#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBN7	uniprotkb:O43490-2	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-21452032|ensembl:ENSP00000426090|ensembl:ENSP00000427346	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:o43490-2(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)|uniprotkb:AC133-2(isoform synonym)|uniprotkb:S1(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451261|imex:IM-27077-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	intact:EBI-3447549(isoform-parent)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000505450(transcript)|ensembl:ENST00000508167(transcript)	-	-	-	figure legend:Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/05/08	2019/06/12	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:6lf+y0WJsjsdQT8C7GPehsqvnQQ9606	rigid:HrpfSjy49TFQDAhCW/eGWIk6fZc	false	-	flag tag:c-c|his tag:c-c|strep tag:c-c	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UBN7	uniprotkb:P35222	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451279|imex:IM-27077-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:Supplementary Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBN7	uniprotkb:O43490	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451279|imex:IM-27077-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/11	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43490	uniprotkb:P35222	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451290|imex:IM-27077-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	-	-	-	figure legend:Supplementary Figure 1A, figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/11	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43490	uniprotkb:Q9UBN7	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451290|imex:IM-27077-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:Supplementary Figure 1A, figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/11	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35222	uniprotkb:Q9UBN7	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451502|imex:IM-27077-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:Figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/12	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35222	uniprotkb:O43490	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451502|imex:IM-27077-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/12	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBN7	uniprotkb:O43490-2	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-21452032|ensembl:ENSP00000426090|ensembl:ENSP00000427346	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:o43490-2(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)|uniprotkb:AC133-2(isoform synonym)|uniprotkb:S1(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451303|imex:IM-27077-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	intact:EBI-3447549(isoform-parent)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000505450(transcript)|ensembl:ENST00000508167(transcript)	-	-	-	figure legend:Figure 1A/B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/12	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:6lf+y0WJsjsdQT8C7GPehsqvnQQ9606	rigid:HrpfSjy49TFQDAhCW/eGWIk6fZc	false	-	flag tag:c-c|his tag:c-c|sufficient binding region:1-445|strep tag:c-c|necessary binding region:133-445	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43490	uniprotkb:Q9UBN7	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451318|imex:IM-27077-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:Figure 1C/D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/06/11	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:kU4rSB41Ri74vAY41oGPuFsnwZQ	false	-	flag tag:?-?|his tag:?-?|mutation disrupting interaction strength:568-568|strep tag:?-?