#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:84832" uniprotkb:O15393 intact:EBI-10635571 intact:EBI-12549863|ensembl:ENSP00000330330|ensembl:ENSP00000389006|ensembl:ENSP00000391216|ensembl:ENSP00000502928|ensembl:ENSP00000503556|ensembl:ENSP00000504705|uniprotkb:A8K6Z8|uniprotkb:B2R8E5|uniprotkb:B7Z459|uniprotkb:D3DSJ2|uniprotkb:F8WES1|uniprotkb:Q6GTK7|uniprotkb:Q9BXX1 psi-mi:boc-gln-ala-arg-methylcoumarin(display_short)|psi-mi:"CHEBI:84832"(display_long) psi-mi:tmps2_human(display_long)|uniprotkb:TMPRSS2(gene name)|psi-mi:TMPRSS2(display_short)|uniprotkb:PRSS10(gene name synonym)|uniprotkb:Serine protease 10(gene name synonym) psi-mi:"MI:0990"(cleavage assay) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947660|imex:IM-28914-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000184012(gene)|ensembl:ENST00000332149(transcript)|ensembl:ENST00000454499(transcript)|ensembl:ENST00000458356(transcript)|ensembl:ENST00000676973(transcript)|ensembl:ENST00000678348(transcript)|ensembl:ENST00000679054(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036772|interpro:IPR043504|rcsb pdb:7MEQ|reactome:R-HSA-9678110|reactome:R-HSA-9694614|refseq:NP_001128571.1|refseq:NP_005647.3|refseq:XP_011528033.1 - - - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/26 2021/04/13 - rogid:dkk7k2z3Oh0S+IUE0Y3dbFcCHL09606 - false - sufficient binding region:106-492|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:84832" uniprotkb:P01009 intact:EBI-10635571 intact:EBI-986224|uniprotkb:Q7M4R2|uniprotkb:Q86U18|uniprotkb:Q86U19|uniprotkb:Q96BF9|uniprotkb:Q96ES1|uniprotkb:Q9P1P0|uniprotkb:A6PX14|uniprotkb:Q0PVP5|uniprotkb:Q13672|uniprotkb:Q53XB8|uniprotkb:Q5U0M1|uniprotkb:B2RDQ8|uniprotkb:Q9UCE6|uniprotkb:Q9UCM3|ensembl:ENSP00000348068|ensembl:ENSP00000376802|ensembl:ENSP00000376803|ensembl:ENSP00000385960|ensembl:ENSP00000390299|ensembl:ENSP00000408474|ensembl:ENSP00000416066|ensembl:ENSP00000416354|ensembl:ENSP00000490054 psi-mi:boc-gln-ala-arg-methylcoumarin(display_short)|psi-mi:"CHEBI:84832"(display_long) psi-mi:a1at_human(display_long)|uniprotkb:Alpha-1 protease inhibitor(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)|uniprotkb:AAT(gene name synonym)|uniprotkb:PI(gene name synonym)|uniprotkb:PRO0684(orf name)|uniprotkb:PRO2209(orf name)|uniprotkb:SERPINA1(gene name)|psi-mi:SERPINA1(display_short)|uniprotkb:Serpin A1(gene name synonym) psi-mi:"MI:0990"(cleavage assay) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947665|imex:IM-28914-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_000286.3|refseq:NP_001002235.1|refseq:NP_001002236.1|refseq:NP_001121172.1|refseq:NP_001121173.1|refseq:NP_001121174.1|refseq:NP_001121175.1|refseq:NP_001121176.1|refseq:NP_001121177.1|refseq:NP_001121178.1|refseq:NP_001121179.1|refseq:XP_016876859.1|dip:DIP-35493N|ensembl:ENSG00000197249(gene)|ensembl:ENST00000355814(transcript)|ensembl:ENST00000393087(transcript)|ensembl:ENST00000393088(transcript)|ensembl:ENST00000404814(transcript)|ensembl:ENST00000437397(transcript)|ensembl:ENST00000440909(transcript)|ensembl:ENST00000448921(transcript)|ensembl:ENST00000449399(transcript)|ensembl:ENST00000636712(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01009|rcsb pdb:1ATU|rcsb pdb:1EZX|rcsb