#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1	uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-25492095	intact:EBI-25475864	psi-mi:r1ab_sars2(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	MacDonald et al. (2021)	imex:IM-29179|pubmed:34437808	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27075122|wwpdb:7mgr|imex:IM-29179-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:7LZY|rcsb pdb:7LZZ|rcsb pdb:7M00|rcsb pdb:7M01|rcsb pdb:7M02|rcsb pdb:7M03|rcsb pdb:7M04|rcsb pdb:7M8M|rcsb pdb:7M8N|rcsb pdb:7M8O|rcsb pdb:7M8P|rcsb pdb:7M8X|rcsb pdb:7M8Y|rcsb pdb:7M8Z|rcsb pdb:7M90|rcsb pdb:7M91|rcsb pdb:7MBG|rcsb pdb:7MC5|rcsb pdb:7MC6|rcsb pdb:7ME0|rcsb pdb:7MGR|rcsb pdb:7MGS|rcsb pdb:7MHF|rcsb pdb:7MHG|rcsb pdb:7LKD|rcsb pdb:7LKE|rcsb pdb:7LW3|rcsb pdb:7LW4|rcsb pdb:7LYH|rcsb pdb:7LYI|rcsb pdb:7LZT|rcsb pdb:7LZU|rcsb pdb:7LZV|rcsb pdb:7LZW|rcsb pdb:7LZX|rcsb pdb:7MHH|rcsb pdb:7MHI|rcsb pdb:7MHJ|rcsb pdb:7MHK|rcsb pdb:7MHL|rcsb pdb:7MHM|rcsb pdb:7MHN|rcsb pdb:7MHO|rcsb pdb:7MHP|rcsb pdb:7MHQ|rcsb pdb:7MNG|rcsb pdb:7MPB|rcsb pdb:7MRR|rcsb pdb:7MSW|rcsb pdb:7MSX|rcsb pdb:7N06|rcsb pdb:7N33|rcsb pdb:7N5Z|rcsb pdb:7N6N|rcsb pdb:7N89|rcsb pdb:7N8C|rcsb pdb:7NF5|rcsb pdb:7NG3|rcsb pdb:7NG6|rcsb pdb:7NIO|rcsb pdb:7NN0|rcsb pdb:7NNG|rcsb pdb:7O7Y|rcsb pdb:7O7Z|rcsb pdb:7O80|rcsb pdb:7O81|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:5ROB|rcsb pdb:5SA4|rcsb pdb:5SA5|rcsb pdb:5SA6|rcsb pdb:5SA7|rcsb pdb:7BAL|rcsb pdb:7CA8|rcsb pdb:7CAM|rcsb pdb:7CB7|rcsb pdb:7CUT|rcsb pdb:7CUU|rcsb pdb:7D7K|rcsb pdb:7D7L|rcsb pdb:7DIY|rcsb pdb:7E18|rcsb pdb:7E19|rcsb pdb:7EQ4|rcsb pdb:7JSU|rcsb pdb:7JT0|rcsb pdb:7JT7|rcsb pdb:5SA8|rcsb pdb:5SA9|rcsb pdb:5SAA|rcsb pdb:5SAB|rcsb pdb:5SAC|rcsb pdb:5SAD|rcsb pdb:5SAE|rcsb pdb:5SAF|rcsb pdb:5SAG|rcsb pdb:5SAH|rcsb pdb:5SAI|rcsb pdb:7BAJ|rcsb pdb:7BAK|rcsb pdb:7JW8|rcsb pdb:7K0R|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044174"(host cell endosome)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|rcsb pdb:7BQY|rcsb pdb:7BRO|rcsb pdb:7BRP|rcsb pdb:7BTF|rcsb pdb:7BUY|rcsb pdb:7BV1|rcsb pdb:7BV2|refseq:YP_009724389.1|rcsb pdb:6YZ1|rcsb pdb:6WOJ|rcsb pdb:6WNP|rcsb pdb:6WQ3|rcsb pdb:6WQD|rcsb pdb:6WQF|rcsb pdb:6WRH|rcsb pdb:6WRZ|rcsb pdb:6WTC|rcsb pdb:6WTJ|rcsb pdb:6WTK|rcsb pdb:6WTM|rcsb pdb:6WTT|rcsb pdb:6WUU|rcsb pdb:6WVN|rcsb pdb:6WX4|rcsb pdb:6WXC|rcsb pdb:6WXD|rcsb pdb:6YNQ|rcsb pdb:6YVA|rcsb pdb:6YVF|rcsb pdb:6YWK|rcsb pdb:6YWL|rcsb pdb:6YWM|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|rcsb pdb:5R8T|rcsb pdb:5RG1|rcsb pdb:5RG2|rcsb pdb:5RG3|rcsb pdb:5RGG|rcsb pdb:5RGH|rcsb pdb:5RGI|rcsb pdb:5RGJ|rcsb pdb:5RGK|rcsb pdb:5RGL|rcsb pdb:5RGM|rcsb pdb:5RGN|rcsb pdb:5RGO|rcsb pdb:5RGP|rcsb pdb:5RGQ|rcsb pdb:5RGR|rcsb pdb:5RGS|rcsb pdb:6LZE|rcsb pdb:6M0K|rcsb pdb:6M2N|rcsb pdb:6M2Q|rcsb pdb:6M71|rcsb pdb:6VXS|rcsb pdb:6W4B|rcsb pdb:6W4H|rcsb pdb:6W9C|rcsb pdb:6W9Q|rcsb pdb:6WCF|rcsb pdb:6WEN|rcsb pdb:6WEY|rcsb pdb:6WIQ|rcsb pdb:6WJT|rcsb pdb:6WKQ|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|rcsb pdb:6WKS|rcsb pdb:6WLC|rcsb pdb:7AQE|rcsb pdb:7BB2|rcsb pdb:7BE7|rcsb pdb:7BFB|rcsb pdb:7BGP|rcsb pdb:7JST|rcsb pdb:7K0F|rcsb pdb:7KXB|rcsb pdb:7L0D|rcsb pdb:7L10|rcsb pdb:7L11|rcsb pdb:7L12|rcsb pdb:7L13|rcsb pdb:5RV6|rcsb pdb:5RV7|rcsb pdb:5RV8|rcsb pdb:5RV9|rcsb pdb:5RVA|rcsb pdb:5RVB|rcsb pdb:5RVC|rcsb pdb:5RVD|rcsb pdb:5RVE|rcsb pdb:5RVF|rcsb pdb:5RVG|rcsb pdb:5RVH|rcsb pdb:5RVI|rcsb pdb:5RVJ|rcsb pdb:5RVK|rcsb pdb:5RVL|rcsb pdb:5RVM|rcsb