#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q86TB9 uniprotkb:Q86TB9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022156|imex:IM-29047-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:wKvd3uG3cfKt1MsTLEI/ZKeWcaA false ha tag:n-n yellow fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:Q96F86 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q6P2E9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9Y4Z0 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q8IZH2 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022169|imex:IM-29047-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N - - - figure legend:Figs. 4A-D, Supp. Fig. 7|comment:Low salt conditions 50-150nM|comment:"Interactions were not affected by the addition of RNase. (not checked for Lsm4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rigid:rAHEaclWIGAkOkurPFWliL6Vi5I false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:C9JE40 uniprotkb:Q9Y4Z0 intact:EBI-20854230|intact:EBI-28985645|ensembl:ENSP00000416673|ensembl:ENSP00000508024 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:patl2_human(display_long)|uniprotkb:PAT1-like protein 2(gene name synonym)|uniprotkb:Protein PAT1 homolog a(gene name synonym)|uniprotkb:PATL2(gene name)|psi-mi:PATL2(display_short) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022252|imex:IM-29047-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000416673|ensembl:ENSP00000508024|ensembl:ENSG00000229474(gene)|ensembl:ENST00000434130(transcript)|ensembl:ENST00000682850(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|interpro:IPR019167|interpro:IPR039900|refseq:NP_001138584.1 refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N - - - figure legend:Fig. 4A|comment:The association of LSM4 and XRN1 with PATL2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:Ijnlioz/DgEo/F4BNuTGWTrdJvU9606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 rigid:Fvb0SzddZlSpMIgyxCmHKsPZW/8 false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:C9JE40 uniprotkb:O15116 intact:EBI-20854230|intact:EBI-28985645|ensembl:ENSP00000416673|ensembl:ENSP00000508024 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl2_human(display_long)|uniprotkb:PAT1-like protein 2(gene name synonym)|uniprotkb:Protein PAT1 homolog a(gene name synonym)|uniprotkb:PATL2(gene name)|psi-mi:PATL2(display_short) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022252|imex:IM-29047-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000416673|ensembl:ENSP00000508024|ensembl:ENSG00000229474(gene)|ensembl:ENST00000434130(transcript)|ensembl:ENST00000682850(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|interpro:IPR019167|interpro:IPR039900|refseq:NP_001138584.1 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 4A|comment:The association of LSM4 and XRN1 with PATL2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:Ijnlioz/DgEo/F4BNuTGWTrdJvU9606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:Fvb0SzddZlSpMIgyxCmHKsPZW/8 false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:C9JE40 uniprotkb:Q8IZH2 intact:EBI-20854230|intact:EBI-28985645|ensembl:ENSP00000416673|ensembl:ENSP00000508024 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 psi-mi:patl2_human(display_long)|uniprotkb:PAT1-like protein 2(gene name synonym)|uniprotkb:Protein PAT1 homolog a(gene name synonym)|uniprotkb:PATL2(gene name)|psi-mi:PATL2(display_short) psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022252|imex:IM-29047-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000416673|ensembl:ENSP00000508024|ensembl:ENSG00000229474(gene)|ensembl:ENST00000434130(transcript)|ensembl:ENST00000682850(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|interpro:IPR019167|interpro:IPR039900|refseq:NP_001138584.1 refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N - - - figure legend:Fig. 4A|comment:The association of LSM4 and XRN1 with PATL2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:Ijnlioz/DgEo/F4BNuTGWTrdJvU9606 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rigid:Fvb0SzddZlSpMIgyxCmHKsPZW/8 false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q6P2E9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022263|imex:IM-29047-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rigid:eg/6Lg/KnEAtWtvU0h32EsSEqwU false ha tag:n-n|yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022263|imex:IM-29047-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:eg/6Lg/KnEAtWtvU0h32EsSEqwU false ha