#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97924-5	uniprotkb:Q62765	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	-	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:Q62888	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7281302|intact:MINT-1891708	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn2_rat(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	interpro:IPR030023|rgd:621118|refseq:NP_446444.1|interpro:IPR019819|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|go:"GO:0001966"(thigmotaxis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|interpro:IPR029058|rcsb pdb:5V5V|reactome:R-RNO-6794361	-	-	comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:HlzMKXRXR/YD08sdzWZiyGs2g6A10116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:Q62889	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7414707|intact:MINT-1561818	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn3_rat(display_long)|uniprotkb:Nlgn3(gene name)|psi-mi:Nlgn3(display_short)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	interpro:IPR030024|refseq:NP_599163.2|rgd:621119|interpro:IPR019819|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR029058|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|reactome:R-RNO-6794361	-	-	comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:URSvzLIYVqDPAFwuhpcMmU/IH5E10116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:Q08163	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-918234|uniprotkb:Q5FVS8|ensembl:ENSRNOP00000018711	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:cap1_rat(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)|uniprotkb:Mch1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:620309|refseq:NP_071778.2|refseq:XP_006238892.1|refseq:XP_006238893.1|refseq:XP_006238894.1|dip:DIP-225N|ensembl:ENSRNOG00000013492(gene)|ensembl:ENSRNOT00000018711(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|reactome:R-RNO-6798695	-	-	-	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:2mFV6WgWfM0TAfanYPuxwvWGbvE10116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:Q7TT49	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-692673|uniprotkb:O54875|ensembl:ENSRNOP00000036487	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:mrckb_rat(display_long)|uniprotkb:CDC42-binding protein kinase beta(gene name synonym)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase beta(gene name synonym)|uniprotkb:DMPK-like beta(gene name synonym)|uniprotkb:Cdc42bpb(gene name)|psi-mi:Cdc42bpb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621753|refseq:NP_446072.2|ensembl:ENSRNOG00000009675(gene)|ensembl:ENSRNOT00000039059(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR031597|interpro:IPR033232|interpro:IPR042718|reactome:R-RNO-9013148|reactome:R-RNO-9013406	-	-	-	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:4+S7E3vqIiZE9w8fUoRrzu0mHxw10116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:O54874	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-689253	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:mrcka_rat(display_long)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase alpha(gene name synonym)|uniprotkb:Cdc42bpa(gene name)|psi-mi:Cdc42bpa(display_short)|uniprotkb:Pk428(gene name synonym)|uniprotkb:CDC42-binding protein kinase alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961224|imex:IM-28901-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621406|refseq:NP_446109.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR031597|rcsb pdb:4AW2|interpro:IPR026611|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013406	-	-	-	figure legend:ST2 F1E F1F|comment:Not all the interactions in Supplementary Table 2 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:oq31Mwavu9Tt7QfxaQYlPf8eS9Y10116	rigid:06X75RNFobbnL41oU/dANqUzPDY	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:P29994	intact:EBI-26961238	intact:EBI-8614640|intact:MINT-5026585|uniprotkb:Q62869	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:itpr1_rat(display_long)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	go:"GO:0001666"(response to hypoxia)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0016358"(dendrite development)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:0044325"(transmembrane transporter binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|rcsb pdb:3JAV|rcsb pdb:3T8S|rcsb pdb:3UJ0|rcsb pdb:3UJ4|rcsb pdb:6MU1|rcsb pdb:6MU2|rcsb pdb:7LHE|rcsb pdb:7LHF|reactome:R-RNO-114508|reactome:R-RNO-139853|reactome:R-RNO-381676|reactome:R-RNO-418457|reactome:R-RNO-5578775|reactome:R-RNO-983695|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|refseq:NP_001257526.1|rgd:2933|mint:P29994|dip:DIP-29715N	-	-	