#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C6U8-PRO_0000338255	reactome:R-HSA-68507	intact:EBI-27125441	intact:EBI-850302|intenz:2.7.7.7|wwpdb:5EXR|rhea:"RHEA:22508"	psi-mi:p0c6u8-pro_0000338255(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:pol-prim_human(display_short)|psi-mi:R-HSA-68507(display_long)|intact:DPOLA-DPOA2-PRI1-PRI2 complex(complex synonym)|intact:"POLA1:POLA2:PRIM1:PRIM2"(complex systematic name)|intact:"DNA polymerase alpha:primase complex"(complex recommended name)|intact:"Alpha DNA polymerase:primase complex"(complex synonym)|intact:heterotetrameric polymerase alpha holoenzyme(complex synonym)|intact:pol-prim(complex synonym)|intact:primosome(complex synonym)|intact:Pol alpha-primase complex(complex synonym)|intact:polymerase alpha-primase complex(complex synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kilkenny et al. (2021)	pubmed:34719824|imex:IM-29359	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27125426|wwpdb:7OPL|emdb:EMD-13020|emdb:EMD-13021|imex:IM-29359-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	intact:EBI-15810860(chain-parent)	intact:EBI-850066(exp-evidence)|pubmed:12806117(see-also)|wwpdb:4Y97(subset)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|evidence ontology:"ECO:0000353"|complex portal:CPX-2087(complex-primary)|pubmed:26975377(see-also)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0003697"(single-stranded DNA binding)	-	chain-seq-start:1|chain-seq-end:180	curated-complex:"Initiates DNA replication by synthesizing short RNA primers on the leading and lagging strand templates in a minimum of five steps: template binding, NTP binding, dinucleotide formation, extension to a functional RNA primer, and primer transfer to the POLA catalytic site for elongation into hybrid primers of about 35 nucleotides."|complex-assembly:Heterotetramer	figure legend:Supp. Table 1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/18	rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009	-	-	false	sufficient binding region:13-127	sufficient binding region:149-598|strep tag:n-n|strep tag:n-n|sufficient binding region:334-1462|his tag:n-n	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P0C6U8-PRO_0000338255	reactome:R-HSA-68507	intact:EBI-27125441	intact:EBI-850302|intenz:2.7.7.7|wwpdb:5EXR|rhea:"RHEA:22508"	psi-mi:p0c6u8-pro_0000338255(display_long)|uniprotkb:ORF1a polyprotein(gene name synonym)|uniprotkb:1a(orf name)	psi-mi:pol-prim_human(display_short)|psi-mi:R-HSA-68507(display_long)|intact:DPOLA-DPOA2-PRI1-PRI2 complex(complex synonym)|intact:"POLA1:POLA2:PRIM1:PRIM2"(complex systematic name)|intact:"DNA polymerase alpha:primase complex"(complex recommended name)|intact:"Alpha DNA polymerase:primase complex"(complex synonym)|intact:heterotetrameric polymerase alpha holoenzyme(complex synonym)|intact:pol-prim(complex synonym)|intact:primosome(complex synonym)|intact:Pol alpha-primase complex(complex synonym)|intact:polymerase alpha-primase complex(complex synonym)	psi-mi:"MI:0096"(pull down)	Kilkenny et al. (2021)	pubmed:34719824|imex:IM-29359	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27125478|imex:IM-29359-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	intact:EBI-15810860(chain-parent)	intact:EBI-850066(exp-evidence)|pubmed:12806117(see-also)|wwpdb:4Y97(subset)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|evidence ontology:"ECO:0000353"|complex portal:CPX-2087(complex-primary)|pubmed:26975377(see-also)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0003697"(single-stranded DNA binding)	-	chain-seq-start:1|chain-seq-end:180	curated-complex:"Initiates DNA replication by synthesizing short RNA primers on the leading and lagging strand templates in a minimum of five steps: template binding, NTP binding, dinucleotide formation, extension to a functional RNA primer, and primer transfer to the POLA catalytic site for elongation into hybrid primers of about 35 nucleotides."|complex-assembly:Heterotetramer	figure legend:Figure 1,2|comment:Both full-length and truncated forms of purified primosome were pulled-down.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/18	rogid:qbwEpGmE3J035KnL6QbEZ/HRJAw694009	-	-	false	mutation decreasing interaction strength:27-27|maltose binding protein tag:n-n|his tag:?-?|sufficient binding region:13-127|mutation disrupting interaction strength:28-28|mutation disrupting interaction strength:111-111	sufficient binding region:149-598|strep tag:n-n|strep tag:n-n|sufficient binding region:334-1462|his tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
intact:EBI-27125556	reactome:R-HSA-68507	-	intact:EBI-850302|intenz:2.7.7.7|wwpdb:5EXR|rhea:"RHEA:22508"	psi-mi:dna45(display_short)|psi-mi:EBI-27125556(display_long)	psi-mi:pol-prim_human(display_short)|psi-mi:R-HSA-68507(display_long)|intact:DPOLA-DPOA2-PRI1-PRI2 complex(complex synonym)|intact:"POLA1:POLA2:PRIM1:PRIM2"(complex systematic name)|intact:"DNA polymerase alpha:primase complex"(complex recommended name)|intact:"Alpha DNA polymerase:primase complex"(complex synonym)|intact:heterotetrameric polymerase alpha holoenzyme(complex synonym)|intact:pol-prim(complex synonym)|intact:primosome(complex synonym)|intact:Pol alpha-primase complex(complex synonym)|intact:polymerase alpha-primase complex(complex synonym)	psi-mi:"MI:0699"(rna directed dna polymerase assay)	Kilkenny et al. (2021)	pubmed:34719824|imex:IM-29359	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27125535|imex:IM-29359-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0680"(single stranded deoxyribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	intact:EBI-850066(exp-evidence)|pubmed:12806117(see-also)|wwpdb:4Y97(subset)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|evidence ontology:"ECO:0000353"|complex portal:CPX-2087(complex-primary)|pubmed:26975377(see-also)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0003697"(single-stranded DNA binding)	-	-	curated-complex:"Initiates DNA replication by synthesizing short RNA primers on the leading and lagging strand templates in a minimum of five steps: template binding, NTP binding, dinucleotide formation, extension to a functional RNA primer, and primer transfer to the POLA catalytic site for elongation into hybrid primers of about 35 nucleotides."|complex-assembly:Heterotetramer	figure legend:Figure 1,2|comment:NSP1s had no effect.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/18	-	-	-	false	sufficient binding region:?-?	strep tag:n-n|strep tag:n-n|his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-27125556	intact:EBI-27125561	-	-	psi-mi:dna45(display_short)|psi-mi:EBI-27125556(display_long)	psi-mi:rna13(display_short)|psi-mi:EBI-27125561(display_long)	psi-mi:"MI:0699"(rna directed dna polymerase assay)	Kilkenny et al. (2021)	pubmed:34719824|imex:IM-29359	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27125535|imex:IM-29359-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0680"(single stranded deoxyribonucleic acid)	psi-mi:"MI:0320"(ribonucleic acid)	-	-	-	-	-	figure legend:Figure 1,2|comment:NSP1s had no effect.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/12	2021/11/18	-	-	-	false	sufficient binding region:?-?	sufficient binding region:?-?|fluorescein label:1-1	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)