beta-neoendorphin-dynorphin; alpha-neoendorphin;
                     leu-enkephalin; big dynorphin; dynorphin A(1-17);
                     dynorphin A(1-13); dynorphin A(1-8); leumorphin;
                     rimorphin"
                     /calculated_mol_wt=25719
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2309
     proprotein      22..248
                     /product="proenkephalin-B proprotein"
                     /calculated_mol_wt=25719
     Region          22..68
                     /region_name="Opiods_neuropep"
                     /note="Vertebrate endogenous opioids neuropeptide;
                     pfam01160"
                     /db_xref="CDD:426090"
     mat_peptide     166..175
                     /product="alpha-neoendorphin"
                     /calculated_mol_wt=1228
     mat_peptide     166..174
                     /product="beta-neoendorphin"
                     /calculated_mol_wt=1100
     mat_peptide     166..170
                     /product="leu-enkephalin"
                     /calculated_mol_wt=556
     mat_peptide     202..233
                     /product="big dynorphin"
                     /calculated_mol_wt=3985
     mat_peptide     202..218
                     /product="dynorphin A(1-17)"
                     /calculated_mol_wt=2148
     mat_peptide     202..214
                     /product="dynorphin A(1-13)"
                     /calculated_mol_wt=1604
     mat_peptide     202..209
                     /product="dynorphin A(1-8)"
                     /calculated_mol_wt=981
     mat_peptide     202..206
                     /product="leu-enkephalin"
                     /calculated_mol_wt=556
     mat_peptide     221..248
                     /product="leumorphin"
                     /calculated_mol_wt=3320
     mat_peptide     221..233
                     /product="rimorphin"
                     /calculated_mol_wt=1571
     mat_peptide     221..225
                     /product="leu-enkephalin"
                     /calculated_mol_wt=556
     CDS             1..248
                     /gene="Pdyn"
                     /gene_synonym="Dyn"
                     /coded_by="NM_018863.4:309..1055"
                     /db_xref="CCDS:CCDS38239.1"
                     /db_xref="GeneID:18610"
                     /db_xref="MGI:MGI:97535"
ORIGIN      
        1 mawsrlmlaa cllvmpsnvm adclslcslc avriqdgprp inplicslec qdlvppseew
       61 etcrgfssfl tltvsglrgk ddledevale egysalakll epvlkeleks rlltsvpeek
      121 frglsssfgn gkeselagad rmndeaaqag tlhfneedlr kqakryggfl rkypkrssem
      181 ardedggqdg dqvghedlyk ryggflrrir pklkwdnqkr yggflrrqfk vvtrsqenpn
      241 tysedldv
//
LOCUS       NP_001399546             206 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform b [Mus musculus].
ACCESSION   NP_001399546 XP_017172249
VERSION     NP_001399546.1
DBSOURCE    REFSEQ: accession NM_001412617.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            On Oct 12, 2022 this sequence version replaced XP_017172249.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3224864.6827.1,
                                           SRR9219381.17202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..206
                     /product="synaptosomal-associated protein 25 isoform b"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=23205
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..142
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          143..201
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(143,145..146,149..154,156..157,160..161,163..165,
                     167..168,171..172,174..175,177..182,184..185,188,191,195,
                     198,201)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            174
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     CDS             1..206
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001412617.1:139..759"
                     /note="isoform b is encoded by transcript variant 8"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqldrv
       61 eegmnhinqd mkeaeknlkd lgkccglfic pcnklkssda ykkawgnnqd gvvasqparv
      121 vdereqmais ggfirrvtnd arenemdenl eqvsgiignl rhmaldmgne idtqnrqidr
      181 imekadsnkt rideanqrat kmlgsg
//
LOCUS       NP_001396740             751 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 3 [Mus musculus].
ACCESSION   NP_001396740 XP_006505583
VERSION     NP_001396740.1
DBSOURCE    REFSEQ: accession NM_001409811.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 751)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 751)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 751)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 751)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 751)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 751)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 751)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 751)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 751)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 751)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 22, 2022 this sequence version replaced XP_006505583.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1802608.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..751
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     3"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=85789
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Site            75
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          158..249
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          180..217
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          334..527
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          345..431
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            371
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            372
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          564..595
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          614..733
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(618,620..623,625,629,632,634,684..685,688,708,724)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(626..629,646,653,656..657,660,664,667..673,690..694,
                     702,729,731..732)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..694,731)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(628..629,662..663,666,668,670,683,690..693)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(646,653,656..657,660,664,669,671..673,702,729,
                     731..733)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..751
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409811.1:101..2356"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtsvsslrgt recsvtsdld fpaqviplkt lnavasvpim yswsplqqnf
      121 mvedetvlhn ipymgdevld qdgtfieeli knydgkvhgd recgfindei fvelvnalgq
      181 yndddddddg ddpdereekq kdlednrddk etcpprkfpa dkifeaissm fpdkgtaeel
      241 kekykelteq qlpgalppec tpnidgpnak svqreqslhs fhtlfcrrcf kydcflhrkc
      301 sysfhatpnt ykrkntetal dnkpcgpqcy qhlegakefa aaltaerikt ppkrpggrrr
      361 grlpnnssrp stptisvles kdtdsdreag tetggenndk eeeekkdets ssseansrcq
      421 tpikmkpnie ppenvewsga easmfrvlig tyydnfcaia rligtktcrq vyefrvkess
      481 iiapvptedv dtpprkkkrk hrlwaahcrk iqlkkdgssn hvynyqpcdh prqpcdsscp
      541 cviaqnfcek fcqcssecqn rfpgcrckaq cntkqcpcyl avrecdpdlc ltcgaadhwd
      601 sknvsckncs iqrgskkhll lapsdvagwg ifikdpvqkn efiseycgei isqdeadrrg
      661 kvydkymcsf lfnlnndfvv datrkgnkir fanhsvnpnc yakvmmvngd hrigifakra
      721 iqtgeelffd yrysqadalk yvgieremei p
//
LOCUS       NP_001171466            1177 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase PRDM16 isoform 2 [Mus musculus].
ACCESSION   NP_001171466
VERSION     NP_001171466.1
DBSOURCE    REFSEQ: accession NM_001177995.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1177)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1177)
  AUTHORS   Fu,L., Upadhyay,R., Pokrovskii,M., Chen,F.M., Romero-Meza,G.,
            Griesemer,A. and Littman,D.R.
  TITLE     PRDM16-dependent antigen-presenting cells induce tolerance to gut
            antigens
  JOURNAL   Nature 642 (8068), 756-765 (2025)
   PUBMED   40228524
REFERENCE   3  (residues 1 to 1177)
  AUTHORS   Zhang,H., Papiernik,T., Tian,S., Yaghmour,A., Alzein,A.,
            Lennon,J.B., Maini,R., Tan,X., Niazi,A., Park,J., Park,S.,
            Richter,C.P. and Ebeid,M.
  TITLE     Kolliker's Organ Functions as a Developmental Hub in Mouse Cochlea
            Regulating Spiral Limbus and Tectorial Membrane Development
  JOURNAL   J Neurosci 45 (13), e0721242025 (2025)
   PUBMED   39909560
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1177)
  AUTHORS   Wang,S., He,T., Luo,Y., Ren,K., Shen,H., Hou,L., Wei,Y., Fu,T.,
            Xie,W., Wang,P., Hu,J., Zhu,Y., Huang,Z., Li,Q., Li,W., Guo,H. and
            Li,B.
  TITLE     SOX4 facilitates brown fat development and maintenance through
            EBF2-mediated thermogenic gene program in mice
  JOURNAL   Cell Death Differ 32 (3), 447-465 (2025)
   PUBMED   39402212
REFERENCE   5  (residues 1 to 1177)
  AUTHORS   Wang,Y., Li,X., Liu,C., Zhou,L., Shi,L., Zhang,Z., Chen,L., Gao,M.,
            Gao,L., Xu,Y., Huang,H., Li,J. and Chen,Z.
  TITLE     WTAP regulates postnatal development of brown adipose tissue by
            stabilizing METTL3 in mice
  JOURNAL   Life Metab 1 (3), 270-284 (2022)
   PUBMED   39872074
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1177)
  AUTHORS   Seale,P., Kajimura,S., Yang,W., Chin,S., Rohas,L.M., Uldry,M.,
            Tavernier,G., Langin,D. and Spiegelman,B.M.
  TITLE     Transcriptional control of brown fat determination by PRDM16
  JOURNAL   Cell Metab 6 (1), 38-54 (2007)
   PUBMED   17618855
REFERENCE   7  (residues 1 to 1177)
  AUTHORS   Warner,D.R., Horn,K.H., Mudd,L., Webb,C.L., Greene,R.M. and
            Pisano,M.M.
  TITLE     PRDM16/MEL1: a novel Smad binding protein expressed in murine
            embryonic orofacial tissue
  JOURNAL   Biochim Biophys Acta 1773 (6), 814-820 (2007)
   PUBMED   17467076
  REMARK    GeneRIF: PRDM16/MEL1 is a Smad binding protein that may be
            important for development of orofacial structures through
            modulation of the TGFbeta signaling pathway.
REFERENCE   8  (residues 1 to 1177)
  AUTHORS   Du,Y., Jenkins,N.A. and Copeland,N.G.
  TITLE     Insertional mutagenesis identifies genes that promote the
            immortalization of primary bone marrow progenitor cells
  JOURNAL   Blood 106 (12), 3932-3939 (2005)
   PUBMED   16109773
REFERENCE   9  (residues 1 to 1177)
  AUTHORS   Nishikata,I., Sasaki,H., Iga,M., Tateno,Y., Imayoshi,S., Asou,N.,
            Nakamura,T. and Morishita,K.
  TITLE     A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is
            expressed mainly in t(1;3)(p36;q21)-positive AML and blocks
            G-CSF-induced myeloid differentiation
  JOURNAL   Blood 102 (9), 3323-3332 (2003)
   PUBMED   12816872
REFERENCE   10 (residues 1 to 1177)
  AUTHORS   Herron,B.J., Lu,W., Rao,C., Liu,S., Peters,H., Bronson,R.T.,
            Justice,M.J., McDonald,J.D. and Beier,D.R.
  TITLE     Efficient generation and mapping of recessive developmental
            mutations using ENU mutagenesis
  JOURNAL   Nat Genet 30 (2), 185-189 (2002)
   PUBMED   11818962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627127.20, AL611950.17, AL627226.16 and AL627123.13.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053082.1, SRR13861889.80232.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.96 cM"
     Protein         1..1177
                     /product="histone-lysine N-methyltransferase PRDM16
                     isoform 2"
                     /EC_number="2.1.1.367"
                     /note="transcription factor MEL1; MDS1/EVI1-like gene 1;
                     PR domain-containing protein 16; PR domain zinc finger
                     protein 16; line 27; histone-lysine N-methyltransferase
                     PRDM16"
                     /calculated_mol_wt=130210
     Region          1..66
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          61..223
                     /region_name="PR-SET_PRDM16"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 16 (PRDM16) and similar proteins; cd19213"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,113,158,171..175,177,186..187,211)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380990"
     Site            order(91,94..96,171..175,177,211)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380990"
     Region          233..253
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          283..305
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          285..305
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(290,292,294,296..297,300..301,304,318,320,324..325,
                     328..329,332,346,348,350,352..353,356..357)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          297..321
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          311..333
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          313..333
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          339..360
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          341..359
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          368..390
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          370..390
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          396..418
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          398..418
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          427..445
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          593..659
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          681..1039
                     /region_name="Interaction with CTBP1, CTBP2 and ZNF516.
                     /evidence=ECO:0000269|PubMed:18483224"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          790..839
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          952..974
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          954..974
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(959,961,963,965..966,969..970,973,987,989,993..994,
                     997..998,1002,1016,1018,1020,1022..1023,1026..1027,1030)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          966..990
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          982..>1016
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          982..1008
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          982..1003
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(987,993,1005,1007,1010)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          1009..1031
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          1011..1031
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1028..1066
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     Region          1085..1170
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A935.1)"
     CDS             1..1177
                     /gene="Prdm16"
                     /gene_synonym="5730557K01Rik; csp1; mel1"
                     /coded_by="NM_001177995.2:58..3591"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS51400.1"
                     /db_xref="GeneID:70673"
                     /db_xref="MGI:MGI:1917923"
ORIGIN      
        1 mrskararkl aksdgdvvnn myepdpdlla gqsaeeeted gilspipmgp pspfptsedf
       61 tpkegspyea pvyipedipi ppdfelress ipgaglgiwa krkmeigerf gpyvvtpraa
      121 lkeadfgweq mltdtevssq escikkqise dlgsekfcvd anqagsgswl kyirvacscd
      181 dqnlamcqin eqiyykvikd iepgeellvh vkegayslgv mapsldedpt frcdecdelf
      241 qcrldlrrhk kyacssagaq lyeglgeelk peglgvgsdg qaheckdcer mfpnkysleq
      301 hmivhteere ykcdqcpkaf nwksnlirhq mshdsgkrfe cencvkvftd psnlqrhirs
      361 qhvgarahac pdcgktfats sglkqhkhih stvkpficev chksytqfsn lcrhkrmhad
      421 crtqikckdc gqmfsttssl nkhrrfcegk nhytpgsift pglpltpspm mdktkpsptl
      481 nhgglgfsey fpsrphpgsl pfsaappafp altpgfpgif ppslyprppl lpptpllksp
      541 lnhaqdaklp splgnpalpl vsavsnssqg ataatgseek fdgrledaya ekvknrspdm
      601 sdgsdfedin tttgtdldtt tgtgsdldsd ldsdrdkgkd kgkpveskpe fggasvppga
      661 mnsvaevpaf ysqhsffppp eeqlltasga agdsikaias iaekyfgpgf msmqekklgs
      721 lpyhsvfpfq flpnfphsly pftdralahn llvkaepksp rdalkvggps aecpfdlttk
      781 pkeakpalla pkvplipssg eeqpldlsig srarasqngg greprknhvy gerkpgvseg
      841 lpkvcpaqlp qqpslhyakp spffmdpiyr vekrkvadpv gvlkekylrp spllfhpqms
      901 aietmtekle sfaamkadsg sslqplphhp fnfrsppptl sdpilrkgke rytcrycgki
      961 fprsanltrh lrthtgeqpy rckycdrsfs issnlqrhvr nihnkekpfk chlcnrcfgq
     1021 qtnldrhlkk hehegapvsq hsgvltnhlg tsassptses dnhalldeke dsyfseirnf
     1081 iansemnqas trmdkrpeiq dldsnppcpg sasakpedve eeeeeeleee dddslagksq
     1141 edtvsptpep qgvyedeede eppsltmgfd htrrhmq
//
LOCUS       NP_032255                488 aa            linear   ROD 27-AUG-2025
DEFINITION  histone deacetylase 2 isoform a [Mus musculus].
ACCESSION   NP_032255 XP_998855
VERSION     NP_032255.2
DBSOURCE    REFSEQ: accession NM_008229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Zrimsek,M., Draganic,K., Malzer,A., Doblmayr,V., Misura,K., de
            Freitas E Silva,R., Matthews,J.D., Iannelli,F., Wohlhaupter,S.,
            Perez Malla,C.U., Fischer,H., Schachner,H., Schiefer,A.I.,
            Sheibani-Tezerji,R., Chiarle,R., Turner,S.D., Ellmeier,W.,
            Seiser,C. and Egger,G.
  TITLE     HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large
            cell lymphoma: implications for HDAC inhibitor therapy
  JOURNAL   Leukemia 39 (6), 1412-1424 (2025)
   PUBMED   40175628
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Iwamura,Y., Nakai,T., Kato,K., Ishioka,H., Yamamoto,M., Hirano,I.
            and Suzuki,N.
  TITLE     Erythropoietin Production in Embryonic Neural Cells is Controlled
            by Hypoxia Signaling and Histone Deacetylases with an
            Undifferentiated Cellular State
  JOURNAL   Mol Cell Biol 45 (1), 32-45 (2025)
   PUBMED   39620278
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Zeng,Y., Tang,C.M., Yao,Y.L., Yang,W.M. and Seto,E.
  TITLE     Cloning and characterization of the mouse histone deacetylase-2
            gene
  JOURNAL   J Biol Chem 273 (44), 28921-28930 (1998)
   PUBMED   9786895
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Laherty,C.D., Billin,A.N., Lavinsky,R.M., Yochum,G.S., Bush,A.C.,
            Sun,J.M., Mullen,T.M., Davie,J.R., Rose,D.W., Glass,C.K.,
            Rosenfeld,M.G., Ayer,D.E. and Eisenman,R.N.
  TITLE     SAP30, a component of the mSin3 corepressor complex involved in
            N-CoR-mediated repression by specific transcription factors
  JOURNAL   Mol Cell 2 (1), 33-42 (1998)
   PUBMED   9702189
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Yang,W.M., Inouye,C., Zeng,Y., Bearss,D. and Seto,E.
  TITLE     Transcriptional repression by YY1 is mediated by interaction with a
            mammalian homolog of the yeast global regulator RPD3
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12845-12850 (1996)
   PUBMED   8917507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165734.1, U31758.1 and AB221663.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_998855.1, NP_032255.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.142827.1, U31758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 19.44 cM"
     Protein         1..488
                     /product="histone deacetylase 2 isoform a"
                     /EC_number="3.5.1.98"
                     /note="HD2; YY1 transcription factor-binding protein;
                     protein deacylase HDAC2"
                     /calculated_mol_wt=55199
     Region          9..374
                     /region_name="HDAC2"
                     /note="Histone deacetylase 2 (HDAC2); cd10011"
                     /db_xref="CDD:212535"
     Region          9..322
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (P70288.1)"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (P70288.1)"
     Site            order(141..142,150..151,177,179,265,272,302,304)
                     /site_type="active"
                     /db_xref="CDD:212535"
     Site            221
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13547; propagated from
                     UniProtKB/Swiss-Prot (P70288.1)"
     Region          389..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70288.1)"
     Site            394
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70288.1)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92769; propagated from
                     UniProtKB/Swiss-Prot (P70288.1)"
     Site            422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70288.1)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326; propagated from
                     UniProtKB/Swiss-Prot (P70288.1)"
     CDS             1..488
                     /gene="Hdac2"
                     /gene_synonym="D10Wsu179e; mRPD3; YAF1; Yy1bp"
                     /coded_by="NM_008229.2:209..1675"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23783.1"
                     /db_xref="GeneID:15182"
                     /db_xref="MGI:MGI:1097691"
ORIGIN      
        1 maysqgggkk kvcyyydgdi gnyyygqghp mkphrirmth nlllnyglyr kmeiyrphka
       61 taeemtkyhs deyikflrsi rpdnmseysk qmqrfnvged cpvfdglfef cqlstggsva
      121 gavklnrqqt dmavnwaggl hhakkseasg fcyvndivla ilellkyhqr vlyididihh
      181 gdgveeafyt tdrvmtvsfh kygeyfpgtg dlrdigagkg kyyavnfpmr dgiddesygq
      241 ifkpiiskvm emyqpsavvl qcgadslsgd rlgcfnltvk ghakcvevvk tfnlpllmlg
      301 gggytirnva rcwtyetava ldceipnelp yndyfeyfgp dfklhispsn mtnqntpeym
      361 ekikqrlfen lrmlphapgv qmqaipedav hedsgdedge dpdkrisira sdkriacdee
      421 fsdsedegeg grrnvadhkk gakkarieed kketedkktd vkeedkskdn sgektdpkga
      481 kseqlsnp
//
LOCUS       NP_001407283             414 aa            linear   ROD 27-AUG-2025
DEFINITION  LIM/homeobox protein Lhx2 isoform c [Mus musculus].
ACCESSION   NP_001407283 XP_006497796
VERSION     NP_001407283.1
DBSOURCE    REFSEQ: accession NM_001420354.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 414)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 414)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 414)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 414)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 414)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (residues 1 to 414)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 414)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 414)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 414)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 414)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            On May 2, 2023 this sequence version replaced XP_006497796.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.481823.1,
                                           SRR14777530.575027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..414
                     /product="LIM/homeobox protein Lhx2 isoform c"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=45101
     Region          43..106
                     /region_name="LIM1_Lhx2"
                     /note="The first LIM domain of Lhx2; cd09469"
                     /db_xref="CDD:188853"
     Site            order(53,56,74,77,80,83,102,105)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188853"
     Region          119..177
                     /region_name="LIM2_Lhx2_Lhx9"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     cd09377"
                     /db_xref="CDD:188763"
     Site            order(123,126,145,148,151,154,173,176)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188763"
     Region          <255..386
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          258..278
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S2.1)"
     Region          275..331
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          315..331
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S2.1)"
     Region          336..383
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S2.1)"
     Region          395..414
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S2.1)"
     CDS             1..414
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001420354.1:544..1788"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mlfhslsgpe vhgvidemdr rakseapais saidrgdtet tmpsissdra alcagcggki
       61 sdryyllavd kqwhmrclkc cecklnlese ltcfskdgsi yckedyysps lhgphrrfsv
      121 qrcarchlgi sasemvmrar dlvyhlncft cttcnkmltt gdhfgmkdsl vycrlhfeal
      181 lqgeypahfn hadvaaaaaa aaaaksaglg saganplglp yyngvgtvqk grprkrkspg
      241 pgadlaayna alscnendae hldrdqpyps sqktkrmrts fkhhqlrtmk syfainhnpd
      301 akdlkqlaqk tgltkrvlqv wfqnarakfr rnllrqentg vdktsdatlq tgtpsgpase
      361 lsnaslspss tpttltdlts ptlptvtsvl tsvpgnlegh ephspsqttl tnlf
//
LOCUS       NP_034623                537 aa            linear   ROD 27-AUG-2025
DEFINITION  intercellular adhesion molecule 1 precursor [Mus musculus].
ACCESSION   NP_034623
VERSION     NP_034623.1
DBSOURCE    REFSEQ: accession NM_010493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 537)
  AUTHORS   Deobald,K.N., Steele,S.P., Dominguez,S.R., Whiles,S. and Kawula,T.
  TITLE     Merocytophagy is an integrin-stabilized macrophage response to
            microbes reliant on Syk signaling
  JOURNAL   Front Immunol 16, 1565250 (2025)
   PUBMED   40313956
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 537)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell 60 (6), 819-836 (2025)
   PUBMED   39667932
REFERENCE   3  (residues 1 to 537)
  AUTHORS   Zhang,F., Pan,L., Lian,C., Xu,Z., Chen,H., Lai,W., Liang,X.,
            Liu,Q., Wu,H., Wang,Y., Zhang,P., Zhang,G. and Liu,Z.
  TITLE     ICAM-1 may promote the loss of dopaminergic neurons by regulating
            inflammation in MPTP-induced Parkinson's disease mouse models
  JOURNAL   Brain Res Bull 214, 110989 (2024)
   PUBMED   38825252
  REMARK    GeneRIF: ICAM-1 may promote the loss of dopaminergic neurons by
            regulating inflammation in MPTP-induced Parkinson's disease mouse
            models.
REFERENCE   4  (residues 1 to 537)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   5  (residues 1 to 537)
  AUTHORS   Ballantyne,C.M., Sligh,J.E. Jr., Dai,X.Y. and Beaudet,A.L.
  TITLE     Characterization of the murine Icam-1 gene
  JOURNAL   Genomics 14 (4), 1076-1080 (1992)
   PUBMED   1362180
REFERENCE   6  (residues 1 to 537)
  AUTHORS   Prieto,J., Kaaya,E.E., Juntti-Berggren,L., Berggren,P.O.,
            Sandler,S., Biberfeld,P. and Patarroyo,M.
  TITLE     Induction of intercellular adhesion molecule-1 (CD54) on isolated
            mouse pancreatic beta cells by inflammatory cytokines
  JOURNAL   Clin Immunol Immunopathol 65 (3), 247-253 (1992)
   PUBMED   1360342
REFERENCE   7  (residues 1 to 537)
  AUTHORS   Harning,R., Pelletier,J., Van,G., Takei,F. and Merluzzi,V.J.
  TITLE     Monoclonal antibody to MALA-2 (ICAM-1) reduces acute autoimmune
            nephritis in kdkd mice
  JOURNAL   Clin Immunol Immunopathol 64 (2), 129-134 (1992)
   PUBMED   1353711
REFERENCE   8  (residues 1 to 537)
  AUTHORS   Siu,G., Hedrick,S.M. and Brian,A.A.
  TITLE     Isolation of the murine intercellular adhesion molecule 1 (ICAM-1)
            gene. ICAM-1 enhances antigen-specific T cell activation
  JOURNAL   J Immunol 143 (11), 3813-3820 (1989)
   PUBMED   2479693
REFERENCE   9  (residues 1 to 537)
  AUTHORS   Horley,K.J., Carpenito,C., Baker,B. and Takei,F.
  TITLE     Molecular cloning of murine intercellular adhesion molecule
            (ICAM-1)
  JOURNAL   EMBO J 8 (10), 2889-2896 (1989)
   PUBMED   2573511
REFERENCE   10 (residues 1 to 537)
  AUTHORS   Ballantyne,C.M., O'Brien,W.E. and Beaudet,A.L.
  TITLE     Nucleotide sequence of the cDNA for murine intercellular adhesion
            molecule-1 (ICAM-1)
  JOURNAL   Nucleic Acids Res 17 (14), 5853 (1989)
   PUBMED   2762164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY777078.1, AK151681.1 and
            AW491621.1.
            
            Summary: This gene encodes an integral membrane protein that binds
            leukocyte adhesion protein LFA-1. It participates in the innate
            immune response. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008626.1, AK152155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.69 cM"
     Protein         1..537
                     /product="intercellular adhesion molecule 1 precursor"
                     /note="myD10"
                     /calculated_mol_wt=56160
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2702
     mat_peptide     28..537
                     /product="Intercellular adhesion molecule 1.
                     /id=PRO_0000014785"
                     /note="propagated from UniProtKB/Swiss-Prot (P13597.1)"
                     /calculated_mol_wt=56160
     Region          28..109
                     /region_name="IgI_N_ICAM-1"
                     /note="N-terminal immunoglobulin domain of the
                     intercellular adhesion molecules ICAM-1 (Cluster of
                     Differentiation 54 or CD54); member of the I-set of IgSF
                     domains; cd20996"
                     /db_xref="CDD:409588"
     Region          29..32
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409588"
     Region          35..38
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409588"
     Region          43..49
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409588"
     Site            47
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          56..61
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409588"
     Region          63..64
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409588"
     Region          66..72
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409588"
     Region          75..80
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409588"
     Region          86..94
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409588"
     Region          98..108
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409588"
     Region          111..209
                     /region_name="IgC2_2_ICAM-1_like"
                     /note="Second immunoglobulin (Ig)-like C2-set domain of
                     intercellular cell adhesion molecule 1 (ICAM-1), and
                     similar domains; cd05755"
                     /db_xref="CDD:409413"
     Region          111..118
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409413"
     Region          129..138
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409413"
     Region          145..151
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409413"
     Region          151..153
                     /region_name="Cell attachment site, atypical.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P13597.1)"
     Region          153..156
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409413"
     Region          169..176
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409413"
     Region          179..181
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P13597.1)"
     Region          184..191
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409413"
     Site            185
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748,
                     ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          200..207
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409413"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748,
                     ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          314..395
                     /region_name="Ig_2"
                     /note="Immunoglobulin domain; pfam13895"
                     /db_xref="CDD:464026"
     Site            362
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748,
                     ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Site            388
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748,
                     ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          408..478
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Site            409
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748,
                     ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          418..422
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409570"
     Region          431..435
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409570"
     Region          440..448
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409570"
     Site            456
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          458..463
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409570"
     Site            469
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Site            469
                     /site_type="other"
                     /note="Not glycosylated.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Region          471..474
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409570"
     Site            485
                     /site_type="other"
                     /note="Not glycosylated.
                     /evidence=ECO:0000269|PubMed:16877748; propagated from
                     UniProtKB/Swiss-Prot (P13597.1)"
     Site            486..509
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P13597.1)"
     CDS             1..537
                     /gene="Icam1"
                     /gene_synonym="CD54; Icam-1; Ly-47; MALA-2"
                     /coded_by="NM_010493.3:96..1709"
                     /db_xref="CCDS:CCDS22889.1"
                     /db_xref="GeneID:15894"
                     /db_xref="MGI:MGI:96392"
ORIGIN      
        1 mastrakptl plllalvtvv ipgpgdaqvs ihpreaflpq ggsvqvncss sckedlslgl
       61 etqwlkdele sgpnwklfel seigedsspl cfencgtvqs sasatitvys fpesvelrpl
      121 pawqqvgkdl tlrchvdgga prtqlsavll rgeeilsrqp vgghpkdpke itftvlasrg
      181 dhganfscrt eldlrpqgla lfsnvsears lrtfdlpati pkldtpdlle vgtqqklfcs
      241 leglfpasea riylelggqm ptqestnssd svsatalvev teefdrtlpl rcvleladqi
      301 letqrtltvy nfsapvltls qlevsegsqv tvkceahsgs kvvllsgvep rpptpqvqft
      361 lnassedhkr sffcsaalev agkflfknqt lelhvlygpr ldetdclgnw twqegsqqtl
      421 kcqawgnpsp kmtcrrkadg allpigvvks vkqemngtyv chafsshgnv trnvyltvly
      481 hsqnnwtiii lvpvllvivg lvmaasyvyn rqrkiriykl qkaqeeaikl kgqappp
//
LOCUS       NP_032239                216 aa            linear   ROD 27-AUG-2025
DEFINITION  heart- and neural crest derivatives-expressed protein 1 [Mus
            musculus].
ACCESSION   NP_032239
VERSION     NP_032239.1
DBSOURCE    REFSEQ: accession NM_008213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 216)
  AUTHORS   Cai,J.X., Le,A.W., Han,X.Y., Chen,J., Lei,X.H., Huang,C. and
            Zhang,J.V.
  TITLE     Chemerin sustains the growth of spongiotrophoblast and sinusoidal
            trophoblast giant cells through fatty acid oxidation
  JOURNAL   BMC Biol 23 (1), 199 (2025)
   PUBMED   40611253
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 216)
  AUTHORS   Abukar,S., Embacher,P.A., Ciccarelli,A., Varsani-Brown,S.,
            North,I.G.W., Dean,J.A., Briscoe,J. and Ivanovitch,K.
  TITLE     Early coordination of cell migration and cardiac fate determination
            during mammalian gastrulation
  JOURNAL   EMBO J 44 (12), 3327-3359 (2025)
   PUBMED   40360834
REFERENCE   3  (residues 1 to 216)
  AUTHORS   Menezes,N.A., Peterson,K.J., Guo,X., Castiglioni,V., Kalvisa,A.,
            Filimonow,K., Schachter,K., Schuh,C.M., Pasias,A., Mariani,L.,
            Brickman,J.M., Sedzinski,J. and Ferretti,E.
  TITLE     Cell-context response to germ layer differentiation signals is
            predetermined by the epigenome in regionalized epiblast populations
  JOURNAL   Nat Commun 16 (1), 5000 (2025)
   PUBMED   40442089
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 216)
  AUTHORS   Abraham,E., Kostina,A., Volmert,B., Roule,T., Huang,L., Yu,J.,
            Williams,A.E., Megill,E., Douglas,A., Pericak,O.M., Morris,A.,
            Stronati,E., Larrinaga-Zamanillo,A., Fueyo,R., Zubillaga,M.,
            Andrake,M.D., Akizu,N., Aguirre,A. and Estaras,C.
  TITLE     A retinoic acid:YAP1 signaling axis controls atrial lineage
            commitment
  JOURNAL   Cell Rep 44 (5), 115687 (2025)
   PUBMED   40343798
REFERENCE   5  (residues 1 to 216)
  AUTHORS   Hadas,R., Rubinstein,H., Mittnenzweig,M., Mayshar,Y., Ben-Yair,R.,
            Cheng,S., Aguilera-Castrejon,A., Reines,N., Orenbuch,A.H.,
            Lifshitz,A., Chen,D.Y., Elowitz,M.B., Zernicka-Goetz,M.,
            Hanna,J.H., Tanay,A. and Stelzer,Y.
  TITLE     Temporal BMP4 effects on mouse embryonic and extraembryonic
            development
  JOURNAL   Nature 634 (8034), 652-661 (2024)
   PUBMED   39294373
REFERENCE   6  (residues 1 to 216)
  AUTHORS   Srivastava,D., Cserjesi,P. and Olson,E.N.
  TITLE     A subclass of bHLH proteins required for cardiac morphogenesis
  JOURNAL   Science 270 (5244), 1995-1999 (1995)
   PUBMED   8533092
REFERENCE   7  (residues 1 to 216)
  AUTHORS   Cross,J.C., Flannery,M.L., Blanar,M.A., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Rutter,W.J. and Werb,Z.
  TITLE     Hxt encodes a basic helix-loop-helix transcription factor that
            regulates trophoblast cell development
  JOURNAL   Development 121 (8), 2513-2523 (1995)
   PUBMED   7671815
REFERENCE   8  (residues 1 to 216)
  AUTHORS   Cserjesi,P., Brown,D., Lyons,G.E. and Olson,E.N.
  TITLE     Expression of the novel basic helix-loop-helix gene eHAND in neural
            crest derivatives and extraembryonic membranes during mouse
            development
  JOURNAL   Dev Biol 170 (2), 664-678 (1995)
   PUBMED   7649392
REFERENCE   9  (residues 1 to 216)
  AUTHORS   Hollenberg,S.M., Sternglanz,R., Cheng,P.F. and Weintraub,H.
  TITLE     Identification of a new family of tissue-specific basic
            helix-loop-helix proteins with a two-hybrid system
  JOURNAL   Mol Cell Biol 15 (7), 3813-3822 (1995)
   PUBMED   7791788
REFERENCE   10 (residues 1 to 216)
  AUTHORS   Oude Elferink,R.P., Ottenhoff,R., van Wijland,M., Smit,J.J.,
            Schinkel,A.H. and Groen,A.K.
  TITLE     Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the
            mouse
  JOURNAL   J Clin Invest 95 (1), 31-38 (1995)
   PUBMED   7814632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732587.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21226.1, BC050182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.27 cM"
     Protein         1..216
                     /product="heart- and neural crest derivatives-expressed
                     protein 1"
                     /note="thing-1; heart and neural crest derivatives
                     expressed transcript 1; helix-loop-helix transcription
                     factor expressed in extraembryonic mesoderm and
                     trophoblast; extraembryonic tissues, heart, autonomic
                     nervous system and neural crest derivatives-expressed
                     protein 1"
                     /calculated_mol_wt=23675
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64279.1)"
     Region          53..109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64279.1)"
     Region          94..153
                     /region_name="bHLH_TS_HAND1"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     heart- and neural crest derivatives-expressed protein 1
                     (HAND1) and similar proteins; cd18952"
                     /db_xref="CDD:381522"
     Site            order(96,100,102..104,106,111,129..132)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381522"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PLK4.
                     /evidence=ECO:0000269|PubMed:17891141; propagated from
                     UniProtKB/Swiss-Prot (Q64279.1)"
     Site            order(109..110,113..114,116..117,133,136,140,142..143,147,
                     149..150)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381522"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK4.
                     /evidence=ECO:0000269|PubMed:17891141; propagated from
                     UniProtKB/Swiss-Prot (Q64279.1)"
     Region          165..203
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64279.1)"
     CDS             1..216
                     /gene="Hand1"
                     /gene_synonym="bHLHa27; eHAND; Ehand1; Hxt; Th1; Thing1"
                     /coded_by="NM_008213.2:362..1012"
                     /db_xref="CCDS:CCDS24721.1"
                     /db_xref="GeneID:15110"
                     /db_xref="MGI:MGI:103577"
ORIGIN      
        1 mnlvgsyahh hhhhhshpph pmlhepflfg pasrchqerp yfqswllspa daapdfpagg
       61 pppttavaaa aygpdarpsq spgrlealgs rlpkrkgsgp kkerrrtesi nsafaelrec
      121 ipnvpadtkl skiktlrlat syiaylmdvl akdaqagdpe afkaelkktd ggreskrkre
      181 lpqqpesfpp asgpgekrik grtgwpqqvw alelnq
//
LOCUS       NP_032683                242 aa            linear   ROD 27-AUG-2025
DEFINITION  myogenic factor 6 [Mus musculus].
ACCESSION   NP_032683
VERSION     NP_032683.1
DBSOURCE    REFSEQ: accession NM_008657.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 242)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 242)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   3  (residues 1 to 242)
  AUTHORS   Tekko,T., Lozovska,A., Novoa,A. and Mallo,M.
  TITLE     Assessing Myf5 and Lbx1 contribution to carapace development by
            reproducing their turtle-specific signatures in mouse embryos
  JOURNAL   Dev Dyn 251 (10), 1698-1710 (2022)
   PUBMED   35618666
REFERENCE   4  (residues 1 to 242)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 242)
  AUTHORS   Zhu,Q., Liang,F., Cai,S., Luo,X., Duo,T., Liang,Z., He,Z., Chen,Y.
            and Mo,D.
  TITLE     KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic
            regulatory factors
  JOURNAL   Cell Death Dis 12 (6), 514 (2021)
   PUBMED   34011940
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 242)
  AUTHORS   Braun,T., Rudnicki,M.A., Arnold,H.H. and Jaenisch,R.
  TITLE     Targeted inactivation of the muscle regulatory gene Myf-5 results
            in abnormal rib development and perinatal death
  JOURNAL   Cell 71 (3), 369-382 (1992)
   PUBMED   1423602
REFERENCE   7  (residues 1 to 242)
  AUTHORS   Block,N.E. and Miller,J.B.
  TITLE     Expression of MRF4, a myogenic helix-loop-helix protein, produces
            multiple changes in the myogenic program of BC3H-1 cells
  JOURNAL   Mol Cell Biol 12 (6), 2484-2492 (1992)
   PUBMED   1588952
REFERENCE   8  (residues 1 to 242)
  AUTHORS   Hannon,K., Smith,C.K. 2nd, Bales,K.R. and Santerre,R.F.
  TITLE     Temporal and quantitative analysis of myogenic regulatory and
            growth factor gene expression in the developing mouse embryo
  JOURNAL   Dev Biol 151 (1), 137-144 (1992)
   PUBMED   1374351
REFERENCE   9  (residues 1 to 242)
  AUTHORS   Hinterberger,T.J., Sassoon,D.A., Rhodes,S.J. and Konieczny,S.F.
  TITLE     Expression of the muscle regulatory factor MRF4 during somite and
            skeletal myofiber development
  JOURNAL   Dev Biol 147 (1), 144-156 (1991)
   PUBMED   1715299
REFERENCE   10 (residues 1 to 242)
  AUTHORS   Weintraub,H., Davis,R., Tapscott,S., Thayer,M., Krause,M.,
            Benezra,R., Blackwell,T.K., Turner,D., Rupp,R., Hollenberg,S. et
            al.
  TITLE     The myoD gene family: nodal point during specification of the
            muscle cell lineage
  JOURNAL   Science 251 (4995), 761-766 (1991)
   PUBMED   1846704
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155168.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59060.1, AK029370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 55.96 cM"
     Protein         1..242
                     /product="myogenic factor 6"
                     /note="muscle-specific regulatory factor 4"
                     /calculated_mol_wt=26855
     Region          3..98
                     /region_name="Basic"
                     /note="Myogenic Basic domain; cl11603"
                     /db_xref="CDD:472231"
     Region          31..63
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15375.1)"
     Region          93..156
                     /region_name="bHLH_TS_MRF4_Myf6"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     muscle-specific regulatory factor 4 (MRF4) and similar
                     proteins; cd18934"
                     /db_xref="CDD:381504"
     Site            order(94..95,99,101..103,105,110,127..130)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381504"
     Site            order(108..109,112..113,115..116,131,134,138,140..141,145,
                     147..148)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381504"
     CDS             1..242
                     /gene="Myf6"
                     /gene_synonym="bHLHc4; herculin; MRF4"
                     /coded_by="NM_008657.3:20..748"
                     /db_xref="CCDS:CCDS24162.1"
                     /db_xref="GeneID:17878"
                     /db_xref="MGI:MGI:97253"
ORIGIN      
        1 mmmdlfetgs yffyldgenv tlqplevaeg splypgsdgt lspcqdqmpq eagsdssgee
       61 hvlappglqp phcpgqcliw acktckrksa ptdrrkaatl rerrrlkkin eafealkrrt
      121 vanpnqrlpk veilrsaisy ierlqdllhr ldqqekmqel gvdpysykpk qeilegadfl
      181 rtcspqwpsv sdhsrglvit akegganvda sassslqrls sivdsissee rklpsveevv
      241 ek
//
LOCUS       NP_001396831             147 aa            linear   ROD 27-AUG-2025
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001396831
VERSION     NP_001396831.1
DBSOURCE    REFSEQ: accession NM_001409902.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Demenego,G., Mancinelli,S., Borreca,A., Proce,R.O., Aragona,V.,
            Miotto,M., Cremonesi,M., Zucchelli,L., Corradini,I., Kim,E.,
            Ilic,K., Fraviga,E., Pellegrino,L., Badolato,R., Rusconi,R.,
            Pozzi,D., Kallikourdis,M., Cash,D., Matteoli,M. and Lodato,S.
  TITLE     Neurodevelopmental origins of structural and psychomotor defects in
            CXCR4-linked primary immunodeficiency
  JOURNAL   Neuron 113 (16), 2636-2655 (2025)
   PUBMED   40482638
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Hohsfield,L.A., Kim,S.J., Barahona,R.A., Henningfield,C.M.,
            Mansour,K., Vallejo,K.D., Tsourmas,K.I., Kwang,N.E., Ghorbanian,Y.,
            Angulo,J.A.A., Gao,P., Pachow,C., Inlay,M.A., Walsh,C.M., Xu,X.,
            Lane,T.E. and Green,K.N.
  TITLE     Identification of the velum interpositum as a meningeal-CNS route
            for myeloid cell trafficking into the brain
  JOURNAL   Neuron 113 (15), 2455-2473 (2025)
   PUBMED   40466634
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Guo,M., Liu,L., Mao,X., Xiao,M., He,X., Pan,X., Chen,Y., Yi,W.,
            Li,Q., Piao,X., Wang,H., Du,Y. and Cheng,Y.
  TITLE     Deciphering the role of CAPZA2 in neurodevelopmental disorders:
            insights from mouse models
  JOURNAL   Commun Biol 8 (1), 1048 (2025)
   PUBMED   40659881
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki,Y., Ohsawa,K., Kanazawa,H., Kohsaka,S. and Imai,Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa,K., Imai,Y., Kanazawa,H., Sasaki,Y. and Kohsaka,S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund,T., Shaikh,S., Kendall,E., Campbell,R.D., Hattori,M.,
            Makino,S. and Cooke,A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021539.1, BI685218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001409902.1:91..534"
                     /note="isoform a is encoded by transcript variant 5"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_001408096             370 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform t [Mus musculus].
ACCESSION   NP_001408096 XP_030109113
VERSION     NP_001408096.1
DBSOURCE    REFSEQ: accession NM_001421167.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 370)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 370)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 370)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 370)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 370)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 370)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 370)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 370)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 370)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 370)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_030109113.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3540180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..370
                     /product="ELAV-like protein 4 isoform t"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=40529
     Region          46..369
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..370
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421167.1:117..1229"
                     /note="isoform t is encoded by transcript variant 23"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mrlqnqiist mepqvsngpt sntsngpssn nrncpspmqt gaatddsktn livnylpqnm
       61 tqeefrslfg sigeiesckl vrdkitgqsl gygfvnyidp kdaekaintl nglrlqtkti
      121 kvsyarpssa sirdanlyvs glpktmtqke leqlfsqygr iitsrilvdq vtgvsrgvgf
      181 irfdkrieae eaikglngqk psgatepitv kfannpsqks sqallsqlyq spnrrypgpl
      241 hhqaqrfrlm sgpvppsacp prfspitidg mtslvgmnip ghtgtgwcif vynlspdsde
      301 svlwqlfgpf gavnnvkvir dfntnkckgf gfvtmtnyde aamaiaslng yrlgdrvlqv
      361 sfktnkahks
//
LOCUS       NP_035773                793 aa            linear   ROD 27-AUG-2025
DEFINITION  short transient receptor potential channel 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_035773
VERSION     NP_035773.2
DBSOURCE    REFSEQ: accession NM_011643.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 793)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 793)
  AUTHORS   Ray,S., McCall,J.L., Tian,J.B., Jeon,J., Douglas,A., Tyler,K.,
            Liu,S., Berry,K., Nicewarner,B., Hall,C., Groschner,K., Bacsa,B.,
            Geldenhuys,W., Zhu,M.X., Blair,H.C., Barnett,J.B. and Soboloff,J.
  TITLE     Targeting TRPC channels for control of arthritis-induced bone
            erosion
  JOURNAL   Sci Adv 11 (3), eabm9843 (2025)
   PUBMED   39813349
REFERENCE   3  (residues 1 to 793)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   4  (residues 1 to 793)
  AUTHORS   Atkins,R.M., Pantalia,M., Skaggs,C., Lau,A.K., Mahmood,M.B.,
            Anwar,M.M., Barron,L., Eby,B., Khan,U., Tsiokas,L. and Lau,K.
  TITLE     Normotensive metabolic syndrome in Transient Receptor Potential
            Canonical Channel type 1 Trpc1-/- mice
  JOURNAL   Biol Open 13 (7) (2024)
   PUBMED   38885005
  REMARK    GeneRIF: Normotensive metabolic syndrome in Transient Receptor
            Potential Canonical Channel type 1 Trpc1-/- mice.
REFERENCE   5  (residues 1 to 793)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 793)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
REFERENCE   7  (residues 1 to 793)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (residues 1 to 793)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (residues 1 to 793)
  AUTHORS   Sakura,H. and Ashcroft,F.M.
  TITLE     Identification of four trp1 gene variants murine pancreatic
            beta-cells
  JOURNAL   Diabetologia 40 (5), 528-532 (1997)
   PUBMED   9165220
REFERENCE   10 (residues 1 to 793)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC157947.2.
            
            On May 14, 2019 this sequence version replaced NP_035773.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137581.1, U73625.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.2 cM"
     Protein         1..793
                     /product="short transient receptor potential channel 1
                     isoform 1"
                     /note="short transient receptor potential channel 1;
                     trp-related protein 1; transient receptor protein 1"
                     /calculated_mol_wt=91082
     Region          1..30
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Region          46..75
                     /region_name="ANK 1.
                     /evidence=ECO:0000250|UniProtKB:P48995"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Region          48..774
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     Region          83..109
                     /region_name="ANK 2.
                     /evidence=ECO:0000250|UniProtKB:P48995"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Region          111..156
                     /region_name="ANK 3.
                     /evidence=ECO:0000250|UniProtKB:P48995"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Region          158..180
                     /region_name="ANK 4.
                     /evidence=ECO:0000250|UniProtKB:P48995"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            387..404
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            423..439
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            456..475
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            497..517
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            537..558
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     Site            624..644
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61056.5)"
     CDS             1..793
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /coded_by="NM_011643.4:510..2891"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23411.1"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
ORIGIN      
        1 mmaalypstd lsgvsssslp sspsssspne vmalkdvrev keentlnekl fllacdkgdy
       61 ymvkkileen ssgdlnincv dvlgrnavti tienesldil qllldygcqs adallvaids
      121 evvgavdill nhrpkrssrp tivklmeriq npeysttmdv apvilaahrn nyeiltmllk
      181 qdvslpkpha vgcectlcsa knkkdslrhs rfrldiyrcl aspalimlte edpilrafel
      241 sadlkelslv evefrndyee larqckmfak dllaqarnsr elevilnhts sdepldkrgl
      301 leermnlsrl klaikynqke fvsqsncqqf lntvwfgqms gyrrkptckk imtvltvgif
      361 wpvlslcyli apksqfgrii htpfmkfiih gasyftflll lnlyslvyne dkkntmgpal
      421 eridyllilw iigmiwsdik rlwyegledf leesrnqlsf vmnslylatf alkvvahnkf
      481 hdfadrkdwd afhptlvaeg lfafanvlsy lrlffmytts silgplqism gqmlqdfgkf
      541 lgmfllvlfs ftigltqlyd kgytskeqkd cvgifceqqs ndtfhsfigt cfalfwyifs
      601 lahvaifvtr fsygeelqsf vgavivgtyn vvvvivltkl lvamlhksfq lianhedkew
      661 kfaraklwls yfddkctlpp pfniipspkt icymisslsk wicshtskgk vkrqnslkew
      721 rnlkqkrden yqkvmcclvh ryltsmrqkm qstdqatven lnelrqdlsk frneirdllg
      781 frtskyamfy prn
//
LOCUS       NP_001171258             464 aa            linear   ROD 27-AUG-2025
DEFINITION  CD44 antigen isoform f precursor [Mus musculus].
ACCESSION   NP_001171258
VERSION     NP_001171258.1
DBSOURCE    REFSEQ: accession NM_001177787.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Guo,J., Zheng,J., Li,R., Yao,J., Zhang,H., Wang,X. and Zhang,C.
  TITLE     Single-cell transcriptome analysis reveals abnormal angiogenesis
            and placentation by loss of imprinted glutaminyl-peptide
            cyclotransferase
  JOURNAL   J Zhejiang Univ Sci B 26 (6), 589-608 (2025)
   PUBMED   40571662
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Deobald,K.N., Steele,S.P., Dominguez,S.R., Whiles,S. and Kawula,T.
  TITLE     Merocytophagy is an integrin-stabilized macrophage response to
            microbes reliant on Syk signaling
  JOURNAL   Front Immunol 16, 1565250 (2025)
   PUBMED   40313956
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Zhang,C., Huang,Q., Ford,N.C., Limjunyawong,N., Lin,Q., Yang,F.,
            Cui,X., Uniyal,A., Liu,J., Mahabole,M., He,H., Wang,X., Duff,I.,
            Wang,Y., Wan,J., Zhu,G., Raja,S.N., Jia,H., Yang,D., Dong,X.,
            Cao,X., Tseng,S.C., He,S. and Guan,Y.
  TITLE     Human birth tissue products as a non-opioid medicine to inhibit
            post-surgical pain
  JOURNAL   Elife 13, 101269 (2024)
   PUBMED   39671234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 464)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Araujo David,B., Atif,J., Vargas E Silva Castanheira,F., Yasmin,T.,
            Guillot,A., Ait Ahmed,Y., Peiseler,M., Hommes,J.W., Salm,L.,
            Brundler,M.A., Surewaard,B.G.J., Elhenawy,W., MacParland,S.,
            Ginhoux,F., McCoy,K. and Kubes,P.
  TITLE     Kupffer cell reverse migration into the liver sinusoids mitigates
            neonatal sepsis and meningitis
  JOURNAL   Sci Immunol 9 (101), eadq9704 (2024)
   PUBMED   39485859
REFERENCE   6  (residues 1 to 464)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Moen,C.J., Snoek,M., Hart,A.A. and Demant,P.
  TITLE     Scc-1, a novel colon cancer susceptibility gene in the mouse:
            linkage to CD44 (Ly-24, Pgp-1) on chromosome 2
  JOURNAL   Oncogene 7 (3), 563-566 (1992)
   PUBMED   1347918
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Fleischman,R.A. and Mintz,B.
  TITLE     Prevention of genetic anemias in mice by microinjection of normal
            hematopoietic stem cells into the fetal placenta
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5736-5740 (1979)
   PUBMED   42904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844155.6, AK045226.1 and AJ251594.1.
            