comment:mint|function:Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:L1I4Symxn2ABLg8esgd/caebF5810116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q62950	intact:EBI-26961238	intact:EBI-7109419|ensembl:ENSRNOP00000063671|uniprotkb:P70546|intact:MINT-4051102	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:dpyl1_rat(display_long)|uniprotkb:Crmp1(gene name)|psi-mi:Crmp1(display_short)|uniprotkb:Dpysl1(gene name synonym)|uniprotkb:Collapsin response mediator protein 1(gene name synonym)|uniprotkb:Inactive dihydropyrimidinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000004781(gene)|ensembl:ENSRNOT00000065334(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007411"(axon guidance)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031005"(filamin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0048666"(neuron development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1904530"(negative regulation of actin filament binding)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030624|interpro:IPR032466|mint:Q62950|reactome:R-RNO-399956|refseq:NP_037064.1|rgd:2407	-	-	function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration|comment:mint	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:7low1NeCgJsFO6tv/Jic3nBec4g10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q80WE1	intact:EBI-26961238	intact:EBI-9527133|uniprotkb:P70568	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:fmr1_rat(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	interpro:IPR041560|interpro:IPR032196|interpro:IPR040148|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|refseq:NP_434691.1|refseq:XP_006229594.1|rgd:2623|interpro:IPR040472|interpro:IPR036612|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0032797"(SMN complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0016020"(membrane)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904009"(cellular response to monosodium glutamate)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:47tPaoemgcYvnAonTwwUC9HFp/I10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q920J3	intact:EBI-26961238	intact:EBI-26961416|ensembl:ENSRNOP00000019759|ensembl:ENSRNOP00000075615|uniprotkb:Q4G087	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:coro6_rat(display_long)|uniprotkb:Coro6(gene name)|psi-mi:Coro6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000014496(gene)|ensembl:ENSRNOT00000019759(transcript)|ensembl:ENSRNOT00000086706(transcript)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027337|interpro:IPR036322|refseq:NP_620815.2|refseq:XP_006246947.1|rgd:708560	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:RU+Y1YvtXeqrh+AO96AJuZrOE5Y10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:O35412	intact:EBI-26961238	intact:EBI-26961377	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:si1l1_rat(display_long)|uniprotkb:Sipa1l1(gene name)|psi-mi:Sipa1l1(display_short)|uniprotkb:Spa1(gene name synonym)|uniprotkb:SPA-1-like protein p1294(gene name synonym)|uniprotkb:Spine-associated Rap GTPase-activating protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|refseq:NP_647546.1|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|interpro:IPR035974|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR030770|interpro:IPR021818|rgd:708497	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:vvvVMbBpiEBeGLDnIlf3HHcwcKc10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q2IBD4	intact:EBI-26961238	intact:EBI-26961354|ensembl:ENSRNOP00000072761|uniprotkb:O88864	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:cttb2_rat(display_long)|uniprotkb:Cttnbp2(gene name)|psi-mi:Cttnbp2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000061845(gene)|ensembl:ENSRNOT00000087167(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR002110(Ankyrin)|interpro:IPR019131|interpro:IPR020683|interpro:IPR036770|refseq:NP_001107873.1|rgd:628691	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:gBa5vWuVYKVZr5J0soAt9lyd2OI10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:P63144	intact:EBI-26961238	intact:EBI-26961305|ensembl:ENSRNOP00000072289|uniprotkb:P97380|uniprotkb:Q5FWS9|uniprotkb:Q61763|uniprotkb:Q63277	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:kcab1_rat(display_long)|uniprotkb:Kcnab1(gene name)|psi-mi:Kcnab1(display_short)|uniprotkb:Kvb1(gene name synonym)|uniprotkb:"K(+) channel subunit beta-1"(gene name synonym)|uniprotkb:Kv-beta-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000056697(gene)|ensembl:ENSRNOT00000077973(transcript)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007611"(learning or memory)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0060539"(diaphragm development)|go:"GO:0070402"(NADPH binding)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903817"(negative