#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99608	uniprotkb:Q6P1N0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-7112364|intact:EBI-28978458|ensembl:ENSP00000313601|ensembl:ENSP00000500461|intact:MINT-4827481|uniprotkb:Q7Z435|uniprotkb:Q86XV0|uniprotkb:Q9H603|uniprotkb:Q8NF89|uniprotkb:Q9NXI1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c2d1a_human(display_long)|uniprotkb:CC2D1A(gene name)|psi-mi:CC2D1A(display_short)|uniprotkb:AKI1(gene name synonym)|uniprotkb:Akt kinase-interacting protein 1(gene name synonym)|uniprotkb:Five prime repressor element under dual repression-binding protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 023N(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000313601|ensembl:ENST00000589606|ensembl:ENSP00000467526|ensembl:ENSP00000500461|ensembl:ENST00000672339|ensembl:ENSP00000500343|ensembl:ENSG00000132024(gene)|ensembl:ENSG00000288293(gene)|ensembl:ENST00000318003(transcript)|ensembl:ENST00000672017(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905381"(negative regulation of snRNA transcription by RNA polymerase II)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006608(Protein of unknown function DM14)|interpro:IPR035892|interpro:IPR037772|interpro:IPR039725|refseq:NP_060191.3|refseq:XP_005260030.1	-	-	comment:mint|comment:homomint|function:"Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell"|function:"Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3) [MIM:608443]. Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs"	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:epJzfetEvVa5rJirbt3Ox8cEkqA9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UKA4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049491|uniprotkb:O75124|uniprotkb:Q9NUK7|ensembl:ENSP00000025301	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:aka11_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 11(gene name synonym)|uniprotkb:A-kinase anchor protein 220 kDa(gene name synonym)|uniprotkb:AKAP11(gene name)|psi-mi:AKAP11(display_short)|uniprotkb:AKAP220(gene name synonym)|uniprotkb:KIAA0629(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_011533205.1|refseq:XP_011533206.1|refseq:XP_011533207.1|refseq:XP_011533208.1|refseq:NP_057332.1|refseq:XP_016875870.1|ensembl:ENSG00000023516(gene)|ensembl:ENST00000025301(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR008382(A-kinase anchor 110 kDa)|mint:Q9UKA4	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:EoQOZuPirXCY2k5migb2Fr6utZ09606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8N3C0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYK2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11110166|ensembl:ENSP00000440901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyk2_human(display_long)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090372(gene)|ensembl:ENST00000539396(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CWwVsvNBEouYub9DRx3ykuw6Wqg9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W726	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955080|ensembl:ENSP00000271877	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w726_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143569(gene)|ensembl:ENST00000271877(transcript)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001317659.1|refseq:XP_016858474.1	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ubziKKFRBd1iMzyzCDu/sNF1+T09606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PPJ0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10177154|ensembl:ENSP00000432655	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9ppj0_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000087365(gene)|ensembl:ENST00000528302(transcript)|go:"GO:0016607"(nuclear speck)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|interpro:IPR007180(Protein of unknown function DUF382)	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nkmgro5nnggAfRRO7SlKnRxSMsU9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BUF6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955067|ensembl:ENSP00000457613	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3buf6_human(display_long)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000564304(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|refseq:NP_001295159.1	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:deregvuN/2hveFXyezm8WFOtXqs9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H0Y2V6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11022356|ensembl:ENSP00000338161	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h0y2v6_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143702(gene)|ensembl:ENST00000336415(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0072686"(mitotic spindle)|interpro:IPR026644|interpro:IPR029300	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JPDQK8U8dVkFcGB/BRM1MK6yL5g9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SFB3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955049|ensembl:ENSP00000486443	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sfb3_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215301(gene)|ensembl:ENST00000626301(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016787"(hydrolase activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3HBCl/lJwdnqa4IyzA2ToiWUcJw9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L1L3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955034|ensembl:ENSP00000458919	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l1l3_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|ensembl:ENSG00000132382(gene)|ensembl:ENST00000573116(transcript)|go:"GO:0003677"(DNA binding)	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nINs4THVlRPw4Bpgit3pSmMPghA9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y2Z0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95905	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2557598|ensembl:ENSP00000362070|uniprotkb:C9JX46|uniprotkb:E9PAW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ecd_human(display_long)|uniprotkb:Human suppressor of GCR two(gene name synonym)|uniprotkb:ECD(gene name)|psi-mi:ECD(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129225.1|refseq:NP_009196.1|ensembl:ENSG00000122882(gene)|ensembl:ENST00000372979(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR010770(SGT1)|refseq:NP_001129224.1	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7uvREpWu7KW0cAo8zcf7SSkaQiY9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EX73	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955017|ensembl:ENSP00000399858	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7ex73_human(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000114867(gene)|ensembl:ENST00000441154(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1qdHA6IrcrYFYKmrDfOt8zNV/W49606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96GA3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558389|uniprotkb:Q96JX8|ensembl:ENSP00000356548	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ltv1_human(display_long)|uniprotkb:LTV1(gene name)|psi-mi:LTV1(display_short)|uniprotkb:C6orf93(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116249.2|ensembl:ENSG00000135521(gene)|ensembl:ENST00000367576(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007307(Low temperature viability protein)|mint:Q96GA3|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|reactome:R-HSA-6791226	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Csfx8GS5hoclLY1BYki/uUKoSIM9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1ANR0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-9977484|ensembl:ENSP00000361953	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WTT1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955001|ensembl:ENSP00000478108	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wtt1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000070756(gene)|ensembl:ENST00000610907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|interpro:IPR000504(RNA recognition motif, RNP-1)	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cK4lGsqOggjFbeqhmhHwrjWSECA9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955093|imex:IM-28889-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:ST1|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:PKH9bVoToY6twCXr3+PK8o8ETEM	false	mutation with complex effect:109-109,110-110|mutation with complex effect:66-66|mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6P2Q9	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:I0ot8b3pvieXRI66omFm145sGVA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UQ80	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-924893|uniprotkb:Q9UM59|uniprotkb:O43846|ensembl:ENSP00000302886	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pa2g4_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)|uniprotkb:Cell cycle protein p38-2G4 homolog(gene name synonym)|uniprotkb:ErbB3-binding protein 1(gene name synonym)|uniprotkb:EBP1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006182.2|dip:DIP-31275N|ensembl:ENSG00000170515(gene)|ensembl:ENST00000303305(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:Q9UQ80|rcsb pdb:2Q8K|rcsb pdb:3J2I|rcsb pdb:6CHT|rcsb pdb:6LSR|rcsb pdb:6SXO|rcsb pdb:6WM8|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-6798695|interpro:IPR018349	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:OGRaz1uHilOnGXaAr/yeKMlCyns9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6P1N0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-7112364|intact:EBI-28978458|ensembl:ENSP00000313601|ensembl:ENSP00000500461|intact:MINT-4827481|uniprotkb:Q7Z435|uniprotkb:Q86XV0|uniprotkb:Q9H603|uniprotkb:Q8NF89|uniprotkb:Q9NXI1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c2d1a_human(display_long)|uniprotkb:CC2D1A(gene name)|psi-mi:CC2D1A(display_short)|uniprotkb:AKI1(gene name synonym)|uniprotkb:Akt kinase-interacting protein 1(gene name synonym)|uniprotkb:Five prime repressor element under dual repression-binding protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 023N(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000313601|ensembl:ENST00000589606|ensembl:ENSP00000467526|ensembl:ENSP00000500461|ensembl:ENST00000672339|ensembl:ENSP00000500343|ensembl:ENSG00000132024(gene)|ensembl:ENSG00000288293(gene)|ensembl:ENST00000318003(transcript)|ensembl:ENST00000672017(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905381"(negative regulation of snRNA transcription by RNA polymerase II)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006608(Protein of unknown function DM14)|interpro:IPR035892|interpro:IPR037772|interpro:IPR039725|refseq:NP_060191.3|refseq:XP_005260030.1	-	-	comment:mint|comment:homomint|function:"Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell"|function:"Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3) [MIM:608443]. Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs"	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:epJzfetEvVa5rJirbt3Ox8cEkqA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q14247	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WY61	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955751|ensembl:ENSP00000481541	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wy61_human(display_long)|uniprotkb:NUMA1(gene name)|psi-mi:NUMA1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000137497(gene)|ensembl:ENST00000616538(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR026650	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KFkRQwFLfb/4P8PTQ6dbLKCJLmo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P11388	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-539628|uniprotkb:Q9HB26|uniprotkb:Q71UN1|uniprotkb:Q71UQ5|uniprotkb:Q9HB24|uniprotkb:Q9HB25|uniprotkb:Q9UP44|uniprotkb:Q9UQP9|uniprotkb:B2RTS1|intact:EBI-2556496|ensembl:ENSP00000411532	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:top2a_human(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:TOP2A(gene name)|psi-mi:TOP2A(display_short)|uniprotkb:TOP2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001058.2|ensembl:ENSG00000131747(gene)|ensembl:ENST00000423485(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:P11388|rcsb pdb:1LWZ|rcsb pdb:1ZXM|rcsb pdb:4FM9|rcsb pdb:4R1F|rcsb pdb:5GWK|rcsb pdb:5NNE|rcsb pdb:6ZY5|rcsb pdb:6ZY6|rcsb pdb:6ZY7|rcsb pdb:6ZY8|reactome:R-HSA-1362277|reactome:R-HSA-4615885|rcsb pdb:1ZXN|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030263"(apoptotic chromosome condensation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|dip:DIP-33887N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WFhFsTLF3XG/CVgT4+TBNCovXiM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13283	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYV5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26886652|ensembl:ENSP00000441406	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyv5_human(display_long)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000182196(gene)|ensembl:ENST00000413381(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0016607"(nuclear speck)|interpro:IPR019532	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:K0OQXPxMErAGbrKM1IKwo9vpRYw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8NC51	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-523558|uniprotkb:Q8WUH0|uniprotkb:Q96SE2|uniprotkb:Q9BTY3|uniprotkb:Q9BUM4|uniprotkb:Q9Y367|uniprotkb:Q9Y4S3|uniprotkb:Q5VU19|intact:EBI-1058614|ensembl:ENSP00000360034|uniprotkb:Q5VU20|uniprotkb:Q5VU22	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pairb_human(display_long)|uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)|uniprotkb:SERPINE1 mRNA-binding protein 1(gene name synonym)|uniprotkb:CGI-55(orf name)|uniprotkb:SERBP1(gene name)|psi-mi:SERBP1(display_short)|uniprotkb:PAIRBP1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000142864(gene)|ensembl:ENST00000370995(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR027205|interpro:IPR032381|interpro:IPR039764|mint:Q8NC51|rcsb pdb:4V6X|rcsb pdb:6Z6M|rcsb pdb:6Z6N|refseq:NP_001018077.1|refseq:NP_001018078.1|refseq:NP_001018079.1|refseq:NP_056455.3|dip:DIP-33819N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lVkIPRkoXs3B4Qop1pA2zG/RKlo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P08243	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-722989|uniprotkb:P08184|uniprotkb:Q15666|uniprotkb:Q549T9|uniprotkb:Q96HD0|ensembl:ENSP00000175506|ensembl:ENSP00000377845|ensembl:ENSP00000377846|uniprotkb:A4D1I8|uniprotkb:D6W5R3|uniprotkb:B4DXZ1|uniprotkb:B7ZAA9|uniprotkb:E9PCI3|uniprotkb:E9PCX6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:asns_human(display_long)|uniprotkb:Glutamine-dependent asparagine synthetase(gene name synonym)|uniprotkb:Cell cycle control protein TS11(gene name synonym)|uniprotkb:ASNS(gene name)|psi-mi:ASNS(display_short)|uniprotkb:TS11(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001171546.1|refseq:NP_001171547.1|refseq:NP_001171548.1|refseq:NP_001664.3|refseq:NP_597680.2|refseq:NP_899199.2|ensembl:ENSG00000070669(gene)|ensembl:ENST00000175506(transcript)|ensembl:ENST00000394308(transcript)|ensembl:ENST00000394309(transcript)|go:"GO:0001889"(liver development)|go:"GO:0004066"("asparagine synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006529"(asparagine biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0031427"(response to methotrexate)|go:"GO:0032354"(response to follicle-stimulating hormone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0070981"(L-asparagine biosynthetic process)|interpro:IPR001962(Asparagine synthase)|interpro:IPR006426(Asparagine synthase, glutamine-hydrolyzing)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017932|interpro:IPR029055|interpro:IPR033738|rcsb pdb:6GQ3|reactome:R-HSA-380994|reactome:R-HSA-8963693|reactome:R-HSA-9633012|reactome:R-HSA-9648895	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:McR8Ve0DzWhe3JWMYLsCRChiBaY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P60174	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-717475|uniprotkb:D3DUS9|uniprotkb:P00938|uniprotkb:Q6IS07|uniprotkb:Q8WWD0|uniprotkb:Q96AG5|uniprotkb:Q6FHP9|uniprotkb:B7Z5D8|ensembl:ENSP00000379933	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tpis_human(display_long)|uniprotkb:Triose-phosphate isomerase(gene name synonym)|uniprotkb:TPI1(gene name)|psi-mi:TPI1(display_short)|uniprotkb:TPI(gene name synonym)|uniprotkb:Methylglyoxal synthase(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000356.1|refseq:NP_001152759.1|refseq:NP_001244955.1|ensembl:ENSG00000111669(gene)|ensembl:ENST00000396705(transcript)|go:"GO:0004807"(triose-phosphate isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008929"(methylglyoxal synthase activity)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000652(Triosephosphate isomerase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR020861|interpro:IPR022896|interpro:IPR035990|mint:P60174|rcsb pdb:1HTI|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1WYI|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2JK2|rcsb pdb:2VOM|rcsb pdb:4BR1|rcsb pdb:4E41|rcsb pdb:4POC|rcsb pdb:4POD|rcsb pdb:4UNK|rcsb pdb:4UNL|rcsb pdb:4ZVJ|rcsb pdb:6C2G|rcsb pdb:6D43|rcsb pdb:6NLH|rcsb pdb:6UP1|rcsb pdb:6UP5|rcsb pdb:6UP8|rcsb pdb:6UPF|reactome:R-HSA-70171|reactome:R-HSA-70263	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FaLt6wGI1Bz2Z81gX35p7sOiMbE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P31942	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P46087	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356811|uniprotkb:A1A4Z3|uniprotkb:Q0P5S5|uniprotkb:Q58F30|uniprotkb:B3KPD6|uniprotkb:Q05BA7|uniprotkb:Q3KQS4|ensembl:ENSP00000313272|ensembl:ENSP00000444437	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nop2_human(display_long)|uniprotkb:NOP2(gene name)|psi-mi:NOP2(display_short)|uniprotkb:NSUN1(gene name synonym)|uniprotkb:Proliferating-cell nucleolar antigen p120(gene name synonym)|uniprotkb:Proliferation-associated nucleolar protein p120(gene name synonym)|uniprotkb:NOL1(gene name synonym)|uniprotkb:Nucleolar protein 2 homolog(gene name synonym)|uniprotkb:Nucleolar protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001028886.1|refseq:NP_006161.2|refseq:NP_001245237.1|refseq:NP_001245238.1|refseq:NP_001245239.1|refseq:XP_005253748.1|ensembl:ENSG00000111641(gene)|ensembl:ENST00000322166(transcript)|ensembl:ENST00000537442(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009383"("rRNA (cytosine-C5-)-methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR011023(Nop2p)|interpro:IPR012586(P120R)|interpro:IPR018314|interpro:IPR023267|interpro:IPR023273|interpro:IPR029063|interpro:IPR031341|mint:P46087|reactome:R-HSA-6790901|reactome:R-HSA-8869496	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CvYaCDv8N8OvS0lPFy8jFEFaOTA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:C9JTK6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955738|ensembl:ENSP00000414568	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c9jtk6_human(display_long)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000138430(gene)|ensembl:ENST00000427472(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR031167	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lSpLv9Vn2bQGtX/ibTZvcFZSLPs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P55010	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-286450|uniprotkb:Q9H5N2|uniprotkb:Q9UG48|uniprotkb:Q53XB3|ensembl:ENSP00000216554|ensembl:ENSP00000376477|ensembl:ENSP00000453743	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if5_human(display_long)|uniprotkb:EIF5(gene name)|psi-mi:EIF5(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001960.2|refseq:NP_892116.2|ensembl:ENSG00000100664(gene)|ensembl:ENST00000216554(transcript)|ensembl:ENST00000392715(transcript)|ensembl:ENST00000558506(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|mint:P55010|rcsb pdb:2E9H|rcsb pdb:2G2K|rcsb pdb:2IU1|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lM5AZJWJOQGbxADfl8MGCx3JAXc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P26196	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8TEP8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2339778|uniprotkb:Q9H0F4|uniprotkb:Q8WYT8|uniprotkb:Q9NW27|uniprotkb:A0A060A9S4|intact:EBI-11329707|uniprotkb:B7ZMF0|uniprotkb:E9PF99|intact:EBI-10984660|ensembl:ENSP00000427550	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ce192_human(display_long)|uniprotkb:CEP192(gene name)|psi-mi:CEP192(display_short)|uniprotkb:KIAA1569(gene name synonym)|uniprotkb:PP8407(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_115518.3|dip:DIP-52779N|ensembl:ENSG00000101639(gene)|ensembl:ENST00000506447(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|rcsb pdb:4N7Z|rcsb pdb:6FVI|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:XXxzXD9dfRTtgx/tKR0VhGAlPWc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O00267	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-710464|ensembl:ENSP00000404029|ensembl:ENSP00000469090|ensembl:ENSP00000470252|uniprotkb:O43279|uniprotkb:Q59G52|uniprotkb:Q99639	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:spt5h_human(display_long)|uniprotkb:DRB sensitivity-inducing factor large subunit(gene name synonym)|uniprotkb:DRB sensitivity-inducing factor 160 kDa subunit(gene name synonym)|uniprotkb:Tat-cotransactivator 1 protein(gene name synonym)|uniprotkb:SUPT5H(gene name)|psi-mi:SUPT5H(display_short)|uniprotkb:SPT5(gene name synonym)|uniprotkb:SPT5H(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001124296.1|refseq:NP_001124297.1|refseq:NP_003160.2|refseq:NP_001104490.