#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H9E1	uniprotkb:Q7Z6Z7	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q99623	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q5T0W9	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-2556565|uniprotkb:Q96DQ2|uniprotkb:Q2M1P3|ensembl:ENSP00000304078	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:fa83b_human(display_long)|uniprotkb:C6orf143(gene name synonym)|uniprotkb:FAM83B(gene name)|psi-mi:FAM83B(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_001010872.1|refseq:XP_011512696.1|refseq:XP_011512697.1|ensembl:ENSG00000168143(gene)|ensembl:ENST00000306858(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|interpro:IPR012461(Protein of unknown function DUF1669)|rcsb pdb:5LZK|rcsb pdb:5QHI|rcsb pdb:5QHJ|rcsb pdb:5QHK|rcsb pdb:5QHL|rcsb pdb:5QHM|rcsb pdb:5QHN|rcsb pdb:5QHO|rcsb pdb:5QHP|rcsb pdb:5QHQ|rcsb pdb:5QHR|rcsb pdb:5QHS|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:XP_006715085.1|refseq:XP_016865967.1	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:WzQTBg74ImTqkPDdKRM0YVcGXPY9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q9Y5Q8	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-1045409|uniprotkb:Q8N2U7|uniprotkb:Q8N857|uniprotkb:Q96GD9|uniprotkb:Q9H4P2|uniprotkb:A6NI44|uniprotkb:A6NJB9|uniprotkb:Q5T7U2|uniprotkb:Q5T7U3|intact:EBI-2556713|ensembl:ENSP00000361169	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:tf3c5_human(display_long)|uniprotkb:Transcription factor IIIC subunit epsilon(gene name synonym)|uniprotkb:TF3C-epsilon(gene name synonym)|uniprotkb:Transcription factor IIIC 63 kDa subunit(gene name synonym)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short)|uniprotkb:CDABP0017(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_001116295.1|refseq:NP_036219.2|ensembl:ENSG00000148308(gene)|ensembl:ENST00000372097(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|mint:Q9Y5Q8|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|refseq:NP_001273638.1|dip:DIP-50823N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:Cb1wPs3qn4+Up/g7WgOMDEFtp+M9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q9UQL6	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-715576|uniprotkb:O60340|uniprotkb:O60528|uniprotkb:Q96DY4|intact:EBI-28970762|uniprotkb:C9JFV9|ensembl:ENSP00000468004|ensembl:ENSP00000507606	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:hdac5_human(display_long)|uniprotkb:Antigen NY-CO-9(gene name synonym)|uniprotkb:HDAC5(gene name)|psi-mi:HDAC5(display_short)|uniprotkb:KIAA0600(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_001015053.1|refseq:NP_005465.2|refseq:XP_005256963.1|ensembl:ENST00000225983|ensembl:ENSP00000225983|ensembl:ENST00000336057|ensembl:ENSP00000337290|ensembl:ENSP00000468004|ensembl:ENSP00000507606|dip:DIP-38260N|rcsb pdb:5UWI|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8943724|mint:Q9UQL6|ensembl:ENSG00000108840(gene)|ensembl:ENST00000586802(transcript)|ensembl:ENST00000682912(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:fI8A5VuOawGthBb/65R47AEGZ/Y9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:P32119	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-1266300|uniprotkb:P31945|uniprotkb:P32118|uniprotkb:P35701|uniprotkb:Q6FHG4|uniprotkb:Q92763|uniprotkb:Q9UC23|uniprotkb:A8K0C0|ensembl:ENSP00000301522	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:prdx2_human(display_long)|uniprotkb:PRDX2(gene name)|psi-mi:PRDX2(display_short)|uniprotkb:NKEFB(gene name synonym)|uniprotkb:TDPX1(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:PRP(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor B(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_005800.3|dip:DIP-39882N|ensembl:ENSG00000167815(gene)|ensembl:ENST00000301522(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P32119|rcsb pdb:1QMV|rcsb pdb:5B8A|rcsb pdb:5B8B|rcsb pdb:5IJT|rcsb pdb:7KIZ|rcsb pdb:7KJ0|rcsb