            Transcript Variant: This variant (5) lacks several alternate,
            in-frame, exons, compared to variant 1. The resulting protein
            (isoform f) is shorter when it is compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66081.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     Protein         1..464
                     /product="CD44 antigen isoform f precursor"
                     /note="PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; lymphocyte antigen 24; phagocytic
                     glycoprotein 1; extracellular matrix receptor III; GP90
                     lymphocyte homing/adhesion receptor; phagocytic
                     glycoprotein I"
                     /calculated_mol_wt=48306
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2420
     Region          30..173
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(42,45..46,72,82..83,104..105,109)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     CDS             1..464
                     /gene="Cd44"
                     /gene_synonym="HERMES; Ly-24; Pgp-1"
                     /coded_by="NM_001177787.1:320..1714"
                     /note="isoform f precursor is encoded by transcript
                     variant 6"
                     /db_xref="CCDS:CCDS50648.1"
                     /db_xref="GeneID:12505"
                     /db_xref="MGI:MGI:88338"
ORIGIN      
        1 mdkfwwhtaw glcllqlsla hphqqidlnv tcryagvfhv ekngrysisr teaadlcqaf
       61 nstlptmdqm klalskgfet crygfiegnv viprihpnai caanhtgvyi lvtsntshyd
      121 tycfnasapp eedctsvtdl pnsfdgpvti tivnrdgtry skkgeyrthq edidasniid
      181 ddvssgstie kstpesyilh tylpteqptg dqddsffirs tlattqshsq nfstlhgepe
      241 edenhpttsi lpsstksgak darrggslpt dtttsvegyt fqypdtmeng tlfpvtpakt
      301 evfgetevtl atdsnvnvdg slpgdrdssk dsrgssrtvt hgselaghss anqdsgvttt
      361 sgpmrrpqip ewliilasll alalilavci avnsrrrcgq kkklvinggn gtvedrkpse
      421 lngeasksqe mvhlvnkeps etpdqcmtad etrnlqsvdm kigv
//
LOCUS       NP_001159835             204 aa            linear   ROD 27-AUG-2025
DEFINITION  fibroblast growth factor 8 isoform 4 precursor [Mus musculus].
ACCESSION   NP_001159835
VERSION     NP_001159835.1
DBSOURCE    REFSEQ: accession NM_001166363.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 204)
  AUTHORS   Zhang,Z., Yu,Z., Chong,Y., Liu,Y., Liu,J., Ren,W., Xu,S. and
            Yang,G.
  TITLE     Evolution of cetacean-specific conserved non-coding elements
            suggests their role in the limb changes during secondary aquatic
            adaptation
  JOURNAL   BMC Biol 23 (1), 216 (2025)
   PUBMED   40670992
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 204)
  AUTHORS   Glaser,J., Cova,G., Fauler,B., Prada-Medina,C.A., Stanislas,V.,
            Phan,M.H.Q., Schopflin,R., Aktas,Y., Franke,M., Andrey,G.,
            Bartzoka,N., Paliou,C., Laupert,V., Chan,W.L., Wittler,L.,
            Mielke,T. and Mundlos,S.
  TITLE     Enhancer adoption by an LTR retrotransposon generates viral-like
            particles, causing developmental limb phenotypes
  JOURNAL   Nat Genet 57 (7), 1766-1776 (2025)
   PUBMED   40634706
REFERENCE   3  (residues 1 to 204)
  AUTHORS   Wu,S., Bian,Y., Zhang,C., Liu,K., Sun,F., Chen,E., Zhou,C., Yu,L.,
            Chen,G. and Wu,M.
  TITLE     Merlin controls limb development and thumb formation by regulating
            primary cilium-hedgehog signaling
  JOURNAL   Cell Rep 44 (6), 115849 (2025)
   PUBMED   40503937
REFERENCE   4  (residues 1 to 204)
  AUTHORS   Huang,Y., Tsang,S.W., Tsang,W.H. and Chow,K.L.
  TITLE     Mab21l2 is required to promote cell proliferation in stylopods
            during early limb development
  JOURNAL   Biochem Biophys Res Commun 756, 151534 (2025)
   PUBMED   40054064
  REMARK    Erratum:[Biochem Biophys Res Commun. 2025 May 26;760:151679. doi:
            10.1016/j.bbrc.2025.151679. PMID: 40157810]
REFERENCE   5  (residues 1 to 204)
  AUTHORS   Wang,S. and Zheng,Z.
  TITLE     Differences in Formation of Prepuce and Urethral Groove During
            Penile Development Between Guinea Pigs and Mice Are Controlled by
            Differential Expression of Shh, Fgf10 and Fgfr2
  JOURNAL   Cells 14 (5), 348 (2025)
   PUBMED   40072077
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 204)
  AUTHORS   Chan,D.C., Wynshaw-Boris,A. and Leder,P.
  TITLE     Formin isoforms are differentially expressed in the mouse embryo
            and are required for normal expression of fgf-4 and shh in the limb
            bud
  JOURNAL   Development 121 (10), 3151-3162 (1995)
   PUBMED   7588050
REFERENCE   7  (residues 1 to 204)
  AUTHORS   Mahmood,R., Bresnick,J., Hornbruch,A., Mahony,C., Morton,N.,
            Colquhoun,K., Martin,P., Lumsden,A., Dickson,C. and Mason,I.
  TITLE     A role for FGF-8 in the initiation and maintenance of vertebrate
            limb bud outgrowth
  JOURNAL   Curr Biol 5 (7), 797-806 (1995)
   PUBMED   7583127
REFERENCE   8  (residues 1 to 204)
  AUTHORS   Tanaka,A., Miyamoto,K., Matsuo,H., Matsumoto,K. and Yoshida,H.
  TITLE     Human androgen-induced growth factor in prostate and breast cancer
            cells: its molecular cloning and growth properties
  JOURNAL   FEBS Lett 363 (3), 226-230 (1995)
   PUBMED   7737407
REFERENCE   9  (residues 1 to 204)
  AUTHORS   Mattei,M.G., deLapeyriere,O., Bresnick,J., Dickson,C., Birnbaum,D.
            and Mason,I.
  TITLE     Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth
            factor 8) genes map to chromosomes 2 and 19 respectively
  JOURNAL   Mamm Genome 6 (3), 196-197 (1995)
   PUBMED   7749227
REFERENCE   10 (residues 1 to 204)
  AUTHORS   Tanaka,A., Miyamoto,K., Minamino,N., Takeda,M., Sato,B., Matsuo,H.
            and Matsumoto,K.
  TITLE     Cloning and characterization of an androgen-induced growth factor
            essential for the androgen-dependent growth of mouse mammary
            carcinoma cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8928-8932 (1992)
   PUBMED   1409588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149086.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U18673.1, Z48746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.75 cM"
     Protein         1..204
                     /product="fibroblast growth factor 8 isoform 4 precursor"
                     /note="androgen-induced growth factor; heparin-binding
                     growth factor 8; fibroblast growth factor 6c"
                     /calculated_mol_wt=21201
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2339
     Region          23..167
                     /region_name="beta-trefoil_FGF8"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 8 (FGF8) and similar proteins; cd23322"
                     /db_xref="CDD:467008"
     Site            23
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P37237.1)"
     Site            order(24..25,28,33,35..37,39..41,46,48,51,53,77..79,
                     81..84,86,120,122..124,126..128,144,164..167)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:467008"
     CDS             1..204
                     /gene="Fgf8"
                     /gene_synonym="Aigf; Fgf-8; Fgf6c; HBGF-8"
                     /coded_by="NM_001166363.2:211..825"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS50450.1"
                     /db_xref="GeneID:14179"
                     /db_xref="MGI:MGI:99604"
ORIGIN      
        1 mgsprsalsc lllhllvlcl qaqhvreqsl vtdqlsrrli rtyqlysrts gkhvqvlank
       61 rinamaedgd pfaklivetd tfgsrvrvrg aetglyicmn kkgkliaksn gkgkdcvfte
      121 ivlennytal qnakyegwym aftrkgrprk gsktrqhqre vhfmkrlprg hhtteqslrf
      181 eflnyppftr slrgsqrtwa pepr
//
LOCUS       NP_033196                437 aa            linear   ROD 27-AUG-2025
DEFINITION  sonic hedgehog protein isoform 1 precursor [Mus musculus].
ACCESSION   NP_033196
VERSION     NP_033196.1
DBSOURCE    REFSEQ: accession NM_009170.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Nagata,M., Gadhvi,G.T., Komori,T., Arai,Y., Tsutsumi-Arai,C.,
            Chu,A.K.Y., Nye,S.N., Yang,Y., Orikasa,S., Takahashi,A.,
            Carlsson,P., Zheng,W.J., Welch,J.D., Ono,N. and Ono,W.
  TITLE     A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar
            bone formation
  JOURNAL   Nat Commun 16 (1), 6061 (2025)
   PUBMED   40593802
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Glaser,J., Cova,G., Fauler,B., Prada-Medina,C.A., Stanislas,V.,
            Phan,M.H.Q., Schopflin,R., Aktas,Y., Franke,M., Andrey,G.,
            Bartzoka,N., Paliou,C., Laupert,V., Chan,W.L., Wittler,L.,
            Mielke,T. and Mundlos,S.
  TITLE     Enhancer adoption by an LTR retrotransposon generates viral-like
            particles, causing developmental limb phenotypes
  JOURNAL   Nat Genet 57 (7), 1766-1776 (2025)
   PUBMED   40634706
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Wu,S., Bian,Y., Zhang,C., Liu,K., Sun,F., Chen,E., Zhou,C., Yu,L.,
            Chen,G. and Wu,M.
  TITLE     Merlin controls limb development and thumb formation by regulating
            primary cilium-hedgehog signaling
  JOURNAL   Cell Rep 44 (6), 115849 (2025)
   PUBMED   40503937
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Kong,W., Lu,W.J., Dubey,M., Suryawanshi,R.K., Vijayakumar,S.,
            Jeong,Y., Gombar,S., Diehn,M., Shin,K., Ott,M., Chien,Y.H.,
            Sarin,K.Y., Desai,T.J. and Beachy,P.A.
  TITLE     Neuroendocrine cells orchestrate regeneration through Desert
            hedgehog signaling
  JOURNAL   Cell (2025) In press
   PUBMED   40494346
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Cereghini,S., Ott,M.O., Power,S. and Maury,M.
  TITLE     Expression patterns of vHNF1 and HNF1 homeoproteins in early
            postimplantation embryos suggest distinct and sequential
            developmental roles
  JOURNAL   Development 116 (3), 783-797 (1992)
   PUBMED   1363228
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Martin,G.R., Richman,M., Reinsch,S., Nadeau,J.H. and Joyner,A.
  TITLE     Mapping of the two mouse engrailed-like genes: close linkage of
            En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to
            hemimelic extra-toes (Hx) on chromosome 5
  JOURNAL   Genomics 6 (2), 302-308 (1990)
   PUBMED   2307472
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Cheng,S.V., Martin,G.R., Nadeau,J.H., Haines,J.L., Bucan,M.,
            Kozak,C.A., MacDonald,M.E., Lockyer,J.L., Ledley,F.D., Woo,S.L. et
            al.
  TITLE     Synteny on mouse chromosome 5 of homologs for human DNA loci linked
            to the Huntington disease gene
  JOURNAL   Genomics 4 (3), 419-426 (1989)
   PUBMED   2523855
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Kozak,C.A., Gromet,N.J., Ikeda,H. and Buckler,C.E.
  TITLE     A unique sequence related to the ecotropic murine leukemia virus is
            associated with the Fv-4 resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 81 (3), 834-837 (1984)
   PUBMED   6322171
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Kozak,C.A. and Rowe,W.P.
  TITLE     Genetic mapping of ecotropic murine leukemia virus-inducing loci in
            six inbred strains
  JOURNAL   J Exp Med 155 (2), 524-534 (1982)
   PUBMED   6276492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134530.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063087.1, AK077688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN01164133 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 14.39 cM"
     Protein         1..437
                     /product="sonic hedgehog protein isoform 1 precursor"
                     /note="sonic hedgehog protein; hemimelic extra toes; short
                     digits; shh unprocessed N-terminal signaling and
                     C-terminal autoprocessing domains"
                     /calculated_mol_wt=45261
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2530
     mat_peptide     25..437
                     /product="Sonic hedgehog protein. /id=PRO_0000013211"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62226.2)"
                     /calculated_mol_wt=45261
     Region          25..185
                     /region_name="HH_signal"
                     /note="Hedgehog amino-terminal signalling domain;
                     pfam01085"
                     /db_xref="CDD:460055"
     Region          33..39
                     /region_name="Cardin-Weintraub.
                     /evidence=ECO:0000269|PubMed:23118222"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62226.2)"
     Region          187..423
                     /region_name="Hint"
                     /note="Hint module; pfam01079"
                     /db_xref="CDD:460051"
     Site            198..199
                     /site_type="cleavage"
                     /note="Cleavage, by autolysis.
                     /evidence=ECO:0000250|UniProtKB:Q02936; propagated from
                     UniProtKB/Swiss-Prot (Q62226.2)"
     Site            244
                     /site_type="other"
                     /note="Involved in cholesterol transfer.
                     /evidence=ECO:0000250|UniProtKB:Q02936; propagated from
                     UniProtKB/Swiss-Prot (Q62226.2)"
     Site            268
                     /site_type="other"
                     /note="Involved in auto-cleavage.
                     /evidence=ECO:0000250|UniProtKB:Q02936; propagated from
                     UniProtKB/Swiss-Prot (Q62226.2)"
     Site            271
                     /site_type="other"
                     /note="Essential for auto-cleavage.
                     /evidence=ECO:0000250|UniProtKB:Q02936; propagated from
                     UniProtKB/Swiss-Prot (Q62226.2)"
     Site            279
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q62226.2)"
     CDS             1..437
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; HHG-1; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /coded_by="NM_009170.4:339..1652"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19146.1"
                     /db_xref="GeneID:20423"
                     /db_xref="MGI:MGI:98297"
ORIGIN      
        1 mllllarcfl vilassllvc pglacgpgrg fgkrrhpkkl tplaykqfip nvaektlgas
       61 gryegkitrn serfkeltpn ynpdiifkde entgadrlmt qrckdklnal aisvmnqwpg
      121 vklrvtegwd edghhseesl hyegravdit tsdrdrskyg mlarlaveag fdwvyyeska
      181 hihcsvkaen svaaksggcf pgsatvhleq ggtklvkdlr pgdrvlaadd qgrllysdfl
      241 tfldrdegak kvfyvietle prerllltaa hllfvaphnd sgptpgpsal fasrvrpgqr
      301 vyvvaerggd rrllpaavhs vtlreeeaga yapltahgti linrvlascy avieehswah
      361 rafapfrlah allaalapar tdgggggsip aaqsatearg aeptagihwy sqllyhigtw
      421 lldsetmhpl gmavkss
//
LOCUS       NP_001277575             365 aa            linear   ROD 27-AUG-2025
DEFINITION  LIM/homeobox protein Lhx2 isoform b [Mus musculus].
ACCESSION   NP_001277575 XP_006497800
VERSION     NP_001277575.1
DBSOURCE    REFSEQ: accession NM_001290646.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 365)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 365)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 365)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 365)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            On Mar 15, 2014 this sequence version replaced XP_006497800.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and it thus differs in the 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a. Variants 2, 5, and 6 all encode the same
            isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086638.1, SRR7652917.894695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..365
                     /product="LIM/homeobox protein Lhx2 isoform b"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=39878
     Region          2..65
                     /region_name="LIM1_Lhx2"
                     /note="The first LIM domain of Lhx2; cd09469"
                     /db_xref="CDD:188853"
     Site            order(12,15,33,36,39,42,61,64)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188853"
     Region          70..128
                     /region_name="LIM2_Lhx2_Lhx9"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     cd09377"
                     /db_xref="CDD:188763"
     Site            order(74,77,96,99,102,105,124,127)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188763"
     Region          <206..337
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          226..282
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..365
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001290646.2:540..1637"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS71048.1"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mpsissdraa lcagcggkis dryyllavdk qwhmrclkcc ecklnlesel tcfskdgsiy
       61 ckedyyrrfs vqrcarchlg isasemvmra rdlvyhlncf tcttcnkmlt tgdhfgmkds
      121 lvycrlhfea llqgeypahf nhadvaaaaa aaaaaksagl gsaganplgl pyyngvgtvq
      181 kgrprkrksp gpgadlaayn aalscnenda ehldrdqpyp ssqktkrmrt sfkhhqlrtm
      241 ksyfainhnp dakdlkqlaq ktgltkrvlq vwfqnarakf rrnllrqent gvdktsdatl
      301 qtgtpsgpas elsnaslsps stpttltdlt sptlptvtsv ltsvpgnleg hephspsqtt
      361 ltnlf
//
LOCUS       NP_001386702             361 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor MafA [Rattus norvegicus].
ACCESSION   NP_001386702 XP_006241965
VERSION     NP_001386702.1
DBSOURCE    REFSEQ: accession NM_001399773.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 361)
  AUTHORS   Navik,U., Rawat,K. and Tikoo,K.
  TITLE     L-Methionine prevents beta-cell damage by modulating the expression
            of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats
  JOURNAL   Acta Histochem 124 (1), 151820 (2022)
   PUBMED   34871948
  REMARK    GeneRIF: L-Methionine prevents beta-cell damage by modulating the
            expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic
            rats.
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Lu,J., Lin,L., Dong,H., Meng,X., Fang,F., Wang,Q., Huang,L. and
            Tan,J.
  TITLE     Protein therapy using MafA fused to a polyarginine transduction
            domain attenuates glucose levels of streptozotocin-induced diabetic
            mice
  JOURNAL   Mol Med Rep 15 (6), 4041-4048 (2017)
   PUBMED   28487936
REFERENCE   3  (residues 1 to 361)
  AUTHORS   Mahadevan,J., Parazzoli,S., Oseid,E., Hertzel,A.V., Bernlohr,D.A.,
            Vallerie,S.N., Liu,C.Q., Lopez,M., Harmon,J.S. and Robertson,R.P.
  TITLE     Ebselen treatment prevents islet apoptosis, maintains intranuclear
            Pdx-1 and MafA levels, and preserves beta-cell mass and function in
            ZDF rats
  JOURNAL   Diabetes 62 (10), 3582-3588 (2013)
   PUBMED   23801580
REFERENCE   4  (residues 1 to 361)
  AUTHORS   Bonnavion,R., Jaafar,R., Kerr-Conte,J., Assade,F., van Stralen,E.,
            Leteurtre,E., Pouponnot,C., Gargani,S., Pattou,F., Bertolino,P.,
            Cordier-Bussat,M., Lu,J. and Zhang,C.X.
  TITLE     Both PAX4 and MAFA are expressed in a substantial proportion of
            normal human pancreatic alpha cells and deregulated in patients
            with type 2 diabetes
  JOURNAL   PLoS One 8 (8), e72194 (2013)
   PUBMED   24013263
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 361)
  AUTHORS   Cao,M., Long,Y., Tong,Y., Wan,J. and Tong,N.
  TITLE     Activation of PPARdelta up-regulates the expression of insulin gene
            transcription factor MafA and ameliorates glucose-induced insulin
            secretion impaired by palmitate
  JOURNAL   Mol Cell Biochem 366 (1-2), 183-189 (2012)
   PUBMED   22466807
  REMARK    GeneRIF: PPAR-gamma may regulate the expression of MafA
REFERENCE   6  (residues 1 to 361)
  AUTHORS   Wang,S., Zhang,J., Zhao,A., Hipkens,S., Magnuson,M.A. and Gu,G.
  TITLE     Loss of Myt1 function partially compromises endocrine islet cell
            differentiation and pancreatic physiological function in the mouse
  JOURNAL   Mech Dev 124 (11-12), 898-910 (2007)
   PUBMED   17928203
REFERENCE   7  (residues 1 to 361)
  AUTHORS   Parton,L.E., McMillen,P.J., Shen,Y., Docherty,E., Sharpe,E.,
            Diraison,F., Briscoe,C.P. and Rutter,G.A.
  TITLE     Limited role for SREBP-1c in defective glucose-induced insulin
            secretion from Zucker diabetic fatty rat islets: a functional and
            gene profiling analysis
  JOURNAL   Am J Physiol Endocrinol Metab 291 (5), E982-E994 (2006)
   PUBMED   16772326
REFERENCE   8  (residues 1 to 361)
  AUTHORS   Kato,T., Shimano,H., Yamamoto,T., Yokoo,T., Endo,Y., Ishikawa,M.,
            Matsuzaka,T., Nakagawa,Y., Kumadaki,S., Yahagi,N., Takahashi,A.,
            Sone,H., Suzuki,H., Toyoshima,H., Hasty,A.H., Takahashi,S.,
            Gomi,H., Izumi,T. and Yamada,N.
  TITLE     Granuphilin is activated by SREBP-1c and involved in impaired
            insulin secretion in diabetic mice
  JOURNAL   Cell Metab 4 (2), 143-154 (2006)
   PUBMED   16890542
REFERENCE   9  (residues 1 to 361)
  AUTHORS   Matsuoka,T.A., Zhao,L., Artner,I., Jarrett,H.W., Friedman,D.,
            Means,A. and Stein,R.
  TITLE     Members of the large Maf transcription family regulate insulin gene
            transcription in islet beta cells
  JOURNAL   Mol Cell Biol 23 (17), 6049-6062 (2003)
   PUBMED   12917329
REFERENCE   10 (residues 1 to 361)
  AUTHORS   Kataoka,K., Han,S.I., Shioda,S., Hirai,M., Nishizawa,M. and
            Handa,H.
  TITLE     MafA is a glucose-regulated and pancreatic beta-cell-specific
            transcriptional activator for the insulin gene
  JOURNAL   J Biol Chem 277 (51), 49903-49910 (2002)
   PUBMED   12368292
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000007.1.
            
            On Jan 14, 2022 this sequence version replaced XP_006241965.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582424.300095.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..361
                     /product="transcription factor MafA"
                     /note="v-maf musculoaponeurotic fibrosarcoma oncogene
                     family, protein A; v-maf musculoaponeurotic fibrosarcoma
                     oncogene homolog A; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene A; v-maf avian musculoaponeurotic
                     fibrosarcoma oncogene homolog A; pancreatic
                     beta-cell-specific transcriptional activator"
                     /calculated_mol_wt=37649
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Region          40..105
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            49
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            53
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O57342; propagated from
                     UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Region          111..141
                     /region_name="Maf_N"
                     /note="Maf N-terminal region; pfam08383"
                     /db_xref="CDD:462456"
     Region          175..228
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Region          257..325
                     /region_name="bZIP_Maf_large"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; cd14718"
                     /db_xref="CDD:269866"
     Region          257..325
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269866"
     Region          262..287
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Site            order(264,267..269,271..273,275..277,279..280,282..283)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     Site            order(283,290,293..294,297..298,300..301,304..305,
                     307..308,311,314..315,318..319,321..322)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269866"
     Region          290..311
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZNT6.1)"
     Region          324..361
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZNT6.1)"
     CDS             1..361
                     /gene="Mafa"
                     /gene_synonym="RGD1562627"
                     /coded_by="NM_001399773.1:395..1480"
                     /db_xref="GeneID:366949"
                     /db_xref="RGD:1562627"
ORIGIN      
        1 maaelamgae lpssplaiey vndfdlmkfe vkkeppeaer fchrlppgsl sstplstpcs
       61 svpsspsfca pspgtgssag gggsaaqagg apgppsggpg tvggasgkav ledlywmsgy
      121 qhhlnpealn ltpedaveal igsghhsahh gahhpaaaaa yeafrgqsfa ggggggaddm
      181 gaghhhgahh tahhhhsahh hhhhhhhhgg sghhgggagh ggggaghhvr leerfsddql
      241 vsmsvrelnr qlrgfskeev irlkqkrrtl knrgyaqscr fkrvqqrhil esekcqlqsq
      301 veqlklevgr lakerdlyke kyeklagrgg pggaggagfp repspaqagp gaakgapdff
      361 l
//
LOCUS       NP_001297999             437 aa            linear   ROD 27-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 2 isoform 2 [Mus musculus].
ACCESSION   NP_001297999 XP_011245156
VERSION     NP_001297999.1
DBSOURCE    REFSEQ: accession NM_001311070.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Michaels,J.R., Iyyanar,P.P.R., Husami,A., Vontell,A.M.,
            Brugmann,S.A. and Stottmann,R.W.
  TITLE     Genetic analysis and functional assessment of a TGFBR2 variant in
            micrognathia and cleft palate
  JOURNAL   PLoS One 20 (6), e0324803 (2025)
   PUBMED   40489498
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Hrncir,H.R., Goodloe,B., Bombin,S., Hogan,C.B., Jadi,O. and
            Gracz,A.D.
  TITLE     Sox9 inhibits Activin A to promote biliary maturation and branching
            morphogenesis
  JOURNAL   Nat Commun 16 (1), 1667 (2025)
   PUBMED   39955269
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Dick,A., Risau,W. and Drexler,H.
  TITLE     Expression of Smad1 and Smad2 during embryogenesis suggests a role
            in organ development
  JOURNAL   Dev Dyn 211 (4), 293-305 (1998)
   PUBMED   9566949
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Waldrip,W.R., Bikoff,E.K., Hoodless,P.A., Wrana,J.L. and
            Robertson,E.J.
  TITLE     Smad2 signaling in extraembryonic tissues determines
            anterior-posterior polarity of the early mouse embryo
  JOURNAL   Cell 92 (6), 797-808 (1998)
   PUBMED   9529255
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Devereux,T.R., Anna,C.H., Patel,A.C., White,C.M., Festing,M.F. and
            You,M.
  TITLE     Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1):
            candidates for murine lung tumor resistance and suppressor genes
  JOURNAL   Carcinogenesis 18 (9), 1751-1755 (1997)
   PUBMED   9328171
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Chen,Y., Lebrun,J.J. and Vale,W.
  TITLE     Regulation of transforming growth factor beta- and activin-induced
            transcription by mammalian Mad proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12992-12997 (1996)
   PUBMED   8917532
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Baker,J.C. and Harland,R.M.
  TITLE     A novel mesoderm inducer, Madr2, functions in the activin signal
            transduction pathway
  JOURNAL   Genes Dev 10 (15), 1880-1889 (1996)
   PUBMED   8756346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007817.1, AY334552.1, AC164009.3, BC058713.1, AK078612.1 and
            BM248478.2.
            
            On Jul 21, 2015 this sequence version replaced XP_011245156.1.
            
            Transcript Variant: This variant (3) has a shorter 5' UTR and lacks
            an in-frame exon in the 5' coding region, compared to variant 1.
            The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY334552.1, SRR7345562.2457577.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 51.42 cM"
     Protein         1..437
                     /product="mothers against decapentaplegic homolog 2
                     isoform 2"
                     /note="mothers against decapentaplegic homolog 2;
                     mad-related protein 2; mothers against DPP homolog 2; Smad
                     2; MAD homolog 2"
                     /calculated_mol_wt=48825
     Region          8..142
                     /region_name="MH1_SMAD_2_3"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD2 and
                     SMAD3; cd10491"
                     /db_xref="CDD:199815"
     Site            order(43,47,80,84..88,91,110..111)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199815"
     Site            order(74,119,131,136)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199815"
     Region          236..426
                     /region_name="MH2_SMAD_2_3"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD2 and
                     SMAD3; cd10985"
                     /db_xref="CDD:199826"
     Site            order(253,258..259,261,272..276,280,284,287,289..290,
                     296..297,299..301,304,373,376,379,383,385,389..391,396,
                     398,402,407,409,411,413,416..417,419..420,423..424)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199826"
     CDS             1..437
                     /gene="Smad2"
                     /gene_synonym="7120426M23Rik; Madh2; Madr2; mMad2; Smad-2"
                     /coded_by="NM_001311070.1:48..1361"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS79664.1"
                     /db_xref="GeneID:17126"
                     /db_xref="MGI:MGI:108051"
ORIGIN      
        1 mssilpftpp vvkrllgwkk saggsggagg geqngqeekw cekavkslvk klkktgrlde
       61 lekaittqnc ntkcvtiprs ldgrlqvshr kglphviycr lwrwpdlhsh helkaience
      121 yafnlkkdev cvnpyhyqrv etpvlppvlv prhteiltel pplddythsi pentnfpagi
      181 epqsnyipet pppgyisedg etsdqqlnqs mdtgspaels pttlspvnhs ldlqpvtyse
      241 pafwcsiayy elnqrvgetf hasqpsltvd gftdpsnser fclgllsnvn rnatvemtrr
      301 higrgvrlyy iggevfaecl sdsaifvqsp ncnqrygwhp atvckippgc nlkifnnqef
      361 aallaqsvnq gfeavyqltr mctirmsfvk gwgaeyrrqt vtstpcwiel hlngplqwld
      421 kvltqmgsps vrcssms
//
LOCUS       NP_778154                732 aa            linear   ROD 27-AUG-2025
DEFINITION  TIR domain-containing adapter molecule 1 [Mus musculus].
ACCESSION   NP_778154
VERSION     NP_778154.1
DBSOURCE    REFSEQ: accession NM_174989.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 732)
  AUTHORS   Cho,H.S., Yoo,J.S., Song,X., Goh,B., Diallo,A., Lee,J., Son,S.,
            Hwang,Y.S., Park,S.B., Oh,S.F. and Kasper,D.L.
  TITLE     Structure of gut microbial glycolipid modulates host inflammatory
            response
  JOURNAL   Cell (2025) In press
   PUBMED   40701150
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 732)
  AUTHORS   Yeap,H.W., Goh,G.R., Rosli,S.N., Pung,H.S., Giogha,C., Eng,V.V.,
            Pearson,J.S., Hartland,E.L. and Chen,K.W.
  TITLE     A bacterial network of T3SS effectors counteracts host
            pro-inflammatory responses and cell death to promote infection
  JOURNAL   EMBO J 44 (9), 2424-2445 (2025)
   PUBMED   40128366
REFERENCE   3  (residues 1 to 732)
  AUTHORS   Ball,A.B., Jones,A.E., Nguyen,K.B., Rios,A., Marx,N., Hsieh,W.Y.,
            Yang,K., Desousa,B.R., Kim,K.K.O., Veliova,M., Del Mundo,Z.M.,
            Shirihai,O.S., Beninca,C., Stiles,L., Bensinger,S.J. and
            Divakaruni,A.S.
  TITLE     Pro-inflammatory macrophage activation does not require inhibition
            of oxidative phosphorylation
  JOURNAL   EMBO Rep 26 (4), 982-1002 (2025)
   PUBMED   39753784
REFERENCE   4  (residues 1 to 732)
  AUTHORS   Chan,F.H.M., Yeap,H.W., Liu,Z., Rosli,S.N., Low,K.E., Bonne,I.,
            Wu,Y., Chong,S.Z. and Chen,K.W.
  TITLE     Plasticity of cell death pathways ensures GSDMD activation during
            Yersinia pseudotuberculosis infection
  JOURNAL   Cell Rep 44 (1), 115216 (2025)
   PUBMED   39823227
REFERENCE   5  (residues 1 to 732)
  AUTHORS   Danielson,M., Nicolai,C.J., Vo,T.T., Wolf,N.K. and Burke,T.P.
  TITLE     Cytosolic bacterial pathogens activate TLR pathways in tumors that
            synergistically enhance STING agonist cancer therapies
  JOURNAL   iScience 27 (12), 111385 (2024)
   PUBMED   39669426
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 732)
  AUTHORS   Hoebe,K., Du,X., Georgel,P., Janssen,E., Tabeta,K., Kim,S.O.,
            Goode,J., Lin,P., Mann,N., Mudd,S., Crozat,K., Sovath,S., Han,J.
            and Beutler,B.
  TITLE     Identification of Lps2 as a key transducer of MyD88-independent TIR
            signalling
  JOURNAL   Nature 424 (6950), 743-748 (2003)
   PUBMED   12872135
  REMARK    GeneRIF: Lps2 mutation is a distal frameshift error in Trif or
            Ticam-1; Trif(Lps2) homozygotes are markedly resistant to the toxic
            effects of LPS, and are hypersusceptible to mouse cytomegalovirus,
            failing to produce type I interferons when infected
REFERENCE   7  (residues 1 to 732)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Hoshino,K., Kaisho,T., Sanjo,H.,
            Takeuchi,O., Sugiyama,M., Okabe,M., Takeda,K. and Akira,S.
  TITLE     Role of adaptor TRIF in the MyD88-independent toll-like receptor
            signaling pathway
  JOURNAL   Science 301 (5633), 640-643 (2003)
   PUBMED   12855817
  REMARK    GeneRIF: findings demonstrate that TRIF is essential for TLR3- and
            TLR4-mediated signaling pathways facilitating mammalian antiviral
            host defense
REFERENCE   8  (residues 1 to 732)
  AUTHORS   Oshiumi,H., Matsumoto,M., Funami,K., Akazawa,T. and Seya,T.
  TITLE     TICAM-1, an adaptor molecule that participates in Toll-like
            receptor 3-mediated interferon-beta induction
  JOURNAL   Nat Immunol 4 (2), 161-167 (2003)
   PUBMED   12539043
  REMARK    GeneRIF: identified an alternative adaptor, designated
            Toll-interleukin 1 receptor domain (TIR)-containing adaptor
            molecule (TICAM)-1, that can physically bind the TIR domain of TLR3
REFERENCE   9  (residues 1 to 732)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
REFERENCE   10 (residues 1 to 732)
  AUTHORS   Yamamoto,M., Sato,S., Mori,K., Hoshino,K., Takeuchi,O., Takeda,K.
            and Akira,S.
  TITLE     Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter
            that preferentially activates the IFN-beta promoter in the
            Toll-like receptor signaling
  JOURNAL   J Immunol 169 (12), 6668-6672 (2002)
   PUBMED   12471095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026385.19.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037048.2, AK054219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.24 cM"
     Protein         1..732
                     /product="TIR domain-containing adapter molecule 1"
                     /note="TIR domain-containing adaptor inducing
                     interferon-beta; toll-like receptor adaptor molecule 1;
                     TIR domain-containing adapter protein inducing IFN-beta;
                     toll-interleukin-1 receptor domain-containing adapter
                     protein inducing interferon beta"
                     /calculated_mol_wt=79099
     Region          1..153
                     /region_name="TRIF-NTD.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          1..148
                     /region_name="TRIF-NTD"
                     /note="TRIF N-terminal domain; pfam17798"
                     /db_xref="CDD:436052"
     Region          84..91
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          144..191
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          206..209
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Site            209
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6; propagated from
                     UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          247..254
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          296..306
                     /region_name="TRAF6-binding.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          305..389
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          399..516
                     /region_name="TIR_2"
                     /note="TIR domain; pfam13676"
                     /db_xref="CDD:463954"
     Region          514..713
                     /region_name="Sufficient to induce apoptosis.
                     /evidence=ECO:0000250|UniProtKB:Q8IUC6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          603..679
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     Region          678..697
                     /region_name="RHIM"
                     /note="RIP homotypic interaction motif; pfam12721"
                     /db_xref="CDD:463679"
     Region          696..732
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UF7.1)"
     CDS             1..732
                     /gene="Ticam1"
                     /gene_synonym="TICAM-1; TRIF"
                     /coded_by="NM_174989.5:199..2397"
                     /db_xref="CCDS:CCDS28900.1"
                     /db_xref="GeneID:106759"
                     /db_xref="MGI:MGI:2147032"
ORIGIN      
        1 mdnpgpslrg afgilgaler drlthlkhkl gslcsgsqes kllhamvlla lgqdtearvs
       61 leslkmntva qlvahqwadm ettegpeepp dlswtvarly hllaeenlcp astrdmayqv
      121 alrdfasqgd hqlgqlqnea wdrcssdikg dpsgfqplhs hqgslqppsa spavtrsqpr
      181 pidtpdwswg htlhstnsta slashleisq sptlaflssh hgthgpsklc ntpldtqepq
      241 lvpegcqepe eiswppsvet svslglphei svpevspeea spilpdalaa pdtsvhcpie
      301 ctelstnsrs pltsttesvg kqwpitsqrs pqvpvgddsl qnttsssppa qppslqaspk
      361 lppsplssas spssypappt stspvldhse tsdqkfynfv viharadeqv alrireklet
      421 lgvpdgatfc eefqvpgrge lhclqdaidh sgftilllta sfdcslslhq inhalmnslt
      481 qsgrqdcvip llplecsqaq lspdttrllh sivwldehsp ifarkvantf ktqklqaqrv
      541 rwkkaqeart lkeqsiqlea erqnvaaisa aytayvhsyr awqaemnklg vafgknlslg
      601 tptpswpgcp qpipshpqgg tpvfpyspqp psfpqppcfp qppsfpqpps fplppvsspq
      661 sqsfpsassp apqtpgpqpl iihhaqmvql gvnnhmwght gaqssddkte csenpcmgpl
      721 tdqgepllet pe
//
LOCUS       NP_001351551             702 aa            linear   ROD 27-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform 5 [Mus musculus].
ACCESSION   NP_001351551 XP_006515490
VERSION     NP_001351551.1
DBSOURCE    REFSEQ: accession NM_001364622.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 702)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 702)
  AUTHORS   Ishikawa,M., Osaki,M., Uno,N., Ohira,T., Kugoh,H. and Okada,F.
  TITLE     MTA1, a metastasis-associated protein, in endothelial cells is an
            essential molecule for angiogenesis
  JOURNAL   Mol Med Rep 25 (1) (2022)
   PUBMED   34779499
  REMARK    GeneRIF: MTA1, a metastasisassociated protein, in endothelial cells
            is an essential molecule for angiogenesis.
REFERENCE   4  (residues 1 to 702)
  AUTHORS   Yan,L., Jin,W., Zhao,Q., Cui,X., Shi,T., Xu,Y., Li,F., Jin,W.,
            Zhang,Z., Zhang,Z., Tang,Q.Q. and Pan,D.
  TITLE     PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a
            NuRD Subcomplex
  JOURNAL   Adv Sci (Weinh) 8 (16), e2102060 (2021)
   PUBMED   34180153
REFERENCE   5  (residues 1 to 702)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 702)
  AUTHORS   Kiefer,S.M., McDill,B.W., Yang,J. and Rauchman,M.
  TITLE     Murine Sall1 represses transcription by recruiting a histone
            deacetylase complex
  JOURNAL   J Biol Chem 277 (17), 14869-14876 (2002)
   PUBMED   11836251
REFERENCE   7  (residues 1 to 702)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (residues 1 to 702)
  AUTHORS   Osterod,M., Hollenbach,S., Hengstler,J.G., Barnes,D.E., Lindahl,T.
            and Epe,B.
  TITLE     Age-related and tissue-specific accumulation of oxidative DNA base
            damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient
            mice
  JOURNAL   Carcinogenesis 22 (9), 1459-1463 (2001)
   PUBMED   11532868
REFERENCE   9  (residues 1 to 702)
  AUTHORS   Simpson,A., Uitto,J., Rodeck,U. and Mahoney,M.G.
  TITLE     Differential expression and subcellular distribution of the mouse
            metastasis-associated proteins Mta1 and Mta3
  JOURNAL   Gene 273 (1), 29-39 (2001)
   PUBMED   11483358
REFERENCE   10 (residues 1 to 702)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073562.6.
            
            On Jun 26, 2018 this sequence version replaced XP_006515490.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB794103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.57 cM"
     Protein         1..702
                     /product="metastasis-associated protein MTA1 isoform 5"
                     /note="metastasis-associated protein MTA1"
                     /calculated_mol_wt=79493
     Region          3..171
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          150..202
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          270..315
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(271,301..302,304..305,307..309,311..313)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          371..424
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          447..524
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..702
                     /gene="Mta1"
                     /coded_by="NM_001364622.1:141..2249"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:116870"
                     /db_xref="MGI:MGI:2150037"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd issslialad
       61 khareveeev enpemvdlpe klkhqlrhre lflsrqlesl pathirgkcs vtllnetesl
      121 ksyleredff fyslvydpqq ktlladkgei rvgnryqadi tdllkegeed grdqskletk
      181 vweahnplvd kqidqflvva rsvgtfaral dcsssvrqps lhmsaaaasr ditlfhamdt
      241 lhkniydisk aisalvpqgg pvlcrdemee wsaseanlfe ealekygkdf tdiqqdflpw
      301 ksltsiieyy ymwkttdryv qqkrlkaaea esklkqvyip nynkpnpnqi sassvkatvv
      361 ngtgtpgqsp gagracescy ttqsyqwysw gppnmqcrlc ascwtywkky gglkmptrld
      421 gerpgpnrnn msphgipars sgspkfamkt rqafylhttk ltriarrlcr eilrpwhaar
      481 hpympinsaa ikaectarlp easqsplvlk qvvrkpleav lrylethprp pkpdpvksss
      541 svlssltpak sapvinngsp tilgkrsyeq hngvdgnmkk rllmpsrgty lglanhgqtr
      601 hmgpsrnlll ngksyptkvr lirggslppv krrrmnwida pddvfymate etrkirklls
      661 ssetkraarr pykpialrqs qalplrpppp apvndepivi ed
//
LOCUS       NP_001299837            1426 aa            linear   ROD 27-AUG-2025
DEFINITION  homeobox protein cut-like 2 isoform 1 [Mus musculus].
ACCESSION   NP_001299837 XP_011246477
VERSION     NP_001299837.1
DBSOURCE    REFSEQ: accession NM_001312908.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1426)
  AUTHORS   Haziza,S., Chrapkiewicz,R., Zhang,Y., Kruzhilin,V., Li,J., Li,J.,
            Delamare,G., Swanson,R., Buzsaki,G., Kannan,M., Vasan,G., Lin,M.Z.,
            Zeng,H., Daigle,T.L. and Schnitzer,M.J.
  TITLE     Imaging high-frequency voltage dynamics in multiple neuron classes
            of behaving mammals
  JOURNAL   Cell 188 (16), 4401-4423 (2025)
   PUBMED   40675148
  REMARK    Erratum:[Cell. 2025 Aug 21:S0092-8674(25)00924-9. doi:
            10.1016/j.cell.2025.08.010. PMID: 40845837]
REFERENCE   2  (residues 1 to 1426)
  AUTHORS   Sun,L., Xiong,F., Huang,F., Dong,S., Zhu,P., Jiang,P., Zhang,B.,
            Zhang,X., Sun,J., Peng,H. and Zhao,C.
  TITLE     Transcriptomic insights into fate choice of pallial versus
            subpallial GABAergic neurons
  JOURNAL   Nat Commun 16 (1), 5032 (2025)
   PUBMED   40447563
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1426)
  AUTHORS   Sudarsanam,S., Guzman-Clavel,L.E., Dar,N., Ziak,J., Shahid,N.,
            Jin,X.O. and Kolodkin,A.L.
  TITLE     Mef2c Controls Postnatal Callosal Axon Targeting by Regulating
            Sensitivity to Ephrin Repulsion
  JOURNAL   J Neurosci 45 (21), e0201252025 (2025)
   PUBMED   40228894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1426)
  AUTHORS   Martin-Lopez,E., Brennan,B., Lefevre,M., Spence,N.J., Han,K. and
            Greer,C.A.
  TITLE     Laminar organization of the anterior olfactory nucleus-the
            interplay between neurogenesis timing and neuroblast migration
  JOURNAL   Front Neurosci 19, 1546397 (2025)
   PUBMED   40370659
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1426)
  AUTHORS   Cocito,C., Xiang,C., Huang,M., Gongora,T., Surana,P., Davuluri,R.,
            Dahmane,N. and Greenfield,J.P.
  TITLE     Immunoglobulin superfamily 3 (Igsf3) function is dispensable for
            brain development
  JOURNAL   Sci Rep 15 (1), 6526 (2025)
   PUBMED   39988603
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1426)
  AUTHORS   Iulianella,A., Vanden Heuvel,G. and Trainor,P.
  TITLE     Dynamic expression of murine Cux2 in craniofacial, limb, urogenital
            and neuronal primordia
  JOURNAL   Gene Expr Patterns 3 (5), 571-577 (2003)
   PUBMED   12971989
REFERENCE   7  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Quaggin,S.E. and Igarashi,P.
  TITLE     A unique variant of a homeobox gene related to Drosophila cut is
            expressed in mouse testis
  JOURNAL   Biol Reprod 55 (4), 731-739 (1996)
   PUBMED   8879483
REFERENCE   8  (residues 1 to 1426)
  AUTHORS   Quaggin,S.E., Heuvel,G.B., Golden,K., Bodmer,R. and Igarashi,P.
  TITLE     Primary structure, neural-specific expression, and chromosomal
            localization of Cux-2, a second murine homeobox gene related to
            Drosophila cut
  JOURNAL   J Biol Chem 271 (37), 22624-22634 (1996)
   PUBMED   8798433
REFERENCE   9  (residues 1 to 1426)
  AUTHORS   Vanden Heuvel,G.B., Bodmer,R., McConnell,K.R., Nagami,G.T. and
            Igarashi,P.
  TITLE     Expression of a cut-related homeobox gene in developing and
            polycystic mouse kidney
  JOURNAL   Kidney Int 50 (2), 453-461 (1996)
   PUBMED   8840273
REFERENCE   10 (residues 1 to 1426)
  AUTHORS   Valarche,I., Tissier-Seta,J.P., Hirsch,M.R., Martinez,S.,
            Goridis,C. and Brunet,J.F.
  TITLE     The mouse homeodomain protein Phox2 regulates Ncam promoter
            activity in concert with Cux/CDP and is a putative determinant of
            neurotransmitter phenotype
  JOURNAL   Development 119 (3), 881-896 (1993)
   PUBMED   7910552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140353.2 and AC113302.13.
            
            On Aug 22, 2015 this sequence version replaced XP_011246477.1.
            
            Summary: This gene is a member of the Cut family of transcription
            factors that have multiple DNA binding domains and regulate cell
            proliferation and differentiation. This gene is primarily expressed
            in nervous tissues where it controls the proliferation of neuronal
            precursors, and may play a role in organogenesis earlier during
            embryonic development. Mice lacking the encoded protein exhibit
            smaller spinal cords with deficits in neural progenitor development
            as well as in neuroblast and interneuron differentiation.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U45665.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.02 cM"
     Protein         1..1426
                     /product="homeobox protein cut-like 2 isoform 1"
                     /note="homeobox protein cut-like 2; homeobox protein
                     Cux-2"
                     /calculated_mol_wt=154533
     Region          77..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Site            81
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14529; propagated from
                     UniProtKB/Swiss-Prot (P70298.2)"
     Region          <116..>316
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          351..419
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          460..488
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          487..563
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          599..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          653..676
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          743..769
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          833..906
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          904..977
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     Region          988..1064
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:460543"
     Region          1114..1170
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1177..1392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70298.2)"
     CDS             1..1426
                     /gene="Cux2"
                     /gene_synonym="1700051K22Rik; Cutl2; Cux-2"
                     /coded_by="NM_001312908.2:290..4570"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39251.1"
                     /db_xref="GeneID:13048"
                     /db_xref="MGI:MGI:107321"
ORIGIN      
        1 mvapvlksfq aevvalskrs reaeaaflsv ykqlieapdp vpsfevartl ddrlqrpsfd
       61 psgqrlqdvh iawkrcpepp sareqnegtc ptghtpangn hlpgpedtlv tdtllqknea
      121 erqkglqevh itlaarlgea eekikvlhsa lkatqtelle lrrkydeeaa skadevglim
      181 tnlekanqra eaaqrevesl reqlasvnss irlaccspqg psgekvsfal csgprleaal
      241 askdreilrl lkdaqqlrhs lqeleevsan qiadlerqla akseaieklq ekleaqadye
      301 eiktelsilr amklasstcs lpqtlakpdd pllvakdvff ptqkfllekp allaspeedp
      361 seddsikgsl gteppyppql ppppgpedpl spspaqpllg pslgpdgprt fslspfpsla
      421 pgerlagdsl lskhmmgpaa fkgetgnlla fpptfyggak ppsapaasvp cpeptgapea
      481 vdgagpeeeq ldtaeiafqv keqllkhnig qrvfghyvlg lsqgsvseil arpkpwrklt
      541 vkgkepfikm kqflsdeqnv lalrtiqvrq rgsitprirt petgsddaik sileqakkei
      601 esqkggeskn spasvsipng tassstseda iknileqarr emqaqqqall emesgprgrs
      661 vppspperps patasqngal tcvkqedggg gsgssstvqa plavlspaaf vqriirkvks
      721 eigdagyfdh hwasdrglls rpyasvspsl sssssysgqp ngrawprgde atiapedeaa
      781 mgedeaprvg elkaeagape vgggrlpyyp ayvprtlkpt vppltpeqye lymyrevdtl
      841 eltrqvkekl akngicqrif gekvlglsqg svsdmlsrpk pwskltqkgr epfirmqlwl
      901 sdqlgqgqgq aptqqpsasq aspteptssp spppsptepe ktsqeplgls lesskenqqp
      961 egrassslgg kpfsssqaag giqemvamsp eldtysitkr vkevltdnnl gqrlfgesil
     1021 gltqgsvsdl lsrpkpwhkl slkgrepfvr mqlwlsdphn veklrdmkkl ekkaylkrry
     1081 gligtgsdse spaahsecps pclqpqelsl mqakkprvvl apaekealrk ayqlepypsq
     1141 qtiellsfql nlktntvinw fhnyrsrmrr emlvegtqdd pdfdpsggpn vltpghthre
     1201 ptpqspdset edqkppmksl elqepegplq raapdralvk ikqeeglevd gdsqpqdvgd
     1261 pdrgqdgpke ehthplgnsd lselapgpfl sgtpnpdcps lhnpqekgtg eqvhseplsf
     1321 kstsessccs legppnspsv isspdlttcv spapsssapi spslpgappa kvpstsptgd
     1381 taaalhpstk vnpnlqrrhe kmanlnsiiy rleraanree vlewef
//
LOCUS       NP_033005                802 aa            linear   ROD 27-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Mus
            musculus].
ACCESSION   NP_033005
VERSION     NP_033005.1
DBSOURCE    REFSEQ: accession NM_008979.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 802)
  AUTHORS   Acero-Bedoya,S., Higgs,E.F., Martinez,A.C., Tonea,R. and
            Gajewski,T.F.
  TITLE     Dendritic cell-intrinsic PTPN22 negatively regulates antitumor
            immunity and impacts anti-PD-L1 efficacy
  JOURNAL   J Immunother Cancer 12 (10), e009588 (2024)
   PUBMED   39461876
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 802)
  AUTHORS   Cai,H., Chen,S., Jiang,Z., Chen,L. and Yang,X.
  TITLE     PTPN22 through the regulation of Th17/Treg balance acts as a
            potential target for the treatment of Graves' disease
  JOURNAL   Tissue Cell 90, 102502 (2024)
   PUBMED   39083881
  REMARK    GeneRIF: PTPN22 through the regulation of Th17/Treg balance acts as
            a potential target for the treatment of Graves' disease.
REFERENCE   3  (residues 1 to 802)
  AUTHORS   Lee,J., Yurkovetskiy,L.A., Reiman,D., Frommer,L., Strong,Z.,
            Chang,A., Kahaly,G.J., Khan,A.A. and Chervonsky,A.V.
  TITLE     Androgens contribute to sex bias of autoimmunity in mice by T
            cell-intrinsic regulation of Ptpn22 phosphatase expression
  JOURNAL   Nat Commun 15 (1), 7688 (2024)
   PUBMED   39227386
  REMARK    GeneRIF: Androgens contribute to sex bias of autoimmunity in mice
            by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 802)
  AUTHORS   Orozco,R.C., Marquardt,K., Pratumchai,I., Shaikh,A.F., Mowen,K.,
            Domissy,A., Teijaro,J.R. and Sherman,L.A.
  TITLE     Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22
            enhances anti-viral immunity
  JOURNAL   PLoS Pathog 20 (3), e1012095 (2024)
   PUBMED   38512979
  REMARK    GeneRIF: Autoimmunity-associated allele of tyrosine phosphatase
            gene PTPN22 enhances anti-viral immunity.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 802)
  AUTHORS   Li,S., Luo,Z., Su,S., Wen,L., Xian,G., Zhao,J., Xu,X., Xu,D. and
            Zeng,Q.
  TITLE     Targeted inhibition of PTPN22 is a novel approach to alleviate
            osteogenic responses in aortic valve interstitial cells and aortic
            valve lesions in mice
  JOURNAL   BMC Med 21 (1), 252 (2023)
   PUBMED   37443055
  REMARK    GeneRIF: Targeted inhibition of PTPN22 is a novel approach to
            alleviate osteogenic responses in aortic valve interstitial cells
            and aortic valve lesions in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 802)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (residues 1 to 802)
  AUTHORS   Gjorloff-Wingren,A., Saxena,M., Han,S., Wang,X., Alonso,A.,
            Renedo,M., Oh,P., Williams,S., Schnitzer,J. and Mustelin,T.
  TITLE     Subcellular localization of intracellular protein tyrosine
            phosphatases in T cells
  JOURNAL   Eur J Immunol 30 (8), 2412-2421 (2000)
   PUBMED   10940933
REFERENCE   8  (residues 1 to 802)
  AUTHORS   Gregorieff,A., Cloutier,J.F. and Veillette,A.
  TITLE     Sequence requirements for association of protein-tyrosine
            phosphatase PEP with the Src homology 3 domain of inhibitory
            tyrosine protein kinase p50(csk)
  JOURNAL   J Biol Chem 273 (21), 13217-13222 (1998)
   PUBMED   9582365
REFERENCE   9  (residues 1 to 802)
  AUTHORS   Cloutier,J.F. and Veillette,A.
  TITLE     Association of inhibitory tyrosine protein kinase p50csk with
            protein tyrosine phosphatase PEP in T cells and other hemopoietic
            cells
  JOURNAL   EMBO J 15 (18), 4909-4918 (1996)
   PUBMED   8890164
REFERENCE   10 (residues 1 to 802)
  AUTHORS   Matthews,R.J., Bowne,D.B., Flores,E. and Thomas,M.L.
  TITLE     Characterization of hematopoietic intracellular protein tyrosine
            phosphatases: description of a phosphatase containing an SH2 domain
            and another enriched in proline-, glutamic acid-, serine-, and
            threonine-rich sequences
  JOURNAL   Mol Cell Biol 12 (5), 2396-2405 (1992)
   PUBMED   1373816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124698.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M90388.1, BC055377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.52 cM"
     Protein         1..802
                     /product="tyrosine-protein phosphatase non-receptor type
                     22 isoform 1"
                     /EC_number="3.1.3.48"
                     /note="protein tyrosine phosphatase, non-receptor type 8;
                     PEST domain-enriched tyrosine phosphatase;
                     tyrosine-protein phosphatase non-receptor type 22;
                     hematopoietic cell protein-tyrosine phosphatase 70Z-PEP"
                     /calculated_mol_wt=89584
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCD.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2R2; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          57..290
                     /region_name="PTPc-N22"
                     /note="catalytic domain of tyrosine-protein phosphatase
                     non-receptor type 22; cd14602"
                     /db_xref="CDD:350450"
     Region          330..358
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          536..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          597..619
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Region          613..621
                     /region_name="Interaction with CSK.
                     /evidence=ECO:0000269|PubMed:8890164"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            634
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          653..695
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     Site            680
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Site            687
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P29352.1)"
     Region          713..802
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P29352.1)"
     CDS             1..802
                     /gene="Ptpn22"
                     /gene_synonym="70zpep; PEP; Ptpn8"
                     /coded_by="NM_008979.3:125..2533"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38577.1"
                     /db_xref="GeneID:19260"
                     /db_xref="MGI:MGI:107170"
ORIGIN      
        1 mdqreilqql lkeaqkkkln seefaseflk lkrqstkyka dkiypttvaq rpknikknry
       61 kdilpydhsl velslltsde dssyinasfi kgvygpkayi atqgplsttl ldfwrmiwey
      121 rilvivmacm efemgkkkce rywaepgetq lqfgpfsisc eaekkksdyk irtlkakfnn
      181 etriiyqfhy knwpdhdvps sidpilqliw dmrcyqeddc vpicihcsag cgrtgvicav
      241 dytwmllkdg iipknfsvfn liqemrtqrp slvqtqeqye lvysavlelf krhmdvisdn
      301 hlgreiqaqc sipeqsltve adscpldlpk namrdvkttn qhskqgaeae stggsslglr
      361 tstmnaeeel vlhsakssps fnclelncgc nnkavitrng qaraspvvge plqkyqsldf
      421 gsmlfgscps alpintadry hnskgpvkrt kstpfeliqq rktndlavgd gfsclesqlh
      481 ehyslrelqv qrvahvssee lnyslpgacd ascvprhspg alrvhlytsl aedpyfsssp
      541 pnsadskmsf dlpekqdgat spgallpass ttsffysnph dslvmntlts fspplnqeta
      601 veapsrrtdd eippplpert pesfivveea gepsprvtes lplvvtfgas pecsgtsemk
      661 shdsvgftps knvklrspks drhqdgsppp plpertlesf fladedciqa qavqtsstsy
      721 pettenstss kqtlrtpgks ftrskslkif rnmkksvcns sspskpterv qpknsssfln
      781 fgfgnrfskp kgprnppsaw nm
//
LOCUS       NP_001029126             128 aa            linear   ROD 27-AUG-2025
DEFINITION  calcitonin gene-related peptide 1 isoform Cgrp preproprotein [Mus
            musculus].
ACCESSION   NP_001029126
VERSION     NP_001029126.1
DBSOURCE    REFSEQ: accession NM_001033954.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 128)
  AUTHORS   Haidar,H., Bellon,A., Sleiman,K., Hocine,M., Rama,N., Gadot,N.,
            Carpizo,D.R., Mehlen,P. and Mann,F.
  TITLE     Neural function of Netrin-1 in precancerous lesions of the pancreas
  JOURNAL   Nat Commun 16 (1), 7094 (2025)
   PUBMED   40753071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 128)
  AUTHORS   Liu,L., Gao,Z., Niu,X., Yu,H., Xin,X., Gu,Y., Ma,G., Gu,Y., Liu,Y.,
            Fang,S., Marquardt,T. and Wang,L.
  TITLE     SEMA3B switches axon-axon to axon-glia interactions required for
            unmyelinated axon envelopment and integrity
  JOURNAL   Nat Commun 16 (1), 5433 (2025)
   PUBMED   40595635
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 128)
  AUTHORS   Santiago,C., Siegrist,J., Africawala,N., Handler,A., Tasnim,A.,
            Anjum,R., Turecek,J., Lehnert,B.P., Renauld,S., Choi,J.,
            Nolan-Tamariz,M., Iskols,M., Magee,A.R., Paradis,S., Sharma,N. and
            Ginty,D.D.
  TITLE     Activity-dependent development of the body's touch receptors
  JOURNAL   Neuron 113 (11), 1758-1773 (2025)
   PUBMED   40381613
REFERENCE   4  (residues 1 to 128)
  AUTHORS   Szemes,T., Sabate San Jose,A., Azouz,A., Sitte,M., Salinas,G.,
            Achouri,Y., Kricha,S., Ris,L., Red-Horse,K., Bellefroid,E.J. and
            Desiderio,S.
  TITLE     Temporal refinement of Dach1 expression contributes to the
            development of somatosensory neurons
  JOURNAL   EMBO J 44 (10), 2882-2905 (2025)
   PUBMED   40205161
REFERENCE   5  (residues 1 to 128)
  AUTHORS   Zhi,X., Wu,F., Qian,J., Ochiai,Y., Lian,G., Malagola,E., Zheng,B.,
            Tu,R., Zeng,Y., Kobayashi,H., Xia,Z., Wang,R., Peng,Y., Shi,Q.,
            Chen,D., Ryeom,S.W. and Wang,T.C.
  TITLE     Nociceptive neurons promote gastric tumour progression via a
            CGRP-RAMP1 axis
  JOURNAL   Nature 640 (8059), 802-810 (2025)
   PUBMED   39972142
REFERENCE   6  (residues 1 to 128)
  AUTHORS   Ahren,B. and Sundler,F.
  TITLE     Localization of calcitonin gene-related peptide and islet amyloid
            polypeptide in the rat and mouse pancreas
  JOURNAL   Cell Tissue Res 269 (2), 315-322 (1992)
   PUBMED   1423499
REFERENCE   7  (residues 1 to 128)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   8  (residues 1 to 128)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   9  (residues 1 to 128)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   10 (residues 1 to 128)
  AUTHORS   Lalley,P.A., Sakaguchi,A.Y., Eddy,R.L., Honey,N.H., Bell,G.I.,
            Shen,L.P., Rutter,W.J., Jacobs,J.W., Heinrich,G., Chin,W.W. et al.
  TITLE     Mapping polypeptide hormone genes in the mouse: somatostatin,
            glucagon, calcitonin, and parathyroid hormone
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 92-97 (1987)
   PUBMED   2882956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ060164.1, BC028771.1,
            BB749493.1 and BU842988.1.
            
