#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10636	uniprotkb:P13861	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ko et al. (2019)	pubmed:31640277|imex:IM-29197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880483|imex:IM-29197-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	intact:EBI-27077190(see-also)	-	-	figure legend:Fig. 1|comment:"To determine whether GSKIP/GSK-3beta/Tau could form an assembly, co-IP assay using GFP–Tau was used to pull down GSK3beta, GSKIP, and PKA RII, as shown in Figure 1. In addition, the complex binding ability of GSKIP was a total loss in the L130P mutant form (Figure 1, right panel, line 3 in lane 3). Moreover, our data showed that PKA RII could not be pulled down by either V41P/L45P or the L130P mutant"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	rigid:aaD+qh1uZ79TiADXUb6wz8k8Xq8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10636	uniprotkb:Q9P0R6	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	intact:EBI-1052580|uniprotkb:Q9BST1|uniprotkb:Q9NWK0|uniprotkb:B3KSZ0|ensembl:ENSP00000412315|ensembl:ENSP00000450420|ensembl:ENSP00000451188|ensembl:ENSP00000451384	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:gskip_human(display_long)|uniprotkb:GSK3beta interaction protein(gene name synonym)|uniprotkb:HSPC210(orf name)|uniprotkb:GSKIP(gene name)|psi-mi:GSKIP(display_short)|uniprotkb:C14orf129(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ko et al. (2019)	pubmed:31640277|imex:IM-29197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880483|imex:IM-29197-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	refseq:NP_057556.2|refseq:NP_001258833.1|refseq:NP_001258834.1|refseq:NP_001258835.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR007967(Protein of unknown function DUF727)|interpro:IPR023231|interpro:IPR037395|rcsb pdb:1SGO|ensembl:ENSG00000100744(gene)|ensembl:ENST00000438650(transcript)|ensembl:ENST00000554182(transcript)|ensembl:ENST00000555181(transcript)|ensembl:ENST00000556095(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0019207"(kinase regulator activity)|refseq:XP_016876854.1	intact:EBI-27077190(see-also)	-	-	figure legend:Fig. 1|comment:"To determine whether GSKIP/GSK-3beta/Tau could form an assembly, co-IP assay using GFP–Tau was used to pull down GSK3beta, GSKIP, and PKA RII, as shown in Figure 1. In addition, the complex binding ability of GSKIP was a total loss in the L130P mutant form (Figure 1, right panel, line 3 in lane 3). Moreover, our data showed that PKA RII could not be pulled down by either V41P/L45P or the L130P mutant"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rogid:Uyu0JSbjadDfFdUUxycavaEj1ys9606	rigid:aaD+qh1uZ79TiADXUb6wz8k8Xq8	false	green fluorescent protein tag:?-?	ha tag:?-?|mutation with complex effect:41-41,45-45|mutation with complex effect:130-130	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10636	uniprotkb:P49841	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ko et al. (2019)	pubmed:31640277|imex:IM-29197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26880483|imex:IM-29197-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	intact:EBI-27077190(see-also)	-	-	figure legend:Fig. 1|comment:"To determine whether GSKIP/GSK-3beta/Tau could form an assembly, co-IP assay using GFP–Tau was used to pull down GSK3beta, GSKIP, and PKA RII, as shown in Figure 1. In addition, the complex binding ability of GSKIP was a total loss in the L130P mutant form (Figure 1, right panel, line 3 in lane 3). Moreover, our data showed that PKA RII could not be pulled down by either V41P/L45P or the L130P mutant"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/03/18	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rigid:aaD+qh1uZ79TiADXUb6wz8k8Xq8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49841	uniprotkb:P10636	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	intact:EBI-366182|uniprotkb:P18518|uniprotkb:Q14799|uniprotkb:Q15549|uniprotkb:Q15550|uniprotkb:Q15551|uniprotkb:Q1RMF6|uniprotkb:Q53YB1|uniprotkb:Q5CZI7|uniprotkb:Q5XWF0|uniprotkb:Q6QT54|uniprotkb:Q9UDJ3|uniprotkb:Q9UMH0|uniprotkb:Q9UQ96|ensembl:ENSP00000458742	