pdb:7KJ1|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:F8+7/3HrAcJq7BjkZaig16mCOO89606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:O00287	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-3929296|uniprotkb:Q5VZM6|uniprotkb:B2R9T8|uniprotkb:Q8TC40|ensembl:ENSP00000255476	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:rfxap_human(display_long)|uniprotkb:RFXAP(gene name)|psi-mi:RFXAP(display_short)|uniprotkb:RFX DNA-binding complex 36 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	ensembl:ENSG00000133111(gene)|ensembl:ENST00000255476(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR029316|interpro:IPR038308|rcsb pdb:2KW3|refseq:NP_000529.1	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:r+XmZDak1gN3ZSNz3qypJUrb0hg9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:P11802	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:P02545	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:O75147	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q8N163	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:O94964	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-2433678|uniprotkb:A6NK10|uniprotkb:Q14DB2|uniprotkb:Q5JW51|uniprotkb:Q6ZTG8	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:soga1_human(display_long)|uniprotkb:SOGA1(gene name)|psi-mi:SOGA1(display_short)|uniprotkb:C20orf117(gene name synonym)|uniprotkb:KIAA0889(gene name synonym)|uniprotkb:SOGA(gene name synonym)|uniprotkb:SOGA family member 1(gene name synonym)|uniprotkb:Suppressor of glucose by autophagy(gene name synonym)|uniprotkb:Suppressor of glucose, autophagy-associated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_542194.2|refseq:NP_954650.2|interpro:IPR027881|interpro:IPR027882|mint:O94964|go:"GO:0005615"(extracellular space)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:m+lk89tvKyS8v/BItPtLX+XUMVU9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q13263	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q03252	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-2830427|uniprotkb:O75292|uniprotkb:Q14734|uniprotkb:Q96DF6|ensembl:ENSP00000327054|intact:EBI-11044751|intact:EBI-20728818	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:lmnb2_human(display_long)|uniprotkb:LMNB2(gene name)|psi-mi:LMNB2(display_short)|uniprotkb:LMN2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	ensembl:ENSG00000176619(gene)|ensembl:ENST00000325327(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:Q03252|rcsb pdb:2LLL|rcsb pdb:5BNW|refseq:NP_116126.3|dip:DIP-57724N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:Jt7rEo5Br8HidU+VAc0L6rtBU889606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q14999	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q96JM2	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-1210359|uniprotkb:Q8N408|uniprotkb:Q5T0T4|intact:EBI-28975500|ensembl:ENSP00000277225	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:zn462_human(display_long)|uniprotkb:ZNF462(gene name)|psi-mi:ZNF462(display_short)|uniprotkb:KIAA1803(gene name synonym)|uniprotkb:Zinc finger PBX1-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_067047.4|ensembl:ENSP00000277225|ensembl:ENST00000441147|ensembl:ENSP00000397306|refseq:XP_006717278.1|refseq:XP_006717279.1|dip:DIP-39340N|ensembl:ENSG00000148143(gene)|ensembl:ENST00000277225(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q96JM2|rcsb pdb:1X6F	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:ftIOu4wVkBWJw+4aHw+R+nN44Vc9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:P48382	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-923266|uniprotkb:Q5VWC3|uniprotkb:D3DV19|uniprotkb:B7Z848|uniprotkb:E9PFU4|ensembl:ENSP00000290524|ensembl:ENSP00000357864|ensembl:ENSP00000389130	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:rfx5_human(display_long)|uniprotkb:RFX5(gene name)|psi-mi:RFX5(display_short)|uniprotkb:Regulatory factor X 