pdb:5RVN|rcsb pdb:5RVO|rcsb pdb:5RVP|rcsb pdb:5RVQ|rcsb pdb:5RVR|rcsb pdb:5RVS|rcsb pdb:5RVT|rcsb pdb:5RVU|rcsb pdb:5RV1|rcsb pdb:5RVV|rcsb pdb:5S18|rcsb pdb:5S1A|rcsb pdb:5S1C|rcsb pdb:5S1E|rcsb pdb:5S1G|rcsb pdb:5RV2|rcsb pdb:5RV3|rcsb pdb:5RV4|rcsb pdb:5S1I|rcsb pdb:5RV5|rcsb pdb:5S1K|rcsb pdb:5S1M|rcsb pdb:5S1O|rcsb pdb:5S1Q|rcsb pdb:7BF6|rcsb pdb:7JPY|rcsb pdb:7JPZ|rcsb pdb:7JQ0|rcsb pdb:7JQ1|rcsb pdb:7JQ2|rcsb pdb:7JQ3|rcsb pdb:7JQ4|rcsb pdb:7JQ5|rcsb pdb:7JQB|rcsb pdb:7BF5|rcsb pdb:7JQC|rcsb pdb:7KEG|rcsb pdb:7KEH|rcsb pdb:7KF4|rcsb pdb:7KOA|rcsb pdb:7KPH|rcsb pdb:7KQO|rcsb pdb:7KQP|rcsb pdb:7KQW|rcsb pdb:7KR0|rcsb pdb:7KR1|rcsb pdb:7KVL|rcsb pdb:7KVR|rcsb pdb:7KX5|rcsb pdb:7KYU|rcsb pdb:7L5D|rcsb pdb:7L6R|rcsb pdb:7L6T|rcsb pdb:7LDX|rcsb pdb:7L14|rcsb pdb:5S1U|rcsb pdb:5S1W|rcsb pdb:5S1Y|rcsb pdb:5S20|rcsb pdb:5S22|rcsb pdb:5S24|rcsb pdb:5S26|rcsb pdb:5S27|rcsb pdb:5S28|rcsb pdb:5S29|rcsb pdb:5S2A|rcsb pdb:5S2B|rcsb pdb:5S2C|rcsb pdb:5S2D|rcsb pdb:5S2E|rcsb pdb:5S2F|rcsb pdb:5S2G|rcsb pdb:5S2H|rcsb pdb:5S2I|rcsb pdb:5S2J|rcsb pdb:5S2K|rcsb pdb:5S2L|rcsb pdb:5S2M|rcsb pdb:5S2N|rcsb pdb:5S1S|rcsb pdb:5S2O|rcsb pdb:5S2P|rcsb pdb:5S2Q|rcsb pdb:5S2R|rcsb pdb:5S2S|rcsb pdb:5S2T|rcsb pdb:5S2U|rcsb pdb:5S2V|rcsb pdb:5S2W|rcsb pdb:5S2X|rcsb pdb:5S2Y|rcsb pdb:5S2Z|rcsb pdb:5S30|rcsb pdb:5S31|rcsb pdb:5S32|rcsb pdb:5S33|rcsb pdb:5S34|rcsb pdb:5S35|rcsb pdb:5S36|rcsb pdb:5S37|rcsb pdb:5S38|rcsb pdb:5S39|rcsb pdb:5S3A|rcsb pdb:5S3B|interpro:IPR027352|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044389|interpro:IPR044401|rcsb pdb:5RL1|rcsb pdb:5RL2|rcsb pdb:5RL3|rcsb pdb:5RL0|rcsb pdb:5RL4|rcsb pdb:5RL5|rcsb pdb:5RS7|rcsb pdb:5RS8|rcsb pdb:5RS9|rcsb pdb:5RSB|rcsb pdb:5RSC|rcsb pdb:5RSD|rcsb pdb:5RSE|rcsb pdb:5RSF|rcsb pdb:5RSG|rcsb pdb:5RSH|rcsb pdb:5RSI|rcsb pdb:5RSJ|rcsb pdb:5RSK|rcsb pdb:5RSL|rcsb pdb:5RSM|rcsb pdb:5RSN|rcsb pdb:5RSO|rcsb pdb:5RSP|rcsb pdb:5RSQ|rcsb pdb:5S3O|rcsb pdb:5S3P|rcsb pdb:5S3Q|rcsb pdb:5S3R|rcsb pdb:5S3S|rcsb pdb:5S3T|rcsb pdb:5S3U|rcsb pdb:5S3V|rcsb pdb:5S3W|rcsb pdb:5S3X|rcsb pdb:5S3Y|rcsb pdb:5S3Z|rcsb pdb:5S40|rcsb pdb:5S3C|rcsb pdb:5S41|rcsb pdb:5S42|rcsb pdb:5S43|rcsb pdb:5S44|rcsb pdb:5S45|rcsb pdb:5S46|rcsb pdb:5S47|rcsb pdb:5S48|rcsb pdb:5S3D|rcsb pdb:5S49|rcsb pdb:5S4A|rcsb pdb:5S3E|rcsb pdb:5S4B|rcsb pdb:5S4C|rcsb pdb:5S3F|rcsb pdb:5S3G|rcsb pdb:5S3H|rcsb pdb:5S3I|rcsb pdb:5S3J|rcsb pdb:5S3K|rcsb pdb:5S3L|rcsb pdb:5S4D|rcsb pdb:5S4E|rcsb pdb:5S4F|rcsb pdb:5S4G|rcsb pdb:5S4H|rcsb pdb:5S4I|rcsb pdb:5S4J|rcsb pdb:5S4K|rcsb pdb:5S6X|rcsb pdb:5S6Y|rcsb pdb:5S6Z|rcsb pdb:5S3M|rcsb pdb:5S3N|rcsb pdb:5S70|rcsb pdb:5S71|rcsb pdb:5RSR|rcsb pdb:5RSS|rcsb pdb:5RST|rcsb pdb:5RSU|rcsb pdb:5RSV|rcsb pdb:5RSW|rcsb pdb:5RSX|rcsb pdb:5RSY|rcsb pdb:5RSZ|rcsb pdb:5RT0|rcsb pdb:5RT1|rcsb pdb:5RT2|rcsb pdb:5RT3|rcsb pdb:5RT4|rcsb pdb:5RT5|rcsb pdb:5RT6|rcsb pdb:5RT7|rcsb pdb:5RT8|rcsb pdb:5RT9|rcsb pdb:5RTA|rcsb pdb:5RTB|rcsb pdb:5RTC|rcsb pdb:5RTD|rcsb pdb:5RTE|rcsb pdb:5RTF|rcsb pdb:5RTG|rcsb pdb:5RTH|rcsb pdb:7ALI|rcsb pdb:7AMJ|rcsb pdb:7ANS|rcsb pdb:7AP6|rcsb pdb:7APH|rcsb pdb:7AQI|rcsb pdb:7AQJ|rcsb pdb:7AR5|rcsb pdb:7AR6|rcsb pdb:5S72|rcsb pdb:5S73|rcsb pdb:5S74|rcsb pdb:6Z5T|rcsb pdb:6Z6I|rcsb pdb:6Z72|rcsb pdb:7A1U|rcsb pdb:7ABU|rcsb pdb:7ADW|rcsb pdb:7AF0|rcsb pdb:7AGA|rcsb pdb:7ARF|rcsb pdb:7AVD|rcsb pdb:7AWR|rcsb pdb:7AWS|rcsb pdb:7AWU|rcsb pdb:7AWW|rcsb pdb:7AX6|rcsb pdb:7AXM|rcsb pdb:7AXO|rcsb pdb:7AY7|rcsb pdb:7AHA|rcsb pdb:7AK4|rcsb pdb:7ALH|rcsb pdb:7B3E|rcsb pdb:7B83|rcsb pdb:7BF3|rcsb