|necessary binding region:504-840(IPR037138)|mutation with no effect:568-568|mutation disrupting interaction strength:570-570|mutation with no effect:570-570|mutation with no effect:216-216,611-611	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBN7	uniprotkb:O43490	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451486|imex:IM-27077-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Figure 1E, Supplementary Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/23	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:kU4rSB41Ri74vAY41oGPuFsnwZQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35222	uniprotkb:Q9UBN7	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451584|imex:IM-27077-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N	-	-	-	figure legend:Supplementary figure 6A|comment:"A striking colocalization of CD133 and beta-catenin ( Pearson’s correlation = 0.82) was found. By contrast, only a small fraction of HDAC6 colocalized with CD133 and beta-catenin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/07/22	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P35222	uniprotkb:O43490	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451584|imex:IM-27077-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary figure 6A|comment:"A striking colocalization of CD133 and beta-catenin ( Pearson’s correlation = 0.82) was found. By contrast, only a small fraction of HDAC6 colocalized with CD133 and beta-catenin."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/07/22	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:8wZNkBUhys00pbngBtAYOYwQnLM	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q8NA47	uniprotkb:O43490	intact:EBI-20851346|ensembl:ENSP00000312399|uniprotkb:B4DY03|uniprotkb:Q0P603|uniprotkb:Q6P2E1	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ccd63_human(display_long)|uniprotkb:CCDC63(gene name)|psi-mi:CCDC63(display_short)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21452019|imex:IM-27077-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173093(gene)|ensembl:ENST00000308208(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0005930"(axoneme)|go:"GO:0007286"(spermatid development)|go:"GO:0036158"(outer dynein arm assembly)|interpro:IPR029652|refseq:NP_001273172.1|refseq:NP_001273173.1|refseq:NP_689804.1|refseq:XP_006719325.1|refseq:XP_011536301.1|refseq:XP_011536303.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Figure 2E, supplementary figure 3D|agonist:Tubacin -a HDAC6-specific small-molecule inhibitor|comment:Cells treated with  HDAC6 shRNAs showed greater colocalisation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma)	-	2019/05/08	2019/07/22	rogid:O3gKjXDMTlSDS3UWaqeOwmV+UCw9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:Z3WH0mWrlEhPJ2ZLsTLesUdHpgE	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q96EC8	uniprotkb:O43490	intact:EBI-751210|uniprotkb:Q5JP08|uniprotkb:B4E1U7|uniprotkb:G5E997|ensembl:ENSP00000417573	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:yipf6_human(display_long)|uniprotkb:YIP1 family member 6(gene name synonym)|uniprotkb:YIPF6(gene name)|psi-mi:YIPF6(display_short)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451649|imex:IM-27077-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776195.2|refseq:NP_001182143.1|ensembl:ENSG00000181704(gene)|ensembl:ENST00000462683(transcript)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0060576"(intestinal epithelial cell development)|interpro:IPR006977(Yip1 domain)|mint:Q96EC8|reactome:R-HSA-432722	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:mfHkmdPyX5lK/euzg8v1Ydikf5w9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:lUO8mr3zbORpr7uzF1Wdufxmc1k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P00167	uniprotkb:O43490	intact:EBI-1047284|uniprotkb:A8MV91|uniprotkb:Q6IB14|uniprotkb:F8WEU4|ensembl:ENSP00000341625	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:cyb5_human(display_long)|uniprotkb:CYB5A(gene name)|psi-mi:CYB5A(display_short)|uniprotkb:CYB5(gene name synonym)|uniprotkb:Microsomal cytochrome b5 type A(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451660|imex:IM-27077-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001905.1|refseq:NP_683725.1|refseq:XP_011524137.1|refseq:NP_001177736.1|go:"GO:0005829"(cytosol)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR018506|interpro:IPR036400|rcsb pdb:2I96|reactome:R-HSA-196836|reactome:R-HSA-9609523|ensembl:ENSG00000166347(gene)|ensembl:ENST00000340533(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:nZ/xafhkGjHBGCIWhtvBD1mtVSQ9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:ZM3ksPnaL1i4zQ66kDL2oR4fI8Q	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y6X1	uniprotkb:O43490	intact:EBI-10329948|uniprotkb:D3DNI6|ensembl:ENSP00000239944|ensembl:ENSP00000420076	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:serp1_human(display_long)|uniprotkb:SERP1(gene