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_000440.1|refseq:NP_001020774.1|refseq:XP_005245462.1|refseq:XP_005245463.1|refseq:XP_011508149.1|refseq:XP_011508150.1|refseq:XP_011508151.1|refseq:XP_011508152.1|ensembl:ENSG00000143390(gene)|ensembl:ENST00000290524(transcript)|ensembl:ENST00000368870(transcript)|ensembl:ENST00000452671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR029298|interpro:IPR033486|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|interpro:IPR040889|mint:P48382|rcsb pdb:2KW3|rcsb pdb:3V30|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:kElLakR+ct4K8Mw6q91im3K8Zh89606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q9H0W5	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H9E1	uniprotkb:Q2KHR2	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-1222187|uniprotkb:Q6ZRR1|uniprotkb:Q6ZTY6|uniprotkb:Q8N3J0|uniprotkb:Q9H7A9|uniprotkb:Q9H956|ensembl:ENSP00000501248|ensembl:ENSP00000501278	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:rfx7_human(display_long)|uniprotkb:RFXDC2(gene name synonym)|uniprotkb:Regulatory factor X 7(gene name synonym)|uniprotkb:Regulatory factor X domain-containing protein 2(gene name synonym)|uniprotkb:RFX7(gene name)|psi-mi:RFX7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656693|imex:IM-28747-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_073752.5|refseq:XP_011520227.1|refseq:XP_016877996.1|refseq:XP_016877997.1|ensembl:ENSG00000181827(gene)|ensembl:ENST00000673997(transcript)|ensembl:ENST00000674082(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|rcsb pdb:4QQI|rcsb pdb:6MEW	-	-	-	figure legend:Fig. 1B, Supp. Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:rs7zpZEFUplmE+r8TgFcmQ9LYrU9606	rigid:MFjD959piMc/aRbIPFNcZ1iJ+j4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q7Z6Z7	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q9H0W5	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q13263	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:P31645	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:P11441	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:euKOrDRC1mx0s2QVY95010PRaIg9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:O15085	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-311099|intact:EBI-28988539|ensembl:ENSP00000354644|uniprotkb:Q5VY40|uniprotkb:D3DVD0|uniprotkb:Q6PFW2	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:arhgb_human(display_long)|uniprotkb:ARHGEF11(gene name)|psi-mi:ARHGEF11(display_short)|uniprotkb:KIAA0380(gene name synonym)|uniprotkb:PDZ-RhoGEF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	ensembl:ENSG00000132694(gene)|ensembl:ENST00000361409(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_055599.1|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|rcsb pdb:1HTJ|rcsb pdb:1XCG|rcsb pdb:2DLS|rcsb pdb:3KZ1|rcsb pdb:3T06|rcsb pdb:5E6P|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5TYT|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_937879.1|ensembl:ENSP00000354644|ensembl:ENST00000368194|ensembl:ENSP00000357177|dip:DIP-31622N	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:1xhgHWC/U14RFSWNJmZudD2/DdQ9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:A0JNW5	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-2850901|uniprotkb:Q8NDL1|uniprotkb:O75183|uniprotkb:Q9BTS5|uniprotkb:Q9H0F1|uniprotkb:A0PJE5|uniprotkb:Q96C30|ensembl:ENSP00000279907	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:uh1bl_human(display_long)|uniprotkb:KIAA0701(gene name synonym)|uniprotkb:UHRF1BP1L(gene name)|psi-mi:UHRF1BP1L(display_short)|uniprotkb:SHIP164(gene name synonym)|uniprotkb:Syntaxin-6 Habc-interacting protein of 164 kDa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_001006948.1|refseq:NP_055869.1|ensembl:ENSG00000111647(gene)|ensembl:ENST00000279907(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0062069"(GARP complex binding)|interpro:IPR026728|interpro:IPR026854|mint:A0JNW5|reactome:R-HSA-9696270	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:237hjaOv2LiPUuNRvDZ3pPMym1Q9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q99623	