#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N100	uniprotkb:P15923-2	intact:EBI-11976887|ensembl:ENSP00000362777	intact:EBI-769650|ensembl:ENSP00000468487|ensembl:ENSP00000480564	psi-mi:atoh7_human(display_long)|uniprotkb:ATOH7(gene name)|psi-mi:ATOH7(display_short)|uniprotkb:ATH5(gene name synonym)|uniprotkb:BHLHA13(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 13(gene name synonym)|uniprotkb:Helix-loop-helix protein hATH-5(gene name synonym)	psi-mi:p15923-2(display_long)|uniprotkb:PAN-1(isoform synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Atac et al. (2020)	pubmed:31696227|imex:IM-29370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-27246136|imex:IM-29370-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000179774(gene)|ensembl:ENST00000373673(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003407"(neural retina development)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0021554"(optic nerve development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046983"(protein dimerization activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR032663|interpro:IPR036638|refseq:NP_660161.1	intact:EBI-769630(tfe2_human)|uniprotkb:P15923-2(isoform-parent)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000588136(transcript)|ensembl:ENST00000611869(transcript)	-	-	isoform-comment:"The bHLH domain encompassing amino acids 546 to 599 is sufficient to mediate DNA-binding and homodimerization. Combined mutagenesis of Phe-566 and Leu-569 to Asp-566 and Glu-569, mutagenesis of Lys-585 to Ala-585 or combined mutagenesis of Ile-588 and Leu-589 to Asp-588 and Glu-589 prevents DNA-binding and homodimerization. Mutagenesis of Arg-548 to Lys-548, combined mutagenesis of Arg-547 and Arg-548 to Gly-547 and Gly-548, mutagenesis of Arg-556 to Lys-556, mutagenesis of Arg-558 to Lys-558, or combined mutagenesis of Arg-556 and Arg-558 to Gly-556 and Gly-558, alter DNA-binding but not dimerization. Variant in position: 555:E->K (in AGM8, localizes normally to the nucleus, does not perform proper DNA binding, acts in a dominant-negative manner when coexpressed with wild-type) (Ref.29). Contains a phosphothreonine at position 531."	figure legend:Fig. 5C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/18	2021/11/29	rogid:ZCrD4ZUB8HVNkuQYxHndC4k4ZuY9606	rogid:MU+UKeqmtGJCUzTqelr1FdepgSY9606	rigid:1GKq1FG3ujsHwLFc70Au1rOgzE8	false	mutation disrupting interaction strength:46-46|mutation disrupting interaction strength:59-59|mutation disrupting interaction strength:59-59|mutation decreasing interaction strength:59-59|v5 tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)