name)|psi-mi:SERP1(display_short)|uniprotkb:RAMP4(gene name synonym)|uniprotkb:Ribosome-attached membrane protein 4(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451664|imex:IM-27077-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055260.1|refseq:XP_011511000.1|ensembl:ENSG00000120742(gene)|ensembl:ENST00000239944(transcript)|ensembl:ENST00000479209(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0060124"(positive regulation of growth hormone secretion)|interpro:IPR010580(Ribosome associated membrane RAMP4)|reactome:R-HSA-381038|reactome:R-HSA-9609523	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:4QEqtf4DYSOlxJHsrHPN8xo4EOI9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:ziEgplbrLpJ+bjOWZVa4IQswlAA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08962	uniprotkb:O43490	intact:EBI-762053|uniprotkb:Q5TZP3|uniprotkb:Q9UCG6|uniprotkb:Q8N6Z9|uniprotkb:F8VZE2|ensembl:ENSP00000257857|ensembl:ENSP00000393502|ensembl:ENSP00000447730|ensembl:ENSP00000449337	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:cd63_human(display_long)|uniprotkb:Melanoma-associated antigen ME491(gene name synonym)|uniprotkb:Ocular melanoma-associated antigen(gene name synonym)|uniprotkb:OMA81H(gene name synonym)|uniprotkb:Granulophysin(gene name synonym)|uniprotkb:Tetraspanin-30(gene name synonym)|uniprotkb:Lysosomal-associated membrane protein 3(gene name synonym)|uniprotkb:CD63(gene name)|psi-mi:CD63(display_short)|uniprotkb:MLA1(gene name synonym)|uniprotkb:TSPAN30(gene name synonym)|uniprotkb:Lysosome integral membrane protein 1(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451668|imex:IM-27077-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001771.1|refseq:NP_001244330.1|refseq:NP_001244318.1|refseq:NP_001244319.1|refseq:NP_001244320.1|refseq:NP_001244329.1|refseq:NP_001254627.1|refseq:NP_001244321.1|ensembl:ENSG00000135404(gene)|ensembl:ENST00000257857(transcript)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|interpro:IPR042028|mint:P08962|reactome:R-HSA-114608|reactome:R-HSA-6798695|go:"GO:0097487"(multivesicular body, internal vesicle)|ensembl:ENST00000420846(transcript)|ensembl:ENST00000549117(transcript)|ensembl:ENST00000552692(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016477"(cell migration)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048757"(pigment granule maturation)|go:"GO:0070062"(extracellular exosome)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:stCGi5kkTMIdO84qSwjmjpUwwvs9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:9zAyfNpZ/1h74s69pJi0yFY7hws	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96A57	uniprotkb:O43490	intact:EBI-723971|uniprotkb:D3DVZ9|uniprotkb:Q0VGC8|uniprotkb:Q5TDS5|uniprotkb:Q96ES2|uniprotkb:Q9P0A7|uniprotkb:B2RDM8|ensembl:ENSP00000202834|ensembl:ENSP00000368579|ensembl:ENSP00000368581|ensembl:ENSP00000368585|ensembl:ENSP00000368588|ensembl:ENSP00000368601	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:tm230_human(display_long)|uniprotkb:TMEM230(gene name)|psi-mi:TMEM230(display_short)|uniprotkb:C20orf30(gene name synonym)|uniprotkb:HSPC274(orf name)|uniprotkb:UNQ2432/PRO4992(orf name)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451672|imex:IM-27077-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001009923.1|refseq:NP_001009924.1|refseq:NP_001009925.1|refseq:NP_054864.3|refseq:NP_001317913.1|refseq:NP_001317914.1|refseq:NP_001317915.1|refseq:XP_016883325.1|ensembl:ENSG00000089063(gene)|ensembl:ENST00000202834(transcript)|ensembl:ENST00000379277(transcript)|ensembl:ENST00000379279(transcript)|ensembl:ENST00000379283(transcript)|ensembl:ENST00000379286(transcript)|ensembl:ENST00000379299(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0055037"(recycling endosome)|interpro:IPR008590(Protein of unknown function DUF872, eukaryotic)|interpro:IPR044234	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:n9vIcFyub2Fl+lSnmvcQ1DrA7PE9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:SKvhOE2nB9Pd5uVHpE5haqqEV1c	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13500	uniprotkb:O43490	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451676|imex:IM-27077-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:P/1KN7O16V+KAorPMSlMluziStk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8NI32-2	uniprotkb:O43490	intact:EBI-21451760|ensembl:ENSP00000387077	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:q8ni32-2(display_long)|uniprotkb:LYPD6B(gene name)|psi-mi:LYPD6B(display_short)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451680|imex:IM-27077-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-21495507(isoform-parent)|ensembl:ENSG00000150556(gene)|ensembl:ENST00000409642(transcript)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	isoform-comment:No experimental confirmation available.	