regulation of voltage-gated potassium channel activity)|go:"GO:1990635"(proximal dendrite)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005400(Potassium channel, voltage-dependent, beta subunit, KCNAB1)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|reactome:R-RNO-1296072|refseq:NP_058999.1|rgd:61827	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:nTxUOJG0MgG6ZmkYXCQgqjVFLEs10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:P05696	intact:EBI-26961238	intact:EBI-935801	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:kpca_rat(display_long)|uniprotkb:Prkca(gene name)|psi-mi:Prkca(display_short)|uniprotkb:Pkca(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	interpro:IPR017892|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rgd:3395|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034663|mint:P05696|interpro:IPR035892|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001525"(angiogenesis)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002159"(desmosome assembly)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000707"(positive regulation of dense core granule biogenesis)|rcsb pdb:1DSY|rcsb pdb:2NCE|rcsb pdb:3GPE|rcsb pdb:3RDJ|rcsb pdb:3TWY|rcsb pdb:4L1L|rcsb pdb:5W4S|reactome:R-RNO-111933|reactome:R-RNO-114516|reactome:R-RNO-1250196|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-2179392|reactome:R-RNO-3000170|reactome:R-RNO-399997|reactome:R-RNO-416993|reactome:R-RNO-4419969|reactome:R-RNO-450520|reactome:R-RNO-5099900|reactome:R-RNO-5218921|reactome:R-RNO-5668599|reactome:R-RNO-76005|reactome:R-RNO-8853659	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:wWfVnOun9EFrE7DtrG8RRwPIpLs10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q9Z2X5	intact:EBI-26961238	intact:EBI-920352|ensembl:ENSRNOP00000027428	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:home3_rat(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)|uniprotkb:Vesl3(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	rgd:620706|refseq:NP_445762.1|refseq:XP_006252953.1|ensembl:ENSRNOG00000020229(gene)|ensembl:ENSRNOT00000027428(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2X5|reactome:R-RNO-6794361	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:pJzod+zFtQHxU0N93UNrPzWttIU10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:O08875	intact:EBI-26961238	intact:EBI-26439688|ensembl:ENSRNOP00000019748	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:dclk1_rat(display_long)|uniprotkb:Dclk1(gene name)|psi-mi:Dclk1(display_short)|uniprotkb:Cpg16(gene name synonym)|uniprotkb:Dcamkl1(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent protein kinase type I-like CPG16(gene name synonym)|uniprotkb:Doublecortin-like and CAM kinase-like 1(gene name synonym)|uniprotkb:Doublecortin-like kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000032922(gene)|ensembl:ENSRNOT00000019748(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O08875|refseq:NP_445795.1|rgd:68437	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:Al+f+qhV/hs3YZhZv7GEdSNfDQM10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:P47709	intact:EBI-26961238	intact:EBI-1027524	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:rp3a_rat(display_long)|uniprotkb:Rph3a(gene name)|psi-mi:Rph3a(display_short)|uniprotkb:Exophilin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008430"(selenium binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098981"(cholinergic synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:1ZBD|rcsb pdb:2CHD|rcsb pdb:2CM5|rcsb pdb:2CM6|rcsb pdb:3RPB|rcsb pdb:4LT7|rcsb pdb:4NP9|rcsb pdb:4NS0|rcsb pdb:5LO8|rcsb pdb:5LOB|rcsb pdb:5LOW|rgd:620073|refseq:NP_598202.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR001565(Synaptotagmin)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028698|mint:P47709|interpro:IPR035892|interpro:IPR041282|interpro:IPR043566	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:riq0dOgXETaODPbUSvUER63L6jU10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q62951	intact:EBI-26961238	intact:EBI-2255842	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:dpyl4_rat(display_long)|uniprotkb:Dpysl4(gene name)|psi-mi:Dpysl4(display_short)|uniprotkb:Crmp3(gene name synonym)|uniprotkb:Ulip4(gene name synonym)|uniprotkb:Collapsin response mediator protein 3(gene name synonym)|uniprotkb:UNC33-like phosphoprotein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	rgd:2409|refseq:NP_037065.1|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011778(D-hydantoinase)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR030612|interpro:IPR032466|mint:Q62951|go:"GO:0005737"(cytoplasm)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0031005"(filamin