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:tau_human(display_long)|uniprotkb:MAPT(gene name)|psi-mi:MAPT(display_short)|uniprotkb:MTBT1(gene name synonym)|uniprotkb:TAU(gene name synonym)|uniprotkb:Neurofibrillary tangle protein(gene name synonym)|uniprotkb:Paired helical filament-tau(gene name synonym)|uniprotkb:MAPTL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ko et al. (2019)	pubmed:31640277|imex:IM-29197	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-27077190|imex:IM-29197-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	refseq:NP_001116538.2|refseq:NP_001116539.1|refseq:NP_001190181.1|refseq:NP_005901.2|refseq:NP_058518.1|refseq:NP_058519.3|refseq:NP_058525.1|ensembl:ENSG00000186868(gene)|ensembl:ENST00000571987(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001774"(microglial cell activation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007416"(synapse assembly)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016072"(rRNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030673"(axolemma)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034452"(dynactin binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044297"(cell body)|go:"GO:0044304"(main axon)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048699"(generation of neurons)|go:"GO:0050808"(synapse organization)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051721"(protein phosphatase 2A binding)|rcsb pdb:4GLR|rcsb pdb:4NP8|rcsb pdb:4TQE|rcsb pdb:4Y32|rcsb pdb:4Y3B|rcsb pdb:4Y5I|rcsb pdb:5DMG|rcsb pdb:5E2V|rcsb pdb:5E2W|rcsb pdb:5HF3|rcsb pdb:5K7N|rcsb pdb:5MO3|rcsb pdb:5MP1|rcsb pdb:5MP3|rcsb pdb:5MP5|rcsb pdb:5N5A|rcsb pdb:5N5B|rcsb pdb:5NVB|rcsb pdb:5O3L|rcsb pdb:5O3O|rcsb pdb:5O3T|rcsb pdb:5V5B|rcsb pdb:5V5C|rcsb pdb:5ZIA|rcsb pdb:5ZV3|rcsb pdb:6BB4|rcsb pdb:6CVJ|rcsb pdb:6CVN|rcsb pdb:4FL5|rcsb pdb:6DC8|rcsb pdb:6DC9|rcsb pdb:6DCA|rcsb pdb:6FBW|rcsb pdb:6FI5|rcsb pdb:6GK7|rcsb pdb:6GK8|rcsb pdb:6GX5|rcsb pdb:6H06|rcsb pdb:6HRE|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902474"(positive regulation of protein localization to synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902988"(neurofibrillary tangle assembly)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1905689"(positive regulation of diacylglycerol kinase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR002955(Tau protein)|mint:P10636|rcsb pdb:1I8H|rcsb pdb:2MZ7|rcsb pdb:2ON9|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:3OVL|rcsb pdb:4E0M|rcsb pdb:4E0N|rcsb pdb:4E0O|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0072386"(plus-end-directed organelle transport along microtubule)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097386"(glial cell projection)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098930"(axonal transport)|go:"GO:0099077"(histone-dependent DNA binding)|go:"GO:0099609"(microtubule lateral binding)|rcsb pdb:6HRF|rcsb pdb:6LRA|rcsb pdb:6N4P|rcsb pdb:6NK4|rcsb pdb:6NWP|rcsb pdb:6NWQ|rcsb pdb:6ODG|rcsb pdb:6PXR|rcsb pdb:6QJH|rcsb pdb:6QJM|rcsb pdb:6QJP|rcsb pdb:6QJQ|rcsb pdb:6TJO|rcsb pdb:6TJX|rcsb pdb:6VH7|rcsb pdb:6VHA|rcsb pdb:6VHL|rcsb pdb:6VI3|rcsb pdb:6XLI|rcsb pdb:7NRQ|rcsb pdb:7NRS|rcsb pdb:7NRT|rcsb pdb:7NRV|rcsb pdb:7NRX|reactome:R-HSA-264870|reactome:R-HSA-9619483|dip:DIP-29753N	intact:EBI-26880483(see-also)	-	-	figure legend:Fig. 1|comment:"To determine whether GSKIP/GSK-3beta/Tau could form an assembly, co-IP assay using GFP–Tau was used to pull down GSK3beta, GSKIP, and PKA RII, as shown in Figure 1. In addition, the complex binding ability of GSKIP was a total loss in the L130P mutant form (Figure 1, right panel, line 3 in lane 3). Moreover, our data showed that PKA RII could not be pulled down by either V41P/L45P or the L130P mutant"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/03/18	2021/09/02	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	rogid:aAV+Xebz92GY+wGOCRnhBztR5vM9606	rigid:+aPNNCzFwJYgvNIAXjYGz/NcNxE	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)