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019899"(enzyme binding)|go:"GO:0032044"(DSIF complex)|go:"GO:0032785"(negative regulation of DNA-templated transcription, elongation)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENSG00000196235(gene)|ensembl:ENST00000432763(transcript)|ensembl:ENST00000598725(transcript)|ensembl:ENST00000599117(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR005100(Supt5 repeat)|interpro:IPR005824(KOW)|interpro:IPR006645(Transcription antitermination protein, NusG, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR017071(Transcription elongation factor Spt5)|interpro:IPR022581|interpro:IPR024945|interpro:IPR036735|interpro:IPR039385|interpro:IPR039659|interpro:IPR041973|interpro:IPR041975|interpro:IPR041976|interpro:IPR041977|interpro:IPR041978|interpro:IPR041980|mint:O00267|rcsb pdb:2DO3|rcsb pdb:2E6Z|rcsb pdb:2E70|rcsb pdb:3H7H|rcsb pdb:4L1U|rcsb pdb:5OHO|rcsb pdb:5OHQ|rcsb pdb:5OIK|rcsb pdb:5U98|rcsb pdb:6EQY|rcsb pdb:6ER0|rcsb pdb:6GMH|rcsb pdb:6GML|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-75955|reactome:R-HSA-77075|refseq:NP_001306920.1|refseq:NP_001306919.1|dip:DIP-29014N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8VodOhZyrmNy3xxDTTsB8KugN849606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q7Z2W4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-922540|uniprotkb:Q8TAJ3|uniprotkb:Q96N79|uniprotkb:Q9H8R9|uniprotkb:Q9P0Y7|uniprotkb:Q8IW57|uniprotkb:A4D1R2|uniprotkb:A4D1S4|ensembl:ENSP00000242351	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:zcchv_human(display_long)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_064504.2|refseq:NP_078901.3|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0009615"(response to virus)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036388|interpro:IPR037197|interpro:IPR040954|interpro:IPR041360|mint:Q7Z2W4|rcsb pdb:2X5Y|rcsb pdb:4X52|rcsb pdb:6UEI|rcsb pdb:6UEJ|reactome:R-HSA-6802952|dip:DIP-37896N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13011	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-711968|ensembl:ENSP00000221418|ensembl:ENSP00000489530|uniprotkb:Q8WVX0|uniprotkb:Q96EZ9|uniprotkb:A8K745	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ech1_human(display_long)|uniprotkb:ECH1(gene name)|psi-mi:ECH1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000104823(gene)|ensembl:ENSG00000282853(gene)|ensembl:ENST00000221418(transcript)|ensembl:ENST00000634245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016020"(membrane)|go:"GO:0051750"("delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:Q13011|rcsb pdb:2VRE|reactome:R-HSA-9033241|refseq:NP_001389.2	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:gh0bwdUu9tkSTHWuySCaTXIQGzI9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:K7EP07	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955727|ensembl:ENSP00000467172	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:k7ep07_human(display_long)|uniprotkb:TBCB(gene name)|psi-mi:TBCB(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000105254(gene)|ensembl:ENST00000588385(transcript)|interpro:IPR000626(Ubiquitin)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR029071|interpro:IPR036859	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9XbzUnV4D31ExzF2C7fcOqxjZyQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P33992	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1AK85	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955709|ensembl:ENSP00000264203	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1ak85_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000077549(gene)|ensembl:ENST00000264203(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0030017"(sarcomere)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|refseq:NP_001193470.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:4uVHvlpzDS2F+M2yeW01EAZmqF09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P13489	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9P2J5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:C9JLK0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955696|ensembl:ENSP00000402393	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c9jlk0_human(display_long)|uniprotkb:ATIC(gene name)|psi-mi:ATIC(display_short)|uniprotkb:Bifunctional purine biosynthesis protein ATIC(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000138363(gene)|ensembl:ENST00000413174(transcript)|go:"GO:0003937"(IMP cyclohydrolase activity)|go:"GO:0004643"(phosphoribosylaminoimidazolecarboxamide formyltransferase activity)|go:"GO:0006164"(purine nucleotide biosynthetic process)|interpro:IPR002695(AICARFT/IMPCHase bienzyme)|interpro:IPR011607(MGS-like)|interpro:IPR036914	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:atZH0qPiTLbkizkctinEKJL/Nlc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P35606	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1056534|uniprotkb:B4DZI8|intact:EBI-11019844|ensembl:ENSP00000329419	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:copb2_human(display_long)|uniprotkb:COPB2(gene name)|psi-mi:COPB2(display_short)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004757.1|ensembl:ENSG00000184432(gene)|ensembl:ENST00000333188(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:P35606|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_016863001.1|dip:DIP-27603N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:zkd7lOeV+OvHglnAJg6cXoMhgbg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y6M1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1024419|intact:EBI-1059063|intact:EBI-1237206|uniprotkb:A0A4Z0|uniprotkb:B3FTN2|uniprotkb:B3FTN3|uniprotkb:B3FTN4|ensembl:ENSP00000371634	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if2b2_human(display_long)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma autoantigen p62(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)|uniprotkb:IGF2BP2(gene name)|psi-mi:IGF2BP2(display_short)|uniprotkb:IMP2(gene name synonym)|uniprotkb:VICKZ2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001278801.1|refseq:NP_001278802.1|refseq:NP_001278803.1|refseq:NP_001278804.1|refseq:NP_001007226.1|refseq:NP_006539.3|ensembl:ENSG00000073792(gene)|ensembl:ENST00000382199(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028743|interpro:IPR034843|interpro:IPR035979|interpro:IPR036612|mint:Q9Y6M1|rcsb pdb:2CQH|rcsb pdb:6ROL|reactome:R-HSA-428359|dip:DIP-35539N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:k45UViReMAxCv2cu7+tx+auevQc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96G28	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2654750|uniprotkb:Q53ST9|uniprotkb:Q6UY34|uniprotkb:Q53SF0|intact:EBI-28976235|ensembl:ENSP00000295117	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cfa36_human(display_long)|uniprotkb:CFAP36(gene name)|psi-mi:CFAP36(display_short)|uniprotkb:CCDC104(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 104(gene name synonym)|uniprotkb:UNQ163/PRO189(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001269690.1|ensembl:ENST00000339012|ensembl:ENSP00000342699|ensembl:ENSP00000295117|refseq:NP_542398.3|ensembl:ENSG00000163001(gene)|ensembl:ENST00000349456(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005930"(axoneme)|go:"GO:0031514"(motile cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097546"(ciliary base)|interpro:IPR023379|interpro:IPR038888|interpro:IPR042541|dip:DIP-57013N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JQO4Xpav6rJoF1SOfxInk5Fuibk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1AHC9	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955666|ensembl:ENSP00000384082|ensembl:ENSP00000403679|uniprotkb:F5H1I8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1ahc9_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000196419(gene)|ensembl:ENST00000405506(transcript)|ensembl:ENST00000428575(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043564"("Ku70:Ku80 complex")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|refseq:NP_001275907.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:eAEmELUqPvLoyIzYNFLrPLxQcmQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9NZI8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1053892|uniprotkb:C9JT33|ensembl:ENSP00000290341	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if2b1_human(display_long)|uniprotkb:ZBP1(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 1(gene name synonym)|uniprotkb:Coding region determinant-binding protein(gene name synonym)|uniprotkb:VICKZ family member 1(gene name synonym)|uniprotkb:IGF2BP1(gene name)|psi-mi:IGF2BP1(display_short)|uniprotkb:Zipcode-binding protein 1(gene name synonym)|uniprotkb:CRDBP(gene name synonym)|uniprotkb:VICKZ1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006537.3|refseq:NP_001153895.1|ensembl:ENSG00000159217(gene)|ensembl:ENST00000290341(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010610"(regulation of mRNA stability involved in response to stress)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022013"(pallium cell proliferation in forebrain)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140059"(dendrite arborization)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034837|interpro:IPR034842|interpro:IPR035979|interpro:IPR036612|mint:Q9NZI8|rcsb pdb:3KRM|rcsb pdb:6QEY|reactome:R-HSA-428359|reactome:R-HSA-5687128|dip:DIP-38139N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3Ps/PWWYr0WpYcx3G/AOiQEj+vc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92499	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-358474|ensembl:ENSP00000233084|ensembl:ENSP00000370745|ensembl:ENSP00000413767|ensembl:ENSP00000504080|uniprotkb:B4DME8|uniprotkb:B4DPN6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ddx1_human(display_long)|uniprotkb:DDX1(gene name)|psi-mi:DDX1(display_short)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:DEAD box protein retinoblastoma(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000079785(gene)|ensembl:ENST00000233084(transcript)|ensembl:ENST00000381341(transcript)|ensembl:ENST00000434671(transcript)|ensembl:ENST00000677302(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|refseq:NP_004930.1|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q92499|rcsb pdb:4XW3|reactome:R-HSA-6784531|dip:DIP-38163N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n2Zv07BpuUDT32/ttDzIFXH3yIQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H7C5N8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955657|ensembl:ENSP00000420382	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h7c5n8_human(display_long)|uniprotkb:PRRC2C(gene name)|psi-mi:PRRC2C(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000117523(gene)|ensembl:ENST00000495585(transcript)|interpro:IPR033184	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:QsYk1LSuWcCF//fvE/tIm34HNkg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q15393	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P35580	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W7U8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10965162|ensembl:ENSP00000376933	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w7u8_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006718905.1|ensembl:ENSG00000020922(gene)|ensembl:ENST00000393241(transcript)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|refseq:NP_001317276.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8AQHQnZdfsNWwkFFu6UXiHc0uZ09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P11387	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-876302|ensembl:ENSP00000354522|uniprotkb:Q15610|uniprotkb:Q5TFY3|uniprotkb:Q9UJN0|uniprotkb:O43256|uniprotkb:Q12855|uniprotkb:Q12856|uniprotkb:A8KA78|uniprotkb:E1P5W3	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:top1_human(display_long)|uniprotkb:DNA topoisomerase I(gene name synonym)|uniprotkb:TOP1(gene name)|psi-mi:TOP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000198900(gene)|ensembl:ENST00000361337(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0012501"(programmed cell death)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032922"(circadian regulation of gene expression)|refseq:NP_003277.1|dip:DIP-36356N|go:"GO:0032993"(protein-DNA complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042493"|go:"GO:0043204"(perikaryon)|go:"GO:0097100"(supercoiled DNA binding)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202|mint:P11387|rcsb pdb:1A31|rcsb pdb:1A35|rcsb pdb:1A36|rcsb pdb:1EJ9|rcsb pdb:1K4S|rcsb pdb:1K4T|rcsb pdb:1LPQ|rcsb pdb:1NH3|rcsb pdb:1R49|rcsb pdb:1RR8|rcsb pdb:1RRJ|rcsb pdb:1SC7|rcsb pdb:1SEU|rcsb pdb:1T8I|rcsb pdb:1TL8|reactome:R-HSA-4615885	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:kB+3PVybgNp2mtOmDa7x8sygFuU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A4PB68	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955644|ensembl:ENSP00000481460	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a4pb68_human(display_long)|uniprotkb:GON4L(gene name)|psi-mi:GON4L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000620426(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0030183"(B cell differentiation)|interpro:IPR033277|ensembl:ENSG00000116580(gene)|refseq:NP_115668.4	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JS0OutsWE36cReuftG/2IduvxfE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A8K968	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955612|ensembl:ENSP00000488626	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a8k968_human(display_long)|uniprotkb:EPB41L3(gene name)|psi-mi:EPB41L3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000082397(gene)|ensembl:ENST00000545076(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0030054"(cell junction)|go:"GO:0030866"(cortical actin cytoskeleton organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|refseq:NP_001268464.1|refseq:XP_016881148.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YBOTLLia9spGPZa0qpwssRwXmM09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P15924	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P22102	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P25205	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9P0K7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1023749|uniprotkb:Q6V1W9|uniprotkb:Q7Z5I4|uniprotkb:Q7Z733|uniprotkb:Q9P2L2|uniprotkb:Q9Y3T5|uniprotkb:E9PED3|intact:EBI-2555698|ensembl:ENSP00000265109|ensembl:ENSP00000388725|ensembl:ENSP00000422942	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rai14_human(display_long)|uniprotkb:Ankyrin repeat and coiled-coil structure-containing protein(gene name synonym)|uniprotkb:Retinoic acid-induced protein 14(gene name synonym)|uniprotkb:Novel retinal pigment epithelial cell protein(gene name synonym)|uniprotkb:RAI14(gene name)|psi-mi:RAI14(display_short)|uniprotkb:KIAA1334(gene name synonym)|uniprotkb:NORPEG(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001138992.1|refseq:NP_001138993.1|refseq:NP_001138994.1|refseq:NP_001138995.1|refseq:NP_001138997.1|refseq:NP_056392.2|refseq:XP_011512319.1|refseq:XP_011512320.1|refseq:XP_011512321.1|refseq:XP_011512322.1|refseq:XP_011512323.1|refseq:XP_011512324.1|ensembl:ENSG00000039560(gene)|ensembl:ENST00000265109(transcript)|ensembl:ENST00000428746(transcript)|ensembl:ENST00000503673(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR042420|mint:Q9P0K7|refseq:XP_006714532.1|refseq:XP_016864824.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:m5hQYx6HEi9QEAey1UiNpeAp6tw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P23381	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-721244|uniprotkb:P78535|uniprotkb:Q9UDL3|uniprotkb:A6NGN1|uniprotkb:A6NID3|uniprotkb:Q502Y0|uniprotkb:Q53XB6|uniprotkb:Q9UDI5|ensembl:ENSP00000347495|ensembl:ENSP00000376620|ensembl:ENSP00000451460	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sywc_human(display_long)|uniprotkb:WARS1(gene name)|psi-mi:WARS1(display_short)|uniprotkb:IFI53(gene name synonym)|uniprotkb:Interferon-induced protein 53(gene name synonym)|uniprotkb:Tryptophanyl-tRNA synthetase(gene name synonym)|uniprotkb:WARS(gene name synonym)|uniprotkb:WRS(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004175.2|refseq:NP_776049.1|refseq:NP_998810.1|refseq:NP_998811.1|refseq:XP_011535435.1|refseq:XP_011535437.1|refseq:XP_011535438.1|refseq:XP_005268101.1|ensembl:ENSG00000140105(gene)|ensembl:ENST00000355338(transcript)|ensembl:ENST00000392882(transcript)|ensembl:ENST00000557135(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004830"(tryptophan-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006436"(tryptophanyl-tRNA aminoacylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002306(Tryptophanyl-tRNA synthetase, class Ib)|refseq:XP_006720312.1|refseq:XP_016877116.1|refseq:XP_016877117.1|refseq:XP_016877118.1|dip:DIP-29493N|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1O5T|rcsb pdb:1R6T|rcsb pdb:1R6U|rcsb pdb:1ULH|rcsb pdb:2AKE|rcsb pdb:2AZX|rcsb pdb:2DR2|rcsb pdb:2QUH|rcsb pdb:2QUI|rcsb pdb:2QUJ|rcsb pdb:2QUK|rcsb pdb:5UJI|rcsb pdb:5UJJ|reactome:R-HSA-379716	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:6suwKlk27+kV9FyX3trqGpVJ9xk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:C9J7S3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955597|ensembl:ENSP00000397616	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c9j7s3_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000115866(gene)|ensembl:ENST00000456565(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:/Xdzqj43yCiqhgWO4q1bmgSB+WM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75643	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07814	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:J3KPX7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955584|ensembl:ENSP00000382362	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:j3kpx7_human(display_long)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215021(gene)|ensembl:ENST00000399433(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:W0f+9J1rF/3y0Mfgpyznf3XCJ5I9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75083	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351917|uniprotkb:O75313|uniprotkb:Q8N6E5|uniprotkb:Q9UG05|uniprotkb:Q9UG78|uniprotkb:A8MPU4|uniprotkb:Q9UQE0|uniprotkb:A8K6E9|ensembl:ENSP00000371890|ensembl:ENSP00000427687	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:wdr1_human(display_long)|uniprotkb:WDR1(gene name)|psi-mi:WDR1(display_short)|uniprotkb:Actin-interacting protein 1(gene name synonym)|uniprotkb:NORI-1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005103.2|refseq:NP_059830.1|ensembl:ENSG00000071127(gene)|ensembl:ENST00000382452(transcript)|ensembl:ENST00000499869(transcript)|go:"GO:0002102"(podosome)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0040011"(locomotion)|go:"GO:0042247"(establishment of planar polarity of follicular epithelium)|go:"GO:0042995"(cell projection)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990266"(neutrophil migration)|interpro:IPR001680(WD40 repeat)|interpro:IPR011045(Nitrous oxide reductase, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:O75083|reactome:R-HSA-114608	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ewKq6uA2Wrg/uK31ayOoenA9Gv49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q14683	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8IY81	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-744088|uniprotkb:Q8N3A3|uniprotkb:Q8WXX1|uniprotkb:Q9BWM4|uniprotkb:Q9NXT6|uniprotkb:D3DU22|uniprotkb:B2RCA5|ensembl:ENSP00000396673	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:spb1_human(display_long)|uniprotkb:FTSJ3(gene name)|psi-mi:FTSJ3(display_short)|uniprotkb:SB92(orf name)|uniprotkb:Protein ftsJ homolog 3(gene name synonym)|uniprotkb:Putative rRNA methyltransferase 3(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_060117.3|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR024576|interpro:IPR028589|interpro:IPR029063|mint:Q8IY81|reactome:R-HSA-6791226|ensembl:ENSG00000108592(gene)|ensembl:ENST00000427159(transcript)|go:"GO:0000453"(enzyme-directed rRNA 2'-O-methylation)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000466"("maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008650"("rRNA (uridine-2'-O-)-methyltransferase activity")|go:"GO:0016435"("rRNA (guanine) methyltransferase activity")|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031167"(rRNA methylation)|go:"GO:0062105"(RNA 2'-O-methyltransferase activity)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR012920(Spb1, C-terminal)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KIeyMWn9Zktm5lV7XI7v2bRA8og9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9P035	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A024R4E5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-21357876|ensembl:ENSP00000312042|ensembl:ENSP00000375836|ensembl:ENSP00000375837|uniprotkb:A0A0A0MR28	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a024r4e5_human(display_long)|uniprotkb:HDLBP(gene name)|psi-mi:HDLBP(display_short)|uniprotkb:hCG_33048(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000115677(gene)|ensembl:ENST00000310931(transcript)|ensembl:ENST00000391975(transcript)|ensembl:ENST00000391976(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|refseq:NP_001307894.1|refseq:NP_001307895.1|refseq:NP_005327.1|refseq:NP_976221.1|refseq:XP_005247059.2|refseq:XP_005247060.2|refseq:XP_006712538.1|refseq:XP_011509360.1|refseq:XP_011509362.1|refseq:XP_016859429.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7/o534Gq6pEwojSX5G3eTK5jkS49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:C9J9S3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955567|ensembl:ENSP00000398839	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c9j9s3_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000213639(gene)|ensembl:ENST00000420282(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0051301"(cell division)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:a/FeaA4jAwZwzzxlfENkcp3Iuio9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BU76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-742459|uniprotkb:Q6P5Y0|uniprotkb:Q6ZTZ6|uniprotkb:Q6ZWA6|uniprotkb:Q8IZH3|ensembl:ENSP00000272139	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mmta2_human(display_long)|uniprotkb:MMTAG2(gene name)|psi-mi:MMTAG2(display_short)|uniprotkb:C1orf35(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_077295.1|mint:Q9BU76|reactome:R-HSA-6798695|ensembl:ENSG00000143793(gene)|ensembl:ENST00000272139(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0034774"(secretory granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR019315|interpro:IPR039207	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TwnLhBYwwR6yPCw3sd7g/sPHJd09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96HC4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-751267|uniprotkb:Q8WVK0|uniprotkb:O60705|uniprotkb:A8K6F9|uniprotkb:Q5UW38|uniprotkb:D6RB78|uniprotkb:E9PBF5|uniprotkb:Q56VN4|ensembl:ENSP00000321746	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pdli5_human(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:PDLIM5(gene name)|psi-mi:PDLIM5(display_short)|uniprotkb:L9(orf name)|uniprotkb:ENH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001011515.1|refseq:NP_001011516.1|refseq:NP_006448.4|refseq:NP_001243358.1|mint:Q96HC4|rcsb pdb:2DAR|rcsb pdb:2UZC|reactome:R-HSA-6794361|interpro:IPR036034|ensembl:ENSG00000163110(gene)|ensembl:ENST00000317968(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|go:"GO:0005829"(cytosol)|dip:DIP-34898N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Ngp310yfoOv8KaxchoUc39mj5HE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:M0R0Y3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955543|ensembl:ENSP00000471524|ensembl:ENSP00000486242	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:m0r0y3_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000183207(gene)|ensembl:ENST00000601968(transcript)|ensembl:ENST00000627972(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR042487	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:BV5cdvZzgDT6ZJSf9P+84tB9t9o9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:D6RJE8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955531|ensembl:ENSP00000425689	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:d6rje8_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120705(gene)|ensembl:ENST00000507939(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003747"(translation release factor activity)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR024049	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:bd4GzCt92o2CyHeKu9eeppm69sQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P26639	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BXP5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-712721|uniprotkb:A4D2E5|uniprotkb:A6NK22|uniprotkb:Q32MI4|uniprotkb:Q9Y4S4|ensembl:ENSP00000480421|uniprotkb:O95808|uniprotkb:Q9BWP6|uniprotkb:Q9BXP4|uniprotkb:A4D2E6|uniprotkb:B4DJL4|uniprotkb:B4DZA6|uniprotkb:Q6NT74|uniprotkb:Q8TDQ5	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:srrt_human(display_long)|uniprotkb:SRRT(gene name)|psi-mi:SRRT(display_short)|uniprotkb:ASR2(gene name synonym)|uniprotkb:ARS2(gene name synonym)|uniprotkb:Arsenite-resistance protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000611405(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007042(Arsenite-resistance