pdb:7BF4|rcsb pdb:5RTJ|rcsb pdb:5RTK|rcsb pdb:5RTL|rcsb pdb:5RTM|rcsb pdb:5RTN|rcsb pdb:5RTO|rcsb pdb:5RTP|rcsb pdb:5RTQ|rcsb pdb:5RTR|rcsb pdb:5RTS|rcsb pdb:5RTT|rcsb pdb:5RTI|rcsb pdb:5RTU|rcsb pdb:5RTV|rcsb pdb:5RTW|rcsb pdb:5RTX|rcsb pdb:5RTY|rcsb pdb:5RTZ|rcsb pdb:5RU0|rcsb pdb:5RU1|rcsb pdb:5RU2|rcsb pdb:5RU3|rcsb pdb:5RU4|rcsb pdb:5RU5|rcsb pdb:5RU6|rcsb pdb:5RU7|rcsb pdb:5RU8|rcsb pdb:5RU9|rcsb pdb:5RUA|rcsb pdb:5RUC|rcsb pdb:5RUD|rcsb pdb:5RUE|rcsb pdb:5RUF|rcsb pdb:5RUG|rcsb pdb:5RUH|rcsb pdb:5RUI|rcsb pdb:5RUJ|rcsb pdb:5RUK|rcsb pdb:5RUL|rcsb pdb:5RUM|rcsb pdb:5RUN|rcsb pdb:5RUO|rcsb pdb:5RUP|rcsb pdb:5RUQ|rcsb pdb:5RUR|rcsb pdb:5RUS|rcsb pdb:5RUT|rcsb pdb:5RUU|rcsb pdb:5RUV|rcsb pdb:5RUW|rcsb pdb:5RUX|rcsb pdb:5RUY|rcsb pdb:5RUZ|rcsb pdb:5RV0|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR029063|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR027417|interpro:IPR037227|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042515|interpro:IPR042570|rcsb pdb:6LU7|interpro:IPR037204|rcsb pdb:7LTJ|rcsb pdb:7NBR|rcsb pdb:7NBS|rcsb pdb:7NBY|rcsb pdb:7NEV|rcsb pdb:7NFV|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:5R7Y|rcsb pdb:5R7Z|rcsb pdb:5R80|rcsb pdb:5R81|rcsb pdb:5R82|rcsb pdb:5R83|rcsb pdb:5R84|rcsb pdb:5RE4|rcsb pdb:5RE5|rcsb pdb:5RE6|rcsb pdb:5RE7|rcsb pdb:5RE8|rcsb pdb:5RE9|rcsb pdb:5REA|rcsb pdb:5REB|rcsb pdb:5REC|rcsb pdb:5RED|rcsb pdb:5REE|rcsb pdb:5REF|rcsb pdb:5REG|rcsb pdb:5REH|rcsb pdb:5REI|rcsb pdb:5REJ|rcsb pdb:5REK|rcsb pdb:5REL|rcsb pdb:5REM|rcsb pdb:5REN|rcsb pdb:5REO|rcsb pdb:5REP|rcsb pdb:5RER|rcsb pdb:5RES|rcsb pdb:5RET|rcsb pdb:5REU|rcsb pdb:5REV|rcsb pdb:5REW|rcsb pdb:5REX|rcsb pdb:5REY|rcsb pdb:5REZ|rcsb pdb:5RF0|rcsb pdb:5RF1|rcsb pdb:5RF2|rcsb pdb:5RF3|rcsb pdb:5RF4|rcsb pdb:5RF5|rcsb pdb:5RF6|rcsb pdb:5RF7|rcsb pdb:5RF8|rcsb pdb:5RF9|rcsb pdb:5RFA|rcsb pdb:5RFB|rcsb pdb:5RFC|rcsb pdb:5RFD|rcsb pdb:5RFE|rcsb pdb:5RFF|rcsb pdb:5RFG|rcsb pdb:5RFH|rcsb pdb:5RFI|rcsb pdb:5RFJ|rcsb pdb:5RFK|rcsb pdb:5RFL|rcsb pdb:5RFM|rcsb pdb:5RFN|rcsb pdb:5RFO|rcsb pdb:5RFP|rcsb pdb:5RFQ|rcsb pdb:5RFR|rcsb pdb:5RFS|rcsb pdb:5RFT|rcsb pdb:5RFU|rcsb pdb:5RFV|rcsb pdb:5RFW|rcsb pdb:5RFX|rcsb pdb:5RFY|rcsb pdb:5RFZ|rcsb pdb:5RG0|rcsb pdb:6M03|rcsb pdb:6VWW|rcsb pdb:6W01|rcsb pdb:6W02|rcsb pdb:6W61|rcsb pdb:6W63|rcsb pdb:6W6Y|rcsb pdb:6W75|rcsb pdb:6Y2E|rcsb pdb:6Y2F|rcsb pdb:6Y2G|rcsb pdb:6Y84|rcsb pdb:6YB7|rcsb pdb:7LBS|rcsb pdb:7LFE|rcsb pdb:7L1F|rcsb pdb:7LB7|rcsb pdb:7LBN|rcsb pdb:7LFP|rcsb pdb:7LFZ|rcsb pdb:7LBR|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LG7|rcsb pdb:7LGO|rcsb pdb:7LKR|rcsb pdb:7LKS|rcsb pdb:7LKT|rcsb pdb:7LKU|rcsb pdb:7LKV|rcsb pdb:7LKW|rcsb pdb:7LKX|rcsb pdb:7LLF|rcsb pdb:7LLZ|rcsb pdb:7LOS|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR027351|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:5RGT|rcsb pdb:5RGU|rcsb pdb:5RGV|rcsb pdb:5RGW|rcsb pdb:5RGX|rcsb pdb:5RGY|rcsb pdb:5RGZ|rcsb pdb:5RH0|rcsb pdb:5RH1|rcsb pdb:5RH2|rcsb pdb:5RH3|rcsb pdb:5RH4|rcsb pdb:5RH5|rcsb pdb:5RH6|rcsb pdb:5RH7|rcsb pdb:5RH8|rcsb pdb:5RH9|rcsb pdb:5RHA|rcsb pdb:5RHB|rcsb pdb:5RHC|rcsb pdb:5RHD|rcsb pdb:5RHE|rcsb pdb:5RHF|rcsb pdb:6WZU|rcsb pdb:6X1B|rcsb pdb:6X4I|rcsb pdb:6XA4|rcsb pdb:6XA9|rcsb pdb:6XAA|rcsb pdb:6XB0|rcsb pdb:6XB1|rcsb pdb:6XB2|rcsb pdb:6XBG|rcsb pdb:6XBH|rcsb pdb:6XBI|rcsb pdb:6XCH|rcsb pdb:6XDH|rcsb pdb:6XFN|rcsb pdb:6XG3|rcsb pdb:6XHM|rcsb pdb:6XHU|rcsb pdb:6XIP|rcsb pdb:6XKF|rcsb pdb:6XKH|rcsb pdb:6XKM|rcsb pdb:6XMK|rcsb pdb:6XOA|rcsb