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:h4pib54mBeQgOKCe/hib58LM26w9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:O00287	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-3929296|uniprotkb:Q5VZM6|uniprotkb:B2R9T8|uniprotkb:Q8TC40|ensembl:ENSP00000255476	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:rfxap_human(display_long)|uniprotkb:RFXAP(gene name)|psi-mi:RFXAP(display_short)|uniprotkb:RFX DNA-binding complex 36 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	ensembl:ENSG00000133111(gene)|ensembl:ENST00000255476(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR029316|interpro:IPR038308|rcsb pdb:2KW3|refseq:NP_000529.1	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:r+XmZDak1gN3ZSNz3qypJUrb0hg9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:P46379	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:P02545	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:O94964	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-2433678|uniprotkb:A6NK10|uniprotkb:Q14DB2|uniprotkb:Q5JW51|uniprotkb:Q6ZTG8	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:soga1_human(display_long)|uniprotkb:SOGA1(gene name)|psi-mi:SOGA1(display_short)|uniprotkb:C20orf117(gene name synonym)|uniprotkb:KIAA0889(gene name synonym)|uniprotkb:SOGA(gene name synonym)|uniprotkb:SOGA family member 1(gene name synonym)|uniprotkb:Suppressor of glucose by autophagy(gene name synonym)|uniprotkb:Suppressor of glucose, autophagy-associated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_542194.2|refseq:NP_954650.2|interpro:IPR027881|interpro:IPR027882|mint:O94964|go:"GO:0005615"(extracellular space)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0070062"(extracellular exosome)	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:m+lk89tvKyS8v/BItPtLX+XUMVU9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q03252	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-2830427|uniprotkb:O75292|uniprotkb:Q14734|uniprotkb:Q96DF6|ensembl:ENSP00000327054|intact:EBI-11044751|intact:EBI-20728818	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:lmnb2_human(display_long)|uniprotkb:LMNB2(gene name)|psi-mi:LMNB2(display_short)|uniprotkb:LMN2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	ensembl:ENSG00000176619(gene)|ensembl:ENST00000325327(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:Q03252|rcsb pdb:2LLL|rcsb pdb:5BNW|refseq:NP_116126.3|dip:DIP-57724N	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:Jt7rEo5Br8HidU+VAc0L6rtBU889606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:Q2KHR2	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-1222187|uniprotkb:Q6ZRR1|uniprotkb:Q6ZTY6|uniprotkb:Q8N3J0|uniprotkb:Q9H7A9|uniprotkb:Q9H956|ensembl:ENSP00000501248|ensembl:ENSP00000501278	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:rfx7_human(display_long)|uniprotkb:RFXDC2(gene name synonym)|uniprotkb:Regulatory factor X 7(gene name synonym)|uniprotkb:Regulatory factor X domain-containing protein 2(gene name synonym)|uniprotkb:RFX7(gene name)|psi-mi:RFX7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_073752.5|refseq:XP_011520227.1|refseq:XP_016877996.1|refseq:XP_016877997.1|ensembl:ENSG00000181827(gene)|ensembl:ENST00000673997(transcript)|ensembl:ENST00000674082(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|rcsb pdb:4QQI|rcsb pdb:6MEW	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:rs7zpZEFUplmE+r8TgFcmQ9LYrU9606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:O14593	uniprotkb:P48382	intact:EBI-1057665|uniprotkb:O95839|uniprotkb:Q6FGA8|uniprotkb:Q24JQ1|ensembl:ENSP00000305071|ensembl:ENSP00000384572	intact:EBI-923266|uniprotkb:Q5VWC3|uniprotkb:D3DV19|uniprotkb:B7Z848|uniprotkb:E9PFU4|ensembl:ENSP00000290524|ensembl:ENSP00000357864|ensembl:ENSP00000389130	psi-mi:rfxk_human(display_long)|uniprotkb:RFXANK(gene name)|psi-mi:RFXANK(display_short)|uniprotkb:ANKRA1(gene name synonym)|uniprotkb:RFXB(gene name synonym)|uniprotkb:Regulatory factor X subunit B(gene name synonym)|uniprotkb:Regulatory