protein 2)|interpro:IPR021933|interpro:IPR035979|interpro:IPR039727|mint:Q9BXP5|rcsb pdb:5OO6|rcsb pdb:6F7J|rcsb pdb:6F7P|rcsb pdb:6F7S|rcsb pdb:6F8D|reactome:R-HSA-6807505|reactome:R-HSA-72163|ensembl:ENSG00000087087(gene)|refseq:NP_001122324.1|refseq:NP_001122325.1|refseq:NP_001122326.1|refseq:NP_056992.4	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:upRnTwa7LTUzxnbGtfpJUejg2+w9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PK09	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-21264788|ensembl:ENSP00000431734	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9pk09_human(display_long)|uniprotkb:BCLAF1(gene name)|psi-mi:BCLAF1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR026668|interpro:IPR029199|go:"GO:0016607"(nuclear speck)|ensembl:ENSG00000029363(gene)|ensembl:ENST00000529826(transcript)|go:"GO:0006915"(apoptotic process)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:E1N3gVC4N44GblyMGURs8hkJsWA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92616	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P54577	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1048893|uniprotkb:O43276|uniprotkb:Q53EN1|uniprotkb:B3KWK4|uniprotkb:D3DPQ4|ensembl:ENSP00000362576	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syyc_human(display_long)|uniprotkb:YARS1(gene name)|psi-mi:YARS1(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:YARS(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003671.1|ensembl:ENSG00000134684(gene)|ensembl:ENST00000373477(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006437"(tyrosyl-tRNA aminoacylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0016604"(nuclear body)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|rcsb pdb:1N3L|rcsb pdb:1NTG|rcsb pdb:1Q11|rcsb pdb:4Q93|rcsb pdb:4QBT|rcsb pdb:5THH|rcsb pdb:5THL|reactome:R-HSA-379716|dip:DIP-50415N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:y/0Qs8iOgW5w5LVLWnCvowVpEu89606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:J3QLI9	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955521|ensembl:ENSP00000463568	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:j3qli9_human(display_long)|uniprotkb:SNRPD1(gene name)|psi-mi:SNRPD1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000167088(gene)|ensembl:ENST00000582475(transcript)|go:"GO:0006397"(mRNA processing)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+ZY15c++RXF+wMY8JKgGr860JFE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q15365	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L1I8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955513|ensembl:ENSP00000458870	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l1i8_human(display_long)|uniprotkb:SRRM2(gene name)|psi-mi:SRRM2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000167978(gene)|ensembl:ENST00000575009(transcript)|go:"GO:0016607"(nuclear speck)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YFFKTVNbfMrRne8S6lpCc290YJI9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BZE4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1056249|uniprotkb:O95446|uniprotkb:Q9NVJ8|uniprotkb:B3KMC5|uniprotkb:B4DY13|uniprotkb:B7Z7A3|uniprotkb:Q5T3R8|ensembl:ENSP00000354040	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:gtpb4_human(display_long)|uniprotkb:GTPBP4(gene name)|psi-mi:GTPBP4(display_short)|uniprotkb:CRFG(gene name synonym)|uniprotkb:NOG1(gene name synonym)|uniprotkb:Chronic renal failure gene protein(gene name synonym)|uniprotkb:GTP-binding protein NGB(gene name synonym)|uniprotkb:Nucleolar GTP-binding protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_036473.2|ensembl:ENSG00000107937(gene)|ensembl:ENST00000360803(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033342"(negative regulation of collagen binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR010674(Nucleolar GTP-binding 1)|interpro:IPR012973(NOG, C-terminal)|interpro:IPR024926|interpro:IPR027417|interpro:IPR031167|interpro:IPR041623|mint:Q9BZE4|rcsb pdb:6LSS|rcsb pdb:6LU8	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:wTcBrIj6c27um4RnJH81grRgutc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:J3KSR8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25630574|ensembl:ENSP00000462616	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:j3ksr8_human(display_long)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000136450(gene)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|ensembl:ENST00000584668(transcript)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9yt/yQx1nrsSeYFW1PFehGLxQQA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P50542	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-597835|uniprotkb:Q15115|uniprotkb:Q15266|uniprotkb:Q96FN7|uniprotkb:B7ZAD5|uniprotkb:A8K891|uniprotkb:D3DUT8|uniprotkb:B4DZ45|intact:EBI-28971432|ensembl:ENSP00000400647|ensembl:ENSP00000410159|ensembl:ENSP00000499823|ensembl:ENSP00000500509|ensembl:ENSP00000502374	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pex5_human(display_long)|uniprotkb:Peroxisome receptor 1(gene name synonym)|uniprotkb:Peroxisomal C-terminal targeting signal import receptor(gene name synonym)|uniprotkb:PTS1-BP(gene name synonym)|uniprotkb:Peroxin-5(gene name synonym)|uniprotkb:PEX5(gene name)|psi-mi:PEX5(display_short)|uniprotkb:PXR1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000266563|ensembl:ENSP00000266563|ensembl:ENST00000266564|ensembl:ENSP00000266564|ensembl:ENSP00000410159|ensembl:ENST00000434354|ensembl:ENSP00000407401|ensembl:ENSP00000400647|ensembl:ENSP00000500509|ensembl:ENST00000672242|ensembl:ENSP00000500696|ensembl:ENST00000672541|ensembl:ENSP00000500043|ensembl:ENSP00000499823|ensembl:ENST00000672776|ensembl:ENSP00000500230|ensembl:ENSP00000502374|refseq:NP_001287718.1|refseq:XP_011519097.1|refseq:XP_011519099.1|refseq:XP_011519100.1|refseq:XP_011519101.1|refseq:XP_011519102.1|refseq:NP_000310.2|refseq:NP_001124496.1|refseq:NP_001124497.1|refseq:NP_001124498.1|refseq:XP_016875237.1|refseq:XP_016875238.1|refseq:NP_001124495.1|dip:DIP-34654N|refseq:XP_016875239.1|refseq:XP_016875241.1|refseq:XP_016875242.1|refseq:XP_016875243.1|refseq:XP_016875244.1|ensembl:ENSG00000139197(gene)|ensembl:ENSG00000288217(gene)|ensembl:ENST00000420616(transcript)|ensembl:ENST00000455147(transcript)|ensembl:ENST00000671993(transcript)|ensembl:ENST00000672694(transcript)|ensembl:ENST00000675855(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0016561"(protein import into peroxisome matrix, translocation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024111|interpro:IPR024113|mint:P50542|rcsb pdb:1FCH|rcsb pdb:2C0L|rcsb pdb:2C0M|rcsb pdb:2J9Q|rcsb pdb:2W84|rcsb pdb:3R9A|rcsb pdb:4BXU|rcsb pdb:4KXK|rcsb pdb:4KYO|reactome:R-HSA-8866654|reactome:R-HSA-9033241|reactome:R-HSA-9664873	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:eTada01hgbdLE6GcBY29EGX+7QI9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q02790	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7ENZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25629356|ensembl:ENSP00000426923	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7enz3_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000150753(gene)|ensembl:ENST00000515390(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012718(T-complex protein 1, epsilon subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|refseq:NP_001293083.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9oy/TJCq1GBlANvi6Zf9EVFMWyk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9C0C9	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:J3QT28	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25624274|ensembl:ENSP00000383941	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:j3qt28_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000154473(gene)|ensembl:ENST00000407911(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WQUcJCLLJM8BdRnKtYytDzeXzvU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O14654	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356594|ensembl:ENSP00000505547	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H0Y4R1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955493|ensembl:ENSP00000393525	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h0y4r1_human(display_long)|uniprotkb:IMPDH2(gene name)|psi-mi:IMPDH2(display_short)|uniprotkb:IMPDH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000178035(gene)|ensembl:ENST00000429182(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ZDwFczZqUK/eoOb6Uq21VFk0TbE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49411	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-359097|uniprotkb:O15276|ensembl:ENSP00000322439	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:eftu_human(display_long)|uniprotkb:TUFM(gene name)|psi-mi:TUFM(display_short)|uniprotkb:P43(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003312.3|ensembl:ENSG00000178952(gene)|ensembl:ENST00000313511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004541(Translation elongation factor EFTu/EF1A, bacterial and organelle)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|interpro:IPR033720|interpro:IPR041709|mint:P49411|rcsb pdb:7A5G|rcsb pdb:7O9K|reactome:R-HSA-5389840|refseq:XP_016879108.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:pDRPUBUqvFqnh613N8bDTl4sFHc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L397	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955472|ensembl:ENSP00000460284	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l397_human(display_long)|uniprotkb:EIF5A(gene name)|psi-mi:EIF5A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000132507(gene)|ensembl:ENST00000573714(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0043022"(ribosome binding)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045905"(positive regulation of translational termination)|go:"GO:0051028"(mRNA transport)|interpro:IPR001884("Eukaryotic initiation factor 5A hypusine (eIF-5A)")|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR019769|interpro:IPR020189	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0CH0aUV7hnU7ZZA8lQXhnbS0m6M9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BVP2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-641642|uniprotkb:Q96SV6|uniprotkb:Q96SV7|uniprotkb:Q9UJY0|intact:EBI-2559594|intact:EBI-718302|uniprotkb:B2RDC1|uniprotkb:Q5PU80|intact:EBI-28973725|ensembl:ENSP00000395772	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:gnl3_human(display_long)|uniprotkb:Nucleolar GTP-binding protein 3(gene name synonym)|uniprotkb:Nucleostemin(gene name synonym)|uniprotkb:E2-induced gene 3 protein(gene name synonym)|uniprotkb:Novel nucleolar protein 47(gene name synonym)|uniprotkb:GNL3(gene name)|psi-mi:GNL3(display_short)|uniprotkb:E2IG3(gene name synonym)|uniprotkb:NS(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000394799|ensembl:ENSP00000378278|ensembl:ENSP00000395772|refseq:NP_055181.3|refseq:NP_996561.1|refseq:NP_996562.1|ensembl:ENSG00000163938(gene)|ensembl:ENST00000418458(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030496"(midbody)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|interpro:IPR006073(GTP1/OBG)|interpro:IPR014813(GNL3L/Grn1 putative GTPase)|interpro:IPR027417|interpro:IPR030378|mint:Q9BVP2|reactome:R-HSA-6791226	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:c1DgvQoZ51edxvnCa6GFhfNRR7M9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q7Z417	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92997	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H6J7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-721300|uniprotkb:Q96CS8|uniprotkb:Q9BQH4|uniprotkb:Q9BUW5|intact:EBI-947037|uniprotkb:Q7L077|uniprotkb:D3DQQ8|uniprotkb:E9PAX7|ensembl:ENSP00000278460	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ck049_human(display_long)|uniprotkb:C11orf49(gene name)|psi-mi:C11orf49(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001003676.1|refseq:NP_001003677.1|refseq:NP_001003678.1|refseq:NP_077018.1|ensembl:ENSG00000149179(gene)|ensembl:ENST00000278460(transcript)|interpro:IPR038968	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Oao8NIAnfftuY6pDEEtZOEC2Ods9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P19338	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-346967|uniprotkb:Q53SK1|uniprotkb:Q8NB06|uniprotkb:Q9UDG1|uniprotkb:Q9UCF0|intact:EBI-352553|ensembl:ENSP00000318195	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nucl_human(display_long)|uniprotkb:NCL(gene name)|psi-mi:NCL(display_short)|uniprotkb:Protein C23(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005372.2|dip:DIP-89N|ensembl:ENSG00000115053(gene)|ensembl:ENST00000322723(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005938"(cell cortex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P19338|rcsb pdb:2FC8|rcsb pdb:2FC9|rcsb pdb:2KRR|reactome:R-HSA-6791226	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:PbsEnzoLR4dES5SnMwx08Hr6yeo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L1L3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955034|ensembl:ENSP00000458919	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l1l3_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|ensembl:ENSG00000132382(gene)|ensembl:ENST00000573116(transcript)|go:"GO:0003677"(DNA binding)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nINs4THVlRPw4Bpgit3pSmMPghA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P46108	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q7KZF4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EQR4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-3959936|ensembl:ENSP00000376016	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7eqr4_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000092820(gene)|ensembl:ENST00000392177(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0042995"(cell projection)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Tpjd+GXdo0PEHpyrvlhMVm/6opM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P22314	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P63151	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:evS6klM2alZXtMthVsshKkrNgiA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75143	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2798775|ensembl:ENSP00000352500|ensembl:ENSP00000431974|uniprotkb:Q9BRL3|uniprotkb:Q9H8B0|uniprotkb:D3DQQ1|uniprotkb:D3DQQ2|uniprotkb:B4DFI4|uniprotkb:E9PQZ8|uniprotkb:Q53EN6|intact:EBI-28977728	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atg13_human(display_long)|uniprotkb:ATG13(gene name)|psi-mi:ATG13(display_short)|uniprotkb:KIAA0652(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000175224(gene)|ensembl:ENST00000359513(transcript)|ensembl:ENST00000526508(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|interpro:IPR018731|interpro:IPR036570|interpro:IPR040182|mint:O75143|refseq:NP_001333240.1|refseq:NP_001333241.1|refseq:NP_001333242.1|refseq:NP_001333243.1|refseq:NP_001333244.1|refseq:NP_001333245.1|refseq:NP_001333248.1|refseq:NP_001333249.1|refseq:NP_001333250.1|ensembl:ENSP00000352500|ensembl:ENST00000524625|ensembl:ENSP00000433543|ensembl:ENSP00000431974|ensembl:ENST00000528494|ensembl:ENSP00000432412|ensembl:ENST00000529655|ensembl:ENSP00000433756|ensembl:ENST00000530500|ensembl:ENSP00000434390|ensembl:ENST00000683050|ensembl:ENSP00000507809|refseq:NP_001333251.1|refseq:XP_011518795.1|refseq:XP_011518798.1|refseq:XP_011518801.1|refseq:NP_001136145.1|refseq:NP_001192048.1|refseq:NP_001192049.1|refseq:NP_001192050.1|refseq:NP_001192051.1|refseq:NP_055556.2|refseq:NP_001333271.1|refseq:XP_016874088.1|refseq:XP_016874092.1|refseq:XP_016874096.1|refseq:NP_001333252.1|refseq:NP_001333253.1|refseq:NP_001333254.1|refseq:NP_001333255.1|refseq:NP_001333256.1|refseq:NP_001333257.1|refseq:NP_001333258.1|refseq:NP_001333259.1|refseq:NP_001333260.1|refseq:NP_001333261.1|refseq:XP_006718459.1|refseq:XP_005253322.1|refseq:XP_005253323.1|refseq:XP_005253325.1|refseq:NP_001333273.1|refseq:NP_001333275.1|refseq:NP_001333277.1|refseq:NP_001333278.1|refseq:NP_001333279.1|refseq:NP_001333280.1|refseq:NP_001333281.1|refseq:NP_001333282.1|refseq:NP_001333283.1|dip:DIP-60540N|rcsb pdb:3WAO|rcsb pdb:3WAP|rcsb pdb:5C50|rcsb pdb:5XUY|rcsb pdb:5XV1|rcsb pdb:5XV3|rcsb pdb:5XV4|rcsb pdb:5XV6|rcsb pdb:6HYN|reactome:R-HSA-1632852|rcsb pdb:3WAN	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:xlABwrglkoQu3OSb/8yLTQVxN8o9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P21796	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P11021	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13263	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	intact:EBI-11602285	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	-	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:q5szu1_human(display_short)|psi-mi:EBI-11602285(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	uniprotkb:Q5SZU1(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:V74bduYOcefOD2aN0RBu+Vxv6cg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:M0R1V7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25624130|ensembl:ENSP00000472137	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:m0r1v7_human(display_long)|uniprotkb:UBA52(gene name)|psi-mi:UBA52(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000221983(gene)|ensembl:ENST00000599256(transcript)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:N3nwFqnf9I6MgjzQYvNMqT3KcN89606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P50991	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O00148	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-348253|ensembl:ENSP00000242776|uniprotkb:Q9BVP6|uniprotkb:Q9H5W0|intact:EBI-2514455|uniprotkb:Q8N5M0|uniprotkb:B1Q2N1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:dx39a_human(display_long)|uniprotkb:DEAD box protein 39(gene name synonym)|uniprotkb:Nuclear RNA helicase URH49(gene name synonym)|uniprotkb:DDX39A(gene name)|psi-mi:DDX39A(display_short)|uniprotkb:DDX39(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000123136(gene)|ensembl:ENST00000242776(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00148|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0042802"(identical protein binding)|refseq:NP_005795.2|refseq:XP_011525922.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:EOc5EPfkNVMrdfd9Xx/snoOfhas9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0B4J1Z1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1058410|ensembl:ENSP00000400246|ensembl:ENSP00000416516	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0b4j1z1_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:hCG_15878(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000115875(gene)|ensembl:ENST00000425778(transcript)|ensembl:ENST00000425941(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FlUaPKTNM9ESkZtw/Qtlx6pX2Qw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A6NLN1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-21260952|ensembl:ENSP00000342332	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a6nln1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:hCG_20560(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	interpro:IPR021790|interpro:IPR034798|interpro:IPR035001|ensembl:ENSG00000011304(gene)|ensembl:ENST00000350092(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035000|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:u1acIbk3sUtk1Xz36eSvfwApxx09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q12931	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P01023	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-640741|uniprotkb:Q13677|uniprotkb:Q59F47|uniprotkb:Q5QTS0|uniprotkb:Q68DN2|uniprotkb:Q6PIY3|uniprotkb:Q6PN97|ensembl:ENSP00000323929	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a2mg_human(display_long)|uniprotkb:CPAMD5(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5(gene name synonym)|uniprotkb:A2M(gene name)|psi-mi:A2M(display_short)|uniprotkb:FWP007(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000005.2|refseq:NP_001334352.1|refseq:NP_001334353.1|refseq:NP_001334354.1|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR010916(TonB box, conserved site)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:P01023|rcsb pdb:1BV8|rcsb pdb:2P9R|rcsb pdb:4ACQ|rcsb pdb:6TAV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-1474228|reactome:R-HSA-8963896|ensembl:ENSG00000175899(gene)|ensembl:ENST00000318602(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019959"(interleukin-8 binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|dip:DIP-1118N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FClLRDrtOWUx0eBBCUfAocx0Q+49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P13010	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P40926	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-721232|uniprotkb:O43682|uniprotkb:B4DE44|uniprotkb:E9PDB2|uniprotkb:A8K414|uniprotkb:B2RE78|ensembl:ENSP00000327070	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mdhm_human(display_long)|uniprotkb:MDH2(gene name)|psi-mi:MDH2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005909.2|refseq:NP_001269332.1|refseq:NP_001269333.1|ensembl:ENSG00000146701(gene)|ensembl:ENST00000315758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P40926|rcsb pdb:2DFD|rcsb pdb:4WLE|rcsb pdb:4WLF|rcsb pdb:4WLN|rcsb pdb:4WLO|rcsb pdb:4WLU|rcsb pdb:4WLV|reactome:R-HSA-70263|reactome:R-HSA-71403	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Ur2aO+2M7e/ftD8RlhPMHBc8/JU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9P258	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07195	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P00387	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1046040|uniprotkb:O75675|uniprotkb:Q8TDL8|uniprotkb:Q8WTS8|uniprotkb:Q9UEN4|uniprotkb:Q9UEN5|uniprotkb:Q9UL55|uniprotkb:Q9UL56|uniprotkb:B1AHF2|uniprotkb:B7Z7L3|ensembl:ENSP00000338461	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nb5r3_human(display_long)|uniprotkb:Diaphorase-1(gene name synonym)|uniprotkb:CYB5R3(gene name)|psi-mi:CYB5R3(display_short)|uniprotkb:DIA1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001165132.1|refseq:NP_000389.1|refseq:NP_001123291.1|refseq:NP_015565.1|refseq:NP_001165131.1|ensembl:ENSG00000100243(gene)|ensembl:ENST00000352397(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008015"(blood circulation)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043531"(ADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:0071949"(FAD binding)|go:"GO:1903958"(nitric-oxide synthase complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|mint:P00387|rcsb pdb:1M91|rcsb pdb:1UMK|reactome:R-HSA-196836|reactome:R-HSA-211945|reactome:R-HSA-6798695|interpro:IPR039261|dip:DIP-50463N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Q8JTO6AXZ8LE4FXZAzOw2p4b6HY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P00558	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-709599|uniprotkb:A8K4W6|uniprotkb:Q5J7W1|uniprotkb:Q6IBT6|uniprotkb:Q8NI87|uniprotkb:B7Z7A9|ensembl:ENSP00000362413	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pgk1_human(display_long)|uniprotkb:Primer recognition protein 2(gene name synonym)|uniprotkb:Cell migration-inducing gene 10 protein(gene name synonym)|uniprotkb:PGK1(gene name)|psi-mi:PGK1(display_short)|uniprotkb:PGKA(gene name synonym)|uniprotkb:OK/SW-cl.110(orf name)|uniprotkb:MIG10(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000282.1|dip:DIP-33679N|ensembl:ENSG00000102144(gene)|ensembl:ENST00000373316(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P00558|rcsb pdb:2WZB|rcsb pdb:2WZC|rcsb pdb:2WZD|rcsb pdb:2X13|rcsb pdb:2X14|rcsb pdb:2X15|rcsb pdb:2XE6|rcsb pdb:2XE7|rcsb pdb:2XE8|rcsb pdb:2Y3I|rcsb pdb:2YBE|rcsb pdb:2ZGV|rcsb pdb:3C39|rcsb pdb:3C3A|rcsb pdb:3C3B|rcsb pdb:3C3C|rcsb pdb:3ZOZ|rcsb pdb:4AXX|rcsb pdb:4O33|rcsb pdb:5M1R|rcsb pdb:5M3U|rcsb pdb:5M6Z|rcsb pdb:5MXM|rcsb pdb:5NP8|rcsb pdb:5O7D|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:fkyBDnIx/ii6vfJjWJsxWi0piOQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B7Z645	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955456|ensembl:ENSP00000484577|ensembl:ENSP00000506874|ensembl:ENSP00000507008|ensembl:ENSP00000507581|ensembl:ENSP00000507623	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b7z645_human(display_long)|uniprotkb:SYNCRIP(gene name)|psi-mi:SYNCRIP(display_short)|uniprotkb:hCG_401112(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000135316(gene)|ensembl:ENSG00000271793(gene)|ensembl:ENST00000616122(transcript)|ensembl:ENST00000682504(transcript)|ensembl:ENST00000683074(transcript)|ensembl:ENST00000683436(transcript)|ensembl:ENST00000684462(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|refseq:NP_001153145.