pdb:6XQS|rcsb pdb:6XQT|rcsb pdb:6XQU|rcsb pdb:6YYT|rcsb pdb:6Z2E|rcsb pdb:6ZCT|rcsb pdb:6ZOJ|rcsb pdb:7BQ7|rcsb pdb:7C2I|rcsb pdb:7C2J|rcsb pdb:7C8R|rcsb pdb:7C8T|rcsb pdb:7C8U|rcsb pdb:6WC1|rcsb pdb:6XR3|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZN5|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZRT|rcsb pdb:6ZRU|rcsb pdb:6ZSL|rcsb pdb:7BZF|rcsb pdb:7C2K|rcsb pdb:7C2Q|rcsb pdb:7C2Y|rcsb pdb:7C6S|rcsb pdb:7C6U|rcsb pdb:7C7P|rcsb pdb:7C8B|rcsb pdb:7CBT|rcsb pdb:7CJD|rcsb pdb:7CJM|rcsb pdb:7CMD|rcsb pdb:7COM|rcsb pdb:7JFQ|rcsb pdb:7JHE|rcsb pdb:7JIB|rcsb pdb:7JME|rcsb pdb:7JPE|rcsb pdb:7JR3|rcsb pdb:7JR4|rcsb pdb:7JU7|rcsb pdb:7JUN|rcsb pdb:7JYC|rcsb pdb:5RL6|rcsb pdb:5RL7|rcsb pdb:5RL8|rcsb pdb:5RL9|rcsb pdb:5RLB|rcsb pdb:5RLC|rcsb pdb:5RLD|rcsb pdb:5RLE|rcsb pdb:5RLF|rcsb pdb:5RLG|rcsb pdb:5RLH|rcsb pdb:5RLI|rcsb pdb:5RLJ|rcsb pdb:5RLK|rcsb pdb:5RLL|rcsb pdb:5RLM|rcsb pdb:5RLN|rcsb pdb:5RLO|rcsb pdb:5RLP|rcsb pdb:5RLQ|rcsb pdb:5RLR|rcsb pdb:5RLS|rcsb pdb:5RLT|rcsb pdb:5RLU|rcsb pdb:5RLV|rcsb pdb:5RLW|rcsb pdb:5RLY|rcsb pdb:5RLZ|rcsb pdb:5RM0|rcsb pdb:5RM1|rcsb pdb:5RM2|rcsb pdb:5RM3|rcsb pdb:5RM4|rcsb pdb:5RM5|rcsb pdb:5RM6|rcsb pdb:5RM7|rcsb pdb:5RM8|rcsb pdb:5RM9|rcsb pdb:5RMA|rcsb pdb:5RMB|rcsb pdb:5RMC|rcsb pdb:5RMD|rcsb pdb:5RME|rcsb pdb:5RMF|rcsb pdb:5RMG|rcsb pdb:5RMH|rcsb pdb:5RMI|rcsb pdb:5RMJ|rcsb pdb:5RMK|rcsb pdb:5RML|rcsb pdb:5RMM|rcsb pdb:6ZPE|rcsb pdb:7AKU|rcsb pdb:7CWC|rcsb pdb:7CWB|rcsb pdb:7CX9|rcsb pdb:7D1M|rcsb pdb:7D1O|rcsb pdb:7JKV|rcsb pdb:7JOY|rcsb pdb:7JP1|rcsb pdb:7JVZ|rcsb pdb:7JYY|rcsb pdb:7JZ0|rcsb pdb:7K1L|rcsb pdb:7K1O|rcsb pdb:7K3N|rcsb pdb:7K3T|rcsb pdb:7K40|rcsb pdb:7K5I|rcsb pdb:7K6D|rcsb pdb:7K6E|rcsb pdb:7K7P|rcsb pdb:7K9P|rcsb pdb:7KAG|rcsb pdb:7KFI|rcsb pdb:7KG3|rcsb pdb:7KHP|reactome:R-HSA-9694271|reactome:R-HSA-9694301|reactome:R-HSA-9694676|reactome:R-HSA-9694686|reactome:R-HSA-9694786	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:Table S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/27	2021/08/30	rogid:wCJ3ZPKZG00c5axKHF8thiOgR6Q2697049	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:tkUuLuqbTFjX0OZIPB1CF+Rvbf8	false	sufficient binding region:4136-4144	mutation:145-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:P0DTD1	intact:EBI-25475864	intact:EBI-25492095	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:r1ab_sars2(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	MacDonald et al. (2021)	imex:IM-29179|pubmed:34437808	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27075128|wwpdb:7mgs|imex:IM-29179-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	rcsb pdb:7LZY|rcsb pdb:7LZZ|rcsb pdb:7M00|rcsb pdb:7M01|rcsb pdb:7M02|rcsb pdb:7M03|rcsb pdb:7M04|rcsb pdb:7M8M|rcsb pdb:7M8N|rcsb pdb:7M8O|rcsb pdb:7M8P|rcsb pdb:7M8X|rcsb pdb:7M8Y|rcsb pdb:7M8Z|rcsb pdb:7M90|rcsb pdb:7M91|rcsb pdb:7MBG|rcsb pdb:7MC5|rcsb pdb:7MC6|rcsb pdb:7ME0|rcsb pdb:7MGR|rcsb pdb:7MGS|rcsb pdb:7MHF|rcsb pdb:7MHG|rcsb pdb:7LKD|rcsb pdb:7LKE|rcsb pdb:7LW3|rcsb pdb:7LW4|rcsb pdb:7LYH|rcsb pdb:7LYI|rcsb pdb:7LZT|rcsb pdb:7LZU|rcsb pdb:7LZV|rcsb pdb:7LZW|rcsb pdb:7LZX|rcsb pdb:7MHH|rcsb pdb:7MHI|rcsb pdb:7MHJ|rcsb pdb:7MHK|rcsb pdb:7MHL|rcsb pdb:7MHM|rcsb pdb:7MHN|rcsb pdb:7MHO|rcsb pdb:7MHP|rcsb pdb:7MHQ|rcsb pdb:7MNG|rcsb pdb:7MPB|rcsb pdb:7MRR|rcsb pdb:7MSW|rcsb pdb:7MSX|rcsb pdb:7N06|rcsb pdb:7N33|rcsb pdb:7N5Z|rcsb pdb:7N6N|rcsb pdb:7N89|rcsb pdb:7N8C|rcsb pdb:7NF5|rcsb pdb:7NG3|rcsb pdb:7NG6|rcsb pdb:7NIO|rcsb pdb:7NN0|rcsb pdb:7NNG|rcsb