-	figure legend:Supplementary Table 2 -7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:6yPhRLRxhqEyGvTt6JpRcH7E6wE9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:8gqxHFQwFPlXRGNcVvX0zBdvS2k	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51572	uniprotkb:O43490	intact:EBI-77683|ensembl:ENSP00000343458|ensembl:ENSP00000494052|ensembl:ENSP00000499882|uniprotkb:Q13836|uniprotkb:Q96CF0|uniprotkb:D3DWV5|uniprotkb:B3KQ79	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:bap31_human(display_long)|uniprotkb:BCAP31(gene name)|psi-mi:BCAP31(display_short)|uniprotkb:BAP31(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:6C6-AG tumor-associated antigen(gene name synonym)|uniprotkb:DXS1357E(gene name synonym)|uniprotkb:Protein CDM(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451684|imex:IM-27077-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001132913.1|refseq:NP_005736.3|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904154"(positive regulation of retrograde protein transport, ER to cytosol)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:P51572|rcsb pdb:4JZL|rcsb pdb:4JZP|reactome:R-HSA-111465|reactome:R-HSA-75153|reactome:R-HSA-8980692|reactome:R-HSA-983170|ensembl:ENSG00000185825(gene)|ensembl:ENST00000345046(transcript)|ensembl:ENST00000647529(transcript)|ensembl:ENST00000672675(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001243376.1|refseq:NP_001132929.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:m0aN00PLZJDWA/K1vEbla1W9+S89606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:au3msD2uP8pbQM0GXAoRWCoTHtE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9HC07	uniprotkb:O43490	intact:EBI-3920600|uniprotkb:B4DHW1|ensembl:ENSP00000370736|uniprotkb:Q9BTN9|uniprotkb:A8K3P8|uniprotkb:Q9NZ34	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:tm165_human(display_long)|uniprotkb:TMEM165(gene name)|psi-mi:TMEM165(display_short)|uniprotkb:TPARL(gene name synonym)|uniprotkb:Transmembrane protein PT27(gene name synonym)|uniprotkb:Transmembrane protein TPARL(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451688|imex:IM-27077-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134851(gene)|ensembl:ENST00000381334(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032468"(Golgi calcium ion homeostasis)|go:"GO:0032472"(Golgi calcium ion transport)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071421"(manganese ion transmembrane transport)|interpro:IPR001727(Protein of unknown function UPF0016)|mint:Q9HC07|refseq:NP_060945.2|refseq:XP_016863901.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:ldHk1rPCEZrMLw8Pj6zVshPaNw09606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:OTvjhowtNpRoTut+eBFtemtdmXU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BQI0	uniprotkb:O43490	intact:EBI-358576|uniprotkb:Q6ZR40|uniprotkb:Q8NAX7|uniprotkb:Q8WU47|uniprotkb:Q9H9G0|uniprotkb:B2RBC4|ensembl:ENSP00000247291	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:aif1l_human(display_long)|uniprotkb:UNQ672/PRO1306(orf name)|uniprotkb:AIF1L(gene name)|psi-mi:AIF1L(display_short)|uniprotkb:C9orf58(gene name synonym)|uniprotkb:IBA2(gene name synonym)|uniprotkb:Ionized calcium-binding adapter molecule 2(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451692|imex:IM-27077-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001172024.1|refseq:NP_001172025.1|refseq:NP_113614.1|ensembl:ENSG00000126878(gene)|ensembl:ENST00000247291(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097178"(ruffle assembly)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR028453|interpro:IPR042433|rcsb pdb:2JJZ|rcsb pdb:2VTG	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:/FPBcx3gPhY4kmNrngZfmmN2D0A9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:hJSf3oOv58U6vsnFqIiEEoCE3FM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BQB6	