            Summary: This gene encodes the peptide hormones calcitonin,
            calcitonin gene-related peptide (CGRP) and katacalcin. Alternative
            splicing of the mRNA results in multiple variants that encode
            either calcitonin or CGRP preproproteins. Post-translational
            processing of the calcitonin and CGRP propeptides results in either
            calcitonin and katacalcin, or CGRP, respectively. Calcitonin and
            katacalcin modulate calcium levels in the blood stream. CGRP can
            function as a vasodilator and play a role in the transmission of
            pain. The human homolog of CGRP was found to have antimicrobial
            activity. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (2) lacks the 3' terminal exon and
            has two alternate 3' exons, compared to variant 1. The resulting
            isoform (Cgrp) is shorter and has a distinct C-terminus, compared
            to isoform Calca. Both variants 2 and 3 encode the same isoform
            Cgrp.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028771.1, AF330212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.99 cM"
     Protein         1..128
                     /product="calcitonin gene-related peptide 1 isoform Cgrp
                     preproprotein"
                     /note="alpha-type CGRP; calcitonin gene-related peptide I"
                     /calculated_mol_wt=11294
     Region          1..123
                     /region_name="Calc_CGRP_IAPP"
                     /note="Calcitonin / CGRP / IAPP family; pfam00214"
                     /db_xref="CDD:459715"
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2789
     mat_peptide     83..119
                     /product="Calcitonin gene-related peptide 1.
                     /id=PRO_0000004060"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JA0.1)"
                     /calculated_mol_wt=3809
     Site            119
                     /site_type="amidation"
                     /note="Phenylalanine amide. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q99JA0.1)"
     CDS             1..128
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /coded_by="NM_001033954.3:156..542"
                     /note="isoform Cgrp preproprotein is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS21762.1"
                     /db_xref="GeneID:12310"
                     /db_xref="MGI:MGI:2151253"
ORIGIN      
        1 mgflkfspfl vvsilllyqa cslqavplrs ilesspgmat lseeevrlla alvqdymqmk
       61 areleqeeeq eaegssvtaq krscntatcv thrlagllsr sggvvkdnfv ptnvgseafg
      121 rrrrdlqa
//
LOCUS       NP_001408093             393 aa            linear   ROD 27-AUG-2025
DEFINITION  ELAV-like protein 4 isoform r [Mus musculus].
ACCESSION   NP_001408093 XP_006502858
VERSION     NP_001408093.1
DBSOURCE    REFSEQ: accession NM_001421164.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 393)
  AUTHORS   Taroc,E.Z.M., Amato,E. Jr., Semon,A.M., Dolphin,N., Beck,B.,
            Belin,S., Poitelon,Y. and Forni,P.E.
  TITLE     Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially
            Impact Schwann and Olfactory Ensheathing Cell Development Without
            Disrupting GnRH-1 Migration
  JOURNAL   Glia 73 (10), 2077-2097 (2025)
   PUBMED   40631762
REFERENCE   2  (residues 1 to 393)
  AUTHORS   Amato,E. Jr., Semon,A.M. and Forni,P.E.
  TITLE     Tracing Early Migratory Neurons in the Developing Nose Using
            Contactin-2 (Cntn2) CreERT2
  JOURNAL   Genesis 63 (4), e70021 (2025)
   PUBMED   40580015
REFERENCE   3  (residues 1 to 393)
  AUTHORS   Gurjar,M., Amanipour,R., Balendran,V., Ghimire,S., Demirhan,M.A.,
            Flynn,A.J., Seernaum,N., Rose,K.P., Song,Y., Hertzano,R. and
            Coate,T.M.
  TITLE     EPHRIN-A1 and -A2 act as positive growth factors for developing
            spiral ganglion radial bundles
  JOURNAL   Dev Biol 524, 176-189 (2025)
   PUBMED   40345476
REFERENCE   4  (residues 1 to 393)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   5  (residues 1 to 393)
  AUTHORS   Shimaoka,K., Hori,K., Miyashita,S., Inoue,Y.U., Tabe,N.K.N.,
            Sakamoto,A., Hasegawa,I., Nishitani,K., Yamashiro,K., Egusa,S.F.,
            Tatsumoto,S., Go,Y., Abe,M., Sakimura,K., Inoue,T., Imamura,T. and
            Hoshino,M.
  TITLE     The microcephaly-associated transcriptional regulator AUTS2
            cooperates with Polycomb complex PRC2 to produce upper-layer
            neurons in mice
  JOURNAL   EMBO J 44 (5), 1354-1378 (2025)
   PUBMED   39815005
REFERENCE   6  (residues 1 to 393)
  AUTHORS   Okano,H.J. and Darnell,R.B.
  TITLE     A hierarchy of Hu RNA binding proteins in developing and adult
            neurons
  JOURNAL   J Neurosci 17 (9), 3024-3037 (1997)
   PUBMED   9096138
REFERENCE   7  (residues 1 to 393)
  AUTHORS   Sakakibara,S., Imai,T., Hamaguchi,K., Okabe,M., Aruga,J.,
            Nakajima,K., Yasutomi,D., Nagata,T., Kurihara,Y., Uesugi,S.,
            Miyata,T., Ogawa,M., Mikoshiba,K. and Okano,H.
  TITLE     Mouse-Musashi-1, a neural RNA-binding protein highly enriched in
            the mammalian CNS stem cell
  JOURNAL   Dev Biol 176 (2), 230-242 (1996)
   PUBMED   8660864
REFERENCE   8  (residues 1 to 393)
  AUTHORS   Abe,R., Yamamoto,K. and Sakamoto,H.
  TITLE     Target specificity of neuronal RNA-binding protein, Mel-N1: direct
            binding to the 3' untranslated region of its own mRNA
  JOURNAL   Nucleic Acids Res 24 (11), 2011-2016 (1996)
   PUBMED   8668530
REFERENCE   9  (residues 1 to 393)
  AUTHORS   Abe,R., Uyeno,Y., Yamamoto,K. and Sakamoto,H.
  TITLE     Tissue-specific expression of the gene encoding a mouse RNA binding
            protein homologous to human HuD antigen
  JOURNAL   DNA Res 1 (4), 175-180 (1994)
   PUBMED   8535975
REFERENCE   10 (residues 1 to 393)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627425.15 and AL627206.20.
            
            On May 11, 2023 this sequence version replaced XP_006502858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.1355852.1,
                                           SRR17784643.711113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.42 cM"
     Protein         1..393
                     /product="ELAV-like protein 4 isoform r"
                     /note="ELAV-like protein 4; RNA-binding protein HUD3;
                     paraneoplastic encephalomyelitis antigen HuD; HU-antigen
                     D; ELAV (embryonic lethal, abnormal vision,
                     Drosophila)-like 4 (Hu antigen D)"
                     /calculated_mol_wt=43065
     Region          56..392
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     CDS             1..393
                     /gene="Elavl4"
                     /gene_synonym="Elav; Hud; PNEM"
                     /coded_by="NM_001421164.1:257..1438"
                     /note="isoform r is encoded by transcript variant 21"
                     /db_xref="GeneID:15572"
                     /db_xref="MGI:MGI:107427"
ORIGIN      
        1 mfeisrtlna allnneiist mepqvsngpt sntsngpssn nrncpspmqt gaatddsktn
       61 livnylpqnm tqeefrslfg sigeiesckl vrdkitgqsl gygfvnyidp kdaekaintl
      121 nglrlqtkti kvsyarpssa sirdanlyvs glpktmtqke leqlfsqygr iitsrilvdq
      181 vtgvsrgvgf irfdkrieae eaikglngqk psgatepitv kfannpsqks sqallsqlyq
      241 spnrrypgpl hhqaqrfrld nllnmaygvk rlmsgpvpps acpprfspit idgmtslvgm
      301 nipghtgtgw cifvynlspd sdesvlwqlf gpfgavnnvk virdfntnkc kgfgfvtmtn
      361 ydeaamaias lngyrlgdrv lqvsfktnka hks
//
LOCUS       NP_001297588             158 aa            linear   ROD 27-AUG-2025
DEFINITION  insulin-like growth factor-binding protein 2 isoform 2 [Mus
            musculus].
ACCESSION   NP_001297588 XP_006495770
VERSION     NP_001297588.1
DBSOURCE    REFSEQ: accession NM_001310659.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 158)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 158)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   3  (residues 1 to 158)
  AUTHORS   Yoshimura,Y., Watanabe,T., Nakamura,K., Futatsugi,A., Mikoshiba,K.
            and Hiyama,T.Y.
  TITLE     High-temperature exposure during the early embryonic stage lowers
            core body temperature after growth via a hypothalamic
            Igfbp2-dependent mechanism
  JOURNAL   Sci Rep 14 (1), 29586 (2024)
   PUBMED   39627352
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 158)
  AUTHORS   Wang,Z., Li,Z., Luan,T., Cui,G., Shu,S., Liang,Y., Zhang,K.,
            Xiao,J., Yu,W., Cui,J., Li,A., Peng,G. and Fang,Y.
  TITLE     A spatiotemporal molecular atlas of mouse spinal cord injury
            identifies a distinct astrocyte subpopulation and therapeutic
            potential of IGFBP2
  JOURNAL   Dev Cell 59 (20), 2787-2803 (2024)
   PUBMED   39029468
  REMARK    GeneRIF: A spatiotemporal molecular atlas of mouse spinal cord
            injury identifies a distinct astrocyte subpopulation and
            therapeutic potential of IGFBP2.
REFERENCE   5  (residues 1 to 158)
  AUTHORS   Shigetomi,E., Suzuki,H., Hirayama,Y.J., Sano,F., Nagai,Y.,
            Yoshihara,K., Koga,K., Tateoka,T., Yoshioka,H., Shinozaki,Y.,
            Kinouchi,H., Tanaka,K.F., Bito,H., Tsuda,M. and Koizumi,S.
  TITLE     Disease-relevant upregulation of P2Y1 receptor in astrocytes
            enhances neuronal excitability via IGFBP2
  JOURNAL   Nat Commun 15 (1), 6525 (2024)
   PUBMED   39117630
  REMARK    GeneRIF: Disease-relevant upregulation of P2Y1 receptor in
            astrocytes enhances neuronal excitability via IGFBP2.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 158)
  AUTHORS   Kou,K., James,P.L., Clemmons,D.R., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Rotwein,P.
  TITLE     Identification of two clusters of mouse insulin-like growth factor
            binding protein genes on chromosomes 1 and 11
  JOURNAL   Genomics 21 (3), 653-655 (1994)
   PUBMED   7525452
REFERENCE   7  (residues 1 to 158)
  AUTHORS   Hahnel,A. and Schultz,G.A.
  TITLE     Insulin-like growth factor binding proteins are transcribed by
            preimplantation mouse embryos
  JOURNAL   Endocrinology 134 (4), 1956-1959 (1994)
   PUBMED   7511095
REFERENCE   8  (residues 1 to 158)
  AUTHORS   Hakeda,Y., Yoshizawa,K., Hurley,M., Kawaguchi,H., Tezuka,K.,
            Tanaka,K., Satoh,T. and Kumegawa,M.
  TITLE     Stimulatory effect of a phorbol ester on expression of insulin-like
            growth factor (IGF) binding protein-2 and level of IGF-I receptors
            in mouse osteoblastic MC3T3-E1 cells
  JOURNAL   J Cell Physiol 158 (3), 444-450 (1994)
   PUBMED   7510294
REFERENCE   9  (residues 1 to 158)
  AUTHORS   Donahue,L.R., Watson,G. and Beamer,W.G.
  TITLE     Regulation of metabolic water and protein compartments by
            insulin-like growth factor-I and testosterone in growth
            hormone-deficient lit/lit mice
  JOURNAL   J Endocrinol 139 (3), 431-439 (1993)
   PUBMED   7510770
REFERENCE   10 (residues 1 to 158)
  AUTHORS   Agarwal,N., Hsieh,C.L., Sills,D., Swaroop,M., Desai,B., Francke,U.
            and Swaroop,A.
  TITLE     Sequence analysis, expression and chromosomal localization of a
            gene, isolated from a subtracted human retina cDNA library, that
            encodes an insulin-like growth factor binding protein (IGFBP2)
  JOURNAL   Exp Eye Res 52 (5), 549-561 (1991)
   PUBMED   1712312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121498.12 and AC115870.18.
            
            On Jul 17, 2015 this sequence version replaced XP_006495770.1.
            
            Summary: The protein encoded by this gene is one of several similar
            proteins that bind insulin-like growth factors I and II (Igf-I and
            Igf-II). The encoded protein can be secreted into the bloodstream,
            where it binds Igf-I and Igf-II with high affinity, or it can
            remain intracellular, interacting with many different ligands. Two
            transcript variants, one encoding a secreted isoform and the other
            encoding a nonsecreted isoform, have been found for this gene.
            [provided by RefSeq, Sep 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.2250.1,
                                           SRR17253013.4130323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.94 cM"
     Protein         1..158
                     /product="insulin-like growth factor-binding protein 2
                     isoform 2"
                     /note="IGF-binding protein 2"
                     /calculated_mol_wt=17575
     Region          60..139
                     /region_name="Thyroglobulin_1"
                     /note="Thyroglobulin type-1 repeat; pfam00086"
                     /db_xref="CDD:459665"
     Site            order(64,89,107,115)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     CDS             1..158
                     /gene="Igfbp2"
                     /gene_synonym="IBP-2; Igfbp-2; mIGFBP-2"
                     /coded_by="NM_001310659.2:628..1104"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS78613.1"
                     /db_xref="GeneID:16008"
                     /db_xref="MGI:MGI:96437"
ORIGIN      
        1 mnmlgggssa grkplksgmk elavfrekvn eqhrqmgkga khlsleepkk lrpppartpc
       61 qqeldqvler istmrlpddr gplehlyslh ipncdkhgry nlkqckmsln gqrgecwcvn
      121 pntgkpiqga ptirgdpech lfyneqqetg gahaqsvq
//
LOCUS       NP_001344020             546 aa            linear   ROD 27-AUG-2025
DEFINITION  B-lymphocyte antigen CD19 isoform 2 precursor [Mus musculus].
ACCESSION   NP_001344020 XP_006507345
VERSION     NP_001344020.1
DBSOURCE    REFSEQ: accession NM_001357091.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 546)
  AUTHORS   Chen,R., Powell,J.S., Shufesky,W.J., Bardhi,E., Sullivan,M.L.G.,
            Tkacheva,O.A., Camirand,G., Goncalves,Z., Stolz,D.B., Chalasani,G.,
            Catz,S.D., Watkins,S.C., Larregina,A.T. and Morelli,A.E.
  TITLE     Transplants foster B cell alloimmunity by relaying extracellular
            vesicles to follicular dendritic cells
  JOURNAL   Cell Rep 44 (6), 115832 (2025)
   PUBMED   40516053
REFERENCE   2  (residues 1 to 546)
  AUTHORS   Kanayama,M., Izumi,Y., Onai,N., Akashi,T., Hiraoka,Y. and Ohteki,T.
  TITLE     Diverse developmental pathways of lymphoid conventional dendritic
            cells with distinct tissue distribution and function
  JOURNAL   Sci Adv 11 (23), eadt4909 (2025)
   PUBMED   40479074
REFERENCE   3  (residues 1 to 546)
  AUTHORS   Rompietti,C., Adamo,F.M., Sorcini,D., De Falco,F., Stella,A.,
            Martino,G., Bigerna,B., Dorillo,E., Silva Barcelos,E.C.,
            Esposito,A., Geraci,C., Arcaleni,R., Bordini,J., Scarfo,L.,
            Rosati,E., Ghia,P., Falini,B. and Sportoletti,P.
  TITLE     Bcor loss promotes Richter transformation of chronic lymphocytic
            leukemia associated with Notch1 activation in mice
  JOURNAL   Leukemia 39 (5), 1157-1168 (2025)
   PUBMED   40113912
REFERENCE   4  (residues 1 to 546)
  AUTHORS   Tracey,L.J., El-Maklizi,M., Sokolowski,D.J., Gams,M.S.,
            Brooke-Bisschop,T., Ruston,J., Taylor,C., Khozin,A.,
            Rajakumar,S.A., Wilson,M.D., Guidos,C.J. and Justice,M.J.
  TITLE     Functional and molecular single-cell analyses implicate PRDM14 in
            the initiation of B cell leukemia in mice
  JOURNAL   Sci Rep 15 (1), 8827 (2025)
   PUBMED   40087379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 546)
  AUTHORS   Zeng,Q., Guo,H., Tang,N., Renavikar,P.S., Karandikar,N.J.,
            Lovett-Racke,A.E., Racke,M.K., Yan,C., Tang,R., Sinha,S., Ghosh,K.,
            Ryal,J.P., Ouyang,S., Chen,M., Amari,F., Vincenzo,C., Pope,R.M.,
            Li,Y., Yang,H., Langdon,W.Y. and Zhang,J.
  TITLE     K27-linked RORgammat ubiquitination by Nedd4 potentiates
            Th17-mediated autoimmunity
  JOURNAL   J Biomed Sci 32 (1), 26 (2025)
   PUBMED   39972304
  REMARK    Erratum:[J Biomed Sci. 2025 Apr 16;32(1):42. doi:
            10.1186/s12929-025-01136-8. PMID: 40234865]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 546)
  AUTHORS   Kozmik,Z., Wang,S., Dorfler,P., Adams,B. and Busslinger,M.
  TITLE     The promoter of the CD19 gene is a target for the B-cell-specific
            transcription factor BSAP
  JOURNAL   Mol Cell Biol 12 (6), 2662-2672 (1992)
   PUBMED   1375324
REFERENCE   7  (residues 1 to 546)
  AUTHORS   Zhou,L.J., Ord,D.C., Omori,S.A. and Tedder,T.F.
  TITLE     Structure of the genes encoding the CD19 antigen of human and mouse
            B lymphocytes
  JOURNAL   Immunogenetics 35 (2), 102-111 (1992)
   PUBMED   1370948
REFERENCE   8  (residues 1 to 546)
  AUTHORS   Zhou,L.J., Ord,D.C., Hughes,A.L. and Tedder,T.F.
  TITLE     Structure and domain organization of the CD19 antigen of human,
            mouse, and guinea pig B lymphocytes. Conservation of the extensive
            cytoplasmic domain
  JOURNAL   J Immunol 147 (4), 1424-1432 (1991)
   PUBMED   1714482
REFERENCE   9  (residues 1 to 546)
  AUTHORS   Tedder,T.F. and Isaacs,C.M.
  TITLE     Isolation of cDNAs encoding the CD19 antigen of human and mouse B
            lymphocytes. A new member of the immunoglobulin superfamily
  JOURNAL   J Immunol 143 (2), 712-717 (1989)
   PUBMED   2472450
REFERENCE   10 (residues 1 to 546)
  AUTHORS   Nadler,L.M., Anderson,K.C., Marti,G., Bates,M., Park,E., Daley,J.F.
            and Schlossman,S.F.
  TITLE     B4, a human B lymphocyte-associated antigen expressed on normal,
            mitogen-activated, and malignant B lymphocytes
  JOURNAL   J Immunol 131 (1), 244-250 (1983)
   PUBMED   6408173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125322.4.
            
            On Oct 18, 2017 this sequence version replaced XP_006507345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156125.1, SRR5286960.52164.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     Protein         1..546
                     /product="B-lymphocyte antigen CD19 isoform 2 precursor"
                     /note="B-lymphocyte antigen CD19; differentiation antigen
                     CD19"
                     /calculated_mol_wt=58208
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1888
     Region          24..115
                     /region_name="CD19_protodomain_1_2"
                     /note="CD19 (Cluster of Differentiation 19), a unique
                     double immunoglobulin (Ig)-fold protodomain 1 and 2;
                     cd23999"
                     /db_xref="CDD:467826"
     Region          24..66
                     /region_name="protodomain 1"
                     /note="protodomain 1 [structural motif]"
                     /db_xref="CDD:467826"
     Region          24..29
                     /region_name="strand A'"
                     /note="strand A' [structural motif]"
                     /db_xref="CDD:467826"
     Region          31..38
                     /region_name="strand B"
                     /note="strand B [structural motif]"
                     /db_xref="CDD:467826"
     Site            order(33,35,37,81,83,85,111)
                     /site_type="other"
                     /note="CD81 binding site [polypeptide binding]"
                     /db_xref="CDD:467826"
     Region          39..48
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:467826"
     Region          48..55
                     /region_name="strand C"
                     /note="strand C [structural motif]"
                     /db_xref="CDD:467826"
     Site            56
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          62..66
                     /region_name="strand C'"
                     /note="strand C' [structural motif]"
                     /db_xref="CDD:467826"
     Region          67..70
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:467826"
     Region          70..115
                     /region_name="protodomain 2"
                     /note="protodomain 2 [structural motif]"
                     /db_xref="CDD:467826"
     Region          70..74
                     /region_name="strand D"
                     /note="strand D [structural motif]"
                     /db_xref="CDD:467826"
     Region          80..85
                     /region_name="strand E"
                     /note="strand E [structural motif]"
                     /db_xref="CDD:467826"
     Site            86
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          91..99
                     /region_name="strand F"
                     /note="strand F [structural motif]"
                     /db_xref="CDD:467826"
     Site            96
                     /site_type="other"
                     /note="antibody binding site [polypeptide binding]"
                     /db_xref="CDD:467826"
     Region          100..107
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:467826"
     Region          110..115
                     /region_name="strand G"
                     /note="strand G [structural motif]"
                     /db_xref="CDD:467826"
     Site            125
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Site            138
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Site            177
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          183..272
                     /region_name="CD19_double_Ig"
                     /note="CD19 (Cluster of Differentiation 19), a unique
                     double immunoglobulin (Ig)-fold domain; cl49627"
                     /db_xref="CDD:483967"
     Region          183..229
                     /region_name="protodomain 1+3"
                     /note="protodomain 1+3 [structural motif]"
                     /db_xref="CDD:467824"
     Region          183..188
                     /region_name="strand A'"
                     /note="strand A' [structural motif]"
                     /db_xref="CDD:467824"
     Region          190..197
                     /region_name="strand B"
                     /note="strand B [structural motif]"
                     /db_xref="CDD:467824"
     Site            order(192,194,196,229,243,245,247,252,268)
                     /site_type="other"
                     /note="CD81 binding site [polypeptide binding]"
                     /db_xref="CDD:467824"
     Region          198..207
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:467824"
     Region          207..214
                     /region_name="strand C"
                     /note="strand C [structural motif]"
                     /db_xref="CDD:467824"
     Site            order(214,258)
                     /site_type="other"
                     /note="antibody binding site [polypeptide binding]"
                     /db_xref="CDD:467824"
     Site            220
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          224..228
                     /region_name="strand C'"
                     /note="strand C' [structural motif]"
                     /db_xref="CDD:467824"
     Site            225
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15378723; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          229..236
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:467824"
     Region          236..272
                     /region_name="protodomain 2+4"
                     /note="protodomain 2+4 [structural motif]"
                     /db_xref="CDD:467824"
     Region          236..239
                     /region_name="strand D"
                     /note="strand D [structural motif]"
                     /db_xref="CDD:467824"
     Region          242..247
                     /region_name="strand E"
                     /note="strand E [structural motif]"
                     /db_xref="CDD:467824"
     Region          253..261
                     /region_name="strand F"
                     /note="strand F [structural motif]"
                     /db_xref="CDD:467824"
     Region          261..267
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:467824"
     Site            263
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          267..272
                     /region_name="strand G"
                     /note="strand G [structural motif]"
                     /db_xref="CDD:467824"
     Site            287..310
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25918.3)"
     Region          329..354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25918.3)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P15391; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          375..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25918.3)"
     Site            375
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P15391; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Site            401
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:20101619; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P15391; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          471..490
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25918.3)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:20101619,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     Region          504..546
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25918.3)"
     Site            521
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:20101619; propagated from
                     UniProtKB/Swiss-Prot (P25918.3)"
     CDS             1..546
                     /gene="Cd19"
                     /coded_by="NM_001357091.2:37..1677"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS90327.1"
                     /db_xref="GeneID:12478"
                     /db_xref="MGI:MGI:88319"
ORIGIN      
        1 mpsplpvsfl lfltlvggrp qksllvevee ggnvvlpclp dsspvssekl awyrgnqstp
       61 flelspgspg lglhvgslgi llvivnvsdh mggfylcqkr ppfkdiwqpa wtvnvedsge
      121 mfrwnasdvr dldcdlrnrs sgshrstsgs qlyvwakdhp kvwgtkpvca prgsslnqsl
      181 inqdltvapg stlwlscgvp pvpvakgsis wthvhprrpn vsllslslgg ehpvremwvw
      241 gsllllpqat aldegtyycl rgnltierhv kviarsvwlw llrtggwivp vvtlvyvifc
      301 mvslvaflyc qrafilrrkr krmtdparrf fkvtppsgng tqnqygnvls lptstsgqah
      361 aqrwaaglgs vpgsygnpri qvqdtgaqsh etgleeegea yeepdseegs efyendsnlg
      421 qdqvsqdgsg yenpedepmg peeedsfsna esyenadeel aqpvgrmmdf lsphgsawdp
      481 sreasslgsq syedmrgily aapqlhsiqs gpsheedads yenmdksddl epawegeghm
      541 gtwgtt
//
LOCUS       NP_001154904             297 aa            linear   ROD 27-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 27 [Mus
            musculus].
ACCESSION   NP_001154904
VERSION     NP_001154904.1
DBSOURCE    REFSEQ: accession NM_001161432.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 297)
  AUTHORS   Komic,J., Kelam,N., Racetin,A., Filipovic,N., Saraga-Babic,M.,
            Ihara,D., Katsuyama,Y. and Vukojevic,K.
  TITLE     Spatial and Temporal Expression Patterns of EDA2R, PCDH9, and TRAF7
            in Yotari (Dab1-/-) Mice: Implicationsfor Understanding CAKUT
            Pathogenesis
  JOURNAL   Int J Mol Sci 26 (13), 6421 (2025)
   PUBMED   40650197
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 297)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 297)
  AUTHORS   Guan,Z.H., Yang,D., Wang,Y., Ma,J.B. and Wang,G.N.
  TITLE     Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial
            ischemia/reperfusion injury through inhibiting the activation of
            the NF-kappaB signaling pathway
  JOURNAL   Exp Anim 73 (4), 376-389 (2024)
   PUBMED   38797667
  REMARK    GeneRIF: Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates
            myocardial ischemia/reperfusion injury through inhibiting the
            activation of the NF-kappaB signaling pathway.
REFERENCE   4  (residues 1 to 297)
  AUTHORS   Agca,S. and Kir,S.
  TITLE     EDA2R-NIK signaling in cancer cachexia
  JOURNAL   Curr Opin Support Palliat Care 18 (3), 126-131 (2024)
   PUBMED   38801457
  REMARK    GeneRIF: EDA2R-NIK signaling in cancer cachexia.
            Review article
REFERENCE   5  (residues 1 to 297)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   6  (residues 1 to 297)
  AUTHORS   Newton,K., French,D.M., Yan,M., Frantz,G.D. and Dixit,V.M.
  TITLE     Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR
            deficiency
  JOURNAL   Mol Cell Biol 24 (4), 1608-1613 (2004)
   PUBMED   14749376
  REMARK    GeneRIF: EDA-A2 transgenic mice exhibited multifocal
            myodegeneration; this phenotype was not observed in the absence of
            XEDAR
REFERENCE   7  (residues 1 to 297)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (residues 1 to 297)
  AUTHORS   Ruiz,S., Segrelles,C., Bravo,A., Santos,M., Perez,P., Leis,H.,
            Jorcano,J.L. and Paramio,J.M.
  TITLE     Abnormal epidermal differentiation and impaired
            epithelial-mesenchymal tissue interactions in mice lacking the
            retinoblastoma relatives p107 and p130
  JOURNAL   Development 130 (11), 2341-2353 (2003)
   PUBMED   12702649
REFERENCE   9  (residues 1 to 297)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 297)
  AUTHORS   Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
            Nishikawa,S. and Inoue,J.
  TITLE     TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
   PUBMED   12060722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732487.10.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106845.1, SRR11927934.477989.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 42.74 cM"
     Protein         1..297
                     /product="tumor necrosis factor receptor superfamily
                     member 27"
                     /note="X linked ectodysplasin receptor; EDA-A2 receptor;
                     X-linked ectodysplasin-A2 receptor"
                     /calculated_mol_wt=32935
     Region          2..41
                     /region_name="TNFR-Cys 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          3..118
                     /region_name="TNFRSF27"
                     /note="Tumor necrosis factor receptor superfamily member
                     27 (TNFRSF27), also known as ectodysplasin A2 receptor
                     (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR);
                     cd15838"
                     /db_xref="CDD:276934"
     Region          3..41
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276934"
     Region          43..83
                     /region_name="TNFR-Cys 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          44..83
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276934"
     Site            74
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BX35.1)"
     Site            77
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          85..118
                     /region_name="TNFR-Cys 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     Region          86..118
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276934"
     Site            139..159
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX35.1)"
     CDS             1..297
                     /gene="Eda2r"
                     /gene_synonym="9430060M22Rik; TNFRSF27; Xedar"
                     /coded_by="NM_001161432.2:234..1127"
                     /db_xref="CCDS:CCDS30293.1"
                     /db_xref="GeneID:245527"
                     /db_xref="MGI:MGI:2442860"
ORIGIN      
        1 mdcqeneyrd qwgrcvtcqq cgpgqelskd cgygeggdah civcpprkyk stwghhrcqt
       61 citcavinrv qkanctntsn aicgdclprf yrktrigglq dqecipctkq tpssevqctf
      121 qlslvkvdah tvppreatlv alvgsllvvf alaflglffl yckqifnrhc qcrdslqyea
      181 ektveedslf pvppgqetsp efpanegile ikplnsildd dcsstrgfpt qesftmasca
      241 seshsqwvht piecteldlq kfsssipstg petlrentae hsgdrlelyv pfevpsl
//
LOCUS       NP_001399544             206 aa            linear   ROD 27-AUG-2025
DEFINITION  synaptosomal-associated protein 25 isoform a [Mus musculus].
ACCESSION   NP_001399544
VERSION     NP_001399544.1
DBSOURCE    REFSEQ: accession NM_001412615.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Liu,W.W., Reicher,N., Alway,E., Rupprecht,L.E., Weng,P.,
            Schaefgen,C., Klein,M.E., Villalobos,J.A., Puerto-Hernandez,C.,
            Kiesling Altun,Y.G., Carbajal,A., Aguayo-Guerrero,J.A., Coss,A.,
            Sahasrabudhe,A., Anikeeva,P., de Araujo,A., Bali,A., de
            Lartigue,G., Gil-Lievana,E., Gutierrez,R., Miao,E.A., Rawls,J.F.,
            Kaelberer,M.M. and Bohorquez,D.V.
  TITLE     A gut sense for a microbial pattern regulates feeding
  JOURNAL   Nature (2025) In press
   PUBMED   40702192
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Forster,P.M., Jakob,M.O., Yusuf,D., Bubeck,M., Limberger,H.,
            Luo,Y., Thieme,P., Polici,A., Sterczyk,N., Boulekou,S., Bartel,L.,
            Cosovanu,C., Witkowski,M., Gonzalez-Acera,M., Kuhl,A.A.,
            Weidinger,C., Backofen,R., Hegazy,A.N., Patankar,J.V. and
            Klose,C.S.N.
  CONSRTM   TRR241 IBDome Consortium
  TITLE     A transcriptional atlas of gut-innervating neurons reveals
            activation of interferon signaling and ferroptosis during
            intestinal inflammation
  JOURNAL   Neuron 113 (9), 1333-1351 (2025)
   PUBMED   40101721
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Messore,L.F., Vadisiute,A., Edmead,H., Durmaz,A., Abuelem,M.,
            Chedotal,F., Hoerder-Suabedissen,A., Mann,E.O. and Molnar,Z.
  TITLE     Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven
            cortical activation
  JOURNAL   Front Neuroanat 19, 1548545 (2025)
   PUBMED   40357372
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Heiser,H., Kiessler,F., Roggenbach,A., Ibanez,V., Wieckhorst,M.,
            Helmchen,F., Gjorgjieva,J. and Wahl,A.S.
  TITLE     Brain-wide microstrokes affect the stability of memory circuits in
            the hippocampus
  JOURNAL   Nat Commun 16 (1), 3462 (2025)
   PUBMED   40216776
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 206)
  AUTHORS   DeSpenza,T. Jr., Kiziltug,E., Allington,G., Barson,D.G., McGee,S.,
            O'Connor,D., Robert,S.M., Mekbib,K.Y., Nanda,P., Greenberg,A.B.W.,
            Singh,A., Duy,P.Q., Mandino,F., Zhao,S., Lynn,A., Reeves,B.C.,
            Marlier,A., Getz,S.A., Nelson-Williams,C., Shimelis,H., Walsh,L.K.,
            Zhang,J., Wang,W., Prina,M.L., OuYang,A., Abdulkareem,A.F.,
            Smith,H., Shohfi,J., Mehta,N.H., Dennis,E., Reduron,L.R., Hong,J.,
            Butler,W., Carter,B.S., Deniz,E., Lake,E.M.R., Constable,R.T.,
            Sahin,M., Srivastava,S., Winden,K., Hoffman,E.J., Carlson,M.,
            Gunel,M., Lifton,R.P., Alper,S.L., Jin,S.C., Crair,M.C.,
            Moreno-De-Luca,A., Luikart,B.W. and Kahle,K.T.
  TITLE     PTEN mutations impair CSF dynamics and cortical networks by
            dysregulating periventricular neural progenitors
  JOURNAL   Nat Neurosci 28 (3), 536-557 (2025)
   PUBMED   39994410
REFERENCE   6  (residues 1 to 206)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   7  (residues 1 to 206)
  AUTHORS   Grimaldi,J.C., Torres,R., Kozak,C.A., Chang,R., Clark,E.A.,
            Howard,M. and Cockayne,D.A.
  TITLE     Genomic structure and chromosomal mapping of the murine CD40 gene
  JOURNAL   J Immunol 149 (12), 3921-3926 (1992)
   PUBMED   1281194
REFERENCE   8  (residues 1 to 206)
  AUTHORS   Hess,E.J., Jinnah,H.A., Kozak,C.A. and Wilson,M.C.
  TITLE     Spontaneous locomotor hyperactivity in a mouse mutant with a
            deletion including the Snap gene on chromosome 2
  JOURNAL   J Neurosci 12 (7), 2865-2874 (1992)
   PUBMED   1613559
REFERENCE   9  (residues 1 to 206)
  AUTHORS   Oyler,G.A., Polli,J.W., Wilson,M.C. and Billingsley,M.L.
  TITLE     Developmental expression of the 25-kDa synaptosomal-associated
            protein (SNAP-25) in rat brain
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5247-5251 (1991)
   PUBMED   1711221
REFERENCE   10 (residues 1 to 206)
  AUTHORS   Oyler,G.A., Higgins,G.A., Hart,R.A., Battenberg,E., Billingsley,M.,
            Bloom,F.E. and Wilson,M.C.
  TITLE     The identification of a novel synaptosomal-associated protein,
            SNAP-25, differentially expressed by neuronal subpopulations
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3039-3052 (1989)
   PUBMED   2592413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732447.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.957172.1,
                                           SRR17784643.1578463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.56 cM"
     Protein         1..206
                     /product="synaptosomal-associated protein 25 isoform a"
                     /note="super protein; synaptosomal-associated 25 kDa
                     protein; blind drunk; synaptosomal-associated protein, 25
                     kDa"
                     /calculated_mol_wt=23184
     Region          1..75
                     /region_name="Interaction with CENPF.
                     /evidence=ECO:0000269|PubMed:16672379"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Region          10..82
                     /region_name="SNARE_SNAP25N"
                     /note="N-terminal SNARE motif of SNAP25; cd15894"
                     /db_xref="CDD:277247"
     Site            order(24..25,28..29,31..33,35..40,42..44,46..47,49..50,
                     53..54,56..61,63..65,67..68,70..75,77..78)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277247"
     Site            53
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277247"
     Region          91..142
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          111..120
                     /region_name="Interaction with ZDHHC17.
                     /evidence=ECO:0000250|UniProtKB:P60880"
                     /note="propagated from UniProtKB/Swiss-Prot (P60879.1)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC and PKA.
                     /evidence=ECO:0000269|PubMed:12459461,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Region          143..201
                     /region_name="SNARE_SNAP25C"
                     /note="C-terminal SNARE motif of SNAP25; cd15885"
                     /db_xref="CDD:277238"
     Site            order(143,145..146,149..154,156..157,160..161,163..165,
                     167..168,171..172,174..175,177..182,184..185,188,191,195,
                     198,201)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277238"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            174
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277238"
     Site            180..181
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type E (BoNT/E).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:12459461; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     Site            197..198
                     /site_type="other"
                     /note="(Microbial infection) Cleavage, by C.botulinum
                     neurotoxin type A (BoNT/A, botA).
                     /evidence=ECO:0000269|PubMed:8243676,
                     ECO:0000305|PubMed:8103915; propagated from
                     UniProtKB/Swiss-Prot (P60879.1)"
     CDS             1..206
                     /gene="Snap25"
                     /gene_synonym="Bdr; GENA70; SNAP-25; sp; SUP"
                     /coded_by="NM_001412615.1:288..908"
                     /note="isoform a is encoded by transcript variant 6"
                     /db_xref="GeneID:20614"
                     /db_xref="MGI:MGI:98331"
ORIGIN      
        1 maedadmrne leemqrradq ladeslestr rmlqlveesk dagirtlvml deqgeqleri
       61 eegmdqinkd mkeaeknltd lgkfcglcvc pcnklkssda ykkawgnnqd gvvasqparv
      121 vdereqmais ggfirrvtnd arenemdenl eqvsgiignl rhmaldmgne idtqnrqidr
      181 imekadsnkt rideanqrat kmlgsg
//
LOCUS       NP_034703                480 aa            linear   ROD 27-AUG-2025
DEFINITION  iroquois-class homeodomain protein IRX-1 [Mus musculus].
ACCESSION   NP_034703 XP_127441
VERSION     NP_034703.2
DBSOURCE    REFSEQ: accession NM_010573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 480)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 480)
  AUTHORS   Santos-Cantador,J., Siguero-Alvarez,M. and de la Pompa,J.L.
  TITLE     Patterning Defects in Mice with Defective Ventricular Wall
            Maturation and Cardiomyopathy
  JOURNAL   J Cardiovasc Dev Dis 12 (6), 224 (2025)
   PUBMED   40558659
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 480)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   4  (residues 1 to 480)
  AUTHORS   Catela,C., Assimacopoulos,S., Chen,Y., Tsioras,K., Feng,W. and
            Kratsios,P.
  TITLE     The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets
            involved in motor neuron development
  JOURNAL   iScience 28 (4), 112210 (2025)
   PUBMED   40230530
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 480)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 480)
  AUTHORS   Christoffels,V.M., Keijser,A.G., Houweling,A.C., Clout,D.E. and
            Moorman,A.F.
  TITLE     Patterning the embryonic heart: identification of five mouse
            Iroquois homeobox genes in the developing heart
  JOURNAL   Dev Biol 224 (2), 263-274 (2000)
   PUBMED   10926765
REFERENCE   7  (residues 1 to 480)
  AUTHORS   Bosse,A., Stoykova,A., Nieselt-Struwe,K., Chowdhury,K.,
            Copeland,N.G., Jenkins,N.A. and Gruss,P.
  TITLE     Identification of a novel mouse Iroquois homeobox gene, Irx5, and
            chromosomal localisation of all members of the mouse Iroquois gene
            family
  JOURNAL   Dev Dyn 218 (1), 160-174 (2000)
   PUBMED   10822268
REFERENCE   8  (residues 1 to 480)
  AUTHORS   Cohen,D.R., Cheng,C.W., Cheng,S.H. and Hui,C.C.
  TITLE     Expression of two novel mouse Iroquois homeobox genes during
            neurogenesis
  JOURNAL   Mech Dev 91 (1-2), 317-321 (2000)
   PUBMED   10704856
REFERENCE   9  (residues 1 to 480)
  AUTHORS   Bosse,A., Zulch,A., Becker,M.B., Torres,M., Gomez-Skarmeta,J.L.,
            Modolell,J. and Gruss,P.
  TITLE     Identification of the vertebrate Iroquois homeobox gene family with
            overlapping expression during early development of the nervous
            system
  JOURNAL   Mech Dev 69 (1-2), 169-181 (1997)
   PUBMED   9486539
REFERENCE   10 (residues 1 to 480)
  AUTHORS   Ptacek,L.J., Tawil,R., Griggs,R.C., Meola,G., McManis,P.,
            Barohn,R.J., Mendell,J.R., Harris,C., Spitzer,R., Santiago,F. et
            al.
  TITLE     Sodium channel mutations in acetazolamide-responsive myotonia
            congenita, paramyotonia congenita, and hyperkalemic periodic
            paralysis
  JOURNAL   Neurology 44 (8), 1500-1503 (1994)
   PUBMED   8058156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133937.1, AW491133.1 and CO043226.1.
            
            On Mar 30, 2007 this sequence version replaced NP_034703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133937.1, AF165984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 38.43 cM"
     Protein         1..480
                     /product="iroquois-class homeodomain protein IRX-1"
                     /note="homeodomain protein IRXA1; iroquois homeobox
                     protein 1; Iroquois related homeobox 1"
                     /calculated_mol_wt=50038
     Region          146..184
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     Region          190..285
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     Region          <195..257
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P81068.4)"
     Region          309..326
                     /region_name="IRO"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; smart00548"
                     /db_xref="CDD:214716"
     Region          318..354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     Region          401..480
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     CDS             1..480
                     /gene="Irx1"
                     /coded_by="NM_010573.2:236..1678"
                     /db_xref="CCDS:CCDS26627.1"
                     /db_xref="GeneID:16371"
                     /db_xref="MGI:MGI:1197515"
ORIGIN      
        1 msfpqlgypq ylsaagpgay ggerpgvlaa aaaaaaaass grpgtaelga gagaaavtsv
       61 lgmyaaagpy agapnysafl pyaadlslfs qmgsqyelkd npgvhpatfa ahttpayypy
      121 gqfqygdpgr pknatrests tlkawlnehr knpyptkgek imlaiitkmt ltqvstwfan
      181 arrrlkkenk vtwgarskdq edgalfgsdt egdpekaedd eeidlesidi dqiderdgdq
      241 snedeedkae aprarvappa sardqsspls aaetlksqds plglvkevse pgstrllspg
      301 aaavglqgap hskpkiwsla etatspdgap kasppppssh asahgppsgs plqhpaflps
      361 hglytchigk fsnwtngafl aqgsllnmrs flgvsaphaa phgphltapp ppqppvqvat
      421 gvlhgekasa rsspalperd lvtrpdsppq qlkspfqpvr dnslapqegt prilaalpsa
//
LOCUS       NP_075945                 97 aa            linear   ROD 27-AUG-2025
DEFINITION  pro-neuropeptide Y preproprotein [Mus musculus].
ACCESSION   NP_075945
VERSION     NP_075945.1
DBSOURCE    REFSEQ: accession NM_023456.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 97)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 97)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 97)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   4  (residues 1 to 97)
  AUTHORS   Solheim,M.H., Stroganov,S., Chen,W., Subagia,P.S., Bauder,C.A.,
            Wnuk-Lipinski,D., Del Rio-Martin,A., Sotelo-Hitschfeld,T.,
            Beddows,C.A., Klemm,P., Dodd,G.T., Lundh,S., Secher,A.,
            Wunderlich,F.T., Steuernagel,L. and Bruning,J.C.
  TITLE     Hypothalamic PNOC/NPY neurons constitute mediators of
            leptin-controlled energy homeostasis
  JOURNAL   Cell 188 (13), 3550-3566 (2025)
   PUBMED   40273910
REFERENCE   5  (residues 1 to 97)
  AUTHORS   Kim,D.W., Duncan,L.H., Xu,Z., Chang,M., Sejer,S., Terrillion,C.E.,
            Kanold,P.O., Place,E. and Blackshaw,S.
  TITLE     Decoding gene networks controlling hypothalamic and prethalamic
            neuron development
  JOURNAL   Cell Rep 44 (6), 115858 (2025)
   PUBMED   40512619
REFERENCE   6  (residues 1 to 97)
  AUTHORS   Bahary,N., Pachter,J.E., Felman,R., Leibel,R.L., Albright,K.,
            Cram,S. and Friedman,J.M.
  TITLE     Molecular mapping of mouse chromosomes 4 and 6: use of a
            flow-sorted Robertsonian chromosome
  JOURNAL   Genomics 13 (3), 761-769 (1992)
   PUBMED   1639403
REFERENCE   7  (residues 1 to 97)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (residues 1 to 97)
  AUTHORS   Bahary,N., Zorich,G., Pachter,J.E., Leibel,R.L. and Friedman,J.M.
  TITLE     Molecular genetic linkage maps of mouse chromosomes 4 and 6
  JOURNAL   Genomics 11 (1), 33-47 (1991)
   PUBMED   1684952
REFERENCE   9  (residues 1 to 97)
  AUTHORS   Norman,D.J., Fletcher,C. and Heintz,N.
  TITLE     Genetic mapping of the lurcher locus on mouse chromosome 6 using an
            intersubspecific backcross
  JOURNAL   Genomics 9 (1), 147-153 (1991)
   PUBMED   1672287
REFERENCE   10 (residues 1 to 97)
  AUTHORS   Allen,J., Novotny,J., Martin,J. and Heinrich,G.
  TITLE     Molecular structure of mammalian neuropeptide Y: analysis by
            molecular cloning and computer-aided comparison with crystal
            structure of avian homologue
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2532-2536 (1987)
   PUBMED   3031687
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127376.3 and BC043012.1.
            
            Summary: This gene encodes a neuropeptide that plays a pivotal role
            in many physiological functions such as food intake, energy
            homeostasis, circadian rhythm, and cognition. The encoded protein
            precursor undergoes proteolytic processing to generate the
            biologically active peptide. Mice lacking the encoded protein
            exhibit mild seizures occasionally and become hyperphagic following
            food deprivation. A deficiency of the encoded protein partially
            prevents mice lacking leptin from becoming obese. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043012.1, CO040466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..97
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.04 cM"
     Protein         1..97
                     /product="pro-neuropeptide Y preproprotein"
                     /note="pro-neuropeptide Y"
                     /calculated_mol_wt=8031
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2861
     mat_peptide     29..64
                     /product="Neuropeptide Y. /id=PRO_0000025325"
                     /note="propagated from UniProtKB/Swiss-Prot (P57774.2)"
                     /calculated_mol_wt=4273
     Region          29..64
                     /region_name="PAH"
                     /note="Pancreatic hormones / neuropeptide F / peptide YY
                     family; smart00309"
                     /db_xref="CDD:197643"
     Site            30..31
                     /site_type="cleavage"
                     /note="Cleavage, by FAP.
                     /evidence=ECO:0000250|UniProtKB:P01303; propagated from
                     UniProtKB/Swiss-Prot (P57774.2)"
     Site            order(45,49,52,56,58..60)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238072"
     Site            order(48,52,55,59..61,63..64)
                     /site_type="active"
                     /note="receptor binding site [active]"
                     /db_xref="CDD:238072"
     Site            64
                     /site_type="amidation"
                     /note="Tyrosine amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P57774.2)"
     mat_peptide     68..97
                     /product="C-flanking peptide of NPY. /id=PRO_0000025326"
                     /note="propagated from UniProtKB/Swiss-Prot (P57774.2)"
                     /calculated_mol_wt=3435
     Region          75..97
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P57774.2)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P01303; propagated from
                     UniProtKB/Swiss-Prot (P57774.2)"
     CDS             1..97
                     /gene="Npy"
                     /gene_synonym="0710005A05Rik"
                     /coded_by="NM_023456.3:93..386"
                     /db_xref="CCDS:CCDS39488.1"
                     /db_xref="GeneID:109648"
                     /db_xref="MGI:MGI:97374"
ORIGIN      
        1 mlgnkrmglc gltlalsllv clgilaegyp skpdnpgeda paedmaryys alrhyinlit
       61 rqrygkrssp etlisdllmk estenaprtr ledpsmw
//
LOCUS       NP_033886                421 aa            linear   ROD 27-AUG-2025
DEFINITION  bone morphogenetic protein 10 preproprotein [Mus musculus].
ACCESSION   NP_033886
VERSION     NP_033886.2
DBSOURCE    REFSEQ: accession NM_009756.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Leonard,R., Zhao,Y., Eliason,S., Zimmerman,K., Batz,A.,
            Hatcher,C.J., Weiss,R.M., Sweat,M., Li,X. and Amendt,B.A.
  TITLE     Single-nuclei multiomics analysis identifies abnormal
            cardiomyocytes in a murine model of cardiac development
  JOURNAL   Nat Commun 16 (1), 6947 (2025)
   PUBMED   40721580
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Santos-Cantador,J., Siguero-Alvarez,M. and de la Pompa,J.L.
  TITLE     Patterning Defects in Mice with Defective Ventricular Wall
            Maturation and Cardiomyopathy
  JOURNAL   J Cardiovasc Dev Dis 12 (6), 224 (2025)
   PUBMED   40558659
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   4  (residues 1 to 421)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   5  (residues 1 to 421)
  AUTHORS   Fiore,R., Rahim,B., Christoffels,V.M., Moorman,A.F. and
            Puschel,A.W.
  TITLE     Inactivation of the Sema5a gene results in embryonic lethality and
            defective remodeling of the cranial vascular system
  JOURNAL   Mol Cell Biol 25 (6), 2310-2319 (2005)
   PUBMED   15743826
  REMARK    Erratum:[Mol Cell Biol. 2020 Sep 28;40(20):e00409-20. doi:
            10.1128/MCB.00409-20. PMID: 32989048]
REFERENCE   6  (residues 1 to 421)
  AUTHORS   Kang,J.O. and Sucov,H.M.
  TITLE     Convergent proliferative response and divergent morphogenic
            pathways induced by epicardial and endocardial signaling in fetal
            heart development
  JOURNAL   Mech Dev 122 (1), 57-65 (2005)
   PUBMED   15582777
REFERENCE   7  (residues 1 to 421)
  AUTHORS   Lickert,H., Takeuchi,J.K., Von Both,I., Walls,J.R., McAuliffe,F.,
            Adamson,S.L., Henkelman,R.M., Wrana,J.L., Rossant,J. and
            Bruneau,B.G.
  TITLE     Baf60c is essential for function of BAF chromatin remodelling
            complexes in heart development
  JOURNAL   Nature 432 (7013), 107-112 (2004)
   PUBMED   15525990
REFERENCE   8  (residues 1 to 421)
  AUTHORS   Chen,H., Shi,S., Acosta,L., Li,W., Lu,J., Bao,S., Chen,Z., Yang,Z.,
            Schneider,M.D., Chien,K.R., Conway,S.J., Yoder,M.C., Haneline,L.S.,
            Franco,D. and Shou,W.
  TITLE     BMP10 is essential for maintaining cardiac growth during murine
            cardiogenesis
  JOURNAL   Development 131 (9), 2219-2231 (2004)
   PUBMED   15073151
  REMARK    GeneRIF: Results describe an essential role of bone morphogenetic
            protein 10 in regulating cardiac growth and chamber maturation.
REFERENCE   9  (residues 1 to 421)
  AUTHORS   Gaussin,V., Van de Putte,T., Mishina,Y., Hanks,M.C., Zwijsen,A.,
            Huylebroeck,D., Behringer,R.R. and Schneider,M.D.
  TITLE     Endocardial cushion and myocardial defects after cardiac
            myocyte-specific conditional deletion of the bone morphogenetic
            protein receptor ALK3
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 2878-2883 (2002)
   PUBMED   11854453
REFERENCE   10 (residues 1 to 421)
  AUTHORS   Neuhaus,H., Rosen,V. and Thies,R.S.
  TITLE     Heart specific expression of mouse BMP-10 a novel member of the
            TGF-beta superfamily
  JOURNAL   Mech Dev 80 (2), 181-184 (1999)
   PUBMED   10072785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155726.4 and BC145983.1.
            
            On Oct 3, 2007 this sequence version replaced NP_033886.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate the mature protein, which
            binds to the activin receptor-like kinase 1 (ALK1) and plays
            important roles in cardiovascular development including
            cardiomyocyte proliferation and regulation of heart size, closure
            of the ductus arteriosus, angiogenesis and ventricular
            trabeculation. Homozygous knockout mice for this gene exhibit
            impaired heart development and embryonic lethality. [provided by
            RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145983.1, BY000749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.96 cM"
     Protein         1..421
                     /product="bone morphogenetic protein 10 preproprotein"
                     /note="BMP-10"
                     /calculated_mol_wt=45847
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2059
     Region          55..230
                     /region_name="TGFb_propeptide"
                     /note="TGF-beta propeptide; cl46657"
                     /db_xref="CDD:480997"
     Site            67
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R229.2)"
     Site            131
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R229.2)"
     mat_peptide     314..421
                     /product="Bone morphogenetic protein 10.
                     /id=PRO_0000033891"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R229.2)"
                     /calculated_mol_wt=12118
     Region          318..421
                     /region_name="TGF_beta_BMP10"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in bone morphogenetic protein 10 (BMP-10) and
                     similar proteins; cd19401"
                     /db_xref="CDD:381671"
     Site            order(325,327,331..332,334,344,346..348,365..366,369..370,
                     372..373,376,380..382,385,387..388,391,411..413,415,421)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381671"
     CDS             1..421
                     /gene="Bmp10"
                     /gene_synonym="b2b2711Clo"
                     /coded_by="NM_009756.3:40..1305"
                     /db_xref="CCDS:CCDS51838.1"
                     /db_xref="GeneID:12154"
                     /db_xref="MGI:MGI:1338820"
ORIGIN      
        1 mgslvlplsa vfclvahsas gspimgleqs pleedmpffd difteqdgid fntllqsmkn
       61 eflktlnlsd ipvqdtgrvd ppeymlelyn kfatdrtsmp saniirsfkn edlfsqpvtf
      121 nglrkypllf nvsiphheev vmaelrlytl vqrdrmmydg vdrkitifev lesadgseee
      181 rsmlvlvste iygtnsewet fdvtdatrrw qksgpsthql eihiesrqnq aedtgrgqle
      241 idmsaqnkhd pllvvfsddq sndkeqkeel nelitheqdl dldsdaffsg pdeeallqmr
      301 snmiddssar irrnakgnyc kktplyidfk eigwdswiia ppgyeayecr gvcnyplaeh
      361 ltptkhaiiq alvhlknsqk askaccvptk ldpisilyld kgvvtykfky egmavsecgc
      421 r
//
LOCUS       NP_001407284             373 aa            linear   ROD 27-AUG-2025
DEFINITION  LIM/homeobox protein Lhx2 isoform d [Mus musculus].
ACCESSION   NP_001407284 XP_006497797
VERSION     NP_001407284.1
DBSOURCE    REFSEQ: accession NM_001420355.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Shen,X., Anirudhan,J., Fatima,A., Plant,E., Szemes,T., Bouveret,Z.,
            Keruzore,M., Kricha,S., Nan,X., Sabate San Jose,A., Bianchin,S.,
            Veraghen,B., Delhaye,L.P., Mian,B.A., Khalid,L.B., Ali,F.,
            Zahra,H., Ali,A., Toft,M., Dieu,M., Achouri,Y., Li,M., Renard,P.,
            Van Lint,C., Poulard,C., Iqbal,Z. and Bellefroid,E.J.
  TITLE     Evidence That Dmrta2 Acts through Repression of Pax6 in Cortical
            Patterning and Identification of a Mutation Impairing DNA
            Recognition Associated with Microcephaly in Human
  JOURNAL   eNeuro 12 (6) (2025)
   PUBMED   40541527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   6  (residues 1 to 373)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 373)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 373)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 373)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 373)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            On May 2, 2023 this sequence version replaced XP_006497797.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2065856.1,
                                           SRR10662774.2557680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..373
                     /product="LIM/homeobox protein Lhx2 isoform d"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=40691
     Region          2..65
                     /region_name="LIM1_Lhx2"
                     /note="The first LIM domain of Lhx2; cd09469"
                     /db_xref="CDD:188853"
     Site            order(12,15,33,36,39,42,61,64)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188853"
     Region          78..136
                     /region_name="LIM2_Lhx2_Lhx9"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     cd09377"
                     /db_xref="CDD:188763"
     Site            order(82,85,104,107,110,113,132,135)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188763"
     Region          <214..345
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          234..290
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..373
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001420355.1:540..1661"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mpsissdraa lcagcggkis dryyllavdk qwhmrclkcc ecklnlesel tcfskdgsiy
       61 ckedyyspsl hgphrrfsvq rcarchlgis asemvmrard lvyhlncftc ttcnkmlttg
      121 dhfgmkdslv ycrlhfeall qgeypahfnh advaaaaaaa aaaksaglgs aganplglpy
      181 yngvgtvqkg rprkrkspgp gadlaaynaa lscnendaeh ldrdqpypss qktkrmrtsf
      241 khhqlrtmks yfainhnpda kdlkqlaqkt gltkrvlqvw fqnarakfrr nllrqentgv
      301 dktsdatlqt gtpsgpasel snaslspsst pttltdltsp tlptvtsvlt svpgnleghe
      361 phspsqttlt nlf
//
LOCUS       NP_033985                306 aa            linear   ROD 27-AUG-2025
DEFINITION  T-lymphocyte activation antigen CD80 precursor [Mus musculus].
ACCESSION   NP_033985
VERSION     NP_033985.3
DBSOURCE    REFSEQ: accession NM_009855.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 306)
  AUTHORS   Jaggi,U. and Ghiasi,H.
  TITLE     Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency
  JOURNAL   Viruses 16 (9), 1379 (2024)
   PUBMED   39339855
  REMARK    GeneRIF: Presence of CD80 and Absence of LAT in Modulating Cellular
            Infiltration and HSV-1 Latency.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 306)
  AUTHORS   Luan,J., Truong,C., Vuchkovska,A., Guo,W., Good,J., Liu,B.,
            Gang,A., Infarinato,N., Stewart,K., Polak,L., Pasolli,H.A.,
            Andretta,E., Rudensky,A.Y., Fuchs,E. and Miao,Y.
  TITLE     CD80 on skin stem cells promotes local expansion of regulatory T
            cells upon injury to orchestrate repair within an inflammatory
            environment
  JOURNAL   Immunity 57 (5), 1071-1086 (2024)
   PUBMED   38677291
  REMARK    GeneRIF: CD80 on skin stem cells promotes local expansion of
            regulatory T cells upon injury to orchestrate repair within an
            inflammatory environment.
REFERENCE   3  (residues 1 to 306)
  AUTHORS   Alugupalli,K.R.
  TITLE     Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity
            of Multivalent Meningococcal Polysaccharide Conjugate Vaccines
  JOURNAL   Immunohorizons 8 (4), 317-325 (2024)
   PUBMED   38625118
REFERENCE   4  (residues 1 to 306)
  AUTHORS   Jaggi,U., Matundan,H.H., Oh,J.J. and Ghiasi,H.
  TITLE     Absence of CD80 reduces HSV-1 replication in the eye and delays
            reactivation but not latency levels
  JOURNAL   J Virol 98 (3), e0201023 (2024)
   PUBMED   38376148
  REMARK    GeneRIF: Absence of CD80 reduces HSV-1 replication in the eye and
            delays reactivation but not latency levels.
REFERENCE   5  (residues 1 to 306)
  AUTHORS   Subileau,M. and Vittet,D.
  TITLE     Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 7 (2023)
   PUBMED   38054922
REFERENCE   6  (residues 1 to 306)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (residues 1 to 306)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
REFERENCE   8  (residues 1 to 306)
  AUTHORS   Larsen,C.P., Ritchie,S.C., Pearson,T.C., Linsley,P.S. and
            Lowry,R.P.
  TITLE     Functional expression of the costimulatory molecule, B7/BB1, on
            murine dendritic cell populations
  JOURNAL   J Exp Med 176 (4), 1215-1220 (1992)
   PUBMED   1328465
REFERENCE   9  (residues 1 to 306)
  AUTHORS   Razi-Wolf,Z., Freeman,G.J., Galvin,F., Benacerraf,B., Nadler,L. and
            Reiser,H.
  TITLE     Expression and function of the murine B7 antigen, the major
            costimulatory molecule expressed by peritoneal exudate cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 4210-4214 (1992)
   PUBMED   1373896
REFERENCE   10 (residues 1 to 306)
  AUTHORS   Selvakumar,A., Mohanraj,B.K., Eddy,R.L., Shows,T.B., White,P.C. and
            Dupont,B.
  TITLE     Genomic organization and chromosomal location of the human gene
            encoding the B-lymphocyte activation antigen B7
  JOURNAL   Immunogenetics 36 (3), 175-181 (1992)
   PUBMED   1377173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X60958.1 and AC154425.2.
            