pdb:7O7Y|rcsb pdb:7O7Z|rcsb pdb:7O80|rcsb pdb:7O81|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:5ROB|rcsb pdb:5SA4|rcsb pdb:5SA5|rcsb pdb:5SA6|rcsb pdb:5SA7|rcsb pdb:7BAL|rcsb pdb:7CA8|rcsb pdb:7CAM|rcsb pdb:7CB7|rcsb pdb:7CUT|rcsb pdb:7CUU|rcsb pdb:7D7K|rcsb pdb:7D7L|rcsb pdb:7DIY|rcsb pdb:7E18|rcsb pdb:7E19|rcsb pdb:7EQ4|rcsb pdb:7JSU|rcsb pdb:7JT0|rcsb pdb:7JT7|rcsb pdb:5SA8|rcsb pdb:5SA9|rcsb pdb:5SAA|rcsb pdb:5SAB|rcsb pdb:5SAC|rcsb pdb:5SAD|rcsb pdb:5SAE|rcsb pdb:5SAF|rcsb pdb:5SAG|rcsb pdb:5SAH|rcsb pdb:5SAI|rcsb pdb:7BAJ|rcsb pdb:7BAK|rcsb pdb:7JW8|rcsb pdb:7K0R|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019079"(viral genome replication)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039519"(modulation by virus of host autophagy)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044174"(host cell endosome)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|rcsb pdb:7BQY|rcsb pdb:7BRO|rcsb pdb:7BRP|rcsb pdb:7BTF|rcsb pdb:7BUY|rcsb pdb:7BV1|rcsb pdb:7BV2|refseq:YP_009724389.1|rcsb pdb:6YZ1|rcsb pdb:6WOJ|rcsb pdb:6WNP|rcsb pdb:6WQ3|rcsb pdb:6WQD|rcsb pdb:6WQF|rcsb pdb:6WRH|rcsb pdb:6WRZ|rcsb pdb:6WTC|rcsb pdb:6WTJ|rcsb pdb:6WTK|rcsb pdb:6WTM|rcsb pdb:6WTT|rcsb pdb:6WUU|rcsb pdb:6WVN|rcsb pdb:6WX4|rcsb pdb:6WXC|rcsb pdb:6WXD|rcsb pdb:6YNQ|rcsb pdb:6YVA|rcsb pdb:6YVF|rcsb pdb:6YWK|rcsb pdb:6YWL|rcsb pdb:6YWM|interpro:IPR043502|interpro:IPR043503|interpro:IPR043504|rcsb pdb:5R8T|rcsb pdb:5RG1|rcsb pdb:5RG2|rcsb pdb:5RG3|rcsb pdb:5RGG|rcsb pdb:5RGH|rcsb pdb:5RGI|rcsb pdb:5RGJ|rcsb pdb:5RGK|rcsb pdb:5RGL|rcsb pdb:5RGM|rcsb pdb:5RGN|rcsb pdb:5RGO|rcsb pdb:5RGP|rcsb pdb:5RGQ|rcsb pdb:5RGR|rcsb pdb:5RGS|rcsb pdb:6LZE|rcsb pdb:6M0K|rcsb pdb:6M2N|rcsb pdb:6M2Q|rcsb pdb:6M71|rcsb pdb:6VXS|rcsb pdb:6W4B|rcsb pdb:6W4H|rcsb pdb:6W9C|rcsb pdb:6W9Q|rcsb pdb:6WCF|rcsb pdb:6WEN|rcsb pdb:6WEY|rcsb pdb:6WIQ|rcsb pdb:6WJT|rcsb pdb:6WKQ|interpro:IPR013016(Peptidase C30/C16)|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|rcsb pdb:6WKS|rcsb pdb:6WLC|rcsb pdb:7AQE|rcsb pdb:7BB2|rcsb pdb:7BE7|rcsb pdb:7BFB|rcsb pdb:7BGP|rcsb pdb:7JST|rcsb pdb:7K0F|rcsb pdb:7KXB|rcsb pdb:7L0D|rcsb pdb:7L10|rcsb pdb:7L11|rcsb pdb:7L12|rcsb pdb:7L13|rcsb pdb:5RV6|rcsb pdb:5RV7|rcsb pdb:5RV8|rcsb pdb:5RV9|rcsb pdb:5RVA|rcsb pdb:5RVB|rcsb pdb:5RVC|rcsb pdb:5RVD|rcsb pdb:5RVE|rcsb pdb:5RVF|rcsb pdb:5RVG|rcsb pdb:5RVH|rcsb pdb:5RVI|rcsb pdb:5RVJ|rcsb pdb:5RVK|rcsb pdb:5RVL|rcsb pdb:5RVM|rcsb pdb:5RVN|rcsb pdb:5RVO|rcsb pdb:5RVP|rcsb pdb:5RVQ|rcsb pdb:5RVR|rcsb pdb:5RVS|rcsb pdb:5RVT|rcsb pdb:5RVU|rcsb pdb:5RV1|rcsb pdb:5RVV|rcsb pdb:5S18|rcsb pdb:5S1A|rcsb pdb:5S1C|rcsb pdb:5S1E|rcsb pdb:5S1G|rcsb pdb:5RV2|rcsb pdb:5RV3|rcsb pdb:5RV4|rcsb pdb:5S1I|rcsb pdb:5RV5|rcsb pdb:5S1K|rcsb pdb:5S1M|rcsb pdb:5S1O|rcsb pdb:5S1Q|rcsb pdb:7BF6|rcsb pdb:7JPY|rcsb pdb:7JPZ|rcsb pdb:7JQ0|rcsb pdb:7JQ1|rcsb pdb:7JQ2|rcsb pdb:7JQ3|rcsb pdb:7JQ4|rcsb pdb:7JQ5|rcsb pdb:7JQB|rcsb pdb:7BF5|rcsb pdb:7JQC|rcsb pdb:7KEG|rcsb pdb:7KEH|rcsb pdb:7KF4|rcsb pdb:7KOA|rcsb pdb:7KPH|rcsb pdb:7KQO|rcsb pdb:7KQP|rcsb pdb:7KQW|rcsb pdb:7KR0|rcsb pdb:7KR1|rcsb pdb:7KVL|rcsb pdb:7KVR|rcsb pdb:7KX5|rcsb pdb:7KYU|rcsb pdb:7L5D|rcsb pdb:7L6R|rcsb pdb:7L6T|rcsb pdb:7LDX|rcsb pdb:7L14|rcsb pdb:5S1U|rcsb pdb:5S1W|rcsb pdb:5S1Y|rcsb pdb:5S20|rcsb pdb:5S22|rcsb pdb:5S24|rcsb pdb:5S26|rcsb pdb:5S27|rcsb pdb:5S28|rcsb pdb:5S29|rcsb pdb:5S2A|rcsb pdb:5S2B|rcsb pdb:5S2C|rcsb pdb:5S2D|rcsb pdb:5S2E|rcsb pdb:5S2F|rcsb pdb:5S2G|rcsb pdb:5S2H|rcsb pdb:5S2I|rcsb pdb:5S2J|rcsb