tag:n-n|yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022263|imex:IM-29047-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:eg/6Lg/KnEAtWtvU0h32EsSEqwU false ha tag:n-n|yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q8IZH2 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022263|imex:IM-29047-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rigid:eg/6Lg/KnEAtWtvU0h32EsSEqwU false ha tag:n-n|yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022282|imex:IM-29047-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Figs. 4D|comment:Hign salt conditions 300-500nM|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:b8PNpR+wZrPYt3PXNBMjWoI0qGo false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9Y4Z0 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022282|imex:IM-29047-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N - - - figure legend:Figs. 4D|comment:Hign salt conditions 300-500nM|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 rigid:b8PNpR+wZrPYt3PXNBMjWoI0qGo false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022282|imex:IM-29047-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Figs. 4D|comment:Hign salt conditions 300-500nM|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:b8PNpR+wZrPYt3PXNBMjWoI0qGo false ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26196 uniprotkb:Q86TB9 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022347|imex:IM-29047-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Figs 5B, 5C|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:CvAxOc2XtmK9L8TUz9/FOAV+8Xw false - sufficient binding region:1-84|ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O15116 uniprotkb:Q86TB9 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022358|imex:IM-29047-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Figs 5B, 5D|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:qAGpVxKo3pih1y/Q/ImA1VhJSFU false - sufficient binding region:388-770|ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022487|imex:IM-29047-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:0bTWLnO0gC67eDGjGHLpbBrnf8I false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022487|imex:IM-29047-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:0bTWLnO0gC67eDGjGHLpbBrnf8I false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:A5YKK6 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022487|imex:IM-29047-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606 rigid:0bTWLnO0gC67eDGjGHLpbBrnf8I false yellow fluorescent protein tag:c-c flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022499|imex:IM-29047-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:WBo/7Hnfybcw48TNnG8J07TEenc false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:A5YKK6 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022499|imex:IM-29047-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606 rigid:WBo/7Hnfybcw48TNnG8J07TEenc false yellow fluorescent protein tag:c-c flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:Q9ULM6 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022513|imex:IM-29047-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 rigid:lPPsl+dumPwZKE/uo4nYCEA2cQk false yellow fluorescent protein tag:c-c myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022513|imex:IM-29047-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:lPPsl+dumPwZKE/uo4nYCEA2cQk false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022513|imex:IM-29047-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:lPPsl+dumPwZKE/uo4nYCEA2cQk false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9ULM6 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022524|imex:IM-29047-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 rigid:xKrW207yI/D7BCJMYLzKEGsgur0 false yellow fluorescent protein tag:c-c myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022524|imex:IM-29047-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:xKrW207yI/D7BCJMYLzKEGsgur0 false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9UIV1 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025038|imex:IM-29047-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rigid:KgCRMjwNjtMx/vomalnOsCLAcss false yellow fluorescent protein tag:c-c ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025038|imex:IM-29047-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:KgCRMjwNjtMx/vomalnOsCLAcss false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025038|imex:IM-29047-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:KgCRMjwNjtMx/vomalnOsCLAcss false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9UIV1 