uniprotkb:O43490	intact:EBI-6256462|ensembl:ENSP00000378426|uniprotkb:A6NIQ6|uniprotkb:B2R4Z6|uniprotkb:Q6UX90|uniprotkb:Q7Z2R4	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:vkor1_human(display_long)|uniprotkb:VKORC1(gene name)|psi-mi:VKORC1(display_short)|uniprotkb:VKOR(gene name synonym)|uniprotkb:Vitamin K1 2,3-epoxide reductase subunit 1(gene name synonym)|uniprotkb:MSTP134(orf name)|uniprotkb:MSTP576(orf name)|uniprotkb:UNQ308/PRO351(orf name)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451696|imex:IM-27077-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000167397(gene)|ensembl:ENST00000394975(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017144"|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0060348"(bone development)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q9BQB6|rcsb pdb:6WV3|rcsb pdb:6WV4|rcsb pdb:6WV5|rcsb pdb:6WV6|rcsb pdb:6WV7|rcsb pdb:6WVH|reactome:R-HSA-6806664|refseq:NP_001298240.1|refseq:NP_076869.1|refseq:NP_996560.1	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:C3RrQ+y7Huai7PExa9LOvfqni+U9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:XBdWoxBzRUXBKxeHrxaCa41vk54	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13164	uniprotkb:O43490	intact:EBI-348505|uniprotkb:Q15322|ensembl:ENSP00000330825|ensembl:ENSP00000386187|ensembl:ENSP00000437057|ensembl:ENSP00000505380|uniprotkb:Q53XZ0	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ifm1_human(display_long)|uniprotkb:IFITM1(gene name)|psi-mi:IFITM1(display_short)|uniprotkb:IFI17(gene name synonym)|uniprotkb:Interferon-inducible protein 9-27(gene name synonym)|uniprotkb:Interferon-induced protein 17(gene name synonym)|uniprotkb:Leu-13 antigen(gene name synonym)|uniprotkb:CD225(gene name synonym)|uniprotkb:Dispanin subfamily A member 2a(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451700|imex:IM-27077-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003632.3|ensembl:ENSG00000185885(gene)|ensembl:ENST00000328221(transcript)|ensembl:ENST00000408968(transcript)|ensembl:ENST00000528780(transcript)|ensembl:ENST00000680588(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007593(Interferon-induced transmembrane protein)|mint:P13164|reactome:R-HSA-198933|reactome:R-HSA-909733|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|dip:DIP-32672N	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:+WojFAUu4AZAydvg1PBePvxrBWs9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:Zjfzv/ifEed0oeb+iLb8fLed+Qs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01628	uniprotkb:O43490	intact:EBI-7932862|uniprotkb:Q96HK8|uniprotkb:Q53Y76|uniprotkb:Q96J15|intact:MINT-2805186|ensembl:ENSP00000382707	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ifm3_human(display_long)|uniprotkb:IFITM3(gene name)|psi-mi:IFITM3(display_short)|uniprotkb:Dispanin subfamily A member 2b(gene name synonym)|uniprotkb:Interferon-inducible protein 1-8U(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451704|imex:IM-27077-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066362.2|ensembl:ENSG00000142089(gene)|ensembl:ENST00000399808(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007593(Interferon-induced transmembrane protein)|mint:Q01628|reactome:R-HSA-909733|go:"GO:0009615"(response to virus)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	comment:mint	-	figure legend:Supplementary Table 2 -13|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:jR3B3HZZPwQAA1ccX0QeKYqa2449606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:wCgqnDAVVlBWZmWz70BkRoQky1E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9P0B6	uniprotkb:O43490	intact:EBI-9083477|uniprotkb:Q5T7F7|uniprotkb:Q9BTQ9|ensembl:ENSP00000362507	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:cc167_human(display_long)|uniprotkb:CCDC167(gene name)|psi-mi:CCDC167(display_short)|uniprotkb:C6orf129(gene name synonym)|uniprotkb:HSPC265(orf name)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451708|imex:IM-27077-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612502.1|ensembl:ENSG00000198937(gene)|ensembl:ENST00000373408(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR028194	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:el6K1I4AQwH3OgjfL0EgIJmQjVc9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:DnwLVS/EyYsnT+COin5YQ8HzOBs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H3K2	