#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9GZM8 uniprotkb:P63005 intact:EBI-928842|uniprotkb:Q86T80|uniprotkb:Q8TAR7|uniprotkb:Q9UH50|uniprotkb:B3KP93|intact:EBI-2557484|intact:EBI-11041407|uniprotkb:D3DTS0|uniprotkb:J3QT32|ensembl:ENSP00000333982 intact:EBI-917499|uniprotkb:O35592|uniprotkb:P43035|uniprotkb:P81692|uniprotkb:Q9R2A6|ensembl:ENSMUSP00000021091|ensembl:ENSMUSP00000099578 psi-mi:ndel1_human(display_long)|uniprotkb:NDEL1(gene name)|psi-mi:NDEL1(display_short)|uniprotkb:Mitosin-associated protein 1(gene name synonym)|uniprotkb:EOPA(gene name synonym)|uniprotkb:MITAP1(gene name synonym)|uniprotkb:NUDEL(gene name synonym) psi-mi:lis1_mouse(display_long)|uniprotkb:PAF acetylhydrolase 45 kDa subunit(gene name synonym)|uniprotkb:PAF-AH alpha(gene name synonym)|uniprotkb:Lissencephaly-1 protein(gene name synonym)|uniprotkb:Pafah1b1(gene name)|psi-mi:Pafah1b1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:Lis-1(gene name synonym)|uniprotkb:Pafaha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pandey et al. (2011) pubmed:22114287|imex:IM-29102 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27039250|imex:IM-29102-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110435.1|refseq:NP_001020750.1|refseq:XP_016880674.1|refseq:XP_016880676.1|dip:DIP-29554N|ensembl:ENSG00000166579(gene)|ensembl:ENST00000334527(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032418"(lysosome localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043203"(axon hillock)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060053"(neurofilament cytoskeleton)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033493|interpro:IPR033494|mint:Q9GZM8|rcsb pdb:2V66|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025 refseq:NP_038653.1|dip:DIP-29555N|ensembl:ENSMUSG00000020745(gene)|ensembl:ENSMUST00000021091(transcript)|ensembl:ENSMUST00000102520(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000235"(astral microtubule)|go:"GO:0000776"(kinetochore)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001675"(acrosome assembly)|go:"GO:0001764"(neuron migration)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007097"(nuclear migration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007281"(germ cell development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016477"(cell migration)|go:"GO:0017145"(stem cell division)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031514"(motile cilium)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0036035"(osteoclast development)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051130"(positive regulation of cellular component organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090102"(cochlea development)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|mint:P63005|rcsb pdb:1UUJ|rcsb pdb:1VYH|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025 - - - figure legend:fig. 3b|comment:"HA-tagged K147A pulls down Ndel1 but not dynein (lanes 2 and 5). HA-tagged R212A pulls down dynein but not Ndel1 (lanes 3 and 6)."|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2021/07/21 2021/07/21 rogid:AtOowum6Uvuo3WRFXzogoOiDSXk9606 rogid:worzim1DpTldfv3SQdodqPmMozk10090 rigid:2A57mL4bU/ri3m4mZdvyLMYlmAo false myc tag:?-? ha tag:?-?|mutation with no effect:147-147|mutation disrupting interaction:212-212 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q78PB6 uniprotkb:P63004 intact:EBI-27039332|ensembl:ENSRNOP00000005574|uniprotkb:Q6IRI4 intact:EBI-917535|uniprotkb:O35592|uniprotkb:P43035|uniprotkb:P81692|uniprotkb:Q9R2A6|ensembl:ENSRNOP00000003696|ensembl:ENSRNOP00000075779 psi-mi:ndel1_rat(display_long)|uniprotkb:Ndel1(gene name)|psi-mi:Ndel1(display_short)|uniprotkb:Nude2(gene name synonym)|uniprotkb:Nudel(gene name synonym) psi-mi:lis1_rat(display_long)|uniprotkb:PAF acetylhydrolase 45 kDa subunit(gene name synonym)|uniprotkb:PAF-AH alpha(gene name synonym)|uniprotkb:Lissencephaly-1 protein(gene name synonym)|uniprotkb:Pafah1b1(gene name)|psi-mi:Pafah1b1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:Lis-1(gene name synonym)|uniprotkb:Pafaha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Pandey et al. (2011) pubmed:22114287|imex:IM-29102 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-27039409|imex:IM-29102-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621235|ensembl:ENSRNOG00000004139(gene)|ensembl:ENSRNOT00000005574(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031252"(cell leading edge)|go:"GO:0032418"(lysosome localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043203"(axon hillock)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060053"(neurofilament cytoskeleton)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033493|interpro:IPR033494|rcsb pdb:2V71|reactome:R-RNO-141444|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-5663220|reactome:R-RNO-68877|reactome:R-RNO-9648025|go:"GO:0005829"(cytosol)|refseq:NP_579854.1|refseq:XP_006246640.1 rgd:620331|refseq:NP_113951.1|refseq:XP_017453039.1|ensembl:ENSRNOG00000002755(gene)|ensembl:ENSRNOT00000003696(transcript)|ensembl:ENSRNOT00000092712(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000235"(astral microtubule)|go:"GO:0000776"(kinetochore)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001675"(acrosome assembly)|go:"GO:0001764"(neuron migration)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007097"(nuclear migration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007281"(germ cell development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016477"(cell migration)|go:"GO:0017145"(stem cell division)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031514"(motile cilium)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0036035"(osteoclast development)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051130"(positive regulation of cellular component organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090102"(cochlea development)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|reactome:R-RNO-141444|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5663220|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8854518|reactome:R-RNO-9648025 - - - figure legend:fig. 4c|comment:"Exposure of DRG cultures to roscovitine, a known inhibitor of Cdk5 (Gray et al., 1999; Kim and Ryan, 2010), reduced the amount of Ndel1 that coprecipitated with Lis1 from DRG culture extracts (Fig. 4C)."|inhibition:"roscovitine CHEBI:45307"|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-drg)|taxid:10116(dorsal root ganglia) - 2021/07/21 2021/07/21 rogid:c69FdVwX1uLP9KZrbrhxKlgGO3c10116 rogid:worzim1DpTldfv3SQdodqPmMozk10116 rigid:hhXpdGcnoF0m+2WsCrKBhT7OfjI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)