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025049|imex:IM-29047-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rigid:QtXYvOQvIcfmMCMCv2DQcb/CZTo false yellow fluorescent protein tag:c-c ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025049|imex:IM-29047-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:QtXYvOQvIcfmMCMCv2DQcb/CZTo false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9UFF9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-742299|uniprotkb:O95709|uniprotkb:Q7Z521|uniprotkb:Q9H6Y1|uniprotkb:D3DQI8|uniprotkb:B2RAR8|intact:EBI-10979182|uniprotkb:B0AZS3|uniprotkb:B7Z8R1|ensembl:ENSP00000285896|ensembl:ENSP00000384747|ensembl:ENSP00000430493 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot8_human(display_long)|uniprotkb:CNOT8(gene name)|psi-mi:CNOT8(display_short)|uniprotkb:CALIF(gene name synonym)|uniprotkb:POP2(gene name synonym)|uniprotkb:CCR4-associated factor 8(gene name synonym)|uniprotkb:CAF1-like protein(gene name synonym)|uniprotkb:CAF2(gene name synonym)|uniprotkb:Caf1b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025059|imex:IM-29047-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004770.4|refseq:XP_005268584.1|refseq:NP_001288002.1|refseq:NP_001288003.1|refseq:NP_001288004.1|refseq:NP_001288006.1|refseq:NP_001288009.1|refseq:NP_001288011.1|refseq:NP_001288012.1|refseq:NP_001288015.1|refseq:XP_011536008.1|refseq:XP_011536010.1|refseq:XP_016865537.1|refseq:XP_016865538.1|refseq:XP_016865539.1|refseq:XP_016865540.1|refseq:XP_016865541.1|refseq:XP_016865542.1|refseq:XP_016865543.1|refseq:XP_016865544.1|refseq:XP_016865545.1|refseq:XP_016865546.1|ensembl:ENSG00000155508(gene)|ensembl:ENST00000285896(transcript)|ensembl:ENST00000403027(transcript)|ensembl:ENST00000517876(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR027212|interpro:IPR036397|interpro:IPR039637|mint:Q9UFF9|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-29084N - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pjaQYzYBGJWC7z5R5s8Te+v2sRA9606 rigid:DJfr9EQW4+ZDjmcmcksyBhpPBCw false yellow fluorescent protein tag:c-c ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025059|imex:IM-29047-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 500-1000mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:DJfr9EQW4+ZDjmcmcksyBhpPBCw false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025069|imex:IM-29047-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:giZ4MK8xGQE7dawrSJjrQ/D/C7E false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025069|imex:IM-29047-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:giZ4MK8xGQE7dawrSJjrQ/D/C7E false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q9UFF9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-742299|uniprotkb:O95709|uniprotkb:Q7Z521|uniprotkb:Q9H6Y1|uniprotkb:D3DQI8|uniprotkb:B2RAR8|intact:EBI-10979182|uniprotkb:B0AZS3|uniprotkb:B7Z8R1|ensembl:ENSP00000285896|ensembl:ENSP00000384747|ensembl:ENSP00000430493 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:cnot8_human(display_long)|uniprotkb:CNOT8(gene name)|psi-mi:CNOT8(display_short)|uniprotkb:CALIF(gene name synonym)|uniprotkb:POP2(gene name synonym)|uniprotkb:CCR4-associated factor 8(gene name synonym)|uniprotkb:CAF1-like protein(gene name synonym)|uniprotkb:CAF2(gene name synonym)|uniprotkb:Caf1b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025069|imex:IM-29047-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004770.4|refseq:XP_005268584.1|refseq:NP_001288002.1|refseq:NP_001288003.1|refseq:NP_001288004.1|refseq:NP_001288006.1|refseq:NP_001288009.1|refseq:NP_001288011.1|refseq:NP_001288012.1|refseq:NP_001288015.1|refseq:XP_011536008.1|refseq:XP_011536010.1|refseq:XP_016865537.1|refseq:XP_016865538.1|refseq:XP_016865539.1|refseq:XP_016865540.1|refseq:XP_016865541.1|refseq:XP_016865542.1|refseq:XP_016865543.1|refseq:XP_016865544.1|refseq:XP_016865545.1|refseq:XP_016865546.1|ensembl:ENSG00000155508(gene)|ensembl:ENST00000285896(transcript)|ensembl:ENST00000403027(transcript)|ensembl:ENST00000517876(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR027212|interpro:IPR036397|interpro:IPR039637|mint:Q9UFF9|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-29084N - - - figure legend:Fig. 7E|comment:Complex observed at 150-300mM salt|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/28 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pjaQYzYBGJWC7z5R5s8Te+v2sRA9606 rigid:giZ4MK8xGQE7dawrSJjrQ/D/C7E false yellow fluorescent protein tag:c-c ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P26196 uniprotkb:Q86TB9 