uniprotkb:O43490	intact:EBI-2868909|uniprotkb:A8K9Z9|uniprotkb:Q5VT95|uniprotkb:O95894|uniprotkb:Q9H0P2|uniprotkb:D3DWE0|ensembl:ENSP00000361207	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:ghitm_human(display_long)|uniprotkb:GHITM(gene name)|psi-mi:GHITM(display_short)|uniprotkb:DERP2(gene name synonym)|uniprotkb:MICS1(gene name synonym)|uniprotkb:TMBIM5(gene name synonym)|uniprotkb:Dermal papilla-derived protein 2(gene name synonym)|uniprotkb:Mitochondrial morphology and cristae structure 1(gene name synonym)|uniprotkb:Transmembrane BAX inhibitor motif-containing protein 5(gene name synonym)|uniprotkb:My021(orf name)|uniprotkb:UNQ244/PRO281(orf name)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451712|imex:IM-27077-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055209.2|ensembl:ENSG00000165678(gene)|ensembl:ENST00000372134(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR006214(Protein of unknown function UPF0005)|interpro:IPR035871|mint:Q9H3K2	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:HlNwyLRPIHhjs1bYJQE+IqZ00qc9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:ML57eT3YKYfHe6u1YazDmAGXFmI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y6A9	uniprotkb:O43490	intact:EBI-8852196|uniprotkb:B3KNF8|uniprotkb:Q9BVW1|ensembl:ENSP00000233025|uniprotkb:X6R2S6	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:spcs1_human(display_long)|uniprotkb:SPCS1(gene name)|psi-mi:SPCS1(display_short)|uniprotkb:SPC12(gene name synonym)|uniprotkb:Microsomal signal peptidase 12 kDa subunit(gene name synonym)|uniprotkb:HSPC033(orf name)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451716|imex:IM-27077-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054760.3|ensembl:ENSG00000114902(gene)|ensembl:ENST00000233025(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0019068"(virion assembly)|go:"GO:0019082"(viral protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009542(Microsomal signal peptidase 12 kDa subunit)|interpro:IPR037713|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/10/18	rogid:X9U6jCa1mT05K+3QABDJZAMKr/I9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:5gu61R/fOMqI9LJJgmpW2PdM0XI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95715	uniprotkb:O43490	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451720|imex:IM-27077-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -17|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:YcTaMG1oEaNA+CAHBAhzVKsv+84	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48201	uniprotkb:O43490	intact:EBI-347797|uniprotkb:Q4ZFX7|uniprotkb:B2R4Z0|uniprotkb:D3DPF0|ensembl:ENSP00000284727|ensembl:ENSP00000376324|ensembl:ENSP00000387317	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:at5g3_human(display_long)|uniprotkb:ATP5MC3(gene name)|psi-mi:ATP5MC3(display_short)|uniprotkb:ATP synthase lipid-binding protein(gene name synonym)|uniprotkb:ATP synthase membrane subunit c locus 3(gene name synonym)|uniprotkb:ATP synthase proteolipid P3(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit C3"(gene name synonym)|uniprotkb:ATP5G3(gene name synonym)|uniprotkb:ATPase protein 9(gene name synonym)|uniprotkb:ATPase subunit c(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451724|imex:IM-27077-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002258.1|refseq:NP_001680.1|ensembl:ENSG00000154518(gene)|ensembl:ENST00000284727(transcript)|ensembl:ENST00000392541(transcript)|ensembl:ENST00000409194(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|interpro:IPR000454(ATPase, F0 complex, subunit C)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR020537|interpro:IPR035921|interpro:IPR038662|reactome:R-HSA-163210|reactome:R-HSA-8949613	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -18|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:09JFHVdOi1FEXzpqyLx0aDVhvTk9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:wJXxBBBVIGM5UFlT/zaNvbLKGp8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NYP7	uniprotkb:O43490	intact:EBI-11037623|uniprotkb:Q5TGH5|uniprotkb:F6SH78|uniprotkb:B4DZJ2|uniprotkb:Q59EL3|uniprotkb:Q8NCG4|uniprotkb:Q7L2S5|uniprotkb:Q9UI22|uniprotkb:Q6NXE7|ensembl:ENSP00000306640	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:elov5_human(display_long)|uniprotkb:Very