#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05026	uniprotkb:O76024	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:"MI:0018"(two hybrid)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26982152|imex:IM-28979-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	-	-	-	figure legend:NA|comment:we undertook a yeast two-hybrid screen using the WFS1 Cterminal domain as bait in a human cDNA library. Using this and complementary approaches we identify the Na+/K+ATPase beta-1 subunit as a novel interacting partner|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2021/05/28	2021/05/28	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	sufficient binding region:113-303	sufficient binding region:652-890	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05026	uniprotkb:O76024	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26982170|imex:IM-28979-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	-	-	-	figure legend:Fig. 2B-D|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2021/05/28	2021/05/28	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	ha tag:n-n	necessary binding region:652-890|myc tag:n-n|necessary binding region:322-652	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05026	uniprotkb:O76024	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26982183|imex:IM-28979-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	-	-	-	figure legend:Fig. 1B|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2021/05/28	2021/05/28	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	sufficient binding region:113-303|ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P05026	uniprotkb:O76024	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26987951|imex:IM-28979-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	-	-	-	figure legend:Fig. 1A|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2021/05/28	2021/06/08	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	sufficient binding region:113-303|ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O76024	uniprotkb:P05026	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26982203|imex:IM-28979-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	-	-	figure legend:Fig. 3A|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jeg3)|taxid:9606(Homo sapiens choriocarcinoma JEG3)	-	2021/05/28	2021/05/28	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O76024	uniprotkb:P05026	intact:EBI-720609|uniprotkb:Q8N6I3|uniprotkb:Q9UNW6|uniprotkb:B2R797|uniprotkb:D3DVT1|ensembl:ENSP00000226760|ensembl:ENSP00000423337|ensembl:ENSP00000506978	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:wfs1_human(display_long)|uniprotkb:WFS1(gene name)|psi-mi:WFS1(display_short)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zatyka et al. (2008)	imex:IM-28979|pubmed:17947299	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-26982221|imex:IM-28979-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903892"(negative regulation of ATF6-mediated unfolded protein response)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR026208|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050877"(nervous system process)|go:"GO:0051117"(ATPase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR026209|refseq:NP_001139325.1|refseq:NP_005996.2|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030141"(secretory granule)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031016"(pancreas development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENSG00000109501(gene)|ensembl:ENST00000226760(transcript)|ensembl:ENST00000503569(transcript)|ensembl:ENST00000684087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001822"(kidney development)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|mint:O76024	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	-	-	-	figure legend:Fig. 3B|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Brain Disease - Neurological Diseases & Disorders|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sk-n-as)|taxid:9606(human sk-n-as neuroblatoma cell line)	-	2021/05/28	2021/05/28	rogid:bt4NKJUKyrQeJ8emdvrT3sg0Rf49606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	rigid:KEKAFC94Bx6R7Uxu/QnH6G4Tvq8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)