pdb:1HP7|rcsb pdb:1D5S|rcsb pdb:1IZ2|rcsb pdb:1KCT|rcsb pdb:1OO8|rcsb pdb:1OPH|rcsb pdb:1PSI|rcsb pdb:1QLP|rcsb pdb:1QMB|rcsb pdb:2D26|rcsb pdb:2QUG|rcsb pdb:3CWL|rcsb pdb:3CWM|rcsb pdb:3DRM|rcsb pdb:3DRU|rcsb pdb:3NDD|rcsb pdb:3NDF|rcsb pdb:3NE4|rcsb pdb:3T1P|rcsb pdb:4PYW|rcsb pdb:5IO1|rcsb pdb:5NBU|rcsb pdb:5NBV|rcsb pdb:6HX4|rcsb pdb:6I4V|rcsb pdb:6I7U|rcsb pdb:6IAY|rcsb pdb:6ROD|rcsb pdb:7AEL|rcsb pdb:7API|rcsb pdb:7NPK|rcsb pdb:7NPL|rcsb pdb:8API|rcsb pdb:9API|reactome:R-HSA-114608|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-6798695|reactome:R-HSA-8957275 - - - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/26 2021/04/13 - rogid:eIbjQWRWsWv+B28IcSUIKJ+Eros9606 - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01009 uniprotkb:O15393 intact:EBI-986224|uniprotkb:Q7M4R2|uniprotkb:Q86U18|uniprotkb:Q86U19|uniprotkb:Q96BF9|uniprotkb:Q96ES1|uniprotkb:Q9P1P0|uniprotkb:A6PX14|uniprotkb:Q0PVP5|uniprotkb:Q13672|uniprotkb:Q53XB8|uniprotkb:Q5U0M1|uniprotkb:B2RDQ8|uniprotkb:Q9UCE6|uniprotkb:Q9UCM3|ensembl:ENSP00000348068|ensembl:ENSP00000376802|ensembl:ENSP00000376803|ensembl:ENSP00000385960|ensembl:ENSP00000390299|ensembl:ENSP00000408474|ensembl:ENSP00000416066|ensembl:ENSP00000416354|ensembl:ENSP00000490054 intact:EBI-12549863|ensembl:ENSP00000330330|ensembl:ENSP00000389006|ensembl:ENSP00000391216|ensembl:ENSP00000502928|ensembl:ENSP00000503556|ensembl:ENSP00000504705|uniprotkb:A8K6Z8|uniprotkb:B2R8E5|uniprotkb:B7Z459|uniprotkb:D3DSJ2|uniprotkb:F8WES1|uniprotkb:Q6GTK7|uniprotkb:Q9BXX1 psi-mi:a1at_human(display_long)|uniprotkb:Alpha-1 protease inhibitor(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)|uniprotkb:AAT(gene name synonym)|uniprotkb:PI(gene name synonym)|uniprotkb:PRO0684(orf name)|uniprotkb:PRO2209(orf name)|uniprotkb:SERPINA1(gene name)|psi-mi:SERPINA1(display_short)|uniprotkb:Serpin A1(gene name synonym) psi-mi:tmps2_human(display_long)|uniprotkb:TMPRSS2(gene name)|psi-mi:TMPRSS2(display_short)|uniprotkb:PRSS10(gene name synonym)|uniprotkb:Serine protease 10(gene name synonym) psi-mi:"MI:0990"(cleavage assay) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947665|imex:IM-28914-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000286.3|refseq:NP_001002235.1|refseq:NP_001002236.1|refseq:NP_001121172.1|refseq:NP_001121173.1|refseq:NP_001121174.1|refseq:NP_001121175.1|refseq:NP_001121176.1|refseq:NP_001121177.1|refseq:NP_001121178.1|refseq:NP_001121179.1|refseq:XP_016876859.1|dip:DIP-35493N|ensembl:ENSG00000197249(gene)|ensembl:ENST00000355814(transcript)|ensembl:ENST00000393087(transcript)|ensembl:ENST00000393088(transcript)|ensembl:ENST00000404814(transcript)|ensembl:ENST00000437397(transcript)|ensembl:ENST00000440909(transcript)|ensembl:ENST00000448921(transcript)|ensembl:ENST00000449399(transcript)|ensembl:ENST00000636712(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01009|rcsb pdb:1ATU|rcsb pdb:1EZX|rcsb pdb:1HP7|rcsb pdb:1D5S|rcsb pdb:1IZ2|rcsb pdb:1KCT|rcsb pdb:1OO8|rcsb pdb:1OPH|rcsb pdb:1PSI|rcsb pdb:1QLP|rcsb pdb:1QMB|rcsb pdb:2D26|rcsb pdb:2QUG|rcsb pdb:3CWL|rcsb pdb:3CWM|rcsb pdb:3DRM|rcsb pdb:3DRU|rcsb pdb:3NDD|rcsb pdb:3NDF|rcsb pdb:3NE4|rcsb pdb:3T1P|rcsb pdb:4PYW|rcsb pdb:5IO1|rcsb pdb:5NBU|rcsb pdb:5NBV|rcsb pdb:6HX4|rcsb