            On Aug 23, 2006 this sequence version replaced NP_033985.2.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on its better conservation in mammalian
            species, a strong Kozak signal and on a higher probability of an
            N-terminal signal peptide being present in the resulting protein.
            An upstream in-frame start codon is also present but has a weaker
            Kozak signal and is only present in mouse; use of the upstream
            start codon would result in a protein that is 8 aa longer at the
            N-terminus. Leaky scanning by ribosomes may allow translation
            initiation at the downstream start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60958.1, AF065893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.86 cM"
     Protein         1..306
                     /product="T-lymphocyte activation antigen CD80 precursor"
                     /note="B7 protein; activation B7-1 antigen"
                     /calculated_mol_wt=30387
     sig_peptide     1..37
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
                     /calculated_mol_wt=4221
     mat_peptide     37..306
                     /product="T-lymphocyte activation antigen CD80"
                     /calculated_mol_wt=30502
     mat_peptide     38..306
                     /product="T-lymphocyte activation antigen CD80.
                     /id=PRO_0000014548"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
                     /calculated_mol_wt=30387
     Region          39..142
                     /region_name="IgV_CD80"
                     /note="Immunoglobulin variable domain (IgV) in Cluster of
                     Differentiation (CD) 80; cd16086"
                     /db_xref="CDD:319335"
     Region          39..54
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:319335"
     Region          40..45
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:319335"
     Region          49..55
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:319335"
     Region          55..64
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:319335"
     Site            order(60,63,80,85,96,98..100,105,107)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319335"
     Region          65..72
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:319335"
     Region          65..71
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:319335"
     Site            order(67,69,71,74,76,85,99,120,122,129..131)
                     /site_type="other"
                     /note="B7-1/CTLA-4 complex [polypeptide binding]"
                     /db_xref="CDD:319335"
     Region          72..91
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:319335"
     Region          76..81
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:319335"
     Region          84..87
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:319335"
     Region          92..124
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:319335"
     Site            93
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          94..100
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:319335"
     Site            99
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          102..107
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:319335"
     Region          115..125
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:319335"
     Region          125..128
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:319335"
     Region          128..142
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:319335"
     Region          129..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:319335"
     Region          145..235
                     /region_name="IgC1_CD80"
                     /note="Immunoglobulin constant (IgC)-like domain of
                     antigen receptor Cluster of Differentiation (CD) 80;
                     member of the C1-set of Ig superfamily (IgSF) domains;
                     cd16083"
                     /db_xref="CDD:409505"
     Region          148..154
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409505"
     Site            149
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          160..168
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409505"
     Site            order(171,197..200)
                     /site_type="other"
                     /note="intrachain IgC domain interface [polypeptide
                     binding]"
                     /db_xref="CDD:409505"
     Region          174..180
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409505"
     Region          182..184
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409505"
     Region          189..196
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409505"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          200..210
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409505"
     Site            210
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          214..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409505"
     Site            214
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q00609.1)"
     Region          226..235
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409505"
     Region          227..246
                     /region_name="Ig-hinge-like. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
     Site            247..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00609.1)"
     CDS             1..306
                     /gene="Cd80"
                     /gene_synonym="B71; Cd28l; Ly-53; Ly53; MIC17; TSA1"
                     /coded_by="NM_009855.2:249..1169"
                     /db_xref="CCDS:CCDS28168.1"
                     /db_xref="GeneID:12519"
                     /db_xref="MGI:MGI:101775"
ORIGIN      
        1 macncqlmqd tpllkfpcpr lillfvllir lsqvssdvde qlsksvkdkv llpcrynsph
       61 edesedriyw qkhdkvvlsv iagklkvwpe yknrtlydnt tysliilglv lsdrgtyscv
      121 vqkkergtye vkhlalvkls ikadfstpni tesgnpsadt kritcfasgg fpkprfswle
      181 ngrelpgint tisqdpesel ytissqldfn ttrnhtikcl ikygdahvse dftwekpped
      241 ppdskntlvl fgagfgavit vvvivviikc fckhrscfrr neasretnns ltfgpeeala
      301 eqtvfl
//
LOCUS       NP_001415302             236 aa            linear   ROD 27-AUG-2025
DEFINITION  autophagy protein 5 isoform 4 [Mus musculus].
ACCESSION   NP_001415302
VERSION     NP_001415302.1
DBSOURCE    REFSEQ: accession NM_001428373.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 236)
  AUTHORS   Jiang,Z., Baechler,B.L., Li,H., Lad,H., Ciavarra,G., Ben-David,Y.,
            Burden,S.J., Quadrilatero,J. and Zacksenhaus,E.
  TITLE     The tumor suppressor pRb and its relative p130 are required to
            maintain murine adult skeletal muscle homeostasis
  JOURNAL   Oncogene 44 (30), 2662-2674 (2025)
   PUBMED   40640334
REFERENCE   2  (residues 1 to 236)
  AUTHORS   Kochlamazashvili,G., Swaminathan,A., Stumpf,A., Kumar,A., Posor,Y.,
            Schmitz,D., Haucke,V. and Kuijpers,M.
  TITLE     Neuronal autophagy controls excitability via ryanodine
            receptor-mediated regulation of calcium-activated potassium channel
            function
  JOURNAL   Proc Natl Acad Sci U S A 122 (17), e2413651122 (2025)
   PUBMED   40267139
REFERENCE   3  (residues 1 to 236)
  AUTHORS   Wang,X., Li,Y., Li,Y., Wang,X., Song,H., Wang,Y., Huang,C., Mao,C.,
            Wang,L., Zhong,C., Yu,D., Xia,Z., Feng,Y., Duan,J., Liu,Y., Ou,J.,
            Luo,C., Mai,W., Hong,H., Cai,W., Zheng,L., Trempe,J.F., Fon,E.A.,
            Liao,J., Yi,W. and Chen,J.
  TITLE     AMPK-dependent Parkin activation suppresses macrophage antigen
            presentation to promote tumor progression
  JOURNAL   Sci Adv 11 (12), eadn8402 (2025)
   PUBMED   40117357
REFERENCE   4  (residues 1 to 236)
  AUTHORS   Song,Y., Li,N., Jiang,S., Wang,K., Lv,G., Fan,Z., Du,X., Gao,W.,
            Lei,L., Wang,Z., Liu,G. and Li,X.
  TITLE     Microbiota-derived H2S induces c-kit+ cDC1 autophagic cell death
            and liver inflammation in metabolic dysfunction-associated
            steatohepatitis
  JOURNAL   Nat Commun 16 (1), 2222 (2025)
   PUBMED   40044736
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 236)
  AUTHORS   Tutas,J., Tolve,M., Ozer-Yildiz,E., Ickert,L., Klein,I.,
            Silverman,Q., Liebsch,F., Dethloff,F., Giavalisco,P., Endepols,H.,
            Georgomanolis,T., Neumaier,B., Drzezga,A., Schwarz,G., Thorens,B.,
            Gatto,G., Frezza,C. and Kononenko,N.L.
  TITLE     Autophagy regulator ATG5 preserves cerebellar function by
            safeguarding its glycolytic activity
  JOURNAL   Nat Metab 7 (2), 297-320 (2025)
   PUBMED   39815080
REFERENCE   6  (residues 1 to 236)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (residues 1 to 236)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (residues 1 to 236)
  AUTHORS   Mizushima,N., Yamamoto,A., Hatano,M., Kobayashi,Y., Kabeya,Y.,
            Suzuki,K., Tokuhisa,T., Ohsumi,Y. and Yoshimori,T.
  TITLE     Dissection of autophagosome formation using Apg5-deficient mouse
            embryonic stem cells
  JOURNAL   J Cell Biol 152 (4), 657-668 (2001)
   PUBMED   11266458
REFERENCE   9  (residues 1 to 236)
  AUTHORS   Pires-DaSilva,A. and Gruss,P.
  TITLE     Gene trap insertion into a novel gene expressed during mouse limb
            development
  JOURNAL   Dev Dyn 212 (2), 318-325 (1998)
   PUBMED   9626506
REFERENCE   10 (residues 1 to 236)
  AUTHORS   Hammond,E.M., Brunet,C.L., Johnson,G.D., Parkhill,J., Milner,A.E.,
            Brady,G., Gregory,C.D. and Grand,R.J.
  TITLE     Homology between a human apoptosis specific protein and the product
            of APG5, a gene involved in autophagy in yeast
  JOURNAL   FEBS Lett 425 (3), 391-395 (1998)
   PUBMED   9563500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155642.6.
            
            Summary: The protein encoded by this gene, in combination with
            autophagy protein 12, functions as an E1-like activating enzyme in
            a ubiquitin-like conjugating system. The encoded protein is
            involved in several cellular processes, including autophagic
            vesicle formation, mitochondrial quality control after oxidative
            damage, negative regulation of the innate antiviral immune
            response, lymphocyte development and proliferation, MHC II antigen
            presentation, adipocyte differentiation, and apoptosis. Two
            transcript variants encoding different protein isoforms have been
            found for this gene. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.133139.1,
                                           SRR13422601.358385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..236
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.24 cM"
     Protein         1..236
                     /product="autophagy protein 5 isoform 4"
                     /note="autophagy protein 5"
                     /calculated_mol_wt=27372
     Region          79..>189
                     /region_name="APG5"
                     /note="Autophagy protein Apg5; pfam04106"
                     /db_xref="CDD:461175"
     CDS             1..236
                     /gene="Atg5"
                     /gene_synonym="2010107M05Rik; 3110067M24Rik; Apg5l; Atg5l;
                     Paddy"
                     /coded_by="NM_001428373.1:244..954"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /db_xref="GeneID:11793"
                     /db_xref="MGI:MGI:1277186"
ORIGIN      
        1 mtddkdvlrd vwfgriptcf tlyqdeiter eaepyylllp rvsyltlvtd kvkkhfqkvm
       61 rqedvseiwf eyegtplkwh ypigllfdll asssalpwni tvhfksfpek dllhcpskda
      121 veahfmscmk eadalkhksq vinemqkkdh kqlwmglqnd ltsfgpstgn swnilqkkmd
      181 fvispleyir prrsglssrs csglwpqmds cthleissek svlpqsplkm errgar
//
LOCUS       NP_062786                737 aa            linear   ROD 27-AUG-2025
DEFINITION  NAD-dependent protein deacetylase sirtuin-1 isoform 1 [Mus
            musculus].
ACCESSION   NP_062786 XP_910902
VERSION     NP_062786.1
DBSOURCE    REFSEQ: accession NM_019812.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 737)
  AUTHORS   Hu,C., Geng,J., Shan,P., Zhang,T., Zhang,Z., Zhang,X., Lin,M.,
            Zhang,X., Chang,D., He,B., Jia,D., Zhang,M., Wang,C. and Zhang,S.
  TITLE     Deacetylation of nuclear AIF provides a braking mechanism for
            caspase-independent chromatinolysis and necrotic brain injury
  JOURNAL   Commun Biol 8 (1), 813 (2025)
   PUBMED   40425818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 737)
  AUTHORS   Zhao,Y., Wang,Y., Zheng,H., Xu,Q., Zhou,K., Liu,H., Xia,Y.,
            Wei,D.H., Jiang,M., Tang,Z.H., Liu,L.S., Zheng,H. and Jiang,Z.
  TITLE     Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced
            endothelial cell damage and mitochondrial dysfunction
  JOURNAL   Nitric Oxide 152, 78-89 (2024)
   PUBMED   39305980
  REMARK    GeneRIF: Hydrogen sulfide upregulates SIRT1 to inhibit
            ox-HDL-induced endothelial cell damage and mitochondrial
            dysfunction.
REFERENCE   3  (residues 1 to 737)
  AUTHORS   de Lima,J., Leite,J.A., Basso,P.J., Ghirotto,B., Martins da
            Silva,E., Menezes-Silva,L., Hiyane,M.I., Goes,C.P., Coutinho,L.L.,
            de Andrade Oliveira,V. and Olsen Saraiva Camara,N.
  TITLE     Sirtuin 1 regulates the phenotype and functions of dendritic cells
            through Ido1 pathway in obesity
  JOURNAL   Cell Death Dis 15 (10), 757 (2024)
   PUBMED   39424786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 737)
  AUTHORS   Nevoral,J., Drutovic,D., Vaskovicova,M., Benc,M., Liska,F.,
            Valentova,I., Stachovicova,S., Kubovciak,J., Havrankova,J.,
            Shavit,M., Monsef,L., Iniesta-Cuerda,M., Zalmanova,T., Hosek,P.,
            Strejcek,F., Kralickova,M. and Petr,J.
  TITLE     Dynamics and necessity of SIRT1 for maternal-zygotic transition
  JOURNAL   Sci Rep 14 (1), 21598 (2024)
   PUBMED   39285243
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 737)
  AUTHORS   Wu,L., Zhang,S., Zhang,M., Ou,Y. and Chen,J.
  TITLE     Occlusal disharmony promotes anxiety-like behaviours by suppressing
            Sirt1
  JOURNAL   Clin Oral Investig 28 (10), 526 (2024)
   PUBMED   39276172
  REMARK    GeneRIF: Occlusal disharmony promotes anxiety-like behaviours by
            suppressing Sirt1.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 737)
  AUTHORS   Giblin,W., Skinner,M.E. and Lombard,D.B.
  TITLE     Sirtuins: guardians of mammalian healthspan
  JOURNAL   Trends Genet 30 (7), 271-286 (2014)
   PUBMED   24877878
  REMARK    Review article
REFERENCE   7  (residues 1 to 737)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
  REMARK    GeneRIF: Sirt1(Sir2alpha) deacetylates p53 and promotes survival
REFERENCE   8  (residues 1 to 737)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   9  (residues 1 to 737)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   10 (residues 1 to 737)
  AUTHORS   Imai,S., Armstrong,C.M., Kaeberlein,M. and Guarente,L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153516.8, AK140330.1,
            BE989110.1, BX523319.1, AK139946.1 and AK141245.1.
            
            On Dec 7, 2005 this sequence version replaced XP_910902.1.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, characterized by their deacetylase activity and proposed
            role in longevity. The encoded protein regulates gene expression in
            a wide range of cell and tissue types through its NAD+-dependent
            deacetylation of histones, transcription factors and
            transcriptional coactivators. Brain-specific overexpression of this
            gene has been shown to result in increased median lifespan.
            Viability of homozygous knockout mice for this gene varies with
            strain background. Homozygous knockout mice of strains that do not
            exhibit embryonic lethality are sterile and have a reduced
            lifespan. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY377984.1, AF214646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     Protein         1..737
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform 1"
                     /EC_number="2.3.1.286"
                     /note="SIR2-like protein 1; sirtuin 1 ((silent mating type
                     information regulation 2, homolog) 1; regulatory protein
                     SIR2 homolog 1; NAD-dependent protein deacetylase
                     sirtuin-1; NAD-dependent protein deacylase sirtuin-1"
                     /calculated_mol_wt=80241
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     mat_peptide     2..525
                     /product="SirtT1 75 kDa fragment.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6.
                     /id=PRO_0000415290"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
                     /calculated_mol_wt=57116
     Region          2..268
                     /region_name="Interaction with H1-4.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          2..131
                     /region_name="Interaction with CLOCK.
                     /evidence=ECO:0000269|PubMed:18662547"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          32..39
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK8.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          75..125
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          135..533
                     /region_name="Interaction with CCAR2.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          138..145
                     /region_name="Nuclear export signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          152..171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          223..230
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            230
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:28923965; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          246..481
                     /region_name="SIRT1"
                     /note="Eukaryotic group (class1) which includes human
                     sirtuins SIRT1-3 and yeast Hst1-4; and are members of the
                     SIR2 family of proteins, silent information regulator 2
                     (Sir2) enzymes which catalyze NAD+-dependent
                     protein/histone deacetylation. Sir2 proteins...; cd01408"
                     /db_xref="CDD:238699"
     Region          248..251
                     /region_name="Required for interaction with the sumoylated
                     form of CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            order(255,257..258,265..266,319,337..338,340,355,432,437,
                     458..459,473)
                     /site_type="other"
                     /note="NAD+ binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(339,355,404,406..410,436..438)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238699"
     Site            order(363,366,387,390)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238699"
     Site            369
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:28923965; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            422
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000305|PubMed:28923965; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          425..431
                     /region_name="Nuclear export signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            505
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000305|PubMed:28923965; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          514..539
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by DYRK1A, DYRK3 and MAPK8.
                     /evidence=ECO:0000269|PubMed:20167603; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            536
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            600
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000305|PubMed:28923965; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            649
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2.
                     /evidence=ECO:0000269|PubMed:19680552; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            651
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     Region          653..713
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923E4.2)"
     Site            737
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96EB6; propagated from
                     UniProtKB/Swiss-Prot (Q923E4.2)"
     CDS             1..737
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /coded_by="NM_019812.3:66..2279"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23898.1"
                     /db_xref="GeneID:93759"
                     /db_xref="MGI:MGI:2135607"
ORIGIN      
        1 madevalalq aagspsaaaa meaasqpade plrkrprrdg pglgrspgep saavapaaag
       61 ceaasaaapa alwreaagaa asaereapat avagdgdngs glrrepraad dfdddegeee
      121 deaaaaaaaa aigyrdnlll tdglltngfh scesddddrt shasssdwtp rprigpytfv
      181 qqhlmigtdp rtilkdllpe tipppelddm tlwqivinil seppkrkkrk dintiedavk
      241 llqeckkiiv ltgagvsvsc gipdfrsrdg iyarlavdfp dlpdpqamfd ieyfrkdprp
      301 ffkfakeiyp gqfqpslchk fialsdkegk llrnytqnid tleqvagiqr ilqchgsfat
      361 asclickykv dceavrgdif nqvvprcprc padeplaimk peivffgenl peqfhramky
      421 dkdevdlliv igsslkvrpv alipssiphe vpqilinrep lphlhfdvel lgdcdviine
      481 lchrlggeya klccnpvkls eitekpprpq kelvhlselp ptplhiseds sspertvpqd
      541 ssviatlvdq atnnnvndle vsesscveek pqevqtsrnv eninvenpdf kavgsstadk
      601 nertsvaetv rkcwpnrlak eqiskrlegn qylfvppnry ifhgaevysd seddvlssss
      661 cgsnsdsgtc qspsleeple deseieefyn gleddterpe caggsgfgad ggdqevvnea
      721 iatrqeltdv nypsdks
//
LOCUS       NP_663757                526 aa            linear   ROD 27-AUG-2025
DEFINITION  thymocyte selection-associated high mobility group box protein TOX
            [Mus musculus].
ACCESSION   NP_663757 XP_910430 XP_924344 XP_924358 XP_924367 XP_924376
            XP_924386 XP_924399
VERSION     NP_663757.3
DBSOURCE    REFSEQ: accession NM_145711.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Huang,Y.J., Ngiow,S.F., Baxter,A.E., Manne,S., Park,S.L., Wu,J.E.,
            Khan,O., Giles,J.R. and Wherry,E.J.
  TITLE     Continuous expression of TOX safeguards exhausted CD8 T cell
            epigenetic fate
  JOURNAL   Sci Immunol 10 (105), eado3032 (2025)
   PUBMED   40053604
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Bao,K., Gu,X., Song,Y., Zhou,Y., Chen,Y., Yu,X., Yuan,W., Shi,L.,
            Zheng,J. and Hong,M.
  TITLE     TCF-1 and TOX regulate the memory formation of intestinal group 2
            innate lymphoid cells in asthma
  JOURNAL   Nat Commun 15 (1), 7850 (2024)
   PUBMED   39245681
  REMARK    GeneRIF: TCF-1 and TOX regulate the memory formation of intestinal
            group 2 innate lymphoid cells in asthma.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Das,A., Martinez-Ruiz,G.U., Bouladoux,N., Stacy,A., Moraly,J.,
            Vega-Sendino,M., Zhao,Y., Lavaert,M., Ding,Y., Morales-Sanchez,A.,
            Harly,C., Seedhom,M.O., Chari,R., Awasthi,P., Ikeuchi,T., Wang,Y.,
            Zhu,J., Moutsopoulos,N.M., Chen,W., Yewdell,J.W., Shapiro,V.S.,
            Ruiz,S., Taylor,N., Belkaid,Y. and Bhandoola,A.
  TITLE     Transcription factor Tox2 is required for metabolic adaptation and
            tissue residency of ILC3 in the gut
  JOURNAL   Immunity 57 (5), 1019-1036 (2024)
   PUBMED   38677292
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Laz,E.V., Holloway,M.G., Chen,C.S. and Waxman,D.J.
  TITLE     Characterization of three growth hormone-responsive transcription
            factors preferentially expressed in adult female liver
  JOURNAL   Endocrinology 148 (7), 3327-3337 (2007)
   PUBMED   17412818
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   9  (residues 1 to 526)
  AUTHORS   O'Flaherty,E. and Kaye,J.
  TITLE     TOX defines a conserved subfamily of HMG-box proteins
  JOURNAL   BMC Genomics 4 (1), 13 (2003)
   PUBMED   12697058
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671871.4 and AL831740.9.
            
            On Dec 2, 2008 this sequence version replaced NP_663757.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All 3 variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080732.1, AK133397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 3.04 cM"
     Protein         1..526
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /note="thymus high mobility group box protein TOX;
                     thymocyte selection-associated HMG box"
                     /calculated_mol_wt=57072
     Region          194..264
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JW3.2)"
     Region          237..256
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JW3.2)"
     Region          262..331
                     /region_name="HMG-box_TOX-like"
                     /note="high mobility group (HMG)-box found in the TOX high
                     mobility group box family; cd21995"
                     /db_xref="CDD:438811"
     Site            order(262..263,265..269,272..273,280,292..293,296,
                     299..300,307,311,314,318,321)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438811"
     CDS             1..526
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /coded_by="NM_145711.5:346..1926"
                     /db_xref="CCDS:CCDS17953.1"
                     /db_xref="GeneID:252838"
                     /db_xref="MGI:MGI:2181659"
ORIGIN      
        1 mdvrfypppa qpaaapaapc lgpspcldpy ycnkfdgenm ymsmtepsqd yvpasqsypg
       61 pslesedfni ppitppslpd hslvhlneve sgyhslchpm nhngllpfhp qtmdlpeitv
      121 snmlgqdgal lsnsisvmqe ignaegaqys shpqmaamrp rgqptdirqq asmmqpgqlt
      181 tinqsqlsaq lglnmggtnv ahnspsppgs ksatpspsss vhedecedas kinggekrpa
      241 sdmgkkpktp kkkkkkdpne pqkpvsayal ffrdtqaaik gqnpnatfge vskivasmwd
      301 glgeeqkqvy kkkteaakke ylkqlaayra slvsksytdp vdvktsqppq lvnskpsvfh
      361 gpsqahsaly lsshyhqqpg mtpqltamhp slprniapkp nnqmpvtvsi anmavspppp
      421 lqispplhqh lsmqqhqsla mqqplgsqlp mqvqtalhsp tmqqgftlqp dyqtiinpts
      481 taaqvvtqam eyvrsgcrnp ppqpvdwstd ycssggmqrd kalylt
//
LOCUS       NP_056559                862 aa            linear   ROD 27-AUG-2025
DEFINITION  autotaxin isoform 2 preproprotein [Mus musculus].
ACCESSION   NP_056559
VERSION     NP_056559.2
DBSOURCE    REFSEQ: accession NM_015744.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 862)
  AUTHORS   Arroyo-Ataz,G., Yague,A.C., Breda,J.C., Mazzilli,S.A. and Jones,D.
  TITLE     Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in
            Lymphatic Muscle and Venous Smooth Muscle Development, Identity,
            and Function
  JOURNAL   Arterioscler Thromb Vasc Biol 45 (7), 1207-1225 (2025)
   PUBMED   40371470
REFERENCE   2  (residues 1 to 862)
  AUTHORS   Dacheux,M.A., Norman,D.D., Shin,Y., Tigyi,G.J. and Lee,S.C.
  TITLE     Deleting autotaxin in LysM+ myeloid cells impairs innate tumor
            immunity in models of metastatic melanoma
  JOURNAL   iScience 27 (10), 110971 (2024)
   PUBMED   39398245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 862)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   4  (residues 1 to 862)
  AUTHORS   Petersen-Cherubini,C.L., Liu,Y., Deffenbaugh,J.L., Murphy,S.P.,
            Xin,M., Rau,C.N., Yang,Y. and Lovett-Racke,A.E.
  TITLE     Dysregulated autotaxin expression by T cells in multiple sclerosis
  JOURNAL   J Neuroimmunol 387, 578282 (2024)
   PUBMED   38183947
  REMARK    GeneRIF: Dysregulated autotaxin expression by T cells in multiple
            sclerosis.
REFERENCE   5  (residues 1 to 862)
  AUTHORS   Giganti,A., Rodriguez,M., Fould,B., Moulharat,N., Coge,F.,
            Chomarat,P., Galizzi,J.P., Valet,P., Saulnier-Blache,J.S.,
            Boutin,J.A. and Ferry,G.
  TITLE     Murine and human autotaxin alpha, beta, and gamma isoforms: gene
            organization, tissue distribution, and biochemical characterization
  JOURNAL   J Biol Chem 283 (12), 7776-7789 (2008)
   PUBMED   18175805
  REMARK    GeneRIF: Murine and human autotaxin alpha, beta, and gamma
            isoforms: gene organization, tissue distribution, and biochemical
            characterization.
REFERENCE   6  (residues 1 to 862)
  AUTHORS   Koike,S., Keino-Masu,K., Ohto,T. and Masu,M.
  TITLE     The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions
            as a signal peptide
  JOURNAL   Genes Cells 11 (2), 133-142 (2006)
   PUBMED   16436050
REFERENCE   7  (residues 1 to 862)
  AUTHORS   Jansen,S., Stefan,C., Creemers,J.W., Waelkens,E., Van Eynde,A.,
            Stalmans,W. and Bollen,M.
  TITLE     Proteolytic maturation and activation of autotaxin (NPP2), a
            secreted metastasis-enhancing lysophospholipase D
  JOURNAL   J Cell Sci 118 (Pt 14), 3081-3089 (2005)
   PUBMED   15985467
REFERENCE   8  (residues 1 to 862)
  AUTHORS   Bachner,D., Ahrens,M., Betat,N., Schroder,D. and Gross,G.
  TITLE     Developmental expression analysis of murine autotaxin (ATX)
  JOURNAL   Mech Dev 84 (1-2), 121-125 (1999)
   PUBMED   10473125
REFERENCE   9  (residues 1 to 862)
  AUTHORS   Bachner,D., Ahrens,M., Schroder,D., Hoffmann,A., Lauber,J.,
            Betat,N., Steinert,P., Flohe,L. and Gross,G.
  TITLE     Bmp-2 downstream targets in mesenchymal development identified by
            subtractive cloning from recombinant mesenchymal progenitors
            (C3H10T1/2)
  JOURNAL   Dev Dyn 213 (4), 398-411 (1998)
   PUBMED   9853961
REFERENCE   10 (residues 1 to 862)
  AUTHORS   Narita,M., Goji,J., Nakamura,H. and Sano,K.
  TITLE     Molecular cloning, expression, and localization of a brain-specific
            phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from
            rat brain
  JOURNAL   J Biol Chem 269 (45), 28235-28242 (1994)
   PUBMED   7961762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY123373.1, AK161144.1 and
            CD741437.1.
            
            On Feb 22, 2008 this sequence version replaced NP_056559.1.
            
            Summary: This gene encodes a member of the phosphodiesterase and
            nucleotide pyrophosphatase family of bifunctional enzymes that
            hydrolize phosphodiester bonds of various nucleotides. The encoded
            protein undergoes proteolytic processing to generate a mature
            protein with lysophospholipase D activity, catalyzing the cleavage
            of the choline group from lysophosphatidylcholine to produce
            lysophosphatidic acid. This gene is expressed in numerous tissues
            and participates in neural development, obesity, inflammation and
            oncogenesis. A complete lack of the encoded protein in mice results
            in aberrant vascular and neuronal development leading to embryonic
            lethality. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (2, also known as beta) lacks an
            in-frame exon in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF123542.1, SRR1660811.112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.6 cM"
     Protein         1..862
                     /product="autotaxin isoform 2 preproprotein"
                     /EC_number="3.1.4.4"
                     /EC_number="3.1.4.39"
                     /note="ectonucleotide pyrophosphatase/phosphodiesterase
                     family member 2; autotaxin; extracellular
                     lysophospholipase D; phosphodiesterase I/nucleotide
                     pyrophosphatase 2"
                     /calculated_mol_wt=96008
     sig_peptide     1..27
                     /note="/evidence=ECO:0000250|UniProtKB:Q64610; propagated
                     from UniProtKB/Swiss-Prot (Q9R1E6.3)"
                     /calculated_mol_wt=2896
     mat_peptide     36..862
                     /product="Autotaxin. /id=PRO_0000188568"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
                     /calculated_mol_wt=95047
     Site            53
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0007744|PDB:3NKM,
                     ECO:0007744|PDB:3NKN, ECO:0007744|PDB:3NKO,
                     ECO:0007744|PDB:3NKP, ECO:0007744|PDB:3NKQ,
                     ECO:0007744|PDB:3NKR, ECO:0007744|PDB:3WAV,
                     ECO:0007744|PDB:3WAW, ECO:0007744|PDB:3WAX,
                     ECO:0007744|PDB:3WAY, ECO:0007744|PDB:5INH; propagated
                     from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          56..97
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          98..141
                     /region_name="SO"
                     /note="Somatomedin B -like domains; smart00201"
                     /db_xref="CDD:197571"
     Region          126..128
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          144..501
                     /region_name="Phosphodiesterase domain.
                     /evidence=ECO:0000305|PubMed:21240269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          165..477
                     /region_name="Phosphodiest"
                     /note="Type I phosphodiesterase / nucleotide
                     pyrophosphatase; pfam01663"
                     /db_xref="CDD:396300"
     Site            order(171,208..209,230,311,315,358..359,474)
                     /site_type="active"
                     /db_xref="CDD:293742"
     Site            order(171,208..209,230,311,315,359,474)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293742"
     Site            410
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639,
                     ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN,
                     ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP,
                     ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR,
                     ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW,
                     ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY,
                     ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH,
                     ECO:0007744|PDB:5LIA; propagated from UniProtKB/Swiss-Prot
                     (Q9R1E6.3)"
     Site            499..501
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:293742"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21240269,
                     ECO:0000269|PubMed:23688339, ECO:0000269|PubMed:27780639,
                     ECO:0007744|PDB:3NKM, ECO:0007744|PDB:3NKN,
                     ECO:0007744|PDB:3NKO, ECO:0007744|PDB:3NKP,
                     ECO:0007744|PDB:3NKQ, ECO:0007744|PDB:3NKR,
                     ECO:0007744|PDB:3WAV, ECO:0007744|PDB:3WAW,
                     ECO:0007744|PDB:3WAX, ECO:0007744|PDB:3WAY,
                     ECO:0007744|PDB:5HRT, ECO:0007744|PDB:5INH,
                     ECO:0007744|PDB:5LIA; propagated from UniProtKB/Swiss-Prot
                     (Q9R1E6.3)"
     Region          597..862
                     /region_name="Nuclease-like domain.
                     /evidence=ECO:0000305|PubMed:21240269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          614..844
                     /region_name="NUC"
                     /note="DNA/RNA non-specific endonuclease; smart00477"
                     /db_xref="CDD:214683"
     Site            order(676..677,679,716,720)
                     /site_type="active"
                     /db_xref="CDD:238043"
     Site            order(676..677,720)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:238043"
     Site            806
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Region          829..850
                     /region_name="Required for secretion.
                     /evidence=ECO:0000269|PubMed:19329427"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1E6.3)"
     Site            852
                     /site_type="other"
                     /note="Essential for catalytic activity.
                     /evidence=ECO:0000269|PubMed:19329427; propagated from
                     UniProtKB/Swiss-Prot (Q9R1E6.3)"
     CDS             1..862
                     /gene="Enpp2"
                     /gene_synonym="ATX; E-NPP 2; lysoPLD; Npps2; PD-Ialpha;
                     Pdnp2"
                     /coded_by="NM_015744.4:186..2774"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS27472.1"
                     /db_xref="GeneID:18606"
                     /db_xref="MGI:MGI:1321390"
ORIGIN      
        1 marqgcfgsy qvislftfai gvnlclgfta srikraewde gpptvlsdsp wtntsgsckg
       61 rcfelqevgp pdcrcdnlck sysscchdfd elclktargw ectkdrcgev rneenachcs
      121 edclsrgdcc tnyqvvckge shwvdddcee irvpecpagf vrppliifsv dgfrasymkk
      181 gskvmpniek lrscgthapy mrpvyptktf pnlytlatgl ypeshgivgn smydpvfdat
      241 fhlrgrekfn hrwwggqplw itatkqgvra gtffwsvsip herriltilq wlslpdnerp
      301 svyafyseqp dfsghkygpf gpemtnplre idktvgqlmd glkqlklhrc vnvifvgdhg
      361 medvtcdrte flsnyltnvd ditlvpgtlg rirpkipnnl kydpkaiian ltckkpdqhf
      421 kpymkqhlpk rlhyannrri edlhllverr whvarkpldv ykkpsgkcff qgdhgfdnkv
      481 nsmqtvfvgy gptfkyrtkv ppfenielyn vmcdllglkp apnngthgsl nhllrtntfr
      541 ptlpeevsrp nypgimylqs dfdlgctcdd kvepknklee lnkrlhtkgs teerhllygr
      601 pavlyrtsyd ilyhtdfesg yseiflmplw tsytiskqae vssipehltn cvrpdvrvsp
      661 gfsqnclayk ndkqmsygfl fppylssspe akydaflvtn mvpmypafkr vwtyfqrvlv
      721 kkyaserngv nvisgpifdy nynglrdied eikqyvegss ipvpthyysi itscldftqp
      781 adkcdgplsv ssfilphrpd ndescnssed eskwveelmk mhtarvrdie hltgldfyrk
      841 tsrsyseilt lktylhtyes ei
//
LOCUS       NP_001277686            1050 aa            linear   ROD 27-AUG-2025
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_001277686 XP_006528777
VERSION     NP_001277686.1
DBSOURCE    REFSEQ: accession NM_001290757.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Rasile,M., Sommariva,M., Menegola,E., Di Renzo,F., Anselmi,M.,
            Sfondrini,L., Barajon,I. and Arnaboldi,F.
  TITLE     TLR7 expression patterns in mouse eye development and adult ocular
            tissues
  JOURNAL   Int J Dev Biol 69 (2), 101-107 (2025)
   PUBMED   40521682
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Sato,R., Liu,K., Shibata,T., Hoshino,K., Yamaguchi,K., Miyazaki,T.,
            Hiranuma,R., Fukui,R., Motoi,Y., Fukuda-Ohta,Y., Zhang,Y.,
            Reuter,T., Ishida,Y., Kondo,T., Chiba,T., Asahara,H., Taoka,M.,
            Yamauchi,Y., Isobe,T., Kaisho,T., Furukawa,Y., Latz,E.,
            Nakatani,K., Izumi,Y., Nie,Y., Taniguchi,H. and Miyake,K.
  TITLE     RNase T2 deficiency promotes TLR13-dependent replenishment of
            tissue-protective Kupffer cells
  JOURNAL   J Exp Med 222 (3) (2025)
   PUBMED   39853307
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Greene,T.T., Jo,Y., Chiale,C., Macal,M., Fang,Z., Khatri,F.S.,
            Codrington,A.L., Kazane,K.R., Akbulut,E., Swaminathan,S.,
            Fujita,Y., Fitzgerald-Bocarsly,P., Cordes,T., Metallo,C.,
            Scott,D.A. and Zuniga,E.I.
  TITLE     Metabolic deficiencies underlie reduced plasmacytoid dendritic cell
            IFN-I production following viral infection
  JOURNAL   Nat Commun 16 (1), 1460 (2025)
   PUBMED   39920132
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Yang,Y., Treger,R.S., Hernandez-Bird,J., Lu,P., Mao,T. and
            Iwasaki,A.
  TITLE     A B cell screen against endogenous retroviruses identifies
            glycan-reactive IgM that recognizes a broad array of enveloped
            viruses
  JOURNAL   Sci Immunol 9 (101), eadd6608 (2024)
   PUBMED   39514636
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Wang,C., Khatun,M.S., Ellsworth,C.R., Chen,Z., Islamuddin,M.,
            Nisperuza Vidal,A.K., Afaque Alam,M., Liu,S., Mccombs,J.E.,
            Maness,N.J., Blair,R.V., Kolls,J.K. and Qin,X.
  TITLE     Deficiency of Tlr7 and Irf7 in mice increases the severity of
            COVID-19 through the reduced interferon production
  JOURNAL   Commun Biol 7 (1), 1162 (2024)
   PUBMED   39289468
  REMARK    GeneRIF: Deficiency of Tlr7 and Irf7 in mice increases the severity
            of COVID-19 through the reduced interferon production.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil,F., Hemmi,H., Hochrein,H., Ampenberger,F., Kirschning,C.,
            Akira,S., Lipford,G., Wagner,H. and Bauer,S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold,S.S., Kaisho,T., Hemmi,H., Akira,S. and Reis e Sousa,C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield,G., Ramanathan,M., Hasko,G., Vogel,S.N.,
            Salzman,A.L., Boons,G.J. and Leibovich,S.J.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi,H., Kaisho,T., Takeuchi,O., Sato,S., Sanjo,H., Hoshino,K.,
            Horiuchi,T., Tomizawa,H., Takeda,K. and Akira,S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006528777.1.
            
            Transcript Variant: This variant (4) lacks two alternate exons and
            uses an alternate splice site in the 5' region, and initiates
            translation from an alternate upstream start codon, compared to
            variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156908.1, AF334943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3187
     mat_peptide     27..1050
                     /product="Toll-like receptor 7. /id=PRO_0000034734"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=118668
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          484..>786
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_001290757.1:268..3420"
                     /note="isoform a precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS30531.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_001032836             536 aa            linear   ROD 27-AUG-2025
DEFINITION  caspase recruitment domain-containing protein 9 [Mus musculus].
ACCESSION   NP_001032836 XP_285326 XP_919952
VERSION     NP_001032836.1
DBSOURCE    REFSEQ: accession NM_001037747.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Qiu,D., Zhang,S., Huang,C., Wang,X., Deng,J., Sun,H., Feng,B.,
            Tan,Y., Ji,K., Xu,S., Ye,X., Cheng,C., Kakuta,S., Adachi,Y.,
            Iwakura,Y., Wang,S., Dong,S. and Tang,C.
  TITLE     Dectin-1 facilitates lung fungal-mediated pulmonary fibrosis
  JOURNAL   Immunity 58 (7), 1811-1829 (2025)
   PUBMED   40494347
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Mills,K.A.M., Westermann,F., Espinosa,V., Rosiek,E., Desai,J.V.,
            Aufiero,M.A., Guo,Y., Liu,F.L., Mitchell,K.A., Tuzlak,S., De
            Feo,D., Lionakis,M.S., Rivera,A., Becher,B. and Hohl,T.M.
  TITLE     GM-CSF-mediated epithelial-immune cell cross-talk orchestrates
            pulmonary immunity to Aspergillus fumigatus
  JOURNAL   Sci Immunol 10 (105), eadr0547 (2025)
   PUBMED   40117345
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Linnemann,L., Antwi-Ekwuruke,J., Gnanapragassam,V., Bang,C.,
            Ruhlemann,M., Ruland,J., Hartmann,W., Heepmann,L., Dorken,S.,
            Yunus,S.M., Viebrock,B., Schlosser,A., Lepenies,B. and Breloer,M.
  TITLE     The C-type lectin receptor MINCLE interferes with eosinophil
            function and protective intestinal immunity in Strongyloides
            ratti-infected mice
  JOURNAL   Mucosal Immunol 18 (1), 220-231 (2025)
   PUBMED   39581231
REFERENCE   4  (residues 1 to 536)
  AUTHORS   Wang,R., Oliveira,L.V.N., Hester,M.M., Carlson,D., Christensen,D.,
            Specht,C.A. and Levitz,S.M.
  TITLE     Protection against experimental cryptococcosis elicited by Cationic
            Adjuvant Formulation 01-adjuvanted subunit vaccines
  JOURNAL   PLoS Pathog 20 (7), e1012220 (2024)
   PUBMED   38976694
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 536)
  AUTHORS   Danne,C., Lamas,B., Lavelle,A., Michel,M.L., Da Costa,G.,
            Pham,H.P., Lefevre,A., Bridonneau,C., Bredon,M., Planchais,J.,
            Straube,M., Emond,P., Langella,P. and Sokol,H.
  TITLE     Dissecting the respective roles of microbiota and host genetics in
            the susceptibility of Card9-/- mice to colitis
  JOURNAL   Microbiome 12 (1), 76 (2024)
   PUBMED   38649950
  REMARK    GeneRIF: Dissecting the respective roles of microbiota and host
            genetics in the susceptibility of Card9[-/-] mice to colitis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 536)
  AUTHORS   Gross,O., Grupp,C., Steinberg,C., Zimmermann,S., Strasser,D.,
            Hannesschlager,N., Reindl,W., Jonsson,H., Huo,H., Littman,D.R.,
            Peschel,C., Yokoyama,W.M., Krug,A. and Ruland,J.
  TITLE     Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1
            complex via Carma1 for NF-kappaB and MAPK activation to selectively
            control cytokine production
  JOURNAL   Blood 112 (6), 2421-2428 (2008)
   PUBMED   18192506
REFERENCE   7  (residues 1 to 536)
  AUTHORS   Hara,H., Ishihara,C., Takeuchi,A., Imanishi,T., Xue,L.,
            Morris,S.W., Inui,M., Takai,T., Shibuya,A., Saijo,S., Iwakura,Y.,
            Ohno,N., Koseki,H., Yoshida,H., Penninger,J.M. and Saito,T.
  TITLE     The adaptor protein CARD9 is essential for the activation of
            myeloid cells through ITAM-associated and Toll-like receptors
  JOURNAL   Nat Immunol 8 (6), 619-629 (2007)
   PUBMED   17486093
  REMARK    GeneRIF: activation of lymphoid and myeloid cells through
            Immunoreceptor tyrosine-based activation motifs-associated
            receptors or Toll-like receptors is regulated by CARMA1-Bcl-10 and
            CARD9-Bcl-10, respectively
REFERENCE   8  (residues 1 to 536)
  AUTHORS   LeibundGut-Landmann,S., Gross,O., Robinson,M.J., Osorio,F.,
            Slack,E.C., Tsoni,S.V., Schweighoffer,E., Tybulewicz,V.,
            Brown,G.D., Ruland,J. and Reis e Sousa,C.
  TITLE     Syk- and CARD9-dependent coupling of innate immunity to the
            induction of T helper cells that produce interleukin 17
  JOURNAL   Nat Immunol 8 (6), 630-638 (2007)
   PUBMED   17450144
  REMARK    GeneRIF: signaling through Syk and CARD9 can couple innate to
            adaptive immunity independently of Toll-like receptor signals
REFERENCE   9  (residues 1 to 536)
  AUTHORS   Hsu,Y.M., Zhang,Y., You,Y., Wang,D., Li,H., Duramad,O., Qin,X.F.,
            Dong,C. and Lin,X.
  TITLE     The adaptor protein CARD9 is required for innate immune responses
            to intracellular pathogens
  JOURNAL   Nat Immunol 8 (2), 198-205 (2007)
   PUBMED   17187069
  REMARK    GeneRIF: CARD9 has a critical function in Nod2-mediated activation
            of p38 and Jnk in innate immune responses to intracellular
            pathogens
REFERENCE   10 (residues 1 to 536)
  AUTHORS   Gross,O., Gewies,A., Finger,K., Schafer,M., Sparwasser,T.,
            Peschel,C., Forster,I. and Ruland,J.
  TITLE     Card9 controls a non-TLR signalling pathway for innate anti-fungal
            immunity
  JOURNAL   Nature 442 (7103), 651-656 (2006)
   PUBMED   16862125
  REMARK    GeneRIF: Card9 is a key transducer of Dectin-1 signalling, where
            Dectin-1 is the major mammalian pattern recognition receptor for
            the fungal component zymosan, in antifungal immunity
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732541.11.
            
            On or before Jul 25, 2007 this sequence version replaced
            XP_919952.1, XP_285326.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1710886.1,
                                           SRR7345562.1720195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.87 cM"
     Protein         1..536
                     /product="caspase recruitment domain-containing protein 9"
                     /calculated_mol_wt=62331
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPY0; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Region          10..95
                     /region_name="CARD_CARD9"
                     /note="Caspase activation and recruitment domain of
                     CARD9-like proteins; cd08809"
                     /db_xref="CDD:260071"
     Site            order(23,26,29,60)
                     /site_type="other"
                     /note="putative BCL10 interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:260071"
     Region          99..116
                     /region_name="Linker.
                     /evidence=ECO:0000250|UniProtKB:Q9H257"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AIV8.1)"
     Region          <154..>417
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCD.
                     /evidence=ECO:0000269|PubMed:22265677; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H257; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPY0; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Region          425..451
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            425
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H257; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            451
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9EPY0; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            461
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Region          476..536
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            483
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H257; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            498
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H257; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            531
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q9EPY0; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     Site            533
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q9EPY0; propagated from
                     UniProtKB/Swiss-Prot (A2AIV8.1)"
     CDS             1..536
                     /gene="Card9"
                     /gene_synonym="Gm782"
                     /coded_by="NM_001037747.3:136..1746"
                     /db_xref="CCDS:CCDS38084.1"
                     /db_xref="GeneID:332579"
                     /db_xref="MGI:MGI:2685628"
ORIGIN      
        1 msdyenddec wstlesfrvk lisvidpsri tpylrqckvl npddeeqvls dpnlvirkrk
       61 vgvlldilqr tghkgyvafl eslelyypql yrkvtgkepa rvfsmiidas gesgltqllm
      121 tevmklqkkv qdltallssk ddfikelrvk dsllrkhqer vqrlkeecel ssaelkrckd
      181 enyelamcla hlseekgaal mrnrdlqlev drlrhslmka eddckverkh tlklrhameq
      241 rpsqellwel qqekdllqar vqelqvsvqe gkldrnspyi qvleedwrqa lqehqkqvst
      301 ifslrkdlrq aetlrarcte ekemfelqcl alrkdakmyk drieaillqm eevsierdqa
      361 masreelhaq ctqsfqdkdk lrklvrelge kadelqlqlf qtesrllaae grlkqqqldm
      421 lilssdleds sprnsqelsl pqdleedaql sdkgvladre speqpfmaln kehlslthgm
      481 gpssseppek errrlkesfe nyrrkralrk mqnswrqgeg drgnttgsdn tdtegs
//
LOCUS       NP_038674                523 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform 1 [Mus musculus].
ACCESSION   NP_038674 XP_489717
VERSION     NP_038674.1
DBSOURCE    REFSEQ: accession NM_013646.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 523)
  AUTHORS   Naef,P., Jaeger-Ruckstuhl,C.A., Schnuriger,N., Forster,S.,
            Monteiro,I., Brigger,D., Eggel,A., Kessenbrock,K., Riether,C. and
            Ochsenbein,A.F.
  TITLE     IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing
            of HSCs in response to hematopoietic stress and aging
  JOURNAL   iScience 28 (5), 112378 (2025)
   PUBMED   40384929
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 523)
  AUTHORS   Abe,S., Kagao,M., Asahi,T., Kato,R., Tani-Ichi,S., Shimba,A.,
            Ishibashi,R., Miyachi,H., Kitano,S., Miyazaki,M., Rodewald,H.R.,
            Toyoshima,F. and Ikuta,K.
  TITLE     The transcription factor RORalpha is required for the development
            of type 1 innate lymphoid cells in adult bone marrow
  JOURNAL   J Immunol 214 (4), 575-581 (2025)
   PUBMED   40079843
REFERENCE   3  (residues 1 to 523)
  AUTHORS   Monnier,C., Ganbold,M., Auclair,M., Roblot,N., Boutin,A.B.,
            Boutin,P.K., Feve,B. and Antoine,B.
  TITLE     RORalpha fine-tunes the circadian control of hepatic triglyceride
            synthesis and gluconeogenesis
  JOURNAL   Sci Rep 15 (1), 10464 (2025)
   PUBMED   40140523
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 523)
  AUTHORS   Ortiz,A., Ayhan,F., Khandelwal,N., Outland,E., Jankovic,M.,
            Harper,M. and Konopka,G.
  TITLE     Cell-type-specific roles of FOXP1 in the excitatory neuronal
            lineage during early neocortical murine development
  JOURNAL   Cell Rep 44 (3), 115384 (2025)
   PUBMED   40048431
REFERENCE   5  (residues 1 to 523)
  AUTHORS   Hua,X., Ficaro,M.K., Wallace,N.L. and Dai,J.
  TITLE     Epidermal RORalpha Maintains Barrier Integrity and Prevents
            Allergic Inflammation by Regulating Late Differentiation and Lipid
            Metabolism
  JOURNAL   Int J Mol Sci 25 (19), 10698 (2024)
   PUBMED   39409027
  REMARK    GeneRIF: Epidermal RORalpha Maintains Barrier Integrity and
            Prevents Allergic Inflammation by Regulating Late Differentiation
            and Lipid Metabolism.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 523)
  AUTHORS   Herrup,K. and Mullen,R.J.
  TITLE     Staggerer chimeras: intrinsic nature of Purkinje cell defects and
            implications for normal cerebellar development
  JOURNAL   Brain Res 178 (2-3), 443-457 (1979)
   PUBMED   509213
REFERENCE   7  (residues 1 to 523)
  AUTHORS   Herrup,K. and Mullen,R.J.
  TITLE     Regional variation and absence of large neurons in the cerebellum
            of the staggerer mouse
  JOURNAL   Brain Res 172 (1), 1-12 (1979)
   PUBMED   466453
REFERENCE   8  (residues 1 to 523)
  AUTHORS   Trenkner,E.
  TITLE     Postnatal cerebellar cells of staggerer mutant mice express
            immature components on their surface
  JOURNAL   Nature 277 (5697), 566-567 (1979)
   PUBMED   368650
REFERENCE   9  (residues 1 to 523)
  AUTHORS   Hatten,M.E. and Messer,A.
  TITLE     Postnatal cerebellar cells from staggerer mutant mice express
            embryonic cell surface characteristic
  JOURNAL   Nature 276 (5687), 504-506 (1978)
   PUBMED   723931
REFERENCE   10 (residues 1 to 523)
  AUTHORS   Landis,D.M. and Sidman,R.L.
  TITLE     Electron microscopic analysis of postnatal histogenesis in the
            cerebellar cortex of staggerer mutant mice
  JOURNAL   J Comp Neurol 179 (4), 831-863 (1978)
   PUBMED   641237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155931.2, AC160977.2 and CT009708.6.
            
            On Sep 3, 2004 this sequence version replaced XP_489717.1.
            
