#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00610	uniprotkb:P35348	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283112|imex:IM-26920-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 5, 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:qS0OvHwjJTMmRfXJvI4e8AnCa2k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09496	uniprotkb:P35348	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283119|imex:IM-26920-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 5,6|agonist:"noradrenaline -CHEBI:33569"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:9bG4zRS6N1ugghNLL3NXYIsJvFA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09497	uniprotkb:P35348	intact:EBI-726598|uniprotkb:Q6FHW1|uniprotkb:Q53Y37|ensembl:ENSP00000309415	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clcb_human(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283123|imex:IM-26920-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001825.1|refseq:NP_009028.1|ensembl:ENSG00000175416(gene)|ensembl:ENST00000310418(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060170"(ciliary membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 5,6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:xiV7woFwZVVWs+Ter10SElj68V09606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:8R4ipNDLE209Zavt7yN6mgD8P28	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00610	uniprotkb:P35348	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283136|imex:IM-26920-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 4|comment:Clathrin HC, LCA and LCB colocalised with a marker for smooth muscle.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:qS0OvHwjJTMmRfXJvI4e8AnCa2k	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P09496	uniprotkb:P35348	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283141|imex:IM-26920-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 4i|comment:Clathrin HC, LCA and LCB colocalised with a marker for smooth muscle.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:9bG4zRS6N1ugghNLL3NXYIsJvFA	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:P09497	uniprotkb:P35348	intact:EBI-726598|uniprotkb:Q6FHW1|uniprotkb:Q53Y37|ensembl:ENSP00000309415	intact:EBI-489756|uniprotkb:O60451|uniprotkb:Q13675|uniprotkb:Q13729|uniprotkb:Q6RUJ4|uniprotkb:Q6RUJ5|uniprotkb:Q6RUJ7|uniprotkb:Q6RUJ8|uniprotkb:Q6RUJ9|uniprotkb:Q9UD63|uniprotkb:B0ZBD2|uniprotkb:B0ZBD6|uniprotkb:B0ZBD8|uniprotkb:Q4VBM7|uniprotkb:Q96RE8|uniprotkb:Q9UD67|uniprotkb:B0ZBD1|uniprotkb:B0ZBD4|uniprotkb:B0ZBD5|uniprotkb:B0ZBD9|uniprotkb:A8K0I3|ensembl:ENSP00000276393|ensembl:ENSP00000369947	psi-mi:clcb_human(display_long)|uniprotkb:CLTB(gene name)|psi-mi:CLTB(display_short)	psi-mi:ada1a_human(display_long)|uniprotkb:Alpha-1A adrenoreceptor(gene name synonym)|uniprotkb:Alpha-1C adrenergic receptor(gene name synonym)|uniprotkb:Alpha-adrenergic receptor 1c(gene name synonym)|uniprotkb:ADRA1A(gene name)|psi-mi:ADRA1A(display_short)|uniprotkb:ADRA1C(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hennenberg et al. (2013)	pubmed:23460120|imex:IM-26920	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21283146|imex:IM-26920-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001825.1|refseq:NP_009028.1|ensembl:ENSG00000175416(gene)|ensembl:ENST00000310418(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0060170"(ciliary membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828	go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|refseq:NP_000671.2|refseq:NP_150645.2|refseq:NP_150646.3|refseq:NP_150647.2|refseq:XP_006716356.1|refseq:XP_011542713.1|ensembl:ENSG00000120907(gene)|ensembl:ENST00000276393(transcript)|ensembl:ENST00000380573(transcript)|go:"GO:0001985"(negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0001994"(norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0005737"(cytoplasm)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|go:"GO:0097195"(pilomotor reflex)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001004(Adrenergic receptor, alpha 1C subtype)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35348|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0042493"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060073"(micturition)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|refseq:NP_001309431.1|refseq:NP_001309432.1|refseq:NP_001309433.1|dip:DIP-33401N	-	-	-	figure legend:Figure 4ii|comment:Clathrin HC, LCA and LCB colocalised with a marker for smooth muscle.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-prostate tissue)|taxid:9606(Homo sapiens)	-	2019/03/19	2019/03/27	rogid:xiV7woFwZVVWs+Ter10SElj68V09606	rogid:Y/tnIWKpCfP2lFJDTS69YGxDywg9606	rigid:8R4ipNDLE209Zavt7yN6mgD8P28	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)