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:QuV/ARnvBMJKtiBI0uYmLwBSmqU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P62714	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q99832	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q14498	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-395290|uniprotkb:A5D8W2|uniprotkb:B0BLV3|uniprotkb:Q14499|uniprotkb:A2RRD3|uniprotkb:E1P5S0|uniprotkb:E1P5S1|ensembl:ENSP00000253363	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rbm39_human(display_long)|uniprotkb:HCC1(gene name synonym)|uniprotkb:RBM39(gene name)|psi-mi:RBM39(display_short)|uniprotkb:RNA-binding motif protein 39(gene name synonym)|uniprotkb:RNA-binding region-containing protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma protein 1(gene name synonym)|uniprotkb:Splicing factor HCC1(gene name synonym)|uniprotkb:RNPC2(gene name synonym)|uniprotkb:CAPER alpha(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001229528.1|refseq:NP_001229529.1|refseq:NP_004893.1|refseq:NP_909122.1|ensembl:ENSG00000131051(gene)|ensembl:ENST00000253363(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q14498|rcsb pdb:2JRS|rcsb pdb:2MHN|rcsb pdb:4OO6|rcsb pdb:4OZ0|rcsb pdb:4OZ1|rcsb pdb:4YUD|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|dip:DIP-32928N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:/e7HNZt0CtcDKTwF8BqSwNpyufc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0B4J1R6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955438|ensembl:ENSP00000296289	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0b4j1r6_human(display_long)|uniprotkb:TKT(gene name)|psi-mi:TKT(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000163931(gene)|ensembl:ENST00000296289(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0016740"(transferase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR005474(Transketolase, N-terminal)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR020826|interpro:IPR029061|interpro:IPR033248|refseq:XP_011532357.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:he6m9KlbvFKXGika1Jn9mjtQQ789606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P41091	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1054228|uniprotkb:B5BTZ4|intact:EBI-11602611|uniprotkb:A0A024RBY4|uniprotkb:A8K2Y2|uniprotkb:B2R5N2|uniprotkb:Q53HK3|ensembl:ENSP00000253039	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if2g_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit gamma X(gene name synonym)|uniprotkb:EIF2S3(gene name)|psi-mi:EIF2S3(display_short)|uniprotkb:EIF2G(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001406.1|ensembl:ENSG00000130741(gene)|ensembl:ENST00000253039(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR044127|interpro:IPR044128|rcsb pdb:6FEC|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|interpro:IPR027417	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:6uBTiGTvEKMfS0NqkKGIaSR61j89606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W726	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955080|ensembl:ENSP00000271877	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w726_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143569(gene)|ensembl:ENST00000271877(transcript)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001317659.1|refseq:XP_016858474.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ubziKKFRBd1iMzyzCDu/sNF1+T09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BRU6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25624190|ensembl:ENSP00000456412	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3bru6_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000197111(gene)|ensembl:ENST00000562264(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:xb53MM1DpOlNu8kGWwnn4uvAlsU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9NP64	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-746345|uniprotkb:Q6PKH4|uniprotkb:Q9NYG4|uniprotkb:Q9P0M8|uniprotkb:D3DPN4|ensembl:ENSP00000343557|ensembl:ENSP00000362819|uniprotkb:B4DY38	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:no40_human(display_long)|uniprotkb:Zinc finger CCHC domain-containing protein 17(gene name synonym)|uniprotkb:Putative S1 RNA-binding domain protein(gene name synonym)|uniprotkb:Pnn-interacting nucleolar protein(gene name synonym)|uniprotkb:ZCCHC17(gene name)|psi-mi:ZCCHC17(display_short)|uniprotkb:HSPC243(orf name)|uniprotkb:HSPC251(orf name)|uniprotkb:LDC4(orf name)|uniprotkb:PS1D(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001269495.1|refseq:NP_001269496.1|refseq:NP_001269497.1|refseq:NP_001269498.1|refseq:NP_001269499.1|refseq:NP_001269500.1|refseq:NP_001269501.1|refseq:NP_001269502.1|refseq:NP_001269503.1|refseq:XP_006710744.1|refseq:NP_057589.2|refseq:XP_011539869.1|ensembl:ENSG00000121766(gene)|ensembl:ENST00000344147(transcript)|ensembl:ENST00000373714(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR003029(S1, RNA binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR037320|mint:Q9NP64|rcsb pdb:2CQO	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:e71wAulRWX6cM59s3g8R42PWXeU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:D6RE83	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955419|ensembl:ENSP00000426895	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:d6re83_human(display_long)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000154277(gene)|ensembl:ENST00000508768(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:6L84eFlSsU0gjYXVZj+vsdC9KNA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A1B0GVS3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955409|ensembl:ENSP00000490634	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a1b0gvs3_human(display_long)|uniprotkb:ACTR1A(gene name)|psi-mi:ACTR1A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000138107(gene)|ensembl:ENST00000636707(transcript)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:sLsW1w9CehUwJxFgxO3zaOsIpwY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087X1Q1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955387|ensembl:ENSP00000484375	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087x1q1_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000141510(gene)|ensembl:ENST00000619186(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR036674|refseq:NP_001263626.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lFEv0M7hPmWu+BqnkUduW+UsLsg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UBF2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1045840|uniprotkb:A6NH74|uniprotkb:Q54AC3|uniprotkb:Q8WVW8|ensembl:ENSP00000402346|uniprotkb:Q2NLA0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:copg2_human(display_long)|uniprotkb:Gamma-2-coat protein(gene name synonym)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001276962.1|refseq:NP_036265.3|ensembl:ENSG00000158623(gene)|ensembl:ENST00000425248(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9UBF2|reactome:R-HSA-6807878|reactome:R-HSA-6811434|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VEvct8z8lwNWbLs2GFPrKwk1GpE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8N3C0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1AKQ8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-6190833|ensembl:ENSP00000416651	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1akq8_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000078369(gene)|ensembl:ENST00000437146(transcript)|go:"GO:0007165"(signal transduction)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR036322	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:BUB/7mf+WlDyk4rDXHXUrW9rKWE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0A0MR02	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955371|ensembl:ENSP00000298468	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0a0mr02_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Voltage-dependent anion-selective channel protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000165637(gene)|ensembl:ENST00000298468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0046930"(pore complex)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8HWHyvR2+i897d+4nimDc65Z/DM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q14152	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06576	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q15181	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-712298|ensembl:ENSP00000362329|uniprotkb:Q2M348|uniprotkb:Q5SQT7|uniprotkb:Q6P7P4|uniprotkb:Q9UQJ5|uniprotkb:Q9Y5B1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ipyr_human(display_long)|uniprotkb:Pyrophosphate phospho-hydrolase(gene name synonym)|uniprotkb:PPA1(gene name)|psi-mi:PPA1(display_short)|uniprotkb:IOPPP(gene name synonym)|uniprotkb:PP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000180817(gene)|ensembl:ENST00000373232(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004427"(inorganic diphosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008162(Inorganic pyrophosphatase)|interpro:IPR036649|mint:Q15181|rcsb pdb:6C45|rcsb pdb:7BTN|rcsb pdb:7CMO|reactome:R-HSA-379716|reactome:R-HSA-71737|refseq:NP_066952.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1094gn9aeisgfDUhIroRn2iqom49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYK2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11110166|ensembl:ENSP00000440901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyk2_human(display_long)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090372(gene)|ensembl:ENST00000539396(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CWwVsvNBEouYub9DRx3ykuw6Wqg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q15185	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y265	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BUF6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955067|ensembl:ENSP00000457613	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3buf6_human(display_long)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000564304(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|refseq:NP_001295159.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:deregvuN/2hveFXyezm8WFOtXqs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07737	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P62995	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-725485|uniprotkb:O15449|uniprotkb:Q15815|uniprotkb:Q64283|uniprotkb:B4DVK2|uniprotkb:D3DNU3|ensembl:ENSP00000416959	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tra2b_human(display_long)|uniprotkb:TRA2B(gene name)|psi-mi:TRA2B(display_short)|uniprotkb:SFRS10(gene name synonym)|uniprotkb:Transformer-2 protein homolog B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 10(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004584.1|refseq:XP_005247760.1|refseq:NP_001230808.1|refseq:XP_011511374.1|ensembl:ENSG00000136527(gene)|ensembl:ENST00000453386(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P62995|rcsb pdb:2CQC|rcsb pdb:2KXN|rcsb pdb:2RRA|rcsb pdb:2RRB|reactome:R-HSA-72163|reactome:R-HSA-9013418|reactome:R-HSA-9013422|refseq:XP_016862522.1|dip:DIP-42278N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:6uZGeHEDlIVsb2uPeo+9NoR4tDw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P26641	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087X0X3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-21358796|ensembl:ENSP00000483715	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087x0x3_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000099783(gene)|ensembl:ENST00000620401(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7Ziuss290fVTc0Si7slqasNq0As9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BY89	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-8796741|intact:EBI-28980779|ensembl:ENSP00000351207|ensembl:ENSP00000385152|uniprotkb:B7ZW08|uniprotkb:Q5THZ5|uniprotkb:B0QYF2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:k1671_human(display_long)|uniprotkb:KIAA1671(gene name)|psi-mi:KIAA1671(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000197077(gene)|ensembl:ENST00000358431(transcript)|ensembl:ENST00000406486(transcript)|interpro:IPR032764|interpro:IPR040006|ensembl:ENSP00000351207|ensembl:ENST00000401395|ensembl:ENSP00000385377|ensembl:ENSP00000385152|refseq:XP_005261850.1|refseq:XP_005261851.1|refseq:NP_001138678.1|refseq:XP_006724409.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7mCSVXo/8Z2MUHqsxKKXrBvOe749606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PKG1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955360|ensembl:ENSP00000433556	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9pkg1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000126457(gene)|ensembl:ENST00000532489(transcript)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iHRBppkBRG2hwgFZWEP1p/bKi+A9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O43432	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9NR30	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357942|uniprotkb:Q13436|uniprotkb:Q5VX41|uniprotkb:Q68D35|uniprotkb:B2RDL0|intact:EBI-2555822|ensembl:ENSP00000346120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ddx21_human(display_long)|uniprotkb:DDX21(gene name)|psi-mi:DDX21(display_short)|uniprotkb:Nucleolar RNA helicase II(gene name synonym)|uniprotkb:Nucleolar RNA helicase Gu(gene name synonym)|uniprotkb:RH II/Gu(gene name synonym)|uniprotkb:Gu-alpha(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004719.2|dip:DIP-32941N|refseq:NP_001243839.1|ensembl:ENSG00000165732(gene)|ensembl:ENST00000354185(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0030515"(snoRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012562(GUCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR035979|mint:Q9NR30|rcsb pdb:2M3D|rcsb pdb:6L5L|rcsb pdb:6L5M|rcsb pdb:6L5N|rcsb pdb:6L5O|reactome:R-HSA-5250924|reactome:R-HSA-6791226|go:"GO:0005829"(cytosol)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:NSmxvs3DBWvKpVDEAHIpqy7/b6w9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:M0QXS5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11897460|ensembl:ENSP00000469349	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:m0qxs5_human(display_long)|uniprotkb:HNRNPL(gene name)|psi-mi:HNRNPL(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000104824(gene)|ensembl:ENST00000601449(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:tMnqE8suzol5lFcvM9Vp1pf63DI9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P35579	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P24534	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354334|uniprotkb:Q6IBH9|uniprotkb:A8K795|ensembl:ENSP00000236957|ensembl:ENSP00000376055|ensembl:ENSP00000376056|ensembl:ENSP00000489993|ensembl:ENSP00000490214|ensembl:ENSP00000490326	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ef1b_human(display_long)|uniprotkb:EEF1B(gene name synonym)|uniprotkb:EF1B(gene name synonym)|uniprotkb:EEF1B2(gene name)|psi-mi:EEF1B2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001032752.1|refseq:NP_001950.1|refseq:NP_066944.1|ensembl:ENSG00000114942(gene)|ensembl:ENSG00000283391(gene)|ensembl:ENST00000236957(transcript)|ensembl:ENST00000392221(transcript)|ensembl:ENST00000392222(transcript)|ensembl:ENST00000635728(transcript)|ensembl:ENST00000636275(transcript)|ensembl:ENST00000637253(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045471"(response to ethanol)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219|interpro:IPR036282|mint:P24534|rcsb pdb:1B64|rcsb pdb:5DQS|reactome:R-HSA-156842	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:d4zkwQOMlpr6XBapMfT1sxy2ZPs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P00338	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06744	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558394|uniprotkb:Q9UHE6|uniprotkb:Q9BSK5|uniprotkb:Q9BRD3|ensembl:ENSP00000348877|uniprotkb:B4DG39	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g6pi_human(display_long)|uniprotkb:GPI(gene name)|psi-mi:GPI(display_short)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)|uniprotkb:Autocrine motility factor(gene name synonym)|uniprotkb:Neuroleukin(gene name synonym)|uniprotkb:Sperm antigen 36(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000166.2|ensembl:ENSG00000105220(gene)|ensembl:ENST00000356487(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007599"(hemostasis)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:1IAT|rcsb pdb:1IRI|rcsb pdb:1JIQ|rcsb pdb:1JLH|rcsb pdb:1NUH|rcsb pdb:6XUH|rcsb pdb:6XUI|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-5628897|refseq:NP_001171651.1|refseq:NP_001316838.1|refseq:NP_001316839.1|refseq:NP_001316840.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:R3ftNtHikgoVdqLjC4d6I5lpENU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P22087	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P51991	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1050760|uniprotkb:Q53RW7|uniprotkb:Q6URK5|uniprotkb:D3DPF4|ensembl:ENSP00000376309|ensembl:ENSP00000416340|ensembl:ENSP00000503593|ensembl:ENSP00000504135|ensembl:ENSP00000504152	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:roa3_human(display_long)|uniprotkb:HNRPA3(gene name synonym)|uniprotkb:HNRNPA3(gene name)|psi-mi:HNRNPA3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_919223.1|refseq:NP_001317178.1|ensembl:ENSG00000170144(gene)|ensembl:ENST00000392524(transcript)|ensembl:ENST00000435711(transcript)|ensembl:ENST00000676629(transcript)|ensembl:ENST00000678111(transcript)|ensembl:ENST00000679159(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0051028"(mRNA transport)|go:"GO:0051033"(RNA transmembrane transporter activity)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034513|interpro:IPR034516|interpro:IPR035979|mint:P51991|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:bbg0nIdhEHomcwtgZhT2yHy7+nU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q15233	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13151	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-724092|ensembl:ENSP00000316042|intact:EBI-1043661|uniprotkb:Q6IB18	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:roa0_human(display_long)|uniprotkb:HNRPA0(gene name synonym)|uniprotkb:HNRNPA0(gene name)|psi-mi:HNRNPA0(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006796.1|ensembl:ENSG00000177733(gene)|ensembl:ENST00000314940(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034801|interpro:IPR035979|mint:Q13151|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:buyQxR8FLxd4N6jRhwVsroeGrBw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q16658	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351076|uniprotkb:Q96IH1|uniprotkb:A6NI89|uniprotkb:Q96IC5|uniprotkb:Q9BRF1|uniprotkb:B2RE97|ensembl:ENSP00000371798	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:fscn1_human(display_long)|uniprotkb:FSCN1(gene name)|psi-mi:FSCN1(display_short)|uniprotkb:FAN1(gene name synonym)|uniprotkb:HSN(gene name synonym)|uniprotkb:SNL(gene name synonym)|uniprotkb:Singed-like protein(gene name synonym)|uniprotkb:55 kDa actin-bundling protein(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031253"(cell projection membrane)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0044393"(microspike)|go:"GO:0045296"(cadherin binding)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR008999(Actin_cross-linking)|interpro:IPR010431(Fascin)|interpro:IPR022768|interpro:IPR024703|interpro:IPR030146|mint:Q16658|rcsb pdb:1DFC|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030035"(microspike assembly)|rcsb pdb:3LLP|refseq:NP_003079.1|ensembl:ENSG00000075618(gene)|ensembl:ENST00000382361(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008144"(obsolete drug binding)|rcsb pdb:3P53|rcsb pdb:4GOV|rcsb pdb:4GOY|rcsb pdb:4GP3|rcsb pdb:6B0T|rcsb pdb:6I0Z|rcsb pdb:6I10|rcsb pdb:6I11|rcsb pdb:6I12|rcsb pdb:6I13|rcsb pdb:6I14|rcsb pdb:6I15|rcsb pdb:6I16|rcsb pdb:6I17|rcsb pdb:6I18|reactome:R-HSA-6785807|rcsb pdb:4GP0|dip:DIP-33171N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:yc9EJDCKGJGGEcEueR/yAY/fxRg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P05141	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355133|uniprotkb:O43350|uniprotkb:B2RCV1|ensembl:ENSP00000360671	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:adt2_human(display_long)|uniprotkb:SLC25A5(gene name)|psi-mi:SLC25A5(display_short)|uniprotkb:ANT2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:ADP,ATP carrier protein, fibroblast isoform(gene name synonym)|uniprotkb:AAC2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001143.2|reactome:R-HSA-83936|reactome:R-HSA-180897|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015207"(adenine transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P05141|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000005022(gene)|ensembl:ENST00000317881(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|dip:DIP-33873N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8b4IQKtL2FJG/MS/5+mJUJrggYc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P67809	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y277	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75534	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-719186|uniprotkb:O94961|uniprotkb:Q5TF04|uniprotkb:Q5TF05|uniprotkb:Q68DI9|uniprotkb:Q9Y2S4|uniprotkb:E9PGZ0|uniprotkb:Q68DF1|intact:EBI-1059183|ensembl:ENSP00000351329|ensembl:ENSP00000432958|uniprotkb:A8K281|uniprotkb:G5E9Q2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:csde1_human(display_long)|uniprotkb:Protein UNR(gene name synonym)|uniprotkb:N-ras upstream gene protein(gene name synonym)|uniprotkb:CSDE1(gene name)|psi-mi:CSDE1(display_short)|uniprotkb:D1S155E(gene name synonym)|uniprotkb:KIAA0885(gene name synonym)|uniprotkb:NRU(gene name synonym)|uniprotkb:UNR(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001007554.1|refseq:NP_001123995.1|refseq:NP_001229820.1|refseq:NP_001229821.1|refseq:NP_001229822.1|refseq:NP_009089.4|ensembl:ENSG00000009307(gene)|ensembl:ENST00000358528(transcript)|ensembl:ENST00000534699(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008584"(male gonad development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR019844|interpro:IPR024642|mint:O75534|rcsb pdb:1WFQ|rcsb pdb:1X65|rcsb