#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A6Y878	uniprotkb:P06756	intact:EBI-27054297	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	psi-mi:a6y878_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12111(Foot-and-mouth disease virus - type A)|taxid:12111(Foot-and-mouth disease virus - type A)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054346|pdbe:5nem|pdbe:5ner|emdb:EMD-3633|imex:IM-29184-1|emdb:EMD-3632	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	-	-	-	figure legend:Figure 1A, Figure S1C, Table 1|comment:"The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala."|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:H+Q6KZaZL9/V0hAkz1ml4Ckyy4I12111	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rigid:0Yg+rrhhxX5w4Ue6PVrpss/G1TI	false	sufficient binding region:218-287	sufficient binding region:31-624|mutation:430-430	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6Y878	uniprotkb:P18564	intact:EBI-27054297	intact:EBI-2568070|uniprotkb:C9JA97|uniprotkb:B2R9W5|uniprotkb:Q0VA95|uniprotkb:Q16500|uniprotkb:Q53RG5|uniprotkb:Q53RR6|ensembl:ENSP00000283249|ensembl:ENSP00000386367	psi-mi:a6y878_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:itb6_human(display_long)|uniprotkb:ITGB6(gene name)|psi-mi:ITGB6(display_short)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12111(Foot-and-mouth disease virus - type A)|taxid:12111(Foot-and-mouth disease virus - type A)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054346|pdbe:5nem|pdbe:5ner|emdb:EMD-3633|imex:IM-29184-1|emdb:EMD-3632	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	refseq:NP_000879.2|ensembl:ENSG00000115221(gene)|ensembl:ENST00000283249(transcript)|ensembl:ENST00000409872(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043588"(skin development)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060022"(hard palate development)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0061520"(Langerhans cell differentiation)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015436(Integrin beta-6 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|rcsb pdb:1LH9|rcsb pdb:4UM8|rcsb pdb:4UM9|rcsb pdb:5FFG|interpro:IPR032695|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000178|refseq:NP_001269282.1|refseq:NP_001269284.1|refseq:NP_001269317.1|dip:DIP-59187N	-	-	-	figure legend:Figure 1A, Figure S1C, Table 1|comment:"The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala."|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:H+Q6KZaZL9/V0hAkz1ml4Ckyy4I12111	rogid:d3MdgRChCJqyDPTL1JNQ7Yn+8dg9606	rigid:0Yg+rrhhxX5w4Ue6PVrpss/G1TI	false	sufficient binding region:218-287	sufficient binding region:22-491|mutation:287-287	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6Y878	uniprotkb:Q6ZZ87	intact:EBI-27054297	intact:EBI-27054244	psi-mi:a6y878_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12111(Foot-and-mouth disease virus - type A)|taxid:12111(Foot-and-mouth disease virus - type A)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054346|pdbe:5nem|pdbe:5ner|emdb:EMD-3633|imex:IM-29184-1|emdb:EMD-3632	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1A, Figure S1C, Table 1|comment:"The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala."|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:H+Q6KZaZL9/V0hAkz1ml4Ckyy4I12111	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rigid:0Yg+rrhhxX5w4Ue6PVrpss/G1TI	false	sufficient binding region:218-287	sufficient binding region:505-724	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6Y878	uniprotkb:Q6ZZ87	intact:EBI-27054297	intact:EBI-27054244	psi-mi:a6y878_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12111(Foot-and-mouth disease virus - type A)|taxid:12111(Foot-and-mouth disease virus - type A)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054346|pdbe:5nem|pdbe:5ner|emdb:EMD-3633|imex:IM-29184-1|emdb:EMD-3632	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1A, Figure S1C, Table 1|comment:"The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala."|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:H+Q6KZaZL9/V0hAkz1ml4Ckyy4I12111	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rigid:0Yg+rrhhxX5w4Ue6PVrpss/G1TI	false	sufficient binding region:218-287	sufficient binding region:291-504	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6Y878	uniprotkb:Q98W00	intact:EBI-27054297	intact:EBI-27054228	psi-mi:a6y878_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:q98w00_9pico(display_long)|uniprotkb:1D(gene name)|psi-mi:1D(display_short)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12111(Foot-and-mouth disease virus - type A)|taxid:12111(Foot-and-mouth disease virus - type A)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054346|pdbe:5nem|pdbe:5ner|emdb:EMD-3633|imex:IM-29184-1|emdb:EMD-3632	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0039694"(viral RNA genome replication)|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR033703|interpro:IPR029053	-	-	-	figure legend:Figure 1A, Figure S1C, Table 1|comment:"The two PDB files given as cross-references differ in one position: the 5nem sequence contains a mutation compared to 5ner - Q98W00:p.Val129Ala."