binding)|go:"GO:0048666"(neuron development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070997"(neuron death)|go:"GO:0097485"(neuron projection guidance)|reactome:R-RNO-399956	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:ySgRvgBp8dBBZebavSjeW9O6MT010116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:F1M0Z1	uniprotkb:Q1HCL7	intact:EBI-26961238	intact:EBI-26961282|ensembl:ENSRNOP00000074419|uniprotkb:Q3B8P3	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:nakd2_rat(display_long)|uniprotkb:Nadk2(gene name)|psi-mi:Nadk2(display_short)|uniprotkb:Mnadk(gene name synonym)|uniprotkb:Nadkd1(gene name synonym)|uniprotkb:Mitochondrial NAD kinase(gene name synonym)|uniprotkb:NAD kinase domain-containing protein 1, mitochondrial(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961439|imex:IM-28901-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	ensembl:ENSRNOG00000054157(gene)|ensembl:ENSRNOT00000083799(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR002504(ATP-NAD/AcoX kinase)|interpro:IPR012355(ATP-NAD kinase-like, eukaryotic)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|reactome:R-RNO-196807|refseq:NP_001037717.1|rgd:1306809	-	-	-	figure legend:ST1 F1E SF1F|comment:Not all the interactions in Supplementary Table 1 were annotated because high-confidence datasets were not available. Only those interactors highlighted by the authors have been recorded in the entry.|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:LMo6FNLIlatFEIOBu9YGFVNIJ3k10116	rigid:iPJOB5M0as4nPb2Ce7hGS7f6rag	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97924-5	uniprotkb:Q62765	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961566|imex:IM-28901-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	-	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	figure legend:F2C|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rigid:YDKEFEB1Vz4npeqKGUSd6FrFtGs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:P19490	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-371642	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:gria1_rat(display_long)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961566|imex:IM-28901-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621531|refseq:NP_113796.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044297"(cell body)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060992"(response to fungicide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071418"(cellular response to amine stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:2AWW|rcsb pdb:2G2L|rcsb pdb:3SAJ|go:"GO:0097060"(synaptic membrane)|rcsb pdb:6NJL|rcsb pdb:6NJN|rcsb pdb:6QKC|rcsb pdb:6QKZ|rcsb pdb:7OCA|rcsb pdb:7OCC|rcsb pdb:7OCD|rcsb pdb:7OCE|rcsb pdb:7OCF|reactome:R-RNO-204005|reactome:R-RNO-399710|reactome:R-RNO-399719|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|reactome:R-RNO-438066|reactome:R-RNO-5694530|reactome:R-RNO-8849932|reactome:R-RNO-416993|mint:P19490|dip:DIP-30929N	-	-	-	figure legend:F2C|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:Bdkl7msqLXWZxd8172jZFghg6BI10116	rigid:YDKEFEB1Vz4npeqKGUSd6FrFtGs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q00960	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-396905|uniprotkb:Q62684	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nmde2_rat(display_long)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961566|imex:IM-28901-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:2738|refseq:NP_036706.1|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051707"(response to other organism)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060992"(response to fungicide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010350"(cellular response to magnesium starvation)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034097"(response to cytokine)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904644"(cellular response to curcumin)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|rcsb pdb:3JPW|rcsb pdb:3JPY|rcsb pdb:3QEL|rcsb pdb:3QEM|rcsb pdb:4PE5|rcsb pdb:5B3J|rcsb pdb:5FXG|rcsb pdb:5FXH|rcsb pdb:5FXI|rcsb pdb:5FXJ|rcsb pdb:5FXK|rcsb pdb:5TPZ|rcsb pdb:6CNA|rcsb pdb:6E7R|rcsb pdb:6E7S|rcsb pdb:6E7T|rcsb pdb:6E7U|rcsb pdb:6E7V|rcsb pdb:6E7W|rcsb pdb:6E7X|rcsb pdb:6WHR|rcsb pdb:6WHS|rcsb pdb:6WHT|rcsb pdb:6WHU|rcsb pdb:6WHV|rcsb pdb:6WHW|rcsb pdb:6WHX|rcsb pdb:6WHY|rcsb pdb:6WI0|rcsb pdb:6WI1|reactome:R-RNO-3928662|reactome:R-RNO-438066|reactome:R-RNO-5673001|reactome:R-RNO-8849932|reactome:R-RNO-9609736|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|mint:Q00960|dip:DIP-33702N	-	-	-	figure legend:F2C|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:dbOLObdhW/ts7GuZ0k8UIII99m010116	