pdb:2YTV|rcsb pdb:2YTX|rcsb pdb:2YTY|interpro:IPR012340(Nucleic acid-binding, OB-fold)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:fpL1bONjNXyXjIO/akUIIoeEGTc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O43143	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P12236	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356254|ensembl:ENSP00000370808|uniprotkb:Q96C49	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:adt3_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ANT3(gene name synonym)|uniprotkb:CDABP0051(orf name)|uniprotkb:Adenine nucleotide translocator 3(gene name synonym)|uniprotkb:ADP,ATP carrier protein 3(gene name synonym)|uniprotkb:Solute carrier family 25 member 6(gene name synonym)|uniprotkb:ADP,ATP carrier protein, isoform T2(gene name synonym)|uniprotkb:AAC3(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000169100(gene)|ensembl:ENST00000381401(transcript)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P12236|reactome:R-HSA-1268020|reactome:R-HSA-168277|reactome:R-HSA-180897|reactome:R-HSA-83936|refseq:NP_001627.2	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EQB2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11024579|ensembl:ENSP00000397427	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7eqb2_human(display_long)|uniprotkb:LTF(gene name)|psi-mi:LTF(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000012223(gene)|ensembl:ENST00000443496(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030684	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dRvzWJ7CBygbgGScODXEIV8+5xg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9NZC7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P23246	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96GA3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558389|uniprotkb:Q96JX8|ensembl:ENSP00000356548	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ltv1_human(display_long)|uniprotkb:LTV1(gene name)|psi-mi:LTV1(display_short)|uniprotkb:C6orf93(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116249.2|ensembl:ENSG00000135521(gene)|ensembl:ENST00000367576(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007307(Low temperature viability protein)|mint:Q96GA3|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|reactome:R-HSA-6791226	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Csfx8GS5hoclLY1BYki/uUKoSIM9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B0QYA5	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955350|ensembl:ENSP00000390438	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b0qya5_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000100353(gene)|ensembl:ENST00000455547(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:NqzGC8S1EiJlh3PBXyRqZwMBpGs9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13247	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-745230|uniprotkb:Q13244|uniprotkb:Q13245|uniprotkb:Q96J06|uniprotkb:Q9UJB8|uniprotkb:Q9Y3N7|uniprotkb:B7Z6J3|uniprotkb:E1P5W6|ensembl:ENSP00000244020	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:srsf6_human(display_long)|uniprotkb:Pre-mRNA-splicing factor SRP55(gene name synonym)|uniprotkb:SRSF6(gene name)|psi-mi:SRSF6(display_short)|uniprotkb:SRP55(gene name synonym)|uniprotkb:SFRS6(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 6(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006266.2|ensembl:ENSG00000124193(gene)|ensembl:ENST00000244020(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0032868"(response to insulin)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061041"(regulation of wound healing)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029541|interpro:IPR034511|interpro:IPR035979|mint:Q13247|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:vU4nobP3g/hsgnll0mQgjJcME2k9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SEM4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955335|ensembl:ENSP00000485813	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sem4_human(display_long)|uniprotkb:SRSF4(gene name)|psi-mi:SRSF4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000116350(gene)|ensembl:ENST00000466448(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035585|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:DYNrxUvaD4gUuBMTXIInVJCjYwk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087X2D0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955324|ensembl:ENSP00000484891	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087x2d0_human(display_long)|uniprotkb:SRSF3(gene name)|psi-mi:SRSF3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000112081(gene)|ensembl:ENST00000613941(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:W53LTQp3JilExJK4eFrEctPuR7c9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P23526	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P62937	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-437708|uniprotkb:P05092|uniprotkb:Q3KQW3|uniprotkb:Q6IBU5|uniprotkb:Q96IX3|uniprotkb:Q9BRU4|uniprotkb:Q9BTY9|uniprotkb:Q9UC61|uniprotkb:Q567Q0|ensembl:ENSP00000419425|uniprotkb:A8K220	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ppia_human(display_long)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:PPIA(gene name)|psi-mi:PPIA(display_short)|uniprotkb:CYPA(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_066953.1|interpro:IPR029000|mint:P62937|rcsb pdb:1AK4|rcsb pdb:1AWQ|rcsb pdb:1AWR|rcsb pdb:1AWS|rcsb pdb:1AWT|rcsb pdb:1AWU|rcsb pdb:1AWV|rcsb pdb:1BCK|rcsb pdb:1CWA|rcsb pdb:1CWB|rcsb pdb:1CWC|rcsb pdb:1CWF|rcsb pdb:1CWH|rcsb pdb:1CWI|rcsb pdb:1CWJ|rcsb pdb:1CWK|rcsb pdb:1CWL|rcsb pdb:1CWM|interpro:IPR024936|rcsb pdb:1CWO|rcsb pdb:1FGL|rcsb pdb:2N0T|rcsb pdb:2RMA|rcsb pdb:1M63|rcsb pdb:2RMB|rcsb pdb:2X25|rcsb pdb:2X2A|rcsb pdb:2X2C|rcsb pdb:2X2D|rcsb pdb:1M9C|rcsb pdb:1M9D|rcsb pdb:1M9E|rcsb pdb:2XGY|rcsb pdb:3CYH|rcsb pdb:3CYS|rcsb pdb:3K0M|rcsb pdb:3K0N|rcsb pdb:3K0O|rcsb pdb:3K0P|rcsb pdb:3K0Q|rcsb pdb:3K0R|rcsb pdb:3ODI|rcsb pdb:3ODL|rcsb pdb:1M9F|rcsb pdb:3RDD|rcsb pdb:1M9X|rcsb pdb:1M9Y|rcsb pdb:4CYH|rcsb pdb:4IPZ|rcsb pdb:4N1M|rcsb pdb:4N1N|rcsb pdb:1MF8|rcsb pdb:4N1O|rcsb pdb:4N1P|rcsb pdb:4N1Q|rcsb pdb:1MIK|rcsb pdb:1NMK|rcsb pdb:1OCA|rcsb pdb:1RMH|rcsb pdb:1VBS|rcsb pdb:1VBT|rcsb pdb:1W8L|rcsb pdb:1W8M|rcsb pdb:1W8V|rcsb pdb:1YND|rcsb pdb:1ZKF|rcsb pdb:2ALF|rcsb pdb:2CPL|rcsb pdb:2CYH|rcsb pdb:2MS4|rcsb pdb:2MZU|rcsb pdb:4N1R|rcsb pdb:4N1S|rcsb pdb:4YUG|rcsb pdb:4YUH|refseq:NP_001287910.1|reactome:R-HSA-210991|reactome:R-HSA-6798695|reactome:R-HSA-8950505|reactome:R-HSA-2025928|ensembl:ENSG00000196262(gene)|ensembl:ENST00000468812(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031982"(vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046790"(virion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|go:"GO:0005178"(integrin binding)|rcsb pdb:4YUI|rcsb pdb:4YUJ|rcsb pdb:4YUK|rcsb pdb:4YUL|rcsb pdb:4YUM|rcsb pdb:4YUN|rcsb pdb:4YUO|rcsb pdb:4YUP|rcsb pdb:5CYH|rcsb pdb:5F66|rcsb pdb:5FJB|rcsb pdb:5KUL|rcsb pdb:5KUN|rcsb pdb:5KUO|rcsb pdb:5KUQ|rcsb pdb:5KUR|rcsb pdb:5KUS|rcsb pdb:5KUU|rcsb pdb:5KUV|rcsb pdb:5KUW|rcsb pdb:5KUZ|rcsb pdb:5KV0|rcsb pdb:5KV1|rcsb pdb:5KV2|rcsb pdb:5KV3|rcsb pdb:5KV4|rcsb pdb:5KV5|rcsb pdb:5KV6|rcsb pdb:5KV7|rcsb pdb:5LUD|rcsb pdb:5NOQ|rcsb pdb:5NOR|rcsb pdb:5NOT|rcsb pdb:5NOU|rcsb pdb:5NOV|rcsb pdb:5NOW|rcsb pdb:5NOX|rcsb pdb:5NOY|rcsb pdb:5NOZ|rcsb pdb:5T9U|rcsb pdb:5T9W|rcsb pdb:5T9Z|rcsb pdb:5TA2|rcsb pdb:5TA4|rcsb pdb:5WC7|rcsb pdb:6BTA|rcsb pdb:6GJI|rcsb pdb:6GJJ|rcsb pdb:6GJL|rcsb pdb:6GJM|rcsb pdb:6GJN|rcsb pdb:6GJP|rcsb pdb:6GJR|rcsb pdb:6GJY|rcsb pdb:6GS6|rcsb pdb:6I42|rcsb pdb:6U5C|rcsb pdb:6U5D|rcsb pdb:6U5E|rcsb pdb:6U5G|rcsb pdb:6X3R|rcsb pdb:6X3Y|rcsb pdb:5NOS|rcsb pdb:6X4N|rcsb pdb:6X4O|rcsb pdb:6X4P|rcsb pdb:6X4Q|rcsb pdb:6Y9V|rcsb pdb:6Y9W|rcsb pdb:6Y9X|rcsb pdb:6Y9Y|rcsb pdb:6Y9Z|rcsb pdb:6ZDJ|rcsb pdb:7ABT|reactome:R-HSA-114608|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-173107|rcsb pdb:6X4M|reactome:R-HSA-175474|reactome:R-HSA-180689|dip:DIP-6080N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dr4EVxcO+sqTPBqsQcydRn+rHoo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:D6REB4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955312|ensembl:ENSP00000425084	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:d6reb4_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000172239(gene)|ensembl:ENST00000514514(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VGsNpIHUK+ki2Z1/IAYcYD6DsPk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95905	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2557598|ensembl:ENSP00000362070|uniprotkb:C9JX46|uniprotkb:E9PAW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ecd_human(display_long)|uniprotkb:Human suppressor of GCR two(gene name synonym)|uniprotkb:ECD(gene name)|psi-mi:ECD(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129225.1|refseq:NP_009196.1|ensembl:ENSG00000122882(gene)|ensembl:ENST00000372979(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR010770(SGT1)|refseq:NP_001129224.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7uvREpWu7KW0cAo8zcf7SSkaQiY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EX73	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955017|ensembl:ENSP00000399858	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7ex73_human(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000114867(gene)|ensembl:ENST00000441154(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1qdHA6IrcrYFYKmrDfOt8zNV/W49606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P43243	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BPS8	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955300|ensembl:ENSP00000455455	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3bps8_human(display_long)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000149925(gene)|ensembl:ENST00000562679(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:s8x5TAZeQXSgxS4tFSaOAl6kDtI9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P09874	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SFB3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955049|ensembl:ENSP00000486443	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sfb3_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215301(gene)|ensembl:ENST00000626301(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016787"(hydrolase activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3HBCl/lJwdnqa4IyzA2ToiWUcJw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9HB71	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75152	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-748480|uniprotkb:Q6AHY4|uniprotkb:Q6AHY9|uniprotkb:Q6AW79|uniprotkb:Q6AWA1|uniprotkb:Q6PJK4|uniprotkb:Q86XZ7|ensembl:ENSP00000333253|ensembl:ENSP00000356179|ensembl:ENSP00000356181|ensembl:ENSP00000356183|ensembl:ENSP00000491830	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:zc11a_human(display_long)|uniprotkb:ZC3H11A(gene name)|psi-mi:ZC3H11A(display_short)|uniprotkb:KIAA0663(gene name synonym)|uniprotkb:ZC3HDC11A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006711736.1|refseq:NP_055642.3|refseq:XP_011508501.1|refseq:XP_011508502.1|refseq:XP_011508503.1|refseq:XP_011508504.1|refseq:NP_001306167.1|refseq:NP_001306168.1|refseq:XP_005245700.1|refseq:XP_005245701.1|refseq:XP_016858445.1|refseq:XP_016858446.1|refseq:XP_016858447.1|refseq:XP_016858448.1|ensembl:ENSG00000058673(gene)|ensembl:ENST00000332127(transcript)|ensembl:ENST00000367210(transcript)|ensembl:ENST00000367212(transcript)|ensembl:ENST00000367214(transcript)|ensembl:ENST00000639812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR041686|mint:O75152|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:BJfX/K7kBXQGQx6l+Y2xBtwyJAw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P14625	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q5SW79	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q08211	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352022|intact:EBI-1058470|uniprotkb:Q5VY62|uniprotkb:Q6PD69|uniprotkb:Q99556|uniprotkb:B2RNV4|uniprotkb:Q05CI5|uniprotkb:Q12803|uniprotkb:Q32Q22|ensembl:ENSP00000356520	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:dhx9_human(display_long)|uniprotkb:DHX9(gene name)|psi-mi:DHX9(display_short)|uniprotkb:DDX9(gene name synonym)|uniprotkb:NDH2(gene name synonym)|uniprotkb:DExH-box helicase 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:LKP(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Leukophysin(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001348.2|dip:DIP-31504N|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|mint:Q08211|rcsb pdb:3LLM|rcsb pdb:3VYX|rcsb pdb:3VYY|reactome:R-HSA-1810476|reactome:R-HSA-3134963|reactome:R-HSA-72163|go:"GO:1904973"(positive regulation of viral translation)|ensembl:ENSG00000135829(gene)|ensembl:ENST00000367549(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006260"(DNA replication)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:b0VP2Frtvwa9WbYVMwB6TbV2uGU9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92841	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P25705	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PCY7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955284|ensembl:ENSP00000426275	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9pcy7_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000169045(gene)|ensembl:ENST00000510411(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|refseq:XP_006714926.1|refseq:XP_016864908.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ZMh0JvpYCI4NPTIESnY6nYZneEk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P12277	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357706|uniprotkb:Q2LE07|uniprotkb:A8K236|uniprotkb:B2R5R4|uniprotkb:Q6FG40|uniprotkb:Q9UC66|ensembl:ENSP00000299198	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kcrb_human(display_long)|uniprotkb:CKB(gene name)|psi-mi:CKB(display_short)|uniprotkb:CKBB(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:Brain creatine kinase(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001814.2|go:"GO:0005829"(cytosol)|ensembl:ENSG00000166165(gene)|ensembl:ENST00000348956(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12277|rcsb pdb:3B6R|rcsb pdb:3DRB|rcsb pdb:3DRE|rcsb pdb:6V9H|go:"GO:0021762"(substantia nigra development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046314"(phosphocreatine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-71288|reactome:R-HSA-9696264|dip:DIP-52968N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WLRnU8sRUfJQoaPY0edGi9xiR+g9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:J3KTA4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-21359408|ensembl:ENSP00000462885	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:j3kta4_human(display_long)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:Probable ATP-dependent RNA helicase DDX5(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000108654(gene)|ensembl:ENST00000578804(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0048511"(rhythmic process)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_001307526.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3WQZTzoJ+tGsIUs8m+5gywxMQ8o9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P13639	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P32119	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P52597	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1ANR0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-9977484|ensembl:ENSP00000361953	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P61978	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P62826	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-286642|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q6IPB2|uniprotkb:Q86V08|uniprotkb:Q8NI90|uniprotkb:Q9CZA2|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9UDJ5|uniprotkb:Q9UEU9|uniprotkb:A8K3Z8|ensembl:ENSP00000376176|ensembl:ENSP00000446215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ran_human(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Androgen receptor-associated protein 24(gene name synonym)|uniprotkb:RAN(gene name)|psi-mi:RAN(display_short)|uniprotkb:ARA24(gene name synonym)|uniprotkb:OK/SW-cl.81(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006316.1|refseq:NP_001287725.1|refseq:NP_001287726.1|dip:DIP-5929N|ensembl:ENSG00000132341(gene)|ensembl:ENST00000392369(transcript)|ensembl:ENST00000543796(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0016020"(membrane)|go:"GO:0016032"(viral process)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62826|rcsb pdb:1I2M|rcsb pdb:1IBR|rcsb pdb:1K5D|rcsb pdb:1K5G|rcsb pdb:1QBK|rcsb pdb:1RRP|rcsb pdb:2MMC|rcsb pdb:2MMG|rcsb pdb:2N1B|rcsb pdb:3CH5|rcsb pdb:3EA5|rcsb pdb:3GJ0|rcsb pdb:3GJ3|rcsb pdb:3GJ4|rcsb pdb:3GJ5|rcsb pdb:3GJ6|rcsb pdb:3GJ7|rcsb pdb:3GJ8|rcsb pdb:3GJX|rcsb pdb:3NBY|rcsb pdb:3NBZ|rcsb pdb:3NC0|rcsb pdb:3NC1|rcsb pdb:3ZJY|rcsb pdb:4C0Q|rcsb pdb:4GMX|rcsb pdb:4GPT|rcsb pdb:4HAT|rcsb pdb:4HAU|rcsb pdb:4HAV|rcsb pdb:4HAW|rcsb pdb:4HAX|rcsb pdb:4HAY|rcsb pdb:4HAZ|rcsb pdb:4HB0|rcsb pdb:4HB2|rcsb pdb:4HB3|rcsb pdb:4HB4|rcsb pdb:4OL0|rcsb pdb:4WVF|rcsb pdb:5CIQ|rcsb pdb:5CIT|rcsb pdb:5CIW|rcsb pdb:5CJ2|rcsb pdb:5CLL|rcsb pdb:5CLQ|rcsb pdb:5DH9|rcsb pdb:5DHA|rcsb pdb:5DHF|rcsb pdb:5DI9|rcsb pdb:5DIF|rcsb pdb:5DIS|rcsb pdb:5DLQ|rcsb pdb:5FYQ|rcsb pdb:5JLJ|rcsb pdb:5UWH|rcsb pdb:5UWI|rcsb pdb:5UWJ|rcsb pdb:5UWO|rcsb pdb:5UWP|rcsb pdb:5UWQ|rcsb pdb:5UWR|rcsb pdb:5UWS|rcsb pdb:5UWT|rcsb pdb:5UWU|rcsb pdb:5UWW|rcsb pdb:5YRO|rcsb pdb:5YST|rcsb pdb:5YSU|rcsb pdb:5YTB|rcsb pdb:5ZPU|rcsb pdb:6A38|rcsb pdb:6A3A|rcsb pdb:6A3B|rcsb pdb:6A3C|rcsb pdb:6A3E|rcsb pdb:6CIT|rcsb pdb:6KFT|rcsb pdb:6LQ9|rcsb pdb:6M60|rcsb pdb:6M6X|rcsb pdb:6Q82|rcsb pdb:6Q84|rcsb pdb:6TVO|rcsb pdb:6X2M|rcsb pdb:6X2O|rcsb pdb:6X2P|rcsb pdb:6X2R|rcsb pdb:6X2S|rcsb pdb:6X2U|rcsb pdb:6X2V|rcsb pdb:6X2W|rcsb pdb:6X2X|rcsb pdb:6X2Y|rcsb pdb:6XJP|rcsb pdb:6XJR|rcsb pdb:6XJS|rcsb pdb:6XJT|rcsb pdb:6XJU|rcsb pdb:7B51|rcsb pdb:7CND|rcsb pdb:7L5E|reactome:R-HSA-165054|reactome:R-HSA-1655829|reactome:R-HSA-168333|reactome:R-HSA-180746|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-6784531|reactome:R-HSA-9615933	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0A0MSI0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-25629339|ensembl:ENSP00000389047|ensembl:ENSP00000407034	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0a0msi0_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000117450(gene)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR024706|interpro:IPR036249	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:k0Uz2Vfkot84A/EMR3NJTktXdnk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P52732	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355697|uniprotkb:A0AV49|uniprotkb:Q15716|uniprotkb:Q5VWX0|uniprotkb:B2RMV3|ensembl:ENSP00000260731	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kif11_human(display_long)|uniprotkb:KIF11(gene name)|psi-mi:KIF11(display_short)|uniprotkb:EG5(gene name synonym)|uniprotkb:KNSL1(gene name synonym)|uniprotkb:TRIP5(gene name synonym)|uniprotkb:Kinesin-related motor protein Eg5(gene name synonym)|uniprotkb:Kinesin-like spindle protein HKSP(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 5(gene name synonym)|uniprotkb:Kinesin-like protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004514.2|ensembl:ENSG00000138160(gene)|ensembl:ENST00000260731(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|rcsb pdb:1X88|rcsb pdb:1YRS|rcsb pdb:2FKY|rcsb pdb:2FL2|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR025901|interpro:IPR027417|interpro:IPR036961|rcsb pdb:1II6|rcsb pdb:1Q0B|rcsb pdb:2FL6|rcsb pdb:2FME|rcsb pdb:2G1Q|rcsb pdb:2GM1|rcsb pdb:2IEH|rcsb pdb:2PG2|rcsb pdb:2Q2Y|rcsb pdb:2Q2Z|rcsb pdb:2UYI|rcsb pdb:2UYM|rcsb pdb:2WOG|rcsb pdb:2X2R|rcsb pdb:2X7C|rcsb pdb:2X7D|rcsb pdb:2X7E|rcsb pdb:2XAE|rcsb pdb:3CJO|rcsb pdb:3HQD|rcsb pdb:3K3B|rcsb pdb:3K5E|rcsb pdb:3KEN|rcsb pdb:3L9H|rcsb pdb:3WPN|rcsb pdb:3ZCW|rcsb pdb:4A1Z|rcsb pdb:4A28|rcsb pdb:4A50|rcsb pdb:4A51|rcsb pdb:4A5Y|rcsb pdb:4AP0|rcsb pdb:4AQV|rcsb pdb:4AQW|rcsb pdb:4AS7|rcsb pdb:4B7B|rcsb pdb:4BBG|rcsb pdb:4BXN|rcsb pdb:4CK5|rcsb pdb:4CK6|rcsb pdb:4CK7|rcsb pdb:4ZCA|rcsb pdb:4ZHI|rcsb pdb:5JV3|rcsb pdb:5ZO7|rcsb pdb:5ZO8|rcsb pdb:5ZO9|rcsb pdb:6G6Y|rcsb pdb:6G6Z|rcsb pdb:6HKX|rcsb pdb:6HKY|rcsb pdb:6TA3|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6TLE|rcsb pdb:6TRL|rcsb pdb:6Y1I|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-53686N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YimbfuWYTSuyqgfs2RF8kCx2+xE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P22626	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P17066	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WTT1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955001|ensembl:ENSP00000478108	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wtt1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000070756(gene)|ensembl:ENST00000610907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|interpro:IPR000504(RNA recognition motif, RNP-1)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cK4lGsqOggjFbeqhmhHwrjWSECA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P63244	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P60842	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W6I7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955265|ensembl:ENSP00000333504	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w6i7_human(display_long)|uniprotkb:HNRNPA1(gene name)|psi-mi:HNRNPA1(display_short)|uniprotkb:Heterogeneous nuclear ribonucleoprotein A1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000135486(gene)|ensembl:ENST00000330752(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:B8tSRkVcOCrRN4rWXszZZvujGlo9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y2Z0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:C9JKR2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955250|ensembl:ENSP00000401820	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c9jkr2_human(display_long)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:hCG_14967(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000163631(gene)|ensembl:ENST00000415165(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|go:"GO:0005783"(endoplasmic reticulum)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nhBmKei2NpXW4JoyT6Ks86brhFQ9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P0CG39	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-6151401|ensembl:ENSP00000387176	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:potej_human(display_long)|uniprotkb:POTEJ(gene name)|psi-mi:POTEJ(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001264012.1|ensembl:ENSG00000222038(gene)|ensembl:ENST00000409602(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005615"(extracellular space)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002110(Ankyrin)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020683|interpro:IPR020902|interpro:IPR036770|interpro:IPR039497|interpro:IPR043129	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FjaGG32SBA1jpjo0RFJpJ0gAyM89606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P38919	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-299104|ensembl:ENSP00000497641|ensembl:ENSP00000497661|uniprotkb:Q15033|uniprotkb:Q96A18|uniprotkb:Q6IBQ2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4a3_human(display_long)|uniprotkb:KIAA0111(gene name synonym)|uniprotkb:EIF4A3(gene name)|psi-mi:EIF4A3(display_short)|uniprotkb:DDX48(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4A isoform 3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-3(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DDX48(gene name synonym)|uniprotkb:DEAD box protein 48(gene name synonym)|uniprotkb:Eukaryotic initiation factor 4A-like NUK-34(gene name synonym)|uniprotkb:Nuclear matrix protein 265(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008306"(associative learning)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035640"(exploration behavior)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072715"(cellular response to selenite ion)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904570"(negative regulation of selenocysteine incorporation)|go:"GO:1904574"(negative regulation of selenocysteine insertion sequence binding)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P38919|rcsb pdb:2HXY|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:4C9B|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6YVH|rcsb pdb:7A5P|reactome:R-HSA-1169408|reactome:R-HSA-159236|reactome:R-HSA-429947|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|ensembl:ENST00000647795(transcript)|ensembl:ENST00000649764(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|ensembl:ENSG00000141543(gene)|refseq:NP_055555.1|dip:DIP-33218N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8e6e4HlM1GsYqqgXyJ9XgzxLzls9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9ULH7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-493007|uniprotkb:A6ND53|uniprotkb:Q68CT1|uniprotkb:Q6UB16|uniprotkb:Q86WW2|uniprotkb:Q8N226|uniprotkb:B4DGT8|intact:EBI-28976812	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mrtfb_human(display_long)|uniprotkb:MRTFB(gene name)|psi-mi:MRTFB(display_short)|uniprotkb:KIAA1243(gene name synonym)|uniprotkb:MKL/myocardin-like protein 2(gene name synonym)|uniprotkb:MKL2(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006720977.1|refseq:NP_054767.3|interpro:IPR004018(RPEL repeat)|interpro:IPR003034(DNA-binding SAP)|ensembl:ENST00000318282|ensembl:ENSP00000339086|ensembl:ENSG00000186260|ensembl:ENST00000571589|ensembl:ENSP00000459626|ensembl:ENST00000573051|ensembl:ENSP00000460589|ensembl:ENST00000574045|ensembl:ENSP00000459205|refseq:NP_001295071.1|refseq:XP_011520870.1|interpro:IPR043451|refseq:XP_005255512.1|refseq:XP_005255509.1|refseq:XP_005255510.1|refseq:XP_006720971.1|refseq:XP_006720972.1|refseq:XP_016878990.1|refseq:XP_016878991.1|mint:Q9ULH7|interpro:IPR036361|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0007517"(muscle organ development)|go:"GO:0045296"(cadherin binding)|go:"GO:0045844"(positive regulation of striated muscle tissue development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FEDyi3ECPX5T1KSwNjOZ/lWG1RY9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06733	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07900	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P08238	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P14618	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P04406	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955247|imex:IM-28889-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	comment:"Cells were treated with sodium arsenite (0.5 mM, 30 min) to induce stress granule formation."