|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:H+Q6KZaZL9/V0hAkz1ml4Ckyy4I12111	rogid:reIuZQcMudGtJedNHbGfHAPcI1E12118	rigid:0Yg+rrhhxX5w4Ue6PVrpss/G1TI	false	sufficient binding region:218-287	sufficient binding region:1-210	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P18564	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-2568070|uniprotkb:C9JA97|uniprotkb:B2R9W5|uniprotkb:Q0VA95|uniprotkb:Q16500|uniprotkb:Q53RG5|uniprotkb:Q53RR6|ensembl:ENSP00000283249|ensembl:ENSP00000386367	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:itb6_human(display_long)|uniprotkb:ITGB6(gene name)|psi-mi:ITGB6(display_short)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054613|pdbe:5net|imex:IM-29184-3|pdbe:5neu|emdb:EMD-3634|emdb:EMD-3635	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000879.2|ensembl:ENSG00000115221(gene)|ensembl:ENST00000283249(transcript)|ensembl:ENST00000409872(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043588"(skin development)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060022"(hard palate development)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060435"(bronchiole development)|go:"GO:0061520"(Langerhans cell differentiation)|go:"GO:0070166"(enamel mineralization)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015436(Integrin beta-6 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|rcsb pdb:1LH9|rcsb pdb:4UM8|rcsb pdb:4UM9|rcsb pdb:5FFG|interpro:IPR032695|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000178|refseq:NP_001269282.1|refseq:NP_001269284.1|refseq:NP_001269317.1|dip:DIP-59187N	-	-	-	figure legend:Figure 1B, Figure S1D, Table 1|comment:"The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:d3MdgRChCJqyDPTL1JNQ7Yn+8dg9606	rigid:9isDTGf/ekODmlKuQGfVA5xFTng	false	sufficient binding region:31-624|mutation:430-430	sufficient binding region:22-491|mutation:287-287	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:Q6PMW3	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-27054523	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054613|pdbe:5net|imex:IM-29184-3|pdbe:5neu|emdb:EMD-3634|emdb:EMD-3635	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1B, Figure S1D, Table 1|comment:"The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:9isDTGf/ekODmlKuQGfVA5xFTng	false	sufficient binding region:31-624|mutation:430-430	sufficient binding region:725-932	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:Q6PMW3	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-27054523	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054613|pdbe:5net|imex:IM-29184-3|pdbe:5neu|emdb:EMD-3634|emdb:EMD-3635	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1B, Figure S1D, Table 1|comment:"The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:9isDTGf/ekODmlKuQGfVA5xFTng	false	sufficient binding region:31-624|mutation:430-430	sufficient binding region:505-724|mutation:672-672|mutation:678-678	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:Q6PMW3	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-27054523	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054613|pdbe:5net|imex:IM-29184-3|pdbe:5neu|emdb:EMD-3634|emdb:EMD-3635	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1B, Figure S1D, Table 1|comment:"The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:9isDTGf/ekODmlKuQGfVA5xFTng	false	sufficient binding region:31-624|mutation:430-430	sufficient binding region:287-504|mutation:379-379	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:Q6PMW3	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-27054523	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27054613|pdbe:5net|imex:IM-29184-3|pdbe:5neu|emdb:EMD-3634|emdb:EMD-3635	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure 1B, Figure S1D, Table 1|comment:"The sequences of the viral proteins were taken from the cross-referenced PDB files. The four segments of the capsid protein quoted in PDB are actually cleaved from a viral polyprotein. The best match to the merged sequence is Q6PMW3, region 202-932 (identified using BLAST on UniProt). The mutations specified as features express the differences between this UniProt sequence and the sequences in the PDB (and are not stated in the publication). The two PDB files given as cross-references differ in one position: the 5net sequence contains a mutation compared to 5neu - Q6PMW3:p.His560Arg."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:9isDTGf/ekODmlKuQGfVA5xFTng	false	sufficient binding region:31-624|mutation:430-430	sufficient binding region:202-286	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q7TD07	intact:EBI-27054244	intact:EBI-27056962	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q7td07_9pico(display_long)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058318|imex:IM-29184-7|pdbe:5ned|emdb:EMD-3630	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|rcsb pdb:5NE4|rcsb pdb:5NED|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Fig. S1A,|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:+vrBnhDt0KGYwynB1pB54BCQ7eA12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:202-286	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q7TD07	intact:EBI-27054244	intact:EBI-27056962	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q7td07_9pico(display_long)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058318|imex:IM-29184-7|pdbe:5ned|emdb:EMD-3630	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|rcsb pdb:5NE4|rcsb pdb:5NED|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Fig. S1A,|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:+vrBnhDt0KGYwynB1pB54BCQ7eA12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:505-724	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q98W00	intact:EBI-27054244	intact:EBI-27054228	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q98w00_9pico(display_long)|uniprotkb:1D(gene name)|psi-mi:1D(display_short)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058318|imex:IM-29184-7|pdbe:5ned|emdb:EMD-3630	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR033703|interpro:IPR029053	-	-	-	figure legend:Fig. S1A,|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:reIuZQcMudGtJedNHbGfHAPcI1E12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:1-211	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PMW3	uniprotkb:Q6PMW3	intact:EBI-27054523	intact:EBI-27054523	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058391|imex:IM-29184-9|pdbe:5nej|emdb:EMD-3631	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure S1B|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:7NnurGFyitxD/FNkRXvTqQ81qhM	