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025617|imex:IM-29047-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Supp. Fig. 7|comment:"Interactions were not affected by the addition of RNase (Not checked for LSM4)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:CvAxOc2XtmK9L8TUz9/FOAV+8Xw false - ha tag:n-n|sufficient binding region:1-388 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q96F86 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025627|imex:IM-29047-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N - - - figure legend:Supp. Fig. 7|comment:Interactions were not affected by the addition of RNase|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 rigid:xmliGV2pmIER/afsFRF3MvYYJG0 false ha tag:n-n|sufficient binding region:389-770 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q6P2E9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025627|imex:IM-29047-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N - - - figure legend:Supp. Fig. 7|comment:Interactions were not affected by the addition of RNase|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rigid:xmliGV2pmIER/afsFRF3MvYYJG0 false ha tag:n-n|sufficient binding region:389-770 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025627|imex:IM-29047-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Supp. Fig. 7|comment:Interactions were not affected by the addition of RNase|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:xmliGV2pmIER/afsFRF3MvYYJG0 false ha tag:n-n|sufficient binding region:389-770 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:Q8IZH2 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025627|imex:IM-29047-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N - - - figure legend:Supp. Fig. 7|comment:Interactions were not affected by the addition of RNase|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rigid:xmliGV2pmIER/afsFRF3MvYYJG0 false ha tag:n-n|sufficient binding region:389-770 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27029166|imex:IM-29047-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N - - - figure legend:Figs 5B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/07/06 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:MCaLz98+K58Qs/jNqwAqdyFk3I8 false sufficient binding region:388-770|ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86TB9 uniprotkb:O15116 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27029166|imex:IM-29047-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) - - - figure legend:Figs 5B|comment:Interactions were not affected by the addition of RNase.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/07/06 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:MCaLz98+K58Qs/jNqwAqdyFk3I8 false sufficient binding region:388-770|ha tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UIV1 uniprotkb:Q86TB9 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27029230|imex:IM-29047-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/07/06 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:ShGO+8ZTpXlgsaeiLuPjDWi0Zgk false - yellow fluorescent protein tag:c-c|sufficient binding region:1-388 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZH2 uniprotkb:O15116 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022311|imex:IM-29047-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:Dh9w4QYEKBNv89kes9oIlgXjqo0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZH2 uniprotkb:Q86TB9 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022311|imex:IM-29047-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:Dh9w4QYEKBNv89kes9oIlgXjqo0 false - ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q6P2E9 uniprotkb:O15116 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022326|imex:IM-29047-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:/slBh47PtOQL9qcJQXCGn7kLNTA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6P2E9 uniprotkb:Q8IZH2 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 intact:EBI-372406|uniprotkb:Q4G0S3|uniprotkb:Q68D88|uniprotkb:Q6AI24|uniprotkb:Q6MZS8|uniprotkb:Q86WS7|uniprotkb:Q8N8U4|uniprotkb:Q9UF39|ensembl:ENSP00000264951 psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:xrn1_human(display_long)|uniprotkb:Strand-exchange protein 1 homolog(gene name synonym)|uniprotkb:XRN1(gene name)|psi-mi:XRN1(display_short)|uniprotkb:SEP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022326|imex:IM-29047-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N refseq:NP_061874.3|refseq:NP_001269786.1|refseq:NP_001269788.1|ensembl:ENSG00000114127(gene)|ensembl:ENST00000264951(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033574"(response