rigid:YDKEFEB1Vz4npeqKGUSd6FrFtGs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q00959	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-630970|uniprotkb:O08948|uniprotkb:Q63728	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nmde1_rat(display_long)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961566|imex:IM-28901-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:2737|refseq:NP_036705.3|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009611"(response to wounding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021510"(spinal cord development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0019901"(protein kinase binding)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|rcsb pdb:2A5S|rcsb pdb:2A5T|rcsb pdb:4JWX|rcsb pdb:4NF4|rcsb pdb:4NF5|rcsb pdb:4NF6|rcsb pdb:4NF8|rcsb pdb:5DEX|rcsb pdb:5I56|rcsb pdb:5I57|rcsb pdb:5I58|rcsb pdb:5I59|rcsb pdb:5JTY|rcsb pdb:5TPW|rcsb pdb:5TQ0|rcsb pdb:5TQ2|rcsb pdb:5U8C|rcsb pdb:5VIH|rcsb pdb:5VII|rcsb pdb:5VIJ|rcsb pdb:6MM9|rcsb pdb:6MMA|rcsb pdb:6MMB|rcsb pdb:6MMG|rcsb pdb:6MMH|rcsb pdb:6MMI|rcsb pdb:6MMJ|rcsb pdb:6MMK|rcsb pdb:6MML|rcsb pdb:6MMM|rcsb pdb:6MMN|rcsb pdb:6MMP|rcsb pdb:6MMR|rcsb pdb:6MMS|rcsb pdb:6MMT|rcsb pdb:6MMU|rcsb pdb:6MMV|rcsb pdb:6MMW|rcsb pdb:6MMX|rcsb pdb:6ODL|rcsb pdb:6OVD|rcsb pdb:6OVE|rcsb pdb:6USU|rcsb pdb:6USV|rcsb pdb:6UZ6|rcsb pdb:6UZG|rcsb pdb:6UZR|rcsb pdb:6UZW|rcsb pdb:6UZX|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051707"(response to other organism)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0060992"(response to fungicide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|dip:DIP-34031N|reactome:R-RNO-438066|reactome:R-RNO-8849932|reactome:R-RNO-9609736	-	-	-	figure legend:F2C|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:zYnLjzOSp/wEOjcHJum+QAoQxDI10116	rigid:YDKEFEB1Vz4npeqKGUSd6FrFtGs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1M0Z1	uniprotkb:Q62765	intact:EBI-26961238	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961573|imex:IM-28901-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	-	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	figure legend:F2D|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/07/06	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rigid:Yrtym+tp1MtV4T3G549BwbT2kLg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1M0Z1	uniprotkb:P47942	intact:EBI-26961238	intact:EBI-917570|intact:EBI-6096016|ensembl:ENSRNOP00000012996	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:dpyl2_rat(display_long)|uniprotkb:Turned on after division 64 kDa protein(gene name synonym)|uniprotkb:Collapsin response mediator protein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961573|imex:IM-28901-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	rgd:2517|refseq:NP_001099187.1|ensembl:ENSRNOG00000009625(gene)|ensembl:ENSRNOT00000012996(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:P47942|reactome:R-RNO-399956|reactome:R-RNO-437239	-	-	-	figure legend:F2D|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/07/06	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010116	rigid:Yrtym+tp1MtV4T3G549BwbT2kLg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q62888	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7281302|intact:MINT-1891708	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn2_rat(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961593|imex:IM-28901-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	interpro:IPR030023|rgd:621118|refseq:NP_446444.1|interpro:IPR019819|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|go:"GO:0001966"(thigmotaxis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007630"(jump response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0072553"(terminal button organization)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1904034"(positive regulation of t-SNARE clustering)|go:"GO:1904862"(inhibitory synapse assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|interpro:IPR029058|rcsb pdb:5V5V|reactome:R-RNO-6794361	-	-	comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures	figure legend:SF2D|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:HlzMKXRXR/YD08sdzWZiyGs2g6A10116	rigid:lP4iZNeiGRusAW1zAEVKBs2kpKY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q62889	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7414707|intact:MINT-1561818	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn3_rat(display_long)|uniprotkb:Nlgn3(gene name)|psi-mi:Nlgn3(display_short)|uniprotkb:Gliotactin homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961593|imex:IM-28901-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	interpro:IPR030024|refseq:NP_599163.2|rgd:621119|interpro:IPR019819|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097151"(positive