|comment:"After eliminating proteins found in only one of three replicate samples or present at high levels the CRAPome, 211 necdin-proximal proteins were identified in arsenite stressed cells (Suppl. Table 1)."|figure legend:ST1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:7Psto0K2qdv5dHiR18PQTG+vwW4	false	fusion protein:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6P1N0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-7112364|intact:EBI-28978458|ensembl:ENSP00000313601|ensembl:ENSP00000500461|intact:MINT-4827481|uniprotkb:Q7Z435|uniprotkb:Q86XV0|uniprotkb:Q9H603|uniprotkb:Q8NF89|uniprotkb:Q9NXI1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c2d1a_human(display_long)|uniprotkb:CC2D1A(gene name)|psi-mi:CC2D1A(display_short)|uniprotkb:AKI1(gene name synonym)|uniprotkb:Akt kinase-interacting protein 1(gene name synonym)|uniprotkb:Five prime repressor element under dual repression-binding protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 023N(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000313601|ensembl:ENST00000589606|ensembl:ENSP00000467526|ensembl:ENSP00000500461|ensembl:ENST00000672339|ensembl:ENSP00000500343|ensembl:ENSG00000132024(gene)|ensembl:ENSG00000288293(gene)|ensembl:ENST00000318003(transcript)|ensembl:ENST00000672017(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905381"(negative regulation of snRNA transcription by RNA polymerase II)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006608(Protein of unknown function DM14)|interpro:IPR035892|interpro:IPR037772|interpro:IPR039725|refseq:NP_060191.3|refseq:XP_005260030.1	-	-	comment:mint|comment:homomint|function:"Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell"|function:"Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3) [MIM:608443]. Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs"	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:epJzfetEvVa5rJirbt3Ox8cEkqA9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UKA4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049491|uniprotkb:O75124|uniprotkb:Q9NUK7|ensembl:ENSP00000025301	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:aka11_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 11(gene name synonym)|uniprotkb:A-kinase anchor protein 220 kDa(gene name synonym)|uniprotkb:AKAP11(gene name)|psi-mi:AKAP11(display_short)|uniprotkb:AKAP220(gene name synonym)|uniprotkb:KIAA0629(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_011533205.1|refseq:XP_011533206.1|refseq:XP_011533207.1|refseq:XP_011533208.1|refseq:NP_057332.1|refseq:XP_016875870.1|ensembl:ENSG00000023516(gene)|ensembl:ENST00000025301(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR008382(A-kinase anchor 110 kDa)|mint:Q9UKA4	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:EoQOZuPirXCY2k5migb2Fr6utZ09606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P28288	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYK2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11110166|ensembl:ENSP00000440901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyk2_human(display_long)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090372(gene)|ensembl:ENST00000539396(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CWwVsvNBEouYub9DRx3ykuw6Wqg9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W726	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955080|ensembl:ENSP00000271877	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w726_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143569(gene)|ensembl:ENST00000271877(transcript)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001317659.1|refseq:XP_016858474.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ubziKKFRBd1iMzyzCDu/sNF1+T09606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PPJ0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10177154|ensembl:ENSP00000432655	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9ppj0_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000087365(gene)|ensembl:ENST00000528302(transcript)|go:"GO:0016607"(nuclear speck)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|interpro:IPR007180(Protein of unknown function DUF382)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nkmgro5nnggAfRRO7SlKnRxSMsU9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BUF6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955067|ensembl:ENSP00000457613	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3buf6_human(display_long)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000564304(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|refseq:NP_001295159.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:deregvuN/2hveFXyezm8WFOtXqs9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H0Y2V6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11022356|ensembl:ENSP00000338161	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h0y2v6_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143702(gene)|ensembl:ENST00000336415(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0072686"(mitotic spindle)|interpro:IPR026644|interpro:IPR029300	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JPDQK8U8dVkFcGB/BRM1MK6yL5g9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SFB3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955049|ensembl:ENSP00000486443	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sfb3_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215301(gene)|ensembl:ENST00000626301(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016787"(hydrolase activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3HBCl/lJwdnqa4IyzA2ToiWUcJw9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L1L3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955034|ensembl:ENSP00000458919	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l1l3_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|ensembl:ENSG00000132382(gene)|ensembl:ENST00000573116(transcript)|go:"GO:0003677"(DNA binding)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nINs4THVlRPw4Bpgit3pSmMPghA9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y2Z0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95905	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2557598|ensembl:ENSP00000362070|uniprotkb:C9JX46|uniprotkb:E9PAW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ecd_human(display_long)|uniprotkb:Human suppressor of GCR two(gene name synonym)|uniprotkb:ECD(gene name)|psi-mi:ECD(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129225.1|refseq:NP_009196.1|ensembl:ENSG00000122882(gene)|ensembl:ENST00000372979(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR010770(SGT1)|refseq:NP_001129224.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7uvREpWu7KW0cAo8zcf7SSkaQiY9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EX73	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955017|ensembl:ENSP00000399858	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7ex73_human(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000114867(gene)|ensembl:ENST00000441154(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1qdHA6IrcrYFYKmrDfOt8zNV/W49606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P40855	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1ANR0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-9977484|ensembl:ENSP00000361953	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WTT1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955001|ensembl:ENSP00000478108	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wtt1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000070756(gene)|ensembl:ENST00000610907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|interpro:IPR000504(RNA recognition motif, RNP-1)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cK4lGsqOggjFbeqhmhHwrjWSECA9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P04406	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BY89	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-8796741|intact:EBI-28980779|ensembl:ENSP00000351207|ensembl:ENSP00000385152|uniprotkb:B7ZW08|uniprotkb:Q5THZ5|uniprotkb:B0QYF2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:k1671_human(display_long)|uniprotkb:KIAA1671(gene name)|psi-mi:KIAA1671(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000197077(gene)|ensembl:ENST00000358431(transcript)|ensembl:ENST00000406486(transcript)|interpro:IPR032764|interpro:IPR040006|ensembl:ENSP00000351207|ensembl:ENST00000401395|ensembl:ENSP00000385377|ensembl:ENSP00000385152|refseq:XP_005261850.1|refseq:XP_005261851.1|refseq:NP_001138678.1|refseq:XP_006724409.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7mCSVXo/8Z2MUHqsxKKXrBvOe749606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75152	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-748480|uniprotkb:Q6AHY4|uniprotkb:Q6AHY9|uniprotkb:Q6AW79|uniprotkb:Q6AWA1|uniprotkb:Q6PJK4|uniprotkb:Q86XZ7|ensembl:ENSP00000333253|ensembl:ENSP00000356179|ensembl:ENSP00000356181|ensembl:ENSP00000356183|ensembl:ENSP00000491830	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:zc11a_human(display_long)|uniprotkb:ZC3H11A(gene name)|psi-mi:ZC3H11A(display_short)|uniprotkb:KIAA0663(gene name synonym)|uniprotkb:ZC3HDC11A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006711736.1|refseq:NP_055642.3|refseq:XP_011508501.1|refseq:XP_011508502.1|refseq:XP_011508503.1|refseq:XP_011508504.1|refseq:NP_001306167.1|refseq:NP_001306168.1|refseq:XP_005245700.1|refseq:XP_005245701.1|refseq:XP_016858445.1|refseq:XP_016858446.1|refseq:XP_016858447.1|refseq:XP_016858448.1|ensembl:ENSG00000058673(gene)|ensembl:ENST00000332127(transcript)|ensembl:ENST00000367210(transcript)|ensembl:ENST00000367212(transcript)|ensembl:ENST00000367214(transcript)|ensembl:ENST00000639812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR041686|mint:O75152|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:BJfX/K7kBXQGQx6l+Y2xBtwyJAw9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9HB71	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26956515|imex:IM-28889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/19	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	rigid:/lcZgrYhSXfdj6AoGE3/Ls4CC8Q	false	mutation with complex effect:66-66|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6P1N0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-7112364|intact:EBI-28978458|ensembl:ENSP00000313601|ensembl:ENSP00000500461|intact:MINT-4827481|uniprotkb:Q7Z435|uniprotkb:Q86XV0|uniprotkb:Q9H603|uniprotkb:Q8NF89|uniprotkb:Q9NXI1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:c2d1a_human(display_long)|uniprotkb:CC2D1A(gene name)|psi-mi:CC2D1A(display_short)|uniprotkb:AKI1(gene name synonym)|uniprotkb:Akt kinase-interacting protein 1(gene name synonym)|uniprotkb:Five prime repressor element under dual repression-binding protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 023N(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000313601|ensembl:ENST00000589606|ensembl:ENSP00000467526|ensembl:ENSP00000500461|ensembl:ENST00000672339|ensembl:ENSP00000500343|ensembl:ENSG00000132024(gene)|ensembl:ENSG00000288293(gene)|ensembl:ENST00000318003(transcript)|ensembl:ENST00000672017(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905381"(negative regulation of snRNA transcription by RNA polymerase II)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006608(Protein of unknown function DM14)|interpro:IPR035892|interpro:IPR037772|interpro:IPR039725|refseq:NP_060191.3|refseq:XP_005260030.1	-	-	comment:mint|comment:homomint|function:"Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell"|function:"Defects in CC2D1A are the cause of non-syndromic mental retardation autosomal recessive type 3 (MRT3) [MIM:608443]. Patients display severe mental retardation and psychomotor development delay in early childhood. Non-syndromic mental retardation patients do not manifest other clinical signs"	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:epJzfetEvVa5rJirbt3Ox8cEkqA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UKA4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049491|uniprotkb:O75124|uniprotkb:Q9NUK7|ensembl:ENSP00000025301	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:aka11_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 11(gene name synonym)|uniprotkb:A-kinase anchor protein 220 kDa(gene name synonym)|uniprotkb:AKAP11(gene name)|psi-mi:AKAP11(display_short)|uniprotkb:AKAP220(gene name synonym)|uniprotkb:KIAA0629(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_011533205.1|refseq:XP_011533206.1|refseq:XP_011533207.1|refseq:XP_011533208.1|refseq:NP_057332.1|refseq:XP_016875870.1|ensembl:ENSG00000023516(gene)|ensembl:ENST00000025301(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR008382(A-kinase anchor 110 kDa)|mint:Q9UKA4	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:EoQOZuPirXCY2k5migb2Fr6utZ09606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8N3C0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYK2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11110166|ensembl:ENSP00000440901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyk2_human(display_long)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090372(gene)|ensembl:ENST00000539396(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CWwVsvNBEouYub9DRx3ykuw6Wqg9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W726	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955080|ensembl:ENSP00000271877	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w726_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143569(gene)|ensembl:ENST00000271877(transcript)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001317659.1|refseq:XP_016858474.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ubziKKFRBd1iMzyzCDu/sNF1+T09606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E9PPJ0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10177154|ensembl:ENSP00000432655	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e9ppj0_human(display_long)|uniprotkb:SF3B2(gene name)|psi-mi:SF3B2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000087365(gene)|ensembl:ENST00000528302(transcript)|go:"GO:0016607"(nuclear speck)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006568(PSP, proline-rich)|interpro:IPR007180(Protein of unknown function DUF382)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nkmgro5nnggAfRRO7SlKnRxSMsU9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BUF6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955067|ensembl:ENSP00000457613	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3buf6_human(display_long)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000564304(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|refseq:NP_001295159.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:deregvuN/2hveFXyezm8WFOtXqs9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H0Y2V6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11022356|ensembl:ENSP00000338161	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h0y2v6_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143702(gene)|ensembl:ENST00000336415(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0072686"(mitotic spindle)|interpro:IPR026644|interpro:IPR029300	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JPDQK8U8dVkFcGB/BRM1MK6yL5g9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SFB3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955049|ensembl:ENSP00000486443	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sfb3_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215301(gene)|ensembl:ENST00000626301(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016787"(hydrolase activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3HBCl/lJwdnqa4IyzA2ToiWUcJw9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:I3L1L3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955034|ensembl:ENSP00000458919	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:i3l1l3_human(display_long)|uniprotkb:MYBBP1A(gene name)|psi-mi:MYBBP1A(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR007015(DNA polymerase V)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|ensembl:ENSG00000132382(gene)|ensembl:ENST00000573116(transcript)|go:"GO:0003677"(DNA binding)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:nINs4THVlRPw4Bpgit3pSmMPghA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y2Z0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95905	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2557598|ensembl:ENSP00000362070|uniprotkb:C9JX46|uniprotkb:E9PAW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ecd_human(display_long)|uniprotkb:Human suppressor of GCR two(gene name synonym)|uniprotkb:ECD(gene name)|psi-mi:ECD(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129225.1|refseq:NP_009196.1|ensembl:ENSG00000122882(gene)|ensembl:ENST00000372979(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR010770(SGT1)|refseq:NP_001129224.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7uvREpWu7KW0cAo8zcf7SSkaQiY9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EX73	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955017|ensembl:ENSP00000399858	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7ex73_human(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000114867(gene)|ensembl:ENST00000441154(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1qdHA6IrcrYFYKmrDfOt8zNV/W49606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96GA3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558389|uniprotkb:Q96JX8|ensembl:ENSP00000356548	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ltv1_human(display_long)|uniprotkb:LTV1(gene name)|psi-mi:LTV1(display_short)|uniprotkb:C6orf93(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116249.2|ensembl:ENSG00000135521(gene)|ensembl:ENST00000367576(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007307(Low temperature viability protein)|mint:Q96GA3|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|reactome:R-HSA-6791226	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Csfx8GS5hoclLY1BYki/uUKoSIM9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1ANR0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-9977484|ensembl:ENSP00000361953	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WTT1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955001|ensembl:ENSP00000478108	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wtt1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000070756(gene)|ensembl:ENST00000610907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|interpro:IPR000504(RNA recognition motif, RNP-1)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cK4lGsqOggjFbeqhmhHwrjWSECA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BV29	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2874058|uniprotkb:Q8N788|uniprotkb:Q86TC4|uniprotkb:A8KAL4|uniprotkb:Q8NAR7|ensembl:ENSP00000350695|ensembl:ENSP00000397515|ensembl:ENSP00000453226|ensembl:ENSP00000453607	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ccd32_human(display_long)|uniprotkb:CCDC32(gene name)|psi-mi:CCDC32(display_short)|uniprotkb:C15orf57(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001074260.1|refseq:NP_001074261.1|refseq:NP_443081.1|refseq:NP_001276061.1|ensembl:ENSG00000128891(gene)|ensembl:ENST00000358005(transcript)|ensembl:ENST00000416810(transcript)|ensembl:ENST00000559153(transcript)|ensembl:ENST00000559291(transcript)|interpro:IPR028039	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:14q1XZQbNJwvZwXPIvJXCaGRc/w9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O14654	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356594|ensembl:ENSP00000505547	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92667	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2119593|uniprotkb:Q13320|uniprotkb:Q9BW14|uniprotkb:A8K8Q1|uniprotkb:D3DTZ0|ensembl:ENSP00000337736|ensembl:ENSP00000443139|ensembl:ENSP00000459895|ensembl:ENSP00000459968|ensembl:ENSP00000478212	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:akap1_human(display_long)|uniprotkb:AKAP1(gene name)|psi-mi:AKAP1(display_short)|uniprotkb:AKAP149(gene name synonym)|uniprotkb:PRKA1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:A-kinase anchor protein 149 kDa(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein 84(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_016880678.1|refseq:XP_016880679.1|refseq:XP_016880680.1|refseq:NP_001229831.1|refseq:NP_001229832.1|refseq:NP_003479.1|refseq:XP_005257764.1|refseq:XP_005257766.1|ensembl:ENSG00000121057(gene)|ensembl:ENST00000337714(transcript)|ensembl:ENST00000539273(transcript)|ensembl:ENST00000571629(transcript)|ensembl:ENST00000572557(transcript)|ensembl:ENST00000621116(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:Q92667|reactome:R-HSA-8949215|reactome:R-HSA-983231	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8HzwuoBdBWw+LZKg6WpYxMKnfYE9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BY89	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-8796741|intact:EBI-28980779|ensembl:ENSP00000351207|ensembl:ENSP00000385152|uniprotkb:B7ZW08|uniprotkb:Q5THZ5|uniprotkb:B0QYF2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:k1671_human(display_long)|uniprotkb:KIAA1671(gene name)|psi-mi:KIAA1671(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000197077(gene)|ensembl:ENST00000358431(transcript)|ensembl:ENST00000406486(transcript)|interpro:IPR032764|interpro:IPR040006|ensembl:ENSP00000351207|ensembl:ENST00000401395|ensembl:ENSP00000385377|ensembl:ENSP00000385152|refseq:XP_005261850.1|refseq:XP_005261851.1|refseq:NP_001138678.1|refseq:XP_006724409.