to testosterone)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071409"(cellular response to cycloheximide)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1905795"(cellular response to puromycin)|interpro:IPR004859(Putative 5-3 exonuclease)|interpro:IPR016494(5'-3' exoribonuclease 1)|interpro:IPR027073|interpro:IPR040992|interpro:IPR041106|interpro:IPR041385|interpro:IPR041412|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|dip:DIP-31174N go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rogid:Y5wskamFEhJ+vmrGjlw4nYHiWLg9606 rigid:/slBh47PtOQL9qcJQXCGn7kLNTA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6P2E9 uniprotkb:Q86TB9 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022326|imex:IM-29047-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:/slBh47PtOQL9qcJQXCGn7kLNTA false - ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26196 uniprotkb:O15116 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 intact:EBI-347619|uniprotkb:B2R5E6|ensembl:ENSP00000310596 psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:lsm1_human(display_long)|uniprotkb:LSM1(gene name)|psi-mi:LSM1(display_short)|uniprotkb:CASM(gene name synonym)|uniprotkb:Cancer-associated Sm-like(gene name synonym)|uniprotkb:Small nuclear ribonuclear CaSm(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022339|imex:IM-29047-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N refseq:NP_055277.1|dip:DIP-31130N|ensembl:ENSG00000175324(gene)|ensembl:ENST00000311351(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034104|interpro:IPR044642|reactome:R-HSA-430039|go:"GO:0000932"(P-body) go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rogid:4ZjCoUTZoEAWqp5wvQDTcTr4gs49606 rigid:MCaLz98+K58Qs/jNqwAqdyFk3I8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26196 uniprotkb:Q86TB9 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022339|imex:IM-29047-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 go:"GO:0005737"(cytoplasm) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:MCaLz98+K58Qs/jNqwAqdyFk3I8 false - ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IU60 uniprotkb:Q86TB9 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022377|imex:IM-29047-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Figs. 6A, 6C, Supp. Fig. 8|comment:"Interaction is RNA-independent and stable in high salt conditions (1M)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:wgmyqi+Wdt8TcOCB07rHJ69Nn/c false flag tag:?-? yellow fluorescent protein tag:c-c|sufficient binding region:85-388|sufficient binding region:389-770 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NPI6 uniprotkb:Q86TB9 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022393|imex:IM-29047-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Figs. 6B, 6C, Supp fig. 8|comment:"Interaction is RNA-independent and stable in high salt conditions (1M)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:i3l+GyYAPohk6K9ry0gQdh0+9+A false flag tag:?-? yellow fluorescent protein tag:c-c|sufficient binding region:85-388|sufficient binding region:389-770 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A5YKK6 uniprotkb:Q86TB9 intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022407|imex:IM-29047-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7A, Supp. Fig. 9A|comment:Interaction is RNA-independent. A weak interaction of CNOT1 with region 389-770 of PATL1 was also observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:LaLGtTe+wr7liWFti1SVWJikKU8 false flag tag:n-n yellow fluorescent protein tag:c-c|sufficient binding region:1-388 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9ULM6 uniprotkb:Q86TB9 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022420|imex:IM-29047-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7B, Supp Fig. 9B|comment:Interaction is RNA-independent. Interaction of CNOT6 with region 389-770 of PATL1 is weak.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:bRaOno6Hrcd+GNusBYDbzXKj134 false myc tag:?