pdb:5S2K|rcsb pdb:5S2L|rcsb pdb:5S2M|rcsb pdb:5S2N|rcsb pdb:5S1S|rcsb pdb:5S2O|rcsb pdb:5S2P|rcsb pdb:5S2Q|rcsb pdb:5S2R|rcsb pdb:5S2S|rcsb pdb:5S2T|rcsb pdb:5S2U|rcsb pdb:5S2V|rcsb pdb:5S2W|rcsb pdb:5S2X|rcsb pdb:5S2Y|rcsb pdb:5S2Z|rcsb pdb:5S30|rcsb pdb:5S31|rcsb pdb:5S32|rcsb pdb:5S33|rcsb pdb:5S34|rcsb pdb:5S35|rcsb pdb:5S36|rcsb pdb:5S37|rcsb pdb:5S38|rcsb pdb:5S39|rcsb pdb:5S3A|rcsb pdb:5S3B|interpro:IPR027352|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|interpro:IPR044367|interpro:IPR044371|interpro:IPR044389|interpro:IPR044401|rcsb pdb:5RL1|rcsb pdb:5RL2|rcsb pdb:5RL3|rcsb pdb:5RL0|rcsb pdb:5RL4|rcsb pdb:5RL5|rcsb pdb:5RS7|rcsb pdb:5RS8|rcsb pdb:5RS9|rcsb pdb:5RSB|rcsb pdb:5RSC|rcsb pdb:5RSD|rcsb pdb:5RSE|rcsb pdb:5RSF|rcsb pdb:5RSG|rcsb pdb:5RSH|rcsb pdb:5RSI|rcsb pdb:5RSJ|rcsb pdb:5RSK|rcsb pdb:5RSL|rcsb pdb:5RSM|rcsb pdb:5RSN|rcsb pdb:5RSO|rcsb pdb:5RSP|rcsb pdb:5RSQ|rcsb pdb:5S3O|rcsb pdb:5S3P|rcsb pdb:5S3Q|rcsb pdb:5S3R|rcsb pdb:5S3S|rcsb pdb:5S3T|rcsb pdb:5S3U|rcsb pdb:5S3V|rcsb pdb:5S3W|rcsb pdb:5S3X|rcsb pdb:5S3Y|rcsb pdb:5S3Z|rcsb pdb:5S40|rcsb pdb:5S3C|rcsb pdb:5S41|rcsb pdb:5S42|rcsb pdb:5S43|rcsb pdb:5S44|rcsb pdb:5S45|rcsb pdb:5S46|rcsb pdb:5S47|rcsb pdb:5S48|rcsb pdb:5S3D|rcsb pdb:5S49|rcsb pdb:5S4A|rcsb pdb:5S3E|rcsb pdb:5S4B|rcsb pdb:5S4C|rcsb pdb:5S3F|rcsb pdb:5S3G|rcsb pdb:5S3H|rcsb pdb:5S3I|rcsb pdb:5S3J|rcsb pdb:5S3K|rcsb pdb:5S3L|rcsb pdb:5S4D|rcsb pdb:5S4E|rcsb pdb:5S4F|rcsb pdb:5S4G|rcsb pdb:5S4H|rcsb pdb:5S4I|rcsb pdb:5S4J|rcsb pdb:5S4K|rcsb pdb:5S6X|rcsb pdb:5S6Y|rcsb pdb:5S6Z|rcsb pdb:5S3M|rcsb pdb:5S3N|rcsb pdb:5S70|rcsb pdb:5S71|rcsb pdb:5RSR|rcsb pdb:5RSS|rcsb pdb:5RST|rcsb pdb:5RSU|rcsb pdb:5RSV|rcsb pdb:5RSW|rcsb pdb:5RSX|rcsb pdb:5RSY|rcsb pdb:5RSZ|rcsb pdb:5RT0|rcsb pdb:5RT1|rcsb pdb:5RT2|rcsb pdb:5RT3|rcsb pdb:5RT4|rcsb pdb:5RT5|rcsb pdb:5RT6|rcsb pdb:5RT7|rcsb pdb:5RT8|rcsb pdb:5RT9|rcsb pdb:5RTA|rcsb pdb:5RTB|rcsb pdb:5RTC|rcsb pdb:5RTD|rcsb pdb:5RTE|rcsb pdb:5RTF|rcsb pdb:5RTG|rcsb pdb:5RTH|rcsb pdb:7ALI|rcsb pdb:7AMJ|rcsb pdb:7ANS|rcsb pdb:7AP6|rcsb pdb:7APH|rcsb pdb:7AQI|rcsb pdb:7AQJ|rcsb pdb:7AR5|rcsb pdb:7AR6|rcsb pdb:5S72|rcsb pdb:5S73|rcsb pdb:5S74|rcsb pdb:6Z5T|rcsb pdb:6Z6I|rcsb pdb:6Z72|rcsb pdb:7A1U|rcsb pdb:7ABU|rcsb pdb:7ADW|rcsb pdb:7AF0|rcsb pdb:7AGA|rcsb pdb:7ARF|rcsb pdb:7AVD|rcsb pdb:7AWR|rcsb pdb:7AWS|rcsb pdb:7AWU|rcsb pdb:7AWW|rcsb pdb:7AX6|rcsb pdb:7AXM|rcsb pdb:7AXO|rcsb pdb:7AY7|rcsb pdb:7AHA|rcsb pdb:7AK4|rcsb pdb:7ALH|rcsb pdb:7B3E|rcsb pdb:7B83|rcsb pdb:7BF3|rcsb pdb:7BF4|rcsb pdb:5RTJ|rcsb pdb:5RTK|rcsb pdb:5RTL|rcsb pdb:5RTM|rcsb pdb:5RTN|rcsb pdb:5RTO|rcsb pdb:5RTP|rcsb pdb:5RTQ|rcsb pdb:5RTR|rcsb pdb:5RTS|rcsb pdb:5RTT|rcsb pdb:5RTI|rcsb pdb:5RTU|rcsb pdb:5RTV|rcsb pdb:5RTW|rcsb pdb:5RTX|rcsb pdb:5RTY|rcsb pdb:5RTZ|rcsb pdb:5RU0|rcsb pdb:5RU1|rcsb pdb:5RU2|rcsb pdb:5RU3|rcsb pdb:5RU4|rcsb pdb:5RU5|rcsb pdb:5RU6|rcsb pdb:5RU7|rcsb pdb:5RU8|rcsb pdb:5RU9|rcsb pdb:5RUA|rcsb pdb:5RUC|rcsb pdb:5RUD|rcsb pdb:5RUE|rcsb pdb:5RUF|rcsb pdb:5RUG|rcsb pdb:5RUH|rcsb pdb:5RUI|rcsb pdb:5RUJ|rcsb pdb:5RUK|rcsb pdb:5RUL|rcsb pdb:5RUM|rcsb pdb:5RUN|rcsb pdb:5RUO|rcsb pdb:5RUP|rcsb pdb:5RUQ|rcsb pdb:5RUR|rcsb pdb:5RUS|rcsb pdb:5RUT|rcsb pdb:5RUU|rcsb pdb:5RUV|rcsb pdb:5RUW|rcsb pdb:5RUX|rcsb pdb:5RUY|rcsb pdb:5RUZ|rcsb pdb:5RV0|interpro:IPR002589(Appr-1-p processing)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR014822(Nsp9 replicase)|interpro:IPR014828(Nsp7 replicase)|interpro:IPR014829(Nsp8 