long chain 3-ketoacyl-CoA synthase 5(gene name synonym)|uniprotkb:Very long chain 3-oxoacyl-CoA synthase 5(gene name synonym)|uniprotkb:PRO0530(orf name)|uniprotkb:ELOVL5(gene name)|psi-mi:ELOVL5(display_short)|uniprotkb:3-keto acyl-CoA synthase ELOVL5(gene name synonym)|uniprotkb:ELOVL fatty acid elongase 5(gene name synonym)|uniprotkb:ELOVL2(gene name synonym)|uniprotkb:Fatty acid elongase 1(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451728|imex:IM-27077-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229757.1|refseq:NP_001229759.1|refseq:NP_001229760.1|refseq:NP_001288785.1|refseq:NP_068586.1|ensembl:ENSG00000012660(gene)|ensembl:ENST00000304434(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006636"(unsaturated fatty acid biosynthetic process)|go:"GO:0009922"(fatty acid elongase activity)|go:"GO:0016020"(membrane)|go:"GO:0019367"(fatty acid elongation, saturated fatty acid)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034625"(fatty acid elongation, monounsaturated fatty acid)|go:"GO:0034626"(fatty acid elongation, polyunsaturated fatty acid)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0097447"(dendritic tree)|go:"GO:0102336"(3-oxo-arachidoyl-CoA synthase activity)|go:"GO:0102337"(3-oxo-cerotoyl-CoA synthase activity)|go:"GO:0102338"(3-oxo-lignoceronyl-CoA synthase activity)|go:"GO:0102756"(very-long-chain 3-ketoacyl-CoA synthase activity)|interpro:IPR002076(GNS1/SUR4 membrane protein)|interpro:IPR033677|reactome:R-HSA-2046105|reactome:R-HSA-2046106|reactome:R-HSA-75876	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -19|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:7kQZS7mYa5eCSOslo4+z9nwtxxk9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:SuIlRfqe9onQOc2NX3/YNNnH6y0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95490-2	uniprotkb:O43490	intact:EBI-21451996|ensembl:ENSP00000322270|ensembl:ENSP00000353006|ensembl:ENSP00000501431	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	psi-mi:o95490-2(display_long)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 2(gene name synonym)|uniprotkb:Latrophilin homolog 1(gene name synonym)|uniprotkb:Latrophilin-2(gene name synonym)|uniprotkb:Lectomedin-1(gene name synonym)|uniprotkb:Lectomedin-1 gamma(isoform synonym)|uniprotkb:ADGRL2(gene name)|psi-mi:ADGRL2(display_short)|uniprotkb:KIAA0786(gene name synonym)|uniprotkb:LEC1(gene name synonym)|uniprotkb:LPHH1(gene name synonym)|uniprotkb:LPHN2(gene name synonym)	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451736|imex:IM-27077-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2865302(isoform-parent)|ensembl:ENSG00000117114(gene)|ensembl:ENST00000319517(transcript)|ensembl:ENST00000359929(transcript)|ensembl:ENST00000674393(transcript)|uniprotkb:O95490-2(isoform-parent)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	-	-	-	figure legend:Supplementary Table 2 -20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:yFwZhLSTY27PuKfkTy16uMxBdlA9606	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rigid:gvxd4RI5nQzG/GEf+jCKzgusY/o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43490	uniprotkb:Q04941	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-608347|ensembl:ENSP00000365505|uniprotkb:A6NDT7|uniprotkb:Q32MM8	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:plp2_human(display_long)|uniprotkb:Intestinal membrane A4 protein(gene name synonym)|uniprotkb:Differentiation-dependent protein A4(gene name synonym)|uniprotkb:PLP2(gene name)|psi-mi:PLP2(display_short)|uniprotkb:A4(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451740|imex:IM-27077-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	ensembl:ENSG00000102007(gene)|ensembl:ENST00000376327(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|refseq:NP_002659.1	-	-	-	figure legend:Supplementary Table 2 -21|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:mQOlRVDVw9W4XWAzftif1tnKEdU9606	rigid:YS69gFhVUGYt/JnEXjLh/Cv2rD8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43490	uniprotkb:Q8N6L1-2	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-10699047	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:q8n6l1-2(display_long)|uniprotkb:KRTCAP2(gene name)|psi-mi:KRTCAP2(display_short)|uniprotkb:KCP2(gene name synonym)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451744|imex:IM-27077-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	intact:EBI-1053775(isoform-parent)	-	-	isoform-comment:Produced at low levels due to suboptimal Kozak context.	