            Summary: The protein encoded by this gene is a member of the NR1
            subfamily of nuclear hormone receptors. It can bind as a monomer or
            as a homodimer to hormone response elements upstream of several
            genes to enhance the expression of those genes. The encoded protein
            has been shown to interact with NM23-2, a nucleoside diphosphate
            kinase involved in organogenesis and differentiation, as well as
            with NM23-1, the product of a tumor metastasis suppressor candidate
            gene. Also, it has been shown to aid in the transcriptional
            regulation of some genes involved in circadian rhythm. Three
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53228.1, SRR1660811.11443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 37.45 cM"
     Protein         1..523
                     /product="nuclear receptor ROR-alpha isoform 1"
                     /note="nuclear receptor ROR-alpha; nuclear receptor
                     RZR-alpha; retinoid-related orphan receptor-alpha; nuclear
                     receptor subfamily 1 group F member 1; RAR-related orphan
                     receptor A"
                     /calculated_mol_wt=58714
     Region          1..63
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51448.1)"
     Site            38
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P35398; propagated from
                     UniProtKB/Swiss-Prot (P51448.1)"
     Region          66..160
                     /region_name="NR_DBD_ROR"
                     /note="DNA-binding domain of Retinoid-related orphan
                     receptors (RORs) is composed of two C4-type zinc fingers;
                     cd06968"
                     /db_xref="CDD:143526"
     Site            order(73,76,90,93,109,115,125,128)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143526"
     Site            order(83..85,91..92,94,96,99,102,122..123,126,129,140,143)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143526"
     Region          154..183
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P51448.1)"
     Site            183
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAPK1.
                     /evidence=ECO:0000250|UniProtKB:P35398; propagated from
                     UniProtKB/Swiss-Prot (P51448.1)"
     Region          272..511
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(288..290,320,323..324,326..327,330,364,367..368,
                     370..371,379..381,391,394,403,484)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(339,349,352..353,356..357,505..506,509..510)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     Region          506..511
                     /region_name="AF-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P51448.1)"
     CDS             1..523
                     /gene="Rora"
                     /gene_synonym="9530021D13Rik; nmf267; Nr1f1; ROR1; ROR2;
                     ROR3; sg; staggerer; tmgc26"
                     /coded_by="NM_013646.3:87..1658"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23314.1"
                     /db_xref="GeneID:19883"
                     /db_xref="MGI:MGI:104661"
ORIGIN      
        1 mesapaapdp aasepgssgs eaaagsretp ltqdtgrkse apgagrrqsy asssrgisvt
       61 kkthtsqiei ipckicgdks sgihygvitc egckgffrrs qqsnatyscp rqknclidrt
      121 srnrcqhcrl qkclavgmsr davkfgrmsk kqrdslyaev qkhrmqqqqr dhqqqpgeae
      181 pltptynisa ngltelhddl stymdghtpe gskadsavss fyldiqpspd qsgldingik
      241 pepicdytpa sgffpycsft ngetsptvsm aelehlaqni skshletcqy lreelqqitw
      301 qtflqeeien yqnkqrevmw qlcaikitea iqyvvefakr idgfmelcqn dqivllkags
      361 levvfirmcr afdsqnntvy fdgkyaspdv fkslgcedfi sfvfefgksl csmhltedei
      421 alfsafvlms adrswlqekv kieklqqkiq lalqhvlqkn hredgiltkl ickvstlral
      481 cgrhteklma fkaiypdivr lhfpplykel ftsefepamq idg
//
LOCUS       NP_001416493             411 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear factor 1 B-type isoform 11 [Mus musculus].
ACCESSION   NP_001416493 XP_036019706
VERSION     NP_001416493.1
DBSOURCE    REFSEQ: accession NM_001429564.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 411)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 411)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 411)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   4  (residues 1 to 411)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 411)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 411)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 411)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (residues 1 to 411)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   9  (residues 1 to 411)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   10 (residues 1 to 411)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592283.5, BX324149.4 and AL773518.3.
            
            On Apr 23, 2024 this sequence version replaced XP_036019706.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.1417641.1,
                                           ERR3363658.4531665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.4 cM"
     Protein         1..411
                     /product="nuclear factor 1 B-type isoform 11"
                     /note="nuclear factor 1 B-type; nuclear factor 1/B;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /calculated_mol_wt=46304
     Region          2..38
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          60..164
                     /region_name="MH1"
                     /note="MH1 domain; pfam03165"
                     /db_xref="CDD:460833"
     Region          200..>406
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     CDS             1..411
                     /gene="Nfib"
                     /gene_synonym="6720429L07Rik; CTF; E030026I10Rik; NF-I/B;
                     NF1-B; NFI-B"
                     /coded_by="NM_001429564.1:184..1419"
                     /note="isoform 11 is encoded by transcript variant 11"
                     /db_xref="GeneID:18028"
                     /db_xref="MGI:MGI:103188"
ORIGIN      
        1 mdefhpfiea llphvraiay twfnlqarkr kyfkkhekrm skdeeravkd ellsekpeik
       61 qkwasrllak lrkdirqeyr edfvltvtgk khpccvlsnp dqkgkirrid clrqadkvwr
      121 ldlvmvilfk giplestdge rlmksphctn palcvqphhi tvsvkeldlf layyvqeqds
      181 gqsgspshsd paknppgyle dsfvksgvfn vselvrvsrt pitqgtgvnf pigeipsqpy
      241 yhdmnsgvnl qrslssppss krpktiside nmepsptgdf ypspnspaag srtwherdqd
      301 msspttmkkp ekplfsstsp qdssprlstf pqhhhpgipg vahsvistrt ppppsplpfp
      361 tqailppaps syfshptiry pphlnpqdtl knyvpsydps spqtsqswyl g
//
LOCUS       NP_001347908            2783 aa            linear   ROD 27-AUG-2025
DEFINITION  adenomatous polyposis coli protein isoform 2 [Mus musculus].
ACCESSION   NP_001347908 XP_017173293
VERSION     NP_001347908.1
DBSOURCE    REFSEQ: accession NM_001360979.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2783)
  AUTHORS   Kaltenecker,D., Fisker Schmidt,S., Weber,P., Loft,A., Morigny,P.,
            Machado,J., Geppert,J., Saul,K.B., Benedikt,P., Molocea,C.E.,
            Scott,R., Haase,K., Martignoni,M.E., Alfaro,A.J., Chow,K.K.,
            Simoes,E., Pinhata Otoch,J., Lima,J.D.C.C., Swanton,C.,
            Spielmann,N., Hrabe de Angelis,M., Elsner,M., Erturk,A., Dyar,K.A.,
            Rohm,M., Prokopchuk,O., Jamal-Hanjani,M., Seelaender,M., Backs,J.,
            Herzig,S. and Berriel Diaz,M.
  TITLE     Functional liver genomics identifies hepatokines promoting wasting
            in cancer cachexia
  JOURNAL   Cell 188 (17), 4549-4566 (2025)
   PUBMED   40695279
REFERENCE   2  (residues 1 to 2783)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2783)
  AUTHORS   Evans,A.E., Afroz,S., Magstadt,A., Kasi,A. and Dixon,D.A.
  TITLE     The XPO1 Inhibitor Eltanexor Modulates the Wnt/beta-Catenin
            Signaling Pathway to Reduce Colorectal Cancer Tumorigenesis
  JOURNAL   Cancer Res Commun 5 (7), 1140-1154 (2025)
   PUBMED   40601866
REFERENCE   4  (residues 1 to 2783)
  AUTHORS   Wang,X., Li,S., Liu,Y., Kuang,X., Chen,J., Yu,P., Zhao,L.,
            Zhang,Z., Huang,M., Liu,L., Zhang,M., Wang,Y., Ji,W., Li,J.,
            Zhang,L. and Chen,Y.G.
  TITLE     Positional BMP signaling orchestrates villus length in the small
            intestine
  JOURNAL   Nat Commun 16 (1), 5461 (2025)
   PUBMED   40595493
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2783)
  AUTHORS   Tomaz da Silva,M., Roy,A., Vuong,A.T., Joshi,A.S., Josphien,C.,
            Trivedi,M.V., Hindi,S.M., Narkar,V.A. and Kumar,A.
  TITLE     The TWEAK/Fn14 signaling mediates skeletal muscle wasting during
            cancer cachexia
  JOURNAL   iScience 28 (7), 112714 (2025)
   PUBMED   40585358
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2783)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (residues 1 to 2783)
  AUTHORS   Su,L.K., Kinzler,K.W., Vogelstein,B., Preisinger,A.C., Moser,A.R.,
            Luongo,C., Gould,K.A. and Dove,W.F.
  TITLE     Multiple intestinal neoplasia caused by a mutation in the murine
            homolog of the APC gene
  JOURNAL   Science 256 (5057), 668-670 (1992)
   PUBMED   1350108
  REMARK    Erratum:[Science 1992 May 22;256(5060):1114]
REFERENCE   8  (residues 1 to 2783)
  AUTHORS   Moser,A.R., Dove,W.F., Roth,K.A. and Gordon,J.I.
  TITLE     The Min (multiple intestinal neoplasia) mutation: its effect on gut
            epithelial cell differentiation and interaction with a modifier
            system
  JOURNAL   J Cell Biol 116 (6), 1517-1526 (1992)
   PUBMED   1541640
REFERENCE   9  (residues 1 to 2783)
  AUTHORS   Joslyn,G., Carlson,M., Thliveris,A., Albertsen,H., Gelbert,L.,
            Samowitz,W., Groden,J., Stevens,J., Spirio,L., Robertson,M. et al.
  TITLE     Identification of deletion mutations and three new genes at the
            familial polyposis locus
  JOURNAL   Cell 66 (3), 601-613 (1991)
   PUBMED   1678319
REFERENCE   10 (residues 1 to 2783)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114003.4, AL591373.8 and AC090534.10.
            
            On Feb 23, 2018 this sequence version replaced XP_017173293.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. These
            differences cause translation initiation at a downstream AUG and
            result in an isoform (2) with a shorter N-terminus, compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.131217.1,
                                           SRR7345562.2706322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.53 cM"
     Protein         1..2783
                     /product="adenomatous polyposis coli protein isoform 2"
                     /note="adenomatous polyposis coli protein; multiple
                     intestinal neoplasia; adenomatosis polyposis coli"
                     /calculated_mol_wt=304060
     Region          66..146
                     /region_name="Suppressor_APC"
                     /note="Adenomatous polyposis coli tumour suppressor
                     protein; pfam11414"
                     /db_xref="CDD:463275"
     Region          279..331
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          332..405
                     /region_name="APC_rep"
                     /note="Adenomatous polyposis coli (APC) repeat; pfam18797"
                     /db_xref="CDD:465870"
     Region          398..449
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          404..447
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(438,442,446,481,485,489,525,529,533)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          451..492
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          455..492
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          499..534
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          542..583
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          588..628
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          592..626
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          630..670
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          634..670
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          671..958
                     /region_name="Arm_APC_u3"
                     /note="Armadillo-associated region on APC; pfam16629"
                     /db_xref="CDD:435476"
     Region          975..1074
                     /region_name="APC_u5"
                     /note="Unstructured region on APC between 1st and 2nd
                     catenin-bdg motifs; pfam16630"
                     /db_xref="CDD:406923"
     Region          1196..>1213
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1222..1308
                     /region_name="APC_u9"
                     /note="Unstructured region on APC between 1st two
                     creatine-rich regions; pfam16633"
                     /db_xref="CDD:435478"
     Region          1576..1599
                     /region_name="APC_r"
                     /note="APC repeat; pfam05923"
                     /db_xref="CDD:461781"
     Region          1601..1654
                     /region_name="APC_u13"
                     /note="Unstructured region on APC between APC_crr and
                     SAMP; pfam16634"
                     /db_xref="CDD:406927"
     Region          1655..1676
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          1685..1778
                     /region_name="APC_u14"
                     /note="Unstructured region on APC between SAMP and
                     APC_crr; pfam16635"
                     /db_xref="CDD:435479"
     Region          1812..1886
                     /region_name="APC_u15"
                     /note="Unstructured region on APC between APC_crr regions
                     5 and 6; pfam16636"
                     /db_xref="CDD:435480"
     Region          1973..1992
                     /region_name="SAMP"
                     /note="SAMP Motif; pfam05924"
                     /db_xref="CDD:461782"
     Region          2164..2509
                     /region_name="APC_basic"
                     /note="APC basic domain; pfam05956"
                     /db_xref="CDD:428690"
     Region          2611..2783
                     /region_name="EB1_binding"
                     /note="EB-1 Binding Domain; pfam05937"
                     /db_xref="CDD:399141"
     CDS             1..2783
                     /gene="Apc"
                     /gene_synonym="CC1; mAPC; Min"
                     /coded_by="NM_001360979.1:249..8600"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:11789"
                     /db_xref="MGI:MGI:88039"
ORIGIN      
        1 mtsgqidlle rlkefnldsn fpgvklrskm slrsygsreg svssrsgecs pvpmgsfprr
       61 tfvngsrest gyleeleker sllladldke ekekdwyyaq lqnltkrids lpltenfslq
      121 tdmtrrqley earqiraame eqlgtcqdme kraqrriari qqiekdilrv rqllqsqaae
      181 aerssqsrhd aasheagrqh eghgvaesnt aasssgqspa trvdhetasv lsssgthsap
      241 rrltshlgtk vemvysllsm lgthdkddms rtllamsssq dscismrqsg clplliqllh
      301 gndkdsvllg nsrgskeara rasaalhnii hsqpddkrgr reirvlhlle qiraycetcw
      361 ewqeaheqgm dqdknpmpap vehqicpavc vlmklsfdee hrhamnelgg lqaiaellqv
      421 dcemygltnd hysvtlrrya gmaltnltfg dvankatlcs mkgcmralva qlksesedlq
      481 qviasvlrnl swradvnskk tlrevgsvka lmecalevkk estlksvlsa lwnlsahcte
      541 nkadicavdg alaflvgtlt yrsqtntlai iesgggilrn vssliatned hrqilrennc
      601 lqtllqhlks hsltivsnac gtlwnlsarn pkdqealwdm gavsmlknli hskhkmiamg
      661 saaalrnlma nrpakykdan imspgsslps lhvrkqkale aeldaqhlse tfdnidnlsp
      721 kashrskqrh kqnlygdyaf danrhddsrs dnfntgnmtv lspylnttvl psssssrgsl
      781 dssrsekdrs lerergigls ayhpttenag tsskrglqit ttaaqiakvm eevsaihtsq
      841 ddrssastte fhcvaddrsa arrssashth sntynftkse nsnrtcsmpy akveykrssn
      901 dslnsvtssd gygkrgqmkp svesysedde skfcsygqyp adlahkihsa nhmddndgel
      961 dtpinyslky sdeqlnsgrq spsqnerwar pkhviedeik qneqrqarsq ntsypvysen
     1021 tddkhlkfqp hfgqqecvsp yrsrgtsgse tnrmgsshai nqnvnqslcq eddyeddkpt
     1081 nyseryseee qheeeeerpt nysikyneek hhvdqpidys lkyatdisss qkpsfsfskn
     1141 ssaqstkpeh lspssentav ppsnakrqnq lrpssaqrng qtqkgttckv psinqetiqt
     1201 ycvedtpicf srcsslssls saddeigcdq ttqeadsant lqtaevkend vtrsaedpat
     1261 evpavsqnar akpsrlqasg lssestrhnk avefssgaks psksgaqtpk sppehyvqet
     1321 plvfsrctsv ssldsfesrs iassvqsepc sgmvsgiisp sdlpdspgqt mppsrsktpp
     1381 pppqtvqakr evpkskvpaa ekresgpkqt avnaavqrvq vlpdvdtllh fatestpdgf
     1441 scssslsals ldepfiqkdv elrimppvqe ndngnetese qpeesnenqd kevekpdsek
     1501 dllddsdddd ieileeciis amptkssrka kklaqtaskl pppvarkpsq lpvykllpaq
     1561 nrlqaqkhvs ftpgddvprv ycvegtpinf statslsdlt iesppnelat gdgvragiqs
     1621 gefekrdtip tegrstddaq rgkissivtp dlddnkaeeg dilaecinsa mpkgkshkpf
     1681 rvkkimdqvq qasstssgan knqvdtkkkk ptspvkpmpq nteyrtrvrk ntdskvnvnt
     1741 eetfsdnkds kkpslqtnak afneklpnne drvrgsfald sphhytpieg tpycfsrnds
     1801 lssldfdddd vdlsrekael rkgkeskdse akvtcrpepn ssqqaasksq asikhpanra
     1861 qskpvlqkqp tfpqsskdgp drgaatdekl qnfaientpv cfsrnsslss lsdidqennn
     1921 nkesepikea epansqgeps kpqasgyapk sfhvedtpvc fsrnsslssl sidseddllq
     1981 ecissampkk krpsrlkses ekqsprkvgg ilaedltldl kdlqrpdseh afspdsenfd
     2041 wkaiqegans ivsslhqaaa aaaclsrqas sdsdsilslk sgislgspfh ltpdqeekpf
     2101 tsnkgprilk pgekstleak kiesenkgik ggkkvyksli tgkirsnsei ssqmkqplpt
     2161 nmpsisrgrt mihipglrns ssstspvskk gpplktpask spsegpgatt sprgtkpagk
     2221 selspitrqt sqisgsnkgs srsgsrdstp srptqqplsr pmqspgrnsi spgrngispp
     2281 nklsqlprts spstastkss gsgkmsytsp grqlsqqnlt kqaslsknas siprsesask
     2341 glnqmsngng snkkvelsrm sstkssgses drserpalvr qstfikeaps ptlrrklees
     2401 asfeslspss rpdsptrsqa qtpvlspslp dmslsthpsv qaggwrklpp nlsptieynd
     2461 grptkrhdia rshsespsrl pinragtwkr ehskhssslp rvstwrrtgs sssilsasse
     2521 ssekaksede rhvssmpapr qmkenqvptk gtwrkikesd isptgmasqs assgaasgae
     2581 skpliyqmap pvsktedvwv riedcpinnp rsgrsptgnt ppvidsvsek gsssikdskd
     2641 thgkqsvgsg spvqtvglet rlnsfvqvea peqkgteakp gqsnpvsiae taetciaert
     2701 pfsssssskh sspsgtvaar vtpfnynpsp rkssadstsa rpsqiptpvs tntkkrdskt
     2761 dstessgaqs pkrhsgsylv tsv
//
LOCUS       NP_001390175              75 aa            linear   ROD 27-AUG-2025
DEFINITION  GTPase KRas isoform 4 [Mus musculus].
ACCESSION   NP_001390175
VERSION     NP_001390175.1
DBSOURCE    REFSEQ: accession NM_001403246.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 75)
  AUTHORS   Hetzel,S., Hodis,E., Torlai Triglia,E., Kovacsovics,A.,
            Steinmann,K., Gnirke,A., Cui,M., McQuaid,D., Weigert,R., Pohl,G.,
            Muzumdar,M.D., Leyvraz,S., Keilholz,U., Yaspo,M.L., Regev,A.,
            Kretzmer,H., Smith,Z.D. and Meissner,A.
  TITLE     Direct genetic transformation bypasses tumor-associated DNA
            methylation alterations
  JOURNAL   Genome Biol 26 (1), 212 (2025)
   PUBMED   40676699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 75)
  AUTHORS   Quijano,E., Martinez-Saucedo,D., Ianniello,Z., Pinto-Medici,N.,
            Rackear,M., Chen,H., Lola-Pereira,L., Liu,Y., Hegan,D., Shan,X.,
            Tseng,R., Yugawa,D., Chowdhury,S., Khang,M., Singh,J.P.,
            Abdullah,R., Azhir,P., Kashima,S., Woods,W.S., Gosstola,N.,
            Turner,B.C., Squinto,S., Ludwig,D.L., Bindra,R.S., Robert,M.E.,
            Braun,D.A., Perez Pinera,P., Saltzman,W.M., Escobar-Hoyos,L.F. and
            Glazer,P.M.
  TITLE     Systemic administration of an RNA binding and cell-penetrating
            antibody targets therapeutic RNA to multiple mouse models of cancer
  JOURNAL   Sci Transl Med 17 (807), eadk1868 (2025)
   PUBMED   40668891
REFERENCE   3  (residues 1 to 75)
  AUTHORS   Suzuki,Y., Sugimori,M., Kanemaru,Y., Onodera,S., Tsuchiya,H.,
            Ikeda,A., Ikeda,R., Goda,Y., Kaneko,H., Irie,K., Sue,S., Ijichi,H.
            and Maeda,S.
  TITLE     Development of a novel PIK3CA-mutated pancreatic tumor mouse model
            and evaluation of the therapeutic effects of a PI3K inhibitor
  JOURNAL   PLoS One 20 (7), e0326491 (2025)
   PUBMED   40638603
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 75)
  AUTHORS   Poirier,A., Tribouillard,L., Kordahi,M., Gelinas,Y., Roy,J.,
            Beaulieu,M.J., Orain,M., Blanchet,M.R., Joubert,P. and Laplante,M.
  TITLE     Generation and characterization of a Cre-inducible ZNF768
            overexpression mouse model
  JOURNAL   Sci Rep 15 (1), 19792 (2025)
   PUBMED   40473701
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 75)
  AUTHORS   Woo,S.M., Lee,H., Kang,J.H., Kang,M., Choi,W., Sim,S.H., Chun,J.W.,
            Han,N., Kim,K.H., Ham,W., Hong,W., Kim,C., Park,J.H., Han,D.,
            Yook,J.I., Lee,W.J. and Kim,S.Y.
  TITLE     Loss of SLC25A20 in Pancreatic Adenocarcinoma Reversed the
            Tumor-Promoting Effects of a High-Fat Diet
  JOURNAL   Theranostics 15 (13), 6516-6533 (2025)
   PUBMED   40521210
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 75)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (residues 1 to 75)
  AUTHORS   Lord,P.G., Hardaker,K.J., Loughlin,J.M., Marsden,A.M. and
            Orton,T.C.
  TITLE     Point mutation analysis of ras genes in spontaneous and chemically
            induced C57Bl/10J mouse liver tumours
  JOURNAL   Carcinogenesis 13 (8), 1383-1387 (1992)
   PUBMED   1499088
REFERENCE   8  (residues 1 to 75)
  AUTHORS   You,M., Wang,Y., Stoner,G., You,L., Maronpot,R., Reynolds,S.H. and
            Anderson,M.
  TITLE     Parental bias of Ki-ras oncogenes detected in lung tumors from
            mouse hybrids
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5804-5808 (1992)
   PUBMED   1352876
REFERENCE   9  (residues 1 to 75)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (residues 1 to 75)
  AUTHORS   Scolnick,E.M., Papageorge,A.G. and Shih,T.Y.
  TITLE     Guanine nucleotide-binding activity as an assay for src protein of
            rat-derived murine sarcoma viruses
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5355-5359 (1979)
   PUBMED   228288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157091.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1907448.1,
                                           SRR13948564.1655849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..75
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     Protein         1..75
                     /product="GTPase KRas isoform 4"
                     /EC_number="3.6.5.2"
                     /note="Kirsten rat sarcoma oncogene 2, expressed; p21
                     protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene
                     homolog; GTPase KRas"
                     /calculated_mol_wt=8415
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P01116; propagated from
                     UniProtKB/Swiss-Prot (P32883.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine, in GTPase KRas, N-terminally
                     processed. /evidence=ECO:0000250|UniProtKB:P01116;
                     propagated from UniProtKB/Swiss-Prot (P32883.1)"
     Region          3..>37
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            10..17
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133338"
     Site            35
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133338"
     CDS             1..75
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /coded_by="NM_001403246.1:203..430"
                     /note="isoform 4 is encoded by transcript variant 8"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
ORIGIN      
        1 mteyklvvvg aggvgksalt iqliqnhfvd eydptiegvd dafytlvrei rkhkekmskd
       61 gkkkkkksrt rctvm
//
LOCUS       NP_058654                484 aa            linear   ROD 27-AUG-2025
DEFINITION  keratin, type I cytoskeletal 14 isoform 1 [Mus musculus].
ACCESSION   NP_058654
VERSION     NP_058654.1
DBSOURCE    REFSEQ: accession NM_016958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Recka,N., Simons,A., Cornell,R.A. and Van Otterloo,E.
  TITLE     Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal
            Keratinocyte-Like Cell Population and Defective Epidermal
            Stratification
  JOURNAL   J Invest Dermatol (2025) In press
   PUBMED   40339790
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Wang,X., Cheng,M., Chen,S., Zhang,C., Ling,R., Qiu,S., Chen,K.,
            Zhou,B., Li,Q., Lei,W. and Chen,D.
  TITLE     Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck
            cancer is mediated by Sox9+ tumor cells interaction with Fpr1+
            neutrophils
  JOURNAL   Nat Commun 16 (1), 3975 (2025)
   PUBMED   40295483
  REMARK    Erratum:[Nat Commun. 2025 May 30;16(1):5042. doi:
            10.1038/s41467-025-60473-2. PMID: 40447624]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Gerner-Mauro,K.N., Vila Ellis,L., Wang,G., Nayak,R., Lwigale,P.Y.,
            Poche,R.A. and Chen,J.
  TITLE     Morphogenic, molecular and cellular adaptations for unidirectional
            airflow in the chicken lung
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40177910
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Rudat,C., Straube,P., Hegermann,J., Trowe,M.O., Thiesler,H.,
            Hildebrandt,H., Witt,L. and Kispert,A.
  TITLE     PPARG contributes to urothelial integrity in the murine ureter by
            activating the expression of Shh and superficial cell-specific
            genes
  JOURNAL   Development 152 (8) (2025)
   PUBMED   40167323
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Hu,A., Pickup,M.E., Lawal,M.A., Patel,H.J. and Ahmed,M.I.
  TITLE     The involvement of Elf5 in regulating keratinocyte proliferation
            and differentiation processes in skin
  JOURNAL   PLoS One 20 (1), e0316134 (2025)
   PUBMED   39752333
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Gimenez-Conti,I.B., Lynch,M., Roop,D., Bhowmik,S., Majeski,P. and
            Conti,C.J.
  TITLE     Expression of keratins in mouse vaginal epithelium
  JOURNAL   Differentiation 56 (3), 143-151 (1994)
   PUBMED   7518402
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Bonifas,J.M., Bare,J.W., Lynch,E.D., Lebo,R.V. and Epstein,E.H. Jr.
  TITLE     Regional assignment of the human keratin 5 (KRT5) gene to
            chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids
            and multicolor in situ hybridization
  JOURNAL   Genomics 13 (2), 452-454 (1992)
   PUBMED   1377166
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Correll,A.T., Webb,G.C., Ford,J.H., Rogers,G.E. and Powell,B.C.
  TITLE     Localization by in situ hybridization of a type I keratin
            intermediate filament gene (Krt-1.14) to band D of mouse chromosome
            11
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 245-246 (1992)
   PUBMED   1380418
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Stoler,A., Kopan,R., Duvic,M. and Fuchs,E.
  TITLE     Use of monospecific antisera and cRNA probes to localize the major
            changes in keratin expression during normal and abnormal epidermal
            differentiation
  JOURNAL   J Cell Biol 107 (2), 427-446 (1988)
   PUBMED   2458356
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Three cDNA sequences of mouse type I keratins. Cellular
            localization of the mRNAs in normal and hyperproliferative tissues
  JOURNAL   J Biol Chem 262 (2), 938-945 (1987)
   PUBMED   2433272
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17, AA760592.1,
            AA499338.1, AA562488.1, AI893364.1 and AA612291.1.
            
            Summary: This gene encodes a member of the keratin family, the most
            diverse group of intermediate filaments. This gene product, a type
            I keratin, is usually found as a heterotetramer with two keratin 5
            molecules, a type II keratin. Together they form the cytoskeleton
            of epithelial cells. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011074.1, SRR13948564.3773758.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.43 cM"
     Protein         1..484
                     /product="keratin, type I cytoskeletal 14 isoform 1"
                     /note="keratin, type I cytoskeletal 14; cytokeratin 14;
                     keratin complex 1, acidic, gene 14"
                     /calculated_mol_wt=52736
     Region          1..120
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          120..431
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          121..156
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          157..174
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          175..266
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          267..289
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          290..428
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Site            370
                     /site_type="other"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (Q61781.2)"
     Region          429..484
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          431..484
                     /region_name="Interaction with Type I keratins and keratin
                     filaments. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Region          435..457
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61781.2)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61781.2)"
     CDS             1..484
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /coded_by="NM_016958.2:56..1510"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25413.1"
                     /db_xref="GeneID:16664"
                     /db_xref="MGI:MGI:96688"
ORIGIN      
        1 matcsrqfts sssmkgscgi gggssrmssi laggscraps tyggmsvtss rfssggacgi
       61 gggyggsfss ssfggglgsg fggrfdgfgg gfggglgggf ggglggglgg gigdgllvgs
      121 ekvtmqnlnd rlatyldkvr aleeantele vkirdwyqrq rpteikdysp yfktiedlks
      181 kilaatvdna nvllqidnar laaddfrtkf eteqslrmsv eadinglrrv ldeltlarad
      241 lemqieslke elaylkknhe eemasmrgqv ggdvnvemda apgvdlsril nemrdqyekm
      301 aeknrkdaee wffskteeln revatnselv qsgkseisel rrtmqnleie lqsqlsmkas
      361 lennleetkg rycmqlaqiq emigsveeql aqlrcemeqq nqeykilldv ktrleqeiat
      421 yrrllegeda hlsssqfsss sqfssgsqss rdvtstnrqi rtkvmdvhdg kvvstheqvl
      481 rtkn
//
LOCUS       NP_542365               1002 aa            linear   ROD 27-AUG-2025
DEFINITION  BLOC-2 complex member HPS3 isoform 1 [Mus musculus].
ACCESSION   NP_542365
VERSION     NP_542365.3
DBSOURCE    REFSEQ: accession NM_080634.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1002)
  AUTHORS   Wang,J.Y., Michki,S.N., Sitaraman,S., Banaschewski,B.J., Jamal,R.,
            Gokey,J.J., Lin,S.M., Katzen,J.B., Basil,M.C., Cantu,E.,
            Kropski,J.A., Zepp,J.A., Frank,D.B. and Young,L.R.
  TITLE     Dysregulated alveolar epithelial cell progenitor function and
            identity in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 10 (3), e183483 (2024)
   PUBMED   39699958
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1002)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1002)
  AUTHORS   Kook,S., Qi,A., Wang,P., Meng,S., Gulleman,P., Young,L.R. and
            Guttentag,S.H.
  TITLE     Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak
            Syndromes
  JOURNAL   Am J Respir Cell Mol Biol 58 (5), 566-574 (2018)
   PUBMED   29190429
REFERENCE   4  (residues 1 to 1002)
  AUTHORS   Young,L.R., Gulleman,P.M., Short,C.W., Tanjore,H., Sherrill,T.,
            Qi,A., McBride,A.P., Zaynagetdinov,R., Benjamin,J.T., Lawson,W.E.,
            Novitskiy,S.V. and Blackwell,T.S.
  TITLE     Epithelial-macrophage interactions determine pulmonary fibrosis
            susceptibility in Hermansky-Pudlak syndrome
  JOURNAL   JCI Insight 1 (17), e88947 (2016)
   PUBMED   27777976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1002)
  AUTHORS   Li,K., Yang,L., Zhang,C., Niu,Y., Li,W. and Liu,J.J.
  TITLE     HPS6 interacts with dynactin p150Glued to mediate retrograde
            trafficking and maturation of lysosomes
  JOURNAL   J Cell Sci 127 (Pt 21), 4574-4588 (2014)
   PUBMED   25189619
REFERENCE   6  (residues 1 to 1002)
  AUTHORS   McGarry,M.P., Reddington,M., Novak,E.K. and Swank,R.T.
  TITLE     Survival and lung pathology of mouse models of Hermansky-Pudlak
            syndrome and Chediak-Higashi syndrome
  JOURNAL   Proc Soc Exp Biol Med 220 (3), 162-168 (1999)
   PUBMED   10193444
REFERENCE   7  (residues 1 to 1002)
  AUTHORS   Odorizzi,G., Cowles,C.R. and Emr,S.D.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   8  (residues 1 to 1002)
  AUTHORS   Cornwell,M.M.
  TITLE     Molecular biology of P-glycoprotein
  JOURNAL   Cancer Treat Res 57, 37-56 (1991)
   PUBMED   1686722
  REMARK    Review article
REFERENCE   9  (residues 1 to 1002)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   10 (residues 1 to 1002)
  AUTHORS   Novak,E.K., Sweet,H.O., Prochazka,M., Parentis,M., Soble,R.,
            Reddington,M., Cairo,A. and Swank,R.T.
  TITLE     Cocoa: a new mouse model for platelet storage pool deficiency
  JOURNAL   Br J Haematol 69 (3), 371-378 (1988)
   PUBMED   3408670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036663.1 and BC058235.1.
            
            On Apr 7, 2009 this sequence version replaced NP_542365.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058235.1, AK034377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 6.12 cM"
     Protein         1..1002
                     /product="BLOC-2 complex member HPS3 isoform 1"
                     /note="hermansky-Pudlak syndrome 3 protein homolog; cocoa
                     protein; Hermansky-Pudlak syndrome 3 homolog; BLOC-2
                     complex member HPS3"
                     /calculated_mol_wt=113051
     Region          3..212
                     /region_name="HPS3_N"
                     /note="Hermansky-Pudlak syndrome 3; pfam14761"
                     /db_xref="CDD:464300"
     Region          218..239
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VB4.2)"
     Region          255..640
                     /region_name="HPS3_Mid"
                     /note="Hermansky-Pudlak syndrome 3, middle region;
                     pfam14762"
                     /db_xref="CDD:464301"
     Region          649..1000
                     /region_name="HPS3_C"
                     /note="Hermansky-Pudlak syndrome 3, C-terminal; pfam14763"
                     /db_xref="CDD:464302"
     CDS             1..1002
                     /gene="Hps3"
                     /gene_synonym="coa"
                     /coded_by="NM_080634.4:46..3054"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17260.1"
                     /db_xref="GeneID:12807"
                     /db_xref="MGI:MGI:2153839"
ORIGIN      
        1 mvrlynlhpf gsqqvvpcqw epeqvccggs dalfvaagck veafavqgee lcrqrcafst
       61 lgrvlrmays eagdylvaie eknktiflra yvnwrskrsd nsrvcirmvg hnveasfces
      121 frdqmsiiem pmseaplcfs ccpvkgdllv gctnklvlft lkydiineef silnfersli
      181 ihidnitpve isfcvgyvav msdlevlllk lesdpihges vdhhpqetsn plkeaegvsn
      241 etsqlesedf viclkpmeli gekceqsgis vklestgled ekvkylrvrh llyrrfapdi
      301 ssyvlsdnik lhslqllpih qsgfhpdend lspkkempnl fcffslphvg ylymvvksve
      361 lmsvywypek sqqavltpqf lhvitsqslq cftvrcsaav aheedlymdt tlkacppvsm
      421 dvcalriqlf iglkaichfk nhiilltkae peaiperres pkklisrkda svrsgtphva
      481 eaawnlylvn ttapvqlyke mvdysnsykt vktesclhll seahllvraa lmdgsqlepa
      541 ekaelleafk escghlgdcy srltteqshl alpyykmsgl slaevlarvd wteesesqky
      601 erglvfyinh slyenldeel skelaakvaq ifhmaepkql phvlsspsmk nidpltalhy
      661 lrkldscgvs pvlvtltkaa valkmgdldm yrnemkshse mklvygfile prlliqqwkg
      721 qivptelaid lketqpgllv asvlglqknd kigivetdsf fkvlcgkded avpqllidfw
      781 eaqlvaclpn vvleelffkl isqyvwrlse rrcpdtvplr taedlinacs hyglvnpwvh
      841 vlttsdslad knytddllkl qslicspsld vasiipflep lsedtvagls thalchtrlq
      901 eyeqcidtll ercpeaviay anqelkedhw ilwwkkllpe lcqrvksgge rshlhlsllk
      961 etlsviavgl dlrdflnvlp edgaaafflp yllfcsrkks lt
//
LOCUS       NP_001396747             737 aa            linear   ROD 27-AUG-2025
DEFINITION  histone-lysine N-methyltransferase EZH2 isoform 4 [Mus musculus].
ACCESSION   NP_001396747 XP_006505586
VERSION     NP_001396747.1
DBSOURCE    REFSEQ: accession NM_001409818.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 737)
  AUTHORS   Jiao,F., Tang,T., Wang,B., He,S., Zhang,Y., Dong,L., Xu,B., Liu,Y.,
            Zhu,P. and Guo,R.
  TITLE     RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
  JOURNAL   Adv Sci (Weinh) 12 (19), e2416350 (2025)
   PUBMED   40125808
REFERENCE   2  (residues 1 to 737)
  AUTHORS   Hoffman,O.R., Koehler,J.L., Espina,J.E.C., Patterson,A.M.,
            Gohar,E.S., Coleman,E.M., Schoenike,B.A., Espinosa-Garcia,C.,
            Paredes,F., Varvel,N.H., Dingledine,R.J., Maguire,J.L. and
            Roopra,A.S.
  TITLE     Disease modification upon 2 weeks of tofacitinib treatment in a
            mouse model of chronic epilepsy
  JOURNAL   Sci Transl Med 17 (790), eadt0527 (2025)
   PUBMED   40106581
REFERENCE   3  (residues 1 to 737)
  AUTHORS   Xia,Y., Ye,Z., Li,B., Yan,X., Yuan,T., Li,L., Song,B., Yu,W.,
            Rao,T., Ning,J., Zhu,J., Li,X., Mei,S., Mao,Z., Zhou,X. and
            Cheng,F.
  TITLE     EZH2-mediated macrophage-to-myofibroblast transition contributes to
            calcium oxalate crystal-induced kidney fibrosis
  JOURNAL   Commun Biol 8 (1), 286 (2025)
   PUBMED   39987296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 737)
  AUTHORS   Liu,H., Ren,Q., Gong,M., Zuo,F., Li,Q., Huo,D., Yuan,Y., Zhang,Y.,
            Kong,Y., Liu,X., Lu,C. and Wu,X.
  TITLE     Enforced activation of the CREB/KDM2B axis prevents alcohol-induced
            embryonic developmental delay
  JOURNAL   Cell Rep 43 (12), 115075 (2024)
   PUBMED   39661511
REFERENCE   5  (residues 1 to 737)
  AUTHORS   Sadanandan,J., Thomas,S., Mathew,I.E., Huang,Z., Blackburn,S.L.,
            Tandon,N., Lokhande,H., McCrea,P.D., Bresnick,E.H., Dash,P.K.,
            McBride,D.W., Harmanci,A., Ahirwar,L.K., Jose,D., Dienel,A.C.,
            Zeineddine,H.A., Hong,S. and Kumar,T. P.
  TITLE     Key epigenetic and signaling factors in the formation and
            maintenance of the blood-brain barrier
  JOURNAL   Elife 12, 86978 (2024)
   PUBMED   39670988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 737)
  AUTHORS   Ogawa,M., Hiraoka,Y., Taniguchi,K. and Aiso,S.
  TITLE     Cloning and expression of a human/mouse Polycomb group gene,
            ENX-2/Enx-2
  JOURNAL   Biochim Biophys Acta 1395 (2), 151-158 (1998)
   PUBMED   9473645
REFERENCE   7  (residues 1 to 737)
  AUTHORS   Laible,G., Wolf,A., Dorn,R., Reuter,G., Nislow,C., Lebersorger,A.,
            Popkin,D., Pillus,L. and Jenuwein,T.
  TITLE     Mammalian homologues of the Polycomb-group gene Enhancer of zeste
            mediate gene silencing in Drosophila heterochromatin and at S.
            cerevisiae telomeres
  JOURNAL   EMBO J 16 (11), 3219-3232 (1997)
   PUBMED   9214638
REFERENCE   8  (residues 1 to 737)
  AUTHORS   Shirasawa,S., Yunker,A.M., Roth,K.A., Brown,G.A., Horning,S. and
            Korsmeyer,S.J.
  TITLE     Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
            and megacolon
  JOURNAL   Nat Med 3 (6), 646-650 (1997)
   PUBMED   9176491
REFERENCE   9  (residues 1 to 737)
  AUTHORS   Abel,K.J., Brody,L.C., Valdes,J.M., Erdos,M.R., McKinley,D.R.,
            Castilla,L.H., Merajver,S.D., Couch,F.J., Friedman,L.S.,
            Ostermeyer,E.A., Lynch,E.D., King,M.C., Welcsh,P.L.,
            Osborne-Lawrence,S., Spillman,M., Bowcock,A.M., Collins,F.S. and
            Weber,B.L.
  TITLE     Characterization of EZH1, a human homolog of Drosophila Enhancer of
            zeste near BRCA1
  JOURNAL   Genomics 37 (2), 161-171 (1996)
   PUBMED   8921387
REFERENCE   10 (residues 1 to 737)
  AUTHORS   Hobert,O., Sures,I., Ciossek,T., Fuchs,M. and Ullrich,A.
  TITLE     Isolation and developmental expression analysis of Enx-1, a novel
            mouse Polycomb group gene
  JOURNAL   Mech Dev 55 (2), 171-184 (1996)
   PUBMED   8861097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155652.25 and AC154015.3.
            
            On Jul 22, 2022 this sequence version replaced XP_006505586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1051958.1,
                                           SRR13422591.120085.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.92 cM"
     Protein         1..737
                     /product="histone-lysine N-methyltransferase EZH2 isoform
                     4"
                     /EC_number="2.1.1.356"
                     /note="histone-lysine N-methyltransferase EZH2; enhancer
                     of zeste homolog 2"
                     /calculated_mol_wt=84175
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="Interaction with EED"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          39..68
                     /region_name="EZH2_WD-Binding"
                     /note="WD repeat binding protein EZH2; pfam11616"
                     /db_xref="CDD:463308"
     Region          149..240
                     /region_name="PRC2_HTH_1"
                     /note="Polycomb repressive complex 2 tri-helical domain;
                     pfam18118"
                     /db_xref="CDD:436286"
     Region          171..208
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Region          320..513
                     /region_name="Interaction with CDYL.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            330
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          331..417
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61188.2)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CDK1 and CDK2.
                     /evidence=ECO:0000250|UniProtKB:Q15910; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            354
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Site            478
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61188.2)"
     Region          550..581
                     /region_name="preSET_CXC"
                     /note="CXC domain; pfam18264"
                     /db_xref="CDD:408079"
     Region          600..719
                     /region_name="SET_EZH2"
                     /note="SET domain found in enhancer of zeste homolog 2
                     (EZH2) and similar proteins; cd19218"
                     /db_xref="CDD:380995"
     Site            order(604,606..609,611,615,618,620,670..671,674,694,710)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:380995"
     Site            order(612..615,632,639,642..643,646,650,653..659,676..680,
                     688,715,717..718)
                     /site_type="active"
                     /db_xref="CDD:380995"
     Site            order(614..615,648..649,652,654,656,669,676..680,717)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380995"
     Site            order(614..615,648..649,652,654,656,669,676..679)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:380995"
     Site            order(632,639,642..643,646,650,655,657..659,688,715,
                     717..719)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380995"
     CDS             1..737
                     /gene="Ezh2"
                     /gene_synonym="Enx-1; Enx1h; KMT6; mKIAA4065"
                     /coded_by="NM_001409818.1:145..2358"
                     /note="isoform 4 is encoded by transcript variant 11"
                     /db_xref="GeneID:14056"
                     /db_xref="MGI:MGI:107940"
ORIGIN      
        1 mgqtgkksek gpvcwrkrvk seymrlrqlk rfrradevkt mfssnrqkil ertetlnqew
       61 kqrriqpvhi mtscsvtsdl dfpaqviplk tlnavasvpi myswsplqqn fmvedetvlh
      121 nipymgdevl dqdgtfieel iknydgkvhg drecgfinde ifvelvnalg qynddddddd
      181 gddpdereek qkdlednrdd ketcpprkfp adkifeaiss mfpdkgtaee lkekykelte
      241 qqlpgalppe ctpnidgpna ksvqreqslh sfhtlfcrrc fkydcflhpf hatpntykrk
      301 ntetaldnkp cgpqcyqhle gakefaaalt aeriktppkr pggrrrgrlp nnssrpstpt
      361 isvleskdtd sdreagtetg genndkeeee kkdetsssse ansrcqtpik mkpnieppen
      421 vewsgaeasm frvligtyyd nfcaiarlig tktcrqvyef rvkessiiap vptedvdtpp
      481 rkkkrkhrlw aahcrkiqlk kdgssnhvyn yqpcdhprqp cdsscpcvia qnfcekfcqc
      541 ssecqnrfpg crckaqcntk qcpcylavre cdpdlcltcg aadhwdsknv sckncsiqrg
      601 skkhlllaps dvagwgifik dpvqknefis eycgeiisqd eadrrgkvyd kymcsflfnl
      661 nndfvvdatr kgnkirfanh svnpncyakv mmvngdhrig ifakraiqtg eelffdyrys
      721 qadalkyvgi eremeip
//
LOCUS       NP_001106681             561 aa            linear   ROD 27-AUG-2025
DEFINITION  nuclear factor 1 B-type isoform 2 [Mus musculus].
ACCESSION   NP_001106681
VERSION     NP_001106681.1
DBSOURCE    REFSEQ: accession NM_001113210.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 561)
  AUTHORS   Gauberg,J., Jenkins,S., Moreno,K.B., Jayaraman,K., Abumeri,S.,
            Salazar,A., Meharena,H.S. and Glasgow,S.M.
  TITLE     Spinal motor neuron development and metabolism are
            transcriptionally regulated by nuclear factor IA
  JOURNAL   Sci Adv 11 (31), eadu3346 (2025)
   PUBMED   40749054
REFERENCE   2  (residues 1 to 561)
  AUTHORS   Anirudhan,J., Shen,X., Szemes,T., Dieu,M., Azouz,A., Conrard,L.,
            Passon,N., Doumont,G., Sitte,M., Achouri,Y., Kricha,S., Salinas,G.,
            Goriely,S., Renard,P. and Bellefroid,E.J.
  TITLE     Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex
            Development and Evidence for Dmrta2 Function in the Choroid Plexus
  JOURNAL   J Neurosci 45 (27), e1789242025 (2025)
   PUBMED   40456611
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 561)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   4  (residues 1 to 561)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 561)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 561)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 561)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (residues 1 to 561)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   9  (residues 1 to 561)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   10 (residues 1 to 561)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592283.5, BX324149.4 and AL773518.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4769425.1,
                                           SRR13948564.2814066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 38.4 cM"
     Protein         1..561
                     /product="nuclear factor 1 B-type isoform 2"
                     /note="nuclear factor 1 B-type; nuclear factor 1/B;
                     TGGCA-binding protein; CCAAT-box-binding transcription
                     factor"
                     /calculated_mol_wt=62560
     Region          10..47
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          69..173
                     /region_name="MH1"
                     /note="MH1 domain; pfam03165"
                     /db_xref="CDD:460833"
     Region          209..489
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     Region          252..446
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P97863.2)"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            286
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P97863.2)"
     Site            312
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00712; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            335
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Site            388
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P97863.2)"
     Region          397..405
                     /region_name="9aaTAD.
                     /evidence=ECO:0000250|UniProtKB:O00712"
                     /note="propagated from UniProtKB/Swiss-Prot (P97863.2)"
     CDS             1..561
                     /gene="Nfib"
                     /gene_synonym="6720429L07Rik; CTF; E030026I10Rik; NF-I/B;
                     NF1-B; NFI-B"
                     /coded_by="NM_001113210.3:620..2305"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:18028"
                     /db_xref="MGI:MGI:103188"
ORIGIN      
        1 mmyspicltq defhpfieal lphvraiayt wfnlqarkrk yfkkhekrms kdeeravkde
       61 llsekpeikq kwasrllakl rkdirqeyre dfvltvtgkk hpccvlsnpd qkgkirridc
      121 lrqadkvwrl dlvmvilfkg iplestdger lmksphctnp alcvqphhit vsvkeldlfl
      181 ayyvqeqdsg qsgspshsdp aknppgyled sfvksgvfnv selvrvsrtp itqgtgvnfp
      241 igeipsqpyy hdmnsgvnlq rslssppssk rpktisiden mepsptgdfy pspnspaags
      301 rtwherdqdm sspttmkkpe kplfsstspq dssprlstfp qhhhpgipgv ahsvistrtp
      361 pppsplpfpt qailppapss yfshptiryp phlnpqdtlk nyvpsydpss pqtsqpnssg
      421 qvvgkvpghf tpvlapsphp savrpvtltm tdtkpittst eaytasgtsq anryvglspr
      481 dpsflhqqql ricdwtmnqn grhlypstse dtlgitwqsp gtwaslvpfq vsnrtpilpa
      541 nvqnyglnii gepflqaets n
//
LOCUS       NP_034541                428 aa            linear   ROD 27-AUG-2025
DEFINITION  histone deacetylase 3 [Mus musculus].
ACCESSION   NP_034541
VERSION     NP_034541.2
DBSOURCE    REFSEQ: accession NM_010411.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 428)
  AUTHORS   Qian,S., Zhang,C., Li,W., Song,S., Lin,G., Cheng,Z., Zhou,W.,
            Yin,H., Wang,Y., Li,H., Shen,Y.H. and Sun,Z.
  TITLE     Enzyme-independent functions of HDAC3 in the adult heart
  JOURNAL   Acta Pharm Sin B 15 (7), 3561-3574 (2025)
   PUBMED   40698142
REFERENCE   2  (residues 1 to 428)
  AUTHORS   Li,J., Wang,C., Zhang,Y., Huang,Y., Shi,Z., Zhang,Y., Wang,Y.,
            Chen,S., Yuan,Y., Wang,H., Mao,L. and Gao,Y.
  TITLE     Orchestrating the frontline: HDAC3-miKO recruits macrophage
            reinforcements for accelerated myelin debris clearance after stroke
  JOURNAL   Theranostics 15 (2), 632-655 (2025)
   PUBMED   39744685
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 428)
  AUTHORS   Chen,H., Qin,A., Xu,F., Guo,S., Zhang,G., Zhang,A., Li,W., Tian,F.
            and Zheng,Q.
  TITLE     HDAC3 inhibitors induce drug resistance by promoting IL-17 A
            production by T cells
  JOURNAL   Sci Rep 14 (1), 31937 (2024)
   PUBMED   39738540
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 428)
  AUTHORS   Yang,M., Zhu,H., Peng,L., Yin,T., Sun,S., Du,Y., Li,J., Liu,J. and
            Wang,S.
  TITLE     Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to
            participate in stroke injury and post-stroke anxiety like behavior
  JOURNAL   Exp Neurol 380, 114906 (2024)
   PUBMED   39079624
  REMARK    GeneRIF: Neuronal HIPK2-HDAC3 axis regulates mitochondrial
            fragmentation to participate in stroke injury and post-stroke
            anxiety like behavior.
REFERENCE   5  (residues 1 to 428)
  AUTHORS   Zhang,J., Wang,G., Ma,J., Duan,Y., Sharma,S.A., Oladejo,S., Ma,X.,
            Arellano,G., Orchard,R.C., Reese,T.A. and Kuang,Z.
  TITLE     HDAC3 integrates TGF-beta and microbial cues to program tuft cell
            biogenesis and diurnal rhythms in mucosal immune surveillance
  JOURNAL   Sci Immunol 9 (99), eadk7387 (2024)
   PUBMED   39331726
REFERENCE   6  (residues 1 to 428)
  AUTHORS   Downes,M., Ordentlich,P., Kao,H.Y., Alvarez,J.G. and Evans,R.M.
  TITLE     Identification of a nuclear domain with deacetylase activity
  JOURNAL   Proc Natl Acad Sci U S A 97 (19), 10330-10335 (2000)
   PUBMED   10984530
REFERENCE   7  (residues 1 to 428)
  AUTHORS   Takami,Y. and Nakayama,T.
  TITLE     N-terminal region, C-terminal region, nuclear export signal, and
            deacetylation activity of histone deacetylase-3 are essential for
            the viability of the DT40 chicken B cell line
  JOURNAL   J Biol Chem 275 (21), 16191-16201 (2000)
   PUBMED   10748092
REFERENCE   8  (residues 1 to 428)
  AUTHORS   Mahlknecht,U., Hoelzer,D., Bucala,R. and Verdin,E.
  TITLE     Cloning and characterization of the murine histone deacetylase
            (HDAC3)
  JOURNAL   Biochem Biophys Res Commun 263 (2), 482-490 (1999)
   PUBMED   10491319
REFERENCE   9  (residues 1 to 428)
  AUTHORS   Dangond,F., Foerznler,D., Weremowicz,S., Morton,C.C., Beier,D.R.
            and Gullans,S.R.
  TITLE     Cloning and expression of a murine histone deacetylase 3 (mHdac3)
            cDNA and mapping to a region of conserved synteny between murine
            chromosome 18 and human chromosome 5
  JOURNAL   Mol Cell Biol Res Commun 2 (2), 91-96 (1999)
   PUBMED   10542131
REFERENCE   10 (residues 1 to 428)
  AUTHORS   Mahlknecht,U., Bucala,R. and Verdin,E.
  TITLE     Assignment of the histone deacetylase gene (Hdac3) to mouse
            chromosome 18B3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 192-193 (1999)
   PUBMED   10393429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166955.1, BQ932476.1, AF098295.1 and AK037478.1.
            