regulation of inhibitory postsynaptic potential)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR029058|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|reactome:R-RNO-6794361	-	-	comment:mint|function:Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system	figure legend:SF2D|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:URSvzLIYVqDPAFwuhpcMmU/IH5E10116	rigid:lP4iZNeiGRusAW1zAEVKBs2kpKY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q62765	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961593|imex:IM-28901-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	-	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	figure legend:SF2D|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rigid:lP4iZNeiGRusAW1zAEVKBs2kpKY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60229	uniprotkb:Q99K10	intact:EBI-949233|ensembl:ENSP00000353109|intact:EBI-1104807|uniprotkb:Q8TBQ5|uniprotkb:Q9NSZ4|uniprotkb:Q9Y2A5|uniprotkb:Q6ZN45|uniprotkb:A8MSI4|uniprotkb:J3QSW6|intact:EBI-3866438|uniprotkb:C9JQ37	intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200	psi-mi:kalrn_human(display_long)|uniprotkb:KALRN(gene name)|psi-mi:KALRN(display_short)|uniprotkb:DUET(gene name synonym)|uniprotkb:DUO(gene name synonym)|uniprotkb:HAPIP(gene name synonym)|uniprotkb:TRAD(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)	psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961476|imex:IM-28901-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036865|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-5687128|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|ensembl:ENSG00000160145(gene)|ensembl:ENST00000360013(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|refseq:NP_001309929.1|refseq:NP_001019831.2|refseq:NP_003938.1|refseq:NP_008995.2|refseq:NP_001309930.1|refseq:NP_001309917.1|refseq:NP_001309918.1|refseq:NP_001309923.1|refseq:NP_001309924.1|refseq:NP_001309925.1|refseq:NP_001309926.1|refseq:NP_001309927.1|refseq:NP_001309928.1	refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361	-	-	-	figure legend:F2A|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/02/19	2021/04/23	rogid:E7oPA6ps2iq0KD8jlTCm/mNQj949606	rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090	rigid:Fp0t+SFblMng6oF9jGwQtSGP/Nk	false	-	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75962	uniprotkb:Q99K10	intact:EBI-718519|uniprotkb:Q13458|uniprotkb:Q59EQ7|uniprotkb:Q6PJC9|uniprotkb:Q6ZN05|uniprotkb:Q8IWK8|uniprotkb:D3DTD1|ensembl:ENSP00000339299	intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200	psi-mi:trio_human(display_long)|uniprotkb:PTPRF-interacting protein(gene name synonym)|uniprotkb:TRIO(gene name)|psi-mi:TRIO(display_short)	psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961485|imex:IM-28901-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009049.2|refseq:XP_011512412.1|ensembl:ENSG00000038382(gene)|ensembl:ENST00000344204(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000719(Protein kinase, core)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018159|interpro:IPR028570|interpro:IPR035899|interpro:IPR036028|interpro:IPR036179|interpro:IPR036865|mint:O75962|rcsb pdb:1NTY|rcsb pdb:2NZ8|rcsb pdb:6D8Z|reactome:R-HSA-193648|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418885|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|interpro:IPR008271(Serine/threonine protein kinase, active site)|dip:DIP-37578N	refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361	-	-	-	figure legend:F2B|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/02/19	2021/04/23	rogid:d01ioB7N6ccwAkeeoGpAa9GHZN89606	rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090	rigid:Zkjii030WerxdEb2W8VXGXNAaH0	false	-	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q99K10	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961492|imex:IM-28901-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361	-	-	-	figure legend:F2H|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090	rigid:ajdwRspjy3QRVCuFGsd9lhVCMXc	false	tandem tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97924-5	uniprotkb:Q99K10	intact:EBI-26961214|ensembl:ENSRNOP00000016340	intact:EBI-775037|ensembl:ENSMUSP00000074565|ensembl:ENSMUSP00000142200	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:nlgn1_mouse(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Kiaa1070(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961524|imex:IM-28901-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	refseq:NP_619607.2|dip:DIP-32027N|ensembl:ENSMUSG00000063887(gene)|ensembl:ENSMUST00000075054(transcript)|ensembl:ENSMUST00000193603(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|rcsb pdb:3B3Q|reactome:R-MMU-6794361	