replicase)|interpro:IPR018995|interpro:IPR021590|interpro:IPR022733|interpro:IPR024358|interpro:IPR024375|interpro:IPR029063|interpro:IPR032505|interpro:IPR032592|interpro:IPR036333|interpro:IPR036499|interpro:IPR027417|interpro:IPR037227|interpro:IPR037230|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR042515|interpro:IPR042570|rcsb pdb:6LU7|interpro:IPR037204|rcsb pdb:7LTJ|rcsb pdb:7NBR|rcsb pdb:7NBS|rcsb pdb:7NBY|rcsb pdb:7NEV|rcsb pdb:7NFV|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:5R7Y|rcsb pdb:5R7Z|rcsb pdb:5R80|rcsb pdb:5R81|rcsb pdb:5R82|rcsb pdb:5R83|rcsb pdb:5R84|rcsb pdb:5RE4|rcsb pdb:5RE5|rcsb pdb:5RE6|rcsb pdb:5RE7|rcsb pdb:5RE8|rcsb pdb:5RE9|rcsb pdb:5REA|rcsb pdb:5REB|rcsb pdb:5REC|rcsb pdb:5RED|rcsb pdb:5REE|rcsb pdb:5REF|rcsb pdb:5REG|rcsb pdb:5REH|rcsb pdb:5REI|rcsb pdb:5REJ|rcsb pdb:5REK|rcsb pdb:5REL|rcsb pdb:5REM|rcsb pdb:5REN|rcsb pdb:5REO|rcsb pdb:5REP|rcsb pdb:5RER|rcsb pdb:5RES|rcsb pdb:5RET|rcsb pdb:5REU|rcsb pdb:5REV|rcsb pdb:5REW|rcsb pdb:5REX|rcsb pdb:5REY|rcsb pdb:5REZ|rcsb pdb:5RF0|rcsb pdb:5RF1|rcsb pdb:5RF2|rcsb pdb:5RF3|rcsb pdb:5RF4|rcsb pdb:5RF5|rcsb pdb:5RF6|rcsb pdb:5RF7|rcsb pdb:5RF8|rcsb pdb:5RF9|rcsb pdb:5RFA|rcsb pdb:5RFB|rcsb pdb:5RFC|rcsb pdb:5RFD|rcsb pdb:5RFE|rcsb pdb:5RFF|rcsb pdb:5RFG|rcsb pdb:5RFH|rcsb pdb:5RFI|rcsb pdb:5RFJ|rcsb pdb:5RFK|rcsb pdb:5RFL|rcsb pdb:5RFM|rcsb pdb:5RFN|rcsb pdb:5RFO|rcsb pdb:5RFP|rcsb pdb:5RFQ|rcsb pdb:5RFR|rcsb pdb:5RFS|rcsb pdb:5RFT|rcsb pdb:5RFU|rcsb pdb:5RFV|rcsb pdb:5RFW|rcsb pdb:5RFX|rcsb pdb:5RFY|rcsb pdb:5RFZ|rcsb pdb:5RG0|rcsb pdb:6M03|rcsb pdb:6VWW|rcsb pdb:6W01|rcsb pdb:6W02|rcsb pdb:6W61|rcsb pdb:6W63|rcsb pdb:6W6Y|rcsb pdb:6W75|rcsb pdb:6Y2E|rcsb pdb:6Y2F|rcsb pdb:6Y2G|rcsb pdb:6Y84|rcsb pdb:6YB7|rcsb pdb:7LBS|rcsb pdb:7LFE|rcsb pdb:7L1F|rcsb pdb:7LB7|rcsb pdb:7LBN|rcsb pdb:7LFP|rcsb pdb:7LFZ|rcsb pdb:7LBR|rcsb pdb:7LG2|rcsb pdb:7LG3|rcsb pdb:7LG7|rcsb pdb:7LGO|rcsb pdb:7LKR|rcsb pdb:7LKS|rcsb pdb:7LKT|rcsb pdb:7LKU|rcsb pdb:7LKV|rcsb pdb:7LKW|rcsb pdb:7LKX|rcsb pdb:7LLF|rcsb pdb:7LLZ|rcsb pdb:7LOS|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR027351|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:5RGT|rcsb pdb:5RGU|rcsb pdb:5RGV|rcsb pdb:5RGW|rcsb pdb:5RGX|rcsb pdb:5RGY|rcsb pdb:5RGZ|rcsb pdb:5RH0|rcsb pdb:5RH1|rcsb pdb:5RH2|rcsb pdb:5RH3|rcsb pdb:5RH4|rcsb pdb:5RH5|rcsb pdb:5RH6|rcsb pdb:5RH7|rcsb pdb:5RH8|rcsb pdb:5RH9|rcsb pdb:5RHA|rcsb pdb:5RHB|rcsb pdb:5RHC|rcsb pdb:5RHD|rcsb pdb:5RHE|rcsb pdb:5RHF|rcsb pdb:6WZU|rcsb pdb:6X1B|rcsb pdb:6X4I|rcsb pdb:6XA4|rcsb pdb:6XA9|rcsb pdb:6XAA|rcsb pdb:6XB0|rcsb pdb:6XB1|rcsb pdb:6XB2|rcsb pdb:6XBG|rcsb pdb:6XBH|rcsb pdb:6XBI|rcsb pdb:6XCH|rcsb pdb:6XDH|rcsb pdb:6XFN|rcsb pdb:6XG3|rcsb pdb:6XHM|rcsb pdb:6XHU|rcsb pdb:6XIP|rcsb pdb:6XKF|rcsb pdb:6XKH|rcsb pdb:6XKM|rcsb pdb:6XMK|rcsb pdb:6XOA|rcsb pdb:6XQS|rcsb pdb:6XQT|rcsb pdb:6XQU|rcsb pdb:6YYT|rcsb pdb:6Z2E|rcsb pdb:6ZCT|rcsb pdb:6ZOJ|rcsb pdb:7BQ7|rcsb pdb:7C2I|rcsb pdb:7C2J|rcsb pdb:7C8R|rcsb pdb:7C8T|rcsb pdb:7C8U|rcsb pdb:6WC1|rcsb pdb:6XR3|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZN5|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZRT|rcsb pdb:6ZRU|rcsb pdb:6ZSL|rcsb pdb:7BZF|rcsb pdb:7C2K|rcsb pdb:7C2Q|rcsb pdb:7C2Y|rcsb pdb:7C6S|rcsb pdb:7C6U|rcsb pdb:7C7P|rcsb pdb:7C8B|rcsb pdb:7CBT|rcsb pdb:7CJD|rcsb pdb:7CJM|rcsb pdb:7CMD|rcsb pdb:7COM|rcsb pdb:7JFQ|rcsb pdb:7JHE|rcsb pdb:7JIB|rcsb pdb:7JME|rcsb pdb:7JPE|rcsb pdb:7JR3|rcsb pdb:7JR4|rcsb pdb:7JU7|rcsb pdb:7JUN|rcsb pdb:7JYC|rcsb pdb:5RL6|rcsb pdb:5RL7|rcsb pdb:5RL8|rcsb