#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054991|imex:IM-29149-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3A, Supp. figure 3C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	flag tag:?-?|sufficient binding region:276-484	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057227|imex:IM-29149-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:5I, Supp. 5 C/E/F|comment:The association between GSDMD or chimeric GSDMD  and nucleocapsid was slightly diminished when the linker region was replaced.|comment:GSDMD truncations lacking the p20/p10  interacting regions were still able to interact with nucleocapsid.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	flag tag:?-?|sufficient binding region:1-301,311-349,369-484|sufficient binding region:276-484|sufficient binding region:1-264	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9D8T2	uniprotkb:P0DTC9	intact:EBI-16177955|ensembl:ENSMUSP00000023238|uniprotkb:Q3TBD9	intact:EBI-25475856	psi-mi:gsdmd_mouse(display_long)|uniprotkb:Gsdmd(gene name)|psi-mi:Gsdmd(display_short)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:Gsdmdc1(gene name synonym)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057552|imex:IM-29149-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:6AO3|rcsb pdb:6KMV|rcsb pdb:6N9N|rcsb pdb:6VIE|reactome:R-MMU-111457|reactome:R-MMU-448706|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|go:"GO:0035915"(pore formation in membrane of another organism)|ensembl:ENSMUSG00000022575(gene)|ensembl:ENSMUST00000023238(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|refseq:NP_081236.1|dip:DIP-61777N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:Supp. figure 3B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/07/27	2021/08/06	rogid:pLM7kb37QmbkWdISHgXm1UtRV9U10090	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:mDGDdjZl+RSoHewtf7jP+YrX47g	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055376|imex:IM-29149-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3B|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	flag tag:?-?|sufficient binding region:276-484	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055386|imex:IM-29149-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057132|imex:IM-29149-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:5E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	glutathione s tranferase tag:n-n|sufficient binding region:270-280	his tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055477|imex:IM-29149-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3D, Supp. figure 3E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055506|imex:IM-29149-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3E|agonist:"LPS  and  Nigericin (CHEBI:7569)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-thp-1)|taxid:9606(Homo sapiens acute monocytic leukemia cells)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055704|imex:IM-29149-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3F|agonist:"LPS  and  Nigericin (CHEBI:7569)"|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27055780|imex:IM-29149-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3H|comment:All seven nucleocapsid fragments interacted with the GSDMD C-terminus. Fragments containing amino acids 70-160 and 290-360 had the highest binding affinity for GSDMD.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2021/07/27	2021/08/05	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29466	uniprotkb:P57764	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0435"(protease assay)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057047|imex:IM-29149-11	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	-	-	-	figure legend:4G|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:eclYVAhBoZo6ziUMOtXB9O4QPhE	false	sufficient binding region:?-?|his tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29466	uniprotkb:P57764	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0435"(protease assay)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057059|imex:IM-29149-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	-	-	-	figure legend:"4G, (5 G/H)"|comment:Full-length GSDMD, expressed from 293T cells,  with a substituted or chimeric linker  was cleaved normally by the p20/p10 complex even in the presence of Nucleocapsid.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:WSpJJNH/zbfTNnLM7Oi5paA8pJE	false	sufficient binding region:?-?|his tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29466	uniprotkb:P0DTC9	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-25475856	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057059|imex:IM-29149-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:"4G, (5 G/H)"|comment:Full-length GSDMD, expressed from 293T cells,  with a substituted or chimeric linker  was cleaved normally by the p20/p10 complex even in the presence of Nucleocapsid.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:WSpJJNH/zbfTNnLM7Oi5paA8pJE	false	sufficient binding region:?