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7mCSVXo/8Z2MUHqsxKKXrBvOe749606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96A65	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96G28	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2654750|uniprotkb:Q53ST9|uniprotkb:Q6UY34|uniprotkb:Q53SF0|intact:EBI-28976235|ensembl:ENSP00000295117	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cfa36_human(display_long)|uniprotkb:CFAP36(gene name)|psi-mi:CFAP36(display_short)|uniprotkb:CCDC104(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 104(gene name synonym)|uniprotkb:UNQ163/PRO189(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001269690.1|ensembl:ENST00000339012|ensembl:ENSP00000342699|ensembl:ENSP00000295117|refseq:NP_542398.3|ensembl:ENSG00000163001(gene)|ensembl:ENST00000349456(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005930"(axoneme)|go:"GO:0031514"(motile cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097546"(ciliary base)|interpro:IPR023379|interpro:IPR038888|interpro:IPR042541|dip:DIP-57013N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:JQO4Xpav6rJoF1SOfxInk5Fuibk9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9HB71	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9NYL9	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352614|ensembl:ENSP00000308753|uniprotkb:Q9NT43|uniprotkb:Q9NZR0|uniprotkb:B2R6G7	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:tmod3_human(display_long)|uniprotkb:TMOD3(gene name)|psi-mi:TMOD3(display_short)|uniprotkb:Ubiquitous tropomodulin(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000138594(gene)|ensembl:ENST00000308580(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|refseq:NP_055362.1|go:"GO:0048821"(erythrocyte development)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR004934(Tropomodulin)|interpro:IPR030133|interpro:IPR032675|mint:Q9NYL9|reactome:R-HSA-390522|reactome:R-HSA-9013418|reactome:R-HSA-9696264|refseq:XP_016877576.1|refseq:XP_016877577.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:crEfCAAepSPAE8ByBpD4Sr14P5I9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P28288	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H845	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P40855	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92625	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1048612|uniprotkb:Q5JYI9|uniprotkb:Q5SYR2|uniprotkb:Q86WQ7|uniprotkb:A2RUC1|ensembl:ENSP00000353518|uniprotkb:B4DQW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ans1a_human(display_long)|uniprotkb:Odin(gene name synonym)|uniprotkb:ANKS1A(gene name)|psi-mi:ANKS1A(display_short)|uniprotkb:ANKS1(gene name synonym)|uniprotkb:KIAA0229(gene name synonym)|uniprotkb:ODIN(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056060.2|ensembl:ENSG00000064999(gene)|ensembl:ENST00000360359(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006929"(substrate-dependent cell migration)|go:"GO:0016322"(neuron remodeling)|go:"GO:0043005"(neuron projection)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1901187"(regulation of ephrin receptor signaling pathway)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033637|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|mint:Q92625|rcsb pdb:2LMR|rcsb pdb:2MYQ|rcsb pdb:6F7O	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VTw7RU5nIxHSxvQdBUT/YFlQzU89606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6GYQ0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-3957100|uniprotkb:A6NMA4|uniprotkb:C5NU19|uniprotkb:O94960|uniprotkb:Q6GYP9|uniprotkb:Q6ZT23|uniprotkb:Q86YF3|uniprotkb:Q86YF5|uniprotkb:Q8ND69|uniprotkb:B9EK38|ensembl:ENSP00000374348	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:rgpa1_human(display_long)|uniprotkb:RALGAPA1(gene name)|psi-mi:RALGAPA1(display_short)|uniprotkb:GARNL1(gene name synonym)|uniprotkb:KIAA0884(gene name synonym)|uniprotkb:TULIP1(gene name synonym)|uniprotkb:GAP-related-interacting partner to E12(gene name synonym)|uniprotkb:GTPase-activating Rap/Ran-GAP domain-like 1(gene name synonym)|uniprotkb:Tuberin-like protein 1(gene name synonym)|uniprotkb:p240(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001269972.1|refseq:NP_001269973.1|refseq:NP_055805.1|refseq:NP_919277.2|refseq:NP_001333172.1|refseq:NP_001333174.1|refseq:NP_001333175.1|refseq:NP_001333176.1|refseq:NP_001333177.1|refseq:NP_001333178.1|refseq:NP_001317004.1|ensembl:ENSG00000174373(gene)|ensembl:ENST00000389698(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027107|interpro:IPR035974|mint:Q6GYQ0|reactome:R-HSA-9013407	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:355FJfQ+hIi8gkQQ+IAsF6xHuKU9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P63151	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:evS6klM2alZXtMthVsshKkrNgiA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P12277	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357706|uniprotkb:Q2LE07|uniprotkb:A8K236|uniprotkb:B2R5R4|uniprotkb:Q6FG40|uniprotkb:Q9UC66|ensembl:ENSP00000299198	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kcrb_human(display_long)|uniprotkb:CKB(gene name)|psi-mi:CKB(display_short)|uniprotkb:CKBB(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:Brain creatine kinase(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001814.2|go:"GO:0005829"(cytosol)|ensembl:ENSG00000166165(gene)|ensembl:ENST00000348956(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12277|rcsb pdb:3B6R|rcsb pdb:3DRB|rcsb pdb:3DRE|rcsb pdb:6V9H|go:"GO:0021762"(substantia nigra development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046314"(phosphocreatine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-71288|reactome:R-HSA-9696264|dip:DIP-52968N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WLRnU8sRUfJQoaPY0edGi9xiR+g9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P23526	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07195	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P00338	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P04406	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06744	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558394|uniprotkb:Q9UHE6|uniprotkb:Q9BSK5|uniprotkb:Q9BRD3|ensembl:ENSP00000348877|uniprotkb:B4DG39	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g6pi_human(display_long)|uniprotkb:GPI(gene name)|psi-mi:GPI(display_short)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)|uniprotkb:Autocrine motility factor(gene name synonym)|uniprotkb:Neuroleukin(gene name synonym)|uniprotkb:Sperm antigen 36(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000166.2|ensembl:ENSG00000105220(gene)|ensembl:ENST00000356487(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007599"(hemostasis)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:1IAT|rcsb pdb:1IRI|rcsb pdb:1JIQ|rcsb pdb:1JLH|rcsb pdb:1NUH|rcsb pdb:6XUH|rcsb pdb:6XUI|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-5628897|refseq:NP_001171651.1|refseq:NP_001316838.1|refseq:NP_001316839.1|refseq:NP_001316840.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:R3ftNtHikgoVdqLjC4d6I5lpENU9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y4W2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O75152	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-748480|uniprotkb:Q6AHY4|uniprotkb:Q6AHY9|uniprotkb:Q6AW79|uniprotkb:Q6AWA1|uniprotkb:Q6PJK4|uniprotkb:Q86XZ7|ensembl:ENSP00000333253|ensembl:ENSP00000356179|ensembl:ENSP00000356181|ensembl:ENSP00000356183|ensembl:ENSP00000491830	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:zc11a_human(display_long)|uniprotkb:ZC3H11A(gene name)|psi-mi:ZC3H11A(display_short)|uniprotkb:KIAA0663(gene name synonym)|uniprotkb:ZC3HDC11A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006711736.1|refseq:NP_055642.3|refseq:XP_011508501.1|refseq:XP_011508502.1|refseq:XP_011508503.1|refseq:XP_011508504.1|refseq:NP_001306167.1|refseq:NP_001306168.1|refseq:XP_005245700.1|refseq:XP_005245701.1|refseq:XP_016858445.1|refseq:XP_016858446.1|refseq:XP_016858447.1|refseq:XP_016858448.1|ensembl:ENSG00000058673(gene)|ensembl:ENST00000332127(transcript)|ensembl:ENST00000367210(transcript)|ensembl:ENST00000367212(transcript)|ensembl:ENST00000367214(transcript)|ensembl:ENST00000639812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR041686|mint:O75152|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:BJfX/K7kBXQGQx6l+Y2xBtwyJAw9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q7Z417	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8IZH2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q659C4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-3940258|uniprotkb:Q7Z3F7|uniprotkb:Q8N6F4|uniprotkb:Q4W599|uniprotkb:Q4W5B2|uniprotkb:Q86VK7|uniprotkb:Q9NW12|uniprotkb:Q2YDB6|uniprotkb:Q6P5X2|uniprotkb:Q8N7H4|uniprotkb:Q8NAF2|uniprotkb:Q659A0|uniprotkb:Q9H5E7|ensembl:ENSP00000321997	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:lar1b_human(display_long)|uniprotkb:LARP1B(gene name)|psi-mi:LARP1B(display_short)|uniprotkb:LARP2(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 1B(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 2(gene name synonym)|uniprotkb:La-related protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_011530371.1|ensembl:ENSG00000138709(gene)|ensembl:ENST00000326639(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q659C4|refseq:NP_060548.2|refseq:NP_001265533.1|refseq:NP_115615.2|refseq:NP_835144.1|refseq:XP_016863842.1|dip:DIP-47319N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:XWm5ayrwpbkUOVcx/L9fA9egmU89606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P67809	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O43432	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q92616	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957193|imex:IM-28889-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1	-	-	-	figure legend:F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/20	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606	rigid:flDnynUvkqO9TWvOBmLTVIj0uD0	false	mutation with complex effect:265-265|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UKA4	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049491|uniprotkb:O75124|uniprotkb:Q9NUK7|ensembl:ENSP00000025301	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:aka11_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 11(gene name synonym)|uniprotkb:A-kinase anchor protein 220 kDa(gene name synonym)|uniprotkb:AKAP11(gene name)|psi-mi:AKAP11(display_short)|uniprotkb:AKAP220(gene name synonym)|uniprotkb:KIAA0629(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_011533205.1|refseq:XP_011533206.1|refseq:XP_011533207.1|refseq:XP_011533208.1|refseq:NP_057332.1|refseq:XP_016875870.1|ensembl:ENSG00000023516(gene)|ensembl:ENST00000025301(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR008382(A-kinase anchor 110 kDa)|mint:Q9UKA4	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:EoQOZuPirXCY2k5migb2Fr6utZ09606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F5GYK2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-11110166|ensembl:ENSP00000440901	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f5gyk2_human(display_long)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090372(gene)|ensembl:ENST00000539396(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:CWwVsvNBEouYub9DRx3ykuw6Wqg9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:F8W726	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955080|ensembl:ENSP00000271877	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:f8w726_human(display_long)|uniprotkb:UBAP2L(gene name)|psi-mi:UBAP2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000143569(gene)|ensembl:ENST00000271877(transcript)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001317659.1|refseq:XP_016858474.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ubziKKFRBd1iMzyzCDu/sNF1+T09606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:H3BUF6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955067|ensembl:ENSP00000457613	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:h3buf6_human(display_long)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000564304(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|refseq:NP_001295159.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:deregvuN/2hveFXyezm8WFOtXqs9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A0D9SFB3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955049|ensembl:ENSP00000486443	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a0d9sfb3_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000215301(gene)|ensembl:ENST00000626301(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016787"(hydrolase activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3HBCl/lJwdnqa4IyzA2ToiWUcJw9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9Y2Z0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:E7EX73	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955017|ensembl:ENSP00000399858	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:e7ex73_human(display_long)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000114867(gene)|ensembl:ENST00000441154(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:1qdHA6IrcrYFYKmrDfOt8zNV/W49606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:B1ANR0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-9977484|ensembl:ENSP00000361953	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:A0A087WTT1	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-26955001|ensembl:ENSP00000478108	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:a0a087wtt1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000070756(gene)|ensembl:ENST00000610907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|interpro:IPR000504(RNA recognition motif, RNP-1)	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:cK4lGsqOggjFbeqhmhHwrjWSECA9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957317|imex:IM-28889-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/27	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:/VWatoiHBE6fe3YWmoW0a38ZU54	false	mutation with complex effect:109-109,110-110|fusion protein:c-c|flag tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95373	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q7Z417	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:zdbkRisveP+8g70umfbEPHTnAgk9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96P70	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O14654	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356594|ensembl:ENSP00000505547	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8N3C0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q08211	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352022|intact:EBI-1058470|uniprotkb:Q5VY62|uniprotkb:Q6PD69|uniprotkb:Q99556|uniprotkb:B2RNV4|uniprotkb:Q05CI5|uniprotkb:Q12803|uniprotkb:Q32Q22|ensembl:ENSP00000356520	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:dhx9_human(display_long)|uniprotkb:DHX9(gene name)|psi-mi:DHX9(display_short)|uniprotkb:DDX9(gene name synonym)|uniprotkb:NDH2(gene name synonym)|uniprotkb:DExH-box helicase 9(gene name synonym)|uniprotkb:RNA helicase A(gene name synonym)|uniprotkb:LKP(gene name synonym)|uniprotkb:Nuclear DNA helicase II(gene name synonym)|uniprotkb:DEAH box protein 9(gene name synonym)|uniprotkb:Leukophysin(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001348.2|dip:DIP-31504N|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070269"(pyroptosis)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000765"(regulation of cytoplasmic translation)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|mint:Q08211|rcsb pdb:3LLM|rcsb pdb:3VYX|rcsb pdb:3VYY|reactome:R-HSA-1810476|reactome:R-HSA-3134963|reactome:R-HSA-72163|go:"GO:1904973"(positive regulation of viral translation)|ensembl:ENSG00000135829(gene)|ensembl:ENST00000367549(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006260"(DNA replication)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:b0VP2Frtvwa9WbYVMwB6TbV2uGU9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P67809	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354065|uniprotkb:P16990|uniprotkb:P16991|uniprotkb:Q14972|uniprotkb:Q15325|uniprotkb:Q5FVF0|ensembl:ENSP00000361626	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ybox1_human(display_long)|uniprotkb:YBX1(gene name)|psi-mi:YBX1(display_short)|uniprotkb:YB1(gene name synonym)|uniprotkb:NSEP1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004550.2|dip:DIP-29405N|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P67809|rcsb pdb:1H95|rcsb pdb:5YTS|rcsb pdb:5YTT|rcsb pdb:5YTV|rcsb pdb:5YTX|rcsb pdb:6A6L|rcsb pdb:6KTC|rcsb pdb:6KUG|rcsb pdb:6LMR|rcsb pdb:6LMS|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-9017802|ensembl:ENSG00000065978(gene)|ensembl:ENST00000321358(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0/mAXOzokPlDByFFzGTP8bp9nqo9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P43243	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q96GA3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558389|uniprotkb:Q96JX8|ensembl:ENSP00000356548	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ltv1_human(display_long)|uniprotkb:LTV1(gene name)|psi-mi:LTV1(display_short)|uniprotkb:C6orf93(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116249.2|ensembl:ENSG00000135521(gene)|ensembl:ENST00000367576(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007307(Low temperature viability protein)|mint:Q96GA3|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|reactome:R-HSA-6791226	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Csfx8GS5hoclLY1BYki/uUKoSIM9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O95905	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2557598|ensembl:ENSP00000362070|uniprotkb:C9JX46|uniprotkb:E9PAW8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ecd_human(display_long)|uniprotkb:Human suppressor of GCR two(gene name synonym)|uniprotkb:ECD(gene name)|psi-mi:ECD(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129225.1|refseq:NP_009196.1|ensembl:ENSG00000122882(gene)|ensembl:ENST00000372979(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR010770(SGT1)|refseq:NP_001129224.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:7uvREpWu7KW0cAo8zcf7SSkaQiY9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H6S0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1057466|uniprotkb:B2RP66|ensembl:ENSP00000161863	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ytdc2_human(display_long)|uniprotkb:YTHDC2(gene name)|psi-mi:YTHDC2(display_short)|uniprotkb:YTH domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_073739.3|ensembl:ENSG00000047188(gene)|ensembl:ENST00000161863(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:Q9H6S0|rcsb pdb:2YU6|rcsb pdb:6K6U|refseq:XP_016865219.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8J8b1Q3F6rfXUwtp7EOeU2y89Lc9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8WWM7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P00338	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-372327|uniprotkb:Q53G53|uniprotkb:Q6IBM7|uniprotkb:Q6ZNV1|ensembl:ENSP00000368722|ensembl:ENSP00000395337|ensembl:ENSP00000445331|ensembl:ENSP00000499898|ensembl:ENSP00000499977|ensembl:ENSP00000500953|uniprotkb:Q9UDE8|uniprotkb:Q9UDE9|uniprotkb:D3DQY3|uniprotkb:B7Z5E3|uniprotkb:B4DKQ2|uniprotkb:F8W819	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldha_human(display_long)|uniprotkb:LDHA(gene name)|psi-mi:LDHA(display_short)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-59(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 19 protein(gene name synonym)|uniprotkb:PIG19(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001158886.1|ensembl:ENSG00000134333(gene)|ensembl:ENSG00000288299(gene)|ensembl:ENST00000379412(transcript)|ensembl:ENST00000422447(transcript)|ensembl:ENST00000542179(transcript)|ensembl:ENST00000671981(transcript)|ensembl:ENST00000672405(transcript)|ensembl:ENST00000673204(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045296"(cadherin binding)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|rcsb pdb:1I10|mint:P00338|rcsb pdb:4AJP|rcsb pdb:4JNK|rcsb pdb:4L4R|rcsb pdb:4L4S|rcsb pdb:4M49|rcsb pdb:4OJN|rcsb pdb:4OKN|rcsb pdb:4QO7|rcsb pdb:4QO8|rcsb pdb:4QSM|rcsb pdb:4QT0|rcsb pdb:4R68|rcsb pdb:4R69|rcsb pdb:4RLS|rcsb pdb:4ZVV|rcsb pdb:5IXS|rcsb pdb:5IXY|rcsb pdb:5W8H|rcsb pdb:5W8I|rcsb pdb:5W8J|rcsb pdb:5W8K|rcsb pdb:5W8L|rcsb pdb:5ZJD|rcsb pdb:5ZJE|rcsb pdb:5ZJF|rcsb pdb:6BAD|rcsb pdb:6BAG|rcsb pdb:6BAX|rcsb pdb:6BAZ|rcsb pdb:6BB0|rcsb pdb:6BB1|rcsb pdb:6BB2|rcsb pdb:6BB3|rcsb pdb:6MV8|rcsb pdb:6MVA|rcsb pdb:6Q0D|rcsb pdb:6SBU|rcsb pdb:6SBV|rcsb pdb:6ZZR|reactome:R-HSA-70268|rcsb pdb:6Q13|refseq:NP_001158887.1|refseq:NP_005557.1|refseq:NP_001128711.1|refseq:NP_001158888.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Zpq2lAJLPG+q2bMEru3cq7B5gCk9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P28288	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:O00571	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06576	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06744	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2558394|uniprotkb:Q9UHE6|uniprotkb:Q9BSK5|uniprotkb:Q9BRD3|ensembl:ENSP00000348877|uniprotkb:B4DG39	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g6pi_human(display_long)|uniprotkb:GPI(gene name)|psi-mi:GPI(display_short)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)|uniprotkb:Autocrine motility factor(gene name synonym)|uniprotkb:Neuroleukin(gene name synonym)|uniprotkb:Sperm antigen 36(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000166.2|ensembl:ENSG00000105220(gene)|ensembl:ENST00000356487(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007599"(hemostasis)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|rcsb pdb:1IAT|rcsb pdb:1IRI|rcsb pdb:1JIQ|rcsb pdb:1JLH|rcsb pdb:1NUH|rcsb pdb:6XUH|rcsb pdb:6XUI|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-5628897|refseq:NP_001171651.1|refseq:NP_001316838.1|refseq:NP_001316839.1|refseq:NP_001316840.