false	sufficient binding region:725-932	sufficient binding region:505-724|mutation:672-672|mutation:678-678	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PMW3	uniprotkb:Q6PMW3	intact:EBI-27054523	intact:EBI-27054523	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058391|imex:IM-29184-9|pdbe:5nej|emdb:EMD-3631	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure S1B|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:7NnurGFyitxD/FNkRXvTqQ81qhM	false	sufficient binding region:725-932	sufficient binding region:287-504|mutation:379-379	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PMW3	uniprotkb:Q6PMW3	intact:EBI-27054523	intact:EBI-27054523	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:q6pmw3_9pico(display_long)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27058391|imex:IM-29184-9|pdbe:5nej|emdb:EMD-3631	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5AC9|rcsb pdb:5DDJ|rcsb pdb:5NEJ|rcsb pdb:5NET|rcsb pdb:5NEU|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Figure S1B|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/27	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rogid:RHtEHeqUHt2wq64356alcLFRYTQ12118	rigid:7NnurGFyitxD/FNkRXvTqQ81qhM	false	sufficient binding region:725-932	sufficient binding region:202-286	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q7TD07	intact:EBI-27054244	intact:EBI-27056962	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q7td07_9pico(display_long)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057011|pdbe:5ne4|imex:IM-29184-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|rcsb pdb:5NE4|rcsb pdb:5NED|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Table 2|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/30	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:+vrBnhDt0KGYwynB1pB54BCQ7eA12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:202-286	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q7TD07	intact:EBI-27054244	intact:EBI-27056962	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q7td07_9pico(display_long)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057011|pdbe:5ne4|imex:IM-29184-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|rcsb pdb:5NE4|rcsb pdb:5NED|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	-	-	-	figure legend:Table 2|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/30	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:+vrBnhDt0KGYwynB1pB54BCQ7eA12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:505-724	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZZ87	uniprotkb:Q98W00	intact:EBI-27054244	intact:EBI-27054228	psi-mi:q6zz87_9pico(display_long)|uniprotkb:polyprotein(gene name)|psi-mi:polyprotein(display_short)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Capsid protein VP4(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Genome-linked protein VPg1(gene name synonym)|uniprotkb:Genome-linked protein VPg2(gene name synonym)|uniprotkb:Genome-linked protein VPg3(gene name synonym)|uniprotkb:Leader protease(gene name synonym)|uniprotkb:P1A(gene name synonym)|uniprotkb:P1B(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:P52(gene name synonym)|uniprotkb:P56A(gene name synonym)|uniprotkb:Picornain 3C(gene name synonym)|uniprotkb:Protease 3C(gene name synonym)|uniprotkb:Protease P20B(gene name synonym)|uniprotkb:Protein 2A(gene name synonym)|uniprotkb:Protein 2C(gene name synonym)|uniprotkb:Protein 3A(gene name synonym)|uniprotkb:Protein 3B-1(gene name synonym)|uniprotkb:Protein 3B-2(gene name synonym)|uniprotkb:Protein 3B-3(gene name synonym)|uniprotkb:RNA-directed RNA polymerase 3D-POL(gene name synonym)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:VP4-VP2(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 2(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)|uniprotkb:protein 2B(gene name synonym)|uniprotkb:Virion protein 4(gene name synonym)	psi-mi:q98w00_9pico(display_long)|uniprotkb:1D(gene name)|psi-mi:1D(display_short)|uniprotkb:Capsid protein VP1(gene name synonym)|uniprotkb:Capsid protein VP3(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:P1C(gene name synonym)|uniprotkb:P1D(gene name synonym)|uniprotkb:Virion protein 1(gene name synonym)|uniprotkb:Virion protein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kotecha et al. (2017)	pubmed:28534487|imex:IM-29184	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	taxid:12118(foot-and-mouth disease virus - type o)|taxid:12118(Foot-and-mouth disease virus - type O)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27057011|pdbe:5ne4|imex:IM-29184-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006417"(regulation of translation)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR015031(Capsid protein VP4, Picornavirus)|interpro:IPR037080|interpro:IPR043502|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR038765|interpro:IPR044067|interpro:IPR008739(Peptidase C28, foot-and-mouth virus L-proteinase)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|interpro:IPR001676(Picornavirus capsid)|interpro:IPR043128|interpro:IPR033703|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR029053	go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:5NE4|rcsb pdb:5NED|rcsb pdb:5NEM|rcsb pdb:5NER|interpro:IPR004080(Foot-and-mouth disease virus VP1 coat)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR033703|interpro:IPR029053	-	-	-	figure legend:Table 2|comment:The four segments of the capsid protein listed as participants are actually cleaved from a viral polyprotein, and act as four separate proteins in interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/08/04	2021/08/30	rogid:3p8YEN1OGgFGk42wQP5NisR0iLU12118	rogid:reIuZQcMudGtJedNHbGfHAPcI1E12118	rigid:qVoefGLzZXErvikH50QUE271BPM	false	sufficient binding region:287-504	sufficient binding region:1-211	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)