figure legend:Supplementary Table 2 -22|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:+ZvuqXNBQYqonkgCD5s8Vi5ZJ5I9606	rigid:CPw9DgrKGPbOFAR0Ye8dspH1EJA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43490	uniprotkb:Q9BUF7-2	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-17233035|ensembl:ENSP00000349204	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:q9buf7-2(display_long)|uniprotkb:CRB3(gene name)|psi-mi:CRB3(display_short)|uniprotkb:UNQ588/PRO1158(orf name)|uniprotkb:B(isoform synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451748|imex:IM-27077-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	intact:EBI-9844372(isoform-parent)|ensembl:ENSG00000130545(gene)|ensembl:ENST00000356762(transcript)	-	-	-	figure legend:Supplementary Table 2 -23|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:9uE3tHwZYHpn8wvEy1rPvLclkoY9606	rigid:QcdT2Uvfp1/QZtse/p1tHPmYEL8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43490	uniprotkb:Q9Y287	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451752|imex:IM-27077-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225	-	-	-	figure legend:Supplementary Table 2 -24|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606	rigid:yYl3xLksr/yybXmdcVsGBERbZHw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43490	uniprotkb:O75503	intact:EBI-3447549|uniprotkb:Q6SV51|uniprotkb:Q6SV49|uniprotkb:Q6SV53|uniprotkb:Q6SV52|uniprotkb:Q96EN6|uniprotkb:Q6SV50|ensembl:ENSP00000415481|ensembl:ENSP00000426809	intact:EBI-1043514|ensembl:ENSP00000366673|ensembl:ENSP00000490181|uniprotkb:B3KQK7	psi-mi:prom1_human(display_long)|uniprotkb:PROM1(gene name)|psi-mi:PROM1(display_short)|uniprotkb:PROML1(gene name synonym)|uniprotkb:Antigen AC133(gene name synonym)|uniprotkb:Prominin-like protein 1(gene name synonym)|uniprotkb:MSTP061(orf name)	psi-mi:cln5_human(display_long)|uniprotkb:CLN5(gene name)|psi-mi:CLN5(display_short)	psi-mi:"MI:0112"(ubiquitin reconstruction)	Mak et al. (2012)	pubmed:23084749|imex:IM-27077	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21451756|imex:IM-27077-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011512192.1|refseq:XP_011512194.1|refseq:XP_011512195.1|refseq:XP_011512196.1|refseq:XP_011512197.1|refseq:XP_011512198.1|refseq:XP_011512199.1|refseq:XP_011512202.1|refseq:XP_011512204.1|refseq:NP_001139319.1|refseq:NP_001139320.1|refseq:NP_001139321.1|refseq:NP_001139322.1|refseq:NP_001139323.1|refseq:NP_001139324.1|refseq:NP_006008.1|refseq:XP_011512201.2|go:"GO:0005929"(cilium)|go:"GO:0009986"(cell surface)|go:"GO:0010842"(retina layer formation)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042805"(actinin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071914"(prominosome)|go:"GO:0072112"(glomerular visceral epithelial cell differentiation)|go:"GO:0072139"(glomerular parietal epithelial cell differentiation)|go:"GO:2000768"(positive regulation of nephron tubule epithelial cell differentiation)|interpro:IPR008795(Prominin)|ensembl:ENSG00000007062(gene)|ensembl:ENST00000447510(transcript)|ensembl:ENST00000510224(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|refseq:XP_005248252.1|refseq:XP_005248253.1|refseq:XP_016864291.1|refseq:XP_016864292.1|refseq:XP_016864293.1|refseq:XP_016864294.1|refseq:XP_016864288.1	ensembl:ENSG00000102805(gene)|ensembl:ENST00000377453(transcript)|ensembl:ENST00000636183(transcript)|go:"GO:0005537"(mannose binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006465"(signal peptide processing)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007420"(brain development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042551"(neuron maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070085"(glycosylation)|go:"GO:1904426"(positive regulation of GTP binding)|interpro:IPR026138|go:"GO:0022008"(neurogenesis)|refseq:NP_006484.1	-	-	-	figure legend:Supplementary Table 2 -25|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2019/05/08	2019/07/22	rogid:xSb4ppzpYRN1osJZgkqM3Ugijas9606	rogid:YBJqxznEkJjC7Rdm95cpHHBPuE49606	rigid:nTh1EHR4OUg0FO+v/8PNUDTivT4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)