factor X-associated ankyrin-containing protein(gene name synonym)|uniprotkb:Ankyrin repeat family A protein 1(gene name synonym)	psi-mi:rfx5_human(display_long)|uniprotkb:RFX5(gene name)|psi-mi:RFX5(display_short)|uniprotkb:Regulatory factor X 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656719|imex:IM-28747-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003712.1|refseq:NP_604389.1|refseq:NP_001265656.1|refseq:NP_001265657.1|refseq:XP_005260191.1|refseq:XP_005260192.1|refseq:XP_016882904.1|refseq:XP_016882905.1|ensembl:ENSG00000064490(gene)|ensembl:ENST00000303088(transcript)|ensembl:ENST00000407360(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017362(DNA-binding, RFXANK)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3UXG|rcsb pdb:3V30|rcsb pdb:6MEW	refseq:NP_000440.1|refseq:NP_001020774.1|refseq:XP_005245462.1|refseq:XP_005245463.1|refseq:XP_011508149.1|refseq:XP_011508150.1|refseq:XP_011508151.1|refseq:XP_011508152.1|ensembl:ENSG00000143390(gene)|ensembl:ENST00000290524(transcript)|ensembl:ENST00000368870(transcript)|ensembl:ENST00000452671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003150(DNA-binding RFX)|interpro:IPR029298|interpro:IPR033486|interpro:IPR036388|interpro:IPR036390|interpro:IPR039779|interpro:IPR040889|mint:P48382|rcsb pdb:2KW3|rcsb pdb:3V30|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	-	-	-	figure legend:Fig. 1B, Supp. Table 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:MepZW2vO+tBA4f1UGh979gzgY9g9606	rogid:kElLakR+ct4K8Mw6q91im3K8Zh89606	rigid:vK10+qg5QOr0LamJTYZoCebTiZ8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9H0W5	uniprotkb:Q9H9E1	intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short)	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656752|imex:IM-28747-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	-	-	-	figure legend:Fig. 2B, 2C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rigid:qw/cYKuOjbFqe7UFcHL+TY1qWWM	false	flag tag:?-?|necessary binding region:349..349-538|mutation disrupting interaction strength:504-504|mutation disrupting interaction strength:503-503	green fluorescent protein tag:?-?|mutation disrupting interaction strength:188-188|mutation with no effect:31-31	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H9E1	uniprotkb:Q9H0W5	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656777|imex:IM-28747-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664	-	-	-	figure legend:Fig. 3A, 3B, 3E, 4A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	kd:0.18x10^-6(molar)	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606	rigid:qw/cYKuOjbFqe7UFcHL+TY1qWWM	false	sufficient binding region:142-313(IPR036770)	sufficient binding region:494-510|O-phospho-L-threonine:504-504	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H9E1	uniprotkb:Q9H0W5	intact:EBI-10215533|intact:EBI-28970409|ensembl:ENSP00000296785	intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158	psi-mi:anra2_human(display_long)|uniprotkb:ANKRA2(gene name)|psi-mi:ANKRA2(display_short)|uniprotkb:ANKRA(gene name synonym)|uniprotkb:RFXANK-like protein 2(gene name synonym)	psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Nie et al. (2015)	imex:IM-28747|pubmed:25752541	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26656812|wwpdb:4LG6|imex:IM-28747-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000296785|refseq:NP_075526.1|ensembl:ENSG00000164331(gene)|ensembl:ENST00000296785(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:3SO8|rcsb pdb:3V2O|rcsb pdb:3V2X|rcsb pdb:3V31|rcsb pdb:4LG6|rcsb pdb:4QQI	refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664	-	-	-	figure legend:Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2021/02/16	2021/02/16	rogid:IjOWPVJ6vB6TbYgwULJT3bqyiGs9606	rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606	rigid:qw/cYKuOjbFqe7UFcHL+TY1qWWM	false	sufficient binding region:142-313(IPR036770)	sufficient binding region:494-510	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)