            On Mar 8, 2006 this sequence version replaced NP_034541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145158.1, AF074881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.81 cM"
     Protein         1..428
                     /product="histone deacetylase 3"
                     /EC_number="3.5.1.98"
                     /note="HD3; HDAC3 splicing HDAC3alpha; HDAC3 splicing
                     HDAC3beta; HDAC3 splicing HDAC3gamma; HDAC3 splicing
                     HDAC3delta; protein deacylase HDAC3; protein deacetylase
                     HDAC3"
                     /calculated_mol_wt=48690
     Region          3..383
                     /region_name="HDAC3"
                     /note="Histone deacetylase 3 (HDAC3); cd10005"
                     /db_xref="CDD:212529"
     Region          3..316
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (O88895.2)"
     Site            order(134..135,143..144,170,172,259,266,296,298)
                     /site_type="active"
                     /db_xref="CDD:212529"
     Region          388..428
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88895.2)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15379; propagated from
                     UniProtKB/Swiss-Prot (O88895.2)"
     CDS             1..428
                     /gene="Hdac3"
                     /coded_by="NM_010411.2:76..1362"
                     /db_xref="CCDS:CCDS37785.1"
                     /db_xref="GeneID:15183"
                     /db_xref="MGI:MGI:1343091"
ORIGIN      
        1 maktvayfyd pdvgnfhyga ghpmkphrla lthslvlhyg lykkmivfkp yqasqhdmcr
       61 fhsedyidfl qrvsptnmqg ftkslnafnv gddcpvfpgl fefcsrytga slqgatqlnn
      121 kicdiainwa gglhhakkfe asgfcyvndi vigilellky hprvlyidid ihhgdgvqea
      181 fyltdrvmtv sfhkygnyff pgtgdmyevg aesgryycln vplrdgiddq sykhlfqpvi
      241 sqvvdfyqpt civlqcgads lgcdrlgcfn lsirghgecv eyvksfnipl lvlggggytv
      301 rnvarcwtye tsllveeais eelpyseyfe yfapdftlhp dvstrienqn srqyldqirq
      361 tifenlkmln hapsvqihdv padlltydrt deadaeergp eenysrpeap nefydgdhdn
      421 dkesdvei
//
LOCUS       NP_001404112             501 aa            linear   ROD 27-AUG-2025
DEFINITION  transcription factor RelB isoform 3 [Mus musculus].
ACCESSION   NP_001404112 XP_030098103
VERSION     NP_001404112.1
DBSOURCE    REFSEQ: accession NM_001417183.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Geiselhoringer,A.L., Kolland,D., Patt,A.J., Hammann,L., Kohler,A.,
            Kreft,L., Wichmann,N., Hils,M., Ruedl,C., Riemann,M.,
            Biedermann,T., Anz,D., Diefenbach,A., Voehringer,D.,
            Schmidt-Weber,C.B., Straub,T., Pasztoi,M. and Ohnmacht,C.
  TITLE     Dominant immune tolerance in the intestinal tract imposed by
            RelB-dependent migratory dendritic cells regulates protective type
            2 immunity
  JOURNAL   Nat Commun 15 (1), 9143 (2024)
   PUBMED   39443450
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Deka,A., Kumar,N., Basu,S., Chawla,M., Bhattacharya,N., Ali,S.A.,
            Bhawna, Madan,U., Kumar,S., Das,B., Sengupta,D., Awasthi,A. and
            Basak,S.
  TITLE     Non-canonical NF-kappaB signaling limits the tolerogenic
            beta-catenin-Raldh2 axis in gut dendritic cells to exacerbate
            intestinal pathologies
  JOURNAL   EMBO J 43 (18), 3895-3915 (2024)
   PUBMED   39060515
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Lin,Y., Liu,M., Deng,P. and Zhang,J.
  TITLE     TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization
  JOURNAL   Cell Signal 120, 111210 (2024)
   PUBMED   38705503
  REMARK    GeneRIF: TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization.
            Erratum:[Cell Signal. 2024 Dec;124:111367. doi:
            10.1016/j.cellsig.2024.111367. PMID: 39214841]
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   5  (residues 1 to 501)
  AUTHORS   Zheng,C., Liu,L., Liu,C., Chu,F., Lang,Y., Liu,S., Mi,Y., Zhu,J.
            and Jin,T.
  TITLE     Alleviation of experimental autoimmune encephalomyelitis by
            transferring low RelB expression tolerogenic dendritic cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166934 (2024)
   PUBMED   37931715
  REMARK    GeneRIF: Alleviation of experimental autoimmune encephalomyelitis
            by transferring low RelB expression tolerogenic dendritic cells.
REFERENCE   6  (residues 1 to 501)
  AUTHORS   Burkly,L., Hession,C., Ogata,L., Reilly,C., Marconi,L.A., Olson,D.,
            Tizard,R., Cate,R. and Lo,D.
  TITLE     Expression of relB is required for the development of thymic
            medulla and dendritic cells
  JOURNAL   Nature 373 (6514), 531-536 (1995)
   PUBMED   7845467
REFERENCE   7  (residues 1 to 501)
  AUTHORS   Weih,F., Carrasco,D., Durham,S.K., Barton,D.S., Rizzo,C.A.,
            Ryseck,R.P., Lira,S.A. and Bravo,R.
  TITLE     Multiorgan inflammation and hematopoietic abnormalities in mice
            with a targeted disruption of RelB, a member of the NF-kappa B/Rel
            family
  JOURNAL   Cell 80 (2), 331-340 (1995)
   PUBMED   7834753
REFERENCE   8  (residues 1 to 501)
  AUTHORS   Egwuagu,C.E., Sztein,J., Chan,C.C., Mahdi,R., Nussenblatt,R.B. and
            Chepelinsky,A.B.
  TITLE     gamma Interferon expression disrupts lens and retinal
            differentiation in transgenic mice
  JOURNAL   Dev Biol 166 (2), 557-568 (1994)
   PUBMED   7813776
REFERENCE   9  (residues 1 to 501)
  AUTHORS   Lo,D., Quill,H., Burkly,L., Scott,B., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     A recessive defect in lymphocyte or granulocyte function caused by
            an integrated transgene
  JOURNAL   Am J Pathol 141 (5), 1237-1246 (1992)
   PUBMED   1443055
REFERENCE   10 (residues 1 to 501)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            On Mar 1, 2023 this sequence version replaced XP_030098103.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.15930497.1,
                                           SRR13861859.1996490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.93 cM"
     Protein         1..501
                     /product="transcription factor RelB isoform 3"
                     /note="transcription factor relB"
                     /calculated_mol_wt=54078
     Region          46..217
                     /region_name="RHD-n_RelB"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of the reticuloendotheliosis viral oncogene homolog
                     B (RelB) protein; cd07886"
                     /db_xref="CDD:143646"
     Site            order(60,62..63,65..66,68,70,72,152..154)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143646"
     Region          225..321
                     /region_name="RHD_dimer"
                     /note="Rel homology dimerization domain; pfam16179"
                     /db_xref="CDD:465045"
     Region          324..501
                     /region_name="RelB_transactiv"
                     /note="RelB transactivation domain; pfam16181"
                     /db_xref="CDD:406565"
     CDS             1..501
                     /gene="Relb"
                     /gene_synonym="shep"
                     /coded_by="NM_001417183.1:456..1961"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
ORIGIN      
        1 mprlvprgpa slssvtlgpa appppatpsw sctlgrlvsp gpcprpylvi teqpkqrgmr
       61 fryecegrsa gsilgesste asktlpaiel rdcgglreve vtaclvwkdw phrvhphslv
      121 gkdctdgvcr vrlrphvspr hsfnnlgiqc vrkkeieaai erkiqlgidp ynagslknhq
      181 evdmnvvric fqasyrdqqg hlhrmdpils epvydkkstn tselricrin kesgpctgge
      241 elyllcdkvq kedisvvfst aswegradfs qadvhrqiai vfktppyedl eisepvtvnv
      301 flqrltdgvc seplpftylp rdhdsygvdk krkrglpdvl gelsssdphg ieskrrkkkp
      361 vfldhflpgh ssglflppsa lqpadsdffp asislpglep pggpdllddg faydpsaptl
      421 ftmldllppa pplasavvgs ggagatvves sgpeplslds faapgpgdvg taslvgsnmf
      481 pnqyreaafg ggllspgpea t
//
LOCUS       NP_001005509             581 aa            linear   ROD 27-AUG-2025
DEFINITION  eukaryotic translation initiation factor 2A isoform 1 [Mus
            musculus].
ACCESSION   NP_001005509
VERSION     NP_001005509.1
DBSOURCE    REFSEQ: accession NM_001005509.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 581)
  AUTHORS   Li,C., Tan,Y.P., Gao,D., Su,R., Xu,K., Liu,S.C., Li,X.F., Lu,Y.H.,
            Yi,L.T., Wang,G., Ou,X.H., Meng,T.G. and Sun,Q.Y.
  TITLE     IRE1alpha RNase activity is critical for early embryo development
            by degrading maternal transcripts
  JOURNAL   Nucleic Acids Res 53 (11) (2025)
   PUBMED   40530690
REFERENCE   2  (residues 1 to 581)
  AUTHORS   Zhao,T., Jin,K., Wang,X., Su,X., Wang,Y., Gao,M., Luo,W., Yang,H.
            and Yang,Z.
  TITLE     GPAT4 sustains endoplasmic reticulum homeostasis in endocardial
            cells and safeguards heart development
  JOURNAL   Nat Commun 16 (1), 3345 (2025)
   PUBMED   40199910
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 581)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 581)
  AUTHORS   Huang,H., Liao,Y., Li,N., Qu,X., Li,C. and Hou,J.
  TITLE     The translation initiation factor eIF2alpha regulates lipid
            homeostasis and metabolic aging
  JOURNAL   Aging Cell 24 (1), e14348 (2025)
   PUBMED   39407444
REFERENCE   5  (residues 1 to 581)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 581)
  AUTHORS   Scheuner,D., Patel,R., Wang,F., Lee,K., Kumar,K., Wu,J.,
            Nilsson,A., Karin,M. and Kaufman,R.J.
  TITLE     Double-stranded RNA-dependent protein kinase phosphorylation of the
            alpha-subunit of eukaryotic translation initiation factor 2
            mediates apoptosis
  JOURNAL   J Biol Chem 281 (30), 21458-21468 (2006)
   PUBMED   16717090
  REMARK    GeneRIF: Double-stranded RNA-dependent protein kinase
            phosphorylation of the alpha-subunit of eukaryotic translation
            initiation factor 2 mediates apoptosis
REFERENCE   7  (residues 1 to 581)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (residues 1 to 581)
  AUTHORS   Datta,B., Majumdar,A., Datta,R. and Balusu,R.
  TITLE     Treatment of cells with the angiogenic inhibitor fumagillin results
            in increased stability of eukaryotic initiation factor 2-associated
            glycoprotein, p67, and reduced phosphorylation of extracellular
            signal-regulated kinases
  JOURNAL   Biochemistry 43 (46), 14821-14831 (2004)
   PUBMED   15544353
REFERENCE   9  (residues 1 to 581)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 581)
  AUTHORS   Ito,T., Jagus,R. and May,W.S.
  TITLE     Interleukin 3 stimulates protein synthesis by regulating
            double-stranded RNA-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7455-7459 (1994)
   PUBMED   7519779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121794.3 and AC119873.38.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078519.1, BC082557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.58 cM"
     Protein         1..581
                     /product="eukaryotic translation initiation factor 2A
                     isoform 1"
                     /note="eIF-2A"
                     /calculated_mol_wt=64272
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine, in Eukaryotic translation
                     initiation factor 2A, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          10..567
                     /region_name="COG5354"
                     /note="Uncharacterized protein, contains Trp-Asp (WD)
                     repeat [General function prediction only]"
                     /db_xref="CDD:227657"
     Region          23..63
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          125..163
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          216..411
                     /region_name="eIF2A"
                     /note="Eukaryotic translation initiation factor eIF2A;
                     pfam08662"
                     /db_xref="CDD:462552"
     Region          356..401
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Region          432..533
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            503
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            513
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BY44; propagated from
                     UniProtKB/Swiss-Prot (Q8BJW6.2)"
     CDS             1..581
                     /gene="Eif2a"
                     /gene_synonym="D030048D22; D3Ertd194e"
                     /coded_by="NM_001005509.3:17..1762"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17367.1"
                     /db_xref="GeneID:229317"
                     /db_xref="MGI:MGI:1098684"
ORIGIN      
        1 mapstplltv rgseglymvn gpphftestv lpresgrnck vytfskdgtl fawsngekvn
       61 iinvankgll hsfdlpkavc lefspnntvl atwqpyttsk dgtagtpnlq lydmktgacl
      121 ksfiqkkmqn wcpswsddei icarnvnnev hffennnfnt ianklhlqkv ndfnlspgtq
      181 pykvavyvpg skgapsfvrl yqypnfagpq aalanksffk adkvtmlwnk katavlvias
      241 tevdktgasy ygeqtlhyia tngesavvql pkngpiydvv wnssstefca vygfmpakat
      301 vfnlkcdpvf dfgtgprnaa fysphghilv lagfgnlrgq mevwdvknyk liskpvasds
      361 tyfawcpdge hiltatcapr lrvnngykiw hytgsllhky dvpsngelwq vswqpfldgi
      421 fpaktikyqa vpsevpseep kvatayrppa lrnkpvtnsk lheeeppqnm kphpgsdkpl
      481 sktalknqrk heakkaakqe arsdaaptpv pqsaprntvt qsasgdpevd kkiknlkkkl
      541 kaieqlkeqa aagkqleknq lekiqketal lqeledlelg v
//
LOCUS       NP_033348                681 aa            linear   ROD 27-AUG-2025
DEFINITION  T-box brain protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_033348
VERSION     NP_033348.2
DBSOURCE    REFSEQ: accession NM_009322.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 681)
  AUTHORS   Reichard,J., Wolff,P., Xie,S., Zuo,K., Fullio,C.L., Du,J.,
            Graff,S., Linde,J., Yildiz,C.B., Pitschelatow,G., Nabbefeld,G.,
            Dorp,L., Vollmer,J., Biemans,L., Kempf,S., Singh,M., Mohan,K.N.,
            Kuo,C.C., Vogel,T., Carloni,P., Musall,S. and Zimmer-Bensch,G.
  TITLE     DNMT1-mediated regulation of somatostatin-positive interneuron
            migration impacts cortical architecture and function
  JOURNAL   Nat Commun 16 (1), 6834 (2025)
   PUBMED   40707493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 681)
  AUTHORS   Hong,D., Shu,M., Liu,J., Liu,L., Cheng,H., Zhu,M., Du,Y., Xu,B.,
            Hu,D., Liu,Z., Zhao,Y., Dai,J., Lu,F. and Huang,J.
  TITLE     Divergent combinations of enhancers encode spatial gene expression
  JOURNAL   Nat Commun 16 (1), 5091 (2025)
   PUBMED   40456823
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 681)
  AUTHORS   Zhang,J., Che,P., Yang,Z., Zhang,P., Shui,Y., Lu,X., Xu,J., She,Y.,
            Zhang,Y., Yu,J. and Ji,S.J.
  TITLE     The m5C reader Ybx1 regulates embryonic cortical neurogenesis by
            promoting progenitor cell cycle progression
  JOURNAL   PLoS Biol 23 (5), e3003175 (2025)
   PUBMED   40435287
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 681)
  AUTHORS   Saha,S., Debacq,C., Audouard,C., Jungas,T., Dupre,P.,
            Mohamad-Ali,F., Chapat,C., Michaud,H.A., Le Cam,L., Lacroix,M.,
            Ohayon,D. and Davy,A.
  TITLE     Acute dietary methionine restriction triggers cell cycle arrest and
            reversible growth defects in the neocortex
  JOURNAL   iScience 28 (6), 112705 (2025)
   PUBMED   40524957
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 681)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 681)
  AUTHORS   Bulfone,A., Wang,F., Hevner,R., Anderson,S., Cutforth,T., Chen,S.,
            Meneses,J., Pedersen,R., Axel,R. and Rubenstein,J.L.
  TITLE     An olfactory sensory map develops in the absence of normal
            projection neurons or GABAergic interneurons
  JOURNAL   Neuron 21 (6), 1273-1282 (1998)
   PUBMED   9883721
REFERENCE   7  (residues 1 to 681)
  AUTHORS   Wattler,S., Russ,A., Evans,M. and Nehls,M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   8  (residues 1 to 681)
  AUTHORS   Acampora,D., Avantaggiato,V., Tuorto,F. and Simeone,A.
  TITLE     Genetic control of brain morphogenesis through Otx gene dosage
            requirement
  JOURNAL   Development 124 (18), 3639-3650 (1997)
   PUBMED   9342056
REFERENCE   9  (residues 1 to 681)
  AUTHORS   Qiu,M., Anderson,S., Chen,S., Meneses,J.J., Hevner,R., Kuwana,E.,
            Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
  JOURNAL   Dev Biol 178 (1), 174-178 (1996)
   PUBMED   8812118
REFERENCE   10 (residues 1 to 681)
  AUTHORS   Bulfone,A., Smiga,S.M., Shimamura,K., Peterson,A., Puelles,L. and
            Rubenstein,J.L.
  TITLE     T-brain-1: a homolog of Brachyury whose expression defines
            molecularly distinct domains within the cerebral cortex
  JOURNAL   Neuron 15 (1), 63-78 (1995)
   PUBMED   7619531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845291.5.
            
            On Aug 28, 2003 this sequence version replaced NP_033348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058399.1, U49251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.56 cM"
     Protein         1..681
                     /product="T-box brain protein 1 isoform 1"
                     /note="T-box brain protein 1; TBR-1; TES-56; T-brain-1;
                     T-box brain gene 1"
                     /calculated_mol_wt=73809
     Region          43..83
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2)"
     Region          108..127
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2)"
     Region          203..393
                     /region_name="T-box_TBR1"
                     /note="DNA-binding domain of T-box brain protein 1 and
                     related T-box proteins; cd20204"
                     /db_xref="CDD:410330"
     Site            order(231..232,265,267,310,313,329..330,370,372,378,381,
                     385..387,390..391)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410330"
     Site            order(249,251,284..286,292..293,323,342,356)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410330"
     Site            408
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2)"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2)"
     Region          418..679
                     /region_name="T-box_assoc"
                     /note="T-box transcription factor-associated; pfam16176"
                     /db_xref="CDD:465042"
     Region          447..483
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2)"
     Site            594
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2)"
     Region          597..655
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2)"
     Site            640
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2)"
     CDS             1..681
                     /gene="Tbr1"
                     /coded_by="NM_009322.4:114..2159"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16063.1"
                     /db_xref="GeneID:21375"
                     /db_xref="MGI:MGI:107404"
ORIGIN      
        1 mqlehclsps imlskkflnv sssyphsggs elvlhdhpii sttdnlerss plkkitrgmt
       61 nqsdtdnfpd skdspgdvqr sklspvldgv selrhsfdgs aadryllsqs sqpqsaatap
      121 samfpypsqh gpahpafsig spsrymahhp vitngaynsl lsnsspqgyp tagypypqqy
      181 ghsyqgapfy qfsstqpglv pgkaqvylcn rplwlkfhrh qtemiitkqg rrmfpflsfn
      241 isgldptahy nifvdvilad pnhwrfqggk wvpcgkadtn vqgnrvymhp dspntgahwm
      301 rqeisfgklk ltnnkgasnn ngqmvvlqsl hkyqprlhvv evnedgtedt sqpgrvqtft
      361 fpetqfiavt ayqntditql kidhnpfakg frdnydtiyt gcdmdrltps pndsprsqiv
      421 pgaryamags flqdqfvsny akarfhpgag agpgpgtdrs vphtngllsp qqaedpgaps
      481 pqrwfvtpan nrldfaasay dtatdfagna atllsyaaag vkalplqaag ctgrplgyya
      541 dpsgwgarsp pqycgaksgs vlpcwpnsaa aaarmaganp ylgeeaegla aersplapaa
      601 edakpkdlsd sswietpssi ksidssdsgi yeqakrrris padtpvsess splksevlaq
      661 rdcekncakd iggyygfysh s
//
LOCUS       NP_001415388             599 aa            linear   ROD 27-AUG-2025
DEFINITION  estrogen receptor isoform 1 [Mus musculus].
ACCESSION   NP_001415388
VERSION     NP_001415388.1
DBSOURCE    REFSEQ: accession NM_001428459.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 599)
  AUTHORS   Alcantara,I.C., Li,C., Gao,C., Rodriguez Gonzalez,S.,
            Mickelsen,L.E., Papas,B.N., Goldschmidt,A.I., Cohen,I.M.,
            Mazzone,C.M., de Araujo Salgado,I., Pinol,R.A., Xiao,C.,
            Karolczak,E.O., Li,J.L., Cui,G., Reitman,M.L. and Krashes,M.J.
  TITLE     A hypothalamic circuit that modulates feeding and parenting
            behaviours
  JOURNAL   Nature (2025) In press
   PUBMED   40739345
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 599)
  AUTHORS   Nawaito,S.A., Esmael,M., Souchkova,O., Cardinal,T., Bernas,G.,
            Bergeron,K.F., Gayda,F., Bergeron,F., Bouchard,M.F., Zhou,X.,
            Ongaro,L., Bernard,D.J., Short,J., Wray,S., Viger,R.S., Mounier,C.
            and Pilon,N.
  TITLE     Brain-Specific Gata4 Downregulation in Greywick Female Mice Models
            the Metabolic Subtype of Polycystic Ovary Syndrome
  JOURNAL   FASEB J 39 (12), e70717 (2025)
   PUBMED   40515561
REFERENCE   3  (residues 1 to 599)
  AUTHORS   Zha,X., Liu,X.Y., Wang,L., Li,S.S., Sun,Y.Z., Lin,J.K., Yan,J.J.,
            Gao,M.T., Zhang,Y.L., Yang,R.R., Xu,C. and Xu,X.H.
  TITLE     Estrogen signaling in the ventromedial hypothalamus is required for
            the development of aggression circuitry in male mice
  JOURNAL   Curr Biol 35 (11), 2684-2696 (2025)
   PUBMED   40403719
REFERENCE   4  (residues 1 to 599)
  AUTHORS   Terakawa,J., Nakamura,S., Ohtomo,M., Uehara,S., Kawata,Y.,
            Takarabe,S., Sugita,H., Namiki,T., Kageyama,A., Noguchi,M.,
            Murakami,H., Kashiwazaki,N. and Ito,J.
  TITLE     LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo
            Implantation in Mice
  JOURNAL   Biomolecules 15 (5), 698 (2025)
   PUBMED   40427591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 599)
  AUTHORS   Stomper,J., Niroula,A., Belizaire,R., McConkey,M., Bandaru,T.S. and
            Ebert,B.L.
  TITLE     Sex differences in DNMT3A-mutant clonal hematopoiesis and the
            effects of estrogen
  JOURNAL   Cell Rep 44 (4), 115494 (2025)
   PUBMED   40178977
REFERENCE   6  (residues 1 to 599)
  AUTHORS   Wu,T.C., Wang,L. and Wan,Y.J.
  TITLE     Expression of estrogen receptor gene in mouse oocyte and during
            embryogenesis
  JOURNAL   Mol Reprod Dev 33 (4), 407-412 (1992)
   PUBMED   1472372
REFERENCE   7  (residues 1 to 599)
  AUTHORS   Greco,T.L., Furlow,J.D., Duello,T.M. and Gorski,J.
  TITLE     Immunodetection of estrogen receptors in fetal and neonatal female
            mouse reproductive tracts
  JOURNAL   Endocrinology 129 (3), 1326-1332 (1991)
   PUBMED   1874174
REFERENCE   8  (residues 1 to 599)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   9  (residues 1 to 599)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (residues 1 to 599)
  AUTHORS   White,R., Lees,J.A., Needham,M., Ham,J. and Parker,M.
  TITLE     Structural organization and expression of the mouse estrogen
            receptor
  JOURNAL   Mol Endocrinol 1 (10), 735-744 (1987)
   PUBMED   2484714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158617.9, AC153573.3 and
            AC156393.12.
            
            Summary: This gene encodes an estrogen receptor, a member of the
            nuclear hormone family of intracellular receptors. The encoded
            protein, activated by the sex hormone estrogen, is a transcription
            factor composed of several domains important for hormone binding,
            DNA binding, and activation of transcription. Estrogen and its
            receptors are essential for sexual development and reproductive
            function, but also play a role in other tissues such as bone.
            Similar genes in human have been implicated in pathological
            processes including breast cancer, endometrial cancer, and
            osteoporosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.12965851.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.03 cM"
     Protein         1..599
                     /product="estrogen receptor isoform 1"
                     /note="estradiol receptor; nuclear receptor subfamily 3
                     group A member 1; C-terminally-truncated estrogen receptor
                     alpha product-5; C-terminally-truncated estrogen receptor
                     alpha product-6; C-terminally-truncated estrogen receptor
                     alpha product-7; C-terminally-truncated estrogen receptor
                     alpha product-4"
                     /calculated_mol_wt=66824
     Region          1..188
                     /region_name="Modulating (transactivation AF-1), mediates
                     interaction with MACROD1. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            10
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..178
                     /region_name="Interaction with DDX5, self-association.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          35..47
                     /region_name="Required for interaction with NCOA1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          42..185
                     /region_name="Oest_recep"
                     /note="Oestrogen receptor; pfam02159"
                     /db_xref="CDD:460469"
     Site            50
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            110
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          147..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          184..265
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Region          189..314
                     /region_name="Mediates interaction with DNTTIP2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(189,192,206,209,225,231,241,244)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(198..201,207..208,210..212,214..215,238..239,242,
                     245)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(224..227,231..232,237,240)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          255..314
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            264
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, by PRMT1.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          266..599
                     /region_name="Interaction with AKAP13.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          268..599
                     /region_name="Self-association. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Region          314..551
                     /region_name="NR_LBD_ER"
                     /note="Ligand binding domain of Estrogen receptor, which
                     are activated by the hormone 17beta-estradiol (estrogen);
                     cd06949"
                     /db_xref="CDD:132747"
     Region          315..599
                     /region_name="Transactivation AF-2. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            order(350,355,357,391,398,525,528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132747"
     Site            order(362,366,379..380,384,542,546..547)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            order(455,459,461..462,483,487..488,491,505..506,508..510,
                     512..513,516..517,519..520,523)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132747"
     Site            541
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250|UniProtKB:P03372; propagated from
                     UniProtKB/Swiss-Prot (P19785.1)"
     Region          556..599
                     /region_name="ESR1_C"
                     /note="Oestrogen-type nuclear receptor final C-terminal;
                     pfam12743"
                     /db_xref="CDD:432757"
     Region          557..581
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19785.1)"
     Site            575
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) threonine.
                     /evidence=ECO:0000269|PubMed:11226831,
                     ECO:0000269|PubMed:8999954. /id=CAR_000137; propagated
                     from UniProtKB/Swiss-Prot (P19785.1)"
     CDS             1..599
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /coded_by="NM_001428459.1:350..2149"
                     /note="isoform 1 is encoded by transcript variant 6"
                     /db_xref="GeneID:13982"
                     /db_xref="MGI:MGI:1352467"
ORIGIN      
        1 mtmtlhtkas gmallhqiqg neleplnrpq lkmpmeralg evyvdnskpt vfnypegaay
       61 efnaaaaaaa aasapvygqs giaygpgsea aafsanslga fpqlnsvsps plmllhpppq
      121 lspflhphgq qvpyylenep sayavrdtgp pafyrsnsdn rrqngrerls ssnekgnmim
      181 esaketryca vcndyasgyh ygvwscegck affkrsiqgh ndymcpatnq ctidknrrks
      241 cqacrlrkcy evgmmkggir kdrrggrmlk hkrqrddleg rnemgasgdm raanlwpspl
      301 vikhtkknsp alsltadqmv salldaeppm iyseydpsrp fseasmmgll tnladrelvh
      361 minwakrvpg fgdlnlhdqv hllecawlei lmiglvwrsm ehpgkllfap nllldrnqgk
      421 cvegmveifd mllatssrfr mmnlqgeefv clksiillns gvytflsstl ksleekdhih
      481 rvldkitdtl ihlmakaglt lqqqhrrlaq lllilshirh msnkgmehly nmkcknvvpl
      541 ydlllemlda hrlhapasrm gvppeepsqt qlattsstsa hslqtyyipp eaegfpnti
//
LOCUS       NP_001289081             462 aa            linear   ROD 27-AUG-2025
DEFINITION  transcriptional regulator ERG isoform 2 [Mus musculus].
ACCESSION   NP_001289081 XP_006522964 XP_006523232
VERSION     NP_001289081.1
DBSOURCE    REFSEQ: accession NM_001302152.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Suresh,A., Kruse,K., Arf,H., Dieguez-Hurtado,R. and Adams,R.H.
  TITLE     ELMO2 is an essential regulator of carotid artery development
  JOURNAL   Nat Commun 16 (1), 5108 (2025)
   PUBMED   40456777
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Nguyen,L.D., Nguyen,L.H., Dao,D.X., Hattori,T., Takarada-Iemata,M.,
            Ishii,H., Tamatani,T., Kawasaki,H., Shinmyo,Y., Onoue,K.,
            Yonemura,S., Zhang,J., Miyake,M., Oyadomari,S., Mori,K. and Hori,O.
  TITLE     Impact of ATF6 deletion on the embryonic brain development
  JOURNAL   iScience 28 (6), 112569 (2025)
   PUBMED   40487428
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   4  (residues 1 to 462)
  AUTHORS   Yamashita,T., Kaplan,U., Chakraborty,A., Marden,G., Gritli,S.,
            Roh,D., Bujor,A., Trojanowski,M., Ligresti,G., Browning,J.L. and
            Trojanowska,M.
  TITLE     ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis
  JOURNAL   Arthritis Rheumatol 76 (11), 1645-1657 (2024)
   PUBMED   38965683
  REMARK    GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
REFERENCE   5  (residues 1 to 462)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
REFERENCE   6  (residues 1 to 462)
  AUTHORS   Fan,C.M., Kuwana,E., Bulfone,A., Fletcher,C.F., Copeland,N.G.,
            Jenkins,N.A., Crews,S., Martinez,S., Puelles,L., Rubenstein,J.L.
            and Tessier-Lavigne,M.
  TITLE     Expression patterns of two murine homologs of Drosophila
            single-minded suggest possible roles in embryonic patterning and in
            the pathogenesis of Down syndrome
  JOURNAL   Mol Cell Neurosci 7 (1), 1-16 (1996)
   PUBMED   8812055
  REMARK    Erratum:[Mol Cell Neurosci 1996 Jun;7(6):519]
REFERENCE   7  (residues 1 to 462)
  AUTHORS   Mjaatvedt,A.E., Cabin,D.E., Cole,S.E., Long,L.J., Breitwieser,G.E.
            and Reeves,R.H.
  TITLE     Assessment of a mutation in the H5 domain of Girk2 as a candidate
            for the weaver mutation
  JOURNAL   Genome Res 5 (5), 453-463 (1995)
   PUBMED   8808466
REFERENCE   8  (residues 1 to 462)
  AUTHORS   Rivera,R.R., Stuiver,M.H., Steenbergen,R. and Murre,C.
  TITLE     Ets proteins: new factors that regulate immunoglobulin heavy-chain
            gene expression
  JOURNAL   Mol Cell Biol 13 (11), 7163-7169 (1993)
   PUBMED   8413305
REFERENCE   9  (residues 1 to 462)
  AUTHORS   Mjaatvedt,A.E., Citron,M.P. and Reeves,R.H.
  TITLE     High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and
            Erg on distal mouse chromosome 16
  JOURNAL   Genomics 17 (2), 382-386 (1993)
   PUBMED   8406490
REFERENCE   10 (residues 1 to 462)
  AUTHORS   Reddy,E.S., Rao,V.N. and Papas,T.S.
  TITLE     The erg gene: a human gene related to the ets oncogene
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6131-6135 (1987)
   PUBMED   3476934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050922.1, AK078113.1, AC154691.3 and BP753340.1.
            
            On or before Oct 4, 2014 this sequence version replaced
            XP_006522964.1, XP_006523232.1.
            
            Transcript Variant: This variant (2) has a longer 5' UTR and lacks
            an alternate in-frame exon in the 3' coding region, compared to
            variant 1. The encoded isoform (2) is shorter compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.04 cM"
     Protein         1..462
                     /product="transcriptional regulator ERG isoform 2"
                     /note="transcriptional regulator ERG; avian
                     erythroblastosis virus E-26 (v-ets) oncogene related"
                     /calculated_mol_wt=51907
     Region          122..205
                     /region_name="SAM_superfamily"
                     /note="SAM (Sterile alpha motif); cl15755"
                     /db_xref="CDD:472832"
     Region          293..376
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..462
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /coded_by="NM_001302152.1:248..1636"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS79495.1"
                     /db_xref="GeneID:13876"
                     /db_xref="MGI:MGI:95415"
ORIGIN      
        1 miqtvpdpaa hikealsvvs edqslfecay gtphlaktem tassssdygq tskmsprvpq
       61 qdwlsqapar vtikmecnps qvngsrnspd ecsvnkggkm vgspdtvgms ygsymeekhv
      121 pppnmttner rvivpadptl wstdhvrqwl ewavkeygll dvdvllfqni dgkelckmtk
      181 ddfqrltpsy nadillshlh ylretplphl tsddvdkalq nsprlmharn tdlpyepprr
      241 sawtghshlt pqskaaqpsp savpktedqr pqldpyqilg ptssrlanpg sgqiqlwqfl
      301 lellsdssns ncitwegtng efkmtdpdev arrwgerksk pnmnydklsr alryyydkni
      361 mtkvhgkrya ykfdfhgiaq alqphppess lykypsdlpy mgsyhahpqk mnfvsphppa
      421 lpvtsssffa spnpywnspt ggiypntrlp ashmpshlgt yy
//
LOCUS       NP_001400282             695 aa            linear   ROD 27-AUG-2025
DEFINITION  short transient receptor potential channel 1 isoform 5 [Mus
            musculus].
ACCESSION   NP_001400282 XP_006511118
VERSION     NP_001400282.1
DBSOURCE    REFSEQ: accession NM_001413353.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 695)
  AUTHORS   Issa,F., Yerna,X., Parpaite,T., Jabbour,C., Schakman,O.,
            Tajeddine,N., Gualdani,R. and Gailly,P.
  TITLE     Conditional deletion of TRPC1 channel modulates synaptic
            plasticity, long term depression, and memory extinction in Fragile
            X syndrome mice
  JOURNAL   iScience 28 (8), 113085 (2025)
   PUBMED   40777047
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 695)
  AUTHORS   Ray,S., McCall,J.L., Tian,J.B., Jeon,J., Douglas,A., Tyler,K.,
            Liu,S., Berry,K., Nicewarner,B., Hall,C., Groschner,K., Bacsa,B.,
            Geldenhuys,W., Zhu,M.X., Blair,H.C., Barnett,J.B. and Soboloff,J.
  TITLE     Targeting TRPC channels for control of arthritis-induced bone
            erosion
  JOURNAL   Sci Adv 11 (3), eabm9843 (2025)
   PUBMED   39813349
REFERENCE   3  (residues 1 to 695)
  AUTHORS   Broker-Lai,J., Rego Terol,J., Richter,C., Mathar,I., Wirth,A.,
            Kopf,S., Moreno-Perez,A., Buttner,M., Tan,L.L., Makke,M.,
            Poschet,G., Hermann,J., Tsvilovskyy,V., Haberkorn,U.,
            Wartenberg,P., Susperreguy,S., Berlin,M., Ottenheijm,R.,
            Philippaert,K., Wu,M., Wiedemann,T., Herzig,S., Belkacemi,A.,
            Levinson,R.T., Agarwal,N., Camacho Londono,J.E., Klebl,B.,
            Dinkel,K., Zufall,F., Nussbaumer,P., Boehm,U., Hell,R., Nawroth,P.,
            Birnbaumer,L., Leinders-Zufall,T., Kuner,R., Zorn,M., Bruns,D.,
            Schwarz,Y. and Freichel,M.
  TITLE     TRPC5 controls the adrenaline-mediated counter regulation of
            hypoglycemia
  JOURNAL   EMBO J 43 (23), 5813-5836 (2024)
   PUBMED   39375537
REFERENCE   4  (residues 1 to 695)
  AUTHORS   Atkins,R.M., Pantalia,M., Skaggs,C., Lau,A.K., Mahmood,M.B.,
            Anwar,M.M., Barron,L., Eby,B., Khan,U., Tsiokas,L. and Lau,K.
  TITLE     Normotensive metabolic syndrome in Transient Receptor Potential
            Canonical Channel type 1 Trpc1-/- mice
  JOURNAL   Biol Open 13 (7) (2024)
   PUBMED   38885005
  REMARK    GeneRIF: Normotensive metabolic syndrome in Transient Receptor
            Potential Canonical Channel type 1 Trpc1-/- mice.
REFERENCE   5  (residues 1 to 695)
  AUTHORS   Lin,Y., Gao,R., Jing,D., Liu,Y., Da,H., Birnbaumer,L., Yang,Y.,
            Gao,X., Gao,Z. and Cao,Q.
  TITLE     TRPC absence induces pro-inflammatory macrophage polarization to
            promote obesity and exacerbate colorectal cancer
  JOURNAL   Front Pharmacol 15, 1392328 (2024)
   PUBMED   38835669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 695)
  AUTHORS   Schrick,J.J. and Lingrel,J.B.
  TITLE     cDNA cloning, mapping and expression of the mouse propionyl CoA
            carboxylase beta (pccb), the gene for human type II propionic
            acidaemia
  JOURNAL   Gene 264 (1), 147-152 (2001)
   PUBMED   11245989
REFERENCE   7  (residues 1 to 695)
  AUTHORS   Zhu,X. and Birnbaumer,L.
  TITLE     Calcium Channels Formed by Mammalian Trp Homologues
  JOURNAL   News Physiol Sci 13, 211-217 (1998)
   PUBMED   11390792
REFERENCE   8  (residues 1 to 695)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   9  (residues 1 to 695)
  AUTHORS   Sakura,H. and Ashcroft,F.M.
  TITLE     Identification of four trp1 gene variants murine pancreatic
            beta-cells
  JOURNAL   Diabetologia 40 (5), 528-532 (1997)
   PUBMED   9165220
REFERENCE   10 (residues 1 to 695)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091531.9 and AC157947.2.
            
            On Oct 31, 2022 this sequence version replaced XP_006511118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95168.1, SRR17784644.952528.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.2 cM"
     Protein         1..695
                     /product="short transient receptor potential channel 1
                     isoform 5"
                     /note="short transient receptor potential channel 1;
                     trp-related protein 1; transient receptor protein 1"
                     /calculated_mol_wt=80588
     Region          14..676
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     CDS             1..695
                     /gene="Trpc1"
                     /gene_synonym="Mtrp1; Trp1; Trrp1"
                     /coded_by="NM_001413353.1:649..2736"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:22063"
                     /db_xref="MGI:MGI:109528"
ORIGIN      
        1 mrsfscwrat rsadallvai dsevvgavdi llnhrpkrss rptivklmer iqnpeysttm
       61 dvapvilaah rnnyeiltml lkqdvslpkp havgcectlc saknkkdslr hsrfrldiyr
      121 claspaliml teedpilraf elsadlkels lvevefrndy eelarqckmf akdllaqarn
      181 srelevilnh tssdepldkr glleermnls rlklaikynq kefvsqsncq qflntvwfgq
      241 msgyrrkptc kkimtvltvg ifwpvlslcy liapksqfgr iihtpfmkfi ihgasyftfl
      301 lllnlyslvy nedkkntmgp aleridylli lwiigmiwsd ikrlwyegle dfleesrnql
      361 sfvmnslyla tfalkvvahn kfhdfadrkd wdafhptlva eglfafanvl sylrlffmyt
      421 tssilgplqi smgqmlqdfg kflgmfllvl fsftigltql ydkgytskeq kdcvgifceq
      481 qsndtfhsfi gtcfalfwyi fslahvaifv trfsygeelq sfvgavivgt ynvvvvivlt
      541 kllvamlhks fqlianhedk ewkfaraklw lsyfddkctl pppfniipsp kticymissl
      601 skwicshtsk gkvkrqnslk ewrnlkqkrd enyqkvmccl vhryltsmrq kmqstdqatv
      661 enlnelrqdl skfrneirdl lgfrtskyam fyprn
//
LOCUS       NP_620392                622 aa            linear   ROD 27-AUG-2025
DEFINITION  dopamine beta-hydroxylase [Mus musculus].
ACCESSION   NP_620392
VERSION     NP_620392.2
DBSOURCE    REFSEQ: accession NM_138942.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 622)
  AUTHORS   Liu,Y.A., Nong,Y., Feng,J., Li,G., Sajda,P., Li,Y. and Wang,Q.
  TITLE     Phase synchrony between prefrontal noradrenergic and cholinergic
            signals indexes inhibitory control
  JOURNAL   Nat Commun 16 (1), 7260 (2025)
   PUBMED   40770025
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 622)
  AUTHORS   Cheng,M., Wang,M., Wang,L., Yin,F., Shen,J., Xing,X., Shi,Y.,
            Liu,Z., Wu,P., Gao,W., Fan,Y., Cao,P. and Zhan,C.
  TITLE     Brainstem catecholaminergic neurons induce torpor during fasting by
            orchestrating cardiovascular and thermoregulation changes
  JOURNAL   Nat Commun 16 (1), 5954 (2025)
   PUBMED   40593766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 622)
  AUTHORS   Vas,S., Morris,P.G., Gul,Z., Ruiz-Cruz,M., Han,S.Y. and
            Herbison,A.E.
  TITLE     Brainstem noradrenergic modulation of the kisspeptin neuron GnRH
            pulse generator in mice
  JOURNAL   Nat Commun 16 (1), 5772 (2025)
   PUBMED   40593679
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 622)
  AUTHORS   Piantadosi,S.C., Lee,M.K., Wu,M., Huynh,H., Avila,R.,
            Zamorano,C.A., Pizzano,C., Wu,Y., Xavier,R., Stanslaski,M.,
            Kang,J., Thai,S., Kim,Y., Zhang,J., Huang,Y., Kozorovitskiy,Y.,
            Good,C.H., Banks,A.R., Rogers,J.A. and Bruchas,M.R.
  TITLE     An integrated microfluidic and fluorescence platform for probing in
            vivo neuropharmacology
  JOURNAL   Neuron 113 (10), 1491-1506 (2025)
   PUBMED   40215966
REFERENCE   5  (residues 1 to 622)
  AUTHORS   Lefton,K.B., Wu,Y., Dai,Y., Okuda,T., Zhang,Y., Yen,A., Rurak,G.M.,
            Walsh,S., Manno,R., Myagmar,B.E., Dougherty,J.D., Samineni,V.K.,
            Simpson,P.C. and Papouin,T.
  TITLE     Norepinephrine signals through astrocytes to modulate synapses
  JOURNAL   Science 388 (6748), 776-783 (2025)
   PUBMED   40373122
REFERENCE   6  (residues 1 to 622)
  AUTHORS   Shi,Y., Alin,K. and Goff,S.P.
  TITLE     Abl-interactor-1, a novel SH3 protein binding to the
            carboxy-terminal portion of the Abl protein, suppresses v-abl
            transforming activity
  JOURNAL   Genes Dev 9 (21), 2583-2597 (1995)
   PUBMED   7590237
REFERENCE   7  (residues 1 to 622)
  AUTHORS   Compagnone,N.A., Bulfone,A., Rubenstein,J.L. and Mellon,S.H.
  TITLE     Steroidogenic enzyme P450c17 is expressed in the embryonic central
            nervous system
  JOURNAL   Endocrinology 136 (11), 5212-5223 (1995)
   PUBMED   7588260
REFERENCE   8  (residues 1 to 622)
  AUTHORS   Narisawa,S., Hasegawa,H., Watanabe,K. and Millan,J.L.
  TITLE     Stage-specific expression of alkaline phosphatase during neural
            development in the mouse
  JOURNAL   Dev Dyn 201 (3), 227-235 (1994)
   PUBMED   7533563
REFERENCE   9  (residues 1 to 622)
  AUTHORS   Nakano,T., Kobayashi,K., Saito,S., Fujita,K. and Nagatsu,T.
  TITLE     Mouse dopamine beta-hydroxylase: primary structure deduced from the
            cDNA sequence and exon/intron organization of the gene
  JOURNAL   Biochem Biophys Res Commun 189 (1), 590-599 (1992)
   PUBMED   1280432
REFERENCE   10 (residues 1 to 622)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132245.1 and BB109310.1.
            
            On Jul 28, 2006 this sequence version replaced NP_620392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132245.1, S50200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.29 cM"
     Protein         1..622
                     /product="dopamine beta-hydroxylase"
                     /EC_number="1.14.17.1"
                     /note="dopamine beta-monooxygenase"
                     /calculated_mol_wt=70183
     Site            21..41
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64237.2)"
     Site            43..44
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000250|UniProtKB:P15101;
                     propagated from UniProtKB/Swiss-Prot (Q64237.2)"
     Region          63..176
                     /region_name="DOMON"
                     /note="DOMON domain; pfam03351"
                     /db_xref="CDD:460893"
     Site            68
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64237.2)"
     Site            188
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64237.2)"
     Region          218..341
                     /region_name="Cu2_monooxygen"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     N-terminal domain; pfam01082"
                     /db_xref="CDD:460053"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q64237.2)"
     Region          364..520
                     /region_name="Cu2_monoox_C"
                     /note="Copper type II ascorbate-dependent monooxygenase,
                     C-terminal domain; pfam03712"
                     /db_xref="CDD:461021"
     Site            476
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64237.2)"
     Site            570
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64237.2)"
     Region          594..622
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64237.2)"
     CDS             1..622
                     /gene="Dbh"
                     /coded_by="NM_138942.3:10..1878"
                     /db_xref="CCDS:CCDS38088.1"
                     /db_xref="GeneID:13166"
                     /db_xref="MGI:MGI:94864"
ORIGIN      
        1 mqahlshqpc wsslpspsvr eaasmygtav aiflvilvaa lrgseppesp fpyhipldpe
       61 gilelswnvs yvqeiihfql qvqglragvl fgmsdrgeme nadlimlwtd gdrayfadaw
      121 sdrkgqihld sqqdyqllqa qrtrdglsll fkrpfvtcdp kdyvieddtv hlvygileep
      181 fqsleaints glhtglqrvq llksevptps mpedvqtmdi rapdilipdn ettywcyite
      241 lpprfprhhi imyeaivteg nealvhhmev fqcaaesedf pqfngpcdsk mkpdrlnycr
      301 hvlaawalga kafyypkeag vpfggpgssp flrlevhyhn prkiqgrqds sgirlhytat
      361 lrrydagime lglvytplma ippqetafvl tgyctdkctq malqdsgihi fasqlhthlt
      421 grkvvtvlar dgqerkvvnr dnhysphfqe irmlkkvvtv ypgdvlitsc tyntenktla
      481 tvggfgilee mcvnyvhyyp qtelelcksa vddgflqkyf hmvnrfssee vctcpqasvp
      541 qqfssvpwns fnrdmlkaly dyapismhcn ktsavrfpge wnlqplpkit stleeptprc
      601 pirqtqspan ptvpittead ae
//
LOCUS       NP_005297                330 aa            linear   PRI 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Homo sapiens].
ACCESSION   NP_005297 XP_016882198
VERSION     NP_005297.1
DBSOURCE    REFSEQ: accession NM_005306.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Buchynskyi,M., Oksenych,V., Kamyshna,I., Vorobets,I., Halabitska,I.
            and Kamyshnyi,O.
  TITLE     Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in
            Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes
  JOURNAL   Viruses 16 (6), 985 (2024)
   PUBMED   38932276
  REMARK    GeneRIF: Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene
            Expression in Metabolic-Associated Fatty Liver Disease and COVID-19
            Outcomes.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Ruhnke,N., Beyer,A.L., Kaemmerer,D., Sanger,J., Schulz,S. and
            Lupp,A.
  TITLE     Expression of free fatty acid receptor 2 in normal and neoplastic
            tissues
  JOURNAL   Exp Mol Pathol 137, 104902 (2024)
   PUBMED   38788249
  REMARK    GeneRIF: Expression of free fatty acid receptor 2 in normal and
            neoplastic tissues.
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Fang,C., Zuo,K., Liu,Z., Xu,L. and Yang,X.
  TITLE     Disordered GPR43/NLRP3 expression in peripheral leukocytes of
            patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels
  JOURNAL   Eur J Med Res 29 (1), 233 (2024)
   PUBMED   38622672
  REMARK    GeneRIF: Disordered GPR43/NLRP3 expression in peripheral leukocytes
            of patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Wu,J., Chen,N., Grau,E., Johnson,L., Liu,Y., Li,C., Scott,P.A.,
            Kim,C., Sun,D., Kaplan,H.J. and Shao,H.
  TITLE     Short chain fatty acids inhibit corneal inflammatory responses to
            TLR ligands via the ocular G-protein coupled receptor 43
  JOURNAL   Ocul Surf 32, 48-57 (2024)
   PUBMED   38224777
  REMARK    GeneRIF: Short chain fatty acids inhibit corneal inflammatory
            responses to TLR ligands via the ocular G-protein coupled receptor
            43.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Barki,N., Jenkins,L., Marsango,S., Dedeo,D., Bolognini,D.,
            Dwomoh,L., Abdelmalik,A.M., Nilsen,M., Stoffels,M., Nagel,F.,
            Schulz,S., Tobin,A.B. and Milligan,G.
  TITLE     Phosphorylation bar-coding of free fatty acid receptor 2 is
            generated in a tissue-specific manner
  JOURNAL   Elife 12, 91861 (2023)
   PUBMED   38085667
  REMARK    GeneRIF: Phosphorylation bar-coding of free fatty acid receptor 2
            is generated in a tissue-specific manner.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Brown,A.J., Jupe,S. and Briscoe,C.P.
  TITLE     A family of fatty acid binding receptors
  JOURNAL   DNA Cell Biol 24 (1), 54-61 (2005)
   PUBMED   15684720
  REMARK    Review article
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Le Poul,E., Loison,C., Struyf,S., Springael,J.Y., Lannoy,V.,
            Decobecq,M.E., Brezillon,S., Dupriez,V., Vassart,G., Van Damme,J.,
            Parmentier,M. and Detheux,M.
  TITLE     Functional characterization of human receptors for short chain
            fatty acids and their role in polymorphonuclear cell activation
  JOURNAL   J Biol Chem 278 (28), 25481-25489 (2003)
   PUBMED   12711604
  REMARK    GeneRIF: the highly selective expression of GPR43 in leukocytes,
            particularly polymorphonuclear cells, suggests a role in the
            recruitment of these cell populations toward sites of bacterial
            infection
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
  REMARK    GeneRIF: FFA2R is expressed on leukocytes and activated by
            short-chain fatty acids.
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Sawzdargo,M., George,S.R., Nguyen,T., Xu,S., Kolakowski,L.F. and
            O'Dowd,B.F.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002511.1.
            
            On Apr 26, 2019 this sequence version replaced XP_016882198.1.
            