-? yellow fluorescent protein tag:c-c|sufficient binding region:1-388|sufficient binding region:389-770 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UFF9 uniprotkb:Q86TB9 intact:EBI-742299|uniprotkb:O95709|uniprotkb:Q7Z521|uniprotkb:Q9H6Y1|uniprotkb:D3DQI8|uniprotkb:B2RAR8|intact:EBI-10979182|uniprotkb:B0AZS3|uniprotkb:B7Z8R1|ensembl:ENSP00000285896|ensembl:ENSP00000384747|ensembl:ENSP00000430493 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot8_human(display_long)|uniprotkb:CNOT8(gene name)|psi-mi:CNOT8(display_short)|uniprotkb:CALIF(gene name synonym)|uniprotkb:POP2(gene name synonym)|uniprotkb:CCR4-associated factor 8(gene name synonym)|uniprotkb:CAF1-like protein(gene name synonym)|uniprotkb:CAF2(gene name synonym)|uniprotkb:Caf1b(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022461|imex:IM-29047-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004770.4|refseq:XP_005268584.1|refseq:NP_001288002.1|refseq:NP_001288003.1|refseq:NP_001288004.1|refseq:NP_001288006.1|refseq:NP_001288009.1|refseq:NP_001288011.1|refseq:NP_001288012.1|refseq:NP_001288015.1|refseq:XP_011536008.1|refseq:XP_011536010.1|refseq:XP_016865537.1|refseq:XP_016865538.1|refseq:XP_016865539.1|refseq:XP_016865540.1|refseq:XP_016865541.1|refseq:XP_016865542.1|refseq:XP_016865543.1|refseq:XP_016865544.1|refseq:XP_016865545.1|refseq:XP_016865546.1|ensembl:ENSG00000155508(gene)|ensembl:ENST00000285896(transcript)|ensembl:ENST00000403027(transcript)|ensembl:ENST00000517876(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR027212|interpro:IPR036397|interpro:IPR039637|mint:Q9UFF9|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-29084N refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7C|comment:Interaction is RNA-independent|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:pjaQYzYBGJWC7z5R5s8Te+v2sRA9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:z9UEsXnGvOmiJ854ZBqO8vvjFas false ha tag:?-? yellow fluorescent protein tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UIV1 uniprotkb:Q86TB9 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-27022474|imex:IM-29047-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7C|comment:Interaction is RNA-independent|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/24 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:ShGO+8ZTpXlgsaeiLuPjDWi0Zgk false ha tag:?-? yellow fluorescent protein tag:c-c|sufficient binding region:1-388 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UIV1 uniprotkb:Q8IU60 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025601|imex:IM-29047-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 - - - figure legend:Fig. 7F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rigid:lv4ZRkrT7IMSRPb85gvNPRexMaU false green fluorescent protein tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UIV1 uniprotkb:Q86TB9 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-27025601|imex:IM-29047-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 - - - figure legend:Fig. 7F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2021/06/22 2021/06/29 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rigid:lv4ZRkrT7IMSRPb85gvNPRexMaU false green fluorescent protein tag:?-? ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q86TB9 uniprotkb:P26196 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-27029602|imex:IM-29047-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N go:"GO:0000932"(P-body) - - figure legend:Supp. Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2021/06/22 2021/07/07 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 rigid:CvAxOc2XtmK9L8TUz9/FOAV+8Xw false yellow fluorescent protein tag:c-c - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q86TB9 uniprotkb:Q6P2E9 intact:EBI-2562092|uniprotkb:Q8N9M6|uniprotkb:Q2TA86|uniprotkb:Q8NI63|uniprotkb:Q6P166|intact:EBI-2824962|uniprotkb:B3KXT9|ensembl:ENSP00000300146 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:patl1_human(display_long)|uniprotkb:PATL1(gene name)|psi-mi:PATL1(display_short)|uniprotkb:PAT1-like protein 1(gene name synonym)|uniprotkb:OK/KNS-cl.5(orf name)|uniprotkb:Protein PAT1 homolog b(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ozgur et al. (2010) imex:IM-29047|pubmed:20584987 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-27029615|imex:IM-29047-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689929.2|ensembl:ENSG00000166889(gene)|ensembl:ENST00000300146(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0033962"(P-body assembly)|go:"GO:0034046"("poly(G) binding")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR019167|interpro:IPR039900|rcsb pdb:2XEQ|rcsb pdb:2XER|rcsb pdb:2XES|reactome:R-HSA-430039 ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N go:"GO:0000932"(P-body) - - figure legend:Supp. Fig 3F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line) - 2021/06/22 2021/07/07 rogid:zSppgni6nHKLE+wKkvoXmECuXB09606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 rigid:AB9PPgjIMxGOTHG64wFwawwd/eo false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)