pdb:6I4V|rcsb pdb:6I7U|rcsb pdb:6IAY|rcsb pdb:6ROD|rcsb pdb:7AEL|rcsb pdb:7API|rcsb pdb:7NPK|rcsb pdb:7NPL|rcsb pdb:8API|rcsb pdb:9API|reactome:R-HSA-114608|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-6798695|reactome:R-HSA-8957275 ensembl:ENSG00000184012(gene)|ensembl:ENST00000332149(transcript)|ensembl:ENST00000454499(transcript)|ensembl:ENST00000458356(transcript)|ensembl:ENST00000676973(transcript)|ensembl:ENST00000678348(transcript)|ensembl:ENST00000679054(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036772|interpro:IPR043504|rcsb pdb:7MEQ|reactome:R-HSA-9678110|reactome:R-HSA-9694614|refseq:NP_001128571.1|refseq:NP_005647.3|refseq:XP_011528033.1 - - - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/26 2021/04/13 rogid:eIbjQWRWsWv+B28IcSUIKJ+Eros9606 rogid:dkk7k2z3Oh0S+IUE0Y3dbFcCHL09606 - false - sufficient binding region:106-492|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:84832" chebi:"CHEBI:31347" intact:EBI-10635571 intact:EBI-26947675 psi-mi:boc-gln-ala-arg-methylcoumarin(display_short)|psi-mi:"CHEBI:84832"(display_long) psi-mi:camostat methanesulfonate(display_short)|psi-mi:"CHEBI:31347"(display_long)|intact:Camostat mesilate(synonym)|intact:Camostat monomethanesulfonate(synonym) psi-mi:"MI:0990"(cleavage assay) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947670|imex:IM-28914-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/26 2021/04/13 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:84832" uniprotkb:O15393 intact:EBI-10635571 intact:EBI-12549863|ensembl:ENSP00000330330|ensembl:ENSP00000389006|ensembl:ENSP00000391216|ensembl:ENSP00000502928|ensembl:ENSP00000503556|ensembl:ENSP00000504705|uniprotkb:A8K6Z8|uniprotkb:B2R8E5|uniprotkb:B7Z459|uniprotkb:D3DSJ2|uniprotkb:F8WES1|uniprotkb:Q6GTK7|uniprotkb:Q9BXX1 psi-mi:boc-gln-ala-arg-methylcoumarin(display_short)|psi-mi:"CHEBI:84832"(display_long) psi-mi:tmps2_human(display_long)|uniprotkb:TMPRSS2(gene name)|psi-mi:TMPRSS2(display_short)|uniprotkb:PRSS10(gene name synonym)|uniprotkb:Serine protease 10(gene name synonym) psi-mi:"MI:0990"(cleavage assay) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947670|imex:IM-28914-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000184012(gene)|ensembl:ENST00000332149(transcript)|ensembl:ENST00000454499(transcript)|ensembl:ENST00000458356(transcript)|ensembl:ENST00000676973(transcript)|ensembl:ENST00000678348(transcript)|ensembl:ENST00000679054(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036772|interpro:IPR043504|rcsb pdb:7MEQ|reactome:R-HSA-9678110|reactome:R-HSA-9694614|refseq:NP_001128571.1|refseq:NP_005647.3|refseq:XP_011528033.1 - - - figure legend:5D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2021/03/26 2021/04/13 - rogid:dkk7k2z3Oh0S+IUE0Y3dbFcCHL09606 - false - sufficient binding region:106-492|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P01009 uniprotkb:O15393 intact:EBI-986224|uniprotkb:Q7M4R2|uniprotkb:Q86U18|uniprotkb:Q86U19|uniprotkb:Q96BF9|uniprotkb:Q96ES1|uniprotkb:Q9P1P0|uniprotkb:A6PX14|uniprotkb:Q0PVP5|uniprotkb:Q13672|uniprotkb:Q53XB8|uniprotkb:Q5U0M1|uniprotkb:B2RDQ8|uniprotkb:Q9UCE6|uniprotkb:Q9UCM3|ensembl:ENSP00000348068|ensembl:ENSP00000376802|ensembl:ENSP00000376803|ensembl:ENSP00000385960|ensembl:ENSP00000390299|ensembl:ENSP00000408474|ensembl:ENSP00000416066|ensembl:ENSP00000416354|ensembl:ENSP00000490054 