            Summary: This gene encodes a member of the GP40 family of G
            protein-coupled receptors that are clustered together on chromosome
            19. The encoded protein is a receptor for short chain free fatty
            acids and may be involved in the inflammatory response and in
            regulating lipid plasma levels. [provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.264057.1,
                                           SRR1163657.295167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="free fatty acid activated receptor 2; G-protein
                     coupled receptor 43; fatty acid receptor 2"
                     /calculated_mol_wt=37013
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            13..33
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Site            42..62
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Site            85..105
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O15552.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O15552.1)"
     Site            174..194
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          299..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     CDS             1..330
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /coded_by="NM_005306.3:248..1240"
                     /db_xref="CCDS:CCDS12461.1"
                     /db_xref="GeneID:2867"
                     /db_xref="HGNC:HGNC:4501"
                     /db_xref="MIM:603823"
ORIGIN      
        1 mlpdwkssli lmayiiiflt glpanllalr afvgrirqpq papvhillls ltladlllll
       61 llpfkiieaa snfrwylpkv vcaltsfgfy ssiycstwll agisierylg vafpvqykls
      121 rrplygviaa lvawvmsfgh ctiviivqyl ntteqvrsgn eitcyenftd nqldvvlpvr
      181 lelclvlffi pmavtifcyw rfvwimlsqp lvgaqrrrra vglavvtlln flvcfgpynv
      241 shlvgyhqrk spwwrsiavv fsslnasldp llfyfsssvv rrafgrglqv lrnqgssllg
      301 rrgkdtaegt nedrgvgqge gmpssdftte
//
LOCUS       NP_001177750             425 aa            linear   PRI 23-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 7 isoform 2 [Homo sapiens].
ACCESSION   NP_001177750
VERSION     NP_001177750.1
DBSOURCE    REFSEQ: accession NM_001190821.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 425)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   2  (residues 1 to 425)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (residues 1 to 425)
  AUTHORS   Dai,T., Qiu,S., Gao,X., Zhao,C., Ge,Z., Yang,Y., Tang,C. and
            Feng,S.
  TITLE     Circular RNA circWNK1 inhibits the progression of gastric cancer
            via regulating the miR-21-3p/SMAD7 axis
  JOURNAL   Cancer Sci 115 (3), 974-988 (2024)
   PUBMED   38287200
  REMARK    GeneRIF: Circular RNA circWNK1 inhibits the progression of gastric
            cancer via regulating the miR-21-3p/SMAD7 axis.
REFERENCE   4  (residues 1 to 425)
  AUTHORS   Liang,S., Zheng,R., Zuo,B., Li,J., Wang,Y., Han,Y., Dong,H.,
            Zhao,X., Zhang,Y., Wang,P., Meng,R., Jia,L., Yang,A. and Yan,B.
  TITLE     SMAD7 expression in CAR-T cells improves persistence and safety for
            solid tumors
  JOURNAL   Cell Mol Immunol 21 (3), 213-226 (2024)
   PUBMED   38177245
  REMARK    GeneRIF: SMAD7 expression in CAR-T cells improves persistence and
            safety for solid tumors.
REFERENCE   5  (residues 1 to 425)
  AUTHORS   Wu,Y., Xu,J., Tan,B., Yi,T., Liu,S., Yang,G., Li,K. and Zhao,X.
  TITLE     SMAD7 gene polymorphisms and their influence on patients with
            colorectal cancer
  JOURNAL   Cell Cycle 22 (21-22), 2424-2435 (2023)
   PUBMED   38146644
  REMARK    GeneRIF: SMAD7 gene polymorphisms and their influence on patients
            with colorectal cancer.
REFERENCE   6  (residues 1 to 425)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (residues 1 to 425)
  AUTHORS   Roijer,E., Moren,A., ten Dijke,P. and Stenman,G.
  TITLE     Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1
            by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 189-190 (1998)
   PUBMED   9730599
REFERENCE   8  (residues 1 to 425)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   9  (residues 1 to 425)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
REFERENCE   10 (residues 1 to 425)
  AUTHORS   Hayashi,H., Abdollah,S., Qiu,Y., Cai,J., Xu,Y.Y., Grinnell,B.W.,
            Richardson,M.A., Topper,J.N., Gimbrone,M.A. Jr., Wrana,J.L. and
            Falb,D.
  TITLE     The MAD-related protein Smad7 associates with the TGFbeta receptor
            and functions as an antagonist of TGFbeta signaling
  JOURNAL   Cell 89 (7), 1165-1173 (1997)
   PUBMED   9215638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114684.10.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex
            translocates to the cytoplasm, where it interacts with TGF-beta
            receptor type-1 (TGFBR1), leading to the degradation of both the
            encoded protein and TGFBR1. Expression of this gene is induced by
            TGFBR1. Variations in this gene are a cause of susceptibility to
            colorectal cancer type 3 (CRCS3). Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is 1 aa
            shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.16426.1,
                                           SRR18074968.893614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     Protein         1..425
                     /product="mothers against decapentaplegic homolog 7
                     isoform 2"
                     /note="Mothers against decapentaplegic, drosophila,
                     homolog of, 7; MAD (mothers against decapentaplegic,
                     Drosophila) homolog 7; hSMAD7; MAD homolog 8; mothers
                     against DPP homolog 8; SMAD, mothers against DPP homolog
                     7"
                     /calculated_mol_wt=46224
     Region          13..55
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Region          60..205
                     /region_name="MH1_SMAD_7"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD7;
                     cd10494"
                     /db_xref="CDD:199818"
     Site            64
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:12408818; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Site            70
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:12408818; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Site            order(94,98,101,135..136,171)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199818"
     Site            order(125,180,192,197)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199818"
     Region          208..217
                     /region_name="Important for interaction with SMURF2"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Region          208..211
                     /region_name="PY-motif"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O35253,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Region          253..423
                     /region_name="MH2_SMAD_7"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD7;
                     cd10500"
                     /db_xref="CDD:199825"
     Site            order(266,274..275,277,286..290,294,298,300..301,303,310,
                     314..315,317,388,412,419,421,423)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:199825"
     CDS             1..425
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /coded_by="NM_001190821.2:542..1819"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS59317.1"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
ORIGIN      
        1 mfrtkrsalv rrlwrsrapg gedeeegagg gggggelrge gatdsrahga ggggpgragc
       61 clgkavrgak ghhhphppaa gagaaggaea dlkalthsvl kklkerqlel llqavesrgg
      121 trtaclllpg rldcrlgpga pagaqpaqpp ssyslplllc kvfrwpdlrh ssevkrlccc
      181 esygkinpel vccnphhlsr lcelespppp ysrypmdflk ptdcpdavps saetggtnyl
      241 apgglsdsql llepgdrshw cvvayweekt rvgrlycvqe psldifydlp qgngfclgql
      301 nsdnksqlvq kvrskigcgi qltrevdgvw vynrssypif iksatldnpd srtllvhkvf
      361 pgfsikafdy ekayslqrpn dhefmqqpwt gftvqisfvk gwgqcytrqf isscpcwlev
      421 ifnsr
//
LOCUS       NP_001161984             330 aa            linear   ROD 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Mus musculus].
ACCESSION   NP_001161984
VERSION     NP_001161984.1
DBSOURCE    REFSEQ: accession NM_001168512.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Fachi,J.L., de Oliveira,S., Trsan,T., Penati,S., Gilfillan,S.,
            Cao,S., Ribeiro Castro,P., Fernandes,M.F., Hyrc,K.L., Liu,X.,
            Rodrigues,P.F., Bhattarai,B., Layden,B.T., Vinolo,M.A.R. and
            Colonna,M.
  TITLE     Fiber- and acetate-mediated modulation of MHC-II expression on
            intestinal epithelium protects from Clostridioides difficile
            infection
  JOURNAL   Cell Host Microbe 33 (2), 235-251 (2025)
   PUBMED   39826540
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Shimizu,H., Miyamoto,J., Hisa,K., Ohue-Kitano,R., Takada,H.,
            Yamano,M., Nishida,A., Sasahara,D., Masujima,Y., Watanabe,K.,
            Nishikawa,S., Takahashi,S., Ikeda,T., Nakajima,Y., Yoshida,N.,
            Matsuzaki,C., Kageyama,T., Hayashi,I., Matsuki,A., Akashi,R.,
            Kitahama,S., Ueyama,M., Murakami,T., Inuki,S., Irie,J.,
            Satoh-Asahara,N., Toju,H., Mori,H., Nakaoka,S., Yamashita,T.,
            Toyoda,A., Yamamoto,K., Ohno,H., Katayama,T., Itoh,H. and Kimura,I.
  TITLE     Sucrose-preferring gut microbes prevent host obesity by producing
            exopolysaccharides
  JOURNAL   Nat Commun 16 (1), 1145 (2025)
   PUBMED   39880823
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX228700.1, AC165340.3 and AK078861.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX228700.1, CX228947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /calculated_mol_wt=36993
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Site            185..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          306..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     CDS             1..330
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /coded_by="NM_001168512.1:303..1295"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
ORIGIN      
        1 mtpdwhssli ltayiliflt glpanllalr afmgrvrqpq papvhillln ltladlllll
       61 llpfriveaa snfrwylpki vcaltgfgfy ssiycstwll agismerylg vafpvqykls
      121 rrplygviaa lvawimsfgh ctiviivqyl nsteqvgten qitcyenftq eqldvvlpvr
      181 lelclvlffv pmavtifcyw rfvwimltqp hvgaqrrrra vglavvtlln flvcfgpynm
      241 shlvgfylrq spswrveavv fsslnasldp llfyfsssvv rrafgkglll irnpassmlg
      301 rgaketvegt kmdrggsqae gvqssefvte
//
LOCUS       NP_001161981             330 aa            linear   ROD 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Mus musculus].
ACCESSION   NP_001161981
VERSION     NP_001161981.1
DBSOURCE    REFSEQ: accession NM_001168509.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Fachi,J.L., de Oliveira,S., Trsan,T., Penati,S., Gilfillan,S.,
            Cao,S., Ribeiro Castro,P., Fernandes,M.F., Hyrc,K.L., Liu,X.,
            Rodrigues,P.F., Bhattarai,B., Layden,B.T., Vinolo,M.A.R. and
            Colonna,M.
  TITLE     Fiber- and acetate-mediated modulation of MHC-II expression on
            intestinal epithelium protects from Clostridioides difficile
            infection
  JOURNAL   Cell Host Microbe 33 (2), 235-251 (2025)
   PUBMED   39826540
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Shimizu,H., Miyamoto,J., Hisa,K., Ohue-Kitano,R., Takada,H.,
            Yamano,M., Nishida,A., Sasahara,D., Masujima,Y., Watanabe,K.,
            Nishikawa,S., Takahashi,S., Ikeda,T., Nakajima,Y., Yoshida,N.,
            Matsuzaki,C., Kageyama,T., Hayashi,I., Matsuki,A., Akashi,R.,
            Kitahama,S., Ueyama,M., Murakami,T., Inuki,S., Irie,J.,
            Satoh-Asahara,N., Toju,H., Mori,H., Nakaoka,S., Yamashita,T.,
            Toyoda,A., Yamamoto,K., Ohno,H., Katayama,T., Itoh,H. and Kimura,I.
  TITLE     Sucrose-preferring gut microbes prevent host obesity by producing
            exopolysaccharides
  JOURNAL   Nat Commun 16 (1), 1145 (2025)
   PUBMED   39880823
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI607149.1 and AK078861.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI607149.1, AF545043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /calculated_mol_wt=36993
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Site            185..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          306..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     CDS             1..330
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /coded_by="NM_001168509.1:213..1205"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
ORIGIN      
        1 mtpdwhssli ltayiliflt glpanllalr afmgrvrqpq papvhillln ltladlllll
       61 llpfriveaa snfrwylpki vcaltgfgfy ssiycstwll agismerylg vafpvqykls
      121 rrplygviaa lvawimsfgh ctiviivqyl nsteqvgten qitcyenftq eqldvvlpvr
      181 lelclvlffv pmavtifcyw rfvwimltqp hvgaqrrrra vglavvtlln flvcfgpynm
      241 shlvgfylrq spswrveavv fsslnasldp llfyfsssvv rrafgkglll irnpassmlg
      301 rgaketvegt kmdrggsqae gvqssefvte
//
LOCUS       NP_001177752             238 aa            linear   PRI 23-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 7 isoform 4 precursor [Homo
            sapiens].
ACCESSION   NP_001177752
VERSION     NP_001177752.1
DBSOURCE    REFSEQ: accession NM_001190823.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 238)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   2  (residues 1 to 238)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (residues 1 to 238)
  AUTHORS   Dai,T., Qiu,S., Gao,X., Zhao,C., Ge,Z., Yang,Y., Tang,C. and
            Feng,S.
  TITLE     Circular RNA circWNK1 inhibits the progression of gastric cancer
            via regulating the miR-21-3p/SMAD7 axis
  JOURNAL   Cancer Sci 115 (3), 974-988 (2024)
   PUBMED   38287200
  REMARK    GeneRIF: Circular RNA circWNK1 inhibits the progression of gastric
            cancer via regulating the miR-21-3p/SMAD7 axis.
REFERENCE   4  (residues 1 to 238)
  AUTHORS   Liang,S., Zheng,R., Zuo,B., Li,J., Wang,Y., Han,Y., Dong,H.,
            Zhao,X., Zhang,Y., Wang,P., Meng,R., Jia,L., Yang,A. and Yan,B.
  TITLE     SMAD7 expression in CAR-T cells improves persistence and safety for
            solid tumors
  JOURNAL   Cell Mol Immunol 21 (3), 213-226 (2024)
   PUBMED   38177245
  REMARK    GeneRIF: SMAD7 expression in CAR-T cells improves persistence and
            safety for solid tumors.
REFERENCE   5  (residues 1 to 238)
  AUTHORS   Wu,Y., Xu,J., Tan,B., Yi,T., Liu,S., Yang,G., Li,K. and Zhao,X.
  TITLE     SMAD7 gene polymorphisms and their influence on patients with
            colorectal cancer
  JOURNAL   Cell Cycle 22 (21-22), 2424-2435 (2023)
   PUBMED   38146644
  REMARK    GeneRIF: SMAD7 gene polymorphisms and their influence on patients
            with colorectal cancer.
REFERENCE   6  (residues 1 to 238)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (residues 1 to 238)
  AUTHORS   Roijer,E., Moren,A., ten Dijke,P. and Stenman,G.
  TITLE     Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1
            by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 189-190 (1998)
   PUBMED   9730599
REFERENCE   8  (residues 1 to 238)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   9  (residues 1 to 238)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
REFERENCE   10 (residues 1 to 238)
  AUTHORS   Hayashi,H., Abdollah,S., Qiu,Y., Cai,J., Xu,Y.Y., Grinnell,B.W.,
            Richardson,M.A., Topper,J.N., Gimbrone,M.A. Jr., Wrana,J.L. and
            Falb,D.
  TITLE     The MAD-related protein Smad7 associates with the TGFbeta receptor
            and functions as an antagonist of TGFbeta signaling
  JOURNAL   Cell 89 (7), 1165-1173 (1997)
   PUBMED   9215638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP363832.1, AK301535.1,
            AF010193.1 and AC114684.10.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex
            translocates to the cytoplasm, where it interacts with TGF-beta
            receptor type-1 (TGFBR1), leading to the degradation of both the
            encoded protein and TGFBR1. Expression of this gene is induced by
            TGFBR1. Variations in this gene are a cause of susceptibility to
            colorectal cancer type 3 (CRCS3). Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (4)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131394.1, BP363832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     Protein         1..238
                     /product="mothers against decapentaplegic homolog 7
                     isoform 4 precursor"
                     /note="Mothers against decapentaplegic, drosophila,
                     homolog of, 7; MAD (mothers against decapentaplegic,
                     Drosophila) homolog 7; hSMAD7; MAD homolog 8; mothers
                     against DPP homolog 8; SMAD, mothers against DPP homolog
                     7"
                     /calculated_mol_wt=22997
     sig_peptide     1..35
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3925
     Region          66..236
                     /region_name="MH2_SMAD_7"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD7;
                     cd10500"
                     /db_xref="CDD:199825"
     Site            order(79,87..88,90,99..103,107,111,113..114,116,123,
                     127..128,130,201,225,232,234,236)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:199825"
     CDS             1..238
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /coded_by="NM_001190823.2:150..866"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
ORIGIN      
        1 mcglsfmlfr aclkmdlgvf icvfisfspl fkstadcpda vpssaetggt nylapgglsd
       61 sqlllepgdr shwcvvaywe ektrvgrlyc vqepsldify dlpqgngfcl gqlnsdnksq
      121 lvqkvrskig cgiqltrevd gvwvynrssy pifiksatld npdsrtllvh kvfpgfsika
      181 fdyekayslq rpndhefmqq pwtgftvqis fvkgwgqcyt rqfisscpcw levifnsr
//
LOCUS       NP_067006                183 aa            linear   PRI 23-AUG-2025
DEFINITION  ras-related protein Rap-2c isoform 1 precursor [Homo sapiens].
ACCESSION   NP_067006 XP_005262508
VERSION     NP_067006.3
DBSOURCE    REFSEQ: accession NM_021183.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 183)
  AUTHORS   Gambi,G., Mengus,G., Davidson,G., Demesmaeker,E., Cuomo,A.,
            Bonaldi,T., Katopodi,V., Malouf,G.G., Leucci,E. and Davidson,I.
  TITLE     The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and
            Promote Resistance to MAPK Inhibition in Melanoma
  JOURNAL   Cancer Res 82 (24), 4555-4570 (2022)
   PUBMED   36214632
  REMARK    GeneRIF: The LncRNA LENOX Interacts with RAP2C to Regulate
            Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
REFERENCE   2  (residues 1 to 183)
  AUTHORS   Cao,J., Jiang,M., Ren,H. and Xu,K.
  TITLE     MicroRNA-200c-3p suppresses intervertebral disc degeneration by
            targeting RAP2C/ERK signaling
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676879
  REMARK    GeneRIF: MicroRNA200c3p suppresses intervertebral disc degeneration
            by targeting RAP2C/ERK signaling.
REFERENCE   3  (residues 1 to 183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 183)
  AUTHORS   Zhu,X., Qiu,J., Zhang,T., Yang,Y., Guo,S., Li,T., Jiang,K.,
            Zahoor,A., Deng,G. and Qiu,C.
  TITLE     MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation
            of breast cancer cells via the MAPK signaling pathway by targeting
            Rap2c
  JOURNAL   J Cell Physiol 235 (3), 2389-2402 (2020)
   PUBMED   31541458
  REMARK    GeneRIF: MicroRNA-188-5p promotes apoptosis and inhibits cell
            proliferation of breast cancer cells via the MAPK signaling pathway
            by targeting Rap2c.
REFERENCE   5  (residues 1 to 183)
  AUTHORS   Chan,L.N., Hart,C., Guo,L., Nyberg,T., Davies,B.S., Fong,L.G.,
            Young,S.G., Agnew,B.J. and Tamanoi,F.
  TITLE     A novel approach to tag and identify geranylgeranylated proteins
  JOURNAL   Electrophoresis 30 (20), 3598-3606 (2009)
   PUBMED   19784953
REFERENCE   6  (residues 1 to 183)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 183)
  AUTHORS   Lilljebjorn,H., Heidenblad,M., Nilsson,B., Lassen,C., Horvat,A.,
            Heldrup,J., Behrendtz,M., Johansson,B., Andersson,A. and
            Fioretos,T.
  TITLE     Combined high-resolution array-based comparative genomic
            hybridization and expression profiling of ETV6/RUNX1-positive acute
            lymphoblastic leukemias reveal a high incidence of cryptic Xq
            duplications and identify several putative target genes within the
            commonly gained region
  JOURNAL   Leukemia 21 (10), 2137-2144 (2007)
   PUBMED   17690704
REFERENCE   8  (residues 1 to 183)
  AUTHORS   Guo,Z., Yuan,J., Tang,W., Chen,X., Gu,X., Luo,K., Wang,Y., Wan,B.
            and Yu,L.
  TITLE     Cloning and characterization of the human gene RAP2C, a novel
            member of Ras family, which activates transcriptional activities of
            SRE
  JOURNAL   Mol Biol Rep 34 (3), 137-144 (2007)
   PUBMED   17447155
  REMARK    GeneRIF: RAP2C is a novel member of the Ras family, belonging to
            the Rap branch of small GTPase proteins and may be involved in
            SRE-mediated gene transcription.
REFERENCE   9  (residues 1 to 183)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (residues 1 to 183)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
  REMARK    GeneRIF: This work demonstrates that Rap2C is a new member of the
            Rap2 subfamily of proteins, able to bind guanine nucleotides with
            peculiar properties, and differently expressed by various
            hematopoietic subsets
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY298955.1.
            
            On or before Aug 31, 2013 this sequence version replaced
            XP_005262508.1, NP_067006.2.
            
            Summary: The protein encoded by this gene is a member of the
            Ras-related protein subfamily of the Ras GTPase superfamily.
            Members of this family are small GTPases that act as molecular
            switches to regulate cellular proliferation, differentiation, and
            apoptosis. This protein has been reported to activate in vitro
            transcriptional activity of the serum response element. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY298955.1, BC051467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     Protein         1..183
                     /product="ras-related protein Rap-2c isoform 1 precursor"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein Rap-2c; small GTPase RAP2C"
                     /calculated_mol_wt=20614
     mat_peptide     1..180
                     /product="Ras-related protein Rap-2c. /id=PRO_0000030221"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y3L5.1)"
                     /calculated_mol_wt=20418
     Region          3..165
                     /region_name="Rap2"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; cd04176"
                     /db_xref="CDD:133376"
     Site            10..17
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133376"
     Site            order(11..12,59..60)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133376"
     Site            order(13..18,28..31,116..117,119,146..147)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:133376"
     Site            order(17..18,32,34,40..41,54..55,57,59..60,148)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133376"
     Site            order(25,31,33,36..41)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     Region          32..40
                     /region_name="Effector region. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y3L5.1)"
     Site            33..40
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:133376"
     Site            35
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133376"
     Site            57..60
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:133376"
     Site            order(59..65,68..73,76..77)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:133376"
     Site            116..119
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133376"
     Site            146..148
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133376"
     Site            180
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:Q8BU31; propagated from
                     UniProtKB/Swiss-Prot (Q9Y3L5.1)"
     CDS             1..183
                     /gene="RAP2C"
                     /coded_by="NM_021183.5:657..1208"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS14632.1"
                     /db_xref="GeneID:57826"
                     /db_xref="HGNC:HGNC:21165"
                     /db_xref="MIM:301016"
ORIGIN      
        1 mreykvvvlg sggvgksalt vqfvtgtfie kydptiedfy rkeievdssp svleildtag
       61 teqfasmrdl yikngqgfil vyslvnqqsf qdikpmrdqi vrvkryekvp lilvgnkvdl
      121 eperevmsse gralaqewgc pfmetsaksk smvdelfaei vrqmnysslp ekqdqccttc
      181 vvq
//
LOCUS       NP_775961                629 aa            linear   PRI 23-AUG-2025
DEFINITION  protein SCAI isoform 1 [Homo sapiens].
ACCESSION   NP_775961
VERSION     NP_775961.2
DBSOURCE    REFSEQ: accession NM_173690.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 629)
  AUTHORS   Wang,X., Liu,Z., Chu,A., Song,R., Liu,S., Chai,T. and Sun,C.
  TITLE     Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI
  JOURNAL   J Bioenerg Biomembr 55 (5), 381-396 (2023)
   PUBMED   37743442
  REMARK    GeneRIF: Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI.
REFERENCE   2  (residues 1 to 629)
  AUTHORS   Anuchina,A.A., Zaynitdinova,M.I., Demchenko,A.G., Evtushenko,N.A.,
            Lavrov,A.V. and Smirnikhina,S.A.
  TITLE     Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and
            SCR7
  JOURNAL   Int J Mol Sci 24 (7), 6704 (2023)
   PUBMED   37047677
  REMARK    GeneRIF: Bridging Gaps in HDR Improvement: The Role of MAD2L2,
            SCAI, and SCR7.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 629)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   4  (residues 1 to 629)
  AUTHORS   Luo,X., Zhang,X., Peng,J., Chen,Y., Zhao,W., Jiang,X., Su,L.,
            Xie,M. and Lin,B.
  TITLE     miR-371b-5p promotes cell proliferation, migration and invasion in
            non-small cell lung cancer via SCAI
  JOURNAL   Biosci Rep 40 (11) (2020)
   PUBMED   33103723
  REMARK    GeneRIF: miR-371b-5p promotes cell proliferation, migration and
            invasion in non-small cell lung cancer via SCAI.
REFERENCE   5  (residues 1 to 629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 629)
  AUTHORS   Lin,L., Liu,D., Liang,H., Xue,L., Su,C. and Liu,M.
  TITLE     MiR-1228 promotes breast cancer cell growth and metastasis through
            targeting SCAI protein
  JOURNAL   Int J Clin Exp Pathol 8 (6), 6646-6655 (2015)
   PUBMED   26261546
  REMARK    GeneRIF: miR-1228 promoted breast cancer proliferation, invasion
            and migration was mediated by MOAP1 and SCAI.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 629)
  AUTHORS   Chen,X., Hu,W., Xie,B., Gao,H., Xu,C. and Chen,J.
  TITLE     Downregulation of SCAI enhances glioma cell invasion and stem cell
            like phenotype by activating Wnt/beta-catenin signaling
  JOURNAL   Biochem Biophys Res Commun 448 (2), 206-211 (2014)
   PUBMED   24785374
  REMARK    GeneRIF: Downregulation of SCAI enhances glioma cell invasion and
            cancer stem cell like phenotype.Downregulation of SCAI activates
            the Wnt/beta-catenin signaling.
REFERENCE   8  (residues 1 to 629)
  AUTHORS   Brauchle,M., Yao,Z., Arora,R., Thigale,S., Clay,I., Inverardi,B.,
            Fletcher,J., Taslimi,P., Acker,M.G., Gerrits,B., Voshol,J.,
            Bauer,A., Schubeler,D., Bouwmeester,T. and Ruffner,H.
  TITLE     Protein complex interactor analysis and differential activity of
            KDM3 subfamily members towards H3K9 methylation
  JOURNAL   PLoS One 8 (4), e60549 (2013)
   PUBMED   23593242
  REMARK    GeneRIF: SCAI is a specific interaction partner for KMD3B.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 629)
  AUTHORS   Fintha,A., Gasparics,A., Fang,L., Erdei,Z., Hamar,P., Mozes,M.M.,
            Kokeny,G., Rosivall,L. and Sebe,A.
  TITLE     Characterization and role of SCAI during renal fibrosis and
            epithelial-to-mesenchymal transition
  JOURNAL   Am J Pathol 182 (2), 388-400 (2013)
   PUBMED   23178076
  REMARK    GeneRIF: SCAI is a novel transcriptional cofactor that regulates
            epithelial-to-mesenchymal transition and renal fibrosis.
REFERENCE   10 (residues 1 to 629)
  AUTHORS   Brandt,D.T., Baarlink,C., Kitzing,T.M., Kremmer,E., Ivaska,J.,
            Nollau,P. and Grosse,R.
  TITLE     SCAI acts as a suppressor of cancer cell invasion through the
            transcriptional control of beta1-integrin
  JOURNAL   Nat Cell Biol 11 (5), 557-568 (2009)
   PUBMED   19350017
  REMARK    GeneRIF: Genome-wide expression analysis surprisingly reveals that
            one of the strongest upregulated genes after suppression of SCAI is
            beta1-integrin
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB048788.1, BC104030.2,
            AL451125.7 and BM873972.1.
            
            On Oct 18, 2006 this sequence version replaced NP_775961.1.
            
            Summary: This gene encodes a regulator of cell migration. The
            encoded protein appears to function in the RhoA (ras homolog gene
            family, member A)-Dia1 (diaphanous homolog 1) signal transduction
            pathway. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1574116.1, BC104030.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     Protein         1..629
                     /product="protein SCAI isoform 1"
                     /note="protein SCAI; suppressor of cancer cell invasion
                     protein"
                     /calculated_mol_wt=72803
     Region          87..580
                     /region_name="SCAI"
                     /note="Protein SCAI; pfam12070"
                     /db_xref="CDD:463455"
     CDS             1..629
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /coded_by="NM_173690.5:92..1981"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS43877.1"
                     /db_xref="GeneID:286205"
                     /db_xref="HGNC:HGNC:26709"
                     /db_xref="MIM:619222"
ORIGIN      
        1 mvrgarqpqq prsrlaprlt gtvekpprkr rssirgsgds shsqsqgery qhftektefa
       61 lkeimssgga eddipqgerk tvtdfcylld kskqlfnglr dlpqygqkqw qsyfgrtfdv
      121 ytklwkfqqq hrqvldnryg lkrwqigeia skigqlyyhy ylrtsetsyl neafsfysai
      181 rqrsyysqvn kedrpelvvk klryyarfiv vclllnkmdv vkdlvkelsd eiedythrfn
      241 tedqvewnlv lqevaafiea dpvmvlnddn tivitsnrla etgaplleqg mivgqlslad
      301 aliigncnnq vkfseltvdm frmlqalere pmnlasqmnk pgmqesadkp trrenphkyl
      361 lykptfsqly tflaasfkel pansvlliyl satgvfptgr sdsegpydfg gvltnsnrdi
      421 ingdaihkrn qshkemhclh pgdlypftrk plfiivdssn svayknftnl fgqplvclls
      481 ptaypkalqd qsqrgslftl flnnplmafl fvsglssmrr glwekcqeyl rkinrdiaql
      541 lthsrsidqa flqffgdefl rllltrfifc satmrmhkif retrnypesy pqlprdetve
      601 nphlqkhile lasildvrnv ffentiddy
//
LOCUS       NP_001138349             606 aa            linear   PRI 23-AUG-2025
DEFINITION  protein SCAI isoform 2 [Homo sapiens].
ACCESSION   NP_001138349
VERSION     NP_001138349.1
DBSOURCE    REFSEQ: accession NM_001144877.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 606)
  AUTHORS   Wang,X., Liu,Z., Chu,A., Song,R., Liu,S., Chai,T. and Sun,C.
  TITLE     Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI
  JOURNAL   J Bioenerg Biomembr 55 (5), 381-396 (2023)
   PUBMED   37743442
  REMARK    GeneRIF: Hsa_circ_0052611 and mir-767-5p guide the warburg effect,
            migration, and invasion of BRCA cells through modulating SCAI.
REFERENCE   2  (residues 1 to 606)
  AUTHORS   Anuchina,A.A., Zaynitdinova,M.I., Demchenko,A.G., Evtushenko,N.A.,
            Lavrov,A.V. and Smirnikhina,S.A.
  TITLE     Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and
            SCR7
  JOURNAL   Int J Mol Sci 24 (7), 6704 (2023)
   PUBMED   37047677
  REMARK    GeneRIF: Bridging Gaps in HDR Improvement: The Role of MAD2L2,
            SCAI, and SCR7.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 606)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   4  (residues 1 to 606)
  AUTHORS   Luo,X., Zhang,X., Peng,J., Chen,Y., Zhao,W., Jiang,X., Su,L.,
            Xie,M. and Lin,B.
  TITLE     miR-371b-5p promotes cell proliferation, migration and invasion in
            non-small cell lung cancer via SCAI
  JOURNAL   Biosci Rep 40 (11) (2020)
   PUBMED   33103723
  REMARK    GeneRIF: miR-371b-5p promotes cell proliferation, migration and
            invasion in non-small cell lung cancer via SCAI.
REFERENCE   5  (residues 1 to 606)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 606)
  AUTHORS   Lin,L., Liu,D., Liang,H., Xue,L., Su,C. and Liu,M.
  TITLE     MiR-1228 promotes breast cancer cell growth and metastasis through
            targeting SCAI protein
  JOURNAL   Int J Clin Exp Pathol 8 (6), 6646-6655 (2015)
   PUBMED   26261546
  REMARK    GeneRIF: miR-1228 promoted breast cancer proliferation, invasion
            and migration was mediated by MOAP1 and SCAI.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 606)
  AUTHORS   Chen,X., Hu,W., Xie,B., Gao,H., Xu,C. and Chen,J.
  TITLE     Downregulation of SCAI enhances glioma cell invasion and stem cell
            like phenotype by activating Wnt/beta-catenin signaling
  JOURNAL   Biochem Biophys Res Commun 448 (2), 206-211 (2014)
   PUBMED   24785374
  REMARK    GeneRIF: Downregulation of SCAI enhances glioma cell invasion and
            cancer stem cell like phenotype.Downregulation of SCAI activates
            the Wnt/beta-catenin signaling.
REFERENCE   8  (residues 1 to 606)
  AUTHORS   Brauchle,M., Yao,Z., Arora,R., Thigale,S., Clay,I., Inverardi,B.,
            Fletcher,J., Taslimi,P., Acker,M.G., Gerrits,B., Voshol,J.,
            Bauer,A., Schubeler,D., Bouwmeester,T. and Ruffner,H.
  TITLE     Protein complex interactor analysis and differential activity of
            KDM3 subfamily members towards H3K9 methylation
  JOURNAL   PLoS One 8 (4), e60549 (2013)
   PUBMED   23593242
  REMARK    GeneRIF: SCAI is a specific interaction partner for KMD3B.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 606)
  AUTHORS   Fintha,A., Gasparics,A., Fang,L., Erdei,Z., Hamar,P., Mozes,M.M.,
            Kokeny,G., Rosivall,L. and Sebe,A.
  TITLE     Characterization and role of SCAI during renal fibrosis and
            epithelial-to-mesenchymal transition
  JOURNAL   Am J Pathol 182 (2), 388-400 (2013)
   PUBMED   23178076
  REMARK    GeneRIF: SCAI is a novel transcriptional cofactor that regulates
            epithelial-to-mesenchymal transition and renal fibrosis.
REFERENCE   10 (residues 1 to 606)
  AUTHORS   Brandt,D.T., Baarlink,C., Kitzing,T.M., Kremmer,E., Ivaska,J.,
            Nollau,P. and Grosse,R.
  TITLE     SCAI acts as a suppressor of cancer cell invasion through the
            transcriptional control of beta1-integrin
  JOURNAL   Nat Cell Biol 11 (5), 557-568 (2009)
   PUBMED   19350017
  REMARK    GeneRIF: Genome-wide expression analysis surprisingly reveals that
            one of the strongest upregulated genes after suppression of SCAI is
            beta1-integrin
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB048788.1, BC104031.1,
            AL451125.7 and BM873972.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a regulator of cell migration. The
            encoded protein appears to function in the RhoA (ras homolog gene
            family, member A)-Dia1 (diaphanous homolog 1) signal transduction
            pathway. Alternatively spliced transcript variants have been
            described. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1208117.1,
                                           SRR11853567.30856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336505.11/ ENSP00000336756.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     Protein         1..606
                     /product="protein SCAI isoform 2"
                     /note="protein SCAI; suppressor of cancer cell invasion
                     protein"
                     /calculated_mol_wt=70269
     Region          1..212
                     /region_name="Necessary to inhibit MRTFA-induced SRF
                     transcriptional activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N9R8.2)"
     Region          1..35
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N9R8.2)"
     Region          64..557
                     /region_name="SCAI"
                     /note="Protein SCAI; pfam12070"
                     /db_xref="CDD:463455"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q8C8N2; propagated from
                     UniProtKB/Swiss-Prot (Q8N9R8.2)"
     Region          71..173
                     /region_name="Required for interaction with MRTFA.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N9R8.2)"
     Site            472..492
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N9R8.2)"
     CDS             1..606
                     /gene="SCAI"
                     /gene_synonym="C9orf126; NET40"
                     /coded_by="NM_001144877.3:92..1912"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48017.1"
                     /db_xref="GeneID:286205"
                     /db_xref="HGNC:HGNC:26709"
                     /db_xref="MIM:619222"
ORIGIN      
        1 mvrgarqpqq prsrlaprlt gtvekpprkr rsrtefalke imssggaedd ipqgerktvt
       61 dfcylldksk qlfnglrdlp qygqkqwqsy fgrtfdvytk lwkfqqqhrq vldnryglkr
      121 wqigeiaski gqlyyhyylr tsetsylnea fsfysairqr syysqvnked rpelvvkklr
      181 yyarfivvcl llnkmdvvkd lvkelsdeie dythrfnted qvewnlvlqe vaafieadpv
      241 mvlnddntiv itsnrlaetg aplleqgmiv gqlsladali igncnnqvkf seltvdmfrm
      301 lqalerepmn lasqmnkpgm qesadkptrr enphkyllyk ptfsqlytfl aasfkelpan
      361 svlliylsat gvfptgrsds egpydfggvl tnsnrdiing daihkrnqsh kemhclhpgd
      421 lypftrkplf iivdssnsva yknftnlfgq plvcllspta ypkalqdqsq rgslftlfln
      481 nplmaflfvs glssmrrglw ekcqeylrki nrdiaqllth srsidqaflq ffgdeflrll
      541 ltrfifcsat mrmhkifret rnypesypql prdetvenph lqkhilelas ildvrnvffe
      601 ntiddy
//
LOCUS       NP_001258116             117 aa            linear   PRI 23-AUG-2025
DEFINITION  ras-related protein Rap-2c isoform 2 [Homo sapiens].
ACCESSION   NP_001258116
VERSION     NP_001258116.1
DBSOURCE    REFSEQ: accession NM_001271187.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 117)
  AUTHORS   Gambi,G., Mengus,G., Davidson,G., Demesmaeker,E., Cuomo,A.,
            Bonaldi,T., Katopodi,V., Malouf,G.G., Leucci,E. and Davidson,I.
  TITLE     The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and
            Promote Resistance to MAPK Inhibition in Melanoma
  JOURNAL   Cancer Res 82 (24), 4555-4570 (2022)
   PUBMED   36214632
  REMARK    GeneRIF: The LncRNA LENOX Interacts with RAP2C to Regulate
            Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
REFERENCE   2  (residues 1 to 117)
  AUTHORS   Cao,J., Jiang,M., Ren,H. and Xu,K.
  TITLE     MicroRNA-200c-3p suppresses intervertebral disc degeneration by
            targeting RAP2C/ERK signaling
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676879
  REMARK    GeneRIF: MicroRNA200c3p suppresses intervertebral disc degeneration
            by targeting RAP2C/ERK signaling.
REFERENCE   3  (residues 1 to 117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 117)
  AUTHORS   Zhu,X., Qiu,J., Zhang,T., Yang,Y., Guo,S., Li,T., Jiang,K.,
            Zahoor,A., Deng,G. and Qiu,C.
  TITLE     MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation
            of breast cancer cells via the MAPK signaling pathway by targeting
            Rap2c
  JOURNAL   J Cell Physiol 235 (3), 2389-2402 (2020)
   PUBMED   31541458
  REMARK    GeneRIF: MicroRNA-188-5p promotes apoptosis and inhibits cell
            proliferation of breast cancer cells via the MAPK signaling pathway
            by targeting Rap2c.
REFERENCE   5  (residues 1 to 117)
  AUTHORS   Chan,L.N., Hart,C., Guo,L., Nyberg,T., Davies,B.S., Fong,L.G.,
            Young,S.G., Agnew,B.J. and Tamanoi,F.
  TITLE     A novel approach to tag and identify geranylgeranylated proteins
  JOURNAL   Electrophoresis 30 (20), 3598-3606 (2009)
   PUBMED   19784953
REFERENCE   6  (residues 1 to 117)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 117)
  AUTHORS   Lilljebjorn,H., Heidenblad,M., Nilsson,B., Lassen,C., Horvat,A.,
            Heldrup,J., Behrendtz,M., Johansson,B., Andersson,A. and
            Fioretos,T.
  TITLE     Combined high-resolution array-based comparative genomic
            hybridization and expression profiling of ETV6/RUNX1-positive acute
            lymphoblastic leukemias reveal a high incidence of cryptic Xq
            duplications and identify several putative target genes within the
            commonly gained region
  JOURNAL   Leukemia 21 (10), 2137-2144 (2007)
   PUBMED   17690704
REFERENCE   8  (residues 1 to 117)
  AUTHORS   Guo,Z., Yuan,J., Tang,W., Chen,X., Gu,X., Luo,K., Wang,Y., Wan,B.
            and Yu,L.
  TITLE     Cloning and characterization of the human gene RAP2C, a novel
            member of Ras family, which activates transcriptional activities of
            SRE
  JOURNAL   Mol Biol Rep 34 (3), 137-144 (2007)
   PUBMED   17447155
  REMARK    GeneRIF: RAP2C is a novel member of the Ras family, belonging to
            the Rap branch of small GTPase proteins and may be involved in
            SRE-mediated gene transcription.
REFERENCE   9  (residues 1 to 117)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (residues 1 to 117)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
  REMARK    GeneRIF: This work demonstrates that Rap2C is a new member of the
            Rap2 subfamily of proteins, able to bind guanine nucleotides with
            peculiar properties, and differently expressed by various
            hematopoietic subsets
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK310997.1, BI767215.1,
            CN308919.1 and AY298955.1.
            
            Summary: The protein encoded by this gene is a member of the
            Ras-related protein subfamily of the Ras GTPase superfamily.
            Members of this family are small GTPases that act as molecular
            switches to regulate cellular proliferation, differentiation, and
            apoptosis. This protein has been reported to activate in vitro
            transcriptional activity of the serum response element. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2012].
            
            Transcript Variant: This variant (3) uses an alternate 5'
            structure, compared to variant 1. These differences cause
            translation initiation at a downstream AUG and result in an isoform
            (2) with a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2348155.1,
                                           SRR14038193.4019845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..117
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     Protein         1..117
                     /product="ras-related protein Rap-2c isoform 2"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein Rap-2c; small GTPase RAP2C"
                     /calculated_mol_wt=13382
     Region          <1..99
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            50..53
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206648"
     Site            80..82
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206648"
     CDS             1..117
                     /gene="RAP2C"
                     /coded_by="NM_001271187.2:357..710"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS76024.1"
                     /db_xref="GeneID:57826"
                     /db_xref="HGNC:HGNC:21165"
                     /db_xref="MIM:301016"
ORIGIN      
        1 mrdlyikngq gfilvyslvn qqsfqdikpm rdqivrvkry ekvplilvgn kvdleperev
       61 mssegralaq ewgcpfmets aksksmvdel faeivrqmny sslpekqdqc cttcvvq
//
LOCUS       NP_001357016             330 aa            linear   PRI 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Homo sapiens].
ACCESSION   NP_001357016 XP_016882199
VERSION     NP_001357016.1
DBSOURCE    REFSEQ: accession NM_001370087.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Buchynskyi,M., Oksenych,V., Kamyshna,I., Vorobets,I., Halabitska,I.
            and Kamyshnyi,O.
  TITLE     Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in
            Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes
  JOURNAL   Viruses 16 (6), 985 (2024)
   PUBMED   38932276
  REMARK    GeneRIF: Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene
            Expression in Metabolic-Associated Fatty Liver Disease and COVID-19
            Outcomes.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Ruhnke,N., Beyer,A.L., Kaemmerer,D., Sanger,J., Schulz,S. and
            Lupp,A.
  TITLE     Expression of free fatty acid receptor 2 in normal and neoplastic
            tissues
  JOURNAL   Exp Mol Pathol 137, 104902 (2024)
   PUBMED   38788249
  REMARK    GeneRIF: Expression of free fatty acid receptor 2 in normal and
            neoplastic tissues.
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Fang,C., Zuo,K., Liu,Z., Xu,L. and Yang,X.
  TITLE     Disordered GPR43/NLRP3 expression in peripheral leukocytes of
            patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels
  JOURNAL   Eur J Med Res 29 (1), 233 (2024)
   PUBMED   38622672
  REMARK    GeneRIF: Disordered GPR43/NLRP3 expression in peripheral leukocytes
            of patients with atrial fibrillation is associated with intestinal
            short chain fatty acids levels.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Wu,J., Chen,N., Grau,E., Johnson,L., Liu,Y., Li,C., Scott,P.A.,
            Kim,C., Sun,D., Kaplan,H.J. and Shao,H.
  TITLE     Short chain fatty acids inhibit corneal inflammatory responses to
            TLR ligands via the ocular G-protein coupled receptor 43
  JOURNAL   Ocul Surf 32, 48-57 (2024)
   PUBMED   38224777
  REMARK    GeneRIF: Short chain fatty acids inhibit corneal inflammatory
            responses to TLR ligands via the ocular G-protein coupled receptor
            43.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Barki,N., Jenkins,L., Marsango,S., Dedeo,D., Bolognini,D.,
            Dwomoh,L., Abdelmalik,A.M., Nilsen,M., Stoffels,M., Nagel,F.,
            Schulz,S., Tobin,A.B. and Milligan,G.
  TITLE     Phosphorylation bar-coding of free fatty acid receptor 2 is
            generated in a tissue-specific manner
  JOURNAL   Elife 12, 91861 (2023)
   PUBMED   38085667
  REMARK    GeneRIF: Phosphorylation bar-coding of free fatty acid receptor 2
            is generated in a tissue-specific manner.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Brown,A.J., Jupe,S. and Briscoe,C.P.
  TITLE     A family of fatty acid binding receptors
  JOURNAL   DNA Cell Biol 24 (1), 54-61 (2005)
   PUBMED   15684720
  REMARK    Review article
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Le Poul,E., Loison,C., Struyf,S., Springael,J.Y., Lannoy,V.,
            Decobecq,M.E., Brezillon,S., Dupriez,V., Vassart,G., Van Damme,J.,
            Parmentier,M. and Detheux,M.
  TITLE     Functional characterization of human receptors for short chain
            fatty acids and their role in polymorphonuclear cell activation
  JOURNAL   J Biol Chem 278 (28), 25481-25489 (2003)
   PUBMED   12711604
  REMARK    GeneRIF: the highly selective expression of GPR43 in leukocytes,
            particularly polymorphonuclear cells, suggests a role in the
            recruitment of these cell populations toward sites of bacterial
            infection
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
  REMARK    GeneRIF: FFA2R is expressed on leukocytes and activated by
            short-chain fatty acids.
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Brown,A.J., Goldsworthy,S.M., Barnes,A.A., Eilert,M.M., Tcheang,L.,
            Daniels,D., Muir,A.I., Wigglesworth,M.J., Kinghorn,I., Fraser,N.J.,
            Pike,N.B., Strum,J.C., Steplewski,K.M., Murdock,P.R., Holder,J.C.,
            Marshall,F.H., Szekeres,P.G., Wilson,S., Ignar,D.M., Foord,S.M.,
            Wise,A. and Dowell,S.J.
  TITLE     The Orphan G protein-coupled receptors GPR41 and GPR43 are
            activated by propionate and other short chain carboxylic acids
  JOURNAL   J Biol Chem 278 (13), 11312-11319 (2003)
   PUBMED   12496283
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Sawzdargo,M., George,S.R., Nguyen,T., Xu,S., Kolakowski,L.F. and
            O'Dowd,B.F.
  TITLE     A cluster of four novel human G protein-coupled receptor genes
            occurring in close proximity to CD22 gene on chromosome 19q13.1
  JOURNAL   Biochem Biophys Res Commun 239 (2), 543-547 (1997)
   PUBMED   9344866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002511.1.
            
            On Apr 26, 2019 this sequence version replaced XP_016882199.1.
            
            Summary: This gene encodes a member of the GP40 family of G
            protein-coupled receptors that are clustered together on chromosome
            19. The encoded protein is a receptor for short chain free fatty
            acids and may be involved in the inflammatory response and in
            regulating lipid plasma levels. [provided by RefSeq, Apr 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.119558.1,
                                           DRR138517.507566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599180.3/ ENSP00000473159.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="free fatty acid activated receptor 2; G-protein
                     coupled receptor 43; fatty acid receptor 2"
                     /calculated_mol_wt=37013
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            13..33
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Site            42..62
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Site            85..105
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O15552.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O15552.1)"
     Site            174..194
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     Region          299..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15552.1)"
     CDS             1..330
                     /gene="FFAR2"
                     /gene_synonym="FFA2R; GPR43"
                     /coded_by="NM_001370087.1:125..1117"
                     /db_xref="CCDS:CCDS12461.1"
                     /db_xref="GeneID:2867"
                     /db_xref="HGNC:HGNC:4501"
                     /db_xref="MIM:603823"
ORIGIN      
        1 mlpdwkssli lmayiiiflt glpanllalr afvgrirqpq papvhillls ltladlllll
       61 llpfkiieaa snfrwylpkv vcaltsfgfy ssiycstwll agisierylg vafpvqykls
      121 rrplygviaa lvawvmsfgh ctiviivqyl ntteqvrsgn eitcyenftd nqldvvlpvr
      181 lelclvlffi pmavtifcyw rfvwimlsqp lvgaqrrrra vglavvtlln flvcfgpynv
      241 shlvgyhqrk spwwrsiavv fsslnasldp llfyfsssvv rrafgrglqv lrnqgssllg
      301 rrgkdtaegt nedrgvgqge gmpssdftte
//
LOCUS       NP_001161982             330 aa            linear   ROD 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Mus musculus].
ACCESSION   NP_001161982
VERSION     NP_001161982.1
DBSOURCE    REFSEQ: accession NM_001168510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Fachi,J.L., de Oliveira,S., Trsan,T., Penati,S., Gilfillan,S.,
            Cao,S., Ribeiro Castro,P., Fernandes,M.F., Hyrc,K.L., Liu,X.,
            Rodrigues,P.F., Bhattarai,B., Layden,B.T., Vinolo,M.A.R. and
            Colonna,M.
  TITLE     Fiber- and acetate-mediated modulation of MHC-II expression on
            intestinal epithelium protects from Clostridioides difficile
            infection
  JOURNAL   Cell Host Microbe 33 (2), 235-251 (2025)
   PUBMED   39826540
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Shimizu,H., Miyamoto,J., Hisa,K., Ohue-Kitano,R., Takada,H.,
            Yamano,M., Nishida,A., Sasahara,D., Masujima,Y., Watanabe,K.,
            Nishikawa,S., Takahashi,S., Ikeda,T., Nakajima,Y., Yoshida,N.,
            Matsuzaki,C., Kageyama,T., Hayashi,I., Matsuki,A., Akashi,R.,
            Kitahama,S., Ueyama,M., Murakami,T., Inuki,S., Irie,J.,
            Satoh-Asahara,N., Toju,H., Mori,H., Nakaoka,S., Yamashita,T.,
            Toyoda,A., Yamamoto,K., Ohno,H., Katayama,T., Itoh,H. and Kimura,I.
  TITLE     Sucrose-preferring gut microbes prevent host obesity by producing
            exopolysaccharides
  JOURNAL   Nat Commun 16 (1), 1145 (2025)
   PUBMED   39880823
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI573563.1 and AK078861.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI573563.1, CX228158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /calculated_mol_wt=36993
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Site            185..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          306..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     CDS             1..330
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /coded_by="NM_001168510.1:150..1142"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
ORIGIN      
        1 mtpdwhssli ltayiliflt glpanllalr afmgrvrqpq papvhillln ltladlllll
       61 llpfriveaa snfrwylpki vcaltgfgfy ssiycstwll agismerylg vafpvqykls
      121 rrplygviaa lvawimsfgh ctiviivqyl nsteqvgten qitcyenftq eqldvvlpvr
      181 lelclvlffv pmavtifcyw rfvwimltqp hvgaqrrrra vglavvtlln flvcfgpynm
      241 shlvgfylrq spswrveavv fsslnasldp llfyfsssvv rrafgkglll irnpassmlg
      301 rgaketvegt kmdrggsqae gvqssefvte
//
LOCUS       NP_666299                330 aa            linear   ROD 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Mus musculus].
ACCESSION   NP_666299
VERSION     NP_666299.1
DBSOURCE    REFSEQ: accession NM_146187.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Fachi,J.L., de Oliveira,S., Trsan,T., Penati,S., Gilfillan,S.,
            Cao,S., Ribeiro Castro,P., Fernandes,M.F., Hyrc,K.L., Liu,X.,
            Rodrigues,P.F., Bhattarai,B., Layden,B.T., Vinolo,M.A.R. and
            Colonna,M.
  TITLE     Fiber- and acetate-mediated modulation of MHC-II expression on
            intestinal epithelium protects from Clostridioides difficile
            infection
  JOURNAL   Cell Host Microbe 33 (2), 235-251 (2025)
   PUBMED   39826540
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Shimizu,H., Miyamoto,J., Hisa,K., Ohue-Kitano,R., Takada,H.,
            Yamano,M., Nishida,A., Sasahara,D., Masujima,Y., Watanabe,K.,
            Nishikawa,S., Takahashi,S., Ikeda,T., Nakajima,Y., Yoshida,N.,
            Matsuzaki,C., Kageyama,T., Hayashi,I., Matsuki,A., Akashi,R.,
            Kitahama,S., Ueyama,M., Murakami,T., Inuki,S., Irie,J.,
            Satoh-Asahara,N., Toju,H., Mori,H., Nakaoka,S., Yamashita,T.,
            Toyoda,A., Yamamoto,K., Ohno,H., Katayama,T., Itoh,H. and Kimura,I.
  TITLE     Sucrose-preferring gut microbes prevent host obesity by producing
            exopolysaccharides
  JOURNAL   Nat Commun 16 (1), 1145 (2025)
   PUBMED   39880823
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078861.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078861.1, BB624896.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849376,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /calculated_mol_wt=36993
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Site            185..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          306..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     CDS             1..330
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /coded_by="NM_146187.4:536..1528"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
ORIGIN      
        1 mtpdwhssli ltayiliflt glpanllalr afmgrvrqpq papvhillln ltladlllll
       61 llpfriveaa snfrwylpki vcaltgfgfy ssiycstwll agismerylg vafpvqykls
      121 rrplygviaa lvawimsfgh ctiviivqyl nsteqvgten qitcyenftq eqldvvlpvr
      181 lelclvlffv pmavtifcyw rfvwimltqp hvgaqrrrra vglavvtlln flvcfgpynm
      241 shlvgfylrq spswrveavv fsslnasldp llfyfsssvv rrafgkglll irnpassmlg
      301 rgaketvegt kmdrggsqae gvqssefvte
//
LOCUS       NP_005895                426 aa            linear   PRI 23-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 7 isoform 1 [Homo sapiens].
ACCESSION   NP_005895
VERSION     NP_005895.1
DBSOURCE    REFSEQ: accession NM_005904.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Dai,T., Qiu,S., Gao,X., Zhao,C., Ge,Z., Yang,Y., Tang,C. and
            Feng,S.
  TITLE     Circular RNA circWNK1 inhibits the progression of gastric cancer
            via regulating the miR-21-3p/SMAD7 axis
  JOURNAL   Cancer Sci 115 (3), 974-988 (2024)
   PUBMED   38287200
  REMARK    GeneRIF: Circular RNA circWNK1 inhibits the progression of gastric
            cancer via regulating the miR-21-3p/SMAD7 axis.
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Liang,S., Zheng,R., Zuo,B., Li,J., Wang,Y., Han,Y., Dong,H.,
            Zhao,X., Zhang,Y., Wang,P., Meng,R., Jia,L., Yang,A. and Yan,B.
  TITLE     SMAD7 expression in CAR-T cells improves persistence and safety for
            solid tumors
  JOURNAL   Cell Mol Immunol 21 (3), 213-226 (2024)
   PUBMED   38177245
  REMARK    GeneRIF: SMAD7 expression in CAR-T cells improves persistence and
            safety for solid tumors.
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Wu,Y., Xu,J., Tan,B., Yi,T., Liu,S., Yang,G., Li,K. and Zhao,X.
  TITLE     SMAD7 gene polymorphisms and their influence on patients with
            colorectal cancer
  JOURNAL   Cell Cycle 22 (21-22), 2424-2435 (2023)
   PUBMED   38146644
  REMARK    GeneRIF: SMAD7 gene polymorphisms and their influence on patients
            with colorectal cancer.
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Roijer,E., Moren,A., ten Dijke,P. and Stenman,G.
  TITLE     Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1
            by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 189-190 (1998)
   PUBMED   9730599
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Hayashi,H., Abdollah,S., Qiu,Y., Cai,J., Xu,Y.Y., Grinnell,B.W.,
            Richardson,M.A., Topper,J.N., Gimbrone,M.A. Jr., Wrana,J.L. and
            Falb,D.
  TITLE     The MAD-related protein Smad7 associates with the TGFbeta receptor
            and functions as an antagonist of TGFbeta signaling
  JOURNAL   Cell 89 (7), 1165-1173 (1997)
   PUBMED   9215638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114684.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex
            translocates to the cytoplasm, where it interacts with TGF-beta
            receptor type-1 (TGFBR1), leading to the degradation of both the
            encoded protein and TGFBR1. Expression of this gene is induced by
            TGFBR1. Variations in this gene are a cause of susceptibility to
            colorectal cancer type 3 (CRCS3). Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF010193.1, SRR14038193.3544238.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262158.8/ ENSP00000262158.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     Protein         1..426
                     /product="mothers against decapentaplegic homolog 7
                     isoform 1"
                     /note="Mothers against decapentaplegic, drosophila,
                     homolog of, 7; MAD (mothers against decapentaplegic,
                     Drosophila) homolog 7; hSMAD7; MAD homolog 8; mothers
                     against DPP homolog 8; SMAD, mothers against DPP homolog
                     7"
                     /calculated_mol_wt=46295
     Region          13..55
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Region          60..205
                     /region_name="MH1_SMAD_7"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD7;
                     cd10494"
                     /db_xref="CDD:199818"
     Site            64
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:12408818; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Site            70
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:12408818; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Site            order(94,98,101,135..136,171)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199818"
     Site            order(125,180,192,197)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199818"
     Region          208..217
                     /region_name="Important for interaction with SMURF2"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Region          208..211
                     /region_name="PY-motif"
                     /note="propagated from UniProtKB/Swiss-Prot (O15105.1)"
     Site            249
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O35253,
                     ECO:0000255|PROSITE-ProRule:PRU00439; propagated from
                     UniProtKB/Swiss-Prot (O15105.1)"
     Region          254..424
                     /region_name="MH2_SMAD_7"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD7;
                     cd10500"
                     /db_xref="CDD:199825"
     Site            order(267,275..276,278,287..291,295,299,301..302,304,311,
                     315..316,318,389,413,420,422,424)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:199825"
     CDS             1..426
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /coded_by="NM_005904.4:542..1822"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11936.1"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
ORIGIN      
        1 mfrtkrsalv rrlwrsrapg gedeeegagg gggggelrge gatdsrahga ggggpgragc
       61 clgkavrgak ghhhphppaa gagaaggaea dlkalthsvl kklkerqlel llqavesrgg
      121 trtaclllpg rldcrlgpga pagaqpaqpp ssyslplllc kvfrwpdlrh ssevkrlccc
      181 esygkinpel vccnphhlsr lcelespppp ysrypmdflk ptadcpdavp ssaetggtny
      241 lapgglsdsq lllepgdrsh wcvvayweek trvgrlycvq epsldifydl pqgngfclgq
      301 lnsdnksqlv qkvrskigcg iqltrevdgv wvynrssypi fiksatldnp dsrtllvhkv
      361 fpgfsikafd yekayslqrp ndhefmqqpw tgftvqisfv kgwgqcytrq fisscpcwle
      421 vifnsr
//
LOCUS       NP_001161983             330 aa            linear   ROD 23-AUG-2025
DEFINITION  free fatty acid receptor 2 [Mus musculus].
ACCESSION   NP_001161983
VERSION     NP_001161983.1
DBSOURCE    REFSEQ: accession NM_001168511.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 330)
  AUTHORS   Jeong,H., Lee,B., Cho,S.Y., Lee,Y., Kim,J., Hur,S., Cho,K.,
            Kim,K.H., Kim,S.H. and Nam,K.T.
  TITLE     Microbiota-derived short-chain fatty acids determine stem cell
            characteristics of gastric chief cells
  JOURNAL   Dev Cell 60 (4), 599-612 (2025)
   PUBMED   39642880
REFERENCE   2  (residues 1 to 330)
  AUTHORS   Fachi,J.L., de Oliveira,S., Trsan,T., Penati,S., Gilfillan,S.,
            Cao,S., Ribeiro Castro,P., Fernandes,M.F., Hyrc,K.L., Liu,X.,
            Rodrigues,P.F., Bhattarai,B., Layden,B.T., Vinolo,M.A.R. and
            Colonna,M.
  TITLE     Fiber- and acetate-mediated modulation of MHC-II expression on
            intestinal epithelium protects from Clostridioides difficile
            infection
  JOURNAL   Cell Host Microbe 33 (2), 235-251 (2025)
   PUBMED   39826540
REFERENCE   3  (residues 1 to 330)
  AUTHORS   Shimizu,H., Miyamoto,J., Hisa,K., Ohue-Kitano,R., Takada,H.,
            Yamano,M., Nishida,A., Sasahara,D., Masujima,Y., Watanabe,K.,
            Nishikawa,S., Takahashi,S., Ikeda,T., Nakajima,Y., Yoshida,N.,
            Matsuzaki,C., Kageyama,T., Hayashi,I., Matsuki,A., Akashi,R.,
            Kitahama,S., Ueyama,M., Murakami,T., Inuki,S., Irie,J.,
            Satoh-Asahara,N., Toju,H., Mori,H., Nakaoka,S., Yamashita,T.,
            Toyoda,A., Yamamoto,K., Ohno,H., Katayama,T., Itoh,H. and Kimura,I.
  TITLE     Sucrose-preferring gut microbes prevent host obesity by producing
            exopolysaccharides
  JOURNAL   Nat Commun 16 (1), 1145 (2025)
   PUBMED   39880823
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 330)
  AUTHORS   Caetano-Silva,M.E., Rund,L., Vailati-Riboni,M., Matt,S.,
            Soto-Diaz,K., Beever,J., Allen,J.M., Woods,J.A., Steelman,A.J. and
            Johnson,R.W.
  TITLE     The emergence of inflammatory microglia during gut inflammation is
            not affected by FFAR2 expression in intestinal epithelial cells or
            peripheral myeloid cells
  JOURNAL   Brain Behav Immun 118, 423-436 (2024)
   PUBMED   38467381
  REMARK    GeneRIF: The emergence of inflammatory microglia during gut
            inflammation is not affected by FFAR2 expression in intestinal
            epithelial cells or peripheral myeloid cells.
REFERENCE   5  (residues 1 to 330)
  AUTHORS   Lee,A.R., Wilson,K.R., Clarke,M., Engel,S., Tscharke,D.C.,
            Gebhardt,T., Bedoui,S. and Bachem,A.
  TITLE     GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex
            virus type 1 infection
  JOURNAL   Front Immunol 15, 1332588 (2024)
   PUBMED   38524121
  REMARK    GeneRIF: GPR41 and GPR43 regulate CD8[+] T cell priming during
            herpes simplex virus type 1 infection.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 330)
  AUTHORS   Ge,H., Li,X., Weiszmann,J., Wang,P., Baribault,H., Chen,J.L.,
            Tian,H. and Li,Y.
  TITLE     Activation of G protein-coupled receptor 43 in adipocytes leads to
            inhibition of lipolysis and suppression of plasma free fatty acids
  JOURNAL   Endocrinology 149 (9), 4519-4526 (2008)
   PUBMED   18499755
  REMARK    GeneRIF: A potential role for GPR43 in regulating plasma lipid
            profiles and perhaps aspects of metabolic syndrome.
REFERENCE   7  (residues 1 to 330)
  AUTHORS   Hong,Y.H., Nishimura,Y., Hishikawa,D., Tsuzuki,H., Miyahara,H.,
            Gotoh,C., Choi,K.C., Feng,D.D., Chen,C., Lee,H.G., Katoh,K.,
            Roh,S.G. and Sasaki,S.
  TITLE     Acetate and propionate short chain fatty acids stimulate
            adipogenesis via GPCR43
  JOURNAL   Endocrinology 146 (12), 5092-5099 (2005)
   PUBMED   16123168
  REMARK    GeneRIF: Acetate and propionate short chain fatty acids may have
            important physiological roles in adipogenesis through GPCR43, but
            not through GPCR41.
REFERENCE   8  (residues 1 to 330)
  AUTHORS   Nilsson,N.E., Kotarsky,K., Owman,C. and Olde,B.
  TITLE     Identification of a free fatty acid receptor, FFA2R, expressed on
            leukocytes and activated by short-chain fatty acids
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1047-1052 (2003)
   PUBMED   12684041
REFERENCE   9  (residues 1 to 330)
  AUTHORS   Senga,T., Iwamoto,S., Yoshida,T., Yokota,T., Adachi,K., Azuma,E.,
            Hamaguchi,M. and Iwamoto,T.
  TITLE     LSSIG is a novel murine leukocyte-specific GPCR that is induced by
            the activation of STAT3
  JOURNAL   Blood 101 (3), 1185-1187 (2003)
   PUBMED   12393494
  REMARK    GeneRIF: induced by the activation of STAT3; might play pivotal
            role in differentiation and immune response of monocytes and
            granulocytes
REFERENCE   10 (residues 1 to 330)
  AUTHORS   Andrade,S.P., Machado,R.D., Teixeira,A.S., Belo,A.V., Tarso,A.M.
            and Beraldo,W.T.
  TITLE     Sponge-induced angiogenesis in mice and the pharmacological
            reactivity of the neovasculature quantitated by a fluorimetric
            method
  JOURNAL   Microvasc Res 54 (3), 253-261 (1997)
   PUBMED   9441896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX231878.1 and AK078861.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX231878.1, AA672048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.25 cM"
     Protein         1..330
                     /product="free fatty acid receptor 2"
                     /note="G protein-coupled receptor 43; leukocyte-specific
                     STAT-induced GPCR"
                     /calculated_mol_wt=36993
     Region          9..286
                     /region_name="7tmA_FFAR2_FFAR3"
                     /note="free fatty acid receptors 2, 3, and similar
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15170"
                     /db_xref="CDD:320298"
     Region          9..35
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320298"
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          44..69
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320298"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            order(65,68..69,82..87,89..90,93,138,140..144,176,
                     179..181,183..185,187..188,235,238..239,241..242,245,
                     251..252,254..256,259,262..263)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320298"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          82..112
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320298"
     Region          124..146
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320298"
     Site            127..147
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          176..205
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320298"
     Site            185..205
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          215..245
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320298"
     Site            220..240
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          252..277
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320298"
     Site            256..276
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     Region          306..330
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCK6.1)"
     CDS             1..330
                     /gene="Ffar2"
                     /gene_synonym="GPCR43; Gpr43"
                     /coded_by="NM_001168511.1:157..1149"
                     /db_xref="CCDS:CCDS21111.1"
                     /db_xref="GeneID:233079"
                     /db_xref="MGI:MGI:2441731"
ORIGIN      
        1 mtpdwhssli ltayiliflt glpanllalr afmgrvrqpq papvhillln ltladlllll
       61 llpfriveaa snfrwylpki vcaltgfgfy ssiycstwll agismerylg vafpvqykls
      121 rrplygviaa lvawimsfgh ctiviivqyl nsteqvgten qitcyenftq eqldvvlpvr
      181 lelclvlffv pmavtifcyw rfvwimltqp hvgaqrrrra vglavvtlln flvcfgpynm
      241 shlvgfylrq spswrveavv fsslnasldp llfyfsssvv rrafgkglll irnpassmlg
      301 rgaketvegt kmdrggsqae gvqssefvte
//
LOCUS       NP_001258115             183 aa            linear   PRI 23-AUG-2025
DEFINITION  ras-related protein Rap-2c isoform 1 precursor [Homo sapiens].
ACCESSION   NP_001258115
VERSION     NP_001258115.1
DBSOURCE    REFSEQ: accession NM_001271186.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 183)
  AUTHORS   Gambi,G., Mengus,G., Davidson,G., Demesmaeker,E., Cuomo,A.,
            Bonaldi,T., Katopodi,V., Malouf,G.G., Leucci,E. and Davidson,I.
  TITLE     The LncRNA LENOX Interacts with RAP2C to Regulate Metabolism and
            Promote Resistance to MAPK Inhibition in Melanoma
  JOURNAL   Cancer Res 82 (24), 4555-4570 (2022)
   PUBMED   36214632
  REMARK    GeneRIF: The LncRNA LENOX Interacts with RAP2C to Regulate
            Metabolism and Promote Resistance to MAPK Inhibition in Melanoma.
REFERENCE   2  (residues 1 to 183)
  AUTHORS   Cao,J., Jiang,M., Ren,H. and Xu,K.
  TITLE     MicroRNA-200c-3p suppresses intervertebral disc degeneration by
            targeting RAP2C/ERK signaling
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34676879
  REMARK    GeneRIF: MicroRNA200c3p suppresses intervertebral disc degeneration
            by targeting RAP2C/ERK signaling.
REFERENCE   3  (residues 1 to 183)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 183)
  AUTHORS   Zhu,X., Qiu,J., Zhang,T., Yang,Y., Guo,S., Li,T., Jiang,K.,
            Zahoor,A., Deng,G. and Qiu,C.
  TITLE     MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation
            of breast cancer cells via the MAPK signaling pathway by targeting
            Rap2c
  JOURNAL   J Cell Physiol 235 (3), 2389-2402 (2020)
   PUBMED   31541458
  REMARK    GeneRIF: MicroRNA-188-5p promotes apoptosis and inhibits cell
            proliferation of breast cancer cells via the MAPK signaling pathway
            by targeting Rap2c.
REFERENCE   5  (residues 1 to 183)
  AUTHORS   Chan,L.N., Hart,C., Guo,L., Nyberg,T., Davies,B.S., Fong,L.G.,
            Young,S.G., Agnew,B.J. and Tamanoi,F.
  TITLE     A novel approach to tag and identify geranylgeranylated proteins
  JOURNAL   Electrophoresis 30 (20), 3598-3606 (2009)
   PUBMED   19784953
REFERENCE   6  (residues 1 to 183)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 183)
  AUTHORS   Lilljebjorn,H., Heidenblad,M., Nilsson,B., Lassen,C., Horvat,A.,
            Heldrup,J., Behrendtz,M., Johansson,B., Andersson,A. and
            Fioretos,T.
  TITLE     Combined high-resolution array-based comparative genomic
            hybridization and expression profiling of ETV6/RUNX1-positive acute
            lymphoblastic leukemias reveal a high incidence of cryptic Xq
            duplications and identify several putative target genes within the
            commonly gained region
  JOURNAL   Leukemia 21 (10), 2137-2144 (2007)
   PUBMED   17690704
REFERENCE   8  (residues 1 to 183)
  AUTHORS   Guo,Z., Yuan,J., Tang,W., Chen,X., Gu,X., Luo,K., Wang,Y., Wan,B.
            and Yu,L.
  TITLE     Cloning and characterization of the human gene RAP2C, a novel
            member of Ras family, which activates transcriptional activities of
            SRE
  JOURNAL   Mol Biol Rep 34 (3), 137-144 (2007)
   PUBMED   17447155
  REMARK    GeneRIF: RAP2C is a novel member of the Ras family, belonging to
            the Rap branch of small GTPase proteins and may be involved in
            SRE-mediated gene transcription.
REFERENCE   9  (residues 1 to 183)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (residues 1 to 183)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
  REMARK    GeneRIF: This work demonstrates that Rap2C is a new member of the
            Rap2 subfamily of proteins, able to bind guanine nucleotides with
            peculiar properties, and differently expressed by various
            hematopoietic subsets
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX399437.2, DB252216.1,
            BC035382.1 and AY298955.1.
            