-	-	-	figure legend:F2I|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/02/19	2021/04/23	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rogid:v8ZiOUF8s1yNWhimIoIUHCDdiD810090	rigid:ajdwRspjy3QRVCuFGsd9lhVCMXc	false	myc tag:n-n|sufficient binding region:20-623	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62765	uniprotkb:P97924-5	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	intact:EBI-26961214|ensembl:ENSRNOP00000016340	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:"MI:0096"(pull down)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961599|imex:IM-28901-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	-	figure legend:SF2F|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/02/19	2021/04/23	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rigid:5hsSXg0sB1nyX9xqO7lx7MFjtKk	false	-	glutathione s tranferase tag:?-?|sufficient binding region:20-159	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62765	uniprotkb:P97924-5	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	intact:EBI-26961214|ensembl:ENSRNOP00000016340	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:p97924-5(display_long)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:Delta Kalirin-7(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961585|imex:IM-28901-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	intact:EBI-1397166(isoform-parent)|ensembl:ENSRNOG00000001706(gene)|ensembl:ENSRNOT00000016340(transcript)	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	-	figure legend:SF2B|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2021/02/19	2021/04/23	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rogid:zMQ5DcsmWPDXh4SZ5WzaEx+XQf410116	rigid:5hsSXg0sB1nyX9xqO7lx7MFjtKk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62765	uniprotkb:F1M0Z1	intact:EBI-7281118|intact:MINT-1526995|ensembl:ENSRNOP00000075793	intact:EBI-26961238	psi-mi:nlgn1_rat(display_long)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short)|uniprotkb:Neuroligin I(gene name synonym)	psi-mi:trio_rat(display_long)|uniprotkb:Trio(gene name)|psi-mi:Trio(display_short)|uniprotkb:PTPRF-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Paskus et al. (2019)	pubmed:31801062|imex:IM-28901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26961589|imex:IM-28901-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621117|refseq:NP_446320.1|refseq:XP_017446075.1|refseq:XP_017446076.1|refseq:XP_017446077.1|refseq:XP_017446078.1|refseq:XP_017446079.1|refseq:XP_017446072.1|refseq:XP_017446073.1|refseq:XP_017446074.1|ensembl:ENSRNOG00000032576(gene)|ensembl:ENSRNOT00000092660(transcript)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0007416"(synapse assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032433"(filopodium tip)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048789"(cytoskeletal matrix organization at active zone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0072553"(terminal button organization)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097115"(neurexin clustering involved in presynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098698"(postsynaptic specialization assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098942"(retrograde trans-synaptic signaling by trans-synaptic protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:0099174"(regulation of presynapse organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:0140058"(neuron projection arborization)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030022|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000310"(regulation of NMDA receptor activity)|rcsb pdb:3BIW|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|rcsb pdb:3BIX|rcsb pdb:3VKF|reactome:R-RNO-6794361|dip:DIP-44832N	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0019899"(enzyme binding)|go:"GO:0042995"(cell projection)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|refseq:XP_006232152.1|reactome:R-RNO-193648|reactome:R-RNO-416476|reactome:R-RNO-416482|reactome:R-RNO-418885|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR036865|interpro:IPR035899|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR028570|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR036028|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rgd:1308360|reactome:R-RNO-8980692|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013423	-	comment:mint|function:"Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses"	-	figure legend:SF2C|dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons)	-	2021/02/19	2021/04/23	rogid:I6UajYCOkz8f+3nt2IHH2rOCby810116	rogid:qWVuQO0H74L66Y0hTgsoZW6OIBY10116	rigid:GZn/Ybf0wBDqZclz3jtv2E9QQCo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)