pdb:5RL9|rcsb pdb:5RLB|rcsb pdb:5RLC|rcsb pdb:5RLD|rcsb pdb:5RLE|rcsb pdb:5RLF|rcsb pdb:5RLG|rcsb pdb:5RLH|rcsb pdb:5RLI|rcsb pdb:5RLJ|rcsb pdb:5RLK|rcsb pdb:5RLL|rcsb pdb:5RLM|rcsb pdb:5RLN|rcsb pdb:5RLO|rcsb pdb:5RLP|rcsb pdb:5RLQ|rcsb pdb:5RLR|rcsb pdb:5RLS|rcsb pdb:5RLT|rcsb pdb:5RLU|rcsb pdb:5RLV|rcsb pdb:5RLW|rcsb pdb:5RLY|rcsb pdb:5RLZ|rcsb pdb:5RM0|rcsb pdb:5RM1|rcsb pdb:5RM2|rcsb pdb:5RM3|rcsb pdb:5RM4|rcsb pdb:5RM5|rcsb pdb:5RM6|rcsb pdb:5RM7|rcsb pdb:5RM8|rcsb pdb:5RM9|rcsb pdb:5RMA|rcsb pdb:5RMB|rcsb pdb:5RMC|rcsb pdb:5RMD|rcsb pdb:5RME|rcsb pdb:5RMF|rcsb pdb:5RMG|rcsb pdb:5RMH|rcsb pdb:5RMI|rcsb pdb:5RMJ|rcsb pdb:5RMK|rcsb pdb:5RML|rcsb pdb:5RMM|rcsb pdb:6ZPE|rcsb pdb:7AKU|rcsb pdb:7CWC|rcsb pdb:7CWB|rcsb pdb:7CX9|rcsb pdb:7D1M|rcsb pdb:7D1O|rcsb pdb:7JKV|rcsb pdb:7JOY|rcsb pdb:7JP1|rcsb pdb:7JVZ|rcsb pdb:7JYY|rcsb pdb:7JZ0|rcsb pdb:7K1L|rcsb pdb:7K1O|rcsb pdb:7K3N|rcsb pdb:7K3T|rcsb pdb:7K40|rcsb pdb:7K5I|rcsb pdb:7K6D|rcsb pdb:7K6E|rcsb pdb:7K7P|rcsb pdb:7K9P|rcsb pdb:7KAG|rcsb pdb:7KFI|rcsb pdb:7KG3|rcsb pdb:7KHP|reactome:R-HSA-9694271|reactome:R-HSA-9694301|reactome:R-HSA-9694676|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:Table S1|caution:The PDBe entry for the Nsp4/5 entry has the sequence SAVLQSGFR  rather than the stated sequence as given in the Methods - which is AVLQSGFRK.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/27	2021/08/30	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:wCJ3ZPKZG00c5axKHF8thiOgR6Q2697049	rigid:tkUuLuqbTFjX0OZIPB1CF+Rvbf8	false	mutation:145-145	sufficient binding region:3260-3268	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-27075162	uniprotkb:P0DTD1-PRO_0000449623	-	intact:EBI-25475864	psi-mi:nsp4/5 peptide(display_short)|psi-mi:EBI-27075162(display_long)	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:"MI:0990"(cleavage assay)	MacDonald et al. (2021)	imex:IM-29179|pubmed:34437808	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27075159|imex:IM-29179-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	uniprotkb:P0DTD1(see-also)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	-	-	chain-seq-start:3264|chain-seq-end:3569	figure legend:Table 1, Fig. S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:1.3x10^4(per mole per second)	2021/08/27	2021/08/30	rogid:5paWG8TKpS+Vdd4uWaMMBd0QUBk-2	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rigid:AjyLX86/Ie8uYIiN31Zn33cnUmk	false	tag:c-c|fluorophore:n-n	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P0DTD1-PRO_0000449623	intact:EBI-27075181	intact:EBI-25475864	-	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:nsp8/9(display_short)|psi-mi:EBI-27075181(display_long)	psi-mi:"MI:0990"(cleavage assay)	MacDonald et al. (2021)	imex:IM-29179|pubmed:34437808	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27075174|imex:IM-29179-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	uniprotkb:P0C6X1(see-also)|uniprotkb:P0C6X5(see-also)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:Table 1, Fig. S1|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:3.6x10^2(per mole per second)	2021/08/27	2021/08/30	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:IfYLsrlek9C8Qsqmi6QKan6YROs-2	rigid:OO3X1U3EJfB8WzVYImhtSDFYqQg	false	-	tag:c-c|fluorophore:n-n|mutation increasing interaction rate:8-8|mutation increasing interaction rate:9-9|mutation disrupting interaction rate:8-8|mutation decreasing interaction rate:9-9	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)