            Summary: The protein encoded by this gene is a member of the
            Ras-related protein subfamily of the Ras GTPase superfamily.
            Members of this family are small GTPases that act as molecular
            switches to regulate cellular proliferation, differentiation, and
            apoptosis. This protein has been reported to activate in vitro
            transcriptional activity of the serum response element. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370874.2/ ENSP00000359911.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     Protein         1..183
                     /product="ras-related protein Rap-2c isoform 1 precursor"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein Rap-2c; small GTPase RAP2C"
                     /calculated_mol_wt=20614
     mat_peptide     1..180
                     /product="Ras-related protein Rap-2c. /id=PRO_0000030221"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y3L5.1)"
                     /calculated_mol_wt=20418
     Region          3..165
                     /region_name="Rap2"
                     /note="Rap2 family GTPase consists of Rap2a, Rap2b, and
                     Rap2c; cd04176"
                     /db_xref="CDD:133376"
     Site            10..17
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:133376"
     Site            order(11..12,59..60)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133376"
     Site            order(13..18,28..31,116..117,119,146..147)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:133376"
     Site            order(17..18,32,34,40..41,54..55,57,59..60,148)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:133376"
     Site            order(25,31,33,36..41)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:133376"
     Region          32..40
                     /region_name="Effector region. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y3L5.1)"
     Site            33..40
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:133376"
     Site            35
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:133376"
     Site            57..60
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:133376"
     Site            order(59..65,68..73,76..77)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:133376"
     Site            116..119
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:133376"
     Site            146..148
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:133376"
     Site            180
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:Q8BU31; propagated from
                     UniProtKB/Swiss-Prot (Q9Y3L5.1)"
     CDS             1..183
                     /gene="RAP2C"
                     /coded_by="NM_001271186.2:824..1375"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS14632.1"
                     /db_xref="GeneID:57826"
                     /db_xref="HGNC:HGNC:21165"
                     /db_xref="MIM:301016"
ORIGIN      
        1 mreykvvvlg sggvgksalt vqfvtgtfie kydptiedfy rkeievdssp svleildtag
       61 teqfasmrdl yikngqgfil vyslvnqqsf qdikpmrdqi vrvkryekvp lilvgnkvdl
      121 eperevmsse gralaqewgc pfmetsaksk smvdelfaei vrqmnysslp ekqdqccttc
      181 vvq
//
LOCUS       NP_001177751             211 aa            linear   PRI 23-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 7 isoform 3 [Homo sapiens].
ACCESSION   NP_001177751
VERSION     NP_001177751.1
DBSOURCE    REFSEQ: accession NM_001190822.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 211)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   2  (residues 1 to 211)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (residues 1 to 211)
  AUTHORS   Dai,T., Qiu,S., Gao,X., Zhao,C., Ge,Z., Yang,Y., Tang,C. and
            Feng,S.
  TITLE     Circular RNA circWNK1 inhibits the progression of gastric cancer
            via regulating the miR-21-3p/SMAD7 axis
  JOURNAL   Cancer Sci 115 (3), 974-988 (2024)
   PUBMED   38287200
  REMARK    GeneRIF: Circular RNA circWNK1 inhibits the progression of gastric
            cancer via regulating the miR-21-3p/SMAD7 axis.
REFERENCE   4  (residues 1 to 211)
  AUTHORS   Liang,S., Zheng,R., Zuo,B., Li,J., Wang,Y., Han,Y., Dong,H.,
            Zhao,X., Zhang,Y., Wang,P., Meng,R., Jia,L., Yang,A. and Yan,B.
  TITLE     SMAD7 expression in CAR-T cells improves persistence and safety for
            solid tumors
  JOURNAL   Cell Mol Immunol 21 (3), 213-226 (2024)
   PUBMED   38177245
  REMARK    GeneRIF: SMAD7 expression in CAR-T cells improves persistence and
            safety for solid tumors.
REFERENCE   5  (residues 1 to 211)
  AUTHORS   Wu,Y., Xu,J., Tan,B., Yi,T., Liu,S., Yang,G., Li,K. and Zhao,X.
  TITLE     SMAD7 gene polymorphisms and their influence on patients with
            colorectal cancer
  JOURNAL   Cell Cycle 22 (21-22), 2424-2435 (2023)
   PUBMED   38146644
  REMARK    GeneRIF: SMAD7 gene polymorphisms and their influence on patients
            with colorectal cancer.
REFERENCE   6  (residues 1 to 211)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (residues 1 to 211)
  AUTHORS   Roijer,E., Moren,A., ten Dijke,P. and Stenman,G.
  TITLE     Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1
            by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 189-190 (1998)
   PUBMED   9730599
REFERENCE   8  (residues 1 to 211)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   9  (residues 1 to 211)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
REFERENCE   10 (residues 1 to 211)
  AUTHORS   Hayashi,H., Abdollah,S., Qiu,Y., Cai,J., Xu,Y.Y., Grinnell,B.W.,
            Richardson,M.A., Topper,J.N., Gimbrone,M.A. Jr., Wrana,J.L. and
            Falb,D.
  TITLE     The MAD-related protein Smad7 associates with the TGFbeta receptor
            and functions as an antagonist of TGFbeta signaling
  JOURNAL   Cell 89 (7), 1165-1173 (1997)
   PUBMED   9215638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301535.1, AF010193.1 and
            AC114684.10.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex
            translocates to the cytoplasm, where it interacts with TGF-beta
            receptor type-1 (TGFBR1), leading to the degradation of both the
            encoded protein and TGFBR1. Expression of this gene is induced by
            TGFBR1. Variations in this gene are a cause of susceptibility to
            colorectal cancer type 3 (CRCS3). Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301535.1, SRR1803617.26308.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     Protein         1..211
                     /product="mothers against decapentaplegic homolog 7
                     isoform 3"
                     /note="Mothers against decapentaplegic, drosophila,
                     homolog of, 7; MAD (mothers against decapentaplegic,
                     Drosophila) homolog 7; hSMAD7; MAD homolog 8; mothers
                     against DPP homolog 8; SMAD, mothers against DPP homolog
                     7"
                     /calculated_mol_wt=23770
     Region          39..209
                     /region_name="MH2_SMAD_7"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD7;
                     cd10500"
                     /db_xref="CDD:199825"
     Site            order(52,60..61,63,72..76,80,84,86..87,89,96,100..101,103,
                     174,198,205,207,209)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:199825"
     CDS             1..211
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /coded_by="NM_001190822.2:138..773"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS54186.1"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
ORIGIN      
        1 mdflkptadc pdavpssaet ggtnylapgg lsdsqlllep gdrshwcvva yweektrvgr
       61 lycvqepsld ifydlpqgng fclgqlnsdn ksqlvqkvrs kigcgiqltr evdgvwvynr
      121 ssypifiksa tldnpdsrtl lvhkvfpgfs ikafdyekay slqrpndhef mqqpwtgftv
      181 qisfvkgwgq cytrqfissc pcwlevifns r
//
LOCUS       NP_001429670             640 aa            linear   VRT 24-AUG-2025
DEFINITION  solute carrier family 2 member 13a isoform 1 [Danio rerio].
ACCESSION   NP_001429670 XP_073804492
VERSION     NP_001429670.1
DBSOURCE    REFSEQ: accession NM_001442741.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 640)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000004.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073804492.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01020811.1,
                                           SRR32588717.51515868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505391, SAMEA3505392
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     Protein         1..640
                     /product="solute carrier family 2 member 13a isoform 1"
                     /calculated_mol_wt=69619
     CDS             1..640
                     /gene="slc2a13a"
                     /coded_by="NM_001442741.1:128..2050"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:101882338"
                     /db_xref="ZFIN:ZDB-GENE-111027-21"
ORIGIN      
        1 msrkssddyn lrsmsnlmge rrkratddge rslikapssa svssagasaa apapadlera
       61 arkqfqqdvt pvfvyvlavf saiggflfgy dtgvvsgaml llkrdmnisa lwqellvsgt
      121 vaaaavsall ggclnglfgr rvciltasft faiggivlgs apnkeallvg rlilglglgi
      181 asmtvpvyia etspphlrgr lvtintlfit agqftasvid gafsymkheg wrymlglsvi
      241 pallqflgfl flpesprwli qkgltqkarr vlsqirgnqn ideeydtiks sieeeekdcg
      301 gegpviwrml tfpparrali vgcglqmfqq lsgintvmyy satilqmsgv rddklaiwlv
      361 tvtaftnflf tllgvwlver vgrrkltlgs ifgtvlslcv lsvgfllsaq hsppvtlhls
      421 dpttpnssca ahlscepcml dpgcgycyqe nstavfassc vpvnpaster aawgkcsnst
      481 hlpdsgiway nfcptsyswv vllglvlyla sfapgmgpmp wtvnseiypl warstgnacs
      541 agvnwtfnvl vsltflhmaq yltyygvffl ytslaftgff fiygclpetk grrleeiesl
      601 fenrlcscgi sdcdedrqve yirvkgsnyh lsdndasdve
//
LOCUS       NP_001429612             333 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC100002334 isoform 3 [Danio rerio].
ACCESSION   NP_001429612 XP_073808904
VERSION     NP_001429612.1
DBSOURCE    REFSEQ: accession NM_001442683.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Takeuchi,M., Yamaguchi,S., Sakakibara,Y., Hayashi,T., Matsuda,K.,
            Hara,Y., Tanegashima,C., Shimizu,T., Kuraku,S. and Hibi,M.
  TITLE     Gene expression profiling of granule cells and Purkinje cells in
            the zebrafish cerebellum
  JOURNAL   J Comp Neurol 525 (7), 1558-1585 (2017)
   PUBMED   27615194
  REMARK    Erratum:[J Comp Neurol. 2021 Aug 1;529(11):3127. doi:
            10.1002/cne.25135. PMID: 34050936]
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000001.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073808904.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588718.21172338.1,
                                           SRR32588721.709598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN08196787 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     Protein         1..333
                     /product="uncharacterized protein LOC100002334 isoform 3"
                     /calculated_mol_wt=36423
     CDS             1..333
                     /gene="sc:d189"
                     /gene_synonym="sc:d816; si:dkey-151m22.6; zgc:172122"
                     /coded_by="NM_001442683.1:408..1409"
                     /note="isoform 3 is encoded by transcript variant 5"
                     /db_xref="GeneID:100002334"
                     /db_xref="ZFIN:ZDB-GENE-080303-11"
ORIGIN      
        1 maglpfvlac nitmekgevl kqvlwldmtn ktilhyqpdk ydhvtrvdgv elsqqtaapq
       61 ahtsvitirk aapanegcyh clfdvypsgq qrgrtclslt amveqmdnkt vvsgkpvtfl
      121 cnyilsmrvr qvlwkktaeq gdtaivasyv kyskpvvtsp fkgrvslnps lgqtrlsihh
      181 aqtedegcyt ceyhtypdgi ksttaclsvy vlpnpeasyv tvsqgiiean csamsrpaae
      241 iswnveghnq tlgpavisfy qqgdgttmvv ssiqlqsell ddelvkcevh hqgletaiyv
      301 slnksknghv ilisascval vlilclcvcl kkc
//
LOCUS       NP_001429684             408 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC103910170 isoform 2 precursor [Danio
            rerio].
ACCESSION   NP_001429684 XP_073799842
VERSION     NP_001429684.1
DBSOURCE    REFSEQ: accession NM_001442755.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 408)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 408)
  AUTHORS   Rodriguez-Nunez,I., Wcisel,D.J., Litman,R.T., Litman,G.W. and
            Yoder,J.A.
  TITLE     The identification of additional zebrafish DICP genes reveals
            haplotype variation and linkage to MHC class I genes
  JOURNAL   Immunogenetics 68 (4), 295-312 (2016)
   PUBMED   26801775
REFERENCE   3  (residues 1 to 408)
  AUTHORS   Haire,R.N., Cannon,J.P., O'Driscoll,M.L., Ostrov,D.A.,
            Mueller,M.G., Turner,P.M., Litman,R.T., Litman,G.W. and Yoder,J.A.
  TITLE     Genomic and functional characterization of the diverse
            immunoglobulin domain-containing protein (DICP) family
  JOURNAL   Genomics 99 (5), 282-291 (2012)
   PUBMED   22386706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073799842.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588717.45167142.1,
                                           SRR32588722.27000227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..408
                     /product="uncharacterized protein LOC103910170 isoform 2
                     precursor"
                     /note="diverse immunoglobulin domain-containing protein
                     1.25"
                     /calculated_mol_wt=41519
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2485
     CDS             1..408
                     /gene="dicp1.19"
                     /gene_synonym="dicp1.16; dicp1.25"
                     /coded_by="NM_001442755.1:122..1348"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="GeneID:103910170"
                     /db_xref="ZFIN:ZDB-GENE-120306-13"
ORIGIN      
        1 madrsplfll lifwtlstgv fgagdthvfs rsgetvhlpc rntdqhcrts gttwtynryr
       61 htttaelvvl glkktnserl nlgsdcslfi srvttgdagl yicqqwrgnq kqgpdsvvfl
      121 hvvavsssss sssssssssd igpglsltls crlfsysgfs cdylfifedl hlcwvneagv
      181 dlntdsryqi sstgciisls ttlisededk qwrcgvyqrn qlktsdtftv hysaeaktkt
      241 tttttttttt ttttaaaavt pehntnpktv npraaspaea qtaaaaavtp dhntntttqa
      301 agsssavlsv llsaaalavf iasvlcliqr rrraahqrvs gesavkdenq vhyqtihmsi
      361 npaaraheqt edsvtysevt cagkkpeksa sdddgndlvt yaavsrra
//
LOCUS       NP_001429649             565 aa            linear   VRT 24-AUG-2025
DEFINITION  LOC100332354 isoform 1 precursor [Danio rerio].
ACCESSION   NP_001429649 XP_073800218
VERSION     NP_001429649.1
DBSOURCE    REFSEQ: accession NM_001442720.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 565)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073800218.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588728.18464557.1,
                                           SRR32588729.27976998.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505373,
                                           SAMEA3505376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..565
                     /product="LOC100332354 isoform 1 precursor"
                     /note="protein shisa-6 homolog; shisa family member 6"
                     /calculated_mol_wt=61639
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2282
     CDS             1..565
                     /gene="LOC100332354"
                     /gene_synonym="shisa6"
                     /coded_by="NM_001442720.1:297..1994"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:100332354"
                     /db_xref="ZFIN:ZDB-GENE-250813-1"
ORIGIN      
        1 mgirhlllll vyldplcvls asttkrskpp pkrppkvkev nstvaptvap rritqvqapi
       61 igdhdtclgy ydvsgqfdke facnntdhry ccgscflrfc cpvkakrldq rvctnyntpd
      121 wiktqppspa ptgdtydpal dqtnttvyit cgvialiiil gisakvaydk atrppqemnv
      181 hraladilrq qgpipisqye henigaidts pkentpvrts knhytpvhnk nnhghygken
      241 frsgqdmhnf issgfvtlgr ghlkaqhsvd dlgqlswqgd ldiplsynnh phdytshldl
      301 tgshtpkigh riehyekprm nniltsqtep ydlsfsrsfq nlthlppsye mamkadlgdk
      361 ddeyyirkhh laepprssnl qthmiklsve ppaprqkpkr vqramsqdhv lsparskphr
      421 dyglssysgg agglspyhgr ilseeqllsa drlhsqdpll spekmlslrr snlrekamsr
      481 alshtdmfmp ttpvmdrhyk mmkmhshpss snhenyntlt vnsaqagnkr qafanrrmht
      541 vdhlqyipgh hhhqyrtask tevtv
//
LOCUS       NP_001429679             640 aa            linear   VRT 24-AUG-2025
DEFINITION  STRA6-like isoform 3 [Danio rerio].
ACCESSION   NP_001429679 XP_073766051
VERSION     NP_001429679.1
DBSOURCE    REFSEQ: accession NM_001442750.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 640)
  AUTHORS   Madera,D., Alonso-Gomez,A., Delgado,M.J., Valenciano,A.I. and
            Alonso-Gomez,A.L.
  TITLE     Gene Characterization of Nocturnin Paralogues in Goldfish: Full
            Coding Sequences, Structure, Phylogeny and Tissue Expression
  JOURNAL   Int J Mol Sci 25 (1), 54 (2023)
   PUBMED   38203224
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 640)
  AUTHORS   Solanki,A.K., Kondkar,A.A., Fogerty,J., Su,Y., Kim,S.H.,
            Lipschutz,J.H., Nihalani,D., Perkins,B.D. and Lobo,G.P.
  TITLE     A Functional Binding Domain in the Rbpr2 Receptor Is Required for
            Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor
            Cell Survival in Zebrafish
  JOURNAL   Cells 9 (5), 1099 (2020)
   PUBMED   32365517
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 640)
  AUTHORS   Lobo,G.P., Pauer,G., Lipschutz,J.H. and Hagstrom,S.A.
  TITLE     The Retinol-Binding Protein Receptor 2 (Rbpr2) Is Required for
            Photoreceptor Survival and Visual Function in the Zebrafish
  JOURNAL   Adv Exp Med Biol 1074, 569-576 (2018)
   PUBMED   29721989
  REMARK    GeneRIF: Rbpr2 was found to be expressed exclusively in the liver,
            intestine, and pancreas, of staged zebrafish larvae. rbpr2 mutants
            had smaller eyes and shorter OS lengths and showed loss of PNA
            (cones) and rhodopsin (rods).  Rbpr2 is capable of vitamin
            A/retinol uptake and loss of this membrane receptor in zebrafish
            results in photoreceptor defects that adversely affect visual
            function.
REFERENCE   4  (residues 1 to 640)
  AUTHORS   Shi,Y., Obert,E., Rahman,B., Rohrer,B. and Lobo,G.P.
  TITLE     The Retinol Binding Protein Receptor 2 (Rbpr2) is required for
            Photoreceptor Outer Segment Morphogenesis and Visual Function in
            Zebrafish
  JOURNAL   Sci Rep 7 (1), 16207 (2017)
   PUBMED   29176573
  REMARK    GeneRIF: Rbpr2 loss in retina resulted in shorter photoreceptor
            outer segments, mislocalization and decrease in visual pigments,
            decreased expression of retinoic acid-responsive genes and
            photoreceptor cell loss and vision reduction.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 640)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000001.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073766051.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588735.1525217.1,
                                           SRR32588732.131973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA898400, SAMN18715719
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     Protein         1..640
                     /product="STRA6-like isoform 3"
                     /calculated_mol_wt=73155
     CDS             1..640
                     /gene="stra6l"
                     /gene_synonym="rbpr2; zgc:162946"
                     /coded_by="NM_001442750.1:249..2171"
                     /note="isoform 3 is encoded by transcript variant 5"
                     /db_xref="GeneID:100000104"
                     /db_xref="ZFIN:ZDB-GENE-070410-116"
ORIGIN      
        1 mfllslvqrr araqpfedrf pylkgrfgiv vpldfigsls nrwsygfafg aiapsviqlf
       61 sesyapfyvp nwakaivyli gaievgvayl pffaclstph rvlggilgll ytlmwlivrl
      121 ydtitcpagk ilgpyekpii lwpfylclff llgrfvyiiv kavrihlklq adeneedlhs
      181 hqfryvqtll rrppespepk swfrrkvydw dpyfkfpnrm igtsiisfig lymmtladyr
      241 lseytfdkld slkdsleqia lscnqtesvf tylipsinef sivarrswla ttifstltsv
      301 tytfhvlvcy rkhlkrlwrg qksflpekfh tpspavsvaa itrysgwqia ftlwgflivh
      361 fvqflfalmf vygvvlpiqk ghilswlsnv giilltifiv ialvvlqiil vqvfflqdkl
      421 spedkekpla innrkafhsf nyffffynvi mglsncvlrl vsscivgtwl vsridrtimq
      481 rgyesmdpgy stwigmifad hyhsnpvmvs fchlllgrtl ekggpaacsy atfsnntgnr
      541 taanfsadsq nsdqnkedel rkklvlhtgc svggrvrlrw lvlytllrnp slillrktkk
      601 lpqtdspdpl llaraitsqa qqadavcnkt aetepapldi
//
LOCUS       NP_001429669             588 aa            linear   VRT 24-AUG-2025
DEFINITION  NHERF family PDZ scaffold protein 2 isoform 2 [Danio rerio].
ACCESSION   NP_001429669 XP_073762338
VERSION     NP_001429669.1
DBSOURCE    REFSEQ: accession NM_001442740.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 588)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000001.1.
            
            On Aug 24, 2025 this sequence version replaced XP_073762338.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588714.38371639.1,
                                           SRR32588722.6251651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505385,
                                           SAMEA3505388 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     Protein         1..588
                     /product="NHERF family PDZ scaffold protein 2 isoform 2"
                     /note="solute carrier family 9, subfamily A (NHE3, cation
                     proton antiporter 3), member 3 regulator 2; SLC9A3
                     regulator 2"
                     /calculated_mol_wt=65953
     CDS             1..588
                     /gene="nherf2"
                     /gene_synonym="slc9a3r2"
                     /coded_by="NM_001442740.1:524..2290"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:100008366"
                     /db_xref="ZFIN:ZDB-GENE-171006-1"
ORIGIN      
        1 mantlereil erelrprlcy ltkgdrgygf hlhgernrga qyirkiepgs padlsglrsg
       61 drvvevngen vegethhqvv qrvlevehrt rllvvdrvtd eflkfhglpc teeraiemgs
      121 lssrssaass prgpatpppy srqsseaifi nkspsstggv mngsplyrah arltspvlls
      181 ppspktqaet epfnqlndkt sitsdtesft kltdetsimf eiesfnkhnt essitpesep
      241 epftklreet rvihehepft klteetrviq epepftklte etrvmhesep ftklreetrv
      301 iqepepftkl teetrvirdp kaftklnies sdtkhkaesv relstdlsrs qtstqessea
      361 vtkdlrprlc hmtlseqgyg fnlhckksra gqfirsvdpd spaehaglrp rdrlievngc
      421 sieglrhaev valvraggke tcllvvdpdt delfsrlgit ptsthlkart sppiinislk
      481 dppitngspr hqsyrssssr stlsetsael sfdtsnkltd sdhhssddar kpkhdgksme
      541 rpldpfwesg lhlsltaaea kqkarakrpn krappmdwsk kqqifsnf
//
LOCUS       NP_001429613             333 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC100002334 isoform 3 [Danio rerio].
ACCESSION   NP_001429613
VERSION     NP_001429613.1
DBSOURCE    REFSEQ: accession NM_001442684.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Takeuchi,M., Yamaguchi,S., Sakakibara,Y., Hayashi,T., Matsuda,K.,
            Hara,Y., Tanegashima,C., Shimizu,T., Kuraku,S. and Hibi,M.
  TITLE     Gene expression profiling of granule cells and Purkinje cells in
            the zebrafish cerebellum
  JOURNAL   J Comp Neurol 525 (7), 1558-1585 (2017)
   PUBMED   27615194
  REMARK    Erratum:[J Comp Neurol. 2021 Aug 1;529(11):3127. doi:
            10.1002/cne.25135. PMID: 34050936]
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Bayes,A., Collins,M.O., Reig-Viader,R., Gou,G., Goulding,D.,
            Izquierdo,A., Choudhary,J.S., Emes,R.D. and Grant,S.G.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588730.18855249.1,
                                           SRR32588729.2506568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476760, SAMN01765705
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="1"
                     /map="1"
     Protein         1..333
                     /product="uncharacterized protein LOC100002334 isoform 3"
                     /calculated_mol_wt=36423
     CDS             1..333
                     /gene="sc:d189"
                     /gene_synonym="sc:d816; si:dkey-151m22.6; zgc:172122"
                     /coded_by="NM_001442684.1:393..1394"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /db_xref="GeneID:100002334"
                     /db_xref="ZFIN:ZDB-GENE-080303-11"
ORIGIN      
        1 maglpfvlac nitmekgevl kqvlwldmtn ktilhyqpdk ydhvtrvdgv elsqqtaapq
       61 ahtsvitirk aapanegcyh clfdvypsgq qrgrtclslt amveqmdnkt vvsgkpvtfl
      121 cnyilsmrvr qvlwkktaeq gdtaivasyv kyskpvvtsp fkgrvslnps lgqtrlsihh
      181 aqtedegcyt ceyhtypdgi ksttaclsvy vlpnpeasyv tvsqgiiean csamsrpaae
      241 iswnveghnq tlgpavisfy qqgdgttmvv ssiqlqsell ddelvkcevh hqgletaiyv
      301 slnksknghv ilisascval vlilclcvcl kkc
//
LOCUS       NP_001429593             409 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC792833 [Danio rerio].
ACCESSION   NP_001429593
VERSION     NP_001429593.1
DBSOURCE    REFSEQ: accession NM_001442664.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Steinke,D., Salzburger,W., Braasch,I. and Meyer,A.
  TITLE     Many genes in fish have species-specific asymmetric rates of
            molecular evolution
  JOURNAL   BMC Genomics 7, 20 (2006)
   PUBMED   16466575
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588721.4853532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..409
                     /product="uncharacterized protein LOC792833"
                     /note="transmembrane protein 184b; transmembrane protein
                     184bb; transmembrane protein 184Bb, duplicate 2"
                     /calculated_mol_wt=45858
     CDS             1..409
                     /gene="tmem184bb.1"
                     /gene_synonym="si:ch211-229i14.3; si:dkey-217f16.5;
                     tmem184b; tmem184bb; tmem184bb.2"
                     /coded_by="NM_001442664.1:228..1457"
                     /db_xref="GeneID:792833"
                     /db_xref="ZFIN:ZDB-GENE-070705-124"
ORIGIN      
        1 maqlwrravs ltgngslvam apgpgvvtva peshnrsgpv ltpetpiflm tpaaqgisgi
       61 ftwtallltc qqiymhlryy ntpneqrhiv rilfivpiya fdswlsllff tneeyyvyfd
      121 tvrdcyeafv iynflslcye ylggesaima eirgkpiqss fvygscclwg rtysigflrf
      181 ckqatlqfcv vkplmaiitv ilqafgkyrd gdfnaaggyl yvmiiynvsv slslfalflf
      241 ysataellep yspmlkflmv ksviflsfwq gmllailekc gafarisspd vsvgegtvaa
      301 gyqnfiicce mffaalalrh aftfkvymdk rldlqdcvpv ygqfgrsapm sissslketm
      361 npgdilqdai hnfspayqqy tqqsraepis rsdscsnekt lllssddef
//
LOCUS       NP_001352876             336 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC100126137 [Danio rerio].
ACCESSION   NP_001352876 NP_001103333
VERSION     NP_001352876.2
DBSOURCE    REFSEQ: accession NM_001365947.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 336)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 336)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            On Jul 28, 2025 this sequence version replaced NP_001352876.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26395063.21483.1,
                                           SRR32588733.2827603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..336
                     /product="uncharacterized protein LOC100126137"
                     /calculated_mol_wt=39498
     CDS             1..336
                     /gene="zgc:174288"
                     /coded_by="NM_001365947.3:262..1272"
                     /db_xref="GeneID:100126137"
                     /db_xref="ZFIN:ZDB-GENE-071004-120"
ORIGIN      
        1 msdpepcrit dedteeqtdl teeseesedd ellktgktph lqtedalmqr dkkcltcsqc
       61 gktlgnkrsl sqhmmihtge kpftctqcgm tfrqssslkv hmmihtgenp fscthcgksf
      121 rlssslkehm mihtgerkhr cdqcsraffr astlkrhlrt htkekpyscs ecgkrfttqs
      181 nlkqhqkiht gvkeymcfdc ektfikpehl klhqrihtge kpykcshcdk rfahleyqkl
      241 herthtgekp ykcshcdkrf kcladrnrhh kihtgekpyk cshcdkrfkc layrnrhhki
      301 htrekpyscd qclerfthsv qlkkhlkvht gekqht
//
LOCUS       NP_001429572            3615 aa            linear   VRT 24-AUG-2025
DEFINITION  sushi, von Willebrand factor type A, EGF and pentraxin
            domain-containing protein 1 precursor [Danio rerio].
ACCESSION   NP_001429572 XP_695742
VERSION     NP_001429572.1
DBSOURCE    REFSEQ: accession NM_001442643.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 3615)
  AUTHORS   Hussmann,M., Schulte,D., Weischer,S., Carlantoni,C., Nakajima,H.,
            Mochizuki,N., Stainier,D.Y.R., Zobel,T., Koch,M. and
            Schulte-Merker,S.
  TITLE     Svep1 is a binding ligand of Tie1 and affects specific aspects of
            facial lymphatic development in a Vegfc-independent manner
  JOURNAL   Elife 12, e82969 (2023)
   PUBMED   37097004
  REMARK    GeneRIF: Svep1 is a binding ligand of Tie1 and affects specific
            aspects of facial lymphatic development in a Vegfc-independent
            manner.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 3615)
  AUTHORS   Peng,D., Ando,K., Hussmann,M., Gloger,M., Skoczylas,R.,
            Mochizuki,N., Betsholtz,C., Fukuhara,S., Schulte-Merker,S.,
            Lawson,N.D. and Koltowska,K.
  TITLE     Proper migration of lymphatic endothelial cells requires survival
            and guidance cues from arterial mural cells
  JOURNAL   Elife 11, e74094 (2022)
   PUBMED   35316177
  REMARK    Erratum:[Elife. 2023 Jun 12;12:e90048. doi: 10.7554/eLife.90048.
            PMID: 37307048]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 3615)
  AUTHORS   Coxam,B., Collins,R.T., Hussmann,M., Huisman,Y., Meier,K., Jung,S.,
            Bartels-Klein,E., Szymborska,A., Finotto,L., Helker,C.S.M.,
            Stainier,D.Y.R., Schulte-Merker,S. and Gerhardt,H.
  TITLE     Svep1 stabilises developmental vascular anastomosis in reduced flow
            conditions
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35312765
REFERENCE   4  (residues 1 to 3615)
  AUTHORS   Szenker-Ravi,E., Ott,T., Khatoo,M., Moreau de Bellaing,A.,
            Goh,W.X., Chong,Y.L., Beckers,A., Kannesan,D., Louvel,G.,
            Anujan,P., Ravi,V., Bonnard,C., Moutton,S., Schoen,P., Fradin,M.,
            Colin,E., Megarbane,A., Daou,L., Chehab,G., Di Filippo,S.,
            Rooryck,C., Deleuze,J.F., Boland,A., Arribard,N., Eker,R.,
            Tohari,S., Ng,A.Y., Rio,M., Lim,C.T., Eisenhaber,B., Eisenhaber,F.,
            Venkatesh,B., Amiel,J., Crollius,H.R., Gordon,C.T., Gossler,A.,
            Roy,S., Attie-Bitach,T., Blum,M., Bouvagnet,P. and Reversade,B.
  TITLE     Discovery of a genetic module essential for assigning left-right
            asymmetry in humans and ancestral vertebrates
  JOURNAL   Nat Genet 54 (1), 62-72 (2022)
   PUBMED   34903892
  REMARK    Erratum:[Nat Genet. 2022 Jun;54(6):906. doi:
            10.1038/s41588-022-01053-8. PMID: 35304595]
REFERENCE   5  (residues 1 to 3615)
  AUTHORS   Wang,G., Muhl,L., Padberg,Y., Dupont,L., Peterson-Maduro,J.,
            Stehling,M., le Noble,F., Colige,A., Betsholtz,C.,
            Schulte-Merker,S. and van Impel,A.
  TITLE     Specific fibroblast subpopulations and neuronal structures provide
            local sources of Vegfc-processing components during zebrafish
            lymphangiogenesis
  JOURNAL   Nat Commun 11 (1), 2724 (2020)
   PUBMED   32483144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 3615)
  AUTHORS   Samuelov,L., Li,Q., Bochner,R., Najor,N.A., Albrecht,L.,
            Malchin,N., Goldsmith,T., Grafi-Cohen,M., Vodo,D., Fainberg,G.,
            Meilik,B., Goldberg,I., Warshauer,E., Rogers,T., Edie,S.,
            Ishida-Yamamoto,A., Burzenski,L., Erez,N., Murray,S.A.,
            Irvine,A.D., Shultz,L., Green,K.J., Uitto,J., Sprecher,E. and
            Sarig,O.
  TITLE     SVEP1 plays a crucial role in epidermal differentiation
  JOURNAL   Exp Dermatol 26 (5), 423-430 (2017)
   PUBMED   27892606
  REMARK    GeneRIF: knockdown caused rugged epidermis with perturbed
            microridge formation in the centre of the keratinocytes of morphant
            larvae
REFERENCE   7  (residues 1 to 3615)
  AUTHORS   Karpanen,T., Padberg,Y., van de Pavert,S.A., Dierkes,C.,
            Morooka,N., Peterson-Maduro,J., van de Hoek,G., Adrian,M.,
            Mochizuki,N., Sekiguchi,K., Kiefer,F., Schulte,D. and
            Schulte-Merker,S.
  TITLE     An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic
            Vessel Formation
  JOURNAL   Circ Res 120 (8), 1263-1275 (2017)
   PUBMED   28179432
  REMARK    GeneRIF: Polydom/Svep1 is an essential extracellular factors for
            lymphangiogenesis.
REFERENCE   8  (residues 1 to 3615)
  AUTHORS   Morooka,N., Futaki,S., Sato-Nishiuchi,R., Nishino,M., Totani,Y.,
            Shimono,C., Nakano,I., Nakajima,H., Mochizuki,N. and Sekiguchi,K.
  TITLE     Polydom Is an Extracellular Matrix Protein Involved in Lymphatic
            Vessel Remodeling
  JOURNAL   Circ Res 120 (8), 1276-1288 (2017)
   PUBMED   28179430
REFERENCE   9  (residues 1 to 3615)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 3615)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000007.1.
            
            On Aug 18, 2025 this sequence version replaced XP_695742.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01024018.1, SRR32588727.772996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705, SAMN06350654
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3615
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     Protein         1..3615
                     /product="sushi, von Willebrand factor type A, EGF and
                     pentraxin domain-containing protein 1 precursor"
                     /note="polydom; sushi, von Willebrand factor type A, EGF
                     and pentraxin domain-containing protein 1"
                     /calculated_mol_wt=390543
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
                     /calculated_mol_wt=2872
     mat_peptide     26..3615
                     /product="Sushi, von Willebrand factor type A, EGF and
                     pentraxin domain-containing protein 1.
                     /evidence=ECO:0000255. /id=PRO_5039851615"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A1D5NSM8.1)"
                     /calculated_mol_wt=390543
     Site            47
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            181
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            365
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            445
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            543
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            579
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            629
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            678
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            707
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            742
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            921
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            933
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     Site            1415
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (A0A1D5NSM8.1)"
     CDS             1..3615
                     /gene="svep1"
                     /coded_by="NM_001442643.1:457..11304"
                     /db_xref="GeneID:567357"
                     /db_xref="ZFIN:ZDB-GENE-110726-1"
ORIGIN      
        1 mmvtlrlalt lrltvlllyw sgctcwpsha qqfslqslrq tsqarqnlse saeskverlg
       61 qvfrknvrll rerggcldlv flvdesssvg asnfkselrf vrkmlsdfpv apeatrvalv
      121 tfsskshvvt radyvsapka hqhkcslfsk eipsityrgg gtytrgafqr aaqilrqsre
      181 natkviflit dgysnggdpr pvaaalrerg veiftlgiwq gnirelhema sqpkdqhcff
      241 vhnfaefeal arralhedlp sgnyiqedla qcsslcdggk dccdlmasck cgthtgqydc
      301 vcekgyygkg lqhectacps atykpeavag gastclpcpd phhtsrpgst disdcvcleg
      361 yrphnntcqa vvcpvlsppe ngffiqnvcn nqfnsacgvr clpgfdlqgd girlcqpdgt
      421 wsgvqpscri rscpdlspph hgmlncsers apyrleclvr ceqgyrlqgr aritclansq
      481 wsgpqprcve vrcppivtlk hihlmpstcg enevrtgavc qlscpygysl igdskvkclp
      541 tgnwsdnlhk atctdveppw iqcpgdvite tdehqrsanv slsapmlrdn sgdevmvqvt
      601 pvlnpmqtfp igtefityta tdrtgnkanc sftvtvvdte pplidrcrsp ptvkatgrkt
      661 avyweepqfs dnsgaqlnis sthssgdifp vgetsvyyta tdpsgnnrtc eliitvrgst
      721 cekpfvpvng dfscaktkeg mnctlicrqg yslaqnavhs yfcanngiwe pprspdrpdc
      781 slnrianngf kpfemlfkas rcddlnlvrs fsgefsnvlk ntvpnicggd dvscklemtl
      841 paqcleynyd ypngfaigpg gwgsnwgsqn gedyayfdsg fapehqlqkd assqhgshmr
      901 tkrhrkitgp treqkiqihf nitasiplpl srndsaeivn qkrllraleq ltnrlkrtla
      961 kqpfstfhvs semivadpks leskkatlyc rpgsvlkgrv cvlcpvgtyf sleyaecesc
     1021 wrgsyqneeg qmeckscpdg sstpylhsrs qaeckaqcqp gsssltglet cescplgeyq
     1081 pgfgsqdcls cpsttttvnr galdvnecgv pcsaghfsrt glvpcypcpr dyyqpeegrs
     1141 yclscpfygt ttitgaraiq qcssfgssfl pkeesattap evivrkdyqa ssqmfhecll
     1201 npcqnqgtce evgvgyvctc lpgftgakce sdidecdsap cqngglcrdg mgdfqcqcqp
     1261 gfvgllceae vnecssspcl negicvdevn yfscscpdgf tgprcemein ecasspcqne
     1321 gvckdleggy fctcaqgftg dncevdvnec ysapclnggt cvdaindfrc ecvngyrgrl
     1381 cqvdvddcel nlclngatcv dgvatftcrc ppgfngtrce tempysfdle fevsgihgyv
     1441 mmdghmpslt qitctfwmrs sdtvnygtpv syavegsdna fllidyngwv lyvngkerit
     1501 dcpavndglw hhigvtwrsk dgdwrvyidg spsdggkgls igttipggga lvlgqdqdqr
     1561 gdgfnpvesf vgtlsqlniw nyvltpqqir slasscphdl qkgnvfawpd flggvtgrvk
     1621 ttsksifcad cplvetsvph llssskavsp gskvqfscsp gfylvgepvq lclnrgqwsh
     1681 aepicervec gpppdlehgq yhgedfyags svlyqckpgf yllgeskmqc tnngkwignp
     1741 pacldvdecs lgsecdehas cqntdgshic tciapysgdg rnctepvkck dpgvpefgqr
     1801 egtnfimgse vvfsckegye ligssqltct eegfwkqdvp yckalscphp tlpkygilkg
     1861 anftygskvt fscekgyvpl epiesqcqsd lkwsrephic qpitcgeppv vdyaeytlng
     1921 kiyrstlsyt ciegyrlqga melqcessge wtspppmcar vdcgkppplk davikgdnft
     1981 lgskiyyick dgytllgaet qeclpsgnwt rnssqcvprs cgpppqvdha lpdtghqlfg
     2041 diaiyfcddg ytagnntklf cnaqgvwapp dgfgiphcia nfcqrppdlp haildsinkp
     2101 kyasntevsy kceegfvlnt tgtlkcligg ewtpspsdig cmpvrcskpe siekgyvsgn
     2161 nygfgaviay scdkgyfirg ekkrickasg ewggvlptcq piscpspprl angfiqgqir
     2221 knsyvynskv tyacndgyrl tgkpertcma nkqwsnsnsl vcvlltcptp pdiknglyhg
     2281 stfevgskve fvcnegyeli gdtvwtclkf gnwdksiipr cspvqcpepp leenhlvlrg
     2341 ldsdsgtvel sceegyvlhg artlrctpsq ewndsfpvck qvfcgpppev afgdpsdtqs
     2401 yfgsvvtysc mdgftlrkeg svhcqangnw skpypqcipv ecphpedipn givdvqglmy
     2461 lstavyscka gydilgnstv lcgqsgqwig gipvchpvkc aapkeipngs vrysklqfsq
     2521 sityfcqrgy riqgpetltc lengqwdqea ptcvpiycsp pkpidngfve grdrkfgvti
     2581 fyscfpgfll vgnnhltced hgwsssepkc vladcglpph idfgdyskvq elsaeydmvt
     2641 sqqlpvdnsf lhgslvkyhc hsgyeingai mlmcredgtw ngtapmctpa qceappspen
     2701 gsvmvtdsal gslaeyscae gyelngqtir qcisgqqwsd daprclpisc gnpggiange
     2761 vigksfhfke lihyechsgf vlegvetrtc qvdgkwdnka plckevscgr pvvskdvlvr
     2821 gddhtfgkrl lfscnlgfil lgaptivcla ngswnevppk clpancgqpp siengrvtgt
     2881 dygyngmvry acdigyvltg nptlicradg lwddppprcd iitcdppedi shgylngssf
     2941 nfddiveyic fpgyevvgsp ilrcaaegvw lgqvpecrpc vcsppvfkyg silgrdhtcg
     3001 asiwfrcddg ykilgsseai cdkggvwspg vpictrgrcs ipppavpnav iqgstaytid
     3061 tvtyrcrpgy hlkgfphisc grlgrwgepn lscepiscgv pplisnaetv gavltygska
     3121 qyrckegfel atktdsitcq sdgtwskhgv rcrpspctlp tnlthvvitg kqltpvggtv
     3181 ivscrpgyyl egpglsectv sgkwspplas clpvicekpl pilnglvegi synygdvvnf
     3241 tcqqgfllqg hsvrtcqgdk twsgtqpvca avscgpppvv pnavasssgq tyksivsytc
     3301 rqgtslvdsq nltcqangsw slptpicevp ggcekitdll ngkvqehnls sgralefhcn
     3361 kgytlqgesl vmcvgngsws spfpvclpkp cpplphgwtv gsanatqtvf svgqsvqvsc
     3421 pkgqrvksnq gkgiatltcr sdqtwtpisa vcervscgpp lyvsngvvrg avfqfgdmvl
     3481 yscyagftme gssrsvcldn gtwtqpptck avcwrhcqng gvcqrpntcs cpegwmgrfc
     3541 eepicilpcl nggrcvapyq cecpagwtgt rchnavcsmp clnggrcirp nrchcspgwg
     3601 gydcsrkrks ayfhf
//
LOCUS       NP_001429595             270 aa            linear   VRT 24-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC12-B [Danio rerio].
ACCESSION   NP_001429595 XP_021327289
VERSION     NP_001429595.1
DBSOURCE    REFSEQ: accession NM_001442666.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 270)
  AUTHORS   Du,Z., Chen,X., Li,X., He,K., Ji,S., Shi,W. and Hao,A.
  TITLE     Protein palmitoylation activate zygotic gene expression during the
            maternal-to-zygotic transition
  JOURNAL   Biochem Biophys Res Commun 475 (2), 194-201 (2016)
   PUBMED   27235108
REFERENCE   2  (residues 1 to 270)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 270)
  AUTHORS   Wang,C., Chen,X., Shi,W., Wang,F., Du,Z., Li,X., Yao,Y., Liu,T.,
            Shao,T., Li,G. and Hao,A.
  TITLE     2-Bromopalmitate impairs neural stem/progenitor cell proliferation,
            promotes cell apoptosis and induces malformation in zebrafish
            embryonic brain
  JOURNAL   Neurotoxicol Teratol 50, 53-63 (2015)
   PUBMED   26056731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000005.1.
            
            On Aug 20, 2025 this sequence version replaced XP_021327289.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GDQH01035374.1,
                                           SRR26395039.1262017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505373, SAMEA3505377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="5"
                     /map="5"
     Protein         1..270
                     /product="palmitoyltransferase ZDHHC12-B"
                     /EC_number="2.3.1.225"
                     /note="zdhhc12; zinc finger DHHC-type containing 12b; zinc
                     finger DHHC-type palmitoyltransferase 12b; zinc finger
                     DHHC domain-containing protein 12-B"
                     /calculated_mol_wt=31109
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E7F021.1)"
     Site            43..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E7F021.1)"
     Site            146..166
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E7F021.1)"
     Site            183..203
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (E7F021.1)"
     CDS             1..270
                     /gene="zdhhc12b"
                     /gene_synonym="si:dkey-202g15.2"
                     /coded_by="NM_001442666.1:324..1136"
                     /db_xref="GeneID:569129"
                     /db_xref="ZFIN:ZDB-GENE-070705-356"
ORIGIN      
        1 mfknvfgsgf lvrtahvilt wvitlilflh dtdlrrqeet geltlpvlfv llvlvsvlly
       61 favslmdpgf vltddcdlqf tlgiaeetqd mipqttksir lrrcghclvq qpmrskhcqt
      121 cqhcvrrydh hcpwiencvg ernhrwfvly lavqfvvllw glymawsgfs hastwqqwlr
      181 tngvllgaaa vvailaltvl lllgshlylv slntttwefm srhrisylkh cgadenpfdk
      241 gilrnlwgff cawepvvweh vyfkqgndpi
//
LOCUS       NP_001429682             606 aa            linear   VRT 24-AUG-2025
DEFINITION  BICD family-like cargo adapter 1 [Danio rerio].
ACCESSION   NP_001429682 XP_073766146
VERSION     NP_001429682.1
DBSOURCE    REFSEQ: accession NM_001442753.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 606)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 606)
  AUTHORS   Diotel,N., Rodriguez Viales,R., Armant,O., Marz,M., Ferg,M.,
            Rastegar,S. and Strahle,U.
  TITLE     Comprehensive expression map of transcription regulators in the
            adult zebrafish telencephalon reveals distinct neurogenic niches
  JOURNAL   J Comp Neurol 523 (8), 1202-1221 (2015)
   PUBMED   25556858
REFERENCE   3  (residues 1 to 606)
  AUTHORS   Schlager,M.A., Kapitein,L.C., Grigoriev,I., Burzynski,G.M.,
            Wulf,P.S., Keijzer,N., de Graaff,E., Fukuda,M., Shepherd,I.T.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     Pericentrosomal targeting of Rab6 secretory vesicles by
            Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
  JOURNAL   EMBO J 29 (10), 1637-1651 (2010)
   PUBMED   20360680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000008.1.
            
            On Aug 22, 2025 this sequence version replaced XP_073766146.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588729.27803.1,
                                           SRR32588719.5363178.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505374 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     Protein         1..606
                     /product="BICD family-like cargo adapter 1"
                     /note="bicaudal-D-related protein 1; coiled-coil domain
                     containing 64; BICD-related protein 1; coiled-coil
                     domain-containing protein 64A"
                     /calculated_mol_wt=69938
     CDS             1..606
                     /gene="bicdl1"
                     /gene_synonym="BICDR-1; ccdc64; si:ch73-370c12.2;
                     zBICDR-1"
                     /coded_by="NM_001442753.1:310..2130"
                     /db_xref="GeneID:100537719"
                     /db_xref="ZFIN:ZDB-GENE-091204-439"
ORIGIN      
        1 msascldlis appqpdsdrm dralnpgrqn spdtageltl lhtapgglgm aleeelamlt
       61 gdredelqes apetpvsgqd sdllslfrqk ekdlvlaakl gkallernqd ltkqydkmtk
      121 dlndrlelle qekhelrrrl esregewegr vaeletdvqh lqgelerhql qlrdadreks
      181 raiselseqn hrlleqlsra aevekqlstq vhslrddfke ksissnqhmt rletlqaeir
      241 mlserkqdle rrvcavleen qqlqntveel rertlelekh chhkdlqlrq cqlelqevrv
      301 shrqlssrld elteehslqa fspsthnllc eieqsmeqee leqereqlrl qlweaycqvr
      361 sicsqlrgnd itdsalstds smdessetls akdvptgslh ssllelrrlt qnlldgnest
      421 gsrrsdeevl eeqvrklgee lrdlrelyeq eqekthssqe ealqlhnqva llsvevsssr
      481 eenerlramt evhepneqlq sairdrdeai akkkavemel akckidimsl nsqlldaiqq
      541 klnlsqqlea wqddmhrvid qqlmdkhqee wndppfsfsr rgaaasrptq rladrdkplf
      601 sffkkn
//
LOCUS       NP_001429592             409 aa            linear   VRT 24-AUG-2025
DEFINITION  uncharacterized protein LOC792833 [Danio rerio].
ACCESSION   NP_001429592 XP_009297322
VERSION     NP_001429592.1
DBSOURCE    REFSEQ: accession NM_001442663.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Steinke,D., Salzburger,W., Braasch,I. and Meyer,A.
  TITLE     Many genes in fish have species-specific asymmetric rates of
            molecular evolution
  JOURNAL   BMC Genomics 7, 20 (2006)
   PUBMED   16466575
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000003.1.
            
            On Aug 20, 2025 this sequence version replaced XP_009297322.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR32588728.12930286.1,
                                           SRR32588718.30062766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505370,
                                           SAMEA3505371 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Danio rerio"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     Protein         1..409
                     /product="uncharacterized protein LOC792833"
                     /note="transmembrane protein 184b; transmembrane protein
                     184bb; transmembrane protein 184Bb, duplicate 2"
                     /calculated_mol_wt=45858
     CDS             1..409
                     /gene="tmem184bb.1"
                     /gene_synonym="si:ch211-229i14.3; si:dkey-217f16.5;
                     tmem184b; tmem184bb; tmem184bb.2"
                     /coded_by="NM_001442663.1:174..1403"
                     /db_xref="GeneID:792833"
                     /db_xref="ZFIN:ZDB-GENE-070705-124"
ORIGIN      
        1 maqlwrravs ltgngslvam apgpgvvtva peshnrsgpv ltpetpiflm tpaaqgisgi
       61 ftwtallltc qqiymhlryy ntpneqrhiv rilfivpiya fdswlsllff tneeyyvyfd
      121 tvrdcyeafv iynflslcye ylggesaima eirgkpiqss fvygscclwg rtysigflrf
      181 ckqatlqfcv vkplmaiitv ilqafgkyrd gdfnaaggyl yvmiiynvsv slslfalflf
      241 ysataellep yspmlkflmv ksviflsfwq gmllailekc gafarisspd vsvgegtvaa
      301 gyqnfiicce mffaalalrh aftfkvymdk rldlqdcvpv ygqfgrsapm sissslketm
      361 npgdilqdai hnfspayqqy tqqsraepis rsdscsnekt lllssddef
//