-?|his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057024|imex:IM-29149-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:3I|comment:Nucleocapsid lacking amino acids 70-160 and 290-360 had a slightly weaker association with GSDMD than full-length nucleocapsid.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	glutathione s tranferase tag:n-n	flag tag:?-?|sufficient binding region:1-69,161-289,361-419	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P29466	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057081|imex:IM-29149-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	-	-	-	figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rigid:WSpJJNH/zbfTNnLM7Oi5paA8pJE	false	glutathione s tranferase tag:n-n	sufficient binding region:?-?|his tag:c-c|mutation:285-285	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057081|imex:IM-29149-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:5A|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:WSpJJNH/zbfTNnLM7Oi5paA8pJE	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29466	uniprotkb:P57764	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057097|imex:IM-29149-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	-	-	-	figure legend:5A, Supp. 5B|comment:GSDMD truncation without both aas 302-310 and aas 350-368 completely lost its capacity to bind the p20/p10 complex. Deletion of one of these regions substantially reduced binding.|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:eclYVAhBoZo6ziUMOtXB9O4QPhE	false	mutation:285-285|sufficient binding region:?-?|his tag:c-c	glutathione s tranferase tag:n-n|necessary binding region:302-310,350-368	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57764	uniprotkb:P0DTC9	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	intact:EBI-25475856	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057114|imex:IM-29149-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	-	-	-	figure legend:5 C/D, Supp. figure 3D,5D, 5G|comment:"GSDMD without the linker region  (aas 265-284) or when it was replaced by  chimeric GSDMD,  bound slightly less nucleocapsid than intact GSDMD."|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/07/27	2021/08/06	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	sufficient binding region:1-301,311-349,369-484|glutathione s tranferase tag:n-n|sufficient binding region:276-484	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P0DTC9	uniprotkb:P57764	intact:EBI-25475856	intact:EBI-2798865|uniprotkb:Q96Q98|uniprotkb:D3DWJ9|uniprotkb:A8K702|ensembl:ENSP00000262580|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012	psi-mi:ncap_sars2(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym)	psi-mi:gsdmd_human(display_long)|uniprotkb:DFNA5L(gene name synonym)|uniprotkb:GSDMDC1(gene name synonym)|uniprotkb:Gasdermin domain-containing protein 1(gene name synonym)|uniprotkb:FKSG10(orf name)|uniprotkb:GSDMD(gene name)|psi-mi:GSDMD(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ma et al. (2021)	imex:IM-29149|pubmed:34296442	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057572|imex:IM-29149-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:7CR5|rcsb pdb:7LGD|rcsb pdb:7LUX|rcsb pdb:7LUZ|rcsb pdb:7LV2|rcsb pdb:7N0I|rcsb pdb:7N0R|rcsb pdb:7R98|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|rcsb pdb:6M3M|rcsb pdb:6WJI|rcsb pdb:6WKP|rcsb pdb:6YI3|rcsb pdb:6YUN|rcsb pdb:7C22|refseq:YP_009724397.2|interpro:IPR043505|interpro:IPR044344|interpro:IPR044345|interpro:IPR001218(Coronavirus nucleocapsid protein)|interpro:IPR037179|interpro:IPR037195|rcsb pdb:7DE1|rcsb pdb:7KGO|rcsb pdb:7KGP|rcsb pdb:7KGQ|rcsb pdb:7KGR|rcsb pdb:7KGS|rcsb pdb:7KGT|rcsb pdb:6VYO|rcsb pdb:6WZO|rcsb pdb:6WZQ|rcsb pdb:6ZCO|rcsb pdb:7CDZ|rcsb pdb:7CE0|rcsb pdb:7ACS|rcsb pdb:7ACT|reactome:R-HSA-9694322|reactome:R-HSA-9694614|reactome:R-HSA-9694631|reactome:R-HSA-9694635|reactome:R-HSA-9694686|reactome:R-HSA-9694786	refseq:NP_001159709.1|refseq:NP_079012.3|ensembl:ENSP00000433209|ensembl:ENSP00000482096|ensembl:ENSP00000488012|ensembl:ENSP00000262580|ensembl:ENSG00000104518(gene)|ensembl:ENSG00000278718(gene)|ensembl:ENST00000262580(transcript)|ensembl:ENST00000526406(transcript)|ensembl:ENST00000615119(transcript)|ensembl:ENST00000631751(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0035915"(pore formation in membrane of another organism)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070269"(pyroptosis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR007677(DFNA5 protein)|interpro:IPR040460|interpro:IPR041263|rcsb pdb:5NH1|rcsb pdb:5WQT|rcsb pdb:6AO4|rcsb pdb:6KN0|rcsb pdb:6N9O|rcsb pdb:6VFE|reactome:R-HSA-111457|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-9660826|dip:DIP-61775N	-	-	-	figure legend:Supp. figure 3F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2021/07/27	2021/08/06	rogid:duUiCXyS98OXMbfCdv4gp2blWT42697049	rogid:5IgV2cdBS2svDkKafoz+oX5Cnsw9606	rigid:qCKEpD+RyIqd/jecBUFlzCVb/r8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)