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:R3ftNtHikgoVdqLjC4d6I5lpENU9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P25705	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P49321	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-716205|uniprotkb:Q53GW5|uniprotkb:Q5T625|uniprotkb:Q5T622|uniprotkb:Q96A69|uniprotkb:Q9BTW2|uniprotkb:A8K6H2|uniprotkb:B4DQP3|uniprotkb:F5H3J2|uniprotkb:D3DQ07|intact:EBI-28989159|ensembl:ENSP00000255120	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:nasp_human(display_long)|uniprotkb:NASP(gene name)|psi-mi:NASP(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001182122.1|refseq:NP_002473.2|refseq:NP_689511.2|ensembl:ENSG00000132780(gene)|ensembl:ENST00000350030(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001824"(blastocyst development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0008584"(male gonad development)|go:"GO:0015031"(protein transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033574"(response to testosterone)|go:"GO:0034080"(CENP-A containing chromatin assembly)|go:"GO:0042393"(histone binding)|go:"GO:0043486"(histone exchange)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019544|interpro:IPR019734|mint:P49321|ensembl:ENSP00000255120|ensembl:ENST00000351223|ensembl:ENSP00000255121|ensembl:ENST00000537798|ensembl:ENSP00000438871|refseq:XP_005270945.1|dip:DIP-47269N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:8BOknyp+vOh6NF+fXZPYbbqFbH49606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6Y7W6	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q8NC51	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-523558|uniprotkb:Q8WUH0|uniprotkb:Q96SE2|uniprotkb:Q9BTY3|uniprotkb:Q9BUM4|uniprotkb:Q9Y367|uniprotkb:Q9Y4S3|uniprotkb:Q5VU19|intact:EBI-1058614|ensembl:ENSP00000360034|uniprotkb:Q5VU20|uniprotkb:Q5VU22	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pairb_human(display_long)|uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)|uniprotkb:SERPINE1 mRNA-binding protein 1(gene name synonym)|uniprotkb:CGI-55(orf name)|uniprotkb:SERBP1(gene name)|psi-mi:SERBP1(display_short)|uniprotkb:PAIRBP1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000142864(gene)|ensembl:ENST00000370995(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR027205|interpro:IPR032381|interpro:IPR039764|mint:Q8NC51|rcsb pdb:4V6X|rcsb pdb:6Z6M|rcsb pdb:6Z6N|refseq:NP_001018077.1|refseq:NP_001018078.1|refseq:NP_001018079.1|refseq:NP_056455.3|dip:DIP-33819N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:lVkIPRkoXs3B4Qop1pA2zG/RKlo9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P22626	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07195	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-358748|ensembl:ENSP00000229319|ensembl:ENSP00000379386	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ldhb_human(display_long)|uniprotkb:LDHB(gene name)|psi-mi:LDHB(display_short)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-46(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001167568.1|refseq:NP_002291.1|refseq:NP_001302466.1|ensembl:ENSG00000111716(gene)|ensembl:ENST00000350669(transcript)|ensembl:ENST00000396076(transcript)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P07195|rcsb pdb:1I0Z|rcsb pdb:1T2F|reactome:R-HSA-70268	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:umdj6fjSO7+4SM9Hrl1/K2EiKls9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P13639	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P23526	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q04637	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-73711|uniprotkb:O43177|uniprotkb:O95066|uniprotkb:Q5HYG0|uniprotkb:Q6ZN21|uniprotkb:Q8N102|intact:EBI-11020102|uniprotkb:D3DNT4|uniprotkb:D3DNT5|uniprotkb:D3DNT2|uniprotkb:E9PFM1|uniprotkb:G5E9S1|intact:EBI-28974642|ensembl:ENSP00000316879	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4g1_human(display_long)|uniprotkb:p220(gene name synonym)|uniprotkb:EIF4G1(gene name)|psi-mi:EIF4G1(display_short)|uniprotkb:EIF4G(gene name synonym)|uniprotkb:EIF4GI(gene name synonym)|uniprotkb:EIF4F(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENST00000342981|ensembl:ENSP00000343450|ensembl:ENSP00000316879|ensembl:ENST00000350481|ensembl:ENSP00000317600|ensembl:ENST00000352767|ensembl:ENSP00000338020|ensembl:ENST00000382330|ensembl:ENSP00000371767|ensembl:ENST00000392537|ensembl:ENSP00000376320|ensembl:ENST00000414031|ensembl:ENSP00000391935|ensembl:ENST00000424196|ensembl:ENSP00000416255|ensembl:ENST00000434061|ensembl:ENSP00000411826|refseq:NP_886553.3|refseq:NP_937884.1|refseq:NP_937885.1|refseq:NP_004944.3|dip:DIP-1161N|ensembl:ENSG00000114867(gene)|ensembl:ENST00000346169(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032502"(developmental process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097009"(energy homeostasis)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905537"(positive regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905612"(positive regulation of mRNA cap binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1905696"(regulation of polysome binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037584|mint:Q04637|rcsb pdb:1LJ2|rcsb pdb:1UG3|rcsb pdb:2W97|rcsb pdb:4AZA|rcsb pdb:4F02|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5T46|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:0UfVxxWOLUvrvFfcteeTc2RrbhA9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BR76	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351152|uniprotkb:B2RD45|ensembl:ENSP00000340211|ensembl:ENSP00000377471	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:cor1b_human(display_long)|uniprotkb:CORO1B(gene name)|psi-mi:CORO1B(display_short)|uniprotkb:Coronin-2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001018080.1|refseq:NP_065174.1|ensembl:ENSG00000172725(gene)|ensembl:ENST00000341356(transcript)|ensembl:ENST00000393893(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031529"(ruffle organization)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090135"(actin filament branching)|go:"GO:1902463"(protein localization to cell leading edge)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027340|interpro:IPR036322|mint:Q9BR76|go:"GO:0035767"(endothelial cell chemotaxis)|dip:DIP-33176N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:80hrtgIbLoisOZLGgfaa1TLBFMg9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P61978	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-304185|intact:EBI-28971491|ensembl:ENSP00000317788|ensembl:ENSP00000353552|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q59F98|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62|uniprotkb:Q5T6W4|intact:EBI-3440248|uniprotkb:Q6IBN1	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpk_human(display_long)|uniprotkb:HNRNPK(gene name)|psi-mi:HNRNPK(display_short)|uniprotkb:HNRPK(gene name synonym)|uniprotkb:Transformation up-regulated nuclear protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000165119(gene)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|ensembl:ENST00000351839(transcript)|ensembl:ENST00000360384(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0002102"(podosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006396"(RNA processing)|go:"GO:0007165"(signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61978|rcsb pdb:1J5K|rcsb pdb:1KHM|rcsb pdb:1ZZI|rcsb pdb:1ZZJ|go:"GO:0043066"(negative regulation of apoptotic process)|reactome:R-HSA-4570464|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9610379|rcsb pdb:1ZZK|refseq:NP_002131.2|refseq:NP_112552.1|refseq:NP_112553.1|ensembl:ENSP00000317788|ensembl:ENSP00000353552|ensembl:ENST00000376263|ensembl:ENSP00000365439|ensembl:ENST00000376281|ensembl:ENSP00000365458|refseq:NP_001305115.1|refseq:NP_001305116.1|refseq:NP_001305117.1|refseq:XP_016870157.1|refseq:XP_005252017.1|refseq:XP_005252020.1|refseq:XP_005252022.1|dip:DIP-31805N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9ULH7	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-493007|uniprotkb:A6ND53|uniprotkb:Q68CT1|uniprotkb:Q6UB16|uniprotkb:Q86WW2|uniprotkb:Q8N226|uniprotkb:B4DGT8|intact:EBI-28976812	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:mrtfb_human(display_long)|uniprotkb:MRTFB(gene name)|psi-mi:MRTFB(display_short)|uniprotkb:KIAA1243(gene name synonym)|uniprotkb:MKL/myocardin-like protein 2(gene name synonym)|uniprotkb:MKL2(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:XP_006720977.1|refseq:NP_054767.3|interpro:IPR004018(RPEL repeat)|interpro:IPR003034(DNA-binding SAP)|ensembl:ENST00000318282|ensembl:ENSP00000339086|ensembl:ENSG00000186260|ensembl:ENST00000571589|ensembl:ENSP00000459626|ensembl:ENST00000573051|ensembl:ENSP00000460589|ensembl:ENST00000574045|ensembl:ENSP00000459205|refseq:NP_001295071.1|refseq:XP_011520870.1|interpro:IPR043451|refseq:XP_005255512.1|refseq:XP_005255509.1|refseq:XP_005255510.1|refseq:XP_006720971.1|refseq:XP_006720972.1|refseq:XP_016878990.1|refseq:XP_016878991.1|mint:Q9ULH7|interpro:IPR036361|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0007517"(muscle organ development)|go:"GO:0045296"(cadherin binding)|go:"GO:0045844"(positive regulation of striated muscle tissue development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:FEDyi3ECPX5T1KSwNjOZ/lWG1RY9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q00839	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-351126|uniprotkb:O75507|uniprotkb:Q8N174|uniprotkb:Q96HY9|uniprotkb:Q9BQ09|ensembl:ENSP00000491215	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hnrpu_human(display_long)|uniprotkb:HNRNPU(gene name)|psi-mi:HNRNPU(display_short)|uniprotkb:SAFA(gene name synonym)|uniprotkb:U21.1(gene name synonym)|uniprotkb:HNRPU(gene name synonym)|uniprotkb:p120(gene name synonym)|uniprotkb:pp120(gene name synonym)|uniprotkb:C1orf199(gene name synonym)|uniprotkb:GRIP120(gene name synonym)|uniprotkb:Nuclear p120 ribonucleoprotein(gene name synonym)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_004492.2|refseq:NP_114032.2|ensembl:ENSG00000153187(gene)|ensembl:ENST00000640218(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q00839|rcsb pdb:1ZRJ|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006396"(RNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|refseq:XP_016856604.1|refseq:XP_016856605.1|refseq:XP_016856606.1|dip:DIP-684N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:n73PY0Vis+D5Iq0q77h5Ck2V4789606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9UBF2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1045840|uniprotkb:A6NH74|uniprotkb:Q54AC3|uniprotkb:Q8WVW8|ensembl:ENSP00000402346|uniprotkb:Q2NLA0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:copg2_human(display_long)|uniprotkb:Gamma-2-coat protein(gene name synonym)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001276962.1|refseq:NP_036265.3|ensembl:ENSG00000158623(gene)|ensembl:ENST00000425248(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9UBF2|reactome:R-HSA-6807878|reactome:R-HSA-6811434|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VEvct8z8lwNWbLs2GFPrKwk1GpE9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9H074	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P60842	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P09651	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352662|uniprotkb:Q3MIB7|uniprotkb:Q6PJZ7|ensembl:ENSP00000341826|ensembl:ENSP00000503610|uniprotkb:A8K4Z8|intact:EBI-2556572	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:roa1_human(display_long)|uniprotkb:HNRNPA1(gene name)|psi-mi:HNRNPA1(display_short)|uniprotkb:HNRPA1(gene name synonym)|uniprotkb:Helix-destabilizing protein(gene name synonym)|uniprotkb:Single-strand RNA-binding protein(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002127.1|refseq:NP_112420.1|ensembl:ENSG00000135486(gene)|ensembl:ENST00000340913(transcript)|ensembl:ENST00000677210(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|rcsb pdb:2LYV|rcsb pdb:2UP1|rcsb pdb:4YOE|rcsb pdb:5MPG|rcsb pdb:5MPL|rcsb pdb:5ZGD|rcsb pdb:5ZGL|rcsb pdb:6BXX|rcsb pdb:6DCL|rcsb pdb:6J60|rcsb pdb:7BX7|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035198"(miRNA binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051168"(nuclear export)|go:"GO:0051170"(import into nucleus)|go:"GO:0061752"(telomeric repeat-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979|mint:P09651|rcsb pdb:1HA1|rcsb pdb:1L3K|rcsb pdb:1PGZ|rcsb pdb:1PO6|rcsb pdb:1U1K|rcsb pdb:1U1L|rcsb pdb:1U1M|rcsb pdb:1U1N|rcsb pdb:1U1O|rcsb pdb:1U1P|rcsb pdb:1U1Q|rcsb pdb:1U1R|rcsb pdb:1UP1|rcsb pdb:2H4M|refseq:XP_005268883.1|dip:DIP-29338N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:ECXjsLRVtNc/aOw90tEFxowHc6c9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P14618	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q6PKG0	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1052114|uniprotkb:O94836|uniprotkb:Q8N4M2|uniprotkb:Q8NB73|uniprotkb:Q9UFD7|ensembl:ENSP00000428589	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:larp1_human(display_long)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:LARP1(gene name)|psi-mi:LARP1(display_short)|uniprotkb:KIAA0731(gene name synonym)|uniprotkb:LARP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_056130.2|ensembl:ENST00000336314|ensembl:ENSP00000336721|ensembl:ENSP00000428589|refseq:XP_005268461.1|ensembl:ENSG00000155506(gene)|ensembl:ENST00000518297(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|mint:Q6PKG0|rcsb pdb:4ZC4|rcsb pdb:5C0V|rcsb pdb:5V4R|rcsb pdb:5V7C|rcsb pdb:5V87|rcsb pdb:6PW3	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:TjQrZVRN3opAdFIWZtaEopFZf8I9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P12277	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-357706|uniprotkb:Q2LE07|uniprotkb:A8K236|uniprotkb:B2R5R4|uniprotkb:Q6FG40|uniprotkb:Q9UC66|ensembl:ENSP00000299198	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:kcrb_human(display_long)|uniprotkb:CKB(gene name)|psi-mi:CKB(display_short)|uniprotkb:CKBB(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:Brain creatine kinase(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001814.2|go:"GO:0005829"(cytosol)|ensembl:ENSG00000166165(gene)|ensembl:ENST00000348956(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12277|rcsb pdb:3B6R|rcsb pdb:3DRB|rcsb pdb:3DRE|rcsb pdb:6V9H|go:"GO:0021762"(substantia nigra development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046314"(phosphocreatine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-71288|reactome:R-HSA-9696264|dip:DIP-52968N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:WLRnU8sRUfJQoaPY0edGi9xiR+g9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P06733	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P07900	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P08238	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:wOsW7C10v2oMsM+REE38K6PAan09606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q13310	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-372844|uniprotkb:Q6P0N3|uniprotkb:B1ANQ8|ensembl:ENSP00000361948|intact:EBI-877641|uniprotkb:Q4VC03	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pabp4_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:APP1(gene name synonym)|uniprotkb:PABP4(gene name synonym)|uniprotkb:"Inducible poly(A)-binding protein"(gene name synonym)|uniprotkb:Activated-platelet protein 1(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_001129126.1|refseq:NP_003810.1|ensembl:ENSG00000090621(gene)|ensembl:ENST00000372857(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006412"(translation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061515"(myeloid cell development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q13310|refseq:NP_001129125.1	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:u1qCM3o5X7jLIa1vyqFCIH7v01w9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P11940	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-81531|intact:EBI-28983164|ensembl:ENSP00000313007|ensembl:ENSP00000428749|ensembl:ENSP00000428840|ensembl:ENSP00000429119|ensembl:ENSP00000429790|ensembl:ENSP00000429892|ensembl:ENSP00000430012|uniprotkb:Q15097|uniprotkb:Q93004	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:pabp1_human(display_long)|uniprotkb:PABPC1(gene name)|psi-mi:PABPC1(display_short)|uniprotkb:PAB1(gene name synonym)|uniprotkb:PABP1(gene name synonym)|uniprotkb:PABPC2(gene name synonym)|uniprotkb:PABP(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P11940|rcsb pdb:1CVJ|rcsb pdb:1G9L|rcsb pdb:1JGN|rcsb pdb:1JH4|rcsb pdb:2K8G|rcsb pdb:2RQG|rcsb pdb:2RQH|rcsb pdb:2X04|rcsb pdb:3KTP|rcsb pdb:3KTR|rcsb pdb:3KUI|rcsb pdb:3KUJ|rcsb pdb:3KUR|rcsb pdb:3KUS|rcsb pdb:3KUT|rcsb pdb:3PKN|interpro:IPR003954(RNA recognition, region 1)|rcsb pdb:3PTH|rcsb pdb:4F02|rcsb pdb:4F25|rcsb pdb:4F26|ensembl:ENSG00000070756(gene)|ensembl:ENST00000318607(transcript)|ensembl:ENST00000520142(transcript)|ensembl:ENST00000520804(transcript)|ensembl:ENST00000521865(transcript)|ensembl:ENST00000522658(transcript)|ensembl:ENST00000522720(transcript)|ensembl:ENST00000523555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0005737"(cytoplasm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0048255"(mRNA stabilization)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008494"(translation activator activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|rcsb pdb:5DX1|refseq:NP_002559.2|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5LGP|rcsb pdb:5LGQ|rcsb pdb:5LGR|rcsb pdb:5LGS|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-450408|reactome:R-HSA-72649|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSP00000313007|ensembl:ENSP00000430012|ensembl:ENSP00000428749|ensembl:ENSP00000429119|ensembl:ENSP00000428840|ensembl:ENSP00000429790|ensembl:ENSP00000429892|refseq:XP_005250918.1|dip:DIP-31613N	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:XudTSPq2h9ckKAc48X88RVafPRU9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:P04406	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:1314"(proximity-dependent biotin identification)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-26957435|imex:IM-28889-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:ST1 F6A F6B|comment:"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins."|comment:there is a large unexplained difference in interactor numbers between ST1 and Figure 6 results.|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2021/02/19	2021/04/28	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:88YyYmsPUkGDTh8qlM6Vlo2GFHI	false	fusion protein:c-c|flag tag:c-c|mutation with complex effect:280-280	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q99608	uniprotkb:Q9BPZ3	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-2957445|intact:EBI-28983240|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|uniprotkb:B2RBI1|uniprotkb:Q49A06|uniprotkb:Q9P0Q8|uniprotkb:Q9H0Y5|uniprotkb:D3DQC6	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:paip2_human(display_long)|uniprotkb:PAIP2(gene name)|psi-mi:PAIP2(display_short)|uniprotkb:PAIP2A(gene name synonym)|uniprotkb:HSPC218(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955135|imex:IM-28889-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	ensembl:ENSG00000120727(gene)|ensembl:ENST00000394795(transcript)|ensembl:ENST00000510080(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007613"(memory)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030371"(translation repressor activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR040396|mint:Q9BPZ3|rcsb pdb:1JGN|rcsb pdb:3KUS|rcsb pdb:3KUT|ensembl:ENST00000265192(transcript)|refseq:NP_001028284.1|refseq:NP_057564.3|refseq:XP_011541730.1|ensembl:ENSP00000265192|ensembl:ENSP00000378275|ensembl:ENSP00000422508|refseq:XP_016865011.1|refseq:XP_016865012.1	-	-	-	figure legend:f3|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:g8odIyznsg186nI0YTU30fzY+yQ9606	rigid:K5VDgjUDaggFPaFRP0xNK+LR1Yg	false	flag tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99608	uniprotkb:Q9Y6B2	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-1049975|uniprotkb:Q8N7I4|uniprotkb:Q9BZT9|uniprotkb:B2RD11|ensembl:ENSP00000431162	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:eid1_human(display_long)|uniprotkb:EID1(gene name)|psi-mi:EID1(display_short)|uniprotkb:C15orf3(gene name synonym)|uniprotkb:CRI1(gene name synonym)|uniprotkb:RBP21(gene name synonym)|uniprotkb:PNAS-22(orf name)|uniprotkb:PTD014(orf name)|uniprotkb:E1A-like inhibitor of differentiation 1(gene name synonym)|uniprotkb:CREBBP/EP300 inhibitory protein 1(gene name synonym)|uniprotkb:21 kDa pRb-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955143|imex:IM-28889-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_055150.1|ensembl:ENSG00000255302(gene)|ensembl:ENST00000530028(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0030154"(cell differentiation)|go:"GO:0035034"(histone acetyltransferase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR033255|interpro:IPR033258|mint:Q9Y6B2|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	-	-	-	figure legend:f3|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:VPSCn0cgSMX+Pl+QwutWWqZseLQ9606	rigid:qjsLWk2+arLFqBvUHSp60sSZL1Y	false	flag tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955231|imex:IM-28889-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:sf1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:T7Tk4x18oQ7+AaN4/wuOj2g16rg	false	xpress tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99608	uniprotkb:Q96A49	intact:EBI-718177|uniprotkb:B2R6Z5|ensembl:ENSP00000497916	intact:EBI-10770179|uniprotkb:Q68CP1|uniprotkb:Q96C60|uniprotkb:Q96JQ6|uniprotkb:Q96T20|ensembl:ENSP00000369500	psi-mi:necd_human(display_long)|uniprotkb:NDN(gene name)|psi-mi:NDN(display_short)	psi-mi:syap1_human(display_long)|uniprotkb:SYAP1(gene name)|psi-mi:SYAP1(display_short)|uniprotkb:BSD domain-containing signal transducer and Akt interactor protein(gene name synonym)|uniprotkb:PRO3113(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sanderson et al. (2020)	imex:IM-28889|pubmed:32529326	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26955239|imex:IM-28889-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002478.1|ensembl:ENSG00000182636(gene)|ensembl:ENST00000649030(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003016"(respiratory system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042995"(cell projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048675"(axon extension)|go:"GO:0048871"(multicellular organismal homeostasis)|go:"GO:0071514"(genomic imprinting)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR002190(MAGE protein)|interpro:IPR030086|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|reactome:R-HSA-6785807|go:"GO:0008347"(glial cell migration)	refseq:NP_116185.2|go:"GO:0030426"(growth cone)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043204"(perikaryon)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR005607(BSD)|interpro:IPR035925|rcsb pdb:1X3A|ensembl:ENSG00000169895(gene)|ensembl:ENST00000380155(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)	-	-	-	figure legend:sf1|dataset:Brain Disease - Neurological Diseases & Disorders|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/19	2021/04/16	rogid:8hFkLGNpSu6jmbrqmJuxNBZoWTs9606	rogid:+gHfLl7YaR8geuci2/cAYP8CiKA9606	rigid:T7Tk4x18oQ7+AaN4/wuOj2g16rg	false	xpress tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)