intact:EBI-12549863|ensembl:ENSP00000330330|ensembl:ENSP00000389006|ensembl:ENSP00000391216|ensembl:ENSP00000502928|ensembl:ENSP00000503556|ensembl:ENSP00000504705|uniprotkb:A8K6Z8|uniprotkb:B2R8E5|uniprotkb:B7Z459|uniprotkb:D3DSJ2|uniprotkb:F8WES1|uniprotkb:Q6GTK7|uniprotkb:Q9BXX1 psi-mi:a1at_human(display_long)|uniprotkb:Alpha-1 protease inhibitor(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)|uniprotkb:AAT(gene name synonym)|uniprotkb:PI(gene name synonym)|uniprotkb:PRO0684(orf name)|uniprotkb:PRO2209(orf name)|uniprotkb:SERPINA1(gene name)|psi-mi:SERPINA1(display_short)|uniprotkb:Serpin A1(gene name synonym) psi-mi:tmps2_human(display_long)|uniprotkb:TMPRSS2(gene name)|psi-mi:TMPRSS2(display_short)|uniprotkb:PRSS10(gene name synonym)|uniprotkb:Serine protease 10(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Wettstein et al. (2021) pubmed:33741941|imex:IM-28914 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-26947720|imex:IM-28914-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000286.3|refseq:NP_001002235.1|refseq:NP_001002236.1|refseq:NP_001121172.1|refseq:NP_001121173.1|refseq:NP_001121174.1|refseq:NP_001121175.1|refseq:NP_001121176.1|refseq:NP_001121177.1|refseq:NP_001121178.1|refseq:NP_001121179.1|refseq:XP_016876859.1|dip:DIP-35493N|ensembl:ENSG00000197249(gene)|ensembl:ENST00000355814(transcript)|ensembl:ENST00000393087(transcript)|ensembl:ENST00000393088(transcript)|ensembl:ENST00000404814(transcript)|ensembl:ENST00000437397(transcript)|ensembl:ENST00000440909(transcript)|ensembl:ENST00000448921(transcript)|ensembl:ENST00000449399(transcript)|ensembl:ENST00000636712(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01009|rcsb pdb:1ATU|rcsb pdb:1EZX|rcsb pdb:1HP7|rcsb pdb:1D5S|rcsb pdb:1IZ2|rcsb pdb:1KCT|rcsb pdb:1OO8|rcsb pdb:1OPH|rcsb pdb:1PSI|rcsb pdb:1QLP|rcsb pdb:1QMB|rcsb pdb:2D26|rcsb pdb:2QUG|rcsb pdb:3CWL|rcsb pdb:3CWM|rcsb pdb:3DRM|rcsb pdb:3DRU|rcsb pdb:3NDD|rcsb pdb:3NDF|rcsb pdb:3NE4|rcsb pdb:3T1P|rcsb pdb:4PYW|rcsb pdb:5IO1|rcsb pdb:5NBU|rcsb pdb:5NBV|rcsb pdb:6HX4|rcsb pdb:6I4V|rcsb pdb:6I7U|rcsb pdb:6IAY|rcsb pdb:6ROD|rcsb pdb:7AEL|rcsb pdb:7API|rcsb pdb:7NPK|rcsb pdb:7NPL|rcsb pdb:8API|rcsb pdb:9API|reactome:R-HSA-114608|reactome:R-HSA-204005|reactome:R-HSA-381426|reactome:R-HSA-5694530|reactome:R-HSA-6798695|reactome:R-HSA-8957275 ensembl:ENSG00000184012(gene)|ensembl:ENST00000332149(transcript)|ensembl:ENST00000454499(transcript)|ensembl:ENST00000458356(transcript)|ensembl:ENST00000676973(transcript)|ensembl:ENST00000678348(transcript)|ensembl:ENST00000679054(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036772|interpro:IPR043504|rcsb pdb:7MEQ|reactome:R-HSA-9678110|reactome:R-HSA-9694614|refseq:NP_001128571.1|refseq:NP_005647.3|refseq:XP_011528033.1 - - - figure legend:Supp. figure 8 B/C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:941.0x10^-9(molar) 2021/03/26 2021/04/13 rogid:eIbjQWRWsWv+B28IcSUIKJ+Eros9606 rogid:dkk7k2z3Oh0S+IUE0Y3dbFcCHL09606 rigid:1HiX4eicnqvulxVYk22Ccq4LLjA false - sufficient binding region:106-492|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)